#  @d_stock07734 d_stock d_stock posts on X about $nwbo, acquisition, $mrk, has been the most. They currently have [---] followers and [----] posts still getting attention that total [---] engagements in the last [--] hours. ### Engagements: [---] [#](/creator/twitter::1660707117722902539/interactions)  - [--] Week [------] -45% - [--] Month [-------] +43% - [--] Months [-------] +59% - [--] Year [-------] +125% ### Mentions: [--] [#](/creator/twitter::1660707117722902539/posts_active)  - [--] Month [--] -67% - [--] Months [---] +62% - [--] Year [---] +186% ### Followers: [---] [#](/creator/twitter::1660707117722902539/followers)  - [--] Week [---] +0.31% - [--] Month [---] +3.80% - [--] Months [---] +4.70% - [--] Year [---] +28% ### CreatorRank: [---------] [#](/creator/twitter::1660707117722902539/influencer_rank)  ### Social Influence **Social category influence** [stocks](/list/stocks) [finance](/list/finance) [currencies](/list/currencies) [technology brands](/list/technology-brands) [countries](/list/countries) [cryptocurrencies](/list/cryptocurrencies) [travel destinations](/list/travel-destinations) [exchanges](/list/exchanges) [celebrities](/list/celebrities) [automotive brands](/list/automotive-brands) **Social topic influence** [$nwbo](/topic/$nwbo) #9, [acquisition](/topic/acquisition), [$mrk](/topic/$mrk) #20, [has been](/topic/has-been), [$8750t](/topic/$8750t), [dc](/topic/dc) #1862, [investment](/topic/investment), [in the](/topic/in-the), [combo](/topic/combo), [solid](/topic/solid) **Top accounts mentioned or mentioned by** [@andrewcaravello](/creator/undefined) [@metacollectiveg](/creator/undefined) [@mdendream](/creator/undefined) [@dcvaxdaw](/creator/undefined) [@maveric92283613](/creator/undefined) [@flemmingbruce](/creator/undefined) [@hoffmann6383](/creator/undefined) [@alphavestcap](/creator/undefined) [@patrickwalsh14](/creator/undefined) [@gonegoodguy](/creator/undefined) [@peterbrit](/creator/undefined) [@exosome](/creator/undefined) [@investor2013us](/creator/undefined) [@bunastarebio](/creator/undefined) [@pratapsinghmd](/creator/undefined) [@apwriter](/creator/undefined) [@bio99bio99](/creator/undefined) [@smith348572](/creator/undefined) [@michael48826289](/creator/undefined) [@immortabio](/creator/undefined) **Top assets mentioned** [Merck & Co., Inc. (MRK)](/topic/$mrk) [AbbVie Inc (ABBV)](/topic/$abbv) [Insmed, Inc. (INSM)](/topic/$insm) [Bristol-Myers Squibb Co (BMY)](/topic/$bmy) [Amgen, Inc. (AMGN)](/topic/$amgn) [Gilead Sciences, Inc. (GILD)](/topic/$gild) [ImmunityBio, Inc. Common Stock (IBRX)](/topic/$ibrx) [AstraZeneca PLC (AZN)](/topic/$azn) [Johnson & Johnson (JNJ)](/topic/$jnj) [Alphabet Inc Class A (GOOGL)](/topic/$googl) [Sanofi (SNY)](/topic/sanofi) [Regeneron Pharmaceuticals Inc (REGN)](/topic/$regn) [Novartis AG (NVS)](/topic/novartis) [Summit Therapeutics Inc. Common Stock (SMMT)](/topic/$smmt) ### Top Social Posts Top posts by engagements in the last [--] hours "@sanderhamburger @ATLnsider @Anonymous275111 @RickHancock17 @metacollectiveG @Mionaer1 @sharpie510 @wpri12 Have you not read the slide from Dr. Bosch's presentation No other company can have such a marvelous achievement like NWBO. These molecules binding with peptides will activate CD4 t cells which play critical role in immune memory. Pretty soon patients receiving DCVax-L don't" [X Link](https://x.com/d_stock07734/status/1685788594365988864) 2023-07-31T20:34Z [---] followers, [----] engagements "@3_Putt_Bogey_ @ATLnsider Each day the traffic on ihub is over 1.6m. That's why" [X Link](https://x.com/d_stock07734/status/1697287857994367322) 2023-08-31T16:38Z [---] followers, [--] engagements "@andrewpannu Keytruda lacks of efficacy in treating cold tumors which account for about 80% of solid tumors. T- cell infiltration into cold tumor sites is essential for Keytruda to work" [X Link](https://x.com/d_stock07734/status/1701808183419805845) 2023-09-13T04:01Z [---] followers, [----] engagements "@FormerPharmaGuy Try Fidelity. It has no fees" [X Link](https://x.com/d_stock07734/status/1702420582145683888) 2023-09-14T20:34Z [---] followers, [--] engagements "@Cheesehammer11 Will the main media report the results from the manuscript before the review is done and the paper is officially published" [X Link](https://x.com/d_stock07734/status/1702792438354432347) 2023-09-15T21:12Z [---] followers, [---] engagements "@metacollectiveG Just three shots within [--] days no chemo no radiation no terrible side-effects and patients can live over nine years. It is beyond miracle" [X Link](https://x.com/anyuser/status/1702832746857410723) 2023-09-15T23:52Z [---] followers, [----] engagements "@TommyBaxendale AI Musella along with Fabio Iwamoto are on the team of Xcures mentioned in the new moonshot announcement. Take a look the board directors and partners" [X Link](https://x.com/d_stock07734/status/1703521605907845126) 2023-09-17T21:29Z [---] followers, [---] engagements "@MonsonVO @KryptyPop @BiopharmIQ The reason is simple. $NWBO will make obsolete the treatment technology from all the companies in his portfolio" [X Link](https://x.com/d_stock07734/status/1703608978624610677) 2023-09-18T03:16Z [---] followers, [----] engagements "@FormerPharmaGuy Keytruda accounts for about one-half of the Merck's revenue. Do you know what happened to Abbvie after the patent expiration of its Humira" [X Link](https://x.com/d_stock07734/status/1703788241629954111) 2023-09-18T15:09Z [---] followers, [--] engagements "@flaskworks @MonsonVO @KryptyPop @BiopharmIQ I don't think that's the reason that media doesn't report DCVax-L. The reason is NWBO will pose a great threat to many companies in oncology business which put a lot ads on those media" [X Link](https://x.com/d_stock07734/status/1703809990568317248) 2023-09-18T16:35Z [---] followers, [---] engagements "@jman4956 @BIO99_BIO99 Before the JAMA paper was published FDA had new guidance on ECA. Before NWBO submits application for approval FDA issued new guidance on RWD/RWE. It doesn't look like a coincident" [X Link](https://x.com/d_stock07734/status/1703968946792120531) 2023-09-19T03:07Z [---] followers, [---] engagements "@Investor2013Us @jman4956 @BIO99_BIO99 It can also be used for the approval of DCVAX-L with poly-iclc. I strongly believe the UK special problem is using this combo" [X Link](https://x.com/d_stock07734/status/1703987712007561441) 2023-09-19T04:21Z [---] followers, [--] engagements "@hoffmann6383 @TommyBaxendale Great point I never thought about this way. Now I think it is highly possible. If this combination gets approval then massive trials can be carried out in the next stage and approval can be granted using RWD" [X Link](https://x.com/d_stock07734/status/1704106755377054073) 2023-09-19T12:14Z [---] followers, [---] engagements "@TommyBaxendale @hoffmann6383 You are right. I believe the paper came from UPenn and Dr. Liau is a coauthor. As a matter of fact with machine learning and AI stuff they can detect pseudopgression. I read some papers on this subject" [X Link](https://x.com/d_stock07734/status/1704148317872013621) 2023-09-19T14:59Z [---] followers, [--] engagements "@xLUCCIOx Does Netflix have the series Star Trek Star Trek never ends. LoL" [X Link](https://x.com/d_stock07734/status/1705342609806217718) 2023-09-22T22:05Z [---] followers, [--] engagements "@fireman02360 @CCCdet27 @FormerPharmaGuy @ItsMikePoarch It is harder and harder to have disruptive technology and science. NW has no competitors in the foreseeable future" [X Link](https://x.com/d_stock07734/status/1707457574725988833) 2023-09-28T18:09Z [---] followers, [--] engagements "@fireman02360 @FormerPharmaGuy @CCCdet27 @ItsMikePoarch I don't recall saying that decisions are solely based on those two things. Decision are based on tons of reading of relevant journal papers. In reasonable near term $100 is still under value. As a matter of fact selling the majority under $100 is naive" [X Link](https://x.com/d_stock07734/status/1707497580756644128) 2023-09-28T20:48Z [---] followers, [--] engagements "@maveric92283613 @patrickwalsh14 @GoneGoodguy Treatments for brain cancer was specifically mentioned in the NCI [----] budget. Feel like the pilot projects are related to the current combo trial" [X Link](https://x.com/d_stock07734/status/1707570512660975795) 2023-09-29T01:38Z [---] followers, [---] engagements "@noMidwestHedgie @metacollectiveG You obviously haven't read about the currently ongoing combo trial initated two years ago. Had you read it carefully you would have bailed long time ago. You see all the measures You haven't seen anything like this while you have been kicking grandma shins" [X Link](https://x.com/d_stock07734/status/1708188622929678753) 2023-09-30T18:34Z [---] followers, [---] engagements "@JayLourenco @metacollectiveG The man listed many times in his tweets the possible collaborators. Did you try to do your own DD to see if the list makes sense Collaborators: $MRK $REGN $BMY $JNJ $GILD $AMGN $RHHBY $AZN" [X Link](https://x.com/d_stock07734/status/1708918322115317996) 2023-10-02T18:54Z [---] followers, [---] engagements "@MariaG816 @dcvax4life @metacollectiveG @StylianosIkono1 They know checkmate is coming. If they read the Nature preprint they probably knew why LP went to loan shark to get the loan: To lock them deep in the trap" [X Link](https://x.com/d_stock07734/status/1709029271128150144) 2023-10-03T02:15Z [---] followers, [---] engagements "@maveric92283613 On the other side Merck has been preparing the platform for new types of RWD based clinical trials" [X Link](https://x.com/d_stock07734/status/1709325655249436862) 2023-10-03T21:52Z [---] followers, [--] engagements "@Investor2013Us @bunastarebio @pratapsinghmd You don't think the partnership has been forged quite a while ago" [X Link](https://x.com/d_stock07734/status/1710108928678269095) 2023-10-06T01:45Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd I always doubt about buyout. Correct me if I am wrong. For buyout to be feasible should buyer and seller have a rough idea about the potential value that DCVax-L can bring Take Prometheus as example two rare diseases Merck had pretty good idea about its current market cap" [X Link](https://x.com/d_stock07734/status/1710300061660262639) 2023-10-06T14:24Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd In the past [--] years the total number of unique peptides found is [----] through APOLLO Network. DCVax alone can tremendously expand the current database which will bring unfathomable value. You tell me how buyout is possible" [X Link](https://x.com/d_stock07734/status/1710303795891122306) 2023-10-06T14:39Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd IMO $NWBO will have partnership with both the public sectors and the private sectors. $MRK is just one of them. The solid tumor market is big enough for every big BP to have a slice of pie" [X Link](https://x.com/d_stock07734/status/1710304247911166241) 2023-10-06T14:41Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd IMO disruptive technology faces much less competition. With the IP NWBO owns other BPs can combine NWBO's base formula with their own products and compete against each other so that patients get the maximum benefit. Merge/Buyout is not a good option" [X Link](https://x.com/d_stock07734/status/1710333037697777742) 2023-10-06T16:35Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd BTW BPs have been awaken. Five hundred clinical trials on dendritic cells were registered on Have we seen any breakthrough other than DCVax-L" [X Link](https://x.com/d_stock07734/status/1710333634140389407) 2023-10-06T16:38Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd That's not a good illustration. Dendritic cell was found in 1970s. Dr. Steimann elicited anti-tumor response from dendritic cell in 1990s. After thirty years finally we have a dendritic cell vaccine" [X Link](https://x.com/d_stock07734/status/1710354350592102813) 2023-10-06T18:00Z [---] followers, [---] engagements "@Investor2013Us @bunastarebio @pratapsinghmd Check out maverick_1's tweets in which he repeatedly mentioned several BPs as potential collaborators. Again no buyout or merge. I think we have spent enough time on this topic" [X Link](https://x.com/d_stock07734/status/1710354677554987234) 2023-10-06T18:01Z [---] followers, [--] engagements "@Investor2013Us @JdBell20 @bunastarebio @pratapsinghmd Again no merge no buyout. No BP cannot afford it. If you seriously check if BPs are building cell manufacturing facility in the past two years and have job openings related to proteomic analysis you will know there is no buy out and no merger" [X Link](https://x.com/d_stock07734/status/1710804258973532281) 2023-10-07T23:48Z [---] followers, [--] engagements "@exosome @Thislifetime22 @malukDcabob @bioboybull @AminoProtein Here are some slides from Dr. Bosch's present. He mentioned from a single sample over thirty seven thousand peptides were found. My question: will NWBO be able to file patents for all the new peptides found by DCVax-L from all solid tumors" [X Link](https://x.com/d_stock07734/status/1711159826850381965) 2023-10-08T23:21Z [---] followers, [----] engagements "@FormerPharmaGuy @fornybarbio Why are you frustrated You just have a tiny position. If it takes one extra month to get everything correct it is totally worth it. In one month you may realize who is really amateurish" [X Link](https://x.com/d_stock07734/status/1713030048066703475) 2023-10-14T03:12Z [---] followers, [---] engagements "@maveric92283613 then those collaborators need to hire high-caliber professionals to do proteomic analysis. ELISA is the one mentioned a lot in Dr. Liau's papers which is related to proteomic analysis" [X Link](https://x.com/d_stock07734/status/1713599550483505276) 2023-10-15T16:55Z [--] followers, [--] engagements "@maveric92283613 Take a look at $JNJ first. Here is one job opening: Senior Scientist Proteomics Even though $JNJ has one approval of car-t therapy the job description still makes me wonder if it has anything to do with possible collaboration with NWBO" [X Link](https://x.com/d_stock07734/status/1713603676122579153) 2023-10-15T17:12Z [---] followers, [---] engagements "@maveric92283613 The interesting thing is that similar job openings for other BPs. Take Roche for instance" [X Link](https://x.com/d_stock07734/status/1713604354240889294) 2023-10-15T17:14Z [---] followers, [--] engagements "@metacollectiveG NWBO already made some info. explicit. The company said it has 1.7m pages of documentation foe filing and it will require MAA 150-day assement timeline. How's it possible to finish the review for a totally brand new therpay within [---] days Reviewing totally new therapy should" [X Link](https://x.com/d_stock07734/status/1713708325303423127) 2023-10-16T00:07Z [---] followers, [---] engagements "@metacollectiveG take much longer time since the reviewers are not familiar. It is obvious the only possibility is rolling review. Sorry for the weak hands on Friday who cannot read the context between the lines" [X Link](https://x.com/d_stock07734/status/1713709219067658746) 2023-10-16T00:11Z [---] followers, [---] engagements "@BIO99_BIO99 What could bring this level of confidence to the government White House deputy chief of staff Bruce Reed said in a statement. "At his direction the entire federal government is mobilizing like never before to end cancer as we know it."" [X Link](https://x.com/d_stock07734/status/1714317588107337809) 2023-10-17T16:28Z [---] followers, [----] engagements "@Lewis_Tierney @albtur_mnymkrs The project was just renewed. But don't forget about $BMY which had a five-year collaboration with Robert Prins and Linda Liau" [X Link](https://x.com/d_stock07734/status/1715013207708897533) 2023-10-19T14:33Z [---] followers, [---] engagements "@sanderhamburger @ABenS2060 @ATLnsider At this stage plx-3397 cannot be explicitly mentioned. As a matter of fact this is the part that all the concerning parties are trying to hide. You simply cannot get it" [X Link](https://x.com/d_stock07734/status/1715790285999845635) 2023-10-21T18:00Z [--] followers, [--] engagements "@WayneLee1983 @metacollectiveG @JackNdreu I don't think it matters when it will be published. What it matters is that the preprint sends a clear message on the prospective trials in which biomarker analysis plays a key role in evaluating the outcome of the trials. Note that the current combo trial was mentioned" [X Link](https://x.com/d_stock07734/status/1718690408505409909) 2023-10-29T18:04Z [---] followers, [--] engagements "@KeoghBernard @peter_brit I doubt about buyout. I give you just one reason. In Dr. Bosch's presentation we can see from one example that tens of thousands of peptides can be extracted. I was always wondering if NWBO could file patents for all the newly found tumor specific peptides from solid tumors" [X Link](https://x.com/d_stock07734/status/1720454910808875490) 2023-11-03T14:56Z [---] followers, [---] engagements "@exosome Likewise for CSF1R-I (PLX3397). Merck and Daichii had a collaboration trial using PLX3397 combined with Keytruda. The trial was terminated because of lack of efficacy. But once it is combined with DCVax-L we can see amazing efficacy in animal models" [X Link](https://x.com/d_stock07734/status/1721241388262572122) 2023-11-05T19:01Z [---] followers, [---] engagements "@exosome If you take a look at the clinical trial of DCVax-L with poly-iclc the objective was to find the most effective combination ingredient for DCVax-L and the number of enrollment was [--] patients. But with [--] patients [--] on poly-iclc [--] on resiquimod [--] on" [X Link](https://x.com/d_stock07734/status/1721242365258592655) 2023-11-05T19:05Z [---] followers, [---] engagements "@HenryMuney @biggercapital @joanlappin @ATLnsider @rago_carlo @wkovash @GeneralVentures Humira brought Abbvie $2000 over [--] years. But the 1st month biosimilar hits the market revenue from Humira down by 26%. Both Keytruda and Opdivo will expire in [--] yrs and there is no difference in efficacy. They need DCVax-L" [X Link](https://x.com/d_stock07734/status/1724082365369126987) 2023-11-13T15:10Z [---] followers, [---] engagements "@TheeBeardedG @maveric92283613 @RichFairgrieve @rsloftx @elonmusk What does it mean "Phase II trials planned" Do we have PR on this" [X Link](https://x.com/d_stock07734/status/1726715943903248461) 2023-11-20T21:35Z [---] followers, [---] engagements "@sharpie510 I just love these figures and have to post them again. For CIs to work you have to have plenty t cells in tumor micro-environment. But 80% of solid tumors have t cell depleted micro-enironment. That's why CIs lack of efficacy for cold tumors. For p3 trial patients after SOC" [X Link](https://x.com/d_stock07734/status/1726778604476858761) 2023-11-21T01:44Z [---] followers, [---] engagements "@dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @MDendream @rickcav @apwriter @Lewis_Tierney If you google it you will see many researcher were trying to use the same protocl on other targets and failed. Dr. Reardon who just wrote the hitting piece failed in trying to combine peptide vaccine with poly-iclc and imiquimod (similar to resiquimod)" [X Link](https://x.com/d_stock07734/status/1728637316636254316) 2023-11-26T04:50Z [---] followers, [---] engagements "@dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @MDendream @rickcav @apwriter @Lewis_Tierney Carolyn Britten currently Vice President Early Development Oncology at Amgen who used to work at Jonsson Comprehensive Cancer Center at UCLA tried DC vaccines with the same combination on pancreatic cancer at Medical University of South Carolina and failed" [X Link](https://x.com/d_stock07734/status/1728638771459940431) 2023-11-26T04:56Z [---] followers, [---] engagements "@MDendream @dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @rickcav @apwriter @Lewis_Tierney Well since I am new I don't care about GTM strategy/execution or impact on market value. I only care how revolutionary and disruptive the technology is. As a matter of fact in the case of NWBO too much experience could prevent someone from being bold and aggressive" [X Link](https://x.com/d_stock07734/status/1728646234041143651) 2023-11-26T05:25Z [---] followers, [---] engagements "@metacollectiveG @MDendream @dcvaxdaw @patrickwalsh14 @woodman267 @rickcav @apwriter @Lewis_Tierney I agree. For those who complain about crawling speed I wonder if they know how big is the empire LP and LG are trying to build. My gut tells me the size of the empire will be well beyond my imagination" [X Link](https://x.com/d_stock07734/status/1728650992466506181) 2023-11-26T05:44Z [---] followers, [---] engagements "@MDendream @metacollectiveG @dcvaxdaw @patrickwalsh14 @woodman267 @rickcav @apwriter @Lewis_Tierney What did those people in Detroit say when Elon Musk decided to manufacture EV What did the people in Boeing think about Elon Musk when he tried to design recycle rockets I know it is different field. But comparison can be made" [X Link](https://x.com/d_stock07734/status/1728792516311257194) 2023-11-26T15:07Z [---] followers, [--] engagements "@BIO99_BIO99 Not a good news for Regeneron which has big bet on chimeric antigen receptor (CAR) T-cell therapy. But it surely makes us love DCVax-L even more. Has DCVax-L bring to immune system anything artificially made Did NWBO use synthetic this or that or engineering this or that None" [X