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[@JacobPlieth](/creator/twitter/JacobPlieth)
"A Bardia confirms: no deaths on datopotamab dxd in Tropion-Breast01 but one ILD gr X was later reanalysed and regraded gr X () $DSNKY $AZN"  
[X Link](https://x.com/JacobPlieth/status/1716465515919516008) [@JacobPlieth](/creator/x/JacobPlieth) 2023-10-23T14:44Z 30.9K followers, 7174 engagements


"$BGNE vs $NRIX in BTG degradation. I can't remember the last time I saw two separate datasets yield results that look so similar #ASH24"  
[X Link](https://x.com/JacobPlieth/status/1866630560355061773) [@JacobPlieth](/creator/x/JacobPlieth) 2024-12-10T23:46Z 30.9K followers, 7600 engagements


"So the ILD grading shenanigans continue. Here's another grade X event adjudicated as grade X ILD $DSNKY $AZN #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979850770834141407) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T10:03Z 30.9K followers, 2812 engagements


"@ohadhammer Apparently no PFS data on torvuta-S which $AZN had promised in the #ESMO25 abstract"  
[X Link](https://x.com/JacobPlieth/status/1979878792685666503) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T11:54Z 30.9K followers, XXX engagements


"So. no $MRNA activity in PD-L1-negatives looks like a win for $IOBT no #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1977690767574413571) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T10:59Z 30.9K followers, 10.9K engagements


"First human data for a DNA pol theta inhibitor Artios's ART6043 +/-Lynparza in solid tumours shows X cPR + X uCR. via Tim Yap #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979195138388754918) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-17T14:37Z 30.9K followers, 6920 engagements


"Novel synthetic lethality approaches from Synnovation Artios & $NVS leave much to prove. Via @ApexOnco at #ESMO25 - $IDYA $RPTX $GSK"  
[X Link](https://x.com/JacobPlieth/status/1979589418492063916) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T16:44Z 30.9K followers, 2909 engagements


"And here's one of the last two men standing in #tigit $RCUS $GILD domvanalimab: first disclosure of OS curves from Edge-Gastric via Yelena Janjigian #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979593749672915069) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T17:01Z 30.9K followers, 2654 engagements


"Something tells me $GMAB is about to get eclipsed in folate receptor alpha ADC $LLY $AZN #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979890827871896039) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T12:42Z 30.9K followers, 3338 engagements


"#ESMO25 regular abstracts are now live with first-in-human data being revealed by $LLY $INCY $DSNKY $MRNA $NVS Parabilis & others. Preview via @ApexOnco"  
[X Link](https://x.com/JacobPlieth/status/1977743598129926308) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T14:29Z 30.9K followers, 6401 engagements


"First patient now dosed in this study of TUB-040 Tubulis says. Relevant for $ZYME $ADCT $MRSN & MediLink"  
[X Link](https://x.com/JacobPlieth/status/1803793531779059837) [@JacobPlieth](/creator/x/JacobPlieth) 2024-06-20T14:14Z 30.9K followers, 4385 engagements


"#WCLC25 late-breaker & plenary preview via @ApexOnco $SMMT $BMY $BNTX $NUVL $CGEM"  
[X Link](https://x.com/JacobPlieth/status/1958202262183940590) [@JacobPlieth](/creator/x/JacobPlieth) 2025-08-20T16:19Z 30.9K followers, 17.1K engagements


"Wow so $AMGN slipped out that bemarituzumab's positive final OS analysis slipped into negative territory at longer follow-up. $ZLAB off X% yesterday -X% premarket today"  
[X Link](https://x.com/JacobPlieth/status/1963525096221364576) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-04T08:50Z 30.9K followers, 8712 engagements


"LOL that was quick"  
[X Link](https://x.com/JacobPlieth/status/1971573097573851440) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-26T13:50Z 30.9K followers, 18.2K engagements


"Keep them coming big pharma $AZN"  
[X Link](https://x.com/JacobPlieth/status/1976560869464039797) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-10T08:10Z 30.9K followers, 3195 engagements


