#  @healthspanmed Healthspan Healthspan posts on X about health, enzyme, ros, science the most. They currently have [-----] followers and [---] posts still getting attention that total [-----] engagements in the last [--] hours. ### Engagements: [-----] [#](/creator/twitter::1298434617549049857/interactions)  - [--] Week [------] +1,057% - [--] Month [------] +232% - [--] Months [------] +999% - [--] Year [------] +405% ### Mentions: [--] [#](/creator/twitter::1298434617549049857/posts_active)  ### Followers: [-----] [#](/creator/twitter::1298434617549049857/followers)  - [--] Week [-----] +0.42% - [--] Month [-----] +1.10% - [--] Months [-----] +9.90% - [--] Year [-----] +17% ### CreatorRank: [---------] [#](/creator/twitter::1298434617549049857/influencer_rank)  ### Social Influence **Social category influence** [finance](/list/finance) [technology brands](/list/technology-brands) **Social topic influence** [health](/topic/health), [enzyme](/topic/enzyme), [ros](/topic/ros), [science](/topic/science), [accumulation](/topic/accumulation), [brain](/topic/brain), [eggs](/topic/eggs), [university of](/topic/university-of), [has been](/topic/has-been), [longevity](/topic/longevity) **Top assets mentioned** [Enzyme (MLN)](/topic/enzyme) [Oxygen (OXY)](/topic/oxygen) [Serum (SRM)](/topic/serum) [Urolithin A (URO)](/topic/urolithin-a) ### Top Social Posts Top posts by engagements in the last [--] hours "@Blagosklonny If you need any help with graphics for the article our design team can help" [X Link](https://x.com/healthspanmed/status/1674564548182036482) 2023-06-29T23:57Z [----] followers, [---] engagements "1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging. The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions. Here's how it works 👇" [X Link](https://x.com/healthspanmed/status/1678103951588352000) 2023-07-09T18:10Z [----] followers, [----] engagements "2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function. This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves leading to the accumulation of damage over time" [X Link](https://x.com/healthspanmed/status/1678103954247544833) 2023-07-09T18:10Z [----] followers, [---] engagements "16. The fact that senescent cells cannot replicate impacts their size activity and pathology. When a healthy cell is exposed to growth stimuli it can balance out its growth by dividing. Senescent cells cannot share the burden of growth with other cells by simply dividing" [X Link](https://x.com/healthspanmed/status/1678103992721874945) 2023-07-09T18:10Z [----] followers, [--] engagements "17. Instead when senescent cells are exposed to growth signals they: [--]. Become very large [--]. Hyper-mitogenic (causing hyperplasia) [--]. Release molecules that stimulate the proliferation of adjacent cells and are resistant to programmed cell death" [X Link](https://x.com/healthspanmed/status/1678103995288801280) 2023-07-09T18:10Z [----] followers, [--] engagements "20. As we age the proportion of senescent cells increases as they become harder to remove. This has tremendous implications for the acceleration of aging. Seeing senescence as a state of continuous growth without cell division helps us understand systemic aging" [X Link](https://x.com/healthspanmed/status/1678104003840991232) 2023-07-09T18:10Z [----] followers, [--] engagements "21. Many people associate age-related diseases with loss of cellular function. Cellular senescence is often perceived as a manifestation of functional decline or wear-and-tear leading to accumulated cellular damage that exceeds the body's self-repair mechanisms. It's not" [X Link](https://x.com/healthspanmed/status/1678104006437257216) 2023-07-09T18:10Z [----] followers, [--] engagements "39. Lowering mTOR activity represents a broadly applicable treatment to reduce cellular hyper-functions and the following decline of tissue function. Rapamycin is a molecule known to inhibit mTOR activity" [X Link](https://x.com/healthspanmed/status/1678104057590976512) 2023-07-09T18:10Z [----] followers, [--] engagements "40. By suppressing the mTOR pathway rapamycin reduces the release of detrimental molecules from senescent cells. This not only safeguards neighboring tissues from potential harm but also encourages the elimination of these aging cells through autophagy" [X Link](https://x.com/healthspanmed/status/1678104060199837696) 2023-07-09T18:10Z [----] followers, [--] engagements "1. Rapamycin paradoxically suppresses immune function when taken daily at high doses. When taken cyclically at low doses it enhances it. How do mTOR inhibitors like rapamycin may enhance immune function The research of @MannickJoan is critical to understanding how. LG 🧵👇" [X Link](https://x.com/healthspanmed/status/1694696095178510546) 2023-08-24T13:00Z [----] followers, [---] engagements "1) While time-restricted eating (eating within an 8-10 hour window each day) is known to improve organ systems the genomic changes have largely been unknown. A study in @Cell_Metabolism sheds light on the underlying genomic changes. Here's how: 🧵👇" [X Link](https://x.com/healthspanmed/status/1695149058816610362) 2023-08-25T19:00Z [----] followers, [---] engagements "2) Background: Time-restricted feeding has been shown to have a variety of health benefits including improved exercise capacity sleep blood pressure and gut health as well as reduced cancer risk and neurodegenerative disease severity" [X Link](https://x.com/healthspanmed/status/1695149061551296907) 2023-08-25T19:00Z [----] followers, [--] engagements "3) The potential health benefits of TRF may be due to its effects on pathways like mTOR AMPK Sirtuins and insulin/IGF1 signaling which regulate nutrient intake processing and gene expression in the body" [X Link](https://x.com/healthspanmed/status/1695149064483180928) 2023-08-25T19:00Z [----] followers, [--] engagements "1. Recent research has begun to demonstrate that rapamycin may have significant benefits for women's health in: 1) preserving ovarian function 2) extending fertility 3) delaying menopause How does rapamycin work to promote ovarian function Here's the latest research 👇🧵" [X Link](https://x.com/healthspanmed/status/1695360515009286163) 2023-08-26T09:00Z [----] followers, [---] engagements "8. There have been several attempts to restore and maintain oocyte quantity and quality with nutraceutical approaches such as Resveratrol Coenzyme Q10 Vitamin C and NMN to target the increased mitochondrial ROS & DNA damage associated with oocyte aging with limited effects" [X Link](https://x.com/healthspanmed/status/1695360533770408094) 2023-08-26T09:00Z [----] followers, [--] engagements "9. Of these mechanisms mTOR has an often overlooked role in the activation and dysregulation of ovarian growth signaling of primordial follicles. Primordial follicles are the earliest stage of ovarian follicle development and represent the reserve of immature eggs (oocytes)" [X Link](https://x.com/healthspanmed/status/1695360536370979266) 2023-08-26T09:00Z [----] followers, [--] engagements "19. Unlocking the potential of rapamycin as a therapeutic intervention to prevent menopause and enhance ovarian health in women has become an increasingly popular avenue of research for longevity researchers. Let's dive into the latest research" [X Link](https://x.com/healthspanmed/status/1695360562870501867) 2023-08-26T09:00Z [----] followers, [--] engagements "20. Rapamycin and Fertility Recent studies have shown that rapamycin can improve ovarian function and increase the number of eggs produced by the ovaries. In one study female mice treated with rapamycin had a significantly greater egg quality" [X Link](https://x.com/healthspanmed/status/1695360565504577648) 2023-08-26T09:00Z [----] followers, [--] engagements "Topical Rapamycin reduces the occurrence of solar elastosis and disorganized collagen fibers in the skin. By promoting autophagy rapamycin enhances the health of the skin layer by increasing the clearance of damaged cellular components. Learn more:" [X Link](https://x.com/healthspanmed/status/1695586948516397221) 2023-08-27T00:00Z [----] followers, [---] engagements "17. Chronic overactivation of mTOR is at the foundation of many age-related diseases. As we get older mTOR may stay active all the timeopening the door to out-of-control cell growth. It is a driver of toxic cellular hyperactivity leading to the decline of healthy tissue" [X Link](https://x.com/healthspanmed/status/1697398944630980651) 2023-09-01T00:00Z [----] followers, [--] engagements "1) While time-restricted eating (eating within an 8-10 hour window each day) is known to improve organ systems the genomic changes have largely been unknown. A study in @Cell_Metabolism sheds light on the underlying genomic changes. Here's how: 🧵👇" [X Link](https://x.com/healthspanmed/status/1700298002857165216) 2023-09-09T00:00Z [----] followers, [---] engagements "Our founder @dantawfik was on the Wise Athletes podcast where they covered a number of longevity topics: [--]. The importance of @Blagosklonny's theory of hyperfunction. [--]. mTOR driven-aging & senescence. [--]. Rapamycin [--]. Metabolic pathways as levers" [X Link](https://x.com/healthspanmed/status/1705009020782940518) 2023-09-22T00:00Z [----] followers, [---] engagements "30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction" [X Link](https://x.com/healthspanmed/status/1712619239780270356) 2023-10-13T00:00Z [----] followers, [--] engagements "31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability" [X Link](https://x.com/healthspanmed/status/1712619242363981924) 2023-10-13T00:00Z [----] followers, [--] engagements "Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:" [X Link](https://x.com/healthspanmed/status/1712981615960637611) 2023-10-14T00:00Z [----] followers, [----] engagements "While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:" [X Link](https://x.com/healthspanmed/status/1713117464765309377) 2023-10-14T09:00Z [----] followers, [---] engagements "12. Upon identifying these patterns TLR4 instigates an inflammatory cascademarshaling the immune system to counteract infections and manage tissue damage. This series of molecular events culminates in activating specific pro-inflammatory transcription factors" [X Link](https://x.com/healthspanmed/status/1713268506035368223) 2023-10-14T19:00Z [----] followers, [--] engagements "13. When activated these transcription factors boost production of pro-inflammatory agents. These include cytokines like interleukin-1 interleukin-6 and tumor necrosis factor-alpha along with other molecules essential for the inflammatory response" [X Link](https://x.com/healthspanmed/status/1713268508623348177) 2023-10-14T19:00Z [----] followers, [--] engagements "Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging" [X Link](https://x.com/healthspanmed/status/1714280169622650992) 2023-10-17T14:00Z [----] followers, [---] engagements "1. Rapamycin paradoxically suppresses immune function when taken daily at high doses. When taken cyclically at low doses it enhances it. How do mTOR inhibitors like rapamycin may enhance immune function The research of @MannickJoan is critical to understanding how. LG 🧵👇" [X Link](https://x.com/healthspanmed/status/1717692706972164398) 2023-10-27T00:00Z [----] followers, [----] engagements "The fermentation leads to an increase in the production of short-chain fatty acids (SCFAs) and increases the abundance of certain types of beneficial bacteria in the gut such as Bifidobacterium and Lactobacillus" [X Link](https://x.com/healthspanmed/status/1718779888432488691) 2023-10-30T00:00Z [----] followers, [--] engagements "Short-chain fatty acids particularly butyrate were highly correlated with longer lifespans in the ITP. SCFAs may play a critical role in extending longevity and may also produce other signaling molecules that have been associated with longevity benefits" [X Link](https://x.com/healthspanmed/status/1718779891070718003) 2023-10-30T00:00Z [----] followers, [--] engagements "2. Chronic inflammation lies at the core of numerous debilitating diseases from autoimmune disorders to neurodegenerative conditions. While acute inflammation serves a protective purpose chronic inflammation leads to tissue dysfunction and the acceleration of aging" [X Link](https://x.com/healthspanmed/status/1718900654813626553) 2023-10-30T08:00Z [----] followers, [--] engagements "3. In individuals with chronic inflammatory ailments there's a relentless hyperactivity of the immune system. Inflammatory cells discharge signaling molecules known as cytokines. These cytokines play a pivotal role in sustaining an inflammatory response" [X Link](https://x.com/healthspanmed/status/1718900657426759973) 2023-10-30T08:00Z [----] followers, [--] engagements "While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:" [X Link](https://x.com/healthspanmed/status/1719066735243063501) 2023-10-30T19:00Z [----] followers, [---] engagements "1. Photodamage Photodamage is a result of prolonged exposure to UV radiation which can lead to the breakdown of collagen and elastin fibers resulting in wrinkles dyspigmentation and dull-appearing skin" [X Link](https://x.com/healthspanmed/status/1719353716049166549) 2023-10-31T14:00Z [----] followers, [--] engagements "2. Dermal Atrophy Dermal atrophy or skin "thinning" is caused by a reduction in the underlying tissue and can result in a loss of firmness and elasticity. Impaired barrier function causes dryness flakiness and a weakened skin barrier making the skin susceptible to damage" [X Link](https://x.com/healthspanmed/status/1719353718695698715) 2023-10-31T14:00Z [----] followers, [--] engagements "24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and" [X Link](https://x.com/healthspanmed/status/1719655723788116381) 2023-11-01T10:00Z [----] followers, [--] engagements "25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts" [X Link](https://x.com/healthspanmed/status/1719655726476603887) 