Link](https://x.com/anyuser/status/1729585905550127203) 2023-11-28T19:39Z [---] followers, [----] engagements "@augie_percoco @peter_brit No doubt there was an ulterior motive. Just scroll down the webpage and you will see why they wrote the hitting piece" [X Link](https://x.com/d_stock07734/status/1730106336816361831) 2023-11-30T06:07Z [---] followers, [---] engagements "@augie_percoco @peter_brit Dr. Reardon currently is the PI of the clinical trial sponsored by Immunomic Therapeutics. He is also on the Advisory Board of the company. Did you see he disclosed this information in the paper" [X Link](https://x.com/d_stock07734/status/1730108473269014652) 2023-11-30T06:16Z [---] followers, [----] engagements "@BIO99_BIO99 @InvestorZlu Zlu Recall when bio99 wrote the Reddit post you were concerned about that the SOC in p3 trial could be detrimental to patients in a way it could suppress immune response. I was trying to see if there are any other clinical trials that used Expansion of T cell" [X Link](https://x.com/d_stock07734/status/1733562018538365386) 2023-12-09T18:59Z [---] followers, [--] engagements "@InvestorZlu @BIO99_BIO99 Seems to me NWBO does not want to get big attention for now" [X Link](https://x.com/d_stock07734/status/1733861701378887847) 2023-12-10T14:50Z [---] followers, [---] engagements "@apwriter Oh yeah The hiring frenzy has been going on for a while. Use the keywords to Google it merck + west point + jobs Sign up for the job alerts and monitor the job postings. You will be amazed" [X Link](https://x.com/d_stock07734/status/1733873050448216397) 2023-12-10T15:35Z [---] followers, [---] engagements "@exosome Dr. Ichim did you by any chance read the interview of Dr. Monica Bertagnolli by NPR It seems like she was very excited about using immunotherapy to treat cancer" [X Link](https://x.com/d_stock07734/status/1735168228043747635) 2023-12-14T05:21Z [---] followers, [---] engagements "@dcvaxdaw @metacollectiveG @StockSlanginSam @LisainNJUSA @FlemmingBruce @GREEK__G0D @escctrl74 @alphavestcap I thought they were fools. It turns out they are hyenas. How is it possible to reason things out with hyenas" [X Link](https://x.com/d_stock07734/status/1736646309849805237) 2023-12-18T07:15Z [---] followers, [---] engagements "@metacollectiveG Humira for an array of inflammatory diseases brought AbbVie $200b in [--] years. Cannot imagine how much DCVax-L which can treat and potentially cure all solid tumors will bring to NWBO. Must be a big multiplier of $200b" [X Link](https://x.com/d_stock07734/status/1737920312908345511) 2023-12-21T19:37Z [---] followers, [---] engagements "@dcvaxdaw @jamestheright1 @Siddco1 How about revolutionary science in biotech" [X Link](https://x.com/d_stock07734/status/1738248834571030582) 2023-12-22T17:23Z [---] followers, [--] engagements "@jamestheright1 @dcvaxdaw @Siddco1 So you do agree there are liars among them" [X Link](https://x.com/d_stock07734/status/1738581843216122150) 2023-12-23T15:26Z [---] followers, [--] engagements "@hoffmann6383 Here is the transcript" [X Link](https://x.com/d_stock07734/status/1744844174015226310) 2024-01-09T22:10Z [---] followers, [---] engagements "@hoffmann6383 While some Merck & Co. investors may still get the heebie-jeebies when thinking about Keytrudas patent cliff in [----] but the companys CEO Rob Davis now thinks its just another year. Just another year Sounds so confident. He must have known" [X Link](https://x.com/d_stock07734/status/1745503581116227739) 2024-01-11T17:50Z [---] followers, [---] engagements "@hoffmann6383 what happened to Abbvie when its blockbuster drug Humira hit the patent cliff. Does Merck currently have something under development that will help Merck surpass the patent cliff I think we will know the answer soon" [X Link](https://x.com/d_stock07734/status/1745504633135518084) 2024-01-11T17:55Z [---] followers, [--] engagements "@dcvaxdaw @ImmortaBio @andrewcaravello DM I cannot see BO. BO is not good for the benefit of patients. I read Dr. Liau's paper in which she talked about overexpression of pd-L1 from cancer cells. You see those BPs which have PD-L1 inhibitors can combine their products with DCVax-L. Let BPs compete with each other" [X Link](https://x.com/d_stock07734/status/1745512685876191381) 2024-01-11T18:27Z [---] followers, [---] engagements "@dcvaxdaw @ImmortaBio @andrewcaravello I suspect there must be a good reason that it took a long time to publish the JAMA paper. Here the top [--] pharma companies by [----] revenue. If you check how many clinical trials on DCs they have sponsored I am sure you would be amazed" [X Link](https://x.com/d_stock07734/status/1745640729706152264) 2024-01-12T02:55Z [---] followers, [---] engagements "@dcvaxdaw @ImmortaBio @andrewcaravello Amgen: [--] Roche: [--] BMY: [--] Pfizer: [--] Sanofi: [--] Merck: [--] AbbVie: [--] GSK: [--] J&J: [--] Novartis: [--] (Asthma) AstraZeneca: [--] Takeda: [--] Eli Lilly: [--] Gilead: [--] Bayer: [--] (Multiple Sclerosis) Boehringer Ingelheim: [--] Novo Nordisk: [--] Moderna: [--] Merck KGaA: [--] BioNTech: 0" [X Link](https://x.com/anyuser/status/1745644819634962907) 2024-01-12T03:12Z [--] followers, [--] engagements "@maveric92283613 @dcvaxdaw @ImmortaBio @andrewcaravello We can see clearly that those BPs don't have the infrastructure for the type of cell therapy that NWBO developed. If BPs want to partner with NWBO they have to hire new people and build new facilities" [X Link](https://x.com/d_stock07734/status/1745849542589763731) 2024-01-12T16:45Z [---] followers, [---] engagements "@maveric92283613 @dcvaxdaw @ImmortaBio @andrewcaravello A job from Merck "The group is responsible for establishing the science engineering and knowledge required for today's innovative and accelerated commercialization of novel Vaccines Biologics and pharmaceutical products and combination products."" [X Link](https://x.com/d_stock07734/status/1746036676609073367) 2024-01-13T05:09Z [---] followers, [---] engagements "@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello Thanks Mav. Here is the invaluable list. Collaborators:$MRK $AMGN$REGN$BMY$JNJ $GILD$RHHBY$AZN Take $GILD as an example. For a company willing to pay up to $658.5m to have a license from a company which only has preclinical data on dendritic cells to treat RA" [X Link](https://x.com/d_stock07734/status/1746316528172118186) 2024-01-13T23:41Z [---] followers, [---] engagements "@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello it is certain that $GILD would love to pay many times of $600m to get license from NWBO to treat many tough virus. We can see in the combo trial patients with HIV hepatitis B & C TB positive are excluded in the trial. What if in the compassionate use" [X Link](https://x.com/d_stock07734/status/1746319652135793117) 2024-01-13T23:53Z [---] followers, [---] engagements "@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello patients with these viruses or bacteria can be included and the viruses or bacteria were eliminated Given the fact that $GILD once spent one third of its market cap to buy the cure drug for hepatitis C I have no doubt $GILD would like to spend big money on DCVax-L" [X Link](https://x.com/d_stock07734/status/1746320908220875156) 2024-01-13T23:58Z [---] followers, [---] engagements "@maveric92283613 @sharpie510 This reminds me that most likely it is Merck which forced AI to take down Dr. Liau's webinar video twice. Now I suspect LP can name the rules for house of cards and BPs have to following the rules" [X Link](https://x.com/d_stock07734/status/1746330177968177374) 2024-01-14T00:35Z [---] followers, [---] engagements "@maveric92283613 @sharpie510 Here is the combo trial between BMY and NWBO which was supposed to start in January [----]. But in [----] the PI of the trial had meetings with both BMY and Merck according to Seems to methis two BPs fought for the trial" [X Link](https://x.com/d_stock07734/status/1746332284838371565) 2024-01-14T00:43Z [---] followers, [---] engagements "@metacollectiveG @compozee_ @fireman02360 @dcvaxdaw @LisainNJUSA @mittypost I hope the approval comes from all RAs. Merck's vaccine manufacturing facility is going to operate 24/7 early this year. What if it has something to do with DCVax-L Then DCVax-L must be approved by FDA before Merck can manufacture it. https://careers.utpb.edu/jobs/merck-co-inc-west-point-quality-line-oversight-program-2024/ https://careers.utpb.edu/jobs/merck-co-inc-west-point-quality-line-oversight-program-2024/" [X Link](https://x.com/d_stock07734/status/1747273459603038540) 2024-01-16T15:03Z [---] followers, [---] engagements "@smith348572 @MDendream @metacollectiveG @dcvaxdaw @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 So $NWBO has to file for approval with different RAs separately It doesn't make sense. How did you come up with the number $20" [X Link](https://x.com/d_stock07734/status/1747803773903216745) 2024-01-18T02:11Z [---] followers, [---] engagements "@MDendream @dcvaxdaw @Mtnjack68 @metacollectiveG @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 Think whatever you like. If you have no conviction and lose confidence in the management don't torture yourself. Find a traditional company that fits your mindset" [X Link](https://x.com/anyuser/status/1747981095080194218) 2024-01-18T13:55Z [--] followers, [---] engagements "@MDendream @dcvaxdaw @Mtnjack68 @metacollectiveG @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 Are you conjuring up something You almost strike me as a replica of flipper on ihub" [X Link](https://x.com/d_stock07734/status/1748073113894498537) 2024-01-18T20:01Z [---] followers, [---] engagements "@MDendream @mattkolleck1 @metacollectiveG the amazing t cell increase and expansion resulting from the treatment. But did BPs like an amazing treatment like DCVax-L back then Absolutely no. DCVax-L didn't fit their business model. Note that Merck is the manufacturer of TMZ" [X Link](https://x.com/d_stock07734/status/1748446946417590488) 2024-01-19T20:46Z [---] followers, [---] engagements "@MDendream @mattkolleck1 @metacollectiveG IMO the main reason Merck and others are interested in DCVax-L is that they are out of option. They see how traumatic it can be as illustrated by the patent expiration of Abbvie's humira if they hit the patent wall" [X Link](https://x.com/d_stock07734/status/1748447671285625167) 2024-01-19T20:49Z [---] followers, [---] engagements "@Jordongf2 @Mionaer1 It is definitive that the approval is incoming. In the ASCO present of last June [---] patients received DCVax-L. In August Les said about [---] patients were treated. Two hundred more patients in less than [--] months. MHRA knows well about the urgency of the approval" [X Link](https://x.com/d_stock07734/status/1748758994108215683) 2024-01-20T17:26Z [---] followers, [---] engagements "@Jordongf2 @Mionaer1 Has anyone wondered about what types of combinations could be used in the UK Specials program The case #1 strikes me as DCVax-L + Poly-ICLC. But it was [--] yrs ago. As shown in the document doctors in UK has the discretion to decide the combinations" [X Link](https://x.com/d_stock07734/status/1748761689351176683) 2024-01-20T17:37Z [---] followers, [--] engagements "@metacollectiveG @FlemmingBruce Agree with you totally. I just love this present from Dr. Liau so much. Anytime I have chance I want to repeat it. These green dots are the immunosuppressive macrophages and plx3397 can prevent monocytes from differentiating into macrophages" [X Link](https://x.com/d_stock07734/status/1749279601392529457) 2024-01-22T03:55Z [---] followers, [----] engagements "@metacollectiveG @FlemmingBruce It strikes me that Dr. Liau already found the roadmap for the cure. All it matters now is to have massive manufacturing facilities ready. I thought as we were approaching the finish line the longs would have more confidence in NWBO. It turns out I was wrong" [X Link](https://x.com/d_stock07734/status/1749280270862152025) 2024-01-22T03:58Z [---] followers, [---] engagements "@exosome @SphereThera Dr. since the paper mentioned about murine model I did some google search and I was amazed by the fact that "dogs and people share over [-----] special genes called orthologs". No wonder Merck and NCI partner with Vetigenics" [X Link](https://x.com/d_stock07734/status/1750771785958604909) 2024-01-26T06:44Z [---] followers, [---] engagements "@SphereThera @exosome Have you by any chance read about this company which is trying to develop a technology to dampen immune response It has something to do with dendritic cell too. Amgen and Gilead fronted big money which from one perspetive reflects how valuable NWBO is" [X Link](https://x.com/d_stock07734/status/1750776583097299426) 2024-01-26T07:03Z [---] followers, [---] engagements "Upstream Senior Scientist - Continuous & Expression Technologies "Develop innovative and disruptive technologies for next-generation large molecule biologic/vaccine manufacturing processes."" [X Link](https://x.com/d_stock07734/status/1752876175347663231) 2024-02-01T02:07Z [---] followers, [---] engagements "Keytruda biosimilar Opdivo biosimilar" [X Link](https://x.com/d_stock07734/status/1753526702267945320) 2024-02-02T21:11Z [---] followers, [---] engagements "@MDendream @dcvaxdaw So discover is a good word that should be encouraging for NWBO shareholders. It means Merck is being serious" [X Link](https://x.com/d_stock07734/status/1753895119894225013) 2024-02-03T21:35Z [---] followers, [----] engagements "@ThomasOwenMcCa1 @metacollectiveG @jhod @MDendream @dcvaxdaw @GoneGoodguy @US_FDA Community Oncology Setting The term sounds familiar. DCVax-L is perfect for community setting" [X Link](https://x.com/d_stock07734/status/1754029412046033118) 2024-02-04T06:29Z [---] followers, [----] engagements "Most importantly the Moonshot program was reinvigorated. Given the extraordinary efficacy of DCVax-L I don't see why DCVax-L cannot play a role in the program. Here is the part taken from the news. It strikes me the Federal Government really have the sense of urgency to get the job done. "Joe Biden is determined to be a president for all Americans. That is why his Unity Agenda is about making progress on the biggest challenges we all face regardless of party" White House deputy chief of staff Bruce Reed added in a statement. "At his direction the entire federal government is mobilizing like" [X Link](https://x.com/d_stock07734/status/1754031653956034567) 2024-02-04T06:38Z [---] followers, [---] engagements "No one knows. As a matter of fact investors don't need to know. All we need to know is how amazing the science is. We can see clearly revolution in bioscience doesn't come often. Abbvie didn't a better alternative to Humira after making $200b in the last [--] years. Neither Merck nor BMY found one to their CIs. All they can do is to make a small change to extend their patents. We can see from the JAMA paper it took on average [--] months to have pseudo-progression resulting from massive t-cell infiltration into tumor sites and there are only three cases intracranial edema caused by" [X Link](https://x.com/d_stock07734/status/1754522571758837942) 2024-02-05T15:09Z [---] followers, [---] engagements "What do you mean we are approaching a binary event Several binary events have already happened. I am surprised you are not aware any of them. No wonder your tone is full of negativity. I did go through your post at ihub. I specifically focused on what's your take on ASCO presentation since you always claim you believe in science. I saw nothing there" [X Link](https://x.com/d_stock07734/status/1754723552824054201) 2024-02-06T04:27Z [---] followers, [---] engagements "Is it possible that each BP can get DCVax-L through franchise and does its own R&D by either combining their own product with DCVax-L or using their expertise in a specific field to explore the full potential of DCVax-L. AZN can combine its PDL-1 inhibitor with DCVax-L. Gilead can do R&D on the application of DCVax-L in antiviral field. Abbvie can use it for autoimmune diseases" [X Link](https://x.com/d_stock07734/status/1755276181857792109) 2024-02-07T17:03Z [---] followers, [--] engagements "Do you have common sense about science Have I mentioned to you that Abbvie didn't find any alternative to humira Neither Merck nor BMY found any good ones to their CIs. So they have to make minor changes to bypass the patent cliff. You think revolution in biotech can come easily as long as BPs start working on it. You are totally wrong. Here is what Dr. Ralph Steinman wanted for anti-tumor response. I wanted as much to initiate a cancer immune response as I wanted to initiate one against infection. There are over [---] clinical trials on dendritic cells. Only DCVax-L can make Steinman's dream a" [X Link](https://x.com/d_stock07734/status/1755442340217459193) 2024-02-08T04:04Z [---] followers, [---] engagements "Here is the figure from Dr. Liau's present. Pink color means t cells which are trying to kill cancer cells (blue color). Those green dots are tumor-associated macrophages. Daichii is the only company which has FDA approved small molecule oral CSF1R inhibitor which can prevent monocytes from differentiating into macrophages. Merck terminated collaboration with Seagen after spending $1.6b on the ADC trials. As for the reason "LV has been shown to be clinically active with a tolerable safety profile however the emerging treatment landscape with newer therapeutics introduces a higher efficacy" [X Link](https://x.com/d_stock07734/status/1755669138347798778) 2024-02-08T19:05Z [---] followers, [--] engagements "I assume everyone knows the story about Keytruda which was not invented by Merck. It was invented by three scientists from the Netherlands. When Merck bought keytruda the research group even had problem getting the funding for further research and Merck put it on shelf. It was because BMY made breakthrough in Opdivo that made Merck jump start keytruda program. If BPs want to step into the empire of dendritic cell vaccine they will find all the possible route has been blocked by the patent wall which LP has been trying to build over many years. One can simply check how many dendritic cell" [X Link](https://x.com/d_stock07734/status/1755816622067990658) 2024-02-09T04:51Z [---] followers, [---] engagements "The correlation between AZN and NWBO is possible and reasonable. @maveric92283613 has mentioned a list of BPs that could strike partnership with NWBO since last year. AZN is one of them. If anyone still has doubt open the following file and search for "AstraZeneca" Or one can simply take a look to see who has close collaboration with the scientists from AstraZeneca. #DISRUPTOR #CANCER $NWBO Collabs: $MRK $AMGN $REGN $BMY $JNJ $GILD $RHHBY $AZN From [--] yr holder Beachhyena (SoCAL) https://t.co/mjd9nr1TK1 AND see reply by [--] yr Doc_Logic: Full agreement $NWBO [--] GEN Wealth: Rockets need FUEL" [X Link](https://x.com/d_stock07734/status/1758226877548818735) 2024-02-15T20:28Z [---] followers, [----] engagements "Here is an abstract from Dr. Liau in which she mentioned about using the technologies to gain a better understanding of the immune cells. Take some of the keywords to see if Merck is trying to recruit people with backgrounds on these technologies. Immunofluorescence [----] University Recruiting - Cambridge Neuroimmunology Cell Biology Co-Op Candidates must have cell staining methods including Immunofluorescence and cell masks or cell structural staining methods Director Global Oncology Precision Medicine - Strategy & Operations The position also requires solid comprehension of business case" [X Link](https://x.com/d_stock07734/status/1758522249240317988) 2024-02-16T16:02Z [---] followers, [---] engagements "Did you realize how toxic the treatment is Patients have to go through intensive chemo so that their immune system can be knocked down before the TIL infusion. Then high-dose interleukin- [--] has to be administered to promote t cell activation. This gave me even more confidence that without doubt FDA is going to approve DCVax-L which has amazing efficacy and nontoxic" [X Link](https://x.com/d_stock07734/status/1759283368242348130) 2024-02-18T18:26Z [---] followers, [--] engagements "I don't see how the market is behaving itself. For MMs fail-to-deliver means they didn't borrow the real shares after [--] working days and their naked shorts become fails-to-deliver. Market makers have special exemptions from the rules: they are allowed to carry a naked short for up to twenty-one trading days before they have to borrow a share. When the share is not borrowed in the allotted time and a buy-in does not occur and they rarely do the naked short becomes a fail-to-deliver (of the borrowed share)" [X Link](https://x.com/d_stock07734/status/1759638774663741881) 2024-02-19T17:59Z [---] followers, [---] engagements "It is interesting that Amgen is also trying to hire people with biomarker expertise. Scientist- Clinical Biomarker Assay Development Scientist Biomarker Discovery Scientific Associate Director Translational Pathology" [X Link](https://x.com/d_stock07734/status/1760514418989781134) 2024-02-22T03:58Z [---] followers, [---] engagements "There will be no BO. All BPs currently have their own approved drugs for cancer. Once DCVax-L (DCVax-L + Poly-ICLC) gets approval BPs can get franchise from NWBO combine DCVax-L with their own drugs run observation study trials just