# ![@totalsynthesis Avatar](https://lunarcrush.com/gi/w:26/cr:youtube::UCbT-5vQ6alxQVgy8My059OQ.png) @totalsynthesis Total Synthesis

Total Synthesis posts on YouTube about products, science, how to, joe the most. They currently have [------] followers and [--] posts still getting attention that total [-----] engagements in the last [--] hours.

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### Followers: [------] [#](/creator/youtube::UCbT-5vQ6alxQVgy8My059OQ/followers)
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### Social Influence

**Social category influence**
[countries](/list/countries)  [stocks](/list/stocks)  [musicians](/list/musicians)  [technology brands](/list/technology-brands)  [cryptocurrencies](/list/cryptocurrencies)  [travel destinations](/list/travel-destinations) 

**Social topic influence**
[products](/topic/products), [science](/topic/science), [how to](/topic/how-to), [joe](/topic/joe), [joe rogan](/topic/joe-rogan), [brain](/topic/brain), [history](/topic/history), [safe](/topic/safe), [carbon](/topic/carbon), [approved](/topic/approved)

**Top assets mentioned**
[Uber Technologies, Inc. (UBER)](/topic/$uber) [Eli Lilly and Company (LLY)](/topic/eli-lilly) [Novartis AG (NVS)](/topic/novartis)
### Top Social Posts
Top posts by engagements in the last [--] hours

"Epic First Cocaine Synthesis in [--] Steps (Educational) Cocaine is intertwined with the fabric of society and science in more profound ways than most realize. Join us to hear about 1) current data on cocaine use 2) history and discovery of cocaine 3) the first landmark total synthesis of cocaine by Richard Wilsttter and 4) other evolutions of (bio)chemical synthesis (Robinson Noyori). Note that we do not cover biological origins isolation or other aspects in detail. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=7xoPNlV3_LA)  2024-03-23T15:05Z 63.7K followers, 166.2K engagements


"LSD Synthesis in [--] Steps (Educational) Lysergic acid organic chemistry reaction mechanisms This video does not explain or suggest how to make drugs and is purely educational and theoretical. A team of chemists recently reported a synthesis of lysergic acid the precursor of the psychoactive drug LSD in only [--] laboratory steps. In this video we will learn why LSD-like scaffolds are of interest to modern drug discovery and look into the chemistry of this short but sweet synthesis. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=ieFD-1iHpBw)  2023-02-17T16:15Z 63.7K followers, 725.2K engagements


"Total Synthesis of Lysergic Acid (LSD Precursor): Retrosynthesis & Mechanisms (Hofmann Woodward) Let's walk through the history of lysergic acid - a LSD precursor - and dive into the organic chemistry behind 1) its first total synthesis and 2) a modern more advanced approach. NOTE: This was my first video EVER so my the audio and visual quality has improved since* Feel free to check out my newer videos :) https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters"  
[YouTube Link](https://youtube.com/watch?v=40wbHWw9mvU)  2018-06-12T15:18Z 63.7K followers, 320.4K engagements


"MDMA synthesis in [--] steps & how it could help PTSD therapy (educational) Chemistry & Science 🧠 Did you know that MDMA-assisted therapy was recently suggested to be highly effective for people with severe PTSD In this video we will break down MDMA's history and discovery synthetic approaches from the literature - including a kilo-scale process route - and clinical data from a Phase [--] study investigating MDMA's therapeutic benefit. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to"  
[YouTube Link](https://youtube.com/watch?v=onaKmEUtNbc)  2023-03-26T15:36Z 63.7K followers, 270.3K engagements


"Chemists made N6. How energetic is it Hexanitrogen In this educational video we review a breakthrough in nitrogen chemistry: the preparation of N6 We cover allotropes and uber-sensitive nitrogen compounds the achievement of making hexanitrogen and theoretical commentary on potential applications. ➡ Check out "Periodic Tales - The Freshman Mole" (+ preview pages) https://total-synthesis.com/freshman-mole/ 🚀 Thanks to all channel supporters https://www.patreon.com/totalsynthesis 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news"  
[YouTube Link](https://youtube.com/watch?v=r23G4cMQr3Y)  2026-01-17T15:00Z 63.7K followers, 190K engagements


"Chemists Flip [--] Atoms in LSD to Make it a Better Medicine (Educational Science Video) 🧠 To exercise your brain and improve your neuroplasticity go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram"  
[YouTube Link](https://youtube.com/watch?v=MNzWahUqTxA)  2025-05-30T14:43Z 63.7K followers, 23.9K engagements


"How SN2 Reactions Look Like (Animation) Organic Chemistry Substitution Mechanism 👀 Let's take a look at SN2 reactions geometries and molecular visualizations. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news https://total-synthesis.com 00:00 Classic SN2 reaction (Williamson ether synthesis) 02:14 Sterics in SN2"  
[YouTube Link](https://youtube.com/watch?v=MYszpIgJ_mM)  2024-01-14T16:03Z 63.7K followers, [----] engagements


"Explosive & Strained Molecular Cubes: Azahomocubane: Organic Chemistry Cubane Synthesis & Mechanisms 💣 In this video we dissect the synthesis and properties of azahomocubane a recently synthesized homocubane 'azalogue'. Is it as unstable or explosive as the malevolent octanitrocubane Watch to find out Please drop a like and comment to support the video's visibility activate notifications and subscribe to the channel so you do not miss future videos https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=24SpQTYRh38)  2023-03-10T15:59Z 63.7K followers, 13.7K engagements


"Psilocybin Synthesis in [--] Steps & How Magic Mushrooms Rewire Brain Networks (Psychedelic Science) 🍄 Psilocybin is emerging as a promising "therapeutic psychedelic" across various different conditions and diseases. What is the buzz about and how does psilocybin work In this video we dive into psilocybin's rich history chemical structure and biochemical mechanism of action. This includes striking effects like dendritogenesis and synaptic rewiring in mice. We will review a large scale synthesis of psilocybin delivering an impressive [---] kg of cGMP material for clinical supply - this works using"  
[YouTube Link](https://youtube.com/watch?v=vH-TOn9d1pE)  2023-05-14T13:00Z 63.7K followers, 465.2K engagements


