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 NotTheMoma [@NotTheMoma2](/creator/twitter/NotTheMoma2) on x 1625 followers
Created: 2025-07-20 16:25:56 UTC
#Antibiotics Overuse, is one of many causes of health issues and diseases. That is clear to many of us now.
Can antibiotics increase #galectin-3 levels?
While not a direct or universal effect, antibiotics can lead to increased galectin-3 levels in certain contexts, particularly through their disruption of the gut microbiota and the subsequent impact on #inflammation.
Here's why this connection exists:
Antibiotics and Gut Microbiota #Dysbiosis: Antibiotics can significantly disrupt the balance and diversity of the gut microbiota, a condition known as dysbiosis. This disruption can have various consequences for host health, including alterations in metabolic activities and immune regulation.
Dysbiosis and #Inflammation: Dysbiosis can increase intestinal permeability (also known as "leaky gut"), allowing bacterial products like lipopolysaccharides to enter the bloodstream and trigger inflammation.
#Galectin-3 and #Inflammation: Galectin-3 is a protein that plays a crucial role in inflammation and the immune response, according to the National Institutes of Health (NIH). Elevated galectin-3 levels are associated with increased inflammation and can contribute to the development and progression of various inflammatory conditions.
The Link: When antibiotics induce dysbiosis and subsequent inflammation, the host's immune system may respond by increasing galectin-3 production as part of the inflammatory response. This is particularly relevant in situations where dysbiosis exacerbates inflammatory conditions like inflammatory bowel disease (IBD), where galectin-3 plays a role in the fibrotic process.
Important Considerations:
The extent and type of galectin-3 elevation may vary depending on the specific antibiotic used, the duration of treatment, the individual's gut microbiota composition, and their overall health status.
While some studies suggest that antibiotics can increase galectin-3 levels, more research is needed to fully understand the mechanisms and clinical implications of this association.
The impact of antibiotics on galectin-3 levels should be considered within the broader context of the risks and benefits of antibiotic therapy for bacterial infections.
"Scientific advances made in recent decades have led to an increased recognition of the role of the human gut microbiota in health and disease (Ananthakrishnan et al., 2019). Prior to that, little research had been conducted into the non-pathogenic microorganisms that inhabit the gastrointestinal tract (Guarner, 2012). Because most of these microorganisms cannot be cultured, they remained largely unexplored before the advent of molecular techniques. Ample experimental and clinical evidence now shows that gut microorganisms are required for the optimal functioning of the human body (Guarner, 2015).
In 1885, Louis Pasteur hypothesized that animals raised in sterile conditions would not be able to survive (Pasteur, 1885). Bernard S. Wostmann and his team proved Pasteur’s hypothesis wrong when they developed methods for breeding animals in germ-free conditions (Wostmann, 1981). However, they discovered that germ-free animals required large quantities of nutrient-rich food, yet continued to have stunted growth and development compared with normal animals.
Germ-free animals had smaller hearts, lungs, and livers, lower cardiac output, thinner intestinal walls, reduced gastrointestinal motility, lower serum gamma globulin levels, and atrophied lymph nodes (Wostmann, 1981). Most of these deficiencies can be restored by introducing intestinal microbiota from animals raised under normal conditions. Therefore, while microbial colonization may not be essential for life, it is critical for health (Guarner and Malagelada, 2003; O’Hara and Shanahan, 2006)."
Source:
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NotTheMoma @NotTheMoma2 on x 1625 followers
Created: 2025-07-20 16:25:56 UTC
#Antibiotics Overuse, is one of many causes of health issues and diseases. That is clear to many of us now. Can antibiotics increase #galectin-3 levels? While not a direct or universal effect, antibiotics can lead to increased galectin-3 levels in certain contexts, particularly through their disruption of the gut microbiota and the subsequent impact on #inflammation. Here's why this connection exists:
Antibiotics and Gut Microbiota #Dysbiosis: Antibiotics can significantly disrupt the balance and diversity of the gut microbiota, a condition known as dysbiosis. This disruption can have various consequences for host health, including alterations in metabolic activities and immune regulation.
Dysbiosis and #Inflammation: Dysbiosis can increase intestinal permeability (also known as "leaky gut"), allowing bacterial products like lipopolysaccharides to enter the bloodstream and trigger inflammation.
#Galectin-3 and #Inflammation: Galectin-3 is a protein that plays a crucial role in inflammation and the immune response, according to the National Institutes of Health (NIH). Elevated galectin-3 levels are associated with increased inflammation and can contribute to the development and progression of various inflammatory conditions.
The Link: When antibiotics induce dysbiosis and subsequent inflammation, the host's immune system may respond by increasing galectin-3 production as part of the inflammatory response. This is particularly relevant in situations where dysbiosis exacerbates inflammatory conditions like inflammatory bowel disease (IBD), where galectin-3 plays a role in the fibrotic process.
Important Considerations:
The extent and type of galectin-3 elevation may vary depending on the specific antibiotic used, the duration of treatment, the individual's gut microbiota composition, and their overall health status.
While some studies suggest that antibiotics can increase galectin-3 levels, more research is needed to fully understand the mechanisms and clinical implications of this association.
The impact of antibiotics on galectin-3 levels should be considered within the broader context of the risks and benefits of antibiotic therapy for bacterial infections.
"Scientific advances made in recent decades have led to an increased recognition of the role of the human gut microbiota in health and disease (Ananthakrishnan et al., 2019). Prior to that, little research had been conducted into the non-pathogenic microorganisms that inhabit the gastrointestinal tract (Guarner, 2012). Because most of these microorganisms cannot be cultured, they remained largely unexplored before the advent of molecular techniques. Ample experimental and clinical evidence now shows that gut microorganisms are required for the optimal functioning of the human body (Guarner, 2015).
In 1885, Louis Pasteur hypothesized that animals raised in sterile conditions would not be able to survive (Pasteur, 1885). Bernard S. Wostmann and his team proved Pasteur’s hypothesis wrong when they developed methods for breeding animals in germ-free conditions (Wostmann, 1981). However, they discovered that germ-free animals required large quantities of nutrient-rich food, yet continued to have stunted growth and development compared with normal animals.
Germ-free animals had smaller hearts, lungs, and livers, lower cardiac output, thinner intestinal walls, reduced gastrointestinal motility, lower serum gamma globulin levels, and atrophied lymph nodes (Wostmann, 1981). Most of these deficiencies can be restored by introducing intestinal microbiota from animals raised under normal conditions. Therefore, while microbial colonization may not be essential for life, it is critical for health (Guarner and Malagelada, 2003; O’Hara and Shanahan, 2006)." Source:
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