2023-11-01T10:00Z [----] followers, [--] engagements "While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:" [X Link](https://x.com/healthspanmed/status/1728941769931489444) 2023-11-27T01:00Z [----] followers, [---] engagements "30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction" [X Link](https://x.com/healthspanmed/status/1729228766667473172) 2023-11-27T20:00Z [----] followers, [--] engagements "31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability" [X Link](https://x.com/healthspanmed/status/1729228769658056712) 2023-11-27T20:00Z [----] followers, [--] engagements "Topical Rapamycin reduces the occurrence of solar elastosis and disorganized collagen fibers in the skin. By promoting autophagy rapamycin enhances the health of the skin layer by increasing the clearance of damaged cellular components. Learn more:" [X Link](https://x.com/healthspanmed/status/1731402955805655172) 2023-12-03T20:00Z [----] followers, [---] engagements "24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and" [X Link](https://x.com/healthspanmed/status/1732052381578547246) 2023-12-05T15:00Z [----] followers, [--] engagements "25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts" [X Link](https://x.com/healthspanmed/status/1732052384858444221) 2023-12-05T15:00Z [----] followers, [--] engagements "Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:" [X Link](https://x.com/healthspanmed/status/1732490228781433082) 2023-12-06T20:00Z [----] followers, [---] engagements "28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging" [X Link](https://x.com/healthspanmed/status/1732928169911697432) 2023-12-08T01:00Z [----] followers, [--] engagements "29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How" [X Link](https://x.com/healthspanmed/status/1732928173124513894) 2023-12-08T01:00Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1733215050142495167) 2023-12-08T20:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1733215053762183345) 2023-12-08T20:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1733215057050571153) 2023-12-08T20:00Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1734015214348374236) 2023-12-11T01:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1734015217615642766) 2023-12-11T01:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1734015220908196273) 2023-12-11T01:00Z [----] followers, [--] engagements "Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels" [X Link](https://x.com/healthspanmed/status/1734015224100118576) 2023-12-11T01:00Z [----] followers, [--] engagements "Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues" [X Link](https://x.com/healthspanmed/status/1734015227287810065) 2023-12-11T01:00Z [----] followers, [--] engagements "18. Senescent cells are also hyper-inflammatory. They excrete a witch's brew of inflammatory molecules and growth factors known as the senescence-associated secretory phenotype (SASP) The SASP is a complex set of signaling molecules that damage and stimulate nearby cell growth" [X Link](https://x.com/anyuser/status/1739451024241467613) 2023-12-26T01:00Z [--] followers, [--] engagements "19. As a result senescent cells are effectively "stuck" in a state of high activity with both the gas pedal and the brakes pressed to the floor. The only way for senescent cells to be cleared is through the action of nearby immune cells which can recognize and remove them" [X Link](https://x.com/healthspanmed/status/1739451027479581144) 2023-12-26T01:00Z [----] followers, [--] engagements "28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging" [X Link](https://x.com/anyuser/status/1739451056676045095) 2023-12-26T01:00Z [--] followers, [--] engagements "29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How" [X Link](https://x.com/healthspanmed/status/1739451059935039730) 2023-12-26T01:00Z [----] followers, [--] engagements "30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction" [X Link](https://x.com/healthspanmed/status/1739451063164600588) 2023-12-26T01:00Z [----] followers, [--] engagements "31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability" [X Link](https://x.com/healthspanmed/status/1739451066381693154) 2023-12-26T01:00Z [----] followers, [--] engagements "1. People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇" [X Link](https://x.com/healthspanmed/status/1739662494128558560) 2023-12-26T15:00Z [----] followers, [----] engagements "Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels" [X Link](https://x.com/healthspanmed/status/1739964504304394366) 2023-12-27T11:00Z [----] followers, [--] engagements "Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues" [X Link](https://x.com/healthspanmed/status/1739964507529806178) 2023-12-27T11:00Z [----] followers, [--] engagements "Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Watch our full breakdown about the potential use of rapamycin as an Alzheimer's prophylactic:" [X Link](https://x.com/anyuser/status/1750607747194999185) 2024-01-25T19:53Z [--] followers, [---] engagements "28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging" [X Link](https://x.com/healthspanmed/status/1752497073860255895) 2024-01-31T01:00Z [----] followers, [--] engagements "29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How" [X Link](https://x.com/healthspanmed/status/1752497077144445143) 2024-01-31T01:00Z [----] followers, [--] engagements "1. People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇" [X Link](https://x.com/healthspanmed/status/1752783882511118472) 2024-01-31T20:00Z [----] followers, [---] engagements "3. Muscles are composed of two main types of fibers: slow-twitch type I fibers and fast-twitch type II fibers. Type II muscle fibers are like sprinters offering high-energy bursts Type I fibers resemble marathon runners known for their endurance and rich mitochondrial content" [X Link](https://x.com/healthspanmed/status/1752861337829667012) 2024-02-01T01:08Z [----] followers, [--] engagements "4. As we age our immune function declines accompanied by increased pro-inflammatory agents (IL-1 IL-6 TNF-). This inflammation sets off a cascade of events: - impaired mitochondria that produce less energy - More reactive oxygen species (ROS) that damage mitochondria" [X Link](https://x.com/healthspanmed/status/1752861341222871055) 2024-02-01T01:08Z [----] followers, [--] engagements "20. As we age mTOR may stay active all the timeopening the door to out-of-control cell growth. This means we are not seeing the level of clearance of damaged mitochondria and damaged cellular proteins. With damaged mitochondria you have less efficient glucose metabolism" [X Link](https://x.com/healthspanmed/status/1752861392879899057) 2024-02-01T01:08Z [----] followers, [--] engagements "21. Mitochondrial dysfunction is another link between cognitive decline and sarcopenia. Mitochondrial dysfunction in aging is partly due to accumulated damage from mitochondrial DNA mutations and Reactive Oxygen Species (ROS) which cause cellular molecular damage" [X Link](https://x.com/healthspanmed/status/1752861396117950647) 2024-02-01T01:08Z [----] followers, [--] engagements "31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties" [X Link](https://x.com/healthspanmed/status/1752861428355358738) 2024-02-01T01:08Z [----] followers, [--] engagements "32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts" [X Link](https://x.com/healthspanmed/status/1752861431635349911) 2024-02-01T01:08Z [----] followers, [--] engagements "35. Blocking trans-signaling can halt disease progression pointing towards its critical role in inflammatory pathologies and inflamm-aging in the CNS. So we know that IL-6 signaling is a culprit in a number of chronic inflammatory conditions. This is important" [X Link](https://x.com/healthspanmed/status/1752861441391259865) 2024-02-01T01:08Z [----] followers, [--] engagements "36. Here's where modern lifestyles come into the picture. Obese individuals often have increased levels of IL-6R and the enzyme ADAM17. The ADAM17 enzyme is responsible for creating that soluble IL-6 receptor we talked about. It enables the more harmful trans-signaling" [X Link](https://x.com/healthspanmed/status/1752861444738302204) 2024-02-01T01:08Z [----] followers, [--] engagements "41. When muscles remain dormant and inactive they tend to limit their endocrine capabilities. This means that less myokines are released. This shift leans towards promoting inflammation which in the long run can escalate the risk of dementia" [X Link](https://x.com/healthspanmed/status/1752861460810830169) 2024-02-01T01:08Z [----] followers, [--] engagements "42. What does this mean for the brain Myokines have the potential to relay the benefits of physical activity to the brain potentially promoting neurogenesis and combating neurodegenerative diseases. However they must first breach the formidable blood-brain barrier" [X Link](https://x.com/healthspanmed/status/1752861464237609457) 2024-02-01T01:08Z [----] followers, [--] engagements "49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years" [X Link](https://x.com/healthspanmed/status/1752861487004328180) 2024-02-01T01:08Z [----] followers, [--] engagements "50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point" [X Link](https://x.com/healthspanmed/status/1752861490242318652) 2024-02-01T01:08Z [----] followers, [--] engagements "72. Are the deficits in brain insulin directly tied to the spike in peripheral insulin levels especially those accentuated by a decline in skeletal muscle mass Or could there be other factors hidden threads we've yet to discover that contribute to this delicate balance" [X Link](https://x.com/healthspanmed/status/1752861561981739366) 2024-02-01T01:08Z [----] followers, [--] engagements "73. Alzheimer's Disease provides a compelling backdrop for this exploration. The myriad of mechanisms linking peripheral hyperinsulinemia to AD creates a maze of biological interactions. The intricate interaction between the insulin-degrading enzyme (IDE) and A stands out" [X Link](https://x.com/healthspanmed/status/1752861565140038101) 2024-02-01T01:08Z [----] followers, [--] engagements "74. Insulin-degrading enzyme (IDE) is an enzyme that's responsible for degrading insulin once it has fulfilled its role. But beyond insulin IDE is also known to degrade other small peptides including A. This dual role makes an important enzyme for cognitive health" [X Link](https://x.com/healthspanmed/status/1752861568327708792) 2024-02-01T01:08Z [----] followers, [--] engagements "87. 🚨 Mechanism 4: Mitochondrial Dysfunction The mitochondrion crucial for skeletal muscle energy conducts key processes like ATP synthesis through oxidative phosphorylation apoptosis regulation and ROS production control If one process falters it risks system dysfunction" [X Link](https://x.com/healthspanmed/status/1752861612334276844) 2024-02-01T01:09Z [----] followers, [--] engagements "88. Reactive oxygen and nitrogen species (RONS) are crucial in cellular signaling within muscle tissues. While normally beneficial excessive RONS production leads to oxidative stress damaging cells and their structures" [X Link](https://x.com/healthspanmed/status/1752861615660401149) 2024-02-01T01:09Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1753720065550352565) 2024-02-03T10:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1753720068754858157) 2024-02-03T10:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1753720071996981444) 2024-02-03T10:00Z [----] followers, [--] engagements "31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties" [X Link](https://x.com/healthspanmed/status/1755592459214782465) 2024-02-08T14:00Z [----] followers, [--] engagements "32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts" [X Link](https://x.com/healthspanmed/status/1755592462935163336) 2024-02-08T14:00Z [----] followers, [--] engagements "35. Blocking trans-signaling can halt disease progression pointing towards its critical role in inflammatory pathologies and inflamm-aging in the CNS. So we know that IL-6 signaling is a culprit in a number of chronic inflammatory conditions. This is important" [X Link](https://x.com/healthspanmed/status/1755592473416712652) 2024-02-08T14:00Z [----] followers, [--] engagements "36. Here's where modern lifestyles come into the picture. Obese individuals often have increased levels of IL-6R and the enzyme ADAM17. The ADAM17 enzyme is responsible for creating that soluble IL-6 receptor we talked about. It enables the more harmful trans-signaling" [X Link](https://x.com/healthspanmed/status/1755592477044879843) 2024-02-08T14:00Z [----] followers, [--] engagements "41. When muscles remain dormant and inactive they tend to limit their endocrine capabilities. This means that less myokines are released. This shift leans towards promoting inflammation which in the long run can escalate the risk of dementia" [X Link](https://x.com/healthspanmed/status/1755592494870598044) 2024-02-08T14:00Z [----] followers, [--] engagements "42. What does this mean for the brain Myokines have the potential to relay the benefits of physical activity to the brain potentially promoting neurogenesis and combating neurodegenerative diseases. However they must first breach the formidable blood-brain barrier" [X Link](https://x.com/healthspanmed/status/1755592498490261671) 2024-02-08T14:00Z [----] followers, [--] engagements "49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years" [X Link](https://x.com/healthspanmed/status/1755592523404456400) 2024-02-08T14:00Z [----] followers, [--] engagements "50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point" [X Link](https://x.com/healthspanmed/status/1755592526873145651) 2024-02-08T14:00Z [----] followers, [--] engagements "72. Are the deficits in brain insulin directly tied to the spike in peripheral insulin levels especially those accentuated by a decline in skeletal muscle mass Or could there be other