[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Greg Mushen [@gregmushen](/creator/twitter/gregmushen) on x 24.2K followers Created: 2025-07-25 21:57:41 UTC I think what may be difficult to determine is a single cause. It could be a combination of factors that make it difficult to fuse table or associated a single cause. I think the root cause is caloric flux, but then describing in broad trends what’s caused that is likely multifactorial. - Decreased exercise - Increase reliance on processed food - More processed food means less fermentable fiber - Less fermentable fiber means less SCFA - Less SCFA means less FFAR2 signaling which then means less endogenous GLP-1/PYY, increased insulin resistance, less hormonal satiation, increased adiposity - Disrupted circadian rhythm from too much blue light at night. This can also disrupt satiation signaling and cause insulin issues. Although fiber may be a minor player here. Europeans eat around the same amount of fiber, but also about XXX calories less per day and they move more and eat less processed food. So I think the high level model is eating too much, eating too much processed food, not getting enough fiber, and disrupted circadian rhythm. Those I believe are the big levers, but determining what’s driving those there is a lot of detail and nuance. XX engagements  **Related Topics** [greg](/topic/greg) [Post Link](https://x.com/gregmushen/status/1948865264965353803)
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
Greg Mushen @gregmushen on x 24.2K followers
Created: 2025-07-25 21:57:41 UTC
I think what may be difficult to determine is a single cause. It could be a combination of factors that make it difficult to fuse table or associated a single cause.
I think the root cause is caloric flux, but then describing in broad trends what’s caused that is likely multifactorial.
- Decreased exercise
- Increase reliance on processed food
- More processed food means less fermentable fiber
- Less fermentable fiber means less SCFA
- Less SCFA means less FFAR2 signaling which then means less endogenous GLP-1/PYY, increased insulin resistance, less hormonal satiation, increased adiposity
- Disrupted circadian rhythm from too much blue light at night. This can also disrupt satiation signaling and cause insulin issues.
Although fiber may be a minor player here. Europeans eat around the same amount of fiber, but also about XXX calories less per day and they move more and eat less processed food.
So I think the high level model is eating too much, eating too much processed food, not getting enough fiber, and disrupted circadian rhythm.
Those I believe are the big levers, but determining what’s driving those there is a lot of detail and nuance.
XX engagements
Related Topics greg