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# ![@JacobPlieth Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::873399943.png) @JacobPlieth Jacob Plieth

Jacob Plieth posts on X about $jnj, $onc, $nrix, $azn the most. They currently have XXXXXX followers and XX posts still getting attention that total XXXXXX engagements in the last XX hours.

### Engagements: XXXXXX [#](/creator/twitter::873399943/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::873399943/c:line/m:interactions.svg)

- X Week XXXXXX +127%
- X Month XXXXXXX +15%
- X Months XXXXXXXXX +57%
- X Year XXXXXXXXX -XX%

### Mentions: XX [#](/creator/twitter::873399943/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::873399943/c:line/m:posts_active.svg)

- X Week XX -XX%
- X Month XXX -XX%
- X Months XXX +49%
- X Year XXX -X%

### Followers: XXXXXX [#](/creator/twitter::873399943/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::873399943/c:line/m:followers.svg)

- X Week XXXXXX +0.22%
- X Month XXXXXX +0.78%
- X Months XXXXXX +6.20%
- X Year XXXXXX +12%

### CreatorRank: XXXXXXX [#](/creator/twitter::873399943/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::873399943/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[stocks](/list/stocks)  #4851 [cryptocurrencies](/list/cryptocurrencies)  #3100 [currencies](/list/currencies)  #1836 [countries](/list/countries)  XXXX% [social networks](/list/social-networks)  XXXX% [technology brands](/list/technology-brands)  XXXX%

**Social topic influence**
[$jnj](/topic/$jnj) #1, [$onc](/topic/$onc) #1, [$nrix](/topic/$nrix) #1, [$azn](/topic/$azn) #3, [$aclx](/topic/$aclx) #1, [$bgne](/topic/$bgne) #1, [$lly](/topic/$lly) #9, [$smmt](/topic/$smmt) #11, [china](/topic/china) 5.45%, [$eras](/topic/$eras) XXXX%

**Top accounts mentioned or mentioned by**
[@apexonco](/creator/undefined) [@avidresearch](/creator/undefined) [@ablt315i](/creator/undefined) [@bllphd](/creator/undefined) [@bymadeleinea](/creator/undefined) [@jfais20](/creator/undefined) [@s86coffeedev](/creator/undefined) [@houndcl](/creator/undefined) [@financebully](/creator/undefined) [@bananaoncology](/creator/undefined) [@hothomaswphelps](/creator/undefined) [@kinatsofrim](/creator/undefined) [@biotwit1](/creator/undefined) [@chuminhua432](/creator/undefined) [@charlene_liao](/creator/undefined) [@hall8jack](/creator/undefined) [@learnbiotech](/creator/undefined)

**Top assets mentioned**
[Johnson & Johnson (JNJ)](/topic/$jnj) [One Cash (ONC)](/topic/$onc) [AstraZeneca PLC (AZN)](/topic/$azn) [Arcellx, Inc. Common Stock (ACLX)](/topic/$aclx) [Eli Lilly and Company (LLY)](/topic/$lly) [Summit Therapeutics Inc. Common Stock (SMMT)](/topic/$smmt) [Pfizer, Inc. (PFE)](/topic/$pfe) [Terns Pharmaceuticals, Inc. Common Stock (TERN)](/topic/$tern) [Dawn Protocol (DAWN)](/topic/$dawn) [Revolution Medicines, Inc. Common Stock (RVMD)](/topic/$rvmd) [AbbVie Inc (ABBV)](/topic/$abbv) [Bristol-Myers Squibb Co (BMY)](/topic/$bmy) [Regeneron Pharmaceuticals Inc (REGN)](/topic/$regn) [Amgen, Inc. (AMGN)](/topic/$amgn) [Merus N.V. Common Shares (MRUS)](/topic/$mrus) [Gilead Sciences, Inc. (GILD)](/topic/$gild) [Merck & Co., Inc. (MRK)](/topic/$mrk) [Incyte Corporation (INCY)](/topic/$incy) [Jazz Pharmaceuticals, Inc. (JAZZ)](/topic/$jazz) [Novartis AG (NVS)](/topic/$nvs)
### Top Social Posts
Top posts by engagements in the last XX hours

"By my calculation $ONC now has an efficacy edge vs $NRIX in BTK degradation. Caveats: small pt numbers X-trial comparison and Nurix might have the safety advantage #ASH25"  
[X Link](https://x.com/JacobPlieth/status/1997987562455978162)  2025-12-08T11:12Z 31.3K followers, 2419 engagements


"Gammadelta T cells FTW $IPN.PA buying Imcheck for EUR350m. Approach seems not dissimilar to the now departed $LVTX"  
[X Link](https://x.com/JacobPlieth/status/1980879929551249747)  2025-10-22T06:12Z 31.3K followers, 11.8K engagements


"@avidresearch OS even with slightly fugly crossover gives HR=0.46 $JNJ #ASH25 As ever infection risk is very real with CD3-targeting T-cell engagers"  
[X Link](https://x.com/JacobPlieth/status/1998378872644239490)  2025-12-09T13:07Z 31.3K followers, XXX engagements


