[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.] [@gregmushen](/creator/twitter/gregmushen) "@_C0nsciousness_ @GregNotSure @CigsMake Yes. Just add the gene via CRISPR (not possible) then send them up Everest with a simulated load. Should be super easy"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948129687882109019) 2025-07-23 21:14:46 UTC 24.1K followers, XX engagements "@Tuluminati888 Love that. Ill see you in Wonderland 🫡"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949197219732595141) 2025-07-26 19:56:46 UTC 24.1K followers, XX engagements "What happens to gut health on Keto/Carnivore Can you still have a health gut"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948925808879477114) 2025-07-26 01:58:16 UTC 24.1K followers, 13.4K engagements "Branched SCFA (BCFA) BCFA is a marker of protein fermentation. While it is similar chemically to SCFA but a weak agonist of FFAR2 The problem is BCFA arent a harmless byproduct. They are associated with ammonia p-cresol and biogenic amines. They are potentially cytotoxic and pro inflammatory to colonocytes"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948925855239209207) 2025-07-26 01:58:27 UTC 24.1K followers, 1075 engagements "@DrRyanPDaly Oh nice. I will have to look into this. Have been researching different fibers and believe Ive figured out how to synthesize RS5 in my kitchen"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949170382855983341) 2025-07-26 18:10:07 UTC 24.1K followers, XX engagements "A studio portrait evoking timeless emotional depth and quiet intensity shot on a Mamiya RZ67 Pro II with a Mamiya-Sekor 110mm f/2.8 lens using Kodak Tri-X XXX film pushed to XXX ISO. The subject is framed in a medium close-up with generous negative space focus razor-sharp on the eyes with soft falloff. Lighting is from a large Profoto Octabank to camera-left at a XX angle slightly above eye level creating wraparound highlights and soft shadows. Minimal fill is used with a narrow strip softbox and grid behind the subject to the right for subtle rim lighting. Background is seamless matte gray"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1945713080928960850) 2025-07-17 05:12:02 UTC 24.1K followers, XXX engagements "Yes. In short in order to have the healthiest microbiome you need the proper colonic pH which is all but impossible to achieve on carnivore. Fiber particularly fermentable fiber which produce SCFA like butyrate which will bring this pH down to a range where we can have a diverse and healthy microbiome. But fiber also does so much more I included around five specific microbiome related studies in the thread. There are reams of studies on fiber itself. And theres this study which just says it plainly"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948027760192192694) 2025-07-23 14:29:45 UTC 24.1K followers, XX engagements "Summary - Butyrate drops XX percent - Colonocytes starve and trigger autophagy - BHB is not butyrate - Colon pH rises favoring proteolytic bacteria - Branched chain SCFA ammonia and ImP increase - Mucin fermentation cannot keep up - Zonulin rises the barrier breaks"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948925858095530337) 2025-07-26 01:58:28 UTC 24.1K followers, XXX engagements "Whos one person living or dead youd like to see on X Ill go first"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947302216068632804) 2025-07-21 14:26:42 UTC 24.1K followers, 3836 engagements "Apparently you have not heard of a hyperinsulinemic euglycemic clamp. The discussion here is centered on the observed transient changes in insulin sensitivity during different phases of a womans cycle. These are short term changes that are not pathological. You are missing this point"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948411918076838225) 2025-07-24 15:56:15 UTC 24.1K followers, XX engagements "Great study. What they found was: - A healthy plant based diet (whole grains fruits vegetables legumes nuts) was associated with 25-29% reduced risk of IBD and a XX% lower risk of surgery - An unhealthy plant based diet (refined carbs sweets sugary beverages) was associated with a 48-54% increased risk of IBD and a XXX% increased risk of surgery - CRP and INFLA score explained between 3.9-22% of PDI and IBD suggesting other factors like microbiome were in play - They said it likely acted through SCFA production from the fiber - they referenced Bolte 2021 included below - This is exactly what"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948018624301830288) 2025-07-23 13:53:27 UTC 24.1K followers, XX engagements "I referenced about five studies so let me know which one and I can do a more detailed breakdown. But to summarize them altogether - we know which taxa we need - we know what pH we roughly need to have those - carnivore since it