"How Chemists Make Carbon 2+ (Octet Rule: Violated) Organic Chemistry & Synthesis Yep you're looking at a carbon with four valence electrons. How can such an unfavorable species be synthesized how is it stabilized and how does it behave Watch this video to learn exotic chemical reactions and unique properties and geometries - which you likely have never seen before https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters"  
[YouTube Link](https://youtube.com/watch?v=0r-8sRgnnhI)  2024-02-04T15:37Z 63.7K followers, 10.9K engagements


"When One Nitrogen Atom Saves Your Life . or Pancreas ➡ Check out the preview & links for "Periodic Tales - The Freshman Mole" https://total-synthesis.com/freshman-mole/ In this video we discuss the biology and medicinal chemistry behind the optimization of cyclophilin D inhibitors - a class of molecules that might be able to make cells more resilient and protect them from stress and ultimately death 🚀 Thanks to all channel supporters https://www.patreon.com/totalsynthesis 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news"  
[YouTube Link](https://youtube.com/watch?v=B-WlNa3l8fw)  2025-12-19T16:27Z 63.7K followers, [----] engagements


"This Total Synthesis will help you Master Organic Chemistry Natural products are not created equal: some become breast cancer drugs; others only manage to make lettuce seedlings slightly uncomfortable. What about Punctaporonin U It lacks any biological activity but it makes this up with an impressive cage-like pentacyclic structure featuring eight contiguous stereocenters. More than enough reason for synthetic chemists to try to make it in the lab In this video we discuss the first enantioselective synthesis of this natural product reported by Zhu and co-workers. Doing so we'll review our"  
[YouTube Link](https://youtube.com/watch?v=BFl9wnIDec0)  2025-11-08T13:15Z 63.7K followers, 17K engagements


"This Drug Synthesis is Literally Breathtaking Medicinal Chemistry & Organic Synthesis This molecule might look like any other 'flat drug' - but there's a mystery hidden behind its synthesis Coupled with the fact that it showed promise in asthma due to its novel mechanism you could say that it's breath-taking (actually more like breath-giving but I figured no one will understand this). Watch this video to learn more about organic synthesis drug development and more https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=DGJ0UaZuSWo)  2024-05-04T14:37Z 63.7K followers, 57.8K engagements


"Why MDMA did NOT get FDA approval 🤔 Some call it surprising others saw it coming: MDMA-assisted therapy in PTSD will not be approved in the near-term future as the US FDA requests additional Phase [--] data to show more conclusive safety and evidence benefits. What might be reasons for the rejection despite the significant hopes In this video we will look at different public opinions and case reports. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters"  
[YouTube Link](https://youtube.com/watch?v=Qdaf77P9Efo)  2024-08-11T17:26Z 63.7K followers, 21.4K engagements


"Worlds Most EXPENSIVE Medicines: Greedy or Fair What Makes them Special (Gene Therapy Chemistry) 🤑 Imagine a single dose of medicine priced at $3.5 MILLION. Since the approval of the gene therapy Hemgenix this is a reality. How can this be fair Stay tuned to better understand the costs and risks of drug development learn about the world's most expensive gene therapy and small molecule and learn some new things about science. Please drop a like and comment to support the video's visibility activate notifications and subscribe to the channel so you do not miss future videos"  
[YouTube Link](https://youtube.com/watch?v=lIz0sbZ1P6A)  2023-07-21T16:08Z 63.7K followers, 23.2K engagements


"How does Chemotherapy work From Chemical Weapons to Cancer Treatment Why do we have cancer chemotherapies and how do they work Watch this video to learn about more about history science and random facts If you find this interesting make sure you check out our prior video on the birth of drug development (https://youtu.be/geOmYSkdSuQ). https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on"  
[YouTube Link](https://youtube.com/watch?v=nf9SaGAsd4c)  2025-10-26T14:20Z 63.7K followers, [----] engagements


"Treating Brain Cancer with a $50 Antidepressant Drug Repurposing in Glioblastoma Imagine finding the Holy Grail on a dusty shelf. This video delves into drug repurposing a promising approach that saves time and cost by using approved medications for new diseases. We explore temozolomide our main weapon against the aggressive brain cancer glioblastoma - its synthesis mechanism and why it just barely extends survival. New research shows antidepressants like vortioxetine might have value as add-on therapies. Could this unexpected duo be the next step or even cure in the fight against"  
[YouTube Link](https://youtube.com/watch?v=qwLjV_A3hNg)  2024-10-07T15:02Z 63.7K followers, 20.9K engagements


"The Best Ibogaine Synthesis Yet Or Not Really (Educational Organic Chemistry) The psychoactive natural product ibogaine enjoys attention of professional and also less professional communities (😶) given its promising effects against substance use or mood disorders among other indications. Recent research led by Prof. Olson achieved the shortest and highest yielding chemical synthesis of ibogaine to date. Many articles on this imply that the total synthesis of ibogaine is an achievement by itself ("psychedelic ibogaine can now be produced without rare plants") but clever viewers will know that"  
[YouTube Link](https://youtube.com/watch?v=xQT2PJ-H6Yc)  2025-02-23T15:37Z 63.7K followers, 11.2K engagements


"How Do SN2 Reactions Work (Animation) Organic Chemistry Substitution Mechanism #shorts #short 👀 Let's take a "more visual look" (is that a pleonasm) at SN2 reactions geometries and molecular structures. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news https://total-synthesis.com Some recommended books on organic synthesis: - Clayden Greeves Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt Warren;"  
[YouTube Link](https://youtube.com/watch?v=L_VBzuLIg2s)  2024-01-14T20:46Z 63.7K followers, 17.8K engagements


"Cancer Breakthrough Scientists find unexpected brain cancer drug #science #medicine #chemistry Imagine finding the Holy Grail on a dusty shelf. This video delves into drug repurposing a promising approach that saves time and cost by using approved medications for new diseases. We explore temozolomide our main weapon against the aggressive brain cancer glioblastoma - its synthesis mechanism and why it just barely extends survival. New research shows antidepressants like vortioxetine might have value as add-on therapies. Could this unexpected duo be the next step or even cure in the fight"  
[YouTube Link](https://youtube.com/watch?v=zHVSaL5LcSg)  2024-10-07T18:28Z 63.7K followers, [----] engagements


