[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Derya Unutmaz, MD [@DeryaTR_](/creator/twitter/DeryaTR_) on x 316.6K followers Created: 2025-07-12 05:00:03 UTC You are a world‐leading expert in HIV, immunology and therapeutic development. Despite four decades of research, no definitive cure or broadly protective vaccine for HIV has been achieved. Drawing on the latest insights from structural biology, gene editing, immuno-engineering and systems medicine, think deeply and creatively about how to break this deadlock. Develop and describe ten distinct, high‐impact approaches, ranging from novel immunogens and delivery platforms to cell- and gene-based therapies, that could realistically lead to either a functional cure or an effective vaccine. For each approach, include: X. A concise name or concept title X. Underlying biological rationale X. Key technological or methodological innovation X. Anticipated mechanism of action X. Major technical or safety challenges and how to address them X. A rough timeline or next‐step experiment to validate feasibility Be bold, interdisciplinary, and specific. Your goal is to map out ten clear paths that, if pursued rigorously, could finally solve the HIV cure/vaccine challenge. XXXXXXX engagements  **Related Topics** [has been](/topic/has-been) [Post Link](https://x.com/DeryaTR_/status/1943898123513852237)
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
Derya Unutmaz, MD @DeryaTR_ on x 316.6K followers
Created: 2025-07-12 05:00:03 UTC
You are a world‐leading expert in HIV, immunology and therapeutic development. Despite four decades of research, no definitive cure or broadly protective vaccine for HIV has been achieved. Drawing on the latest insights from structural biology, gene editing, immuno-engineering and systems medicine, think deeply and creatively about how to break this deadlock. Develop and describe ten distinct, high‐impact approaches, ranging from novel immunogens and delivery platforms to cell- and gene-based therapies, that could realistically lead to either a functional cure or an effective vaccine. For each approach, include:
X. A concise name or concept title
X. Underlying biological rationale
X. Key technological or methodological innovation
X. Anticipated mechanism of action
X. Major technical or safety challenges and how to address them
X. A rough timeline or next‐step experiment to validate feasibility
Be bold, interdisciplinary, and specific. Your goal is to map out ten clear paths that, if pursued rigorously, could finally solve the HIV cure/vaccine challenge.
XXXXXXX engagements
Related Topics has been