lacks fiber will be at a much higher pH - higher pH will mean more proteolytic taxa - fiber is needed to bring ph down"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948012854956917234) 2025-07-23 13:30:31 UTC 24.1K followers, XX engagements "@BowTiedGatorDDS Seems to be the case. At any rate Im going to develop an animal based fiber supplement for the carnivore community. As one does. Lets burn this down"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947876830989717967) 2025-07-23 04:30:00 UTC 24.1K followers, XXX engagements "@meta_boli Definitely with the IGF-1. I think what may be happening is some selection bias. Unless you know how to cook it tofu isnt the best tasting thing. Plenty of vegan bodybuilders who are absolutely jacked and have tofu as the staple"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947710606813106268) 2025-07-22 17:29:30 UTC 24.1K followers, XXX engagements "Common misconception. Gluconeogensis is demand driven not supply driven"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948178631442022507) 2025-07-24 00:29:15 UTC 24.1K followers, 14.3K engagements "This is XXX% true* *if you invert every claim"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947912706406944931) 2025-07-23 06:52:34 UTC 24.1K followers, 1648 engagements "How To Construct a Fiber Heavy Tsimane Diet To get 70g of fiber and 55g of resistant starch this is what a day of eating would look like: - 350g green plantain (boiled and cooled) - 400g red potato (cooked and cooled) - 300g jasmine rice (cooked and cooled) - 250g pinto beans (pressure cooked) - 150g of blueberries - 200g of mixed vegetables - 30g of raw mixed nuts - 390g of chicken - X tbsp of olive oil Macros Calories: 2665 Protein: 161g Carbohydrate: 347g Fat: 43g Fiber: 70g Resistant starch: 55g This would be a propionate rich SCFA profile like the Tsimane"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949273155513839714) 2025-07-27 00:58:30 UTC 24.1K followers, 3001 engagements "I could say the sky is blue. And a gaggle of carnivores* would come in to correct me. * defined as those who form their identity around the diet not those who can have rational conversations and engage in nuance. Not talking about them"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948421838637605231) 2025-07-24 16:35:40 UTC 24.1K followers, 1943 engagements "@DrCamRx @DrCamMaximus Hunter Biden a crackhead who realized the places you buy crack are too dangerous so he started making his own"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948059167081857469) 2025-07-23 16:34:33 UTC 24.1K followers, XXX engagements "The more I look into the microbiome and what it responds to the more it makes me think that most of the plants we evolved to eat are lost. The fibers are microbiome responds to well appear to be somewhat rare. Green bananas chicory root plantains guar gum acacia inulin from tubers beta glucan from oats. These resemble wild like plants bark roots unripe starches cooked starches that were roasted on a fire to be edible and then later cooled rhizomes (tumeric ginger galangal etc.) etc. Could explain both why some people dont do well on fiber and also why just adding more fiber without the"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949191439604490269) 2025-07-26 19:33:48 UTC 24.1K followers, 13K engagements "Can you still get all your nutrients from food A common belief is that our food supply is too depleted and that hitting all your micros from food alone is nearly impossible. That can be true if youre not tracking micros and not being intentional with your food selection. But if you do track and build your meals around nutrient density its absolutely possible. Personally Ive been tracking my micronutrients and consistently hitting all targets from food alone except for vitamin D (VDR polymorphism and low light Seattle) and B vitamins (MTRR polymorphism). My go to for magnesium is a daily"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1931769809395761358) 2025-06-08 17:46:27 UTC 24.1K followers, 31.6K engagements "A FFAR2 agonist peptide would be 🔥 FFAR2 inhibits adipocyte lipolysis increases PYY and GLP-1 endogenously would help restore gut barrier function could reduce visceral adipose inflammation and modulate immune function. Or you could just eat more fiber"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948561929339105424) 2025-07-25 01:52:21 UTC 24.1K followers, 2133 engagements "Yes. Although with some important distinctions. Also I absolutely share your frustration with microbiome research. Butyrate production is extremely important in the colon for many reasons but one of the top reasons is it supplies XX% of ATP to the colonocytes. Butyrate is mainly produced by saccharolytic bacteria in the colon. They ferment fiber to butyrate acetate and