"How one of Nature's Most Complex Molecules Is Made: Synthesis of Taxol's "Complicated Cousin" Taxol - a commonly used anticancer drug - is part of a broader family of taxane natural products - which includes Canaxpropellane Taxol's "complicated cousin". We will explore some of the related - and unrelated :) - history biochemistry and chemistry facts and trivia. Even if you are not deeply engaged with total synthesis I am confident that this video will enrich your understanding of natural sciences. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry"  
[YouTube Link](https://youtube.com/watch?v=3B0jzfmJz70)  2021-08-24T19:01Z 63.7K followers, 34.4K engagements


"Legal High from Moss better than Medical Cannabis THC & CBD Biology Chemistry & Synthesis Let's discuss the history biochemistry pharmacology and total synthesis of cannabinoids a class of interesting and useful natural products. We explore recent research to exemplify the potential of cannabinoids in medicine. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random"  
[YouTube Link](https://youtube.com/watch?v=H7nuv74GHu4)  2019-01-03T20:24Z 57.5K followers, 42.9K engagements


"Why COAL MINES could deliver new CANCER MEDICINES Chemistry Total Synthesis #Short #Short Check out my channel for interesting videos on biology and science - always with a connection to synthetic organic chemistry. Scientists have discovered bacteria and fungi that are fighting each other in abandoned contaminated coalmines during which they produce promising anti-cancer and antibiotic natural products that could save thousands of lives. This is a striking example of how much we can learn from organisms that live in extreme conditions. Medicine could learn and gain a lot from these molecules"  
[YouTube Link](https://youtube.com/watch?v=M3pw8XssvkQ)  2022-04-08T17:01Z 63.7K followers, [----] engagements


"Chemists Just Made Impossible Molecules. Really (Bredts rule) 🫠 NOT AGAIN Chemistry rules seem to be made to be broken. Bredt's rule is typically understood to prohibit the existence of double bonds at bridgehead positions. New research from the Garg lab offers practical ways to synthesize such "impossible" species but how novel and ground-breaking is this From Julius Bredt's studies on camphor in the 19th century to modern-day research pushing the limits of "impossible" molecules we will explore how chemists have defied the odds to create anti-Bredt olefins. Whether you're a synthesis"  
[YouTube Link](https://youtube.com/watch?v=Mq6ACtLcWdQ)  2024-12-13T16:01Z 63.7K followers, 25.5K engagements


"This New Chemical is Fascinating But How Does it React Diazo-Ylide Hybrid 🤯 This a REALLY strange but surprisingly stable and versatile chemical. We all know carbenes but have you ever heard of carbones This reagent reactivities you might already know from the Wittig reaction Seyferth-Gilbert homologation and diazo chemistry. In this video we explore its synthesis properties with intriguing resonance structures and reactions. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all"  
[YouTube Link](https://youtube.com/watch?v=Oqd71V8c3Ac)  2024-08-03T14:59Z 63.7K followers, 15.7K engagements


"Machines Can Now Discover Drugs. Are They Better 🤖 To learn how AI really works go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. Unless youve been living under a rock youll agree that AI is being explored used and abused across industries. This includes natural sciences and pharmaceutical research and development where weve seen frenzies of investments and bold projections. But are drugs discovered or otherwise touched by AI actually better In this video"  
[YouTube Link](https://youtube.com/watch?v=QfTtfL2k3AM)  2025-07-20T14:55Z 63.7K followers, [----] engagements


"How Chemists Synthesize "Mad Honey" Toxins (Science & Organic Chemistry) #science #chemistry 🐝 Mad honey is a natural but neurotoxic substance created when bees happen to collect nectar from certain poisonous plants. From ancient military mishaps to cutting-edge drug development we connect history biology and chemistry in this educational video. The second part explains the total synthesis of kalmanol (a rare cousin of grayanotoxin the primary toxin in mad honey) which is more geared towards chemistry students and synthesis nerds. Thank you for your interest"  
[YouTube Link](https://youtube.com/watch?v=Uvig4efjnTg)  2025-01-26T16:00Z 63.7K followers, [----] engagements


"Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction Psychedelic Science This video explains biochemistry organic synthesis and physiological effects - including pre-clinical research on mice/ rats - of ibogaine ibogamine and other related molecules which might prove useful as the need for effective therapies against substance use disorder and other addiction disorders increase. If you like the video consider commenting sharing it with a fellow nerd and subscribing to the channel so you do not miss future videos"  
[YouTube Link](https://youtube.com/watch?v=W3xuJ0TQQ-w)  2023-09-17T15:01Z 63.7K followers, 34.7K engagements


"This Chemical Reaction Is Literal Magic & You Never Heard Of It ⚛ If you need to brush up on quantum mechanics or other topics in science math or programming go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. If there is a chemistry cheat code this reaction might be it. In this video we explain the theoretical grounds and practical applications of dyotropic reactions. In these rearrangements two sigma bonds migrate simultaneously or "swap places". This first"  
[YouTube Link](https://youtube.com/watch?v=W8Z281blvFo)  2025-04-19T14:28Z 63.7K followers, 32.9K engagements


"Carbon Just Did WHAT One Electron Carbon-Carbon Bond (Organic Chemistry) 🤔 OH BOY will Organic Chemistry get even harder for struggling students In this video we explain the recent discovery of a one-electron carbon-carbon sigma bond. Although some assume this is completely unprecedented there is long history of one-electron bonds in general. This video explains the context of this scientific advance what's really new about it and the detailed chemistry behind it. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=gi6gvkvUbLQ)  2024-10-18T14:35Z 63.7K followers, 45.3K engagements


"This Surprising Synthesis Will Teach You Organic Chemistry (Rauvomine B) 🤯 "Protecting groups protect" - Makes sense right Well until it doesn't. In this video we will learn more about this and explore interesting organic chemistry reactions by studying the total synthesis of rauvomine B (note: not peer reviewed yet so it could be all made up). https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me"  
[YouTube Link](https://youtube.com/watch?v=igTCAgC1gfg)  2024-07-06T14:06Z 63.7K followers, 19.4K engagements


