[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Michael Okun [@MichaelOkun](/creator/twitter/MichaelOkun) on x 37.9K followers Created: 2025-07-25 13:00:04 UTC What about using nanoparticles to treat Parkinson's? Could we guide Parkinson’s repair one axon at a time? Could magnetic nanoparticles help repair the Parkinson’s brain? A new study in Advanced Science delivers one of the most creative strategies yet. It is called nano-pulling. By using gentle mechanical forces, scientists directed stem cell derived dopamine neurons to grow in a specific direction. Think of the technique as a potential 'GPS system for brain wiring.' Key Points: - Nano-pulling uses magnetic nanoparticles and external magnetic fields to guide axonal growth of transplanted dopaminergic precursors. - The authors pulled this off using an organoid model that mimicked Parkinson’s. - The authors used co-cultures of substantia nigra and striatum. - The technique enhanced both axon elongation and directional targeting of transplanted neural processes. - Human iPSC-derived dopaminergic neurospheres responded showing increased neurite length, branching, microtubule stability and early synaptic marker expression, all using nano-pulling. My take: Ray and I beleive nanoparticles will play an important role in the future treatment of degenerative diseases like Parkinson's and that is why they are part of the Parkinson's Plan Here are the X points that resonated w/ me the most about this paper. 1- Rebuilding dopamine pathways in the brain is one of the great challenges in Parkinson’s. This study shows we may now have discovered 'a magnet' to help guide that repair. 2- Researchers loaded tiny magnets into stem cells and gently pulled their connections in the appropriate direction. They used external magnetic fields. 3- The cells not only grew longer projections, but they also matured and began forming early connections that could one day restore function. 4- This approach mimics real world brain wiring and might one day soon make stem cell therapies more accurate and effective. 5- While still early and performed in brain slice models, the idea of remote-controlled repair of the Parkinson’s brain is becoming less and less 'science fiction' and more and more reality. #parkinson @ParkinsonDotOrg @FixelInstitute @ScienceMagazine @ScienceAdvances  XXXXX engagements  **Related Topics** [dopamine](/topic/dopamine) [Post Link](https://x.com/MichaelOkun/status/1948729965186306087)
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Michael Okun @MichaelOkun on x 37.9K followers
Created: 2025-07-25 13:00:04 UTC
What about using nanoparticles to treat Parkinson's? Could we guide Parkinson’s repair one axon at a time? Could magnetic nanoparticles help repair the Parkinson’s brain? A new study in Advanced Science delivers one of the most creative strategies yet. It is called nano-pulling. By using gentle mechanical forces, scientists directed stem cell derived dopamine neurons to grow in a specific direction. Think of the technique as a potential 'GPS system for brain wiring.' Key Points:
- Nano-pulling uses magnetic nanoparticles and external magnetic fields to guide axonal growth of transplanted dopaminergic precursors.
- The authors pulled this off using an organoid model that mimicked Parkinson’s.
- The authors used co-cultures of substantia nigra and striatum.
- The technique enhanced both axon elongation and directional targeting of transplanted neural processes.
- Human iPSC-derived dopaminergic neurospheres responded showing increased neurite length, branching, microtubule stability and early synaptic marker expression, all using nano-pulling. My take: Ray and I beleive nanoparticles will play an important role in the future treatment of degenerative diseases like Parkinson's and that is why they are part of the Parkinson's Plan Here are the X points that resonated w/ me the most about this paper. 1- Rebuilding dopamine pathways in the brain is one of the great challenges in Parkinson’s. This study shows we may now have discovered 'a magnet' to help guide that repair. 2- Researchers loaded tiny magnets into stem cells and gently pulled their connections in the appropriate direction. They used external magnetic fields. 3- The cells not only grew longer projections, but they also matured and began forming early connections that could one day restore function. 4- This approach mimics real world brain wiring and might one day soon make stem cell therapies more accurate and effective. 5- While still early and performed in brain slice models, the idea of remote-controlled repair of the Parkinson’s brain is becoming less and less 'science fiction' and more and more reality.
#parkinson @ParkinsonDotOrg @FixelInstitute @ScienceMagazine @ScienceAdvances
XXXXX engagements
Related Topics dopamine