factors hidden threads we've yet to discover that contribute to this delicate balance" [X Link](https://x.com/healthspanmed/status/1755592605377998932) 2024-02-08T14:01Z [----] followers, [--] engagements "73. Alzheimer's Disease provides a compelling backdrop for this exploration. The myriad of mechanisms linking peripheral hyperinsulinemia to AD creates a maze of biological interactions. The intricate interaction between the insulin-degrading enzyme (IDE) and A stands out" [X Link](https://x.com/healthspanmed/status/1755592608876056980) 2024-02-08T14:01Z [----] followers, [--] engagements "74. Insulin-degrading enzyme (IDE) is an enzyme that's responsible for degrading insulin once it has fulfilled its role. But beyond insulin IDE is also known to degrade other small peptides including A. This dual role makes an important enzyme for cognitive health" [X Link](https://x.com/healthspanmed/status/1755592612399255939) 2024-02-08T14:01Z [----] followers, [--] engagements "31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties" [X Link](https://x.com/healthspanmed/status/1758129206872141956) 2024-02-15T14:00Z [----] followers, [--] engagements "32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts" [X Link](https://x.com/healthspanmed/status/1758129211620106475) 2024-02-15T14:00Z [----] followers, [--] engagements "49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years" [X Link](https://x.com/healthspanmed/status/1758129272437485720) 2024-02-15T14:00Z [----] followers, [--] engagements "50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point" [X Link](https://x.com/healthspanmed/status/1758129276115947816) 2024-02-15T14:00Z [----] followers, [--] engagements "58. Insulin resistance has emerged as a serious risk factor potentially steering the ship towards cognitive decline. This suggests that our muscles and their role in glucose management are inextricably linked to our physical well-being and cognitive health" [X Link](https://x.com/healthspanmed/status/1758129304578486474) 2024-02-15T14:01Z [----] followers, [--] engagements "59. Aging often leads to a detrimental cycle of impaired glucose tolerance and insulin resistance which is linked to changes in brain function and regional cerebral blood flow in older individuals even without cognitive dysfunction. The brain relies on glucose" [X Link](https://x.com/healthspanmed/status/1758129308059816291) 2024-02-15T14:01Z [----] followers, [--] engagements "61. With aging insulin resistance worsens. Insulin and glucose crossing the blood-brain barrier (BBB) affect the brain by remodeling synapses influencing neurotransmitter expression and improving glucose metabolism in certain brain areas" [X Link](https://x.com/healthspanmed/status/1758129315273945600) 2024-02-15T14:01Z [----] followers, [--] engagements "62. When there's an excess of insulin in the blood it damages this system by reducing the number of insulin receptors in the blood brain barrier. Think of it as closing the gates to the brain which then restricts the flow of insulin inside. The outcome" [X Link](https://x.com/healthspanmed/status/1758129318927163521) 2024-02-15T14:01Z [----] followers, [--] engagements "25. Conditions like Fibromyalgia may be linked to chronic glial cell activation and neuroinflammation. The similarity in symptoms between Fibromyalgia and cytokine-induced sickness suggests LDN's anti-inflammatory impact might stem from its effect on microglial activation" [X Link](https://x.com/healthspanmed/status/1758416081323176148) 2024-02-16T09:00Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1758793435333693799) 2024-02-17T10:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1758793438517154219) 2024-02-17T10:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1758793441738412044) 2024-02-17T10:00Z [----] followers, [--] engagements "Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels" [X Link](https://x.com/healthspanmed/status/1758793444913529108) 2024-02-17T10:00Z [----] followers, [--] engagements "Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues" [X Link](https://x.com/healthspanmed/status/1758793448143122495) 2024-02-17T10:00Z [----] followers, [--] engagements "Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:" [X Link](https://x.com/healthspanmed/status/1758944442680320027) 2024-02-17T20:00Z [----] followers, [---] engagements "@Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging. The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions. Here's how it works 👇" [X Link](https://x.com/healthspanmed/status/1784658853763923994) 2024-04-28T19:00Z [----] followers, [---] engagements "Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function. This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves leading to the accumulation of damage over time" [X Link](https://x.com/healthspanmed/status/1784658868611801576) 2024-04-28T19:00Z [----] followers, [--] engagements "It is the hyperfunction of the smooth muscle cells that leads to the loss of function of the tissue. Cellular hyperfunction hyperplasia and hypertrophy of smooth muscle cells lead to atherosclerosis and hypertension ultimately leading to strokes and myocardial function" [X Link](https://x.com/healthspanmed/status/1784659188821712968) 2024-04-28T19:01Z [----] followers, [--] engagements "@Blagosklonny connects nearly every age-related disease to hyperactivity rather than loss of cellular output. Here are some more examples. Osteoporosis 🚨 In osteoporosis osteoclasts become outsized and overactive leading to the resorption of bone tissue" [X Link](https://x.com/healthspanmed/status/1784659203040399537) 2024-04-28T19:01Z [----] followers, [--] engagements "The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging" [X Link](https://x.com/healthspanmed/status/1784659245943882100) 2024-04-28T19:01Z [----] followers, [--] engagements "These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How" [X Link](https://x.com/healthspanmed/status/1784659260225524193) 2024-04-28T19:01Z [----] followers, [--] engagements "By suppressing the mTOR pathway rapamycin reduces the release of detrimental molecules from senescent cells. This not only safeguards neighboring tissues from potential harm but also encourages the elimination of these aging cells through autophagy" [X Link](https://x.com/healthspanmed/status/1784659417272897948) 2024-04-28T19:02Z [----] followers, [--] engagements "Rapamycin plays a crucial role in decelerating the accumulation of cellular damage and reducing the overall population of senescent cells thereby mitigating their harmful effects on our bodies" [X Link](https://x.com/healthspanmed/status/1784659431487349231) 2024-04-28T19:02Z [----] followers, [--] engagements "Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel" [X Link](https://x.com/healthspanmed/status/1785768673162272807) 2024-05-01T20:30Z [----] followers, [---] engagements "New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/" [X Link](https://x.com/healthspanmed/status/1786546289716678923) 2024-05-04T00:00Z [----] followers, [---] engagements "24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and" [X Link](https://x.com/healthspanmed/status/1787920668669120564) 2024-05-07T19:01Z [----] followers, [---] engagements "25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts" [X Link](https://x.com/healthspanmed/status/1787920683013754988) 2024-05-07T19:01Z [----] followers, [--] engagements "Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel" [X Link](https://x.com/healthspanmed/status/1788554615505711337) 2024-05-09T13:00Z [----] followers, [---] engagements "1) A recent study investigated the potential of rapamycin to slow down skin senescence when applied topically. The results were striking. Markers of skin senescence dropped by 50%. What are the molecular changes to the skin after rapamycin treatment Let's dive in 🧵👇" [X Link](https://x.com/healthspanmed/status/1789445398857400829) 2024-05-12T00:00Z [----] followers, [---] engagements "2) Mechanism 1: Rapamycin Reduced P16 Derived Inflammation The researchers focused on a protein called p16INK4A (p16) which is involved in regulating the cell cycle and senescence. P16 is expressed at high levels in the skin and has been linked to skin aging" [X Link](https://x.com/healthspanmed/status/1789445413386526879) 2024-05-12T00:00Z [----] followers, [--] engagements "3) In addition to its role in senescence p16 is involved in regulating inflammation in the skin. Inflammation is a key factor in skin aging and high levels of inflammation in the skin have been associated with the development of wrinkles and other signs of aging" [X Link](https://x.com/healthspanmed/status/1789445427613647177) 2024-05-12T00:00Z [----] followers, [--] engagements "5) Mechanism 2: Topical Rapamycin Reduces Solar Elastosis Researchers also assessed the levels of a skin condition known as solar elastosis. This condition is commonly seen in individuals who have experienced chronic sun exposure particularly in the face neck and hands" [X Link](https://x.com/healthspanmed/status/1789445464649335234) 2024-05-12T00:00Z [----] followers, [--] engagements "6) Solar elastosis occurs when abnormal elastic fibers accumulate in the skin resulting in a thickened and yellowed appearance. It is a key feature of actinic keratoses which are pre-cancerous skin lesions caused by sun damage" [X Link](https://x.com/healthspanmed/status/1789445479056752919) 2024-05-12T00:00Z [----] followers, [--] engagements "10) Moreover cytokeratin [--] is thought to regulate the process of mitosis which is crucial in the replacement of the skin cells that are shed from the surface of the skin" [X Link](https://x.com/healthspanmed/status/1789445546664694199) 2024-05-12T00:00Z [----] followers, [--] engagements "11) Researchers found that in the skin samples from people who had used the rapamycin cream the staining for cytokeratin 5/6 was more focused in the basal layer of the skin. Skin samples from the placebo cream showed staining for cytokeratin 5/6 in a different layer of the skin" [X Link](https://x.com/healthspanmed/status/1789445568407986321) 2024-05-12T00:00Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1790094791465906286) 2024-05-13T19:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1790094805567156549) 2024-05-13T19:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1790094819831996577) 2024-05-13T19:00Z [----] followers, [--] engagements "Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels" [X Link](https://x.com/healthspanmed/status/1790094834054869408) 2024-05-13T19:00Z [----] followers, [--] engagements "Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues" [X Link](https://x.com/healthspanmed/status/1790094848193867791) 2024-05-13T19:00Z [----] followers, [--] engagements "Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction" [X Link](https://x.com/healthspanmed/status/1794081358123503918) 2024-05-24T19:01Z [----] followers, [--] engagements "Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability" [X Link](https://x.com/healthspanmed/status/1794081372166058322) 2024-05-24T19:01Z [----] followers, [--] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1794443407659847753) 2024-05-25T19:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1794443421798846497) 2024-05-25T19:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1794443435958739289) 2024-05-25T19:00Z [----] followers, [--] engagements "Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic: https://gethealthspan.com/blog/articles/mtor-signaling-neurodegenerative-disorders-therapeutic-potential-rapamycin/5rzr6cmf1xclamddflgp2k/ https://gethealthspan.com/blog/articles/mtor-signaling-neurodegenerative-disorders-therapeutic-potential-rapamycin/5rzr6cmf1xclamddflgp2k/" [X Link](https://x.com/healthspanmed/status/1820897695973961963) 2024-08-06T19:00Z [----] followers, [---] engagements "There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule" [X Link](https://x.com/healthspanmed/status/1821260158930186324) 2024-08-07T19:00Z [----] followers, [--] engagements "Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine" [X Link](https://x.com/healthspanmed/status/1821260181776556344) 2024-08-07T19:00Z [----] followers, [--] engagements "By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose" [X Link](https://x.com/healthspanmed/status/1821260204622934388) 2024-08-07T19:00Z [----] followers, [--] engagements "Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels" [X Link](https://x.com/healthspanmed/status/1821260227674825076) 2024-08-07T19:00Z [----] followers, [--] engagements "Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues" [X Link](https://x.com/healthspanmed/status/1821260250458288456) 2024-08-07T19:00Z [----] followers, [--] engagements "24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and" [X Link](https://x.com/healthspanmed/status/1822423207275909202) 2024-08-11T00:02Z [----] followers, [--] engagements "25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts" [X Link](https://x.com/healthspanmed/status/1822423229962862752) 2024-08-11T00:02Z [----] followers, [--] engagements "New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/" [X Link](https://x.com/healthspanmed/status/1823509860694286371) 2024-08-14T00:00Z [----] followers, [---] engagements "People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇" [X Link](https://x.com/healthspanmed/status/1823796752421675059) 2024-08-14T19:00Z [----] followers, [---] engagements "Chronic inflammation lies at the core of numerous debilitating diseases from autoimmune disorders to neurodegenerative conditions. While acute inflammation serves a protective purpose chronic inflammation leads to tissue dysfunction and the acceleration of aging" [X Link](https://x.com/healthspanmed/status/1823796775775559734) 2024-08-14T19:00Z [----] followers, [--] engagements "2) Mechanism 1: Rapamycin Reduced P16 Derived