like the platform study currently running in UK and then file for regulatory approval based RWE/RWD. Seems to me it is that simple" [X Link](https://x.com/d_stock07734/status/1761023605003989324) 2024-02-23T13:42Z [---] followers, [---] engagements "@dcvaxdaw @RichFairgrieve That I don't know. I am only concerned about if the trial results are amazing and whether the combination of DCVax-L + Poly-ICLC + Keytruda was adopted. Given the fact that since [----] the UMC Mainz started core research on dendritic cells I would say yes to both possibilities" [X Link](https://x.com/d_stock07734/status/1761165620589084978) 2024-02-23T23:06Z [---] followers, [--] engagements "I have no doubt. Here is the figure from Dr. Liau's presentation which corresponds to the arm in which pd1-inhibitor was given first. In this figure red dots are activated t cells that infiltrated into tumor sites and green dots are macrophages. I asked ChatGpt to count me how many red dots are in the figure. The number is [---] Note that this is a 2d figure and the area must have been magnified a lot for observation purpose. But there are still [---] t cells The base-line for normal person varies between [--] and [--]. Plx3397 will prevent monocytes from differentiating into macrophages which means" [X Link](https://x.com/d_stock07734/status/1763287761082003504) 2024-02-29T19:38Z [---] followers, [---] engagements "The start of hiring frenzy from AZN at Gaithersburg Maryland. Senior Global Study Manager Cell Therapy Oncology R&D Early Clinical Executive Director Head of Virology and Vaccine Research Early V&I Associate Scientist - Bioscience Immunology Senior Scientist Translational Proteomics Global Mass Spectrometry Senior Scientist In Vivo Pharmacology Cell Therapy Associate Director Analytical Cell Therapy Global MS&T Senior Director Oncology Safety Science & Discovery Associate Director Study Leader Cell Therapy Senior Scientist Immuno-Oncology Matan Companies Signs [------] SF Full-Building Lease" [X Link](https://x.com/anyuser/status/1763759193394237828) 2024-03-02T02:52Z [---] followers, [----] engagements "The case study may be about Owain James. The tumor is 14cm only half of it can be removed and three vaccines were made. But with the intense anti-tumor response the remaining half shrank into cyst under continual pounding of the immune system. I suspect that in his case the combination of DCVax-L + poly-iclc + keytruda was adopted" [X Link](https://x.com/anyuser/status/1765155078992715944) 2024-03-05T23:19Z [---] followers, [----] engagements "From the following webpage we can have an idea about the meaning of the nutritional support for the immune system. He is on a host of supplements IV treatments regular hyperbaric oxygen therapy & I am even injecting him [--] times a week with mistletoe therapy. Everything is going well just wanted to provided a quick update; Owain has had [--] DC Vaccines were now doing everything to increase his immune response including Intravenous Vit C Helleborous Artemisinin and an injection of Mistletoe therapy 3x per week. We are working hard to educate ourselves on how to block all the cancer pathways with" [X Link](https://x.com/d_stock07734/status/1765186329799725232) 2024-03-06T01:23Z [---] followers, [--] engagements "In some recent job postings from AstraZeneca cure for cancer was repeatedly mentioned. AstraZeneca's checking point inhibitor even cannot cure all the hot tumors. What could possibly make the company become so ambitious and optimistic that it can provide cures for cancer in every form "AstraZeneca is leading a revolution in cancer care with the ambition to provide cures for cancer in every form following the science to understand cancer and all its complexities to discover develop and deliver life-changing medicines to patients." Senior Director Global Oncology Policy & Advocacy (GI Cancers)" [X Link](https://x.com/d_stock07734/status/1766235743918117137) 2024-03-08T22:53Z [---] followers, [----] engagements "@Cred54675419C Did Pfizer spend $43b acquiring Seagen If mRNA cancer vaccine were so effective I cannot see why Pfizer would spend this huge amount of money on ADC" [X Link](https://x.com/d_stock07734/status/1766591509632049399) 2024-03-09T22:26Z [---] followers, [--] engagements "Here are all the cancer trials run by Moderna or Moderna with Merck or Moderna with AZN. One trial was terminated because of lack of efficacy. Another was cancelled. Simply by taking a look at the outcome measures in those trials and comparing them with the ones adopted in the combo trial we know for sure we are in a universe completely different from the mRNA one. Pay special attention to the following poster. Note CD4 t cells were not mentioned. The yellow dots are CD8 t cells. I cannot see too many yellow dots. I haven't found any other companies which can generate the plots on the number" [X Link](https://x.com/d_stock07734/status/1766608589047685138) 2024-03-09T23:34Z [---] followers, [---] engagements "Our Continuous & Expression Technologies group is looking for creative and innovative scientists/engineers at multiple levels to innovate in upstream process intensification. Out team works closely with Vaccine Process Development partners on exciting new targets and platforms across multiple disease areas (e.g. Infectious Disease and Vaccines Neuroscience). Come join us on our mission to deliver high-quality vaccines to patients Associate Principal Scientist Upstream - Continuous & Expression Technologies Specifically CET is seeking a Principal Scientist specializing in perfusion cell" [X Link](https://x.com/d_stock07734/status/1766636479583809734) 2024-03-10T01:25Z [---] followers, [----] engagements "Amazing picture. Note that this is for DCVax-L only. We haven't seen anything like the case of DCVax-L + poly-iclc or DCVax-L + poly-iclc + Checking point inhibitors. But after signing NDA CEOs and their expert teams can see a lot more amazing stuff. IMO the more color dots over base line the better the results are. In this regard simply take a look at the results that Professor I. Melero obtained from the trial on other solid tumors using his version of dendritic cell vaccine combined with poly-iclc we will have a sense what truly amazing results NWBO has delivered" [X Link](https://x.com/d_stock07734/status/1767224071211647392) 2024-03-11T16:20Z [---] followers, [----] engagements "LP and her team conquered another Mount Everest in technology and filed the application package of 1.7m pages. Yet the net loss of [----] is less than that of [----]. Those who question LP's leadership can stop whining. The special difficulty involved in developing the Flaskworks machine was that unlike other cell types the dendritic cells tightly adhere to the surface of the culture vessel (similar to barnacles). Extracting them from inside the culture vessel without damaging the cells or reducing the yield of doses was extremely challenging. Other cells (including T cells) are generally" [X Link](https://x.com/d_stock07734/status/1767775373201223690) 2024-03-13T04:51Z [---] followers, [---] engagements "These three patients were from the p3 trial. The t cell expansion was measured at 4th and 8th months. I suspect we can assume that these results were obtained at least nine years ago when the enrollment of the p3 trial was finished. There is much more that we haven't seen. Cannot wait to read the paper on the case study mentioned in 10-K" [X Link](https://x.com/d_stock07734/status/1767923073703915806) 2024-03-13T14:38Z [---] followers, [---] engagements "@Nina_kd My wild thinking is that it's no hurt for any BP CEO to sign NDA and take a look at what LP has in the safe. But I don't anticipate LP would show the data on the collaboration trial between NWBO and Merck since Merck wouldn't agree" [X Link](https://x.com/d_stock07734/status/1768124405501108232) 2024-03-14T03:58Z [---] followers, [---] engagements "True. It is interesting to see Mainz installed core facility for mass spectrometry & proteomics of the research center for immunotherapy in [----]. It is even more interesting to read the description of the core research. I heard before in biotech nothing is coincident. The research activities realized at the Institute of Immunology concern various aspects of the induction of innate and adaptive immune responses. As part of our investigations of the innate immune system we analyze the function and regulation of mast cells and neutrophils. Of special interest are the consequences of" [X Link](https://x.com/d_stock07734/status/1769235522470166713) 2024-03-17T05:33Z [---] followers, [---] engagements "AZN bought Fusion for $2.4b. Fusion's therapy targets the most common tumor specific mutant called EFGRvIII. Dr. Liau Nature preprint analyzed the variation of over 19k genes before and after receiving DCVax-L + Poly-ICLC. EFGRvIII is just one of them. It is logic to conjecture that researchers can find other tumor specific mutants so that the therapy can have better precision in attacking cancer cells. https://fusionpharma.com/wp-content/uploads/2023/04/AACR-poster_EGFRvIII_2023_FINAL.pdf" [X Link](https://x.com/anyuser/status/1770634787042038089) 2024-03-21T02:13Z [---] followers, [----] engagements "An interesting job from Merck West Point Campus. Scientist Continuous Manufacturing Technologies - Vaccine Process Development The Continuous & Expression Technologies Group (CET) within the Process Research & Development Enabling Technologies department is seeking motivated and creative individuals who are looking for an opportunity to positively impact our companys manufacturing platforms while actively supporting drug development in the biologics vaccine and small molecule spaces. Specifically CET is seeking Scientists specializing in bioprocessing technologies for vaccine candidates" [X Link](https://x.com/d_stock07734/status/1771247438575128646) 2024-03-22T18:47Z [---] followers, [---] engagements "A very interesting job posting from AZN. My understanding about this job is to use proteomics analysis to find "novel target" for ADC. The target has to be tumor specific which only exists in cancer cells. Which company can provide AZN and other BPs with tumor specific targets The answer is obvious. Is it clear now why all the BPs are trying to acquire ADC companies like crazy "As a Data Scientist in Translational Proteomics you will provide computational support to enable critical proteomics data input for cancer biomarker development. You will support building ADC-target landscape to" [X Link](https://x.com/d_stock07734/status/1771282186534109363) 2024-03-22T21:05Z [---] followers, [----] engagements "We can use Prometheus as an example. The market for UC and CD was $23b in [----]. Merck paid $11b in [----]. The solid tumor market in [----] is $209.6b from the internet. Now I suspect it should be $300b. The price tag should $150b at minimum since the market on antiviral and antibacterial fields and autoimmune diseases are not included and the potential loyalty from licensing neo-peptides found by the use of DCVax-L. Can any BP pay $150b The franchise is a clear signal that there is no BO" [X Link](https://x.com/anyuser/status/1771540965355913320) 2024-03-23T14:14Z [---] followers, [----] engagements "$1b house No doubt jury will have this in their mind when they assess the punitive damages. I hope they also bring to their mind the fact that he spent $43m on the US Constitution. Ken Griffin billionaire CEO of hedge fund Citadel paid $43.2 million for a first-edition copy of the U.S. Constitution at a Sothebys auction. The U.S. Constitution is a sacred document that enshrines the rights of every American and all those who aspire to be Griffin said in a statement. That is why I intend to ensure that this copy of our Constitution will be available for all Americans and visitors to view and" [X Link](https://x.com/d_stock07734/status/1771754430120988785) 2024-03-24T04:22Z [---] followers, [---] engagements "AZN is looking for Senior Scientist Oncology TTD Target Discovery Gaithersburg MD. It seems like the job is about finding the new targets for its ADCs. I suspect there is now an much better and efficient way in finding new targets. "This is your chance to join our Tumor Targeted Delivery team in Early Oncology in Gaithersburg MD USA. As a Senior Scientist you will lead target validation efforts for tumor-targeted therapies such as antibody-drug-conjugates (ADCs) and targeted radio-conjugates." "As a Senior Scientist you will act as target validation lead for one or more pipeline programs. You" [X Link](https://x.com/d_stock07734/status/1772002043470762248) 2024-03-24T20:46Z [---] followers, [---] engagements "Merck Others Look to Immunotherapy Combos as Next Frontier in Oncology We are moving toward a future where we have enough medications that each work individually and have minimal side effects so that we can create even larger combinations which offer the most benefit to people said David Weinstock vice president of discovery oncology at Merck whose blockbuster immunotherapy Keytruda is a go-to for such combos. Keytruda's main function is to unmask t cells so that they can recognize cancer cells. It only works under the condition that t cells are around cancer cells. If there are no t cells" [X Link](https://x.com/anyuser/status/1772293357319946694) 2024-03-25T16:03Z [---] followers, [----] engagements "Interesting answers from ChatGPT on how dendritic cells can help in identifying tumor specific targets for ADCs. Here's how dendritic cells can contribute to identifying tumor-specific targets for ADCs: Antigen Presentation: Dendritic cells capture antigens including those from tumor cells through various mechanisms such as phagocytosis receptor-mediated endocytosis or cross-presentation. Tumor-specific antigens presented by dendritic cells can potentially be targeted by ADCs. Screening Assays: Researchers can utilize dendritic cells in screening assays to identify antigens that are" [X Link](https://x.com/d_stock07734/status/1773066147446890879) 2024-03-27T19:14Z [---] followers, [----] engagements "Size exclusion chromatography (SEC) is the analytical gold standard for the separation and accurate quantitation of aggregates monomers and lower molecular weight fragments contained in biotherapeutic peptides and proteins including monoclonal antibody (mAbs) drugs. Did Dr. Liau use SEC in her research Sure did. "For enzyme assays using recombinant IDH1 enzyme proteins were purified from E coli using Ni affinity and size-exclusion chromatography." The interesting part is that all these BPs are recruiting people with skills on SEC. Merck Principal Scientist Biologics Analytical Research &" [X Link](https://x.com/d_stock07734/status/1773921171521581263) 2024-03-30T03:52Z [---] followers, [----] engagements "@BIO99_BIO99 @sharpie510 Abbvie may have read the paper by now. On the webpage which was set up on January [--] [----] according to Wayback Machine the word "cure" is everywhere. https://www.abbvie.com/science/the-case-for-big-bets.html https://www.abbvie.com/science/the-case-for-big-bets.html" [X Link](https://x.com/d_stock07734/status/1774127599754637822) 2024-03-30T17:32Z [---] followers, [---] engagements "If we believe we are embracing something revolutionary we have to dream big. They are trying to build another Silicon Valley in immunology. The acquisition of HCA hospital approved by the University of California Board of Regents was done. There are going to be a lot of clinical trials. Is the University of California Board of Regents also the owner of some of the DCVax-L patents UCLAs goal is to build the immunology equivalent of Silicon Valley in Los Angeles said Mazziotta. Given the universitys expertise and state-of-the-art facilities we are expecting to attract the worlds best scientists" [X Link](https://x.com/d_stock07734/status/1776047085315350860) 2024-04-05T00:39Z [---] followers, [----] engagements "Another deal on ADC. Seriously have we seen a single BP which hasn't had ADC in its portfolio. ADCs are bio missiles and IMO to make missiles hit targets--the cancer cells with high precision while leaving intact the healthy cells the precise target identification is the key. All the current ADCs are using pretty much the same targets. They will have a lot more if they use DCVax-L as a tool for target identification" [X Link](https://x.com/d_stock07734/status/1776282903124611594) 2024-04-05T16:17Z [---] followers, [---] engagements "The interesting part is that this issue of Nature Outline was sponsored by Moderna. It has sort of commercial advertisement article by Moderna. But Nature presented two articles to give the audience a whole picture on cancer vaccine. I have to repeat this again. Look the number of tumor-associated peptides presented by MHC Class II molecules. No other companies on this planet can reach this breakthrough. I once picked up the peptide IDs listed in the figure and did the search in peptide database. No match cannot be found which means thy were unknown to human being before the ASCO presentation" [X Link](https://x.com/d_stock07734/status/1776659162555924589) 2024-04-06T17:12Z [---] followers, [----] engagements "On Tuesday April [--] Rathmell will join a representative from the White House and other panelists to discuss the latest on President Joe Bidens Cancer Moonshot initiative. This major symposium The Cancer Moonshot: Opportunities to Fulfill the Vision of the National Cancer Plan will be held from 2:30 [--] p.m. PT in Room [--] on the upper level of the convention center. The Cancer Moonshot: Opportunities to Fulfill the Vision of the National Cancer Plan - Dedicated to the Memory of Senator Dianne Feinstein Description The Reignited Cancer Moonshot launched by President Biden seeks to mobilize" [X Link](https://x.com/d_stock07734/status/1776845492204281923) 2024-04-07T05:32Z [---] followers, [----] engagements "@TimThomas0007 @apwriter It is a possible scenario which explains why Oncovir has on board a legal consultant with expertise on acquisition and exit in June [----]. https://www.oncovir.com/pusch-b https://www.oncovir.com/pusch-b" [X Link](https://x.com/d_stock07734/status/1776970779306901530) 2024-04-07T13:50Z [---] followers, [----] engagements "Can we expect the exciting data on rGBM now since data on prostate caner is out "Our T cell expansion and tumor infiltration story is supported by additional data coming out in the next few weeks." President and Chief Operating Officer Matthew Vandermast highlighted the key attributes of Hiltonol a synthetic dsRNA designed to activate the bodys defense mechanisms against viruses and tumors. Oncovirs clinical targets are solid tumors and infectious disease indications including HIV and COVID. We have especially exciting data developing around recurrent glioblastoma and prostate cancer." [X Link](https://x.com/anyuser/status/1778569691486634244) 2024-04-11T23:43Z [---] followers, [----] engagements "I don't know about CAR-T and I don't know the actual value of $NWBO either. Here Abbvie paid $10b for a company which only had one FDA approved drug for ovarian cancer treatment one year ago. $NWBO technology can treat all solid tumors. So at minimum $150b. But now with all the new input from RevImmune on HIV and other cancers even this number seems low. It seems like no BP can afford $NWBO. AbbVie pays $10B to acquire ImmunoGen doubling down on red-hot ADC cancer field https://www.fiercepharma.com/pharma/abbvie-pays-10b-acquire-immunogen-doubling-down-red-hot-adc-cancer-field" [X Link](https://x.com/d_stock07734/status/1783336871671504912) 2024-04-25T03:26Z [---] followers, [---] engagements "@maveric92283613 Almost all the BPs have record revenue and in the meantime they all have massive layoffs including R&D to optimize prioritize and streamline their pipeline. As you mentioned before there is no coincidence" [X Link](https://x.com/d_stock07734/status/1783481589155987964) 2024-04-25T13:02Z [---] followers, [--] engagements "@apwriter The interesting part is that Athenahealth is a private company. https://www.techtarget.com/searchhealthit/news/366578802/EHR-Vendor-athenahealth-Acquired-by-Hellman-Friedman-Bain-Capital https://www.techtarget.com/searchhealthit/news/366578802/EHR-Vendor-athenahealth-Acquired-by-Hellman-Friedman-Bain-Capital" [X Link](https://x.com/d_stock07734/status/1788261829417824268) 2024-05-08T17:36Z [---] followers, [--] engagements "Note that NWBO licensed the DC vaccine technology. Competing interests Andres Salazar is the Founder CEO and Scientific Director for Oncovir which provided the TLR agonist (Poly-ICLC) used in the trial. Linda M. Liau is a member of the Scientific Advisory Board for Northwest Bioetherapeutics Inc which has licensed the DC vaccine technology. All others declare no competing interests" [X Link](https://x.com/anyuser/status/1788281609046630488) 2024-05-08T18:55Z [---] followers, [----] engagements "We have a drug master file with the FDA and we have been in front of many of the worlds tier [--] regulatory agencies including the European Union Countries including France and Switzerland in addition to Canada Japan Brazil and Thailand. Our product is going to be able to be used around the world. Our big push is to get funding so that we can support the development of Hiltonol with our partners and get commercialized in one therapeutic