# ![@42BWON Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1491977327785709569.png) @42BWON Ecohuro

Ecohuro posts on X about $qure, $ocul, $mbx, sap the most. They currently have [--] followers and [--] posts still getting attention that total [---] engagements in the last [--] hours.

### Engagements: [---] [#](/creator/twitter::1491977327785709569/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1491977327785709569/c:line/m:interactions.svg)

- [--] Week [-----] +230%
- [--] Month [-----] -61%

### Mentions: [--] [#](/creator/twitter::1491977327785709569/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1491977327785709569/c:line/m:posts_active.svg)

- [--] Month [--] -75%

### Followers: [--] [#](/creator/twitter::1491977327785709569/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1491977327785709569/c:line/m:followers.svg)

- [--] Week [--] +5.10%
- [--] Month [--] +7.80%

### CreatorRank: [---------] [#](/creator/twitter::1491977327785709569/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1491977327785709569/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[stocks](/list/stocks)  7.41% [technology brands](/list/technology-brands)  7.41% [finance](/list/finance)  3.7% [premier league](/list/premier-league)  3.7% [champions league](/list/champions-league)  3.7%

**Social topic influence**
[$qure](/topic/$qure) #21, [$ocul](/topic/$ocul) #51, [$mbx](/topic/$mbx) #9, [sap](/topic/sap) 7.41%, [$clpt](/topic/$clpt) 7.41%, [tottenham](/topic/tottenham) 7.41%, [mix](/topic/mix) 3.7%, [bit](/topic/bit) 3.7%, [$rgnx](/topic/$rgnx) 3.7%, [design](/topic/design) 3.7%

**Top accounts mentioned or mentioned by**
[@hawkking1515](/creator/undefined)

**Top assets mentioned**
[uniQure N.V. (QURE)](/topic/$qure) [Ocular Therapeutix, Inc. (OCUL)](/topic/$ocul) [Marblex (MBX)](/topic/$mbx) [Structure Therapeutics Inc. (GPCR)](/topic/$gpcr) [Praxis Precision Medicines, Inc. (PRAX)](/topic/$prax)
### Top Social Posts
Top posts by engagements in the last [--] hours

"As for $QURE Im no longer holding shares. Ive got a mix of April $25 and $45 calls instead. Bit frustrating that its suddenly become such a binary event"  
[X Link](https://x.com/anyuser/status/2021399201339539463)  2026-02-11T01:41Z [--] followers, [---] engagements


"Honestly I think $RGNX shouldve been approved. Its an ultra-rare disease. The FDA did $QURE again. Im tired of their goalpost-moving. I still think it gets approved sometime this year. The stock seems to be reflecting that"  
[X Link](https://x.com/42BWON/status/2021398602644586503)  2026-02-11T01:39Z [--] followers, [----] engagements


"$QURE: Assuming AA FDA could still ask for an RCT(18-mo sham was in the early design so it isnt impossible technically). But in a slow-progressing rare disease like HD Id be surprised if they pushed for it - even the Ph1/2 cut sham to [--] mo"  
[X Link](https://x.com/anyuser/status/2010379158816440615)  2026-01-11T15:51Z [--] followers, [----] engagements


"$qure $ocul $mbx $qttb 🧐"  
[X Link](https://x.com/anyuser/status/2017947620250120474)  2026-02-01T13:06Z [--] followers, [---] engagements


"Relieved again today that $QURE didnt drop any surprise filing(I dont care about AMT-191). The Type-A meeting must already be behind us - and the lack of any negative commentary feels quietly encouraging"  
[X Link](https://x.com/anyuser/status/2019780683841826877)  2026-02-06T14:30Z [--] followers, [----] engagements


"$QURE $GPCR $MBX $PRAX"  
[X Link](https://x.com/anyuser/status/2021399714101592344)  2026-02-11T01:43Z [--] followers, [---] engagements