"$BGNE vs $NRIX in BTG degradation. I can't remember the last time I saw two separate datasets yield results that look so similar #ASH24"  
[X Link](https://x.com/JacobPlieth/status/1866630560355061773)  2024-12-10T23:46Z 31.3K followers, 9737 engagements


"So basically since I wrote this in Jan 2024 the $SGN $PFE patent was "revalidated" and it's just been invalidated again"  
[X Link](https://x.com/JacobPlieth/status/1996177907098730653)  2025-12-03T11:21Z 31.3K followers, 4287 engagements


"$NRIX +23% surprises me. I thought the #ASH25 data showed $ONC to be better on efficacy (with caveats) albeit worse on safety. My earlier take on @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1998055411392327821)  2025-12-08T15:41Z 31.3K followers, 4767 engagements


"Wow check out the $JNJ Tecvayli survival curves in Majestec-3 #ASH25"  
[X Link](https://x.com/JacobPlieth/status/1998377670745403427)  2025-12-09T13:02Z 31.3K followers, 6027 engagements


"$JNJ Tecvayli (& $LEGN Carvykti) "entering a new era of resetting survival expectations in a cancer historically described as incurable". @ByMadeleineA @ApexOnco from #ASH25 on Majestec-3 $ACLX $BMY"  
[X Link](https://x.com/JacobPlieth/status/1998378577856000306)  2025-12-09T13:05Z 31.3K followers, 5082 engagements


"@avidresearch Wait until you see $AZN CD8-based T-cell engagers (Perhaps.)"  
[X Link](https://x.com/JacobPlieth/status/1998380081580736772)  2025-12-09T13:11Z 31.3K followers, 1349 engagements


"If you enjoyed #ASH25 you can catch up on all @ApexOnco coverage including previews here - $TERN $JNJ $LLY $CGEM $ONC $NRIX $PFE $REGN $KURA"  
[X Link](https://x.com/JacobPlieth/status/1998402569991778378)  2025-12-09T14:41Z 31.3K followers, 3033 engagements


"$SMMT just dropping this one in casually. Note Akeso cadonilimab (PD-L1 x CTLA-4) was approved in China in Jun 2022"  
[X Link](https://x.com/JacobPlieth/status/1796305180834529615)  2024-05-30T22:18Z 31.3K followers, 13.5K engagements


"PD-1 x VEGF meet CD47 Ivonescimab +/- ligufalimab + chemo in 1L (not dMMR) colorectal. XX% ORR. China study obv. Via Yanhong Deng #ESMO24 $SMMT $BNTX"  
[X Link](https://x.com/JacobPlieth/status/1834956549187330553)  2024-09-14T14:05Z 31.3K followers, 23.1K engagements


"$AMGN Fortitude-101 study of bemarituzumab (ex $FPRX) + chemo is stat sig "& clinically meaningful" for OS vs chemo alone. FGFR2boverexpression (10% @ IHC 2+/3+) was enrolment criterion I believe so this is a hit on ITT. $TYRA"  
[X Link](https://x.com/JacobPlieth/status/1939672763452539098)  2025-06-30T13:09Z 31.3K followers, 2826 engagements


"Does this mean $MRUS $GMAB is screwed"  
[X Link](https://x.com/JacobPlieth/status/1979919452788380074)  2025-10-19T14:35Z 31.3K followers, 16.1K engagements


"Why have not one but two VC firms now bought into anti-TROP2 ADC development @ApexOnco take on $GILD & $MRK's atypical tie-ups"  
[X Link](https://x.com/JacobPlieth/status/1986078802972443118)  2025-11-05T14:31Z 31.3K followers, 3647 engagements


"$DAWN to the rescue $MRSN"  
[X Link](https://x.com/JacobPlieth/status/1988930213800194362)  2025-11-13T11:21Z 31.3K followers, 10.9K engagements


"What has $DAWN seen in $MRSN Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1988963230740541530)  2025-11-13T13:32Z 31.3K followers, 3332 engagements


"$ERAS David Chacko reiterating timelines for ERAS-0015 & ERAS-4001: first ph1 monorx dose-escalation data for both expected in calendar 2026 #Jefferies25"  
[X Link](https://x.com/JacobPlieth/status/1991094261455228941)  2025-11-19T10:40Z 31.3K followers, 2209 engagements


"Each will comprise "dozens of patients". Goal for ERAS-0015 is "comparable" safety to $RVMD and comparable efficacy at say half daraxonrasib dose $ERAS #Jefferies25"  
[X Link](https://x.com/JacobPlieth/status/1991096938813603863)  2025-11-19T10:51Z 31.3K followers, 1988 engagements


"@s86CoffeeDev @houndcl @financebully @avidresearch @Banana_Oncology $ERAS says ERAS-0015 uses different scaffold vs daraxonrasib. Not sure if that circumvents $RVMD patent"  
[X Link](https://x.com/JacobPlieth/status/1991103568095691052)  2025-11-19T11:17Z 31.3K followers, XXX engagements


"Akeso and $IVBXF are up at #Jefferies25 shortly. Presentations not being webcast so I'll try to tweet out anything relevant"  
[X Link](https://x.com/JacobPlieth/status/1991168947341914501)  2025-11-19T15:37Z 31.3K followers, 2430 engagements