area. https://gritdaily.com/cancer-therapy-oncovirs-hiltonol/ https://gritdaily.com/cancer-therapy-oncovirs-hiltonol/" [X Link](https://x.com/anyuser/status/1788324993547300950) 2024-05-08T21:47Z [---] followers, [----] engagements "Use cell + oncology to search AZN job website there are [---] recent openings. https://careers.astrazeneca.com/search-jobs/cell%20%2B%20oncology/7684/1glat=30.51685905456543&glon=-86.48217010498047 https://careers.astrazeneca.com/search-jobs/cell%20%2B%20oncology/7684/1glat=30.51685905456543&glon=-86.48217010498047" [X Link](https://x.com/d_stock07734/status/1789018079873179992) 2024-05-10T19:42Z [---] followers, [---] engagements "@apwriter Remind Roaring Kitty this billionaire is also a short seller of $NWBO. https://www.afr.com/companies/media-and-marketing/short-selling-media-company-long-odds-for-australia-20240407-p5fhyy https://www.afr.com/companies/media-and-marketing/short-selling-media-company-long-odds-for-australia-20240407-p5fhyy" [X Link](https://x.com/d_stock07734/status/1790503855920119894) 2024-05-14T22:05Z [---] followers, [---] engagements "@dcvaxdaw @JPGarza84 @metacollectiveG They don't have leverage either. If they can get call options they will lose less. Did I get that right" [X Link](https://x.com/d_stock07734/status/1790619641443709033) 2024-05-15T05:46Z [---] followers, [---] engagements "@patrickwalsh14 I suspect Madoff let his sons to turn him in" [X Link](https://x.com/d_stock07734/status/1791171231611273576) 2024-05-16T18:17Z [---] followers, [--] engagements "MGMT is fabulous. It is a nonarugable fact. Did the Nature paper specifically mention that the technology employed was licensed by the company It used to be the norm that the company presented something at the Industry Expert Theater. I suspect they cannot do that this year because of pending approval" [X Link](https://x.com/d_stock07734/status/1791498935598518710) 2024-05-17T16:00Z [---] followers, [--] engagements "This figure is one of my favorite from Dr. Liau's present. The green dots are tumor-associate macrophages coming to tumor site to suppress t cells which are the red dots. Have you checked some of the papers on how effectively plx3397 can deplete tumor-associate macophages I read some and it seems to me plx3397 as the only FDA approved oral CSF1R-I is highly effective. Imagine what would happen to those blue dots (cancer cells) if all the green dots are gone. Also the colorectal cancer also has immunosuppressive characteristic dominated by tumor-associated macrophages" [X Link](https://x.com/d_stock07734/status/1791675555135225875) 2024-05-18T03:41Z [---] followers, [---] engagements "Qurient has the technology for the orally available immuno-oncology therapeutic small molecule targeting selectively Axl Mer and CSF1R originated from the Max Planck Institute of Biochemistry. The small molecule drug called Q702 is an orally available selective Axl/Mer/CSF1R triple kinase inhibitor showing significant in vivo activity as monotherapy as well as in combination with anti-PD-1 antibody. Q702 not only modulates innate immune components such as myeloid derived suppressor cell tumor associated macrophage in tumor micro-environment but also increases MHC I expression in tumor cell." [X Link](https://x.com/d_stock07734/status/1794104024293114018) 2024-05-24T20:31Z [---] followers, [---] engagements "@olblue26 @Alex29617214 Well in this case for this particular you do need to appreciate. LP brought this company back from the verge of bankruptcy. If the management is garbage why are you still hanging around Find a greener pasture" [X Link](https://x.com/d_stock07734/status/1795488778276024648) 2024-05-28T16:14Z [---] followers, [---] engagements "Naysayers keep saying that the collaboration trial on colorectal cancer between $NWBO and $MRK was cancelled and never happened. IMO the trial is real and most like the results must be great. Why The trial was still listed as one of research projects on the webpage of Johannes Gutenberg-Universitt Mainz in [----] the same year of the completion of the research project. More importantly based on the disclosure on the conflict of interest over the past ten years the PI of the trial professor Markus Moehler has been in close collaboration with Merck (MSD). There was no overlapping between him and" [X Link](https://x.com/anyuser/status/1795886661412213037) 2024-05-29T18:35Z [---] followers, [----] engagements "@dcvaxdaw I suspect the [--] pts are for a company with mediocre science and definitely are not measures for an OTC company with revolutionary and disruptive science. It is just that simple" [X Link](https://x.com/d_stock07734/status/1796588678254559323) 2024-05-31T17:04Z [---] followers, [--] engagements "@andrewcaravello Great stuff Andrew. I found one interesting sentence about in-situ vaccine. Does Direct fall into the category of in-situ vaccine https://www.nature.com/articles/d41586-024-01429-2 https://www.nature.com/articles/d41586-024-01429-2" [X Link](https://x.com/d_stock07734/status/1796623154527240601) 2024-05-31T19:21Z [---] followers, [---] engagements "Trials on ADCs neoantigen therapy and small molecule drugs can have the risk of failure. DCVax-L has no such problems. Are the dendritic cells trained and educated by NWBO technology picky about the lysate types from different solid tumors I don't think so. Otherwise NWBO would have filed different patents for different solid tumors. One interesting thing about the collaboration trials between Merck and Moderna is that keytruda shows efficacy for all those targets in the collaboration trials and has FDA approval for those targets. They just want to see to what extent the efficacy will improve" [X Link](https://x.com/d_stock07734/status/1798152461854581215) 2024-06-05T00:38Z [---] followers, [----] engagements "I don't think there will be p3 trial any more for DCVax-L. You can see Moderna is planning for approval based on a phase [--] trial. I don't see any reason NWBO cannot do the same. As for $20b or $80b how about going through what happened to the acquisition of Prometheus first Then give an estimate about NWBO. https://s21.q4cdn.com/488056881/files/doc_presentations/2023/04/Splash-Investor-Event-Slides-FINAL-1.pdf https://s21.q4cdn.com/488056881/files/doc_presentations/2023/04/Splash-Investor-Event-Slides-FINAL-1.pdf" [X Link](https://x.com/d_stock07734/status/1799959836475396377) 2024-06-10T00:20Z [---] followers, [---] engagements "From ChatGPT about proteomics on antigen-presenting cells. A full proteomics analysis of antigen-presenting cells (APCs) can be quite time-consuming. The detailed steps involved and their associated time requirements are as follows: Sample Collection and Preparation: Cell Isolation: Isolating APCs (such as dendritic cells macrophages or B cells) from tissues or cell cultures can take several hours to a couple of days depending on the starting material and isolation method (e.g. flow cytometry sorting magnetic-activated cell sorting). Protein Extraction and Digestion: This involves lysing the" [X Link](https://x.com/d_stock07734/status/1800941986028871882) 2024-06-12T17:23Z [---] followers, [----] engagements "@dcvaxdaw @alphavestcap Management did a fabulous job last year. Before the approal sp is the least we should care about. So Yes for all items" [X Link](https://x.com/d_stock07734/status/1801076159524012404) 2024-06-13T02:16Z [---] followers, [--] engagements "I don't see how comparison can be made between the two. NWBO has been keeping such a low profile for many years and yet has been under constant attack. Recall two Harvard professors became so desperate that they abandoned their ethics and wrote a hitting piece published on Thanksgiving day. The piece had such a poor quality that they had to make correction later. Put your trust in the management. They are the ones who have been guarding NWBO and reached one milestone after another. Again how many years has Dr. Liau been collaborating with NWBO management Over [--] years. I am certain Dr. Liau" [X Link](https://x.com/d_stock07734/status/1801291239481917849) 2024-06-13T16:31Z [---] followers, [---] engagements "@escctrl74 I voted the same. Even though I am a minnow I am so proud of swimming along with big whales" [X Link](https://x.com/d_stock07734/status/1801375204293120363) 2024-06-13T22:04Z [---] followers, [---] engagements "@dcvaxdaw @olblue26 @metacollectiveG @justinkeister5 @tbinfo1 @maveric92283613 @ThomasOwenMcCa1 Are you serious Which part makes you think the company in crisis The company is perfectly fine. Everyone is waiting for the approval which will trigger chain reaction" [X Link](https://x.com/d_stock07734/status/1801448266858430649) 2024-06-14T02:55Z [---] followers, [---] engagements "Since I am a half-full type of person. I would say SIO is a greedy friend. Does Labcorp account for the largest percentage in SIO's portfolio Labcorp is in the field similar to that of CRL. The company created a spin-off specifically focusing on CRO. SIO just reinvested in a company which is developing small molecule inhibitor to over immunosuppression. It seems like SIO is serious in Oncology. Why did SIO not buy C-shares I suspect LP didn't give SIO the option. 8m is the maximum number LP can offer. If SIO is a true believer in DCVax-L SIO has to load in the open market. Loaning out all the" [X Link](https://x.com/d_stock07734/status/1801647661365203427) 2024-06-14T16:07Z [---] followers, [--] engagements "@dcvaxdaw @tbinfo1 @metacollectiveG @ABenS2060 @ThomasOwenMcCa1 @justinkeister5 I found the post. I thought you would have read it carefully. But it seems like you were in a hurry to utter your opinion about how you were going to vote. https://x.com/d_stock07734/status/1795886661412213037t=0jLbKdZye-CsPYzf5Sy0Fw&s=19 Naysayers keep saying that the collaboration trial on colorectal cancer between $NWBO and $MRK was cancelled and never happened. IMO the trial is real and most like the results must be great. Why The trial was still listed as one of research projects on the webpage of" [X Link](https://x.com/d_stock07734/status/1801749461665775651) 2024-06-14T22:52Z [---] followers, [---] engagements "This is the trial that just started earlier this year. The clinical trial is led by Dr. Puzanov principal investigator with Pawel Kalinski MD PhD Chair Department of Immunology Chief of Translational Immuno-Oncology and Senior Vice President for Team Science at Roswell Park as laboratory lead. Dr. Kalinski also is the holder of a five-year $14.5 million National Cancer Institute-funded Program Project Grant involving Roswell Park the University of Pittsburgh Medical Center and Mt. Sinai School of Medicine that has led to the development of this form of immunotherapy for melanoma breast" [X Link](https://x.com/d_stock07734/status/1802714835295129672) 2024-06-17T14:48Z [---] followers, [----] engagements "Pfizers Gene Therapy for Duchenne Muscular Dystrophy Fails Phase III Trial https://www.biospace.com/article/pfizer-s-gene-therapy-for-duchenne-muscular-dystrophy-fails-phase-iii-trial/ https://www.biospace.com/article/pfizer-s-gene-therapy-for-duchenne-muscular-dystrophy-fails-phase-iii-trial/" [X Link](https://x.com/d_stock07734/status/1802793083861651862) 2024-06-17T19:59Z [---] followers, [---] engagements "Absolutely. For instance dendritic cells can be educated to treat HIV. The vaccine candidate is developed by the Vaccine Research Institute (VRI) with LinKinVax technology the first vaccine based on this technology targeting an immune response binding HIV envelope protein to monoclonal antibodies specifically targeting CD40 receptors on dendritic cells. The Env protein is injected and delivered directly to the dendritic cells. The vaccine is combined with the Hiltonol adjuvant designed to enhance its potential action. Professor Yves Lvy Executive Director of the VRI and CMSO of LinKinVax" [X Link](https://x.com/d_stock07734/status/1803183292058919067) 2024-06-18T21:49Z [---] followers, [---] engagements "@peter_brit @justinkeister5 Thank you for being the inexhaustible source of information on NWBO. I didn't realize LabCorp had very high-caliber board members. The new board member is also on Merck's board. It is really a small world https://ir.labcorp.com/corporate-governance/board-of-directors https://ir.labcorp.com/news-releases/news-release-details/labcorp-appoints-dr-paul-rothman-board-directors https://ir.labcorp.com/corporate-governance/board-of-directors https://ir.labcorp.com/news-releases/news-release-details/labcorp-appoints-dr-paul-rothman-board-directors" [X Link](https://x.com/d_stock07734/status/1803483063776583726) 2024-06-19T17:40Z [---] followers, [----] engagements "Dr. W. Kimryn Rathmell mentioned about pediatirc Ewing sarcoma. NCI did a trial using dendritic cell vaccine in combination with CYT107 eight years ago and the results are truly amazing. Previous Cancer Moonshot SM investments supported the Fusion Oncoprotein in Childhood Cancer Consortium which identified a new therapeutic target for Ewing sarcoma. https://www.cancer.gov/about-nci/budget/congressional-justification/fy2025-nci-congressional-justification.pdf https://clinicaltrials.gov/study/NCT00923351" [X Link](https://x.com/d_stock07734/status/1803996531051118878) 2024-06-21T03:41Z [---] followers, [----] engagements "AbbVie's Humira loses some ground in high-stakes battle against biosimilars: report https://www.fiercepharma.com/pharma/shrinking-market-share-abbvies-humira-loses-ground-battle-against-biosimilars-report https://www.fiercepharma.com/pharma/shrinking-market-share-abbvies-humira-loses-ground-battle-against-biosimilars-report" [X Link](https://x.com/d_stock07734/status/1811869056661639656) 2024-07-12T21:03Z [---] followers, [---] engagements "Here is the part from NWBO's PR on the challenge of isolating adherent dendritic cells without damage. The special difficulty involved in developing the Flaskworks machine was that unlike other cell types the dendritic cells tightly adhere to the surface of the culture vessel (similar to barnacles). Extracting them from inside the culture vessel without damaging the cells or reducing the yield of doses was extremely challenging. Other cells (including T cells) are generally cultured suspended in liquid in a bag which makes it much easier to move them through processes. Many companies have" [X Link](https://x.com/anyuser/status/1812862341500870762) 2024-07-15T14:50Z [---] followers, [----] engagements "Amgen BMS and Merck have the most exposure as Big Pharma eyes $183B patent cliff: analyst https://www.fiercepharma.com/pharma/firepower-aplenty-and-patent-cliffs-ahead-time-right-ma-activity-report https://www.fiercepharma.com/pharma/firepower-aplenty-and-patent-cliffs-ahead-time-right-ma-activity-report" [X Link](https://x.com/d_stock07734/status/1813036011435229425) 2024-07-16T02:20Z [---] followers, [---] engagements "Were curing people of diseases that we previously thought were absolutely intractable and not survivable said Karen Knudsen CEO of the American Cancer Society and the American Cancer Society Cancer Action Network. GBM is the most commonand most aggressivetype of cancerous brain tumor in adults. Individuals with GBM usually expect to live 12-18 months following their diagnosis. Despite decades of research there is no known cure for GBM and approved treatmentssuch assurgery radiation and chemotherapyhave limited effect in prolonging an individuals life expectancy. However even after aggressive" [X Link](https://x.com/d_stock07734/status/1823369434557280641) 2024-08-13T14:42Z [---] followers, [---] engagements "@maxstradamus21 I suspect this is what platform technology is about. I have not included the value from supplying neo-peptides that can trigger antitumor immune response. Note that only far less 1% neo-peptides can trigger antitumor immune response" [X Link](https://x.com/d_stock07734/status/1824199912830951675) 2024-08-15T21:42Z [---] followers, [---] engagements "@peter_brit @nipomo357 There is a possibility that some way this could be related to DCVax-L. Whttps://www.onclive.com/view/roswell-parks-dr-pawel-kalinski-to-lead-145m-ncifunded-immunotherapy-effort https://oncology.labcorp.com/cancer-care-team/news-events/labcorp-expands-oncology-portfolio-omniseqr-acquisition https://www.biospace.com/roswell-park-cancer-institute-spins-off-b-omniseq-b-genomics-firm https://oncology.labcorp.com/cancer-care-team/news-events/labcorp-expands-oncology-portfolio-omniseqr-acquisition" [X Link](https://x.com/d_stock07734/status/1824804073641558217) 2024-08-17T13:42Z [---] followers, [---] engagements "@maveric92283613 @LuckyPenguin10 @biggercapital And look at which company is collaborating with $CLPT. https://www.amplify-bio.com/cns-drug-delivery-at-amplifybio/ https://www.amplify-bio.com/cns-drug-delivery-at-amplifybio/" [X Link](https://x.com/d_stock07734/status/1824884506945319193) 2024-08-17T19:02Z [---] followers, [---] engagements "How many companies like Genentech will strike a franchise agreement with NWBO I suspect the technology must be so amazing. Otherwise they would not abandon their early-stage R&D. "How is Amgen using human genetic data to improve drug discovery and design Bradway observed that Amgen is the largest company using human genetic data to inform drug development thanks in large part to our deCODE genetics subsidiary. He explained the importance of this data by noting that even when candidate medicines show promise in preclinical research with non-human animals those models don't always replicate how" [X Link](https://x.com/d_stock07734/status/1825651538695446909) 2024-08-19T21:50Z [---] followers, [----] engagements "@dcvaxdaw That was hilarious Have a great weekend" [X Link](https://x.com/d_stock07734/status/1827081022296539528) 2024-08-23T20:30Z [---] followers, [--] engagements "McKesson Signs Agreement to Acquire Controlling Interest in Florida Cancer Specialists & Research Institutes Core Ventures https://investor.mckesson.com/news/financial-news/2024/McKesson-Signs-Agreement-to-Acquire-Controlling-Interest-in-Florida-Cancer-Specialists--Research-Institutes-Core-Ventures/default.aspx https://investor.mckesson.com/news/financial-news/2024/McKesson-Signs-Agreement-to-Acquire-Controlling-Interest-in-Florida-Cancer-Specialists--Research-Institutes-Core-Ventures/default.aspx" [X Link](https://x.com/d_stock07734/status/1828050336130453793) 2024-08-26T12:42Z [---] followers, [---] engagements "Another round of layoff from Genentech and scientists are the layoff targets. Scientist roles will be the hardest hit per the filing but the layoff round will also include engineers managers analysts and one vice president. That research hasnt been fruitful for the biotech company the outlet reported failing to replicate the success of blockbuster Genentech cancer drugs like Avastin Rituxan and Herceptin. One week ago Genentech shut down cancer immunology research department. I suspect Genentech must have a clear idea about its future first before letting go its most valuable assets. The" [X Link](https://x.com/d_stock07734/status/1828626794183848400) 2024-08-28T02:52Z [---] followers, [----] engagements "Illumina already sells a laboratory developed test for profiling cancer called TSO [---]. The product which targets [---] genes in tissue samples generated sales of more than $100 million in [----] Illumina CEO Jacob Thaysen said on an earnings call in February. Thaysen said the test was expected to have high double-digit growth into this year and we dont see any end to that right now. https://www.illumina.com/content/dam/illumina/gcs/assembled-assets/marketing-literature/tso-comp-us-datasheet-m-amr-01466/trusight-oncology-comprehensive-us-data-sheet-m-amr-01466.pdf" [X Link](https://x.com/d_stock07734/status/1829023744351760452) 2024-08-29T05:10Z [---] followers, [---] engagements "@mightynio I have no clue about BNGO. Right now Illumina mentioned about about five hundred genes that are related to tumor. What I am curious about is that how soon the company is going to add more How could the company identify those mutated genes efficiently in the future" [X Link](https://x.com/d_stock07734/status/1829157298050347136) 2024-08-29T14:00Z [---] followers, [---] engagements "@maveric92283613 @escctrl74 Another Volkswagen short squeeze Probably even bigger one" [X Link](https://x.com/d_stock07734/status/1829221034102272397) 2024-08-29T18:14Z [---] followers, [---] engagements "Did you the following figure All sorts of immune cells were activated. The percentage of CD4 is higher than that of CD8. CD14 monocyte which would differentiate into tumor-associated macrophages and suppress anti-tumor immune response also accounts for a significant percentage. But CSF1R-I can inhibit the differentiation. NWBO has the technology that can cure the most difficult cancer" [X Link](https://x.com/d_stock07734/status/1830085822751625528) 2024-09-01T03:30Z [---] followers, [----] engagements "The comment period on the draft of Platform Technology Designation Program for Drug Development ends on August [--] 2024" [X Link](https://x.com/d_stock07734/status/1830419664838512766) 2024-09-02T01:37Z [---] followers, [---] engagements "Were working to invent a world where cancer isnt just treated but cured or even where some types are prevented from happening in the first place. According to waybackmachine the above was added on August [--] [----]. https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/ https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/ https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/" [X Link](https://x.com/d_stock07734/status/1831366734995189946) 2024-09-04T16:20Z [---] followers, [---] engagements "@apwriter Keytruda biosimilar is on the way. https://www.pharmaceutical-technology.com/data-insights/pembrolizumab-biosimilar-sandoz-group-melanoma-likelihood-of-approval/ https://www.lexology.com/library/detail.aspxg=37efda82-adde-46fa-a1af-ef53c48d6b8b https://www.clinicaltrialsarena.com/news/samsung-biopeis-keytruda-biosimilar-enters-phase-iii-trials/ https://www.pharmaceutical-technology.com/data-insights/pembrolizumab-biosimilar-sandoz-group-melanoma-likelihood-of-approval/ https://www.lexology.com/library/detail.aspxg=37efda82-adde-46fa-a1af-ef53c48d6b8b" [X Link](https://x.com/d_stock07734/status/1831403142745092145) 2024-09-04T18:45Z [---] followers, [---] engagements "The potential is far beyond cancers. DCVax-L could be the key to treating most diseases. Can NWBO's technology educate and prime dendritic cells so that they can command immune cells to eliminate mutated genes that cause hear diseases and Alzheimer's It is possible. Can NWBO's technology identify the targets on super bugs that can be loaded on ADCs to treat bacterial infection In my wild thinking there is a possibility too. Immunology is the mediator of nearly all human diseases whether were talking about cancer or heart disease or Alzheimers Michelson said. The vision for this institute is" [X Link](https://x.com/d_stock07734/status/1831776536933937225) 2024-09-05T19:28Z [---] followers, [----] engagements "@StonkMasterJ Patients with [--] types of cancers were treated through compassionate use program. "Most of them blockbuster drugs". Up to now most likely over one thousand GBM patients have received the treatments. And you are trying to put a price tag on such company. You cannot be serious" [X Link](https://x.com/d_stock07734/status/1831785563546120292) 2024-09-05T20:04Z [---] followers, [---] engagements "SC Tecentriq from Roche is checking point inhibitor. Roche had the approval from UK EU Canada already. BMS has the PDUFA of their SC Opdivo on December [--]. Merck hasn't finished its clinical trials yet. Actually Merck did finish one. But Merck never publicized the results and the media has already questioned about it. I suspect pressure is mounting on Merck. https://www.barrons.com/articles/merck-stock-keytruda-cancer-trial-07d2979f https://www.barrons.com/articles/merck-stock-keytruda-cancer-trial-07d2979f" [X Link](https://x.com/d_stock07734/status/1833191834538934579) 2024-09-09T17:12Z [---] followers, [---] engagements "Genentech's cancer restructure was made 'for scientific reasons': exec https://www.fiercebiotech.com/biotech/genentechs-cancer-restructure-was-made-scientific-reasons-execs https://www.fiercebiotech.com/biotech/genentechs-cancer-restructure-was-made-scientific-reasons-execs" [X Link](https://x.com/d_stock07734/status/1833610182833602992) 2024-09-10T20:55Z [---] followers, [----] engagements "@patrickwalsh14 @DonDonjarvis101 @smith348572 @JAMA_current The other BPs are also going to hit patent cliff in four years. NWBO is not a company that Merck can afford now" [X Link](https://x.com/d_stock07734/status/1833626345404043292) 2024-09-10T21:59Z [---] followers, [---] engagements "It is the technology that they can use "to build the immunology equivalent of Silicon Valley in Los Angeles" A first-of-its kind effort in California the nonprofit public-private partnership will leverage UCLAs existing strengths in clinical and biomedical scientific research across a range of disciplines. Top-flight scientists from UCLA and around the world will pursue new tools treatments and vaccines to address a variety of pressing health challenges including cancer infectious diseases allergies autoimmune disorders heart conditions immune factors associated with organ transplantation and" [X Link](https://x.com/d_stock07734/status/1834310200913994143) 2024-09-12T19:16Z [---] followers, [---] engagements "@Hspooner665 See what kind of trials the company is running Is that interesting I think the therapy targets a specific gene called TNF. I could be wrong. https://www.inmunebio.com/index.php/newsroom/2024-news/muneioncnnouncesewhase1tudyataemonstrati20240729060507 https://www.clinicaltrialsarena.com/news/inmune-bios-unique-alzheimers-trial-endpoint-receives-validation/ https://www.inmunebio.com/index.php/newsroom/2024-news/muneioeportsignificantmprovementinlzheimer20240305050502 https://www.inmunebio.com/index.php/newsroom/2024-news/muneioncnnouncesewhase1tudyataemonstrati20240729060507" [X Link](https://x.com/d_stock07734/status/1834322864469856453) 2024-09-12T20:07Z [---] followers, [---] engagements "To have a BO you have to put a price tag. How could you price something with unlimited potential As an illustration in ASCO presentation Dr. Bosch mentioned that peptides from viruses were also presented to the immune system. But he didn't mention if the viruses were eliminated. What if the current DCVax-L technology (maybe with some modifications) can treat infectious diseases like HIV or neurodegenerative diseases like Alzheimer's How could you handle the BO pricing about these two types of diseases New vaccine targeting toxic amyloid- could help halt Alzheimers disease progression" [X Link](https://x.com/d_stock07734/status/1834609706783936686) 2024-09-13T15:06Z [---] followers, [--] engagements "@jman4956 @RBioceutics I doubt if anyone knows the answer. I wonder if this news has something to do with DCVax-L. If it does no way can someone assign a number to the value of NWBO. https://newsroom.ucla.edu/stories/ucla-research-park-immunology-and-immunotherapy https://newsroom.ucla.edu/stories/ucla-research-park-immunology-and-immunotherapy" [X Link](https://x.com/d_stock07734/status/1835024911749824851) 2024-09-14T18:36Z [---] followers, [---] engagements "@TiltMyBrain Different tumors could have different immunosuppressive characteristics. We need an extra inhibitor to take care of immunosuppresion. We all know this for a fact. But I never feel tired of repeating it" [X Link](https://x.com/d_stock07734/status/1836854013209325986) 2024-09-19T19:44Z [---] followers, [---] engagements "@MDendream I get my champagne ready for the fireworks show in a month. You are saying it will be next year. Don't burst my bubble" [X Link](https://x.com/d_stock07734/status/1837124643448119752) 2024-09-20T13:40Z [---] followers, [---] engagements "The following are all the dendritic cell clinical trials sponsored by DoD. It seems like they all are connected to NWBO in some way. Did LP mention at ASM that NWBO has collaboration with academic institutions other than Roswell Park A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) Principal Investigator:Peter A Forsyth MDMoffitt Cancer Center Innovative Dendritic Cell Vaccine Trial Provides Hope for Breast Cancer Patients with Leptomeningeal Disease Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast" [X Link](https://x.com/anyuser/status/1837204138267976027) 2024-09-20T18:56Z [---] followers, [----] engagements "A doctor journeys from still rings to brain tumors Dr. Robert Prins steps into the U Magazine spotlight. https://www.uclahealth.org/news/publication/doctor-journeys-still-rings-brain-tumors https://www.uclahealth.org/news/publication/doctor-journeys-still-rings-brain-tumors" [X Link](https://x.com/d_stock07734/status/1837205272101601403) 2024-09-20T19:00Z [---] followers, [---] engagements "@GoldwaterF98498 In addition to cure cancer I picture in [--] years DCVAX-L technology will put a bio-valley at UCLA in good shape. The technology will be the fundamental platform used for the development of drugs and vaccines for both humans and mammals" [X Link](https://x.com/d_stock07734/status/1837617897939612093) 2024-09-21T22:20Z [---] followers, [--] engagements "Is there another cancer vaccine better than DCVax-L which can present hundreds of tumor-associated antigens to immune system so that it can identify and wipe out cancer cells and trigger immune memory while sparing normal cells https://x.com/ScienceMagazine/status/1838662459151786088 A new generation of cancer-preventing vaccines could wipe out tumors before they form. Learn more on #WorldCancerResearchDay: https://t.co/505pC4yaf6 @NewsfromScience https://t.co/6BE5ZkgkW9 https://x.com/ScienceMagazine/status/1838662459151786088 A new generation of cancer-preventing vaccines could wipe out" [X Link](https://x.com/d_stock07734/status/1838671525483835541) 2024-09-24T20:07Z [---] followers, [----] engagements "Thanks Peter Great post Take a look at the outcome measures. We can only find another trial on the whole website that adopts measures like these. It is the combo trial. Only the treatment that can activate massive and sustainable t-cell infiltration into tumor sites can be qualified for measures like these. One specific part I want to point out is the measure of gamma-infereon increase. Recall what was mentioned in the poly-iclc paper published on Nature Communications. The increase of this specific biomarker correlates with significant OS. It seems like the measure of this specific biomarker" [X Link](https://x.com/d_stock07734/status/1840381553097990190) 2024-09-29T13:22Z [---] followers, [----] engagements Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing
@d_stock07734 d_stock
d_stock posts on X about $nwbo, acquisition, $mrk, has been the most. They currently have [---] followers and [----] posts still getting attention that total [---] engagements in the last [--] hours.
Engagements: [---] #
- [--] Week [------] -45%
- [--] Month [-------] +43%
- [--] Months [-------] +59%
- [--] Year [-------] +125%
Mentions: [--] #
- [--] Month [--] -67%
- [--] Months [---] +62%
- [--] Year [---] +186%
Followers: [---] #
- [--] Week [---] +0.31%
- [--] Month [---] +3.80%
- [--] Months [---] +4.70%
- [--] Year [---] +28%
CreatorRank: [---------] #
Social Influence
Social category influence stocks finance currencies technology brands countries cryptocurrencies travel destinations exchanges celebrities automotive brands
Social topic influence $nwbo #9, acquisition, $mrk #20, has been, $8750t, dc #1862, investment, in the, combo, solid
Top accounts mentioned or mentioned by @andrewcaravello @metacollectiveg @mdendream @dcvaxdaw @maveric92283613 @flemmingbruce @hoffmann6383 @alphavestcap @patrickwalsh14 @gonegoodguy @peterbrit @exosome @investor2013us @bunastarebio @pratapsinghmd @apwriter @bio99bio99 @smith348572 @michael48826289 @immortabio
Top assets mentioned Merck & Co., Inc. (MRK) AbbVie Inc (ABBV) Insmed, Inc. (INSM) Bristol-Myers Squibb Co (BMY) Amgen, Inc. (AMGN) Gilead Sciences, Inc. (GILD) ImmunityBio, Inc. Common Stock (IBRX) AstraZeneca PLC (AZN) Johnson & Johnson (JNJ) Alphabet Inc Class A (GOOGL) Sanofi (SNY) Regeneron Pharmaceuticals Inc (REGN) Novartis AG (NVS) Summit Therapeutics Inc. Common Stock (SMMT)
Top Social Posts
Top posts by engagements in the last [--] hours
"@sanderhamburger @ATLnsider @Anonymous275111 @RickHancock17 @metacollectiveG @Mionaer1 @sharpie510 @wpri12 Have you not read the slide from Dr. Bosch's presentation No other company can have such a marvelous achievement like NWBO. These molecules binding with peptides will activate CD4 t cells which play critical role in immune memory. Pretty soon patients receiving DCVax-L don't"
X Link 2023-07-31T20:34Z [---] followers, [----] engagements
"@3_Putt_Bogey_ @ATLnsider Each day the traffic on ihub is over 1.6m. That's why"
X Link 2023-08-31T16:38Z [---] followers, [--] engagements
"@andrewpannu Keytruda lacks of efficacy in treating cold tumors which account for about 80% of solid tumors. T- cell infiltration into cold tumor sites is essential for Keytruda to work"
X Link 2023-09-13T04:01Z [---] followers, [----] engagements
"@FormerPharmaGuy Try Fidelity. It has no fees"
X Link 2023-09-14T20:34Z [---] followers, [--] engagements
"@Cheesehammer11 Will the main media report the results from the manuscript before the review is done and the paper is officially published"
X Link 2023-09-15T21:12Z [---] followers, [---] engagements
"@metacollectiveG Just three shots within [--] days no chemo no radiation no terrible side-effects and patients can live over nine years. It is beyond miracle"
X Link 2023-09-15T23:52Z [---] followers, [----] engagements
"@TommyBaxendale AI Musella along with Fabio Iwamoto are on the team of Xcures mentioned in the new moonshot announcement. Take a look the board directors and partners"
X Link 2023-09-17T21:29Z [---] followers, [---] engagements
"@MonsonVO @KryptyPop @BiopharmIQ The reason is simple. $NWBO will make obsolete the treatment technology from all the companies in his portfolio"
X Link 2023-09-18T03:16Z [---] followers, [----] engagements
"@FormerPharmaGuy Keytruda accounts for about one-half of the Merck's revenue. Do you know what happened to Abbvie after the patent expiration of its Humira"
X Link 2023-09-18T15:09Z [---] followers, [--] engagements
"@flaskworks @MonsonVO @KryptyPop @BiopharmIQ I don't think that's the reason that media doesn't report DCVax-L. The reason is NWBO will pose a great threat to many companies in oncology business which put a lot ads on those media"
X Link 2023-09-18T16:35Z [---] followers, [---] engagements
"@jman4956 @BIO99_BIO99 Before the JAMA paper was published FDA had new guidance on ECA. Before NWBO submits application for approval FDA issued new guidance on RWD/RWE. It doesn't look like a coincident"
X Link 2023-09-19T03:07Z [---] followers, [---] engagements
"@Investor2013Us @jman4956 @BIO99_BIO99 It can also be used for the approval of DCVAX-L with poly-iclc. I strongly believe the UK special problem is using this combo"
X Link 2023-09-19T04:21Z [---] followers, [--] engagements
"@hoffmann6383 @TommyBaxendale Great point I never thought about this way. Now I think it is highly possible. If this combination gets approval then massive trials can be carried out in the next stage and approval can be granted using RWD"
X Link 2023-09-19T12:14Z [---] followers, [---] engagements
"@TommyBaxendale @hoffmann6383 You are right. I believe the paper came from UPenn and Dr. Liau is a coauthor. As a matter of fact with machine learning and AI stuff they can detect pseudopgression. I read some papers on this subject"
X Link 2023-09-19T14:59Z [---] followers, [--] engagements
"@xLUCCIOx Does Netflix have the series Star Trek Star Trek never ends. LoL"
X Link 2023-09-22T22:05Z [---] followers, [--] engagements
"@fireman02360 @CCCdet27 @FormerPharmaGuy @ItsMikePoarch It is harder and harder to have disruptive technology and science. NW has no competitors in the foreseeable future"
X Link 2023-09-28T18:09Z [---] followers, [--] engagements
"@fireman02360 @FormerPharmaGuy @CCCdet27 @ItsMikePoarch I don't recall saying that decisions are solely based on those two things. Decision are based on tons of reading of relevant journal papers. In reasonable near term $100 is still under value. As a matter of fact selling the majority under $100 is naive"
X Link 2023-09-28T20:48Z [---] followers, [--] engagements
"@maveric92283613 @patrickwalsh14 @GoneGoodguy Treatments for brain cancer was specifically mentioned in the NCI [----] budget. Feel like the pilot projects are related to the current combo trial"
X Link 2023-09-29T01:38Z [---] followers, [---] engagements
"@noMidwestHedgie @metacollectiveG You obviously haven't read about the currently ongoing combo trial initated two years ago. Had you read it carefully you would have bailed long time ago. You see all the measures You haven't seen anything like this while you have been kicking grandma shins"
X Link 2023-09-30T18:34Z [---] followers, [---] engagements
"@JayLourenco @metacollectiveG The man listed many times in his tweets the possible collaborators. Did you try to do your own DD to see if the list makes sense Collaborators: $MRK $REGN $BMY $JNJ $GILD $AMGN $RHHBY $AZN"
X Link 2023-10-02T18:54Z [---] followers, [---] engagements
"@MariaG816 @dcvax4life @metacollectiveG @StylianosIkono1 They know checkmate is coming. If they read the Nature preprint they probably knew why LP went to loan shark to get the loan: To lock them deep in the trap"
X Link 2023-10-03T02:15Z [---] followers, [---] engagements
"@maveric92283613 On the other side Merck has been preparing the platform for new types of RWD based clinical trials"
X Link 2023-10-03T21:52Z [---] followers, [--] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd You don't think the partnership has been forged quite a while ago"
X Link 2023-10-06T01:45Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd I always doubt about buyout. Correct me if I am wrong. For buyout to be feasible should buyer and seller have a rough idea about the potential value that DCVax-L can bring Take Prometheus as example two rare diseases Merck had pretty good idea about its current market cap"
X Link 2023-10-06T14:24Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd In the past [--] years the total number of unique peptides found is [----] through APOLLO Network. DCVax alone can tremendously expand the current database which will bring unfathomable value. You tell me how buyout is possible"
X Link 2023-10-06T14:39Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd IMO $NWBO will have partnership with both the public sectors and the private sectors. $MRK is just one of them. The solid tumor market is big enough for every big BP to have a slice of pie"
X Link 2023-10-06T14:41Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd IMO disruptive technology faces much less competition. With the IP NWBO owns other BPs can combine NWBO's base formula with their own products and compete against each other so that patients get the maximum benefit. Merge/Buyout is not a good option"
X Link 2023-10-06T16:35Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd BTW BPs have been awaken. Five hundred clinical trials on dendritic cells were registered on Have we seen any breakthrough other than DCVax-L"
X Link 2023-10-06T16:38Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd That's not a good illustration. Dendritic cell was found in 1970s. Dr. Steimann elicited anti-tumor response from dendritic cell in 1990s. After thirty years finally we have a dendritic cell vaccine"
X Link 2023-10-06T18:00Z [---] followers, [---] engagements
"@Investor2013Us @bunastarebio @pratapsinghmd Check out maverick_1's tweets in which he repeatedly mentioned several BPs as potential collaborators. Again no buyout or merge. I think we have spent enough time on this topic"
X Link 2023-10-06T18:01Z [---] followers, [--] engagements
"@Investor2013Us @JdBell20 @bunastarebio @pratapsinghmd Again no merge no buyout. No BP cannot afford it. If you seriously check if BPs are building cell manufacturing facility in the past two years and have job openings related to proteomic analysis you will know there is no buy out and no merger"
X Link 2023-10-07T23:48Z [---] followers, [--] engagements
"@exosome @Thislifetime22 @malukDcabob @bioboybull @AminoProtein Here are some slides from Dr. Bosch's present. He mentioned from a single sample over thirty seven thousand peptides were found. My question: will NWBO be able to file patents for all the new peptides found by DCVax-L from all solid tumors"
X Link 2023-10-08T23:21Z [---] followers, [----] engagements
"@FormerPharmaGuy @fornybarbio Why are you frustrated You just have a tiny position. If it takes one extra month to get everything correct it is totally worth it. In one month you may realize who is really amateurish"
X Link 2023-10-14T03:12Z [---] followers, [---] engagements
"@maveric92283613 then those collaborators need to hire high-caliber professionals to do proteomic analysis. ELISA is the one mentioned a lot in Dr. Liau's papers which is related to proteomic analysis"
X Link 2023-10-15T16:55Z [--] followers, [--] engagements
"@maveric92283613 Take a look at $JNJ first. Here is one job opening: Senior Scientist Proteomics Even though $JNJ has one approval of car-t therapy the job description still makes me wonder if it has anything to do with possible collaboration with NWBO"
X Link 2023-10-15T17:12Z [---] followers, [---] engagements
"@maveric92283613 The interesting thing is that similar job openings for other BPs. Take Roche for instance"
X Link 2023-10-15T17:14Z [---] followers, [--] engagements
"@metacollectiveG NWBO already made some info. explicit. The company said it has 1.7m pages of documentation foe filing and it will require MAA 150-day assement timeline. How's it possible to finish the review for a totally brand new therpay within [---] days Reviewing totally new therapy should"
X Link 2023-10-16T00:07Z [---] followers, [---] engagements
"@metacollectiveG take much longer time since the reviewers are not familiar. It is obvious the only possibility is rolling review. Sorry for the weak hands on Friday who cannot read the context between the lines"
X Link 2023-10-16T00:11Z [---] followers, [---] engagements
"@BIO99_BIO99 What could bring this level of confidence to the government White House deputy chief of staff Bruce Reed said in a statement. "At his direction the entire federal government is mobilizing like never before to end cancer as we know it.""