"My thoughts on $QURE: The FDA hasnt rejected AMT-130s efficacy - the issue is the statistical framework. The agency now states that Phase 1/2 data are unlikely to provide the primary evidence but this comes from a Type B meeting where wording is deliberately non-committal"  
[X Link](https://x.com/42BWON/status/1996957315954790792)  2025-12-05T14:58Z [--] followers, [---] engagements


"$qure AMT-130 delays look inevitable but this isnt a collapse. The FDA isnt dismissing the data -just pushing for stronger justification around the SAP and external controls. An RCT remains extremely unlikely; theyre asking for refinement not new patients"  
[X Link](https://x.com/42BWON/status/1998580996086837411)  2025-12-10T02:30Z [--] followers, [----] engagements


"If the extra analyses are doable a [----] BLA is still realistic. The only real risk is a smaller effect size under stricter methods not lost efficacy. Reality: WWE posing as UFC"  
[X Link](https://x.com/42BWON/status/1998581877406671354)  2025-12-10T02:33Z [--] followers, [---] engagements


"Of course if AMT-130 is a fraud or if VP genuinely has a mental disorder then everything Ive thought about $QURE so far belongs in the bin"  
[X Link](https://x.com/42BWON/status/1998582914297303415)  2025-12-10T02:37Z [--] followers, [---] engagements


"$QURE PMP for AMT-130 is a non-starter. It acts for bespoke therapies. For AMT-130 whilst an RCT is arduous AA remains the correct route. Moreover PMP is little more than an abstract policy statement. Frankly VP taking a bullet might be a more realistic solution"  
[X Link](https://x.com/42BWON/status/1998810834508947742)  2025-12-10T17:43Z [--] followers, [---] engagements


"After watching the interview my takeaway on $QURE: the FDAs pushback centred on AA via external controls and MMs call for broader use of RWE is clearly supportive of AMT-130. $clpt $qure Victor Sung long interview but a lot of nuggets here This was before minutes release interview Take away the p value and look how the [--] progressed. He has never seen a similar cohort show anything like this. That is not the natural history of Huntingtons. Even $clpt $qure Victor Sung long interview but a lot of nuggets here This was before minutes release interview Take away the p value and look how the 12"  
[X Link](https://x.com/42BWON/status/2001563814052208761)  2025-12-18T08:02Z [--] followers, [----] engagements


"$QURE: Initially I suspected the FDAs concerns might relate to the SAP. After Dr Sungs interview it now seems far more likely the pushback was against external controls themselves though the prospects for AA now appear more promising"  
[X Link](https://x.com/42BWON/status/2001566366906941618)  2025-12-18T08:13Z [--] followers, [----] engagements


"@hawkking1515 Dr. Sung stresses that external controls are essential for gene-therapy trials not just for AMT-130. Thats why I think the FDAs pushback was against the use of external controls themselves"  
[X Link](https://x.com/42BWON/status/2001621333814505591)  2025-12-18T11:51Z [--] followers, [---] engagements


"@hawkking1515 He also highlights how robust Enroll-HD is as an external control"  
[X Link](https://x.com/42BWON/status/2001622137417928931)  2025-12-18T11:54Z [--] followers, [---] engagements


"Allowing real world evidence $qure Under President Trumps leadership the FDA: ✅ Just hit a monthly record cell & gene Tx approvals ✅ Hitting ALL drug target date goals ✅ Eliminating animal testing requirements ✅ Reducing decision times (1 yr to months) ✅ Onboarding [----] new scientists ✅ Accelerating Under President Trumps leadership the FDA: ✅ Just hit a monthly record cell & gene Tx approvals ✅ Hitting ALL drug target date goals ✅ Eliminating animal testing requirements ✅ Reducing decision times (1 yr to months) ✅ Onboarding [----] new scientists ✅ Accelerating"  
[X Link](https://x.com/42BWON/status/2002020471274185167)  2025-12-19T14:17Z [--] followers, [---] engagements