Inflammation The researchers focused on a protein called p16INK4A (p16) which is involved in regulating the cell cycle and senescence. P16 is expressed at high levels in the skin and has been linked to skin aging" [X Link](https://x.com/healthspanmed/status/1825971172112298045) 2024-08-20T19:00Z [----] followers, [--] engagements "3) In addition to its role in senescence p16 is involved in regulating inflammation in the skin. Inflammation is a key factor in skin aging and high levels of inflammation in the skin have been associated with the development of wrinkles and other signs of aging" [X Link](https://x.com/healthspanmed/status/1825971194732097685) 2024-08-20T19:00Z [----] followers, [--] engagements "5) Mechanism 2: Topical Rapamycin Reduces Solar Elastosis Researchers also assessed the levels of a skin condition known as solar elastosis. This condition is commonly seen in individuals who have experienced chronic sun exposure particularly in the face neck and hands" [X Link](https://x.com/healthspanmed/status/1825971252563161579) 2024-08-20T19:00Z [----] followers, [--] engagements "6) Solar elastosis occurs when abnormal elastic fibers accumulate in the skin resulting in a thickened and yellowed appearance. It is a key feature of actinic keratoses which are pre-cancerous skin lesions caused by sun damage" [X Link](https://x.com/healthspanmed/status/1825971275287945593) 2024-08-20T19:00Z [----] followers, [--] engagements "7) When analyzing the histological images the researchers found that the placebo group had significantly higher levels of disorganized collagen fibers which are associated with sun damage as well as evidence of solar elastosis" [X Link](https://x.com/healthspanmed/status/1825971307399491755) 2024-08-20T19:00Z [----] followers, [--] engagements "8) Mechanism 4: Cytokeratin 5/6 Distribution in the Basal Layer Improves with Rapamycin Treatment The skin biopsies also revealed that rapamycin had a positive effect on the distribution of cytokeratin 5/6 in the basal layer" [X Link](https://x.com/healthspanmed/status/1825971330837340531) 2024-08-20T19:01Z [----] followers, [--] engagements "9) Cytokeratin [--] and cytokeratin [--] are crucial components for the development and maintenance of healthy skin. The proper distribution of cytokeratin [--] in the basal layer is vital as it provides structural support to the cells ensuring their shape and function are maintained" [X Link](https://x.com/healthspanmed/status/1825971353545269543) 2024-08-20T19:01Z [----] followers, [--] engagements "10) Moreover cytokeratin [--] is thought to regulate the process of mitosis which is crucial in the replacement of the skin cells that are shed from the surface of the skin" [X Link](https://x.com/healthspanmed/status/1825971376207048998) 2024-08-20T19:01Z [----] followers, [--] engagements "11) Researchers found that in the skin samples from people who had used the rapamycin cream the staining for cytokeratin 5/6 was more focused in the basal layer of the skin. Skin samples from the placebo cream showed staining for cytokeratin 5/6 in a different layer of the skin" [X Link](https://x.com/healthspanmed/status/1825971407135846640) 2024-08-20T19:01Z [----] followers, [--] engagements "The National Institute on Aging Interventions Testing Program (ITP) was designed to be the most exhaustive testing framework and system to evaluate whether longevity molecules extend longevity in mice and understand the underlying mechanisms leading to those benefits. The ITP involves the collaboration of three research labs running experiments in parallel. These labs conducted evaluations on a selection of promising longevity molecules including rapamycin metformin nicotinamide riboside and the SGLT-2 inhibitor canagliflozin among others. At the end of the study only five of the molecules" [X Link](https://x.com/healthspanmed/status/1826771352684286246) 2024-08-23T00:00Z [----] followers, [---] engagements "1. Regulating Glucose SpikesReducing ROS Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine. By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose. In studies of diabetes patients taking acarbose we have observed an absolute decrease of 0.7% in HbA1c levels which translates to approximately a 10% reduction in typical HbA1c values for diabetes patients. This reduction in blood glucose levels has a profound" [X Link](https://x.com/healthspanmed/status/1826771376088514859) 2024-08-23T00:00Z [----] followers, [--] engagements "In @michaelamrds low-protein vs high-protein investigation they had an additional two groups which consumed the same low/high protein diets but with the addition of resistance-type exercise" [X Link](https://x.com/healthspanmed/status/1827783241459241287) 2024-08-25T19:00Z [----] followers, [--] engagements "Notably the high-protein diet when combined with exercise training resulted in greater gains in lean mass with no impairments to glycaemic control or the accumulation of fat mass observed in the non-exercise high-protein group" [X Link](https://x.com/healthspanmed/status/1827783264213561450) 2024-08-25T19:01Z [----] followers, [--] engagements "Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z" [X Link](https://x.com/healthspanmed/status/1827858539542675545) 2024-08-26T00:00Z [----] followers, [---] engagements "Healthspan's Dr. Elana Miller highlights the mechanisms through which acarbose promotes healthspan emphasizing its role in metabolic regulation. She also explores the synergistic benefits of combining acarbose with rapamycin noting how their complementary actions enhance longevity and overall health outcomes. https://www.youtube.com/watchv=VyK_Gly4IS0 https://www.youtube.com/watchv=VyK_Gly4IS0" [X Link](https://x.com/healthspanmed/status/1831271012517704008) 2024-09-04T10:00Z [----] followers, [---] engagements "As we age our bodies experience anabolic resistancea diminished ability to build muscle even with regular exercise and protein intake. A closer look at the serum factors in young blood versus older samples reveals a compelling story. In this weeks research review we explore the mechanisms behind this shift highlighting one key player: the hormone oxytocin. While commonly known for its role in social bonding emerging research shows that oxytocin also plays a significant role in muscle maintenance and fat metabolism. Its natural decline with age may contribute to sarcopenic obesity. We will" [X Link](https://x.com/healthspanmed/status/1833884040921006336) 2024-09-11T15:03Z [----] followers, [---] engagements "New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/" [X Link](https://x.com/healthspanmed/status/1834216017515688228) 2024-09-12T13:02Z [----] followers, [---] engagements "Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel" [X Link](https://x.com/healthspanmed/status/1841191402790908213) 2024-10-01T19:00Z [----] followers, [---] engagements "Rapamycin seems to increase collagen VII in the basement layer of the skin The mechanism by which rapamycin increases collagen VII is thought that rapamycin's effects on increasing autophagy and proper vesicle trafficking. Learn more: https://gethealthspan.com/blog/articles/inhibiting-skin-senescence-with-topical-rapamycin-sirolimus-for-anti-aging-skincare/40o2ogqdwaekuxak96h3iy/ https://gethealthspan.com/blog/articles/inhibiting-skin-senescence-with-topical-rapamycin-sirolimus-for-anti-aging-skincare/40o2ogqdwaekuxak96h3iy/" [X Link](https://x.com/healthspanmed/status/1849601787407564930) 2024-10-25T00:00Z [----] followers, [---] engagements "Is menopause delay possible Researchers at Columbia University are studying rapamycins role in conserving womens eggs and slowing reproductive aging. mTOR plays a key role in regulating egg release and by inhibiting mTOR rapamycin may help delay menopause and extend reproductive health. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z" [X Link](https://x.com/healthspanmed/status/1851413743508627668) 2024-10-30T00:00Z [----] followers, [---] engagements "New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity" [X Link](https://x.com/healthspanmed/status/1853890094450856279) 2024-11-05T20:00Z [----] followers, [---] engagements "Can a high-protein diet backfire without exercise Recent evidence from the world-leading @LammingLab at the University of Wisconsin-Madison shows that a high-protein diet without any exercise can cause insulin resistance and an accumulation of white adipose tissue in as little as [--] weeks even when matched for caloric intake. @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity" [X Link](https://x.com/healthspanmed/status/1854811110513504380) 2024-11-08T09:00Z [----] followers, [---] engagements "We're excited to share a new chapter in our journey to combat agingthis time for our four-legged family members. Today we're proud to announce the launch of Petspan the first telemedicine clinic dedicated to extending the healthy lifespan of our pets using the same rigorous science that has guided our work with Healthspan. As many of you know our mission at Healthspan has always been to leverage the latest advancements in longevity science to help our patients regain control over the aging process and combat age-related chronic diseases. With Petspan were bringing that same commitment to" [X Link](https://x.com/healthspanmed/status/1860262015371214867) 2024-11-23T10:00Z [----] followers, [---] engagements "🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR" [X Link](https://x.com/healthspanmed/status/1865890876687560936) 2024-12-08T22:47Z [----] followers, [---] engagements "🚨 🚨 New Research Review: SGLT2 Inhibitors: The Unexpected Longevity Molecules and Their Mechanistic Impact on Aging Science by @RNMarshallPhD https://hspan.io/ksmRdk https://hspan.io/ksmRdk" [X Link](https://x.com/healthspanmed/status/1875933243889144032) 2025-01-05T15:51Z [----] followers, [---] engagements "The Longevity Blueprint Connecting mTOR and Mitochondria: The Novel Synergy Between Rapamycin and Urolithin A - https://mailchi.mp/gethealthspan/glymphatic-system-12724604 https://mailchi.mp/gethealthspan/glymphatic-system-12724604" [X Link](https://x.com/healthspanmed/status/1878480692775960576) 2025-01-12T16:34Z [----] followers, [---] engagements "Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z" [X Link](https://x.com/healthspanmed/status/1882518670657908916) 2025-01-23T20:00Z [----] followers, [---] engagements "We're excited to share a new chapter in our journey to combat agingthis time for our four-legged family members. Today we're proud to announce the launch of Petspan the first telemedicine clinic dedicated to extending the healthy lifespan of our pets using the same rigorous science that has guided our work with Healthspan. As many of you know our mission at Healthspan has always been to leverage the latest advancements in longevity science to help our patients regain control over the aging process and combat age-related chronic diseases. With Petspan were bringing that same commitment to" [X Link](https://x.com/healthspanmed/status/1883318943689175402) 2025-01-26T01:00Z [----] followers, [---] engagements "🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR" [X Link](https://x.com/healthspanmed/status/1887501522621374673) 2025-02-06T14:00Z [----] followers, [---] engagements "🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR" [X Link](https://x.com/healthspanmed/status/1893752712053047564) 2025-02-23T20:00Z [----] followers, [---] engagements "🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR" [X Link](https://x.com/healthspanmed/status/1905334019337892192) 2025-03-27T19:00Z [----] followers, [---] engagements "@mamie_tenney @NickLuto @bryan_johnson Petspan focuses on rapamycin protocols for pets. You can learn more about it here: https://www.petspan.com/ https://www.petspan.com/" [X Link](https://x.com/healthspanmed/status/1907807483487191103) 2025-04-03T14:48Z [----] followers, [--] engagements "For over a century scientists believed that amyloid plaques in the brain were the root cause of Alzheimers disease. But new researchincluding work from Dr. Francisco Gonzalez-Limasuggests that problems with blood flow and mitochondrial energy production may actually occur before plaque buildup and could be what initiates the disease in the first place. Last Sunday Healthspans lead scientist Dr. Rich LaFountain explored this emerging framework by reviewing decades of research from the Gonzalez-Lima Labalongside insights from vascular neuroscientist Dr. Jack de la Torre. Their findings point to" [X Link](https://x.com/healthspanmed/status/1910588633016656139) 2025-04-11T07:00Z [----] followers, [---] engagements "New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity" [X Link](https://x.com/healthspanmed/status/1916281141344231560) 2025-04-27T00:00Z [----] followers, [---] engagements "🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: [--] https://hspan.io/l9d6jR https://hspan.io/l9d6jR" [X Link](https://x.com/healthspanmed/status/1916643541927030993) 2025-04-28T00:00Z [----] followers, [---] engagements "As researchers evaluating mitochondrial function begins with two key parameters: the ability of a compound to boost ATP production and its capacity to reduce oxidative stress. These metrics are fundamental to assessing mitochondrial efficiencyessential for sustaining cellular energy and minimizing the oxidative damage that accelerates aging. Compounds that achieve these outcomes hold potential as geroprotective interventions particularly in aging tissues where mitochondrial decline is most evident. This week we apply this framework to Urolithin A a gut-derived metabolite recognized for its" [X Link](https://x.com/healthspanmed/status/1918017585733571050) 2025-05-01T19:00Z [----] followers, [---] engagements "🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2" [X Link](https://x.com/healthspanmed/status/1932860511424762126) 2025-06-11T18:00Z [----] followers, [---] engagements "🧬 A mitochondrial enzymeusually locked deep inside our cellshas now been found circulating in the blood of long COVID patients. And it may hold the key to understanding fatigue brain fog and post-viral exhaustion. The enzyme is called PRDX3 and its doing more than signaling damageit may be pointing us to the heart of long COVID: mitochondrial failure. 