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![rohanpaul_ai Avatar](https://lunarcrush.com/gi/w:24/cr:twitter::2588345408.png) Rohan Paul [@rohanpaul_ai](/creator/twitter/rohanpaul_ai) on x 73.6K followers
Created: 2025-07-16 07:16:27 UTC

How do memories last when the molecules that form them turn over within days, weeks, or months?

A memory sticks around because two proteins meet in the same tiny spot where two neurons talk. 

Memories can live for decades because PKMζ sticks to KIBRA inside a busy synapse, creating a swap-friendly bond that survives routine protein turnover.

PKMζ is an enzyme that lives inside the synapse, the contact point between neurons.

They act like a bookmark. When one copy of either protein breaks down during normal cell cleanup, a fresh copy plugs straight back into the waiting partner, so the bookmark never goes missing.

The researchers discovered that a persistent bond between two proteins is associated with the strengthening of synapses, which are the connections between neurons. 

Synaptic strengthening is thought to be fundamental to memory formation. 

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wired .com/story/the-molecular-bond-that-helps-secure-your-memories/

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rohanpaul_ai Avatar Rohan Paul @rohanpaul_ai on x 73.6K followers Created: 2025-07-16 07:16:27 UTC

How do memories last when the molecules that form them turn over within days, weeks, or months?

A memory sticks around because two proteins meet in the same tiny spot where two neurons talk.

Memories can live for decades because PKMζ sticks to KIBRA inside a busy synapse, creating a swap-friendly bond that survives routine protein turnover.

PKMζ is an enzyme that lives inside the synapse, the contact point between neurons.

They act like a bookmark. When one copy of either protein breaks down during normal cell cleanup, a fresh copy plugs straight back into the waiting partner, so the bookmark never goes missing.

The researchers discovered that a persistent bond between two proteins is associated with the strengthening of synapses, which are the connections between neurons.

Synaptic strengthening is thought to be fundamental to memory formation.


wired .com/story/the-molecular-bond-that-helps-secure-your-memories/

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