"$MRNA mRNA-4359 at #ESMO25: ORR XX% (n=9) but no activity at all in PD-L1 non-expressers (n=13) $IOBT"  
[X Link](https://x.com/JacobPlieth/status/1977669398149427663) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T09:35Z 30.9K followers, 3625 engagements


"@avidresearch One caveat is $IOBT is 1st-line whereas $MRNA is checkpoint-refractory but PD-L1-negative comps are probably accurate #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1977713645841731736) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T12:30Z 30.9K followers, 1459 engagements


"$LLY (ex Mablink) anti-FR ADC LY4170156 starts phase X this month $ABBV $GMAB $STRO"  
[X Link](https://x.com/JacobPlieth/status/1787773937142653204) [@JacobPlieth](/creator/x/JacobPlieth) 2024-05-07T09:18Z 30.9K followers, 3720 engagements


"Catching up on some #ASCO25 sessions I came across this on dual-payload ADCs from Patricia LoRusso's clinical science symposium"  
[X Link](https://x.com/JacobPlieth/status/1930975237924893057) [@JacobPlieth](/creator/x/JacobPlieth) 2025-06-06T13:09Z 30.9K followers, 6706 engagements


"More doubts for $SMMT as the Harmoni guessing game continues at #WCLC25. Via @ApexOnco - $BNTX $TIL $BMY"  
[X Link](https://x.com/JacobPlieth/status/1964771632154812790) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-07T19:23Z 30.9K followers, 11.4K engagements


"Is this a world record Seven days from data toplining to appearance in an #ESMO25 late-breaker $AZN"  
[X Link](https://x.com/JacobPlieth/status/1977658793690591360) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T08:52Z 30.9K followers, 3612 engagements


"Almost the last #tigit standing: $RCUS $GILD domvanalimab flies the flag at #ESMO25. Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1979801959264866426) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T06:49Z 30.9K followers, 2865 engagements


"Meanwhile here's $AZN FR ADC torvutatug samrotecan in first-in-human Fontana study. No clear cut by FR expression #ESMO25 via Ana Oaknin"  
[X Link](https://x.com/JacobPlieth/status/1979834467411010011) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T08:58Z 30.9K followers, 1477 engagements


"Fascinating Evercore ISI webinar going on right now about disconnect between value of Sino deal and what $MRK owes Lanova on the PD-1 x VEGF. In summary: XX% of $588m MRK up front and XX% of the $300m tech transfer actually went to Genscript () $LEGN"  
[X Link](https://x.com/JacobPlieth/status/1946199171704242199) [@JacobPlieth](/creator/x/JacobPlieth) 2025-07-18T13:23Z 30.9K followers, 11.4K engagements


"In 2023 $NVS paid $LEGN $100m for an anti-DLL3 Car-T. First human data at #WCLC25 show that this still a work in progress. Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1965744103523811398) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-10T11:48Z 30.9K followers, 5834 engagements


"First $AFMD now $IPHA. what say $ONC & any others still involved in NK-cell engagers"  
[X Link](https://x.com/JacobPlieth/status/1968302921881370818) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-17T13:16Z 30.9K followers, 5042 engagements


"New players in dual-payload ADCs: Lonza Synaffix & Qurient Therapeutics. CDK7 inhibitor"  
[X Link](https://x.com/JacobPlieth/status/1971118656919830596) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-25T07:44Z 30.9K followers, 2127 engagements


"Did the FDA tell $IOBT not to file because Keynote-D18 (technically) failed or because it enrolled only XX US patients"  
[X Link](https://x.com/JacobPlieth/status/1972628599963611422) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-29T11:44Z 30.9K followers, 2693 engagements


"V early solid tumour data for Synnovation's Parp1 inhibitor SNV1521 via Pat LoRusso #ESMO25 $AZN $GILD $MKGAF"  
[X Link](https://x.com/JacobPlieth/status/1979193474214670481) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-17T14:31Z 30.9K followers, 2846 engagements


"New phase X Parp1 inhibitor from Synnovation $MKGAF $GILD $AZN"  
[X Link](https://x.com/JacobPlieth/status/1752324510047498715) [@JacobPlieth](/creator/x/JacobPlieth) 2024-01-30T13:34Z 30.9K followers, 7658 engagements