"Wow the Jefferies analyst really has the Akeso CFO on the ropes with her first question: "Everyone is talking about China out-licensing and it's all down to you; how do you achieve such greatness" #Jefferies25"  
[X Link](https://x.com/JacobPlieth/status/1991175408645992537)  2025-11-19T16:03Z 31.3K followers, 9441 engagements


"Akeso CFO Bing Wang: we see ivo replacing $MRK Keytruda as the anchor across several settings. Biggest market is NSCLC - anchor there w/multiple combos then expand beyond #Jefferies25 $SMMT $BNTX"  
[X Link](https://x.com/JacobPlieth/status/1991177218161078738)  2025-11-19T16:10Z 31.3K followers, 7288 engagements


"Akeso must be one of the last fans of CD47 still standing: adding ligufalinab to ivo in head & neck doubles the ORR CFO Bing Wang tells #Jefferies25 $ALXO"  
[X Link](https://x.com/JacobPlieth/status/1991178084360355965)  2025-11-19T16:13Z 31.3K followers, 2111 engagements


"Akeso reminds #Jefferies25 that cadonilimab (like ivonescimab) is tetravalent: X binders each for PD-1 & CTLA-4"  
[X Link](https://x.com/JacobPlieth/status/1991179385395654837)  2025-11-19T16:18Z 31.3K followers, 2654 engagements


"Akeso claims cadonilimab is safest in class as well as first in class PD-1 x CTLA-4. So dissing $AZN (notoriously toxic) volrustomig #Jefferies25"  
[X Link](https://x.com/JacobPlieth/status/1991181439606411514)  2025-11-19T16:27Z 31.3K followers, 1872 engagements


"If you need some biotech reading over Thanksgiving check out @ApexOnco previews of #ASH25 -- Starts in just over a week $ACLX $ONC $CRVS $TERN $KURA $SNDX $CGEM $INCY"  
[X Link](https://x.com/JacobPlieth/status/1994037961198129381)  2025-11-27T13:37Z 31.3K followers, 5839 engagements


"$1.7bn valuation stock +75% YTD $IMNM eyes $SWTX's success. What does varegacestat need to hit in Ringside Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1994311772631679455)  2025-11-28T07:45Z 31.3K followers, 8382 engagements


"GC511B appears to be an $AZN Car-T therapy against DLL3. Can anyone corroborate"  
[X Link](https://x.com/JacobPlieth/status/1994427702766375073)  2025-11-28T15:26Z 31.3K followers, 3881 engagements


"$JAZZ Ziihera data from Herizon-GEA-01 study coming at #GI26"  
[X Link](https://x.com/JacobPlieth/status/1996123710219006025)  2025-12-03T07:45Z 31.3K followers, 2446 engagements


"@avidresearch Be fair though that's actually not saying a lot LOL"  
[X Link](https://x.com/JacobPlieth/status/1996266117610774772)  2025-12-03T17:11Z 31.3K followers, 2248 engagements


"Jaypirca shocker XX% crossover in confirmatory Bruin CLL-321 trial - obviously unavoidable and obviously trashes the OS benefit. $LLY toplined it positive for PFS which will surely confirm approval. Via Jeff Sharman #ASH24 $BGNE $ABBV $AZN $JNJ"  
[X Link](https://x.com/JacobPlieth/status/1866265319452360786)  2024-12-09T23:35Z 31.3K followers, 13.3K engagements


"$BGNE -XX% $NRIX +8%. I'm puzzled. #ASH24 data:"  
[X Link](https://x.com/JacobPlieth/status/1866510710269935712)  2024-12-10T15:50Z 31.3K followers, 16K engagements


"In 2023 $NVS paid $LEGN $100m for an anti-DLL3 Car-T. First human data at #WCLC25 show that this still a work in progress. Via @ApexOnco -"  
[X Link](https://x.com/JacobPlieth/status/1965744103523811398)  2025-09-10T11:48Z 31.3K followers, 5920 engagements


"Just accepted for FDA priorty review. "The treatment was well tolerated and the risks were manageable" so that's all right then $ONC"  
[X Link](https://x.com/JacobPlieth/status/1993638759502323816)  2025-11-26T11:11Z 31.3K followers, 8510 engagements


"$LLY Jaypirca looks best. up to a point. Via @ApexOnco from #ASH25 $ONC $AZN $JNJ $ABBV $NRIX"  
[X Link](https://x.com/JacobPlieth/status/1998373428114624578)  2025-12-09T12:45Z 31.3K followers, 3506 engagements


"@ablT315I And. here come the sellside notes defending $ACLX"  
[X Link](https://x.com/JacobPlieth/status/1998441028085338596)  2025-12-09T17:14Z 31.3K followers, XXX engagements


"What a stinker of an #ASH25 for $ACLX -XX% since Nov abstract drop. Inconsequential Immagine-1 update while others making huge strides"  
[X Link](https://x.com/JacobPlieth/status/1998445251929702548)  2025-12-09T17:30Z 31.3K followers, 4282 engagements