👇 Heres what the latest research revealsand how it might reshape recovery strategies: 🔍 The Mystery of Long COVID Millions still suffer from lingering symptoms after COVIDdebilitating fatigue cognitive slowing dizziness and shortness of" [X Link](https://x.com/healthspanmed/status/1933322557257887836) 2025-06-13T00:36Z [----] followers, [---] engagements "🧠 What if Alzheimers isnt caused by plaques at allbut by an energy crisis inside your brain cells When you dig into the research of Dr. Francisco Gonzalez-Lima and Dr. Jack de la Torre on mitochondrial dysfunction in Alzheimers diseaseand the potential of methylene blue to restore neuronal energyyou begin to see a radically different framing of the disease. If you accept the premise that one of the primary drivers of AD is an energy shortfall within neurons the question becomes: where is that deficit happening The answer Gonzalez-Lima argues is almost certainly the mitochondria. His work" [X Link](https://x.com/healthspanmed/status/1936861752232378383) 2025-06-22T19:00Z [----] followers, [---] engagements "🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2" [X Link](https://x.com/healthspanmed/status/1938885089305432342) 2025-06-28T09:00Z [----] followers, [---] engagements "🧬 Is aging just wear-and-tear or is it a built-in flaw in our biological software Dr. Joo Pedro de Magalhes @jpsenescence proposes an interesting perspective on the theoretical underpinning of aging: our DNA is the hardware while the epigenomethe chemical tags that turn genes on or offacts as software. Over time this software may become maladaptive driving the aging process rather than merely reacting to damage. Heres what you need to know. 👇 🔍 The Research In a his paper Ageing as a software design flaw Dr. de Magalhes compares the epigenome to computer software that executes genetic" [X Link](https://x.com/healthspanmed/status/1941285905249321151) 2025-07-05T00:00Z [----] followers, [---] engagements "What Does It Really Mean to Be Metabolically Flexible In this week's episode of Beyond Healthspan we break down one of the most influential papers in exercise physiology: Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate Fat and Carbohydrate Oxidation Responses to Exercise by @doctorinigo and Dr. George Brooks. We explore: 🔬 What metabolic flexibility actually isand how to measure it 🧬 Why lactate isnt just a waste product but a key fuel and signal ⚡ How professional athletes use fat and carbs differentlyand what we can learn from it 🧠 How mitochondrial health" [X Link](https://x.com/healthspanmed/status/1941572799908413699) 2025-07-05T19:00Z [----] followers, [---] engagements "🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2" [X Link](https://x.com/healthspanmed/status/1943022395457179946) 2025-07-09T19:00Z [----] followers, [---] engagements "💊 Enter Rapamycin: Resetting the Fullness Signal If mTOR overactivation is jamming the brains ability to hear leptin could inhibiting mTOR restore the signal Thats exactly what researchers tested in a recent series of experiments using rapamycin a well-known mTOR inhibitor. Rapamycin has long been studied for its ability to extend lifespan but here it was used to address something very different: reversing leptin resistance in the hypothalamus" [X Link](https://x.com/healthspanmed/status/1943384807645548734) 2025-07-10T19:00Z [----] followers, [--] engagements Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing
@healthspanmed Healthspan
Healthspan posts on X about health, enzyme, ros, science the most. They currently have [-----] followers and [---] posts still getting attention that total [-----] engagements in the last [--] hours.
Engagements: [-----] #
- [--] Week [------] +1,057%
- [--] Month [------] +232%
- [--] Months [------] +999%
- [--] Year [------] +405%
Mentions: [--] #
Followers: [-----] #
- [--] Week [-----] +0.42%
- [--] Month [-----] +1.10%
- [--] Months [-----] +9.90%
- [--] Year [-----] +17%
CreatorRank: [---------] #
Social Influence
Social category influence finance technology brands
Social topic influence health, enzyme, ros, science, accumulation, brain, eggs, university of, has been, longevity
Top assets mentioned Enzyme (MLN) Oxygen (OXY) Serum (SRM) Urolithin A (URO)
Top Social Posts
Top posts by engagements in the last [--] hours
"@Blagosklonny If you need any help with graphics for the article our design team can help"
X Link 2023-06-29T23:57Z [----] followers, [---] engagements
"1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging. The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions. Here's how it works 👇"
X Link 2023-07-09T18:10Z [----] followers, [----] engagements
"2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function. This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves leading to the accumulation of damage over time"
X Link 2023-07-09T18:10Z [----] followers, [---] engagements
"16. The fact that senescent cells cannot replicate impacts their size activity and pathology. When a healthy cell is exposed to growth stimuli it can balance out its growth by dividing. Senescent cells cannot share the burden of growth with other cells by simply dividing"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"17. Instead when senescent cells are exposed to growth signals they: [--]. Become very large [--]. Hyper-mitogenic (causing hyperplasia) [--]. Release molecules that stimulate the proliferation of adjacent cells and are resistant to programmed cell death"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"20. As we age the proportion of senescent cells increases as they become harder to remove. This has tremendous implications for the acceleration of aging. Seeing senescence as a state of continuous growth without cell division helps us understand systemic aging"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"21. Many people associate age-related diseases with loss of cellular function. Cellular senescence is often perceived as a manifestation of functional decline or wear-and-tear leading to accumulated cellular damage that exceeds the body's self-repair mechanisms. It's not"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"39. Lowering mTOR activity represents a broadly applicable treatment to reduce cellular hyper-functions and the following decline of tissue function. Rapamycin is a molecule known to inhibit mTOR activity"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"40. By suppressing the mTOR pathway rapamycin reduces the release of detrimental molecules from senescent cells. This not only safeguards neighboring tissues from potential harm but also encourages the elimination of these aging cells through autophagy"
X Link 2023-07-09T18:10Z [----] followers, [--] engagements
"1. Rapamycin paradoxically suppresses immune function when taken daily at high doses. When taken cyclically at low doses it enhances it. How do mTOR inhibitors like rapamycin may enhance immune function The research of @MannickJoan is critical to understanding how. LG 🧵👇"
X Link 2023-08-24T13:00Z [----] followers, [---] engagements
"1) While time-restricted eating (eating within an 8-10 hour window each day) is known to improve organ systems the genomic changes have largely been unknown. A study in @Cell_Metabolism sheds light on the underlying genomic changes. Here's how: 🧵👇"
X Link 2023-08-25T19:00Z [----] followers, [---] engagements
"2) Background: Time-restricted feeding has been shown to have a variety of health benefits including improved exercise capacity sleep blood pressure and gut health as well as reduced cancer risk and neurodegenerative disease severity"
X Link 2023-08-25T19:00Z [----] followers, [--] engagements
"3) The potential health benefits of TRF may be due to its effects on pathways like mTOR AMPK Sirtuins and insulin/IGF1 signaling which regulate nutrient intake processing and gene expression in the body"
X Link 2023-08-25T19:00Z [----] followers, [--] engagements
"1. Recent research has begun to demonstrate that rapamycin may have significant benefits for women's health in: 1) preserving ovarian function 2) extending fertility 3) delaying menopause How does rapamycin work to promote ovarian function Here's the latest research 👇🧵"
X Link 2023-08-26T09:00Z [----] followers, [---] engagements
"8. There have been several attempts to restore and maintain oocyte quantity and quality with nutraceutical approaches such as Resveratrol Coenzyme Q10 Vitamin C and NMN to target the increased mitochondrial ROS & DNA damage associated with oocyte aging with limited effects"
X Link 2023-08-26T09:00Z [----] followers, [--] engagements
"9. Of these mechanisms mTOR has an often overlooked role in the activation and dysregulation of ovarian growth signaling of primordial follicles. Primordial follicles are the earliest stage of ovarian follicle development and represent the reserve of immature eggs (oocytes)"
X Link 2023-08-26T09:00Z [----] followers, [--] engagements
"19. Unlocking the potential of rapamycin as a therapeutic intervention to prevent menopause and enhance ovarian health in women has become an increasingly popular avenue of research for longevity researchers. Let's dive into the latest research"
X Link 2023-08-26T09:00Z [----] followers, [--] engagements
"20. Rapamycin and Fertility Recent studies have shown that rapamycin can improve ovarian function and increase the number of eggs produced by the ovaries. In one study female mice treated with rapamycin had a significantly greater egg quality"
X Link 2023-08-26T09:00Z [----] followers, [--] engagements
"Topical Rapamycin reduces the occurrence of solar elastosis and disorganized collagen fibers in the skin. By promoting autophagy rapamycin enhances the health of the skin layer by increasing the clearance of damaged cellular components. Learn more:"
X Link 2023-08-27T00:00Z [----] followers, [---] engagements
"17. Chronic overactivation of mTOR is at the foundation of many age-related diseases. As we get older mTOR may stay active all the timeopening the door to out-of-control cell growth. It is a driver of toxic cellular hyperactivity leading to the decline of healthy tissue"
X Link 2023-09-01T00:00Z [----] followers, [--] engagements
"1) While time-restricted eating (eating within an 8-10 hour window each day) is known to improve organ systems the genomic changes have largely been unknown. A study in @Cell_Metabolism sheds light on the underlying genomic changes. Here's how: 🧵👇"
X Link 2023-09-09T00:00Z [----] followers, [---] engagements
"Our founder @dantawfik was on the Wise Athletes podcast where they covered a number of longevity topics: [--]. The importance of @Blagosklonny's theory of hyperfunction. [--]. mTOR driven-aging & senescence. [--]. Rapamycin [--]. Metabolic pathways as levers"
X Link 2023-09-22T00:00Z [----] followers, [---] engagements
"30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction"
X Link 2023-10-13T00:00Z [----] followers, [--] engagements
"31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability"
X Link 2023-10-13T00:00Z [----] followers, [--] engagements
"Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:"
X Link 2023-10-14T00:00Z [----] followers, [----] engagements
"While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:"
X Link 2023-10-14T09:00Z [----] followers, [---] engagements
"12. Upon identifying these patterns TLR4 instigates an inflammatory cascademarshaling the immune system to counteract infections and manage tissue damage. This series of molecular events culminates in activating specific pro-inflammatory transcription factors"
X Link 2023-10-14T19:00Z [----] followers, [--] engagements
"13. When activated these transcription factors boost production of pro-inflammatory agents. These include cytokines like interleukin-1 interleukin-6 and tumor necrosis factor-alpha along with other molecules essential for the inflammatory response"
X Link 2023-10-14T19:00Z [----] followers, [--] engagements
"Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging"
X Link 2023-10-17T14:00Z [----] followers, [---] engagements
"1. Rapamycin paradoxically suppresses immune function when taken daily at high doses. When taken cyclically at low doses it enhances it. How do mTOR inhibitors like rapamycin may enhance immune function The research of @MannickJoan is critical to understanding how. LG 🧵👇"
X Link 2023-10-27T00:00Z [----] followers, [----] engagements
"The fermentation leads to an increase in the production of short-chain fatty acids (SCFAs) and increases the abundance of certain types of beneficial bacteria in the gut such as Bifidobacterium and Lactobacillus"
X Link 2023-10-30T00:00Z [----] followers, [--] engagements
"Short-chain fatty acids particularly butyrate were highly correlated with longer lifespans in the ITP. SCFAs may play a critical role in extending longevity and may also produce other signaling molecules that have been associated with longevity benefits"
X Link 2023-10-30T00:00Z [----] followers, [--] engagements
"2. Chronic inflammation lies at the core of numerous debilitating diseases from autoimmune disorders to neurodegenerative conditions. While acute inflammation serves a protective purpose chronic inflammation leads to tissue dysfunction and the acceleration of aging"
X Link 2023-10-30T08:00Z [----] followers, [--] engagements
"3. In individuals with chronic inflammatory ailments there's a relentless hyperactivity of the immune system. Inflammatory cells discharge signaling molecules known as cytokines. These cytokines play a pivotal role in sustaining an inflammatory response"