"$QURE: Type A scheduled. Dispute request + meeting package accepted for discussion. Guidance targets 14d response / 30d meeting - early Feb at the latest"  
[X Link](https://x.com/42BWON/status/2009612716357656954)  2026-01-09T13:06Z [--] followers, [----] engagements


"If a Type A request gets denied thats a bad sign. The FDA can either reject it outright or grant the meeting but reclassify it as Type C (see screenshot). In $QUREs case though the Type A was granted and its good news"  
[X Link](https://x.com/42BWON/status/2009765132063453686)  2026-01-09T23:12Z [--] followers, [----] engagements


"$REPL playbook (hoping $QURE gets similar): [--] Jul 2025: CRL (FDA letter dated [--] Jul) [--] Sep 2025: Type A scheduled [--] Sep 2025: Type A meeting held (18 Sep: post-meeting update) [--] Oct 2025: BLA resubmission accepted"  
[X Link](https://x.com/42BWON/status/2009897744010543252)  2026-01-10T07:58Z [--] followers, [----] engagements


"Ex-Arsenal CEO Vinai Venkatesham is wrecking Tottenham - while Vinay Prasad is wrecking the FDA. #TottenhamHotspur #FrankOut #ENICOut So Thomas Frank dies not want Conor Gallagher but we are signing him anyway. Why is Thomas Frank still the manager So Thomas Frank dies not want Conor Gallagher but we are signing him anyway. Why is Thomas Frank still the manager"  
[X Link](https://x.com/anyuser/status/2010890517786345839)  2026-01-13T01:43Z [--] followers, [---] engagements


"In Stealths case they managed to secure AA even alongside a CRL. Could something similar be on the cards for $QURE Im honestly not sure - but Im hoping we get a constructive outcome"  
[X Link](https://x.com/anyuser/status/2013634674275557490)  2026-01-20T15:28Z [--] followers, [----] engagements


"My estimate: $qure High-dose n=15: all reach [--] months by [--] Jan [----] (at the latest by early Q2 2026). High-dose n=17: full 36-month maturity between [--] Jul [----] and [--] Mar 2027"  
[X Link](https://x.com/anyuser/status/2011328086323970411)  2026-01-14T06:42Z [--] followers, [----] engagements


"Meanwhile Tottenham Hotspur are collapsing. #VinaiOut #LangeOut #ENICout #FrankOut Michael Carrick beating Man City and Arsenal back to back as a new manager is crazy work Michael Carrick beating Man City and Arsenal back to back as a new manager is crazy work"  
[X Link](https://x.com/anyuser/status/2015760133947814365)  2026-01-26T12:14Z [--] followers, [---] engagements


"$atra s CRL is another FDA U-turn. But its not comparable to $qure. EMA docs attached"  
[X Link](https://x.com/anyuser/status/2010886786558640141)  2026-01-13T01:29Z [--] followers, [----] engagements


"FDA Rare Disease Day Panel [--] looks at how RWD becomes usable RWE at FDA in rare diseases - a timely and relevant discussion for programmes relying on external data. Like $QURE Mark your calendar 📅 FDA's virtual #RareDiseaseDay is February [--] [----]. Together we're prioritizing accelerating medical products for rare diseases and ensuring patient perspectives guide our decisions. Every rare disease matters. Register now: https://t.co/61gBmCImDm https://t.co/LT9YpFGiea Mark your calendar 📅 FDA's virtual #RareDiseaseDay is February [--] [----]. Together we're prioritizing accelerating medical"  
[X Link](https://x.com/anyuser/status/2011451765259125229)  2026-01-14T14:54Z [--] followers, [---] engagements


"Are they in the meeting right now Or did something leak - like pre-meeting written feedback Either way not bad. $QURE $CLPT"  
[X Link](https://x.com/42BWON/status/2014721353891643410)  2026-01-23T15:26Z [--] followers, [---] engagements

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