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![Ryansikorski10 Avatar](https://lunarcrush.com/gi/w:24/cr:twitter::1339362210250895361.png) Ryan sikorski [@Ryansikorski10](/creator/twitter/Ryansikorski10) on x 35.5K followers
Created: 2025-07-22 02:39:42 UTC

It sure is CryoSPARC

CryoSPARC: Algorithms for rapid unsupervised cryo-em structure determination

We show that stochastic gradient descent (SGD) and branch-and-bound maximum likelihood optimization algorithms permit the major steps in cryo-EM structure determination to be performed in hours or minutes on an inexpensive desktop computer. Furthermore, SGD with Bayesian marginalization allows ab initio 3D classification, enabling automated analysis and discovery of unexpected structures without bias from a reference map. These algorithms are combined in a user-friendly computer program named cryoSPARC.



CryoSPARC




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[Post Link](https://x.com/Ryansikorski10/status/1947486682204283154)