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[@MichaelMindrum](/creator/twitter/MichaelMindrum)
"Fantastic review in Nature on estrogen & the health of adipose tissue: "Health of adipose tissue: oestrogen matters""  
[X Link](https://x.com/MichaelMindrum/status/1979518154788520274) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T12:01Z 9756 followers, 22.2K engagements


"Does Tirzepatide reduce inflammation See for yourself 👀: below are the forest plots for CRP & IL-6 from a recent meta-analysis. Sorry @drjohnm no cutesy graphical abstracts for this paper 😢. Link to study next"  
[X Link](https://x.com/MichaelMindrum/status/1980719429962154431) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T19:34Z 9756 followers, 15.9K engagements


"🧠 New review in Reviews in Endocrine & Metabolic Disorders: Hypothalamic astrocytes arent just brain support cells. They sense nutrients & hormones shape neuronal circuits and control glucose fat metabolism & circadian rhythms linking brain-body in metabolic health"  
[X Link](https://x.com/MichaelMindrum/status/1979657899883266253) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-18T21:16Z 9752 followers, 7151 engagements


"1. The Early Spark: within hours of high-fat feeding the hypothalamus shows local transient activation of glia and cytokines. Its an adaptive signalan early attempt to sense and buffer nutrient overload before systemic inflammation develops. 2/5"  
[X Link](https://x.com/MichaelMindrum/status/1980224013537567198) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-20T10:46Z 9751 followers, 1725 engagements


"Yet another mechanism of Metformin It boosts upper intestinal lipid sensing via a GIP ➡Nucleus Tractus Solitarus 🧠 axis to suppress feeding in 🐭. @DrBrownBoise @DanielJDrucker"  
[X Link](https://x.com/MichaelMindrum/status/1980660220356677643) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T15:39Z 9752 followers, 2225 engagements


"@pritish_iyer @drjohnm agree. would have been nice if they tried to parse out association of CRP reduction & weight loss. Certainly some mechanisms that can reduce inflammation independent of weight loss"  
[X Link](https://x.com/MichaelMindrum/status/1980727228360180175) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-21T20:05Z 9754 followers, XXX engagements


"We increasingly understand obesity as a brain-based disease. This review by Zagmutt et al. 2025 maps how subtle inflammation in the hypothalamus evolves over time offering a clearer picture of when and how metabolic regulation begins to fail. 1/5"  
[X Link](https://x.com/MichaelMindrum/status/1980224009091579908) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-20T10:46Z 9756 followers, 36K engagements


"If you don't have type X DM please put away your CGM. Why There is no correlation between CGM metrics and A1c in the non-diabetic population. 1/3"  
[X Link](https://x.com/MichaelMindrum/status/1981521787297886576) [@MichaelMindrum](/creator/x/MichaelMindrum) 2025-10-24T00:43Z 9756 followers, 1343 engagements