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# ![@MichaelMindrum Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::957767862101438465.png) @MichaelMindrum Michael Mindrum, MD

Michael Mindrum, MD posts on X about weight loss the most. They currently have XXXXX followers and XX posts still getting attention that total XXXXXX engagements in the last XX hours.

### Engagements: XXXXXX [#](/creator/twitter::957767862101438465/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::957767862101438465/c:line/m:interactions.svg)

- X Month XXXXXX +190%
- X Months XXXXXXX -XX%
- X Year XXXXXXXXX +352%

### Mentions: X [#](/creator/twitter::957767862101438465/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::957767862101438465/c:line/m:posts_active.svg)


### Followers: XXXXX [#](/creator/twitter::957767862101438465/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::957767862101438465/c:line/m:followers.svg)

- X Month XXXXX +1.30%
- X Months XXXXX +5.70%
- X Year XXXXX +56%

### CreatorRank: XXXXXXX [#](/creator/twitter::957767862101438465/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::957767862101438465/c:line/m:influencer_rank.svg)

### Social Influence [#](/creator/twitter::957767862101438465/influence)
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**Social category influence**
[currencies](/list/currencies)  XXXX%

**Social topic influence**
[weight loss](/topic/weight-loss) XXXX%

**Top accounts mentioned or mentioned by**
[@drjohnm](/creator/undefined) [@drbrownboise](/creator/undefined) [@danieljdrucker](/creator/undefined) [@aliceyycheng](/creator/undefined) [@pritishiyer](/creator/undefined) [@pritish_iyer](/creator/undefined) [@soferyael1](/creator/undefined) [@nplusyears](/creator/undefined) [@joshjwageman](/creator/undefined)
### Top Social Posts [#](/creator/twitter::957767862101438465/posts)
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Top posts by engagements in the last XX hours

"Fantastic review in Nature on estrogen & the health of adipose tissue: "Health of adipose tissue: oestrogen matters""  
[X Link](https://x.com/MichaelMindrum/status/1979518154788520274) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T12:01Z 9722 followers, 21.9K engagements


"We increasingly understand obesity as a brain-based disease. This review by Zagmutt et al. 2025 maps how subtle inflammation in the hypothalamus evolves over time offering a clearer picture of when and how metabolic regulation begins to fail. 1/5"  
[X Link](https://x.com/MichaelMindrum/status/1980224009091579908) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-20T10:46Z 9721 followers, 34K engagements


"1. The Early Spark: within hours of high-fat feeding the hypothalamus shows local transient activation of glia and cytokines. Its an adaptive signalan early attempt to sense and buffer nutrient overload before systemic inflammation develops. 2/5"  
[X Link](https://x.com/MichaelMindrum/status/1980224013537567198) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-20T10:46Z 9722 followers, 1623 engagements


"Yet another mechanism of Metformin It boosts upper intestinal lipid sensing via a GIP ➡Nucleus Tractus Solitarus 🧠 axis to suppress feeding in 🐭. @DrBrownBoise @DanielJDrucker"  
[X Link](https://x.com/MichaelMindrum/status/1980660220356677643) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T15:39Z 9722 followers, 2040 engagements


"Does Tirzepatide reduce inflammation See for yourself 👀: below are the forest plots for CRP & IL-6 from a recent meta-analysis. Sorry @drjohnm no cutesy graphical abstracts for this paper 😢. Link to study next"  
[X Link](https://x.com/MichaelMindrum/status/1980719429962154431) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T19:34Z 9722 followers, 10.1K engagements


"Adolescents with Type X DM deserve well functioning brains Acute hyperglycemia led to widespread reduced cerebral perfusion and increased neural activity while hypoglycemia led to reduced neural activity with effects lasting XX min despite restoration of euglycemia"  
[X Link](https://x.com/MichaelMindrum/status/1979515473373868197) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T11:50Z 9683 followers, 1156 engagements


"FIB-4 score has become a main feature of many MASLD referral pathways. But how good is it "FIB-4-based referral pathways to identify liver disease among the general population result in a high referral rate while approximately XX% of LSM X kPa XX% of LSM XX kPa XX% of LSM XX kPa and XX% of incident advanced liver disease cases remain undetected.""  
[X Link](https://x.com/MichaelMindrum/status/1979510889830044054) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T11:32Z 9690 followers, 1282 engagements


"🧠 New review in Reviews in Endocrine & Metabolic Disorders: Hypothalamic astrocytes arent just brain support cells. They sense nutrients & hormones shape neuronal circuits and control glucose fat metabolism & circadian rhythms linking brain-body in metabolic health"  
[X Link](https://x.com/MichaelMindrum/status/1979657899883266253) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T21:16Z 9720 followers, 7099 engagements


"@pritish_iyer @drjohnm agree. would have been nice if they tried to parse out association of CRP reduction & weight loss. Certainly some mechanisms that can reduce inflammation independent of weight loss"  
[X Link](https://x.com/MichaelMindrum/status/1980727228360180175) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T20:05Z 9722 followers, XXX engagements