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@gregmushen "@Tuluminati888 Love that. Ill see you in Wonderland 🫡"
@gregmushen on X 2025-07-26 19:56:46 UTC 24.2K followers, XX engagements

"What happens to gut health on Keto/Carnivore Can you still have a health gut"
@gregmushen on X 2025-07-26 01:58:16 UTC 24.2K followers, 14.2K engagements

"Branched SCFA (BCFA) BCFA is a marker of protein fermentation. While it is similar chemically to SCFA but a weak agonist of FFAR2 The problem is BCFA arent a harmless byproduct. They are associated with ammonia p-cresol and biogenic amines. They are potentially cytotoxic and pro inflammatory to colonocytes"
@gregmushen on X 2025-07-26 01:58:27 UTC 24.2K followers, 1193 engagements

"@DrRyanPDaly Oh nice. I will have to look into this. Have been researching different fibers and believe Ive figured out how to synthesize RS5 in my kitchen"
@gregmushen on X 2025-07-26 18:10:07 UTC 24.2K followers, XX engagements

"Yes. In short in order to have the healthiest microbiome you need the proper colonic pH which is all but impossible to achieve on carnivore. Fiber particularly fermentable fiber which produce SCFA like butyrate which will bring this pH down to a range where we can have a diverse and healthy microbiome. But fiber also does so much more I included around five specific microbiome related studies in the thread. There are reams of studies on fiber itself. And theres this study which just says it plainly"
@gregmushen on X 2025-07-23 14:29:45 UTC 24.2K followers, XX engagements

"Summary - Butyrate drops XX percent - Colonocytes starve and trigger autophagy - BHB is not butyrate - Colon pH rises favoring proteolytic bacteria - Branched chain SCFA ammonia and ImP increase - Mucin fermentation cannot keep up - Zonulin rises the barrier breaks"
@gregmushen on X 2025-07-26 01:58:28 UTC 24.2K followers, 1071 engagements

"Since butyrate production is low there is a fallback mechanism: mucin or the gut lining. Some butyrate is needed for ATP for colonocytes. Colonocytes get around XX% of their ATP from butyrate. Taxa such as Akkermansia can ferment mucin to butyrate"
@gregmushen on X 2025-07-28 04:12:59 UTC 24.2K followers, XXX engagements

"@BowTiedGatorDDS Seems to be the case. At any rate Im going to develop an animal based fiber supplement for the carnivore community. As one does. Lets burn this down"
@gregmushen on X 2025-07-23 04:30:00 UTC 24.2K followers, XXX engagements

"Pathogens and inflammatory tone Higher pH oxygen leakage and nitrate favor Proteobacteria as mentioned (E. coli Salmonella). Their LPS and flagellin sustain a low grade inflammatory tone and metabolic endotoxemia"
@gregmushen on X 2025-07-28 04:13:10 UTC 24.2K followers, XXX engagements

"How To Construct a Fiber Heavy Tsimane Diet To get 70g of fiber and 55g of resistant starch this is what a day of eating would look like: - 350g green plantain (boiled and cooled) - 400g red potato (cooked and cooled) - 300g jasmine rice (cooked and cooled) - 250g pinto beans (pressure cooked) - 150g of blueberries - 200g of mixed vegetables - 30g of raw mixed nuts - 390g of chicken - X tbsp of olive oil Macros Calories: 2665 Protein: 161g Carbohydrate: 347g Fat: 43g Fiber: 70g Resistant starch: 55g This would be a propionate rich SCFA profile like the Tsimane"
@gregmushen on X 2025-07-27 00:58:30 UTC 24.2K followers, 16K engagements

"I could say the sky is blue. And a gaggle of carnivores* would come in to correct me. * defined as those who form their identity around the diet not those who can have rational conversations and engage in nuance. Not talking about them"
@gregmushen on X 2025-07-24 16:35:40 UTC 24.1K followers, 1943 engagements

"@ManjelievskaiaJ Oh cool. Wouldnt have expected that to be at a Dolly Parton gift shop"
@gregmushen on X 2025-07-27 20:17:56 UTC 24.2K followers, XX engagements

"The more I look into the microbiome and what it responds to the more it makes me think that most of the plants we evolved to eat are lost. The fibers are microbiome responds to well appear to be somewhat rare. Green bananas chicory root plantains guar gum acacia inulin from tubers beta glucan from oats. These resemble wild like plants bark roots unripe starches cooked starches that were roasted on a fire to be edible and then later cooled rhizomes (tumeric ginger galangal etc.) etc. Could explain both why some people dont do well on fiber and also why just adding more fiber without the"
@gregmushen on X 2025-07-26 19:33:48 UTC 24.2K followers, 18.7K engagements

"Can you still get all your nutrients from food A common belief is that our food supply is too depleted and that hitting all your micros from food alone is nearly impossible. That can be true if youre not tracking micros and not being intentional with your food selection. But if you do track and build your meals around nutrient density its absolutely possible. Personally Ive been tracking my micronutrients and consistently hitting all targets from food alone except for vitamin D (VDR polymorphism and low light Seattle) and B vitamins (MTRR polymorphism). My go to for magnesium is a daily"
@gregmushen on X 2025-06-08 17:46:27 UTC 24.2K followers, 31.6K engagements

"@CoffeeBlackMD Haha. True. I was too lazy to make filtered coffee as well and I noticed unfiltered impacts my lipids. Ugh tradeoffs"
@gregmushen on X 2025-05-26 17:55:54 UTC 24.2K followers, 1123 engagements

