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![MichaelOkun Avatar](https://lunarcrush.com/gi/w:24/cr:twitter::1563832388.png) Michael Okun [@MichaelOkun](/creator/twitter/MichaelOkun) on x 37.9K followers
Created: 2025-07-19 13:23:50 UTC

Countdown to the MDS Aspen Movement Disorders Course has begun, and we will tease you with cool cases each day until the July 27th launch. Today: Adult-onset opsoclonus-myoclonus which is rare, striking and always demands a thorough workup. This chaotic eye movement and body jerking combination can be the tip of a neurologic iceberg. The differential diagnosis includes paraneoplastic syndromes and think about lung, breast, ovarian cancers and don't forget anti-Ri or anti-Hu antibodies. Always think about neuroblastoma. Also keep in mind autoimmune encephalitis (NMDA receptor, GAD65), post-infectious causes (especially West Nile or Epstein-Barr), toxic-metabolic syndromes, and even neurodegenerative or prion-related processes. And yes, functional can mimic the real deal. Early diagnosis usually leads to better outcomes. See you July 27th-August 1st and if you can't attend in person, follow us for updates during all X days of the meeting.

#NeurologyPearl #OpsoclonusMyoclonus #MovementDisorders #NeuroTwitter
Classic Video from Archives of Neurology 2012. @movedisorder @ParkinsonDotOrg @FixelInstitute

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