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![NeuroscienceNew Avatar](https://lunarcrush.com/gi/w:24/cr:twitter::32302688.png) Neuroscience News [@NeuroscienceNew](/creator/twitter/NeuroscienceNew) on x 504.3K followers
Created: 2025-07-13 19:55:24 UTC

Gene Key to MS Immune Regulation Discovered

A new study has identified the gene Egr-1 as a key regulator of immune balance in multiple sclerosis (MS), offering a potential new therapeutic target.

Researchers found that Egr-1 boosts the activity of regulatory T cells (Tregs), which help suppress harmful immune responses.

Mice lacking Egr-1 showed worse disease progression, with fewer Tregs and more inflammatory cells.

Importantly, the team demonstrated that Egr-1 directly activates the Foxp3 gene, essential for Treg development, via the TGF-β signaling pathway.

They also showed that a natural compound, calycosin, acts as an Egr-1 agonist, improving outcomes in MS model mice.

These findings suggest that enhancing Egr-1 activity could help restore immune balance in autoimmune diseases like MS.

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