X Link 2023-10-30T08:00Z [----] followers, [--] engagements
"While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:"
X Link 2023-10-30T19:00Z [----] followers, [---] engagements
"1. Photodamage Photodamage is a result of prolonged exposure to UV radiation which can lead to the breakdown of collagen and elastin fibers resulting in wrinkles dyspigmentation and dull-appearing skin"
X Link 2023-10-31T14:00Z [----] followers, [--] engagements
"2. Dermal Atrophy Dermal atrophy or skin "thinning" is caused by a reduction in the underlying tissue and can result in a loss of firmness and elasticity. Impaired barrier function causes dryness flakiness and a weakened skin barrier making the skin susceptible to damage"
X Link 2023-10-31T14:00Z [----] followers, [--] engagements
"24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and"
X Link 2023-11-01T10:00Z [----] followers, [--] engagements
"25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts"
X Link 2023-11-01T10:00Z [----] followers, [--] engagements
"While data shows GLP-1 weight loss drugs have positive impacts on reducing body fat many have concerns about their impact on lean muscle mass. @RNMarshallPhD analyzes the latest research on the potential adverse effects of these weight loss drugs:"
X Link 2023-11-27T01:00Z [----] followers, [---] engagements
"30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction"
X Link 2023-11-27T20:00Z [----] followers, [--] engagements
"31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability"
X Link 2023-11-27T20:00Z [----] followers, [--] engagements
"Topical Rapamycin reduces the occurrence of solar elastosis and disorganized collagen fibers in the skin. By promoting autophagy rapamycin enhances the health of the skin layer by increasing the clearance of damaged cellular components. Learn more:"
X Link 2023-12-03T20:00Z [----] followers, [---] engagements
"24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and"
X Link 2023-12-05T15:00Z [----] followers, [--] engagements
"25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts"
X Link 2023-12-05T15:00Z [----] followers, [--] engagements
"Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:"
X Link 2023-12-06T20:00Z [----] followers, [---] engagements
"28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging"
X Link 2023-12-08T01:00Z [----] followers, [--] engagements
"29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How"
X Link 2023-12-08T01:00Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2023-12-08T20:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2023-12-08T20:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2023-12-08T20:00Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2023-12-11T01:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2023-12-11T01:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2023-12-11T01:00Z [----] followers, [--] engagements
"Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels"
X Link 2023-12-11T01:00Z [----] followers, [--] engagements
"Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues"
X Link 2023-12-11T01:00Z [----] followers, [--] engagements
"18. Senescent cells are also hyper-inflammatory. They excrete a witch's brew of inflammatory molecules and growth factors known as the senescence-associated secretory phenotype (SASP) The SASP is a complex set of signaling molecules that damage and stimulate nearby cell growth"
X Link 2023-12-26T01:00Z [--] followers, [--] engagements
"19. As a result senescent cells are effectively "stuck" in a state of high activity with both the gas pedal and the brakes pressed to the floor. The only way for senescent cells to be cleared is through the action of nearby immune cells which can recognize and remove them"
X Link 2023-12-26T01:00Z [----] followers, [--] engagements
"28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging"
X Link 2023-12-26T01:00Z [--] followers, [--] engagements
"29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How"
X Link 2023-12-26T01:00Z [----] followers, [--] engagements
"30. Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction"
X Link 2023-12-26T01:00Z [----] followers, [--] engagements
"31. Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability"
X Link 2023-12-26T01:00Z [----] followers, [--] engagements
"1. People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇"
X Link 2023-12-26T15:00Z [----] followers, [----] engagements
"Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels"
X Link 2023-12-27T11:00Z [----] followers, [--] engagements
"Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues"
X Link 2023-12-27T11:00Z [----] followers, [--] engagements
"Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Watch our full breakdown about the potential use of rapamycin as an Alzheimer's prophylactic:"
X Link 2024-01-25T19:53Z [--] followers, [---] engagements
"28. The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging"
X Link 2024-01-31T01:00Z [----] followers, [--] engagements
"29. These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How"
X Link 2024-01-31T01:00Z [----] followers, [--] engagements
"1. People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇"
X Link 2024-01-31T20:00Z [----] followers, [---] engagements
"3. Muscles are composed of two main types of fibers: slow-twitch type I fibers and fast-twitch type II fibers. Type II muscle fibers are like sprinters offering high-energy bursts Type I fibers resemble marathon runners known for their endurance and rich mitochondrial content"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"4. As we age our immune function declines accompanied by increased pro-inflammatory agents (IL-1 IL-6 TNF-). This inflammation sets off a cascade of events: - impaired mitochondria that produce less energy - More reactive oxygen species (ROS) that damage mitochondria"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"20. As we age mTOR may stay active all the timeopening the door to out-of-control cell growth. This means we are not seeing the level of clearance of damaged mitochondria and damaged cellular proteins. With damaged mitochondria you have less efficient glucose metabolism"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"21. Mitochondrial dysfunction is another link between cognitive decline and sarcopenia. Mitochondrial dysfunction in aging is partly due to accumulated damage from mitochondrial DNA mutations and Reactive Oxygen Species (ROS) which cause cellular molecular damage"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"35. Blocking trans-signaling can halt disease progression pointing towards its critical role in inflammatory pathologies and inflamm-aging in the CNS. So we know that IL-6 signaling is a culprit in a number of chronic inflammatory conditions. This is important"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"36. Here's where modern lifestyles come into the picture. Obese individuals often have increased levels of IL-6R and the enzyme ADAM17. The ADAM17 enzyme is responsible for creating that soluble IL-6 receptor we talked about. It enables the more harmful trans-signaling"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"41. When muscles remain dormant and inactive they tend to limit their endocrine capabilities. This means that less myokines are released. This shift leans towards promoting inflammation which in the long run can escalate the risk of dementia"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"42. What does this mean for the brain Myokines have the potential to relay the benefits of physical activity to the brain potentially promoting neurogenesis and combating neurodegenerative diseases. However they must first breach the formidable blood-brain barrier"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"72. Are the deficits in brain insulin directly tied to the spike in peripheral insulin levels especially those accentuated by a decline in skeletal muscle mass Or could there be other factors hidden threads we've yet to discover that contribute to this delicate balance"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"73. Alzheimer's Disease provides a compelling backdrop for this exploration. The myriad of mechanisms linking peripheral hyperinsulinemia to AD creates a maze of biological interactions. The intricate interaction between the insulin-degrading enzyme (IDE) and A stands out"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"74. Insulin-degrading enzyme (IDE) is an enzyme that's responsible for degrading insulin once it has fulfilled its role. But beyond insulin IDE is also known to degrade other small peptides including A. This dual role makes an important enzyme for cognitive health"
X Link 2024-02-01T01:08Z [----] followers, [--] engagements
"87. 🚨 Mechanism 4: Mitochondrial Dysfunction The mitochondrion crucial for skeletal muscle energy conducts key processes like ATP synthesis through oxidative phosphorylation apoptosis regulation and ROS production control If one process falters it risks system dysfunction"
X Link 2024-02-01T01:09Z [----] followers, [--] engagements
"88. Reactive oxygen and nitrogen species (RONS) are crucial in cellular signaling within muscle tissues. While normally beneficial excessive RONS production leads to oxidative stress damaging cells and their structures"
X Link 2024-02-01T01:09Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2024-02-03T10:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2024-02-03T10:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2024-02-03T10:00Z [----] followers, [--] engagements
"31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"35. Blocking trans-signaling can halt disease progression pointing towards its critical role in inflammatory pathologies and inflamm-aging in the CNS. So we know that IL-6 signaling is a culprit in a number of chronic inflammatory conditions. This is important"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"36. Here's where modern lifestyles come into the picture. Obese individuals often have increased levels of IL-6R and the enzyme ADAM17. The ADAM17 enzyme is responsible for creating that soluble IL-6 receptor we talked about. It enables the more harmful trans-signaling"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"41. When muscles remain dormant and inactive they tend to limit their endocrine capabilities. This means that less myokines are released. This shift leans towards promoting inflammation which in the long run can escalate the risk of dementia"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"42. What does this mean for the brain Myokines have the potential to relay the benefits of physical activity to the brain potentially promoting neurogenesis and combating neurodegenerative diseases. However they must first breach the formidable blood-brain barrier"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point"
X Link 2024-02-08T14:00Z [----] followers, [--] engagements
"72. Are the deficits in brain insulin directly tied to the spike in peripheral insulin levels especially those accentuated by a decline in skeletal muscle mass Or could there be other factors hidden threads we've yet to discover that contribute to this delicate balance"
X Link 2024-02-08T14:01Z [----] followers, [--] engagements
"73. Alzheimer's Disease provides a compelling backdrop for this exploration. The myriad of mechanisms linking peripheral hyperinsulinemia to AD creates a maze of biological interactions. The intricate interaction between the insulin-degrading enzyme (IDE) and A stands out"
X Link 2024-02-08T14:01Z [----] followers, [--] engagements
"74. Insulin-degrading enzyme (IDE) is an enzyme that's responsible for degrading insulin once it has fulfilled its role. But beyond insulin IDE is also known to degrade other small peptides including A. This dual role makes an important enzyme for cognitive health"
X Link 2024-02-08T14:01Z [----] followers, [--] engagements
"31. This ongoing loop can meddle with normal brain functions such as memory encoding and exacerbate the damaging effects of toxic substances like A. This cycle of inflammation and damage could be a driving force behind the deterioration of our cognitive faculties"
X Link 2024-02-15T14:00Z [----] followers, [--] engagements
"32. IL-6 is an important cytokine in understanding the muscle brain connection. IL-6 is a bit of a paradox. When emitted by our muscle fibers during contraction it can act as an anti-inflammatory agent. But it is also harmful in other contexts"
X Link 2024-02-15T14:00Z [----] followers, [--] engagements
"49. The value of BDNF isn't just theoretical. In community-dwelling older women low plasma BDNF levels were linked to reduced cognitive abilities. Lower BDNF concentrations indicated an increased mortality risk over the following five years"
X Link 2024-02-15T14:00Z [----] followers, [--] engagements
"50. Delving into the realm of Alzheimer's Disease (AD) a stark contrast emerges: Peripheral BDNF levels in AD patients trail significantly behind those of their non-AD counterparts. Why might this be significant Muscular contraction becomes a focal point"
X Link 2024-02-15T14:00Z [----] followers, [--] engagements
"58. Insulin resistance has emerged as a serious risk factor potentially steering the ship towards cognitive decline. This suggests that our muscles and their role in glucose management are inextricably linked to our physical well-being and cognitive health"
X Link 2024-02-15T14:01Z [----] followers, [--] engagements
"59. Aging often leads to a detrimental cycle of impaired glucose tolerance and insulin resistance which is linked to changes in brain function and regional cerebral blood flow in older individuals even without cognitive dysfunction. The brain relies on glucose"
X Link 2024-02-15T14:01Z [----] followers, [--] engagements