propionate. SCFA is acidic so the production or lack thereof is the primary driver of colonic pH. pH is the driver of what genera live and which ones dominate. In higher pH proteolytic genera are favored and in the instance of"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949131922548093175) 2025-07-26 15:37:18 UTC 24.1K followers, XXX engagements "@creatine_cycle Even worse. One shotted by product (CPO). Leave it to product to always mess things up"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1945918143987339598) 2025-07-17 18:46:53 UTC 24.1K followers, 1992 engagements "There isnt a single thing you could eat that does more than fiber. And ironically its the one thing you dont technically need to survive"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947683263084171717) 2025-07-22 15:40:50 UTC 24.1K followers, 43.9K engagements "My toxic trait is if I find a rabbit hole I cant help but jump down it"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1949146799220166861) 2025-07-26 16:36:24 UTC 24.1K followers, 2689 engagements "@Ancestral_Coach Yes. I see people say this all the time. That it just converts to glucose"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948359137001447782) 2025-07-24 12:26:31 UTC 24.1K followers, XX engagements "We werent meant to snack all day. Oh really Hadza men graze constantly while hunting. Berries baobab honey whatever they find. By the time theyre back theyve eaten XX% of their calories. And they have some of the best metabolic health on Earth. They also move a lot"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947421029678387649) 2025-07-21 22:18:49 UTC 24.1K followers, 30.9K engagements "I think what may be difficult to determine is a single cause. It could be a combination of factors that make it difficult to fuse table or associated a single cause. I think the root cause is caloric flux but then describing in broad trends whats caused that is likely multifactorial. - Decreased exercise - Increase reliance on processed food - More processed food means less fermentable fiber - Less fermentable fiber means less SCFA - Less SCFA means less FFAR2 signaling which then means less endogenous GLP-1/PYY increased insulin resistance less hormonal satiation increased adiposity -"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1948865264965353803) 2025-07-25 21:57:41 UTC 24.1K followers, XX engagements "@nntaleb Couldnt agree more. Theres also a risk of upregulation of glycolic reliance"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947411965124755478) 2025-07-21 21:42:48 UTC 24.1K followers, 7587 engagements "Circadian rhythm governs the SCN or master clock. Incredibly important. But its not the only clock we have. We have other peripheral clocks. SCN signals these peripheral clocks but they also respond to independent stimuli such as food. 👇"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1947804334588367114) 2025-07-22 23:41:56 UTC 24.1K followers, 9742 engagements "At the highest dose something shifted. Not just labs but me. Suddenly I was listening to country music and had this strong urge to buy a vintage truck. And for some reason I started popping Zyns"  [@gregmushen](/creator/x/gregmushen) on [X](/post/tweet/1911592490924474730) 2025-04-14 01:29:00 UTC 24.1K followers, 69.2K engagements
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
@gregmushen
"@C0nsciousness @GregNotSure @CigsMake Yes. Just add the gene via CRISPR (not possible) then send them up Everest with a simulated load. Should be super easy"
@gregmushen on X 2025-07-23 21:14:46 UTC 24.1K followers, XX engagements
"@Tuluminati888 Love that. Ill see you in Wonderland 🫡" @gregmushen on X 2025-07-26 19:56:46 UTC 24.1K followers, XX engagements
"What happens to gut health on Keto/Carnivore Can you still have a health gut" @gregmushen on X 2025-07-26 01:58:16 UTC 24.1K followers, 13.4K engagements
"Branched SCFA (BCFA) BCFA is a marker of protein fermentation. While it is similar chemically to SCFA but a weak agonist of FFAR2 The problem is BCFA arent a harmless byproduct. They are associated with ammonia p-cresol and biogenic amines. They are potentially cytotoxic and pro inflammatory to colonocytes" @gregmushen on X 2025-07-26 01:58:27 UTC 24.1K followers, 1075 engagements
"@DrRyanPDaly Oh nice. I will have to look into this. Have been researching different fibers and believe Ive figured out how to synthesize RS5 in my kitchen" @gregmushen on X 2025-07-26 18:10:07 UTC 24.1K followers, XX engagements