"A FFAR2 agonist peptide would be 🔥 FFAR2 inhibits adipocyte lipolysis increases PYY and GLP-1 endogenously would help restore gut barrier function could reduce visceral adipose inflammation and modulate immune function. Or you could just eat more fiber"
@gregmushen on X 2025-07-25 01:52:21 UTC 24.2K followers, 2197 engagements

"Yes. Although with some important distinctions. Also I absolutely share your frustration with microbiome research. Butyrate production is extremely important in the colon for many reasons but one of the top reasons is it supplies XX% of ATP to the colonocytes. Butyrate is mainly produced by saccharolytic bacteria in the colon. They ferment fiber to butyrate acetate and propionate. SCFA is acidic so the production or lack thereof is the primary driver of colonic pH. pH is the driver of what genera live and which ones dominate. In higher pH proteolytic genera are favored and in the instance of"
@gregmushen on X 2025-07-26 15:37:18 UTC 24.2K followers, XXX engagements

"Proteolytic Toxins Surge Protein-fermenting taxa bloom flooding the lumen with ammonia branched-chain fatty acids p-cresol indoles and hydrogen sulfide compounds that are cytotoxic DNA damaging and genotoxic to colonocytes"
@gregmushen on X 2025-07-28 04:13:08 UTC 24.2K followers, XXX engagements

"@creatine_cycle Even worse. One shotted by product (CPO). Leave it to product to always mess things up"
@gregmushen on X 2025-07-17 18:46:53 UTC 24.1K followers, 1992 engagements

"Analyzing Fiber Patterns of the Hadza So the Hadza dont really eat any fiber but they do drink 2-3L of fermented milk. They eat loads of saturated fat yet have very low chronic disease. They dont have much CVD but they do have measured plaque buildup. Fermented milk contains SCFA which is acetate dominant. It is hard to determine an exact fiber equivalent since its all exogenous. 1g of fermentable fiber yields 0.6g of SCFA. 3L of fermented milk would yield about 3.2-4.0g of type X fiber but yields mostly acetate. The remainder of their SCFAs likely come from mucin which would be about 10mmol"
@gregmushen on X 2025-07-27 00:37:41 UTC 24.2K followers, 2670 engagements

"There isnt a single thing you could eat that does more than fiber. And ironically its the one thing you dont technically need to survive"
@gregmushen on X 2025-07-22 15:40:50 UTC 24.2K followers, 44K engagements

"My toxic trait is if I find a rabbit hole I cant help but jump down it"
@gregmushen on X 2025-07-26 16:36:24 UTC 24.2K followers, 3327 engagements

"The more neutral pH/low oxygen environment of the gut makes it perfect for pathogens. With the gut barrier integrity compromised and pathogens like C. rodentium Salmonella and others expand rapidly. This triggers epithelial inflammation and systemic disease"
@gregmushen on X 2025-07-28 04:13:01 UTC 24.2K followers, XXX engagements

"Endogenous cholesterol synthesis is tightly regulated especially in steroidogenic tissue like testes which mostly use locally synthesized cholesterol. Steroid hormone production is gated by LH/FSH signaling not dietary fat intake. No amount of suet will correct the signaling failure. Men with primary hypogonadism cannot produce testosterone. Men with secondary hypogonadism have a signaling failure"
@gregmushen on X 2025-07-20 13:59:21 UTC 24.2K followers, XX engagements

"We werent meant to snack all day. Oh really Hadza men graze constantly while hunting. Berries baobab honey whatever they find. By the time theyre back theyve eaten XX% of their calories. And they have some of the best metabolic health on Earth. They also move a lot"
@gregmushen on X 2025-07-21 22:18:49 UTC 24.2K followers, 31.1K engagements

"@hybridathlete8 What if it is grass fed Himalayan yak butter grazed at XX ft blessed by virgin monks and mixed with coffee and shilajit. Is unlimited OK there"
@gregmushen on X 2025-07-27 14:52:27 UTC 24.2K followers, XXX engagements

"I think what may be difficult to determine is a single cause. It could be a combination of factors that make it difficult to fuse table or associated a single cause. I think the root cause is caloric flux but then describing in broad trends whats caused that is likely multifactorial. - Decreased exercise - Increase reliance on processed food - More processed food means less fermentable fiber - Less fermentable fiber means less SCFA - Less SCFA means less FFAR2 signaling which then means less endogenous GLP-1/PYY increased insulin resistance less hormonal satiation increased adiposity -"
@gregmushen on X 2025-07-25 21:57:41 UTC 24.2K followers, XX engagements

"@nntaleb Couldnt agree more. Theres also a risk of upregulation of glycolic reliance"
@gregmushen on X 2025-07-21 21:42:48 UTC 24.2K followers, 7679 engagements

"@eddycurran @lebosquet Yes. Plant diversity plays a role for sure. What I dont know is how big of a role. Is it just fiber diversity or is it fiber diversity + unique plant compounds I do know the Hadza eat about XXX unique plants a year"
@gregmushen on X 2025-07-27 07:36:41 UTC 24.2K followers, XXX engagements

"@ManjelievskaiaJ Thats so cool. Was it a vintage find"
@gregmushen on X 2025-07-27 19:42:24 UTC 24.2K followers, XX engagements

"Circadian rhythm governs the SCN or master clock. Incredibly important. But its not the only clock we have. We have other peripheral clocks. SCN signals these peripheral clocks but they also respond to independent stimuli such as food. 👇"
@gregmushen on X 2025-07-22 23:41:56 UTC 24.2K followers, 9912 engagements