"61. With aging insulin resistance worsens. Insulin and glucose crossing the blood-brain barrier (BBB) affect the brain by remodeling synapses influencing neurotransmitter expression and improving glucose metabolism in certain brain areas"
X Link 2024-02-15T14:01Z [----] followers, [--] engagements
"62. When there's an excess of insulin in the blood it damages this system by reducing the number of insulin receptors in the blood brain barrier. Think of it as closing the gates to the brain which then restricts the flow of insulin inside. The outcome"
X Link 2024-02-15T14:01Z [----] followers, [--] engagements
"25. Conditions like Fibromyalgia may be linked to chronic glial cell activation and neuroinflammation. The similarity in symptoms between Fibromyalgia and cytokine-induced sickness suggests LDN's anti-inflammatory impact might stem from its effect on microglial activation"
X Link 2024-02-16T09:00Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2024-02-17T10:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2024-02-17T10:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2024-02-17T10:00Z [----] followers, [--] engagements
"Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels"
X Link 2024-02-17T10:00Z [----] followers, [--] engagements
"Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues"
X Link 2024-02-17T10:00Z [----] followers, [--] engagements
"Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic:"
X Link 2024-02-17T20:00Z [----] followers, [---] engagements
"@Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging. The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions. Here's how it works 👇"
X Link 2024-04-28T19:00Z [----] followers, [---] engagements
"Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function. This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves leading to the accumulation of damage over time"
X Link 2024-04-28T19:00Z [----] followers, [--] engagements
"It is the hyperfunction of the smooth muscle cells that leads to the loss of function of the tissue. Cellular hyperfunction hyperplasia and hypertrophy of smooth muscle cells lead to atherosclerosis and hypertension ultimately leading to strokes and myocardial function"
X Link 2024-04-28T19:01Z [----] followers, [--] engagements
"@Blagosklonny connects nearly every age-related disease to hyperactivity rather than loss of cellular output. Here are some more examples. Osteoporosis 🚨 In osteoporosis osteoclasts become outsized and overactive leading to the resorption of bone tissue"
X Link 2024-04-28T19:01Z [----] followers, [--] engagements
"The overproduction of keratinocytes leads to an excess of keratin which causes the skin to become thicker and less elastic. Reduced elasticity can make the skin more prone to developing wrinkles and fine lines. A case of hyperfunctions accelerating visible signs of aging"
X Link 2024-04-28T19:01Z [----] followers, [--] engagements
"These are just a few examples of cellular hyper-functions damaging the health of the tissue it comprises. With this understanding of hyperfunctionality it would be most effective to halt this initial hyperfunction before there is a terminal loss of tissue function. How"
X Link 2024-04-28T19:01Z [----] followers, [--] engagements
"By suppressing the mTOR pathway rapamycin reduces the release of detrimental molecules from senescent cells. This not only safeguards neighboring tissues from potential harm but also encourages the elimination of these aging cells through autophagy"
X Link 2024-04-28T19:02Z [----] followers, [--] engagements
"Rapamycin plays a crucial role in decelerating the accumulation of cellular damage and reducing the overall population of senescent cells thereby mitigating their harmful effects on our bodies"
X Link 2024-04-28T19:02Z [----] followers, [--] engagements
"Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel"
X Link 2024-05-01T20:30Z [----] followers, [---] engagements
"New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/"
X Link 2024-05-04T00:00Z [----] followers, [---] engagements
"24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and"
X Link 2024-05-07T19:01Z [----] followers, [---] engagements
"25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts"
X Link 2024-05-07T19:01Z [----] followers, [--] engagements
"Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel"
X Link 2024-05-09T13:00Z [----] followers, [---] engagements
"1) A recent study investigated the potential of rapamycin to slow down skin senescence when applied topically. The results were striking. Markers of skin senescence dropped by 50%. What are the molecular changes to the skin after rapamycin treatment Let's dive in 🧵👇"
X Link 2024-05-12T00:00Z [----] followers, [---] engagements
"2) Mechanism 1: Rapamycin Reduced P16 Derived Inflammation The researchers focused on a protein called p16INK4A (p16) which is involved in regulating the cell cycle and senescence. P16 is expressed at high levels in the skin and has been linked to skin aging"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"3) In addition to its role in senescence p16 is involved in regulating inflammation in the skin. Inflammation is a key factor in skin aging and high levels of inflammation in the skin have been associated with the development of wrinkles and other signs of aging"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"5) Mechanism 2: Topical Rapamycin Reduces Solar Elastosis Researchers also assessed the levels of a skin condition known as solar elastosis. This condition is commonly seen in individuals who have experienced chronic sun exposure particularly in the face neck and hands"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"6) Solar elastosis occurs when abnormal elastic fibers accumulate in the skin resulting in a thickened and yellowed appearance. It is a key feature of actinic keratoses which are pre-cancerous skin lesions caused by sun damage"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"10) Moreover cytokeratin [--] is thought to regulate the process of mitosis which is crucial in the replacement of the skin cells that are shed from the surface of the skin"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"11) Researchers found that in the skin samples from people who had used the rapamycin cream the staining for cytokeratin 5/6 was more focused in the basal layer of the skin. Skin samples from the placebo cream showed staining for cytokeratin 5/6 in a different layer of the skin"
X Link 2024-05-12T00:00Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2024-05-13T19:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2024-05-13T19:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2024-05-13T19:00Z [----] followers, [--] engagements
"Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels"
X Link 2024-05-13T19:00Z [----] followers, [--] engagements
"Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues"
X Link 2024-05-13T19:00Z [----] followers, [--] engagements
"Here are some ways to pump the hyperfunction breaks: [--]. Caloric Restriction Our cells pump the brakes when there aren't enough nutrients around. If there isn't gas available the car won't move. In the lab and in humans this can be accomplished with caloric restriction"
X Link 2024-05-24T19:01Z [----] followers, [--] engagements
"Scientists have long known that for a cell to enter a growth phase it requires sufficient energy to fuel growth. What happens when a cell is faced with an energy deficit Autophagy 💪😎 Autophagy allows cells to survive under conditions of low energy availability"
X Link 2024-05-24T19:01Z [----] followers, [--] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2024-05-25T19:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2024-05-25T19:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2024-05-25T19:00Z [----] followers, [--] engagements
"Rapamycin when given prophylactically to 2-month-old 3xTg-AD mice throughout their life induces autophagy and significantly reduces plaques tangles and cognitive deficits. Learn more about the potential use of rapamycin as an Alzheimer's prophylactic: https://gethealthspan.com/blog/articles/mtor-signaling-neurodegenerative-disorders-therapeutic-potential-rapamycin/5rzr6cmf1xclamddflgp2k/ https://gethealthspan.com/blog/articles/mtor-signaling-neurodegenerative-disorders-therapeutic-potential-rapamycin/5rzr6cmf1xclamddflgp2k/"
X Link 2024-08-06T19:00Z [----] followers, [---] engagements
"There seems to be something about how acarbose lowers postprandial glucose levelsthrough its effects on gut microbiotawhich makes it a powerful healthspan-promoting molecule"
X Link 2024-08-07T19:00Z [----] followers, [--] engagements
"Mechanism 1: Regulating Glucose Spikes Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine"
X Link 2024-08-07T19:00Z [----] followers, [--] engagements
"By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose"
X Link 2024-08-07T19:00Z [----] followers, [--] engagements
"Why is this important As we age our bodies become less able to regulate glucose and insulin levels. High levels of glucose in the body can increase the risk of cardiovascular and metabolic problems and can also damage the endothelial cells that line our blood vessels"
X Link 2024-08-07T19:00Z [----] followers, [--] engagements
"Elevated glucose levels increase the production of mitochondrial reactive oxygen species (ROS). These molecules which contain oxygen and can be either free radicals or non-radicals are highly reactive and can cause damage to cells and tissues"
X Link 2024-08-07T19:00Z [----] followers, [--] engagements
"24).3. The rapamycin group had an obvious increase in the mineral absorption rate and a decrease in osteoclast number. [--]. Levels of osteocalcin a protein produced by osteoblasts were higherindicating more bone formation happening. and"
X Link 2024-08-11T00:02Z [----] followers, [--] engagements
"25) [--]. The levels of TRACB an enzyme produced by osteoclasts were down. Less bone loss. CONCLUSION: Rapamycin increases bone formation and autophagy in osteocytes and osteoblasts"
X Link 2024-08-11T00:02Z [----] followers, [--] engagements
"New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/"
X Link 2024-08-14T00:00Z [----] followers, [---] engagements
"People with chronic inflammatory conditions have continuously overactive immune systems. Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation. How We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation. LG 🧵👇"
X Link 2024-08-14T19:00Z [----] followers, [---] engagements
"Chronic inflammation lies at the core of numerous debilitating diseases from autoimmune disorders to neurodegenerative conditions. While acute inflammation serves a protective purpose chronic inflammation leads to tissue dysfunction and the acceleration of aging"
X Link 2024-08-14T19:00Z [----] followers, [--] engagements
"2) Mechanism 1: Rapamycin Reduced P16 Derived Inflammation The researchers focused on a protein called p16INK4A (p16) which is involved in regulating the cell cycle and senescence. P16 is expressed at high levels in the skin and has been linked to skin aging"
X Link 2024-08-20T19:00Z [----] followers, [--] engagements
"3) In addition to its role in senescence p16 is involved in regulating inflammation in the skin. Inflammation is a key factor in skin aging and high levels of inflammation in the skin have been associated with the development of wrinkles and other signs of aging"
X Link 2024-08-20T19:00Z [----] followers, [--] engagements
"5) Mechanism 2: Topical Rapamycin Reduces Solar Elastosis Researchers also assessed the levels of a skin condition known as solar elastosis. This condition is commonly seen in individuals who have experienced chronic sun exposure particularly in the face neck and hands"
X Link 2024-08-20T19:00Z [----] followers, [--] engagements
"6) Solar elastosis occurs when abnormal elastic fibers accumulate in the skin resulting in a thickened and yellowed appearance. It is a key feature of actinic keratoses which are pre-cancerous skin lesions caused by sun damage"
X Link 2024-08-20T19:00Z [----] followers, [--] engagements
"7) When analyzing the histological images the researchers found that the placebo group had significantly higher levels of disorganized collagen fibers which are associated with sun damage as well as evidence of solar elastosis"
X Link 2024-08-20T19:00Z [----] followers, [--] engagements
"8) Mechanism 4: Cytokeratin 5/6 Distribution in the Basal Layer Improves with Rapamycin Treatment The skin biopsies also revealed that rapamycin had a positive effect on the distribution of cytokeratin 5/6 in the basal layer"
X Link 2024-08-20T19:01Z [----] followers, [--] engagements
"9) Cytokeratin [--] and cytokeratin [--] are crucial components for the development and maintenance of healthy skin. The proper distribution of cytokeratin [--] in the basal layer is vital as it provides structural support to the cells ensuring their shape and function are maintained"
X Link 2024-08-20T19:01Z [----] followers, [--] engagements
"10) Moreover cytokeratin [--] is thought to regulate the process of mitosis which is crucial in the replacement of the skin cells that are shed from the surface of the skin"
X Link 2024-08-20T19:01Z [----] followers, [--] engagements
"11) Researchers found that in the skin samples from people who had used the rapamycin cream the staining for cytokeratin 5/6 was more focused in the basal layer of the skin. Skin samples from the placebo cream showed staining for cytokeratin 5/6 in a different layer of the skin"
X Link 2024-08-20T19:01Z [----] followers, [--] engagements
"The National Institute on Aging Interventions Testing Program (ITP) was designed to be the most exhaustive testing framework and system to evaluate whether longevity molecules extend longevity in mice and understand the underlying mechanisms leading to those benefits. The ITP involves the collaboration of three research labs running experiments in parallel. These labs conducted evaluations on a selection of promising longevity molecules including rapamycin metformin nicotinamide riboside and the SGLT-2 inhibitor canagliflozin among others. At the end of the study only five of the molecules"