"MAD HONEY Toxin Synthesis (Educational): Science & Chemistry of Grayanotoxin & Kalmanol 🐝 Mad honey is a natural but neurotoxic substance created when bees happen to collect nectar from certain poisonous plants. From ancient military mishaps to cutting-edge drug development we connect history biology and chemistry in this educational video. The second part explains the total synthesis of kalmanol (a rare cousin of grayanotoxin the primary toxin in mad honey) which is more geared towards chemistry students and synthesis nerds. Thank you for your interest"  
[YouTube Link](https://youtube.com/watch?v=pON-gNDtATc)  2025-01-17T16:56Z 63.7K followers, 18.7K engagements


"Cursed Carbon with [--] Bonds Chemistry of the Hexamethylbenzene Dication 🤔 Can carbon go beyond the octet rule You might know the situation for CH5+ but what about the extremely cursed hexamethylbenzene dication In this video we explain the context synthesis and bonding situation of this apparently hypervalent carbon. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on"  
[YouTube Link](https://youtube.com/watch?v=pfWvvGRYTIc)  2024-10-30T16:04Z 63.7K followers, 19.3K engagements


"Chemical Synthesis of Ibogaine in [--] Steps #science #podcast #biology Full video linked The psychoactive natural product ibogaine enjoys attention of professional and also less professional communities (😶) given its promising effects against substance use or mood disorders among other indications. Recent research led by Prof. Olson achieved the shortest and highest yielding chemical synthesis of ibogaine to date. Many articles on this imply that the total synthesis of ibogaine is an achievement by itself ("psychedelic ibogaine can now be produced without rare plants") but clever viewers will"  
[YouTube Link](https://youtube.com/watch?v=q-ezHUsQRss)  2025-02-28T15:30Z 63.7K followers, [----] engagements


"How "Heavy Hydrogen" makes Drugs work: Deuterium in Pharmaceuticals Organic Chemistry & Synthesis Organic chemistry does not only use abundant forms of atoms but also rare isotopes such as deuterium - the heavy form of hydrogen. Addition of "the D" can completely transform a molecule's reactivity and pharmacokinetic properties. Watch this to find out more about the physical chemistry biochemistry and organic synthesis associated with Deuterium and more specifically the discovery route and large-scale process behind the second deuterated drug to be approved by the US FDA deucravacitinib"  
[YouTube Link](https://youtube.com/watch?v=ztAcL43kCl0)  2023-01-01T17:08Z 63.7K followers, 33.5K engagements


"Chemists made N6. How energetic is it Hexanitrogen In this educational video we review a breakthrough in nitrogen chemistry: the preparation of N6 We cover allotropes and uber-sensitive nitrogen compounds the achievement of making hexanitrogen and theoretical commentary on potential applications. ➡ Check out "Periodic Tales - The Freshman Mole" (+ preview pages) https://total-synthesis.com/freshman-mole/ 🚀 Thanks to all channel supporters https://www.patreon.com/totalsynthesis 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news"  
[YouTube Link](https://youtube.com/watch?v=r23G4cMQr3Y)  2026-01-17T15:00Z 63.7K followers, 190K engagements


"When One Nitrogen Atom Saves Your Life . or Pancreas ➡ Check out the preview & links for "Periodic Tales - The Freshman Mole" https://total-synthesis.com/freshman-mole/ In this video we discuss the biology and medicinal chemistry behind the optimization of cyclophilin D inhibitors - a class of molecules that might be able to make cells more resilient and protect them from stress and ultimately death 🚀 Thanks to all channel supporters https://www.patreon.com/totalsynthesis 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news"  
[YouTube Link](https://youtube.com/watch?v=B-WlNa3l8fw)  2025-12-19T16:27Z 63.7K followers, [----] engagements


"This Total Synthesis will help you Master Organic Chemistry Natural products are not created equal: some become breast cancer drugs; others only manage to make lettuce seedlings slightly uncomfortable. What about Punctaporonin U It lacks any biological activity but it makes this up with an impressive cage-like pentacyclic structure featuring eight contiguous stereocenters. More than enough reason for synthetic chemists to try to make it in the lab In this video we discuss the first enantioselective synthesis of this natural product reported by Zhu and co-workers. Doing so we'll review our"  
[YouTube Link](https://youtube.com/watch?v=BFl9wnIDec0)  2025-11-08T13:15Z 63.7K followers, 17K engagements


"How does Chemotherapy work From Chemical Weapons to Cancer Treatment Why do we have cancer chemotherapies and how do they work Watch this video to learn about more about history science and random facts If you find this interesting make sure you check out our prior video on the birth of drug development (https://youtu.be/geOmYSkdSuQ). https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on"  
[YouTube Link](https://youtube.com/watch?v=nf9SaGAsd4c)  2025-10-26T14:20Z 63.7K followers, [----] engagements


"Machines Can Now Discover Drugs. Are They Better 🤖 To learn how AI really works go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. Unless youve been living under a rock youll agree that AI is being explored used and abused across industries. This includes natural sciences and pharmaceutical research and development where weve seen frenzies of investments and bold projections. But are drugs discovered or otherwise touched by AI actually better In this video"  
[YouTube Link](https://youtube.com/watch?v=QfTtfL2k3AM)  2025-07-20T14:55Z 63.7K followers, [----] engagements


"Chemists Flip [--] Atoms in LSD to Make it a Better Medicine (Educational Science Video) 🧠 To exercise your brain and improve your neuroplasticity go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram"  
[YouTube Link](https://youtube.com/watch?v=MNzWahUqTxA)  2025-05-30T14:43Z 63.7K followers, 23.9K engagements


"This Chemical Reaction Is Literal Magic & You Never Heard Of It ⚛ If you need to brush up on quantum mechanics or other topics in science math or programming go to https://brilliant.org/TotalSynthesis/ to explore Brilliant for free for a full [--] days. Youll also get 20% off an annual premium subscription. This video was sponsored by Brilliant. If there is a chemistry cheat code this reaction might be it. In this video we explain the theoretical grounds and practical applications of dyotropic reactions. In these rearrangements two sigma bonds migrate simultaneously or "swap places". This first"  
[YouTube Link](https://youtube.com/watch?v=W8Z281blvFo)  2025-04-19T14:28Z 63.7K followers, 32.9K engagements


