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[$fbrx](/topic/$fbrx)

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"@ldbioinv But $FBRX dosing is not SC. that's the issue. They are telling us they aren't potent enough by not lowering the dosing see the math in the comments"  
[X Link](https://x.com/plainyogurt21/status/1978952799011434759) [@plainyogurt21](/creator/x/plainyogurt21) 2025-10-16T22:34Z 4878 followers, XXX engagements


"$FBRX $ANAB Based on that PK data and teh IC50 data from the ANAB presentation here's the numbers I get for 3mg/kg Cmax 100ug/ML Ctrough 60ug/ML = 400nM IC90 = 300-1000nm for T cells (CD8 and CD4). This get's close on low dose. And the SC formulation in the Phase X study is up to XXX mg/kg (makes some sense due to volume limits in injections) Tha low dose is borderline the phase 2b. THe subcu dosing doesn't have MAD data on PK nor does it specifify dosing in the phase 2b. We can plug in whatever numbers and thats approximately true. I want to see more PK and PD data from them to be certain"  
[X Link](https://x.com/plainyogurt21/status/1978302993310040077) [@plainyogurt21](/creator/x/plainyogurt21) 2025-10-15T03:32Z 4878 followers, 1584 engagements


"$FBRX kinda cooked based on worse PK binding. (IV dosing)"  
[X Link](https://x.com/plainyogurt21/status/1978201071647396232) [@plainyogurt21](/creator/x/plainyogurt21) 2025-10-14T20:47Z 4878 followers, 4750 engagements