X Link 2023-10-17T16:28Z [---] followers, [----] engagements
"@Lewis_Tierney @albtur_mnymkrs The project was just renewed. But don't forget about $BMY which had a five-year collaboration with Robert Prins and Linda Liau"
X Link 2023-10-19T14:33Z [---] followers, [---] engagements
"@sanderhamburger @ABenS2060 @ATLnsider At this stage plx-3397 cannot be explicitly mentioned. As a matter of fact this is the part that all the concerning parties are trying to hide. You simply cannot get it"
X Link 2023-10-21T18:00Z [--] followers, [--] engagements
"@WayneLee1983 @metacollectiveG @JackNdreu I don't think it matters when it will be published. What it matters is that the preprint sends a clear message on the prospective trials in which biomarker analysis plays a key role in evaluating the outcome of the trials. Note that the current combo trial was mentioned"
X Link 2023-10-29T18:04Z [---] followers, [--] engagements
"@KeoghBernard @peter_brit I doubt about buyout. I give you just one reason. In Dr. Bosch's presentation we can see from one example that tens of thousands of peptides can be extracted. I was always wondering if NWBO could file patents for all the newly found tumor specific peptides from solid tumors"
X Link 2023-11-03T14:56Z [---] followers, [---] engagements
"@exosome Likewise for CSF1R-I (PLX3397). Merck and Daichii had a collaboration trial using PLX3397 combined with Keytruda. The trial was terminated because of lack of efficacy. But once it is combined with DCVax-L we can see amazing efficacy in animal models"
X Link 2023-11-05T19:01Z [---] followers, [---] engagements
"@exosome If you take a look at the clinical trial of DCVax-L with poly-iclc the objective was to find the most effective combination ingredient for DCVax-L and the number of enrollment was [--] patients. But with [--] patients [--] on poly-iclc [--] on resiquimod [--] on"
X Link 2023-11-05T19:05Z [---] followers, [---] engagements
"@HenryMuney @biggercapital @joanlappin @ATLnsider @rago_carlo @wkovash @GeneralVentures Humira brought Abbvie $2000 over [--] years. But the 1st month biosimilar hits the market revenue from Humira down by 26%. Both Keytruda and Opdivo will expire in [--] yrs and there is no difference in efficacy. They need DCVax-L"
X Link 2023-11-13T15:10Z [---] followers, [---] engagements
"@TheeBeardedG @maveric92283613 @RichFairgrieve @rsloftx @elonmusk What does it mean "Phase II trials planned" Do we have PR on this"
X Link 2023-11-20T21:35Z [---] followers, [---] engagements
"@sharpie510 I just love these figures and have to post them again. For CIs to work you have to have plenty t cells in tumor micro-environment. But 80% of solid tumors have t cell depleted micro-enironment. That's why CIs lack of efficacy for cold tumors. For p3 trial patients after SOC"
X Link 2023-11-21T01:44Z [---] followers, [---] engagements
"@dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @MDendream @rickcav @apwriter @Lewis_Tierney If you google it you will see many researcher were trying to use the same protocl on other targets and failed. Dr. Reardon who just wrote the hitting piece failed in trying to combine peptide vaccine with poly-iclc and imiquimod (similar to resiquimod)"
X Link 2023-11-26T04:50Z [---] followers, [---] engagements
"@dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @MDendream @rickcav @apwriter @Lewis_Tierney Carolyn Britten currently Vice President Early Development Oncology at Amgen who used to work at Jonsson Comprehensive Cancer Center at UCLA tried DC vaccines with the same combination on pancreatic cancer at Medical University of South Carolina and failed"
X Link 2023-11-26T04:56Z [---] followers, [---] engagements
"@MDendream @dcvaxdaw @patrickwalsh14 @metacollectiveG @woodman267 @rickcav @apwriter @Lewis_Tierney Well since I am new I don't care about GTM strategy/execution or impact on market value. I only care how revolutionary and disruptive the technology is. As a matter of fact in the case of NWBO too much experience could prevent someone from being bold and aggressive"
X Link 2023-11-26T05:25Z [---] followers, [---] engagements
"@metacollectiveG @MDendream @dcvaxdaw @patrickwalsh14 @woodman267 @rickcav @apwriter @Lewis_Tierney I agree. For those who complain about crawling speed I wonder if they know how big is the empire LP and LG are trying to build. My gut tells me the size of the empire will be well beyond my imagination"
X Link 2023-11-26T05:44Z [---] followers, [---] engagements
"@MDendream @metacollectiveG @dcvaxdaw @patrickwalsh14 @woodman267 @rickcav @apwriter @Lewis_Tierney What did those people in Detroit say when Elon Musk decided to manufacture EV What did the people in Boeing think about Elon Musk when he tried to design recycle rockets I know it is different field. But comparison can be made"
X Link 2023-11-26T15:07Z [---] followers, [--] engagements
"@BIO99_BIO99 Not a good news for Regeneron which has big bet on chimeric antigen receptor (CAR) T-cell therapy. But it surely makes us love DCVax-L even more. Has DCVax-L bring to immune system anything artificially made Did NWBO use synthetic this or that or engineering this or that None"
X Link 2023-11-28T19:39Z [---] followers, [----] engagements
"@augie_percoco @peter_brit No doubt there was an ulterior motive. Just scroll down the webpage and you will see why they wrote the hitting piece"
X Link 2023-11-30T06:07Z [---] followers, [---] engagements
"@augie_percoco @peter_brit Dr. Reardon currently is the PI of the clinical trial sponsored by Immunomic Therapeutics. He is also on the Advisory Board of the company. Did you see he disclosed this information in the paper"
X Link 2023-11-30T06:16Z [---] followers, [----] engagements
"@BIO99_BIO99 @InvestorZlu Zlu Recall when bio99 wrote the Reddit post you were concerned about that the SOC in p3 trial could be detrimental to patients in a way it could suppress immune response. I was trying to see if there are any other clinical trials that used Expansion of T cell"
X Link 2023-12-09T18:59Z [---] followers, [--] engagements
"@InvestorZlu @BIO99_BIO99 Seems to me NWBO does not want to get big attention for now"
X Link 2023-12-10T14:50Z [---] followers, [---] engagements
"@apwriter Oh yeah The hiring frenzy has been going on for a while. Use the keywords to Google it merck + west point + jobs Sign up for the job alerts and monitor the job postings. You will be amazed"
X Link 2023-12-10T15:35Z [---] followers, [---] engagements
"@exosome Dr. Ichim did you by any chance read the interview of Dr. Monica Bertagnolli by NPR It seems like she was very excited about using immunotherapy to treat cancer"
X Link 2023-12-14T05:21Z [---] followers, [---] engagements
"@dcvaxdaw @metacollectiveG @StockSlanginSam @LisainNJUSA @FlemmingBruce @GREEK__G0D @escctrl74 @alphavestcap I thought they were fools. It turns out they are hyenas. How is it possible to reason things out with hyenas"
X Link 2023-12-18T07:15Z [---] followers, [---] engagements
"@metacollectiveG Humira for an array of inflammatory diseases brought AbbVie $200b in [--] years. Cannot imagine how much DCVax-L which can treat and potentially cure all solid tumors will bring to NWBO. Must be a big multiplier of $200b"
X Link 2023-12-21T19:37Z [---] followers, [---] engagements
"@dcvaxdaw @jamestheright1 @Siddco1 How about revolutionary science in biotech"
X Link 2023-12-22T17:23Z [---] followers, [--] engagements
"@jamestheright1 @dcvaxdaw @Siddco1 So you do agree there are liars among them"
X Link 2023-12-23T15:26Z [---] followers, [--] engagements
"@hoffmann6383 Here is the transcript"
X Link 2024-01-09T22:10Z [---] followers, [---] engagements
"@hoffmann6383 While some Merck & Co. investors may still get the heebie-jeebies when thinking about Keytrudas patent cliff in [----] but the companys CEO Rob Davis now thinks its just another year. Just another year Sounds so confident. He must have known"
X Link 2024-01-11T17:50Z [---] followers, [---] engagements
"@hoffmann6383 what happened to Abbvie when its blockbuster drug Humira hit the patent cliff. Does Merck currently have something under development that will help Merck surpass the patent cliff I think we will know the answer soon"
X Link 2024-01-11T17:55Z [---] followers, [--] engagements
"@dcvaxdaw @ImmortaBio @andrewcaravello DM I cannot see BO. BO is not good for the benefit of patients. I read Dr. Liau's paper in which she talked about overexpression of pd-L1 from cancer cells. You see those BPs which have PD-L1 inhibitors can combine their products with DCVax-L. Let BPs compete with each other"
X Link 2024-01-11T18:27Z [---] followers, [---] engagements
"@dcvaxdaw @ImmortaBio @andrewcaravello I suspect there must be a good reason that it took a long time to publish the JAMA paper. Here the top [--] pharma companies by [----] revenue. If you check how many clinical trials on DCs they have sponsored I am sure you would be amazed"
X Link 2024-01-12T02:55Z [---] followers, [---] engagements
"@dcvaxdaw @ImmortaBio @andrewcaravello Amgen: [--] Roche: [--] BMY: [--] Pfizer: [--] Sanofi: [--] Merck: [--] AbbVie: [--] GSK: [--] J&J: [--] Novartis: [--] (Asthma) AstraZeneca: [--] Takeda: [--] Eli Lilly: [--] Gilead: [--] Bayer: [--] (Multiple Sclerosis) Boehringer Ingelheim: [--] Novo Nordisk: [--] Moderna: [--] Merck KGaA: [--] BioNTech: 0"
X Link 2024-01-12T03:12Z [--] followers, [--] engagements
"@maveric92283613 @dcvaxdaw @ImmortaBio @andrewcaravello We can see clearly that those BPs don't have the infrastructure for the type of cell therapy that NWBO developed. If BPs want to partner with NWBO they have to hire new people and build new facilities"
X Link 2024-01-12T16:45Z [---] followers, [---] engagements
"@maveric92283613 @dcvaxdaw @ImmortaBio @andrewcaravello A job from Merck "The group is responsible for establishing the science engineering and knowledge required for today's innovative and accelerated commercialization of novel Vaccines Biologics and pharmaceutical products and combination products.""
X Link 2024-01-13T05:09Z [---] followers, [---] engagements
"@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello Thanks Mav. Here is the invaluable list. Collaborators:$MRK $AMGN$REGN$BMY$JNJ $GILD$RHHBY$AZN Take $GILD as an example. For a company willing to pay up to $658.5m to have a license from a company which only has preclinical data on dendritic cells to treat RA"
X Link 2024-01-13T23:41Z [---] followers, [---] engagements
"@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello it is certain that $GILD would love to pay many times of $600m to get license from NWBO to treat many tough virus. We can see in the combo trial patients with HIV hepatitis B & C TB positive are excluded in the trial. What if in the compassionate use"
X Link 2024-01-13T23:53Z [---] followers, [---] engagements
"@maveric92283613 @ImmortaBio @dcvaxdaw @andrewcaravello patients with these viruses or bacteria can be included and the viruses or bacteria were eliminated Given the fact that $GILD once spent one third of its market cap to buy the cure drug for hepatitis C I have no doubt $GILD would like to spend big money on DCVax-L"
X Link 2024-01-13T23:58Z [---] followers, [---] engagements
"@maveric92283613 @sharpie510 This reminds me that most likely it is Merck which forced AI to take down Dr. Liau's webinar video twice. Now I suspect LP can name the rules for house of cards and BPs have to following the rules"
X Link 2024-01-14T00:35Z [---] followers, [---] engagements
"@maveric92283613 @sharpie510 Here is the combo trial between BMY and NWBO which was supposed to start in January [----]. But in [----] the PI of the trial had meetings with both BMY and Merck according to Seems to methis two BPs fought for the trial"
X Link 2024-01-14T00:43Z [---] followers, [---] engagements
"@metacollectiveG @compozee_ @fireman02360 @dcvaxdaw @LisainNJUSA @mittypost I hope the approval comes from all RAs. Merck's vaccine manufacturing facility is going to operate 24/7 early this year. What if it has something to do with DCVax-L Then DCVax-L must be approved by FDA before Merck can manufacture it. https://careers.utpb.edu/jobs/merck-co-inc-west-point-quality-line-oversight-program-2024/ https://careers.utpb.edu/jobs/merck-co-inc-west-point-quality-line-oversight-program-2024/"
X Link 2024-01-16T15:03Z [---] followers, [---] engagements
"@smith348572 @MDendream @metacollectiveG @dcvaxdaw @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 So $NWBO has to file for approval with different RAs separately It doesn't make sense. How did you come up with the number $20"
X Link 2024-01-18T02:11Z [---] followers, [---] engagements
"@MDendream @dcvaxdaw @Mtnjack68 @metacollectiveG @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 Think whatever you like. If you have no conviction and lose confidence in the management don't torture yourself. Find a traditional company that fits your mindset"
X Link 2024-01-18T13:55Z [--] followers, [---] engagements
"@MDendream @dcvaxdaw @Mtnjack68 @metacollectiveG @brogan_marcus @LisainNJUSA @JackNdreu @mittypost @ThomasOwenMcCa1 Are you conjuring up something You almost strike me as a replica of flipper on ihub"
X Link 2024-01-18T20:01Z [---] followers, [---] engagements
"@MDendream @mattkolleck1 @metacollectiveG the amazing t cell increase and expansion resulting from the treatment. But did BPs like an amazing treatment like DCVax-L back then Absolutely no. DCVax-L didn't fit their business model. Note that Merck is the manufacturer of TMZ"
X Link 2024-01-19T20:46Z [---] followers, [---] engagements
"@MDendream @mattkolleck1 @metacollectiveG IMO the main reason Merck and others are interested in DCVax-L is that they are out of option. They see how traumatic it can be as illustrated by the patent expiration of Abbvie's humira if they hit the patent wall"
X Link 2024-01-19T20:49Z [---] followers, [---] engagements
"@Jordongf2 @Mionaer1 It is definitive that the approval is incoming. In the ASCO present of last June [---] patients received DCVax-L. In August Les said about [---] patients were treated. Two hundred more patients in less than [--] months. MHRA knows well about the urgency of the approval"
X Link 2024-01-20T17:26Z [---] followers, [---] engagements
"@Jordongf2 @Mionaer1 Has anyone wondered about what types of combinations could be used in the UK Specials program The case #1 strikes me as DCVax-L + Poly-ICLC. But it was [--] yrs ago. As shown in the document doctors in UK has the discretion to decide the combinations"
X Link 2024-01-20T17:37Z [---] followers, [--] engagements
"@metacollectiveG @FlemmingBruce Agree with you totally. I just love this present from Dr. Liau so much. Anytime I have chance I want to repeat it. These green dots are the immunosuppressive macrophages and plx3397 can prevent monocytes from differentiating into macrophages"
X Link 2024-01-22T03:55Z [---] followers, [----] engagements
"@metacollectiveG @FlemmingBruce It strikes me that Dr. Liau already found the roadmap for the cure. All it matters now is to have massive manufacturing facilities ready. I thought as we were approaching the finish line the longs would have more confidence in NWBO. It turns out I was wrong"
X Link 2024-01-22T03:58Z [---] followers, [---] engagements
"@exosome @SphereThera Dr. since the paper mentioned about murine model I did some google search and I was amazed by the fact that "dogs and people share over [-----] special genes called orthologs". No wonder Merck and NCI partner with Vetigenics"
X Link 2024-01-26T06:44Z [---] followers, [---] engagements
"@SphereThera @exosome Have you by any chance read about this company which is trying to develop a technology to dampen immune response It has something to do with dendritic cell too. Amgen and Gilead fronted big money which from one perspetive reflects how valuable NWBO is"
X Link 2024-01-26T07:03Z [---] followers, [---] engagements
"Upstream Senior Scientist - Continuous & Expression Technologies "Develop innovative and disruptive technologies for next-generation large molecule biologic/vaccine manufacturing processes.""
X Link 2024-02-01T02:07Z [---] followers, [---] engagements
"Keytruda biosimilar Opdivo biosimilar"
X Link 2024-02-02T21:11Z [---] followers, [---] engagements
"@MDendream @dcvaxdaw So discover is a good word that should be encouraging for NWBO shareholders. It means Merck is being serious"
X Link 2024-02-03T21:35Z [---] followers, [----] engagements
"@ThomasOwenMcCa1 @metacollectiveG @jhod @MDendream @dcvaxdaw @GoneGoodguy @US_FDA Community Oncology Setting The term sounds familiar. DCVax-L is perfect for community setting"
X Link 2024-02-04T06:29Z [---] followers, [----] engagements
"Most importantly the Moonshot program was reinvigorated. Given the extraordinary efficacy of DCVax-L I don't see why DCVax-L cannot play a role in the program. Here is the part taken from the news. It strikes me the Federal Government really have the sense of urgency to get the job done. "Joe Biden is determined to be a president for all Americans. That is why his Unity Agenda is about making progress on the biggest challenges we all face regardless of party" White House deputy chief of staff Bruce Reed added in a statement. "At his direction the entire federal government is mobilizing like"
X Link 2024-02-04T06:38Z [---] followers, [---] engagements
"No one knows. As a matter of fact investors don't need to know. All we need to know is how amazing the science is. We can see clearly revolution in bioscience doesn't come often. Abbvie didn't a better alternative to Humira after making $200b in the last [--] years. Neither Merck nor BMY found one to their CIs. All they can do is to make a small change to extend their patents. We can see from the JAMA paper it took on average [--] months to have pseudo-progression resulting from massive t-cell infiltration into tumor sites and there are only three cases intracranial edema caused by"
X Link 2024-02-05T15:09Z [---] followers, [---] engagements
"What do you mean we are approaching a binary event Several binary events have already happened. I am surprised you are not aware any of them. No wonder your tone is full of negativity. I did go through your post at ihub. I specifically focused on what's your take on ASCO presentation since you always claim you believe in science. I saw nothing there"
X Link 2024-02-06T04:27Z [---] followers, [---] engagements
"Is it possible that each BP can get DCVax-L through franchise and does its own R&D by either combining their own product with DCVax-L or using their expertise in a specific field to explore the full potential of DCVax-L. AZN can combine its PDL-1 inhibitor with DCVax-L. Gilead can do R&D on the application of DCVax-L in antiviral field. Abbvie can use it for autoimmune diseases"
X Link 2024-02-07T17:03Z [---] followers, [--] engagements
"Do you have common sense about science Have I mentioned to you that Abbvie didn't find any alternative to humira Neither Merck nor BMY found any good ones to their CIs. So they have to make minor changes to bypass the patent cliff. You think revolution in biotech can come easily as long as BPs start working on it. You are totally wrong. Here is what Dr. Ralph Steinman wanted for anti-tumor response. I wanted as much to initiate a cancer immune response as I wanted to initiate one against infection. There are over [---] clinical trials on dendritic cells. Only DCVax-L can make Steinman's dream a"
X Link 2024-02-08T04:04Z [---] followers, [---] engagements
"Here is the figure from Dr. Liau's present. Pink color means t cells which are trying to kill cancer cells (blue color). Those green dots are tumor-associated macrophages. Daichii is the only company which has FDA approved small molecule oral CSF1R inhibitor which can prevent monocytes from differentiating into macrophages. Merck terminated collaboration with Seagen after spending $1.6b on the ADC trials. As for the reason "LV has been shown to be clinically active with a tolerable safety profile however the emerging treatment landscape with newer therapeutics introduces a higher efficacy"
X Link 2024-02-08T19:05Z [---] followers, [--] engagements
"I assume everyone knows the story about Keytruda which was not invented by Merck. It was invented by three scientists from the Netherlands. When Merck bought keytruda the research group even had problem getting the funding for further research and Merck put it on shelf. It was because BMY made breakthrough in Opdivo that made Merck jump start keytruda program. If BPs want to step into the empire of dendritic cell vaccine they will find all the possible route has been blocked by the patent wall which LP has been trying to build over many years. One can simply check how many dendritic cell"
X Link 2024-02-09T04:51Z [---] followers, [---] engagements
"The correlation between AZN and NWBO is possible and reasonable. @maveric92283613 has mentioned a list of BPs that could strike partnership with NWBO since last year. AZN is one of them. If anyone still has doubt open the following file and search for "AstraZeneca" Or one can simply take a look to see who has close collaboration with the scientists from AstraZeneca. #DISRUPTOR #CANCER $NWBO Collabs: $MRK $AMGN $REGN $BMY $JNJ $GILD $RHHBY $AZN From [--] yr holder Beachhyena (SoCAL) https://t.co/mjd9nr1TK1 AND see reply by [--] yr Doc_Logic: Full agreement $NWBO [--] GEN Wealth: Rockets need FUEL"
X Link 2024-02-15T20:28Z [---] followers, [----] engagements
"Here is an abstract from Dr. Liau in which she mentioned about using the technologies to gain a better understanding of the immune cells. Take some of the keywords to see if Merck is trying to recruit people with backgrounds on these technologies. Immunofluorescence [----] University Recruiting - Cambridge Neuroimmunology Cell Biology Co-Op Candidates must have cell staining methods including Immunofluorescence and cell masks or cell structural staining methods Director Global Oncology Precision Medicine - Strategy & Operations The position also requires solid comprehension of business case"
X Link 2024-02-16T16:02Z [---] followers, [---] engagements
"Did you realize how toxic the treatment is Patients have to go through intensive chemo so that their immune system can be knocked down before the TIL infusion. Then high-dose interleukin- [--] has to be administered to promote t cell activation. This gave me even more confidence that without doubt FDA is going to approve DCVax-L which has amazing efficacy and nontoxic"
X Link 2024-02-18T18:26Z [---] followers, [--] engagements
"I don't see how the market is behaving itself. For MMs fail-to-deliver means they didn't borrow the real shares after [--] working days and their naked shorts become fails-to-deliver. Market makers have special exemptions from the rules: they are allowed to carry a naked short for up to twenty-one trading days before they have to borrow a share. When the share is not borrowed in the allotted time and a buy-in does not occur and they rarely do the naked short becomes a fail-to-deliver (of the borrowed share)"