"Chemical Synthesis of Ibogaine in [--] Steps #science #podcast #biology Full video linked The psychoactive natural product ibogaine enjoys attention of professional and also less professional communities (😶) given its promising effects against substance use or mood disorders among other indications. Recent research led by Prof. Olson achieved the shortest and highest yielding chemical synthesis of ibogaine to date. Many articles on this imply that the total synthesis of ibogaine is an achievement by itself ("psychedelic ibogaine can now be produced without rare plants") but clever viewers will"  
[YouTube Link](https://youtube.com/watch?v=q-ezHUsQRss)  2025-02-28T15:30Z 63.7K followers, [----] engagements


"The Best Ibogaine Synthesis Yet Or Not Really (Educational Organic Chemistry) The psychoactive natural product ibogaine enjoys attention of professional and also less professional communities (😶) given its promising effects against substance use or mood disorders among other indications. Recent research led by Prof. Olson achieved the shortest and highest yielding chemical synthesis of ibogaine to date. Many articles on this imply that the total synthesis of ibogaine is an achievement by itself ("psychedelic ibogaine can now be produced without rare plants") but clever viewers will know that"  
[YouTube Link](https://youtube.com/watch?v=xQT2PJ-H6Yc)  2025-02-23T15:37Z 63.7K followers, 11.2K engagements


"How Chemists Synthesize "Mad Honey" Toxins (Science & Organic Chemistry) #science #chemistry 🐝 Mad honey is a natural but neurotoxic substance created when bees happen to collect nectar from certain poisonous plants. From ancient military mishaps to cutting-edge drug development we connect history biology and chemistry in this educational video. The second part explains the total synthesis of kalmanol (a rare cousin of grayanotoxin the primary toxin in mad honey) which is more geared towards chemistry students and synthesis nerds. Thank you for your interest"  
[YouTube Link](https://youtube.com/watch?v=Uvig4efjnTg)  2025-01-26T16:00Z 63.7K followers, [----] engagements


"MAD HONEY Toxin Synthesis (Educational): Science & Chemistry of Grayanotoxin & Kalmanol 🐝 Mad honey is a natural but neurotoxic substance created when bees happen to collect nectar from certain poisonous plants. From ancient military mishaps to cutting-edge drug development we connect history biology and chemistry in this educational video. The second part explains the total synthesis of kalmanol (a rare cousin of grayanotoxin the primary toxin in mad honey) which is more geared towards chemistry students and synthesis nerds. Thank you for your interest"  
[YouTube Link](https://youtube.com/watch?v=pON-gNDtATc)  2025-01-17T16:56Z 63.7K followers, 18.7K engagements


"Chemists Just Made Impossible Molecules. Really (Bredts rule) 🫠 NOT AGAIN Chemistry rules seem to be made to be broken. Bredt's rule is typically understood to prohibit the existence of double bonds at bridgehead positions. New research from the Garg lab offers practical ways to synthesize such "impossible" species but how novel and ground-breaking is this From Julius Bredt's studies on camphor in the 19th century to modern-day research pushing the limits of "impossible" molecules we will explore how chemists have defied the odds to create anti-Bredt olefins. Whether you're a synthesis"  
[YouTube Link](https://youtube.com/watch?v=Mq6ACtLcWdQ)  2024-12-13T16:01Z 63.7K followers, 25.5K engagements


"Cursed Carbon with [--] Bonds Chemistry of the Hexamethylbenzene Dication 🤔 Can carbon go beyond the octet rule You might know the situation for CH5+ but what about the extremely cursed hexamethylbenzene dication In this video we explain the context synthesis and bonding situation of this apparently hypervalent carbon. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on"  
[YouTube Link](https://youtube.com/watch?v=pfWvvGRYTIc)  2024-10-30T16:04Z 63.7K followers, 19.3K engagements


"Carbon Just Did WHAT One Electron Carbon-Carbon Bond (Organic Chemistry) 🤔 OH BOY will Organic Chemistry get even harder for struggling students In this video we explain the recent discovery of a one-electron carbon-carbon sigma bond. Although some assume this is completely unprecedented there is long history of one-electron bonds in general. This video explains the context of this scientific advance what's really new about it and the detailed chemistry behind it. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=gi6gvkvUbLQ)  2024-10-18T14:35Z 63.7K followers, 45.3K engagements


"Cancer Breakthrough Scientists find unexpected brain cancer drug #science #medicine #chemistry Imagine finding the Holy Grail on a dusty shelf. This video delves into drug repurposing a promising approach that saves time and cost by using approved medications for new diseases. We explore temozolomide our main weapon against the aggressive brain cancer glioblastoma - its synthesis mechanism and why it just barely extends survival. New research shows antidepressants like vortioxetine might have value as add-on therapies. Could this unexpected duo be the next step or even cure in the fight"  
[YouTube Link](https://youtube.com/watch?v=zHVSaL5LcSg)  2024-10-07T18:28Z 63.7K followers, [----] engagements


"Treating Brain Cancer with a $50 Antidepressant Drug Repurposing in Glioblastoma Imagine finding the Holy Grail on a dusty shelf. This video delves into drug repurposing a promising approach that saves time and cost by using approved medications for new diseases. We explore temozolomide our main weapon against the aggressive brain cancer glioblastoma - its synthesis mechanism and why it just barely extends survival. New research shows antidepressants like vortioxetine might have value as add-on therapies. Could this unexpected duo be the next step or even cure in the fight against"  
[YouTube Link](https://youtube.com/watch?v=qwLjV_A3hNg)  2024-10-07T15:02Z 63.7K followers, 20.9K engagements


"Why MDMA did NOT get FDA approval 🤔 Some call it surprising others saw it coming: MDMA-assisted therapy in PTSD will not be approved in the near-term future as the US FDA requests additional Phase [--] data to show more conclusive safety and evidence benefits. What might be reasons for the rejection despite the significant hopes In this video we will look at different public opinions and case reports. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters"  
[YouTube Link](https://youtube.com/watch?v=Qdaf77P9Efo)  2024-08-11T17:26Z 63.7K followers, 21.4K engagements