"A studio portrait evoking timeless emotional depth and quiet intensity shot on a Mamiya RZ67 Pro II with a Mamiya-Sekor 110mm f/2.8 lens using Kodak Tri-X XXX film pushed to XXX ISO. The subject is framed in a medium close-up with generous negative space focus razor-sharp on the eyes with soft falloff. Lighting is from a large Profoto Octabank to camera-left at a XX angle slightly above eye level creating wraparound highlights and soft shadows. Minimal fill is used with a narrow strip softbox and grid behind the subject to the right for subtle rim lighting. Background is seamless matte gray" @gregmushen on X 2025-07-17 05:12:02 UTC 24.1K followers, XXX engagements
"Yes. In short in order to have the healthiest microbiome you need the proper colonic pH which is all but impossible to achieve on carnivore. Fiber particularly fermentable fiber which produce SCFA like butyrate which will bring this pH down to a range where we can have a diverse and healthy microbiome. But fiber also does so much more I included around five specific microbiome related studies in the thread. There are reams of studies on fiber itself. And theres this study which just says it plainly" @gregmushen on X 2025-07-23 14:29:45 UTC 24.1K followers, XX engagements
"Summary - Butyrate drops XX percent - Colonocytes starve and trigger autophagy - BHB is not butyrate - Colon pH rises favoring proteolytic bacteria - Branched chain SCFA ammonia and ImP increase - Mucin fermentation cannot keep up - Zonulin rises the barrier breaks" @gregmushen on X 2025-07-26 01:58:28 UTC 24.1K followers, XXX engagements
"Whos one person living or dead youd like to see on X Ill go first" @gregmushen on X 2025-07-21 14:26:42 UTC 24.1K followers, 3836 engagements
"Apparently you have not heard of a hyperinsulinemic euglycemic clamp. The discussion here is centered on the observed transient changes in insulin sensitivity during different phases of a womans cycle. These are short term changes that are not pathological. You are missing this point" @gregmushen on X 2025-07-24 15:56:15 UTC 24.1K followers, XX engagements
"Great study. What they found was: - A healthy plant based diet (whole grains fruits vegetables legumes nuts) was associated with 25-29% reduced risk of IBD and a XX% lower risk of surgery - An unhealthy plant based diet (refined carbs sweets sugary beverages) was associated with a 48-54% increased risk of IBD and a XXX% increased risk of surgery - CRP and INFLA score explained between 3.9-22% of PDI and IBD suggesting other factors like microbiome were in play - They said it likely acted through SCFA production from the fiber - they referenced Bolte 2021 included below - This is exactly what" @gregmushen on X 2025-07-23 13:53:27 UTC 24.1K followers, XX engagements
"I referenced about five studies so let me know which one and I can do a more detailed breakdown. But to summarize them altogether - we know which taxa we need - we know what pH we roughly need to have those - carnivore since it lacks fiber will be at a much higher pH - higher pH will mean more proteolytic taxa - fiber is needed to bring ph down" @gregmushen on X 2025-07-23 13:30:31 UTC 24.1K followers, XX engagements
"@BowTiedGatorDDS Seems to be the case. At any rate Im going to develop an animal based fiber supplement for the carnivore community. As one does. Lets burn this down" @gregmushen on X 2025-07-23 04:30:00 UTC 24.1K followers, XXX engagements
"@meta_boli Definitely with the IGF-1. I think what may be happening is some selection bias. Unless you know how to cook it tofu isnt the best tasting thing. Plenty of vegan bodybuilders who are absolutely jacked and have tofu as the staple" @gregmushen on X 2025-07-22 17:29:30 UTC 24.1K followers, XXX engagements
"Common misconception. Gluconeogensis is demand driven not supply driven" @gregmushen on X 2025-07-24 00:29:15 UTC 24.1K followers, 14.3K engagements
"This is XXX% true* *if you invert every claim" @gregmushen on X 2025-07-23 06:52:34 UTC 24.1K followers, 1648 engagements
"How To Construct a Fiber Heavy Tsimane Diet To get 70g of fiber and 55g of resistant starch this is what a day of eating would look like: - 350g green plantain (boiled and cooled) - 400g red potato (cooked and cooled) - 300g jasmine rice (cooked and cooled) - 250g pinto beans (pressure cooked) - 150g of blueberries - 200g of mixed vegetables - 30g of raw mixed nuts - 390g of chicken - X tbsp of olive oil Macros Calories: 2665 Protein: 161g Carbohydrate: 347g Fat: 43g Fiber: 70g Resistant starch: 55g This would be a propionate rich SCFA profile like the Tsimane" @gregmushen on X 2025-07-27 00:58:30 UTC 24.1K followers, 3001 engagements
"I could say the sky is blue. And a gaggle of carnivores* would come in to correct me. * defined as those who form their identity around the diet not those who can have rational conversations and engage in nuance. Not talking about them" @gregmushen on X 2025-07-24 16:35:40 UTC 24.1K followers, 1943 engagements
"@DrCamRx @DrCamMaximus Hunter Biden a crackhead who realized the places you buy crack are too dangerous so he started making his own" @gregmushen on X 2025-07-23 16:34:33 UTC 24.1K followers, XXX engagements
