[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  quantumup [@Quantumup1](/creator/twitter/Quantumup1) on x 3534 followers Created: 2025-07-24 12:22:13 UTC H.C. Wainwright reiterated $KRRO Buy-$100 and said, "Yesterday, we hosted Korro Bio in the latest episode of our H.C. Wainwright @ Home series." $BEAM $WVE $PRQR $ARWR $IONS $ALNY H.C, Wainwright added, "We have three key takeaways from our discussion: (1) while DNA-editing approaches and exogenous protein therapies are alternative options to treat AATD, RNA therapy is uniquely positioned, as it is a highly-specific approach that harnesses the body's machinery to restore normal protein levels and address the disease in both the lung and liver; (2) KRRO-110's IV route of administration provides a potency advantage due to instantaneous bioavailability, enabling rapid delivery of ~95% of the drug directly to cytoplasm in hepatocytes within minutes; (3) the goal is to achieve steady-state levels of M-AAT protein equivalent to MZ individuals, with higher levels being a bonus—in a healthy individual, a normal level of M protein is XX (range 20-50); for an MZ individual, typical median total AAT levels stand around XX (range 11-28) with approximately XX% being M-AAT; and for a ZZ individual, typical levels are 4-5 total AAT. As we approach initial Phase 1/2a data sometime this year, we are benchmarking to BEAM-302 and WVE-006. In the wake of this update, we reiterate our Buy rating and 12-month PT of $XXX on KRRO." XXXXX engagements  **Related Topics** [promising](/topic/promising) [ema](/topic/ema) [h2](/topic/h2) [$alny](/topic/$alny) [$prqr](/topic/$prqr) [$wve](/topic/$wve) [$krro](/topic/$krro) [$beam](/topic/$beam) [Post Link](https://x.com/Quantumup1/status/1948358056057639013)
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quantumup @Quantumup1 on x 3534 followers
Created: 2025-07-24 12:22:13 UTC
H.C. Wainwright reiterated $KRRO Buy-$100 and said, "Yesterday, we hosted Korro Bio in the latest episode of our H.C. Wainwright @ Home series." $BEAM $WVE $PRQR $ARWR $IONS $ALNY H.C, Wainwright added, "We have three key takeaways from our discussion: (1) while DNA-editing approaches and exogenous protein therapies are alternative options to treat AATD, RNA therapy is uniquely positioned, as it is a highly-specific approach that harnesses the body's machinery to restore normal protein levels and address the disease in both the lung and liver; (2) KRRO-110's IV route of administration provides a potency advantage due to instantaneous bioavailability, enabling rapid delivery of ~95% of the drug directly to cytoplasm in hepatocytes within minutes; (3) the goal is to achieve steady-state levels of M-AAT protein equivalent to MZ individuals, with higher levels being a bonus—in a healthy individual, a normal level of M protein is XX (range 20-50); for an MZ individual, typical median total AAT levels stand around XX (range 11-28) with approximately XX% being M-AAT; and for a ZZ individual, typical levels are 4-5 total AAT.
As we approach initial Phase 1/2a data sometime this year, we are benchmarking to BEAM-302 and WVE-006. In the wake of this update, we reiterate our Buy rating and 12-month PT of $XXX on KRRO."
XXXXX engagements
Related Topics promising ema h2 $alny $prqr $wve $krro $beam