X Link 2024-02-19T17:59Z [---] followers, [---] engagements
"It is interesting that Amgen is also trying to hire people with biomarker expertise. Scientist- Clinical Biomarker Assay Development Scientist Biomarker Discovery Scientific Associate Director Translational Pathology"
X Link 2024-02-22T03:58Z [---] followers, [---] engagements
"There will be no BO. All BPs currently have their own approved drugs for cancer. Once DCVax-L (DCVax-L + Poly-ICLC) gets approval BPs can get franchise from NWBO combine DCVax-L with their own drugs run observation study trials just like the platform study currently running in UK and then file for regulatory approval based RWE/RWD. Seems to me it is that simple"
X Link 2024-02-23T13:42Z [---] followers, [---] engagements
"@dcvaxdaw @RichFairgrieve That I don't know. I am only concerned about if the trial results are amazing and whether the combination of DCVax-L + Poly-ICLC + Keytruda was adopted. Given the fact that since [----] the UMC Mainz started core research on dendritic cells I would say yes to both possibilities"
X Link 2024-02-23T23:06Z [---] followers, [--] engagements
"I have no doubt. Here is the figure from Dr. Liau's presentation which corresponds to the arm in which pd1-inhibitor was given first. In this figure red dots are activated t cells that infiltrated into tumor sites and green dots are macrophages. I asked ChatGpt to count me how many red dots are in the figure. The number is [---] Note that this is a 2d figure and the area must have been magnified a lot for observation purpose. But there are still [---] t cells The base-line for normal person varies between [--] and [--]. Plx3397 will prevent monocytes from differentiating into macrophages which means"
X Link 2024-02-29T19:38Z [---] followers, [---] engagements
"The start of hiring frenzy from AZN at Gaithersburg Maryland. Senior Global Study Manager Cell Therapy Oncology R&D Early Clinical Executive Director Head of Virology and Vaccine Research Early V&I Associate Scientist - Bioscience Immunology Senior Scientist Translational Proteomics Global Mass Spectrometry Senior Scientist In Vivo Pharmacology Cell Therapy Associate Director Analytical Cell Therapy Global MS&T Senior Director Oncology Safety Science & Discovery Associate Director Study Leader Cell Therapy Senior Scientist Immuno-Oncology Matan Companies Signs [------] SF Full-Building Lease"
X Link 2024-03-02T02:52Z [---] followers, [----] engagements
"The case study may be about Owain James. The tumor is 14cm only half of it can be removed and three vaccines were made. But with the intense anti-tumor response the remaining half shrank into cyst under continual pounding of the immune system. I suspect that in his case the combination of DCVax-L + poly-iclc + keytruda was adopted"
X Link 2024-03-05T23:19Z [---] followers, [----] engagements
"From the following webpage we can have an idea about the meaning of the nutritional support for the immune system. He is on a host of supplements IV treatments regular hyperbaric oxygen therapy & I am even injecting him [--] times a week with mistletoe therapy. Everything is going well just wanted to provided a quick update; Owain has had [--] DC Vaccines were now doing everything to increase his immune response including Intravenous Vit C Helleborous Artemisinin and an injection of Mistletoe therapy 3x per week. We are working hard to educate ourselves on how to block all the cancer pathways with"
X Link 2024-03-06T01:23Z [---] followers, [--] engagements
"In some recent job postings from AstraZeneca cure for cancer was repeatedly mentioned. AstraZeneca's checking point inhibitor even cannot cure all the hot tumors. What could possibly make the company become so ambitious and optimistic that it can provide cures for cancer in every form "AstraZeneca is leading a revolution in cancer care with the ambition to provide cures for cancer in every form following the science to understand cancer and all its complexities to discover develop and deliver life-changing medicines to patients." Senior Director Global Oncology Policy & Advocacy (GI Cancers)"
X Link 2024-03-08T22:53Z [---] followers, [----] engagements
"@Cred54675419C Did Pfizer spend $43b acquiring Seagen If mRNA cancer vaccine were so effective I cannot see why Pfizer would spend this huge amount of money on ADC"
X Link 2024-03-09T22:26Z [---] followers, [--] engagements
"Here are all the cancer trials run by Moderna or Moderna with Merck or Moderna with AZN. One trial was terminated because of lack of efficacy. Another was cancelled. Simply by taking a look at the outcome measures in those trials and comparing them with the ones adopted in the combo trial we know for sure we are in a universe completely different from the mRNA one. Pay special attention to the following poster. Note CD4 t cells were not mentioned. The yellow dots are CD8 t cells. I cannot see too many yellow dots. I haven't found any other companies which can generate the plots on the number"
X Link 2024-03-09T23:34Z [---] followers, [---] engagements
"Our Continuous & Expression Technologies group is looking for creative and innovative scientists/engineers at multiple levels to innovate in upstream process intensification. Out team works closely with Vaccine Process Development partners on exciting new targets and platforms across multiple disease areas (e.g. Infectious Disease and Vaccines Neuroscience). Come join us on our mission to deliver high-quality vaccines to patients Associate Principal Scientist Upstream - Continuous & Expression Technologies Specifically CET is seeking a Principal Scientist specializing in perfusion cell"
X Link 2024-03-10T01:25Z [---] followers, [----] engagements
"Amazing picture. Note that this is for DCVax-L only. We haven't seen anything like the case of DCVax-L + poly-iclc or DCVax-L + poly-iclc + Checking point inhibitors. But after signing NDA CEOs and their expert teams can see a lot more amazing stuff. IMO the more color dots over base line the better the results are. In this regard simply take a look at the results that Professor I. Melero obtained from the trial on other solid tumors using his version of dendritic cell vaccine combined with poly-iclc we will have a sense what truly amazing results NWBO has delivered"
X Link 2024-03-11T16:20Z [---] followers, [----] engagements
"LP and her team conquered another Mount Everest in technology and filed the application package of 1.7m pages. Yet the net loss of [----] is less than that of [----]. Those who question LP's leadership can stop whining. The special difficulty involved in developing the Flaskworks machine was that unlike other cell types the dendritic cells tightly adhere to the surface of the culture vessel (similar to barnacles). Extracting them from inside the culture vessel without damaging the cells or reducing the yield of doses was extremely challenging. Other cells (including T cells) are generally"
X Link 2024-03-13T04:51Z [---] followers, [---] engagements
"These three patients were from the p3 trial. The t cell expansion was measured at 4th and 8th months. I suspect we can assume that these results were obtained at least nine years ago when the enrollment of the p3 trial was finished. There is much more that we haven't seen. Cannot wait to read the paper on the case study mentioned in 10-K"
X Link 2024-03-13T14:38Z [---] followers, [---] engagements
"@Nina_kd My wild thinking is that it's no hurt for any BP CEO to sign NDA and take a look at what LP has in the safe. But I don't anticipate LP would show the data on the collaboration trial between NWBO and Merck since Merck wouldn't agree"
X Link 2024-03-14T03:58Z [---] followers, [---] engagements
"True. It is interesting to see Mainz installed core facility for mass spectrometry & proteomics of the research center for immunotherapy in [----]. It is even more interesting to read the description of the core research. I heard before in biotech nothing is coincident. The research activities realized at the Institute of Immunology concern various aspects of the induction of innate and adaptive immune responses. As part of our investigations of the innate immune system we analyze the function and regulation of mast cells and neutrophils. Of special interest are the consequences of"
X Link 2024-03-17T05:33Z [---] followers, [---] engagements
"AZN bought Fusion for $2.4b. Fusion's therapy targets the most common tumor specific mutant called EFGRvIII. Dr. Liau Nature preprint analyzed the variation of over 19k genes before and after receiving DCVax-L + Poly-ICLC. EFGRvIII is just one of them. It is logic to conjecture that researchers can find other tumor specific mutants so that the therapy can have better precision in attacking cancer cells. https://fusionpharma.com/wp-content/uploads/2023/04/AACR-poster_EGFRvIII_2023_FINAL.pdf"
X Link 2024-03-21T02:13Z [---] followers, [----] engagements
"An interesting job from Merck West Point Campus. Scientist Continuous Manufacturing Technologies - Vaccine Process Development The Continuous & Expression Technologies Group (CET) within the Process Research & Development Enabling Technologies department is seeking motivated and creative individuals who are looking for an opportunity to positively impact our companys manufacturing platforms while actively supporting drug development in the biologics vaccine and small molecule spaces. Specifically CET is seeking Scientists specializing in bioprocessing technologies for vaccine candidates"
X Link 2024-03-22T18:47Z [---] followers, [---] engagements
"A very interesting job posting from AZN. My understanding about this job is to use proteomics analysis to find "novel target" for ADC. The target has to be tumor specific which only exists in cancer cells. Which company can provide AZN and other BPs with tumor specific targets The answer is obvious. Is it clear now why all the BPs are trying to acquire ADC companies like crazy "As a Data Scientist in Translational Proteomics you will provide computational support to enable critical proteomics data input for cancer biomarker development. You will support building ADC-target landscape to"
X Link 2024-03-22T21:05Z [---] followers, [----] engagements
"We can use Prometheus as an example. The market for UC and CD was $23b in [----]. Merck paid $11b in [----]. The solid tumor market in [----] is $209.6b from the internet. Now I suspect it should be $300b. The price tag should $150b at minimum since the market on antiviral and antibacterial fields and autoimmune diseases are not included and the potential loyalty from licensing neo-peptides found by the use of DCVax-L. Can any BP pay $150b The franchise is a clear signal that there is no BO"
X Link 2024-03-23T14:14Z [---] followers, [----] engagements
"$1b house No doubt jury will have this in their mind when they assess the punitive damages. I hope they also bring to their mind the fact that he spent $43m on the US Constitution. Ken Griffin billionaire CEO of hedge fund Citadel paid $43.2 million for a first-edition copy of the U.S. Constitution at a Sothebys auction. The U.S. Constitution is a sacred document that enshrines the rights of every American and all those who aspire to be Griffin said in a statement. That is why I intend to ensure that this copy of our Constitution will be available for all Americans and visitors to view and"
X Link 2024-03-24T04:22Z [---] followers, [---] engagements
"AZN is looking for Senior Scientist Oncology TTD Target Discovery Gaithersburg MD. It seems like the job is about finding the new targets for its ADCs. I suspect there is now an much better and efficient way in finding new targets. "This is your chance to join our Tumor Targeted Delivery team in Early Oncology in Gaithersburg MD USA. As a Senior Scientist you will lead target validation efforts for tumor-targeted therapies such as antibody-drug-conjugates (ADCs) and targeted radio-conjugates." "As a Senior Scientist you will act as target validation lead for one or more pipeline programs. You"
X Link 2024-03-24T20:46Z [---] followers, [---] engagements
"Merck Others Look to Immunotherapy Combos as Next Frontier in Oncology We are moving toward a future where we have enough medications that each work individually and have minimal side effects so that we can create even larger combinations which offer the most benefit to people said David Weinstock vice president of discovery oncology at Merck whose blockbuster immunotherapy Keytruda is a go-to for such combos. Keytruda's main function is to unmask t cells so that they can recognize cancer cells. It only works under the condition that t cells are around cancer cells. If there are no t cells"
X Link 2024-03-25T16:03Z [---] followers, [----] engagements
"Interesting answers from ChatGPT on how dendritic cells can help in identifying tumor specific targets for ADCs. Here's how dendritic cells can contribute to identifying tumor-specific targets for ADCs: Antigen Presentation: Dendritic cells capture antigens including those from tumor cells through various mechanisms such as phagocytosis receptor-mediated endocytosis or cross-presentation. Tumor-specific antigens presented by dendritic cells can potentially be targeted by ADCs. Screening Assays: Researchers can utilize dendritic cells in screening assays to identify antigens that are"
X Link 2024-03-27T19:14Z [---] followers, [----] engagements
"Size exclusion chromatography (SEC) is the analytical gold standard for the separation and accurate quantitation of aggregates monomers and lower molecular weight fragments contained in biotherapeutic peptides and proteins including monoclonal antibody (mAbs) drugs. Did Dr. Liau use SEC in her research Sure did. "For enzyme assays using recombinant IDH1 enzyme proteins were purified from E coli using Ni affinity and size-exclusion chromatography." The interesting part is that all these BPs are recruiting people with skills on SEC. Merck Principal Scientist Biologics Analytical Research &"
X Link 2024-03-30T03:52Z [---] followers, [----] engagements
"@BIO99_BIO99 @sharpie510 Abbvie may have read the paper by now. On the webpage which was set up on January [--] [----] according to Wayback Machine the word "cure" is everywhere. https://www.abbvie.com/science/the-case-for-big-bets.html https://www.abbvie.com/science/the-case-for-big-bets.html"
X Link 2024-03-30T17:32Z [---] followers, [---] engagements
"If we believe we are embracing something revolutionary we have to dream big. They are trying to build another Silicon Valley in immunology. The acquisition of HCA hospital approved by the University of California Board of Regents was done. There are going to be a lot of clinical trials. Is the University of California Board of Regents also the owner of some of the DCVax-L patents UCLAs goal is to build the immunology equivalent of Silicon Valley in Los Angeles said Mazziotta. Given the universitys expertise and state-of-the-art facilities we are expecting to attract the worlds best scientists"
X Link 2024-04-05T00:39Z [---] followers, [----] engagements
"Another deal on ADC. Seriously have we seen a single BP which hasn't had ADC in its portfolio. ADCs are bio missiles and IMO to make missiles hit targets--the cancer cells with high precision while leaving intact the healthy cells the precise target identification is the key. All the current ADCs are using pretty much the same targets. They will have a lot more if they use DCVax-L as a tool for target identification"
X Link 2024-04-05T16:17Z [---] followers, [---] engagements
"The interesting part is that this issue of Nature Outline was sponsored by Moderna. It has sort of commercial advertisement article by Moderna. But Nature presented two articles to give the audience a whole picture on cancer vaccine. I have to repeat this again. Look the number of tumor-associated peptides presented by MHC Class II molecules. No other companies on this planet can reach this breakthrough. I once picked up the peptide IDs listed in the figure and did the search in peptide database. No match cannot be found which means thy were unknown to human being before the ASCO presentation"
X Link 2024-04-06T17:12Z [---] followers, [----] engagements
"On Tuesday April [--] Rathmell will join a representative from the White House and other panelists to discuss the latest on President Joe Bidens Cancer Moonshot initiative. This major symposium The Cancer Moonshot: Opportunities to Fulfill the Vision of the National Cancer Plan will be held from 2:30 [--] p.m. PT in Room [--] on the upper level of the convention center. The Cancer Moonshot: Opportunities to Fulfill the Vision of the National Cancer Plan - Dedicated to the Memory of Senator Dianne Feinstein Description The Reignited Cancer Moonshot launched by President Biden seeks to mobilize"
X Link 2024-04-07T05:32Z [---] followers, [----] engagements
"@TimThomas0007 @apwriter It is a possible scenario which explains why Oncovir has on board a legal consultant with expertise on acquisition and exit in June [----]. https://www.oncovir.com/pusch-b https://www.oncovir.com/pusch-b"
X Link 2024-04-07T13:50Z [---] followers, [----] engagements
"Can we expect the exciting data on rGBM now since data on prostate caner is out "Our T cell expansion and tumor infiltration story is supported by additional data coming out in the next few weeks." President and Chief Operating Officer Matthew Vandermast highlighted the key attributes of Hiltonol a synthetic dsRNA designed to activate the bodys defense mechanisms against viruses and tumors. Oncovirs clinical targets are solid tumors and infectious disease indications including HIV and COVID. We have especially exciting data developing around recurrent glioblastoma and prostate cancer."
X Link 2024-04-11T23:43Z [---] followers, [----] engagements
"I don't know about CAR-T and I don't know the actual value of $NWBO either. Here Abbvie paid $10b for a company which only had one FDA approved drug for ovarian cancer treatment one year ago. $NWBO technology can treat all solid tumors. So at minimum $150b. But now with all the new input from RevImmune on HIV and other cancers even this number seems low. It seems like no BP can afford $NWBO. AbbVie pays $10B to acquire ImmunoGen doubling down on red-hot ADC cancer field https://www.fiercepharma.com/pharma/abbvie-pays-10b-acquire-immunogen-doubling-down-red-hot-adc-cancer-field"
X Link 2024-04-25T03:26Z [---] followers, [---] engagements
"@maveric92283613 Almost all the BPs have record revenue and in the meantime they all have massive layoffs including R&D to optimize prioritize and streamline their pipeline. As you mentioned before there is no coincidence"
X Link 2024-04-25T13:02Z [---] followers, [--] engagements
"@apwriter The interesting part is that Athenahealth is a private company. https://www.techtarget.com/searchhealthit/news/366578802/EHR-Vendor-athenahealth-Acquired-by-Hellman-Friedman-Bain-Capital https://www.techtarget.com/searchhealthit/news/366578802/EHR-Vendor-athenahealth-Acquired-by-Hellman-Friedman-Bain-Capital"
X Link 2024-05-08T17:36Z [---] followers, [--] engagements
"Note that NWBO licensed the DC vaccine technology. Competing interests Andres Salazar is the Founder CEO and Scientific Director for Oncovir which provided the TLR agonist (Poly-ICLC) used in the trial. Linda M. Liau is a member of the Scientific Advisory Board for Northwest Bioetherapeutics Inc which has licensed the DC vaccine technology. All others declare no competing interests"
X Link 2024-05-08T18:55Z [---] followers, [----] engagements
"We have a drug master file with the FDA and we have been in front of many of the worlds tier [--] regulatory agencies including the European Union Countries including France and Switzerland in addition to Canada Japan Brazil and Thailand. Our product is going to be able to be used around the world. Our big push is to get funding so that we can support the development of Hiltonol with our partners and get commercialized in one therapeutic area. https://gritdaily.com/cancer-therapy-oncovirs-hiltonol/ https://gritdaily.com/cancer-therapy-oncovirs-hiltonol/"
X Link 2024-05-08T21:47Z [---] followers, [----] engagements
"Use cell + oncology to search AZN job website there are [---] recent openings. https://careers.astrazeneca.com/search-jobs/cell%20%2B%20oncology/7684/1glat=30.51685905456543&glon=-86.48217010498047 https://careers.astrazeneca.com/search-jobs/cell%20%2B%20oncology/7684/1glat=30.51685905456543&glon=-86.48217010498047"
X Link 2024-05-10T19:42Z [---] followers, [---] engagements
"@apwriter Remind Roaring Kitty this billionaire is also a short seller of $NWBO. https://www.afr.com/companies/media-and-marketing/short-selling-media-company-long-odds-for-australia-20240407-p5fhyy https://www.afr.com/companies/media-and-marketing/short-selling-media-company-long-odds-for-australia-20240407-p5fhyy"
X Link 2024-05-14T22:05Z [---] followers, [---] engagements
"@dcvaxdaw @JPGarza84 @metacollectiveG They don't have leverage either. If they can get call options they will lose less. Did I get that right"
X Link 2024-05-15T05:46Z [---] followers, [---] engagements
"@patrickwalsh14 I suspect Madoff let his sons to turn him in"
X Link 2024-05-16T18:17Z [---] followers, [--] engagements
"MGMT is fabulous. It is a nonarugable fact. Did the Nature paper specifically mention that the technology employed was licensed by the company It used to be the norm that the company presented something at the Industry Expert Theater. I suspect they cannot do that this year because of pending approval"
X Link 2024-05-17T16:00Z [---] followers, [--] engagements
"This figure is one of my favorite from Dr. Liau's present. The green dots are tumor-associate macrophages coming to tumor site to suppress t cells which are the red dots. Have you checked some of the papers on how effectively plx3397 can deplete tumor-associate macophages I read some and it seems to me plx3397 as the only FDA approved oral CSF1R-I is highly effective. Imagine what would happen to those blue dots (cancer cells) if all the green dots are gone. Also the colorectal cancer also has immunosuppressive characteristic dominated by tumor-associated macrophages"
X Link 2024-05-18T03:41Z [---] followers, [---] engagements
"Qurient has the technology for the orally available immuno-oncology therapeutic small molecule targeting selectively Axl Mer and CSF1R originated from the Max Planck Institute of Biochemistry. The small molecule drug called Q702 is an orally available selective Axl/Mer/CSF1R triple kinase inhibitor showing significant in vivo activity as monotherapy as well as in combination with anti-PD-1 antibody. Q702 not only modulates innate immune components such as myeloid derived suppressor cell tumor associated macrophage in tumor micro-environment but also increases MHC I expression in tumor cell."