"43 patients' worth of data = $8bn of which $5.5bn is being financed through debt $MRUS $GMAB"  
[X Link](https://x.com/JacobPlieth/status/1972611899255873631) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-29T10:38Z 30.9K followers, 16.6K engagements


"#ESMO25 Sunday late-breakers: LBA20 - $GILD Ascent-03 "One LBA TBC" LBA21 - unassigned $DSNKY $AZN"  
[X Link](https://x.com/JacobPlieth/status/1975117046531977337) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-06T08:32Z 30.9K followers, 6991 engagements


"Now $BMY buys Orbital for. $1.5bn Focus seems to be autoimmune but pipeline also includes some oncology work $AZN $ABBV $GILD $SNY $ALPMF"  
[X Link](https://x.com/JacobPlieth/status/1976608534839357772) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-10T11:19Z 30.9K followers, 14.3K engagements


"Napistar1-01 data from Tubulis's TUB-040 coming at an #ESMO25 late-breaker. Meanwhile Tubulis just closed a 308m series C which it claims is the largest series C for a European biotech ever"  
[X Link](https://x.com/JacobPlieth/status/1978393122263412923) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-15T09:30Z 30.9K followers, 5033 engagements


"How bad was $RHHBY Skyscraper-07 Adding Tigit to PD-L1 + chemo actually shortened survival (prob owing to more AEs). Question now: does Tecentriq + chemo (without tira) have a future in this setting #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1978736114006388877) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-16T08:13Z 30.9K followers, 3365 engagements


"PD-1 x VEGF news: Shanghai Junshi says it's got FDA approval to start a US ph2/3 trial of JS207 head-to-head vs Opdivo in neoadjuvant NSCLC $SMMT $TIL $BNTX"  
[X Link](https://x.com/JacobPlieth/status/1978809705532203166) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-16T13:06Z 30.9K followers, 7414 engagements


"Meanwhile here's Skyscraper-03 stage III NSCLC. #tigit combo is no better than Imfinzi but adds tox. No attempt by Rafal Dziaduszko to gloss over how bad these data are #ESMO25 $RHHBY $RCUS $GILD $AZN"  
[X Link](https://x.com/JacobPlieth/status/1979572793869017474) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T15:38Z 30.9K followers, 2182 engagements


"@raffcolo You saw this detail Gr5 events include X x ILD X x respiratory tract infection X x acute respiratory faillure X x ARDS. Adjuvant setting $DSNKY $AZN #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979573764791652681) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T15:42Z 30.9K followers, XXX engagements


"How did $AZN Potomac readout match $PFE Crest almost number for number Plus a #sadtrombone for Tecentriq in $RHHBY Alban from #ESMO25 yesterday via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1979589056502841635) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T16:43Z 30.9K followers, 2348 engagements


"Someone at $AZN might be getting fired for failing to organise a standing ovation for Destiny-Breast05 & XX #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979599455071478251) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-18T17:24Z 30.9K followers, 14.8K engagements


"Pretty decent #ESMO25 data for $LLY Mablink-derived FR ADC LY4170156 which is about to go into phase X. XX% ORR in FR 0-24% expressers $GILD $ABBV $AZN"  
[X Link](https://x.com/JacobPlieth/status/1979811830295040264) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T07:28Z 30.9K followers, 5960 engagements


"Does this mean $MRUS $GMAB is screwed"  
[X Link](https://x.com/JacobPlieth/status/1979919452788380074) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T14:35Z 30.9K followers, 14.2K engagements


"@NotGenentech Unfortunately 120mg/m2 is the only one where $GMAB can claim activity "regardless of FR expression""  
[X Link](https://x.com/JacobPlieth/status/1979921653711642743) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T14:44Z 30.9K followers, XXX engagements


"Fun facts from the #ESMO25 exhibition hall: $BNTX booth is almost next to $SMMT $IOBT booth is at least twice as big as $MRNA Menarini booth is FREAKIN HUGE"  
[X Link](https://x.com/JacobPlieth/status/1979935091842236885) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T15:38Z 30.9K followers, 6405 engagements