"This New Chemical is Fascinating But How Does it React Diazo-Ylide Hybrid 🤯 This a REALLY strange but surprisingly stable and versatile chemical. We all know carbenes but have you ever heard of carbones This reagent reactivities you might already know from the Wittig reaction Seyferth-Gilbert homologation and diazo chemistry. In this video we explore its synthesis properties with intriguing resonance structures and reactions. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all"  
[YouTube Link](https://youtube.com/watch?v=Oqd71V8c3Ac)  2024-08-03T14:59Z 63.7K followers, 15.7K engagements


"This Surprising Synthesis Will Teach You Organic Chemistry (Rauvomine B) 🤯 "Protecting groups protect" - Makes sense right Well until it doesn't. In this video we will learn more about this and explore interesting organic chemistry reactions by studying the total synthesis of rauvomine B (note: not peer reviewed yet so it could be all made up). https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me"  
[YouTube Link](https://youtube.com/watch?v=igTCAgC1gfg)  2024-07-06T14:06Z 63.7K followers, 19.4K engagements


"Why The Worlds First Drugs Ate Your Butt Cheeks and Turned You Blue 💉 Whether we like it or not drugs are a fundamental part of our modern world. But what were "early drugs" like back in the day At some point we clearly moved from drilling holes in people's skulls to using synthetic molecules as medicines. In this video we will walk through the history science and chemistry of some of the early advances. If you want to fully appreciate the content of upcoming videos on (shocking) history of cancer treatments and modern chemotherapies you should pay attention"  
[YouTube Link](https://youtube.com/watch?v=geOmYSkdSuQ)  2024-06-09T14:00Z 63.7K followers, 33.7K engagements


"This Drug Synthesis is Literally Breathtaking Medicinal Chemistry & Organic Synthesis This molecule might look like any other 'flat drug' - but there's a mystery hidden behind its synthesis Coupled with the fact that it showed promise in asthma due to its novel mechanism you could say that it's breath-taking (actually more like breath-giving but I figured no one will understand this). Watch this video to learn more about organic synthesis drug development and more https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=DGJ0UaZuSWo)  2024-05-04T14:37Z 63.7K followers, 57.8K engagements


"Epic First Cocaine Synthesis in [--] Steps (Educational) Cocaine is intertwined with the fabric of society and science in more profound ways than most realize. Join us to hear about 1) current data on cocaine use 2) history and discovery of cocaine 3) the first landmark total synthesis of cocaine by Richard Wilsttter and 4) other evolutions of (bio)chemical synthesis (Robinson Noyori). Note that we do not cover biological origins isolation or other aspects in detail. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=7xoPNlV3_LA)  2024-03-23T15:05Z 63.7K followers, 166.2K engagements


"E2 Elimination in Organic Chemistry: Explanation of Mechanisms Orbitals and Selectivity 👀 This video explains E2 eliminations: basics of geometries orbitals selectivities. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news https://total-synthesis.com The bimolecular elimination (E2 elimination) reaction is a cornerstone of organic chemistry particularly for synthesis of alkenes. In the E2 mechanism a base abstracts a proton"  
[YouTube Link](https://youtube.com/watch?v=GpQSatsfvMw)  2024-03-17T19:55Z 63.7K followers, [----] engagements


"How E2 Elimination Reactions Work (Animation) Mechanism & Orbitals Organic Chemistry 👀 This video explains E2 eliminations: basics of geometries orbitals selectivities. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research chemistry problems and interesting news https://total-synthesis.com 00:00 E2 elimination basics and orbitals 01:14 Ask yourself these"  
[YouTube Link](https://youtube.com/watch?v=-LpylzP0Wso)  2024-03-17T15:49Z 63.7K followers, [----] engagements


"How Chemists Make Carbon 2+ (Octet Rule: Violated) Organic Chemistry & Synthesis Yep you're looking at a carbon with four valence electrons. How can such an unfavorable species be synthesized how is it stabilized and how does it behave Watch this video to learn exotic chemical reactions and unique properties and geometries - which you likely have never seen before https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters"  
[YouTube Link](https://youtube.com/watch?v=0r-8sRgnnhI)  2024-02-04T15:37Z 63.7K followers, 10.9K engagements


"How Do SN2 Reactions Work (Animation) Organic Chemistry Substitution Mechanism #shorts #short 👀 Let's take a "more visual look" (is that a pleonasm) at SN2 reactions geometries and molecular structures. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news https://total-synthesis.com Some recommended books on organic synthesis: - Clayden Greeves Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt Warren;"  
[YouTube Link](https://youtube.com/watch?v=L_VBzuLIg2s)  2024-01-14T20:46Z 63.7K followers, 17.8K engagements


"How SN2 Reactions Look Like (Animation) Organic Chemistry Substitution Mechanism 👀 Let's take a look at SN2 reactions geometries and molecular visualizations. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news https://total-synthesis.com 00:00 Classic SN2 reaction (Williamson ether synthesis) 02:14 Sterics in SN2"  
[YouTube Link](https://youtube.com/watch?v=MYszpIgJ_mM)  2024-01-14T16:03Z 63.7K followers, [----] engagements


"Why "Horror Drugs" Sold for Billions After the Tragedy (Science of Thalidomide) 👶 You are wrong if you think that the thalidomide tragedy put an end to this molecule. Scientifically - with all due respect to harmed individuals - this molecule proved to be incredibly innovative unlocking a completely new mechanism of action of "therapeutic glues". ❓ What is thalidomide Why is one enantiomer safe and the other is not In this video we uncover the history chemistry biology and pharmacology of thalidomide and related molecules like lenalidomide. If you are a science enthusiast or interested in"  
[YouTube Link](https://youtube.com/watch?v=uzRhjOGT1hU)  2023-12-20T16:31Z 63.7K followers, 17.5K engagements


"Obesity Drug "Tricks" Your Body Into Burning Fat Exercise Mimetics Science 👀 Do you want to get fit without dieting or exercising by tricking your body This sounds like sci-fi or like a scammy ad for a fat burning supplement. However given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound) this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332 a small molecule that mimics endurance training and dieting in mice - without"  
[YouTube Link](https://youtube.com/watch?v=S_U1D1yvj-E)  2023-11-19T15:22Z 63.7K followers, 18.3K engagements


