[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Stuart Hameroff [@StuartHameroff](/creator/twitter/StuartHameroff) on x 18K followers Created: 2025-07-18 15:39:58 UTC I disagree the roles of amyloid, tau and/or APOE are shown to cause cognitive dysfunction. Tau tangles and release do correlate with cognitive dysfunction because tau is a microtubule associated protein which has nowhere to go when the microtubules fall apart. The problem is just that. The microtubules fall apart. Neurons shrink and retract. Synapses, neuronal volume, memory, cognition and brain volume are lost. Whether memory is in synapses or more likely microtubules, either way it’s lost. How to fix? A promising study of microtubule stabilizer epothilone B seemed to work but the study suddenly stopped for no apparent reason. Microtubules are induced to reassemble by megahertz mechanical oscillations, ultrasound. Safe, painless, effective. It’s not popular in medicine as a therapy in part because it’s not lucrative. Where’s the evidence amyloid causes the cognitive dysfunction? How are the anti-amyloid drugs doing? XXXXX engagements  [Post Link](https://x.com/StuartHameroff/status/1946233494264242495)
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
Stuart Hameroff @StuartHameroff on x 18K followers
Created: 2025-07-18 15:39:58 UTC
I disagree the roles of amyloid, tau and/or APOE are shown to cause cognitive dysfunction. Tau tangles and release do correlate with cognitive dysfunction because tau is a microtubule associated protein which has nowhere to go when the microtubules fall apart. The problem is just that. The microtubules fall apart. Neurons shrink and retract. Synapses, neuronal volume, memory, cognition and brain volume are lost. Whether memory is in synapses or more likely microtubules, either way it’s lost. How to fix? A promising study of microtubule stabilizer epothilone B seemed to work but the study suddenly stopped for no apparent reason.
Microtubules are induced to reassemble by megahertz mechanical oscillations, ultrasound. Safe, painless, effective. It’s not popular in medicine as a therapy in part because it’s not lucrative.
Where’s the evidence amyloid causes the cognitive dysfunction? How are the anti-amyloid drugs doing?
XXXXX engagements
