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![bryan_johnson Avatar](https://lunarcrush.com/gi/w:24/cr:twitter::17468569.png) Bryan Johnson [@bryan_johnson](/creator/twitter/bryan_johnson) on x 626.5K followers
Created: 2025-07-03 19:39:26 UTC

After a year of taking plasmalogens, I stopped.

Plasmalogens are a class of lipids essential to brain and cell membrane health. They decline with age and are linked to neurodegenerative conditions like Alzheimer's.

I tracked mine after a year of supplementation. Before and after results:

-XX% Total ethanolamine plasmalogens (PLEs), this is the most direct marker of the supplement’s intended effect
-XX% EPA- Eethanolamine Plasmalogen
-XX% Total Phosphatidylethanol amines (PEs)
+25% Total Choline Plasmalogens (PLCs)
-XX% DHA-Choline Plasmalogen

Only one subgroup increased. The rest, including the primary targets, dropped. This isn’t a knock on plasmalogens as a concept. Some studies show benefits, especially in early Alzheimer’s. But response depends on baseline levels, absorption, delivery, and genetics. And I had no meaningful upward shift in total levels despite consistent dosing.

Possible issues:
+ Poor absorption?
+ Conversion bottlenecks?
+ Tissue-specific uptake not captured by blood tests?

Plasmalogens had no systemic effect in my case.
I’ll revisit plasmalogens if delivery tech improves or stronger human data emerges. Until then, it's off the stack.

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