"Extreme Diels-Alder Reactions Your Chemistry Teacher Warned You About 🧠 Remember your chemistry introduction to Diels-Alder reactions At that time these extreme reactions would have been beyond your wildest imagination. If you want to learn some unique aspects to one of the most versatile and robust reactions known to chemists check out this video We will focus on two natural product total syntheses covering basic organic chemistry and advanced synthesis. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=cek60gZO3es)  2023-10-22T15:35Z 63.7K followers, 15.6K engagements


"Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction Psychedelic Science This video explains biochemistry organic synthesis and physiological effects - including pre-clinical research on mice/ rats - of ibogaine ibogamine and other related molecules which might prove useful as the need for effective therapies against substance use disorder and other addiction disorders increase. If you like the video consider commenting sharing it with a fellow nerd and subscribing to the channel so you do not miss future videos"  
[YouTube Link](https://youtube.com/watch?v=W3xuJ0TQQ-w)  2023-09-17T15:01Z 63.7K followers, 34.7K engagements


"The Disturbing Truth About New Medicines: Are They Really Better (Pharmaceutical Chemistry) 🤑 Are newly approved drugs indeed therapeutically superior to already existing medicines Does their pricing reflect their benefit Are drugs with breakthrough designations and accelerated approvals actually more impactful than normal therapeutics Watch this video to learn about these elements and more Please drop a like and comment to support the video's visibility activate notifications and subscribe to the channel so you do not miss future videos https://www.patreon.com/totalsynthesis 🚀 Thanks to"  
[YouTube Link](https://youtube.com/watch?v=FDWrxUMXk0o)  2023-08-22T15:15Z 63.7K followers, [----] engagements


"Worlds Most EXPENSIVE Medicines: Greedy or Fair What Makes them Special (Gene Therapy Chemistry) 🤑 Imagine a single dose of medicine priced at $3.5 MILLION. Since the approval of the gene therapy Hemgenix this is a reality. How can this be fair Stay tuned to better understand the costs and risks of drug development learn about the world's most expensive gene therapy and small molecule and learn some new things about science. Please drop a like and comment to support the video's visibility activate notifications and subscribe to the channel so you do not miss future videos"  
[YouTube Link](https://youtube.com/watch?v=lIz0sbZ1P6A)  2023-07-21T16:08Z 63.7K followers, 23.2K engagements


"Psilocybin Synthesis in [--] Steps & How Magic Mushrooms Rewire Brain Networks (Psychedelic Science) 🍄 Psilocybin is emerging as a promising "therapeutic psychedelic" across various different conditions and diseases. What is the buzz about and how does psilocybin work In this video we dive into psilocybin's rich history chemical structure and biochemical mechanism of action. This includes striking effects like dendritogenesis and synaptic rewiring in mice. We will review a large scale synthesis of psilocybin delivering an impressive [---] kg of cGMP material for clinical supply - this works using"  
[YouTube Link](https://youtube.com/watch?v=vH-TOn9d1pE)  2023-05-14T13:00Z 63.7K followers, 465.2K engagements


"Genius CUBANE Synthesis by Nobel Laureate & Overpriced Drugs Organic Chemistry (MacMillan) 🤔 Cubane is a frequently discussed - and highly coveted - top chemistry meme molecule. This interdisciplinary video showcases the synthesis and application of cubanes in medicinal chemistry by presenting research work from MacMillan and co-workers. Given their proof-of-concept on the cystic fibrosis drug Lumacaftor we also walk through a high-level primer on cystic fibrosis disease landscape and current treatments. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic"  
[YouTube Link](https://youtube.com/watch?v=uQ3YLRpaMlU)  2023-05-05T17:00Z 63.7K followers, 21.9K engagements


"Organic Chemistry Masterclass: Insanely complex neuroprotective Illisimonin A (+reaction mechanisms) ⚠ This video contains advanced organic chemistry Illisimonin A is the perfect quest for synthesis practicioners - it is bioactive (neurotrophic) structurally complex and highly oxygenated. This video will explain the isolation of this illicium-derived natural product and properties. Two modern syntheses (2019 and 2023) will be discussed highlighting unique approaches and common methodologies to access this interesting target. https://total-synthesis.com/organic-chemistry-practice-problems/"  
[YouTube Link](https://youtube.com/watch?v=0UwqcOGSwn0)  2023-04-15T15:19Z 63.7K followers, 15.6K engagements


"MDMA synthesis in [--] steps & how it could help PTSD therapy (educational) Chemistry & Science 🧠 Did you know that MDMA-assisted therapy was recently suggested to be highly effective for people with severe PTSD In this video we will break down MDMA's history and discovery synthetic approaches from the literature - including a kilo-scale process route - and clinical data from a Phase [--] study investigating MDMA's therapeutic benefit. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to"  
[YouTube Link](https://youtube.com/watch?v=onaKmEUtNbc)  2023-03-26T15:36Z 63.7K followers, 270.3K engagements


"This Cursed Molecule Will Teach You About Aromaticity Pagodane & dodecahedrane synthesis chemistry 🧠 The chemists who discovered pagodane described it simply but accurately: this is a highly complex aesthetically appealing molecule. In this video you will see how Prinzbach and co-workers used quite straight-forward chemical reactions to synthesize the impressive pagodane leveraging symmetry and inherent reactivity. Also we will learn how it's connected to the isomer dodecahedrane and the unique case of sigma-bishomoaromaticity present in one of its derivatives."  
[YouTube Link](https://youtube.com/watch?v=H6F8-lu0owQ)  2023-03-19T15:57Z 63.7K followers, 10.8K engagements


"Explosive & Strained Molecular Cubes: Azahomocubane: Organic Chemistry Cubane Synthesis & Mechanisms 💣 In this video we dissect the synthesis and properties of azahomocubane a recently synthesized homocubane 'azalogue'. Is it as unstable or explosive as the malevolent octanitrocubane Watch to find out Please drop a like and comment to support the video's visibility activate notifications and subscribe to the channel so you do not miss future videos https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=24SpQTYRh38)  2023-03-10T15:59Z 63.7K followers, 13.7K engagements


