[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Neuroscience News [@NeuroscienceNew](/creator/twitter/NeuroscienceNew) on x 504.5K followers Created: 2025-07-22 13:58:00 UTC Synaptic Tau and Astrocytes Drive PSP Progression Researchers have uncovered how tau pathology contributes to neurodegeneration in progressive supranuclear palsy (PSP) by targeting synapses. Using human postmortem brain tissue and living brain slice cultures, the study shows tau accumulates within both presynaptic and postsynaptic terminals, supporting the idea that it spreads neuron-to-neuron via synaptic connections. Synapses containing tau were more likely to be lost, and the presence of tau correlated with activation and engulfment by astrocytes. The findings also identified clusterin as a possible mediator of tau’s synaptic binding and spread. In living brain slices, exposure to tau-containing extracts induced synaptic uptake of tau and reactive astrogliosis, mirroring postmortem findings. These results position synaptic tau as a central driver of PSP progression and a compelling target for therapeutic intervention.  XXXXX engagements  **Related Topics** [playstation](/topic/playstation) [tau](/topic/tau) [Post Link](https://x.com/NeuroscienceNew/status/1947657384731504955)
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Neuroscience News @NeuroscienceNew on x 504.5K followers
Created: 2025-07-22 13:58:00 UTC
Synaptic Tau and Astrocytes Drive PSP Progression
Researchers have uncovered how tau pathology contributes to neurodegeneration in progressive supranuclear palsy (PSP) by targeting synapses.
Using human postmortem brain tissue and living brain slice cultures, the study shows tau accumulates within both presynaptic and postsynaptic terminals, supporting the idea that it spreads neuron-to-neuron via synaptic connections.
Synapses containing tau were more likely to be lost, and the presence of tau correlated with activation and engulfment by astrocytes.
The findings also identified clusterin as a possible mediator of tau’s synaptic binding and spread.
In living brain slices, exposure to tau-containing extracts induced synaptic uptake of tau and reactive astrogliosis, mirroring postmortem findings.
These results position synaptic tau as a central driver of PSP progression and a compelling target for therapeutic intervention.
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Related Topics playstation tau