"The more I look into the microbiome and what it responds to the more it makes me think that most of the plants we evolved to eat are lost. The fibers are microbiome responds to well appear to be somewhat rare. Green bananas chicory root plantains guar gum acacia inulin from tubers beta glucan from oats. These resemble wild like plants bark roots unripe starches cooked starches that were roasted on a fire to be edible and then later cooled rhizomes (tumeric ginger galangal etc.) etc. Could explain both why some people dont do well on fiber and also why just adding more fiber without the" @gregmushen on X 2025-07-26 19:33:48 UTC 24.1K followers, 13K engagements
"Can you still get all your nutrients from food A common belief is that our food supply is too depleted and that hitting all your micros from food alone is nearly impossible. That can be true if youre not tracking micros and not being intentional with your food selection. But if you do track and build your meals around nutrient density its absolutely possible. Personally Ive been tracking my micronutrients and consistently hitting all targets from food alone except for vitamin D (VDR polymorphism and low light Seattle) and B vitamins (MTRR polymorphism). My go to for magnesium is a daily" @gregmushen on X 2025-06-08 17:46:27 UTC 24.1K followers, 31.6K engagements
"A FFAR2 agonist peptide would be 🔥 FFAR2 inhibits adipocyte lipolysis increases PYY and GLP-1 endogenously would help restore gut barrier function could reduce visceral adipose inflammation and modulate immune function. Or you could just eat more fiber" @gregmushen on X 2025-07-25 01:52:21 UTC 24.1K followers, 2133 engagements
"Yes. Although with some important distinctions. Also I absolutely share your frustration with microbiome research. Butyrate production is extremely important in the colon for many reasons but one of the top reasons is it supplies XX% of ATP to the colonocytes. Butyrate is mainly produced by saccharolytic bacteria in the colon. They ferment fiber to butyrate acetate and propionate. SCFA is acidic so the production or lack thereof is the primary driver of colonic pH. pH is the driver of what genera live and which ones dominate. In higher pH proteolytic genera are favored and in the instance of" @gregmushen on X 2025-07-26 15:37:18 UTC 24.1K followers, XXX engagements
"@creatine_cycle Even worse. One shotted by product (CPO). Leave it to product to always mess things up" @gregmushen on X 2025-07-17 18:46:53 UTC 24.1K followers, 1992 engagements
"There isnt a single thing you could eat that does more than fiber. And ironically its the one thing you dont technically need to survive" @gregmushen on X 2025-07-22 15:40:50 UTC 24.1K followers, 43.9K engagements
"My toxic trait is if I find a rabbit hole I cant help but jump down it" @gregmushen on X 2025-07-26 16:36:24 UTC 24.1K followers, 2689 engagements
"@Ancestral_Coach Yes. I see people say this all the time. That it just converts to glucose" @gregmushen on X 2025-07-24 12:26:31 UTC 24.1K followers, XX engagements
"We werent meant to snack all day. Oh really Hadza men graze constantly while hunting. Berries baobab honey whatever they find. By the time theyre back theyve eaten XX% of their calories. And they have some of the best metabolic health on Earth. They also move a lot" @gregmushen on X 2025-07-21 22:18:49 UTC 24.1K followers, 30.9K engagements
"I think what may be difficult to determine is a single cause. It could be a combination of factors that make it difficult to fuse table or associated a single cause. I think the root cause is caloric flux but then describing in broad trends whats caused that is likely multifactorial. - Decreased exercise - Increase reliance on processed food - More processed food means less fermentable fiber - Less fermentable fiber means less SCFA - Less SCFA means less FFAR2 signaling which then means less endogenous GLP-1/PYY increased insulin resistance less hormonal satiation increased adiposity -" @gregmushen on X 2025-07-25 21:57:41 UTC 24.1K followers, XX engagements
"@nntaleb Couldnt agree more. Theres also a risk of upregulation of glycolic reliance" @gregmushen on X 2025-07-21 21:42:48 UTC 24.1K followers, 7587 engagements
"Circadian rhythm governs the SCN or master clock. Incredibly important. But its not the only clock we have. We have other peripheral clocks. SCN signals these peripheral clocks but they also respond to independent stimuli such as food. 👇" @gregmushen on X 2025-07-22 23:41:56 UTC 24.1K followers, 9742 engagements
"At the highest dose something shifted. Not just labs but me. Suddenly I was listening to country music and had this strong urge to buy a vintage truck. And for some reason I started popping Zyns" @gregmushen on X 2025-04-14 01:29:00 UTC 24.1K followers, 69.2K engagements