"LSD Synthesis in [--] Steps (Educational) Lysergic acid organic chemistry reaction mechanisms This video does not explain or suggest how to make drugs and is purely educational and theoretical. A team of chemists recently reported a synthesis of lysergic acid the precursor of the psychoactive drug LSD in only [--] laboratory steps. In this video we will learn why LSD-like scaffolds are of interest to modern drug discovery and look into the chemistry of this short but sweet synthesis. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=ieFD-1iHpBw)  2023-02-17T16:15Z 63.7K followers, 725.2K engagements


"How chemists create SUPER-FULLERENE / GRAPHULLERENE Organic Chemistry Physical Chemistry Materials Kekulene is benzene on steroids but is there the equivalent of fullerene on steroids Check out this video for an nice journey into carbon allotropes and physical chemistry. We will learn about graphullerene's interesting synthesis properties and promise for material sciences. PS: No one actually calls it super-fullerene but it makes for a nice title. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=fptPGEYYjac)  2023-02-12T12:18Z 63.7K followers, 16.1K engagements


"Advanced Organic Chemistry: Total Synthesis of Gibberelins Retrosynthesis Mechanisms Gibberelins play a critical role for plants and mankind being vital factors for plant growth and agriculture. They are the reason why we avoided a global hunger wave in the 20th century and their analogs could open new mechanisms of action against cancer This makes synthetic access and further biochemical and pharmacological studies even more important. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀"  
[YouTube Link](https://youtube.com/watch?v=2KeFxPRKqQA)  2023-02-03T13:51Z 63.7K followers, 10.1K engagements


"How chemists create "SUPERBENZENE" (Kekulene) Organic chemistry synthesis & reaction mechanisms 😎 Benzene is the classic example of aromatic stability with n=1 for the Hckel rule of 4*n+2. Big brain chemists also will know more exotic examples for aromaticity (e.g. the cyclopropyl cation). But have you heard of super-aromaticity In this video we will explore the classical (Staab Diederich) and modern (Perez) synthesis of Kekulene. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to"  
[YouTube Link](https://youtube.com/watch?v=qrBMD_H6jXs)  2023-01-06T15:15Z 63.7K followers, 108.4K engagements


"How "Heavy Hydrogen" makes Drugs work: Deuterium in Pharmaceuticals Organic Chemistry & Synthesis Organic chemistry does not only use abundant forms of atoms but also rare isotopes such as deuterium - the heavy form of hydrogen. Addition of "the D" can completely transform a molecule's reactivity and pharmacokinetic properties. Watch this to find out more about the physical chemistry biochemistry and organic synthesis associated with Deuterium and more specifically the discovery route and large-scale process behind the second deuterated drug to be approved by the US FDA deucravacitinib"  
[YouTube Link](https://youtube.com/watch?v=ztAcL43kCl0)  2023-01-01T17:08Z 63.7K followers, 33.5K engagements


"How scientists discover new drugs against viruses: Medicinal Chemistry & Drug Design (Hepatitis C) Let's explore drug design and medicinal chemistry by looking at the development of Hepatitis C Virus inhibitors https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research mechanism quizzes and interesting news"  
[YouTube Link](https://youtube.com/watch?v=cy2k0eOeozg)  2022-05-19T14:35Z 63.7K followers, 35.9K engagements


"Why COAL MINES could deliver new CANCER MEDICINES Chemistry Total Synthesis #Short #Short Check out my channel for interesting videos on biology and science - always with a connection to synthetic organic chemistry. Scientists have discovered bacteria and fungi that are fighting each other in abandoned contaminated coalmines during which they produce promising anti-cancer and antibiotic natural products that could save thousands of lives. This is a striking example of how much we can learn from organisms that live in extreme conditions. Medicine could learn and gain a lot from these molecules"  
[YouTube Link](https://youtube.com/watch?v=M3pw8XssvkQ)  2022-04-08T17:01Z 63.7K followers, [----] engagements


"Exotic Sources of Cancer Medicines: Total Synthesis of Glionitrin Natural Products (Organic Chem) Scientists have discovered bacteria and fungi that fight each other producing promising anti-cancer and antibiotic natural products. Join us on the journey of learning more about biology and microbes acid mine drainage (AMD) natural product chemistry total synthesis and organic chemistry reaction mechanisms. Even if you are not deeply engaged with total synthesis I am confident that this video will enrich your understanding of natural sciences."  
[YouTube Link](https://youtube.com/watch?v=ZGPrPs2mQY0)  2022-04-08T17:00Z 63.7K followers, 19.8K engagements


"How one of Nature's Most Complex Molecules Is Made: Synthesis of Taxol's "Complicated Cousin" Taxol - a commonly used anticancer drug - is part of a broader family of taxane natural products - which includes Canaxpropellane Taxol's "complicated cousin". We will explore some of the related - and unrelated :) - history biochemistry and chemistry facts and trivia. Even if you are not deeply engaged with total synthesis I am confident that this video will enrich your understanding of natural sciences. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry"  
[YouTube Link](https://youtube.com/watch?v=3B0jzfmJz70)  2021-08-24T19:01Z 63.7K followers, 34.4K engagements


"Organic Chemistry Explained: Total Synthesis of Anti-Cancer Ginkgo Tree Molecule Bilobalide (Corey) Let's explore the tale of the Ginkgo tree and dissect three different total syntheses of Bilobalide a potential "anti-almost everything" molecule from the Ginkgo biloba tree (time-stamps below). Even if you are not deeply engaged with total synthesis I am confident that this video will enrich your understanding of chemistry and natural products to some degree. https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems"  
[YouTube Link](https://youtube.com/watch?v=LCsCCR21NmU)  2021-01-07T20:22Z 63.7K followers, 34.2K engagements


"Organic Chemistry Walkthrough Steroid Total Synthesis: Equilenin Retrosynthesis Reaction Mechanism In this video we will talk about the total synthesis of steroid hormones in the early 20th century. After an introduction into the history of steroids and challenges with steroid and natural product isolation we will go through the retrosynthetic analysis . https://total-synthesis.com/organic-chemistry-practice-problems/ 🧑🎓➡ Free organic chemistry practice problems https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters https://www.instagram.com/totalsynthesis_official/ 👉"  
[YouTube Link](https://youtube.com/watch?v=nNx41RTXgMY)  2018-06-14T16:03Z 63.7K followers, 20.7K engagements

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