[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]  Neuroscience News [@NeuroscienceNew](/creator/twitter/NeuroscienceNew) on x 504.2K followers Created: 2025-07-09 19:53:46 UTC Genes and Brain Wiring Team Up in Alzheimer’s Spread A new study has revealed how genes and brain networks interact to shape the spread of tau protein in Alzheimer’s disease. Researchers combined brain scans, gene expression maps, and a sophisticated mathematical model to identify genetic factors that either amplify vulnerability or enhance resilience in specific brain regions. They found four distinct gene types: some promoting tau buildup along brain connections, others independently, and others conferring protection through immune responses or cleanup mechanisms. The findings challenge the traditional view that tau spreads randomly, showing instead that it follows the brain’s wiring and is modulated by local gene expression. These insights open new paths for understanding why some brain areas deteriorate while others remain resilient. Ultimately, the work could help identify gene-based targets for future Alzheimer’s therapies.  XXXXX engagements  **Related Topics** [tau](/topic/tau) [networks](/topic/networks) [Post Link](https://x.com/NeuroscienceNew/status/1943035870673510690)
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Neuroscience News @NeuroscienceNew on x 504.2K followers
Created: 2025-07-09 19:53:46 UTC
Genes and Brain Wiring Team Up in Alzheimer’s Spread
A new study has revealed how genes and brain networks interact to shape the spread of tau protein in Alzheimer’s disease.
Researchers combined brain scans, gene expression maps, and a sophisticated mathematical model to identify genetic factors that either amplify vulnerability or enhance resilience in specific brain regions.
They found four distinct gene types: some promoting tau buildup along brain connections, others independently, and others conferring protection through immune responses or cleanup mechanisms.
The findings challenge the traditional view that tau spreads randomly, showing instead that it follows the brain’s wiring and is modulated by local gene expression.
These insights open new paths for understanding why some brain areas deteriorate while others remain resilient.
Ultimately, the work could help identify gene-based targets for future Alzheimer’s therapies.
XXXXX engagements