X Link 2024-08-23T00:00Z [----] followers, [---] engagements
"1. Regulating Glucose SpikesReducing ROS Acarbose works by blocking an enzyme called alpha-glucosidase which helps digest and absorb carbohydrates in the small intestine. By inhibiting this enzyme acarbose slows down the digestion and absorption of carbs which can help regulate blood sugar levels and prevent spikes in blood glucose. In studies of diabetes patients taking acarbose we have observed an absolute decrease of 0.7% in HbA1c levels which translates to approximately a 10% reduction in typical HbA1c values for diabetes patients. This reduction in blood glucose levels has a profound"
X Link 2024-08-23T00:00Z [----] followers, [--] engagements
"In @michaelamrds low-protein vs high-protein investigation they had an additional two groups which consumed the same low/high protein diets but with the addition of resistance-type exercise"
X Link 2024-08-25T19:00Z [----] followers, [--] engagements
"Notably the high-protein diet when combined with exercise training resulted in greater gains in lean mass with no impairments to glycaemic control or the accumulation of fat mass observed in the non-exercise high-protein group"
X Link 2024-08-25T19:01Z [----] followers, [--] engagements
"Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z"
X Link 2024-08-26T00:00Z [----] followers, [---] engagements
"Healthspan's Dr. Elana Miller highlights the mechanisms through which acarbose promotes healthspan emphasizing its role in metabolic regulation. She also explores the synergistic benefits of combining acarbose with rapamycin noting how their complementary actions enhance longevity and overall health outcomes. https://www.youtube.com/watchv=VyK_Gly4IS0 https://www.youtube.com/watchv=VyK_Gly4IS0"
X Link 2024-09-04T10:00Z [----] followers, [---] engagements
"As we age our bodies experience anabolic resistancea diminished ability to build muscle even with regular exercise and protein intake. A closer look at the serum factors in young blood versus older samples reveals a compelling story. In this weeks research review we explore the mechanisms behind this shift highlighting one key player: the hormone oxytocin. While commonly known for its role in social bonding emerging research shows that oxytocin also plays a significant role in muscle maintenance and fat metabolism. Its natural decline with age may contribute to sarcopenic obesity. We will"
X Link 2024-09-11T15:03Z [----] followers, [---] engagements
"New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/ https://gethealthspan.com/blog/articles/effects-of-high-protein-diets-on-longevity/7r4te9qpag4yimrppmyhvw/"
X Link 2024-09-12T13:02Z [----] followers, [---] engagements
"Introducing the Heart Vitality Panel: an advanced lipid test that enhances cardiovascular risk assessment by incorporating critical biomarkersapolipoprotein B (apoB) and Lipoprotein (a). This panel also offers in-depth LDL and HDL particle analysis. https://gethealthspan.com/labs/advanced-lipid-panel https://gethealthspan.com/labs/advanced-lipid-panel"
X Link 2024-10-01T19:00Z [----] followers, [---] engagements
"Rapamycin seems to increase collagen VII in the basement layer of the skin The mechanism by which rapamycin increases collagen VII is thought that rapamycin's effects on increasing autophagy and proper vesicle trafficking. Learn more: https://gethealthspan.com/blog/articles/inhibiting-skin-senescence-with-topical-rapamycin-sirolimus-for-anti-aging-skincare/40o2ogqdwaekuxak96h3iy/ https://gethealthspan.com/blog/articles/inhibiting-skin-senescence-with-topical-rapamycin-sirolimus-for-anti-aging-skincare/40o2ogqdwaekuxak96h3iy/"
X Link 2024-10-25T00:00Z [----] followers, [---] engagements
"Is menopause delay possible Researchers at Columbia University are studying rapamycins role in conserving womens eggs and slowing reproductive aging. mTOR plays a key role in regulating egg release and by inhibiting mTOR rapamycin may help delay menopause and extend reproductive health. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z"
X Link 2024-10-30T00:00Z [----] followers, [---] engagements
"New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity"
X Link 2024-11-05T20:00Z [----] followers, [---] engagements
"Can a high-protein diet backfire without exercise Recent evidence from the world-leading @LammingLab at the University of Wisconsin-Madison shows that a high-protein diet without any exercise can cause insulin resistance and an accumulation of white adipose tissue in as little as [--] weeks even when matched for caloric intake. @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. Learn more: https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity"
X Link 2024-11-08T09:00Z [----] followers, [---] engagements
"We're excited to share a new chapter in our journey to combat agingthis time for our four-legged family members. Today we're proud to announce the launch of Petspan the first telemedicine clinic dedicated to extending the healthy lifespan of our pets using the same rigorous science that has guided our work with Healthspan. As many of you know our mission at Healthspan has always been to leverage the latest advancements in longevity science to help our patients regain control over the aging process and combat age-related chronic diseases. With Petspan were bringing that same commitment to"
X Link 2024-11-23T10:00Z [----] followers, [---] engagements
"🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR"
X Link 2024-12-08T22:47Z [----] followers, [---] engagements
"🚨 🚨 New Research Review: SGLT2 Inhibitors: The Unexpected Longevity Molecules and Their Mechanistic Impact on Aging Science by @RNMarshallPhD https://hspan.io/ksmRdk https://hspan.io/ksmRdk"
X Link 2025-01-05T15:51Z [----] followers, [---] engagements
"The Longevity Blueprint Connecting mTOR and Mitochondria: The Novel Synergy Between Rapamycin and Urolithin A - https://mailchi.mp/gethealthspan/glymphatic-system-12724604 https://mailchi.mp/gethealthspan/glymphatic-system-12724604"
X Link 2025-01-12T16:34Z [----] followers, [---] engagements
"Researchers at Columbia University are exploring the potential of rapamycin to conserve women's eggs and delay menopause by inhibiting mTOR. mTOR plays a key role in regulating egg release. By inhibiting mTOR rapamycin may slow down reproductive aging. https://tinyurl.com/ydauaj8z https://tinyurl.com/ydauaj8z"
X Link 2025-01-23T20:00Z [----] followers, [---] engagements
"We're excited to share a new chapter in our journey to combat agingthis time for our four-legged family members. Today we're proud to announce the launch of Petspan the first telemedicine clinic dedicated to extending the healthy lifespan of our pets using the same rigorous science that has guided our work with Healthspan. As many of you know our mission at Healthspan has always been to leverage the latest advancements in longevity science to help our patients regain control over the aging process and combat age-related chronic diseases. With Petspan were bringing that same commitment to"
X Link 2025-01-26T01:00Z [----] followers, [---] engagements
"🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR"
X Link 2025-02-06T14:00Z [----] followers, [---] engagements
"🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR"
X Link 2025-02-23T20:00Z [----] followers, [---] engagements
"🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: https://hspan.io/l9d6jR https://hspan.io/l9d6jR"
X Link 2025-03-27T19:00Z [----] followers, [---] engagements
"@mamie_tenney @NickLuto @bryan_johnson Petspan focuses on rapamycin protocols for pets. You can learn more about it here: https://www.petspan.com/ https://www.petspan.com/"
X Link 2025-04-03T14:48Z [----] followers, [--] engagements
"For over a century scientists believed that amyloid plaques in the brain were the root cause of Alzheimers disease. But new researchincluding work from Dr. Francisco Gonzalez-Limasuggests that problems with blood flow and mitochondrial energy production may actually occur before plaque buildup and could be what initiates the disease in the first place. Last Sunday Healthspans lead scientist Dr. Rich LaFountain explored this emerging framework by reviewing decades of research from the Gonzalez-Lima Labalongside insights from vascular neuroscientist Dr. Jack de la Torre. Their findings point to"
X Link 2025-04-11T07:00Z [----] followers, [---] engagements
"New research from @LammingLab indicates that high protein diets without exercise cause insulin resistance and fat accumulation What does that mean @RNMarshallPhD explores the impact of high-protein diets on longevity and metabolic health. https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity https://gethealthspan.com/science/article/effects-of-high-protein-diets-on-longevity"
X Link 2025-04-27T00:00Z [----] followers, [---] engagements
"🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: [--] https://hspan.io/l9d6jR https://hspan.io/l9d6jR"
X Link 2025-04-28T00:00Z [----] followers, [---] engagements
"As researchers evaluating mitochondrial function begins with two key parameters: the ability of a compound to boost ATP production and its capacity to reduce oxidative stress. These metrics are fundamental to assessing mitochondrial efficiencyessential for sustaining cellular energy and minimizing the oxidative damage that accelerates aging. Compounds that achieve these outcomes hold potential as geroprotective interventions particularly in aging tissues where mitochondrial decline is most evident. This week we apply this framework to Urolithin A a gut-derived metabolite recognized for its"
X Link 2025-05-01T19:00Z [----] followers, [---] engagements
"🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2"
X Link 2025-06-11T18:00Z [----] followers, [---] engagements
"🧬 A mitochondrial enzymeusually locked deep inside our cellshas now been found circulating in the blood of long COVID patients. And it may hold the key to understanding fatigue brain fog and post-viral exhaustion. The enzyme is called PRDX3 and its doing more than signaling damageit may be pointing us to the heart of long COVID: mitochondrial failure. 👇 Heres what the latest research revealsand how it might reshape recovery strategies: 🔍 The Mystery of Long COVID Millions still suffer from lingering symptoms after COVIDdebilitating fatigue cognitive slowing dizziness and shortness of"
X Link 2025-06-13T00:36Z [----] followers, [---] engagements
"🧠 What if Alzheimers isnt caused by plaques at allbut by an energy crisis inside your brain cells When you dig into the research of Dr. Francisco Gonzalez-Lima and Dr. Jack de la Torre on mitochondrial dysfunction in Alzheimers diseaseand the potential of methylene blue to restore neuronal energyyou begin to see a radically different framing of the disease. If you accept the premise that one of the primary drivers of AD is an energy shortfall within neurons the question becomes: where is that deficit happening The answer Gonzalez-Lima argues is almost certainly the mitochondria. His work"
X Link 2025-06-22T19:00Z [----] followers, [---] engagements
"🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2"
X Link 2025-06-28T09:00Z [----] followers, [---] engagements
"🧬 Is aging just wear-and-tear or is it a built-in flaw in our biological software Dr. Joo Pedro de Magalhes @jpsenescence proposes an interesting perspective on the theoretical underpinning of aging: our DNA is the hardware while the epigenomethe chemical tags that turn genes on or offacts as software. Over time this software may become maladaptive driving the aging process rather than merely reacting to damage. Heres what you need to know. 👇 🔍 The Research In a his paper Ageing as a software design flaw Dr. de Magalhes compares the epigenome to computer software that executes genetic"
X Link 2025-07-05T00:00Z [----] followers, [---] engagements
"What Does It Really Mean to Be Metabolically Flexible In this week's episode of Beyond Healthspan we break down one of the most influential papers in exercise physiology: Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate Fat and Carbohydrate Oxidation Responses to Exercise by @doctorinigo and Dr. George Brooks. We explore: 🔬 What metabolic flexibility actually isand how to measure it 🧬 Why lactate isnt just a waste product but a key fuel and signal ⚡ How professional athletes use fat and carbs differentlyand what we can learn from it 🧠 How mitochondrial health"
X Link 2025-07-05T19:00Z [----] followers, [---] engagements
"🧬 A diabetes drug that makes you pee out sugar is now making headlines as a potential anti-aging therapy. Today the Wall Street Journal published: These Diabetes Drugs Are Finding New Life as an Antiaging Hack spotlighting SGLT2 inhibitors as a surprising tool in longevity science. Unlike metformin or acarbose these drugs dont just alter insulinthey block glucose reabsorption in the kidneys causing 7090g of sugar to be excreted daily. Heres why geroscientists are paying attention. 👇 🔍 Background: From Blood Sugar to Lifespan Extension SGLT2 inhibitors (Sodium-Glucose Cotransporter-2"
X Link 2025-07-09T19:00Z [----] followers, [---] engagements
"💊 Enter Rapamycin: Resetting the Fullness Signal If mTOR overactivation is jamming the brains ability to hear leptin could inhibiting mTOR restore the signal Thats exactly what researchers tested in a recent series of experiments using rapamycin a well-known mTOR inhibitor. Rapamycin has long been studied for its ability to extend lifespan but here it was used to address something very different: reversing leptin resistance in the hypothalamus"
X Link 2025-07-10T19:00Z [----] followers, [--] engagements
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