"If you didn't already feel sorry for $IOBT check this out. Presumably paid for before XX Sep #ESMO25"  
[X Link](https://x.com/JacobPlieth/status/1979980409707307083) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-19T18:38Z 30.9K followers, 3212 engagements


"From #ESMO25 yesterday via @ApexOnco - how $LLY sprang a surprise for $AZN in FR. Also key datasets for $GMAB"  
[X Link](https://x.com/JacobPlieth/status/1980166382575894819) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-20T06:57Z 30.9K followers, 1884 engagements


"Hopefully more Harmoni-3 details on today's $SMMT investor call"  
[X Link](https://x.com/JacobPlieth/status/1980175849904042087) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-20T07:34Z 30.9K followers, 2739 engagements


"Radiance Biopharma has links to $SGEN and last year licensed Biocytogen's anti-HER2 x TROP2 bispecific ADC YH012/RB-201. Now it's the latest to get into ROR1 $IPN.PA $STRO $ZLAB $ZNTL $IMNM"  
[X Link](https://x.com/JacobPlieth/status/1892149793750741233) [@JacobPlieth](/creator/x/JacobPlieth) 2025-02-19T09:50Z 30.9K followers, 3568 engagements


"You already have a small-molecule inhibitor so do you also need a degrader $ONC $BGNE thinks yes for BTK CDK2 & Kras. Via @ApexOnco - $ARVN $GILD $RVMD"  
[X Link](https://x.com/JacobPlieth/status/1939696857925533733) [@JacobPlieth](/creator/x/JacobPlieth) 2025-06-30T14:45Z 30.9K followers, 4695 engagements


"Plus some other #WCLC25 presentations of note: $LEGN $TIL $NVS $BNTX $CADL"  
[X Link](https://x.com/JacobPlieth/status/1958616455509155996) [@JacobPlieth](/creator/x/JacobPlieth) 2025-08-21T19:45Z 30.9K followers, 5331 engagements


"Remember that $MRNA mRNA-encoded triple T-cell engagers therapy vs BCMA FcRH5 & GPRC5D from #ASH24 It could be mRNA-2808"  
[X Link](https://x.com/JacobPlieth/status/1958850386745344176) [@JacobPlieth](/creator/x/JacobPlieth) 2025-08-22T11:15Z 30.9K followers, 9210 engagements


"Interesting take on the FcRH5 landscape which seems to be one of $RHHBY's main oncology R&D areas of interest. $MRNA & $LEGN active here"  
[X Link](https://x.com/JacobPlieth/status/1970769553572454869) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-24T08:37Z 30.9K followers, 4482 engagements


"#ESMO25 late-breaker LBA53 but now $IOBT says it can't file on IOB-013 study"  
[X Link](https://x.com/JacobPlieth/status/1972619740578521276) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-29T11:09Z 30.9K followers, 15.6K engagements


"$IOBT (-75% this am) $LPTX $CELC & some other #ESMO25 late breakers via @ApexOnco $EXEL $RHHBY $AZN"  
[X Link](https://x.com/JacobPlieth/status/1972666229681713650) [@JacobPlieth](/creator/x/JacobPlieth) 2025-09-29T14:14Z 30.9K followers, 3656 engagements


"Especially for the science nerds I looked at $AZN's latest attempt at CD8-guided T-cell engagement which seems to be a new take on the Titan planform. Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1973733499749421391) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-02T12:55Z 30.9K followers, 4557 engagements


"So basically $SNY is a pioneer"  
[X Link](https://x.com/JacobPlieth/status/1976617227169489195) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-10T11:54Z 30.9K followers, 5738 engagements


"@jeromeleonard5 @NotthatkindofDr GSK4418959 / IDE275 I was kind of hoping to see FIH data on that at #ESMO25 $GSK $IDYA"  
[X Link](https://x.com/JacobPlieth/status/1977739462793674925) [@JacobPlieth](/creator/x/JacobPlieth) 2025-10-13T14:13Z 30.9K followers, XXX engagements