X Link 2024-05-24T20:31Z [---] followers, [---] engagements
"@olblue26 @Alex29617214 Well in this case for this particular you do need to appreciate. LP brought this company back from the verge of bankruptcy. If the management is garbage why are you still hanging around Find a greener pasture"
X Link 2024-05-28T16:14Z [---] followers, [---] engagements
"Naysayers keep saying that the collaboration trial on colorectal cancer between $NWBO and $MRK was cancelled and never happened. IMO the trial is real and most like the results must be great. Why The trial was still listed as one of research projects on the webpage of Johannes Gutenberg-Universitt Mainz in [----] the same year of the completion of the research project. More importantly based on the disclosure on the conflict of interest over the past ten years the PI of the trial professor Markus Moehler has been in close collaboration with Merck (MSD). There was no overlapping between him and"
X Link 2024-05-29T18:35Z [---] followers, [----] engagements
"@dcvaxdaw I suspect the [--] pts are for a company with mediocre science and definitely are not measures for an OTC company with revolutionary and disruptive science. It is just that simple"
X Link 2024-05-31T17:04Z [---] followers, [--] engagements
"@andrewcaravello Great stuff Andrew. I found one interesting sentence about in-situ vaccine. Does Direct fall into the category of in-situ vaccine https://www.nature.com/articles/d41586-024-01429-2 https://www.nature.com/articles/d41586-024-01429-2"
X Link 2024-05-31T19:21Z [---] followers, [---] engagements
"Trials on ADCs neoantigen therapy and small molecule drugs can have the risk of failure. DCVax-L has no such problems. Are the dendritic cells trained and educated by NWBO technology picky about the lysate types from different solid tumors I don't think so. Otherwise NWBO would have filed different patents for different solid tumors. One interesting thing about the collaboration trials between Merck and Moderna is that keytruda shows efficacy for all those targets in the collaboration trials and has FDA approval for those targets. They just want to see to what extent the efficacy will improve"
X Link 2024-06-05T00:38Z [---] followers, [----] engagements
"I don't think there will be p3 trial any more for DCVax-L. You can see Moderna is planning for approval based on a phase [--] trial. I don't see any reason NWBO cannot do the same. As for $20b or $80b how about going through what happened to the acquisition of Prometheus first Then give an estimate about NWBO. https://s21.q4cdn.com/488056881/files/doc_presentations/2023/04/Splash-Investor-Event-Slides-FINAL-1.pdf https://s21.q4cdn.com/488056881/files/doc_presentations/2023/04/Splash-Investor-Event-Slides-FINAL-1.pdf"
X Link 2024-06-10T00:20Z [---] followers, [---] engagements
"From ChatGPT about proteomics on antigen-presenting cells. A full proteomics analysis of antigen-presenting cells (APCs) can be quite time-consuming. The detailed steps involved and their associated time requirements are as follows: Sample Collection and Preparation: Cell Isolation: Isolating APCs (such as dendritic cells macrophages or B cells) from tissues or cell cultures can take several hours to a couple of days depending on the starting material and isolation method (e.g. flow cytometry sorting magnetic-activated cell sorting). Protein Extraction and Digestion: This involves lysing the"
X Link 2024-06-12T17:23Z [---] followers, [----] engagements
"@dcvaxdaw @alphavestcap Management did a fabulous job last year. Before the approal sp is the least we should care about. So Yes for all items"
X Link 2024-06-13T02:16Z [---] followers, [--] engagements
"I don't see how comparison can be made between the two. NWBO has been keeping such a low profile for many years and yet has been under constant attack. Recall two Harvard professors became so desperate that they abandoned their ethics and wrote a hitting piece published on Thanksgiving day. The piece had such a poor quality that they had to make correction later. Put your trust in the management. They are the ones who have been guarding NWBO and reached one milestone after another. Again how many years has Dr. Liau been collaborating with NWBO management Over [--] years. I am certain Dr. Liau"
X Link 2024-06-13T16:31Z [---] followers, [---] engagements
"@escctrl74 I voted the same. Even though I am a minnow I am so proud of swimming along with big whales"
X Link 2024-06-13T22:04Z [---] followers, [---] engagements
"@dcvaxdaw @olblue26 @metacollectiveG @justinkeister5 @tbinfo1 @maveric92283613 @ThomasOwenMcCa1 Are you serious Which part makes you think the company in crisis The company is perfectly fine. Everyone is waiting for the approval which will trigger chain reaction"
X Link 2024-06-14T02:55Z [---] followers, [---] engagements
"Since I am a half-full type of person. I would say SIO is a greedy friend. Does Labcorp account for the largest percentage in SIO's portfolio Labcorp is in the field similar to that of CRL. The company created a spin-off specifically focusing on CRO. SIO just reinvested in a company which is developing small molecule inhibitor to over immunosuppression. It seems like SIO is serious in Oncology. Why did SIO not buy C-shares I suspect LP didn't give SIO the option. 8m is the maximum number LP can offer. If SIO is a true believer in DCVax-L SIO has to load in the open market. Loaning out all the"
X Link 2024-06-14T16:07Z [---] followers, [--] engagements
"@dcvaxdaw @tbinfo1 @metacollectiveG @ABenS2060 @ThomasOwenMcCa1 @justinkeister5 I found the post. I thought you would have read it carefully. But it seems like you were in a hurry to utter your opinion about how you were going to vote. https://x.com/d_stock07734/status/1795886661412213037t=0jLbKdZye-CsPYzf5Sy0Fw&s=19 Naysayers keep saying that the collaboration trial on colorectal cancer between $NWBO and $MRK was cancelled and never happened. IMO the trial is real and most like the results must be great. Why The trial was still listed as one of research projects on the webpage of"
X Link 2024-06-14T22:52Z [---] followers, [---] engagements
"This is the trial that just started earlier this year. The clinical trial is led by Dr. Puzanov principal investigator with Pawel Kalinski MD PhD Chair Department of Immunology Chief of Translational Immuno-Oncology and Senior Vice President for Team Science at Roswell Park as laboratory lead. Dr. Kalinski also is the holder of a five-year $14.5 million National Cancer Institute-funded Program Project Grant involving Roswell Park the University of Pittsburgh Medical Center and Mt. Sinai School of Medicine that has led to the development of this form of immunotherapy for melanoma breast"
X Link 2024-06-17T14:48Z [---] followers, [----] engagements
"Pfizers Gene Therapy for Duchenne Muscular Dystrophy Fails Phase III Trial https://www.biospace.com/article/pfizer-s-gene-therapy-for-duchenne-muscular-dystrophy-fails-phase-iii-trial/ https://www.biospace.com/article/pfizer-s-gene-therapy-for-duchenne-muscular-dystrophy-fails-phase-iii-trial/"
X Link 2024-06-17T19:59Z [---] followers, [---] engagements
"Absolutely. For instance dendritic cells can be educated to treat HIV. The vaccine candidate is developed by the Vaccine Research Institute (VRI) with LinKinVax technology the first vaccine based on this technology targeting an immune response binding HIV envelope protein to monoclonal antibodies specifically targeting CD40 receptors on dendritic cells. The Env protein is injected and delivered directly to the dendritic cells. The vaccine is combined with the Hiltonol adjuvant designed to enhance its potential action. Professor Yves Lvy Executive Director of the VRI and CMSO of LinKinVax"
X Link 2024-06-18T21:49Z [---] followers, [---] engagements
"@peter_brit @justinkeister5 Thank you for being the inexhaustible source of information on NWBO. I didn't realize LabCorp had very high-caliber board members. The new board member is also on Merck's board. It is really a small world https://ir.labcorp.com/corporate-governance/board-of-directors https://ir.labcorp.com/news-releases/news-release-details/labcorp-appoints-dr-paul-rothman-board-directors https://ir.labcorp.com/corporate-governance/board-of-directors https://ir.labcorp.com/news-releases/news-release-details/labcorp-appoints-dr-paul-rothman-board-directors"
X Link 2024-06-19T17:40Z [---] followers, [----] engagements
"Dr. W. Kimryn Rathmell mentioned about pediatirc Ewing sarcoma. NCI did a trial using dendritic cell vaccine in combination with CYT107 eight years ago and the results are truly amazing. Previous Cancer Moonshot SM investments supported the Fusion Oncoprotein in Childhood Cancer Consortium which identified a new therapeutic target for Ewing sarcoma. https://www.cancer.gov/about-nci/budget/congressional-justification/fy2025-nci-congressional-justification.pdf https://clinicaltrials.gov/study/NCT00923351"
X Link 2024-06-21T03:41Z [---] followers, [----] engagements
"AbbVie's Humira loses some ground in high-stakes battle against biosimilars: report https://www.fiercepharma.com/pharma/shrinking-market-share-abbvies-humira-loses-ground-battle-against-biosimilars-report https://www.fiercepharma.com/pharma/shrinking-market-share-abbvies-humira-loses-ground-battle-against-biosimilars-report"
X Link 2024-07-12T21:03Z [---] followers, [---] engagements
"Here is the part from NWBO's PR on the challenge of isolating adherent dendritic cells without damage. The special difficulty involved in developing the Flaskworks machine was that unlike other cell types the dendritic cells tightly adhere to the surface of the culture vessel (similar to barnacles). Extracting them from inside the culture vessel without damaging the cells or reducing the yield of doses was extremely challenging. Other cells (including T cells) are generally cultured suspended in liquid in a bag which makes it much easier to move them through processes. Many companies have"
X Link 2024-07-15T14:50Z [---] followers, [----] engagements
"Amgen BMS and Merck have the most exposure as Big Pharma eyes $183B patent cliff: analyst https://www.fiercepharma.com/pharma/firepower-aplenty-and-patent-cliffs-ahead-time-right-ma-activity-report https://www.fiercepharma.com/pharma/firepower-aplenty-and-patent-cliffs-ahead-time-right-ma-activity-report"
X Link 2024-07-16T02:20Z [---] followers, [---] engagements
"Were curing people of diseases that we previously thought were absolutely intractable and not survivable said Karen Knudsen CEO of the American Cancer Society and the American Cancer Society Cancer Action Network. GBM is the most commonand most aggressivetype of cancerous brain tumor in adults. Individuals with GBM usually expect to live 12-18 months following their diagnosis. Despite decades of research there is no known cure for GBM and approved treatmentssuch assurgery radiation and chemotherapyhave limited effect in prolonging an individuals life expectancy. However even after aggressive"
X Link 2024-08-13T14:42Z [---] followers, [---] engagements
"@maxstradamus21 I suspect this is what platform technology is about. I have not included the value from supplying neo-peptides that can trigger antitumor immune response. Note that only far less 1% neo-peptides can trigger antitumor immune response"
X Link 2024-08-15T21:42Z [---] followers, [---] engagements
"@peter_brit @nipomo357 There is a possibility that some way this could be related to DCVax-L. Whttps://www.onclive.com/view/roswell-parks-dr-pawel-kalinski-to-lead-145m-ncifunded-immunotherapy-effort https://oncology.labcorp.com/cancer-care-team/news-events/labcorp-expands-oncology-portfolio-omniseqr-acquisition https://www.biospace.com/roswell-park-cancer-institute-spins-off-b-omniseq-b-genomics-firm https://oncology.labcorp.com/cancer-care-team/news-events/labcorp-expands-oncology-portfolio-omniseqr-acquisition"
X Link 2024-08-17T13:42Z [---] followers, [---] engagements
"@maveric92283613 @LuckyPenguin10 @biggercapital And look at which company is collaborating with $CLPT. https://www.amplify-bio.com/cns-drug-delivery-at-amplifybio/ https://www.amplify-bio.com/cns-drug-delivery-at-amplifybio/"
X Link 2024-08-17T19:02Z [---] followers, [---] engagements
"How many companies like Genentech will strike a franchise agreement with NWBO I suspect the technology must be so amazing. Otherwise they would not abandon their early-stage R&D. "How is Amgen using human genetic data to improve drug discovery and design Bradway observed that Amgen is the largest company using human genetic data to inform drug development thanks in large part to our deCODE genetics subsidiary. He explained the importance of this data by noting that even when candidate medicines show promise in preclinical research with non-human animals those models don't always replicate how"
X Link 2024-08-19T21:50Z [---] followers, [----] engagements
"@dcvaxdaw That was hilarious Have a great weekend"
X Link 2024-08-23T20:30Z [---] followers, [--] engagements
"McKesson Signs Agreement to Acquire Controlling Interest in Florida Cancer Specialists & Research Institutes Core Ventures https://investor.mckesson.com/news/financial-news/2024/McKesson-Signs-Agreement-to-Acquire-Controlling-Interest-in-Florida-Cancer-Specialists--Research-Institutes-Core-Ventures/default.aspx https://investor.mckesson.com/news/financial-news/2024/McKesson-Signs-Agreement-to-Acquire-Controlling-Interest-in-Florida-Cancer-Specialists--Research-Institutes-Core-Ventures/default.aspx"
X Link 2024-08-26T12:42Z [---] followers, [---] engagements
"Another round of layoff from Genentech and scientists are the layoff targets. Scientist roles will be the hardest hit per the filing but the layoff round will also include engineers managers analysts and one vice president. That research hasnt been fruitful for the biotech company the outlet reported failing to replicate the success of blockbuster Genentech cancer drugs like Avastin Rituxan and Herceptin. One week ago Genentech shut down cancer immunology research department. I suspect Genentech must have a clear idea about its future first before letting go its most valuable assets. The"
X Link 2024-08-28T02:52Z [---] followers, [----] engagements
"Illumina already sells a laboratory developed test for profiling cancer called TSO [---]. The product which targets [---] genes in tissue samples generated sales of more than $100 million in [----] Illumina CEO Jacob Thaysen said on an earnings call in February. Thaysen said the test was expected to have high double-digit growth into this year and we dont see any end to that right now. https://www.illumina.com/content/dam/illumina/gcs/assembled-assets/marketing-literature/tso-comp-us-datasheet-m-amr-01466/trusight-oncology-comprehensive-us-data-sheet-m-amr-01466.pdf"
X Link 2024-08-29T05:10Z [---] followers, [---] engagements
"@mightynio I have no clue about BNGO. Right now Illumina mentioned about about five hundred genes that are related to tumor. What I am curious about is that how soon the company is going to add more How could the company identify those mutated genes efficiently in the future"
X Link 2024-08-29T14:00Z [---] followers, [---] engagements
"@maveric92283613 @escctrl74 Another Volkswagen short squeeze Probably even bigger one"
X Link 2024-08-29T18:14Z [---] followers, [---] engagements
"Did you the following figure All sorts of immune cells were activated. The percentage of CD4 is higher than that of CD8. CD14 monocyte which would differentiate into tumor-associated macrophages and suppress anti-tumor immune response also accounts for a significant percentage. But CSF1R-I can inhibit the differentiation. NWBO has the technology that can cure the most difficult cancer"
X Link 2024-09-01T03:30Z [---] followers, [----] engagements
"The comment period on the draft of Platform Technology Designation Program for Drug Development ends on August [--] 2024"
X Link 2024-09-02T01:37Z [---] followers, [---] engagements
"Were working to invent a world where cancer isnt just treated but cured or even where some types are prevented from happening in the first place. According to waybackmachine the above was added on August [--] [----]. https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/ https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/ https://web.archive.org/web/20220807183803/https://www.merck.com/research/oncology/ https://www.merck.com/research/oncology/"
X Link 2024-09-04T16:20Z [---] followers, [---] engagements
"@apwriter Keytruda biosimilar is on the way. https://www.pharmaceutical-technology.com/data-insights/pembrolizumab-biosimilar-sandoz-group-melanoma-likelihood-of-approval/ https://www.lexology.com/library/detail.aspxg=37efda82-adde-46fa-a1af-ef53c48d6b8b https://www.clinicaltrialsarena.com/news/samsung-biopeis-keytruda-biosimilar-enters-phase-iii-trials/ https://www.pharmaceutical-technology.com/data-insights/pembrolizumab-biosimilar-sandoz-group-melanoma-likelihood-of-approval/ https://www.lexology.com/library/detail.aspxg=37efda82-adde-46fa-a1af-ef53c48d6b8b"
X Link 2024-09-04T18:45Z [---] followers, [---] engagements
"The potential is far beyond cancers. DCVax-L could be the key to treating most diseases. Can NWBO's technology educate and prime dendritic cells so that they can command immune cells to eliminate mutated genes that cause hear diseases and Alzheimer's It is possible. Can NWBO's technology identify the targets on super bugs that can be loaded on ADCs to treat bacterial infection In my wild thinking there is a possibility too. Immunology is the mediator of nearly all human diseases whether were talking about cancer or heart disease or Alzheimers Michelson said. The vision for this institute is"
X Link 2024-09-05T19:28Z [---] followers, [----] engagements
"@StonkMasterJ Patients with [--] types of cancers were treated through compassionate use program. "Most of them blockbuster drugs". Up to now most likely over one thousand GBM patients have received the treatments. And you are trying to put a price tag on such company. You cannot be serious"
X Link 2024-09-05T20:04Z [---] followers, [---] engagements
"SC Tecentriq from Roche is checking point inhibitor. Roche had the approval from UK EU Canada already. BMS has the PDUFA of their SC Opdivo on December [--]. Merck hasn't finished its clinical trials yet. Actually Merck did finish one. But Merck never publicized the results and the media has already questioned about it. I suspect pressure is mounting on Merck. https://www.barrons.com/articles/merck-stock-keytruda-cancer-trial-07d2979f https://www.barrons.com/articles/merck-stock-keytruda-cancer-trial-07d2979f"
X Link 2024-09-09T17:12Z [---] followers, [---] engagements
"Genentech's cancer restructure was made 'for scientific reasons': exec https://www.fiercebiotech.com/biotech/genentechs-cancer-restructure-was-made-scientific-reasons-execs https://www.fiercebiotech.com/biotech/genentechs-cancer-restructure-was-made-scientific-reasons-execs"
X Link 2024-09-10T20:55Z [---] followers, [----] engagements
"@patrickwalsh14 @DonDonjarvis101 @smith348572 @JAMA_current The other BPs are also going to hit patent cliff in four years. NWBO is not a company that Merck can afford now"
X Link 2024-09-10T21:59Z [---] followers, [---] engagements
"It is the technology that they can use "to build the immunology equivalent of Silicon Valley in Los Angeles" A first-of-its kind effort in California the nonprofit public-private partnership will leverage UCLAs existing strengths in clinical and biomedical scientific research across a range of disciplines. Top-flight scientists from UCLA and around the world will pursue new tools treatments and vaccines to address a variety of pressing health challenges including cancer infectious diseases allergies autoimmune disorders heart conditions immune factors associated with organ transplantation and"
X Link 2024-09-12T19:16Z [---] followers, [---] engagements
"@Hspooner665 See what kind of trials the company is running Is that interesting I think the therapy targets a specific gene called TNF. I could be wrong. https://www.inmunebio.com/index.php/newsroom/2024-news/muneioncnnouncesewhase1tudyataemonstrati20240729060507 https://www.clinicaltrialsarena.com/news/inmune-bios-unique-alzheimers-trial-endpoint-receives-validation/ https://www.inmunebio.com/index.php/newsroom/2024-news/muneioeportsignificantmprovementinlzheimer20240305050502 https://www.inmunebio.com/index.php/newsroom/2024-news/muneioncnnouncesewhase1tudyataemonstrati20240729060507"
X Link 2024-09-12T20:07Z [---] followers, [---] engagements
"To have a BO you have to put a price tag. How could you price something with unlimited potential As an illustration in ASCO presentation Dr. Bosch mentioned that peptides from viruses were also presented to the immune system. But he didn't mention if the viruses were eliminated. What if the current DCVax-L technology (maybe with some modifications) can treat infectious diseases like HIV or neurodegenerative diseases like Alzheimer's How could you handle the BO pricing about these two types of diseases New vaccine targeting toxic amyloid- could help halt Alzheimers disease progression"
X Link 2024-09-13T15:06Z [---] followers, [--] engagements
"@jman4956 @RBioceutics I doubt if anyone knows the answer. I wonder if this news has something to do with DCVax-L. If it does no way can someone assign a number to the value of NWBO. https://newsroom.ucla.edu/stories/ucla-research-park-immunology-and-immunotherapy https://newsroom.ucla.edu/stories/ucla-research-park-immunology-and-immunotherapy"
X Link 2024-09-14T18:36Z [---] followers, [---] engagements
"@TiltMyBrain Different tumors could have different immunosuppressive characteristics. We need an extra inhibitor to take care of immunosuppresion. We all know this for a fact. But I never feel tired of repeating it"
X Link 2024-09-19T19:44Z [---] followers, [---] engagements
"@MDendream I get my champagne ready for the fireworks show in a month. You are saying it will be next year. Don't burst my bubble"
X Link 2024-09-20T13:40Z [---] followers, [---] engagements
"The following are all the dendritic cell clinical trials sponsored by DoD. It seems like they all are connected to NWBO in some way. Did LP mention at ASM that NWBO has collaboration with academic institutions other than Roswell Park A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) Principal Investigator:Peter A Forsyth MDMoffitt Cancer Center Innovative Dendritic Cell Vaccine Trial Provides Hope for Breast Cancer Patients with Leptomeningeal Disease Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast"
X Link 2024-09-20T18:56Z [---] followers, [----] engagements
"A doctor journeys from still rings to brain tumors Dr. Robert Prins steps into the U Magazine spotlight. https://www.uclahealth.org/news/publication/doctor-journeys-still-rings-brain-tumors https://www.uclahealth.org/news/publication/doctor-journeys-still-rings-brain-tumors"
X Link 2024-09-20T19:00Z [---] followers, [---] engagements
"@GoldwaterF98498 In addition to cure cancer I picture in [--] years DCVAX-L technology will put a bio-valley at UCLA in good shape. The technology will be the fundamental platform used for the development of drugs and vaccines for both humans and mammals"
X Link 2024-09-21T22:20Z [---] followers, [--] engagements
"Is there another cancer vaccine better than DCVax-L which can present hundreds of tumor-associated antigens to immune system so that it can identify and wipe out cancer cells and trigger immune memory while sparing normal cells https://x.com/ScienceMagazine/status/1838662459151786088 A new generation of cancer-preventing vaccines could wipe out tumors before they form. Learn more on #WorldCancerResearchDay: https://t.co/505pC4yaf6 @NewsfromScience https://t.co/6BE5ZkgkW9 https://x.com/ScienceMagazine/status/1838662459151786088 A new generation of cancer-preventing vaccines could wipe out"
X Link 2024-09-24T20:07Z [---] followers, [----] engagements
"Thanks Peter Great post Take a look at the outcome measures. We can only find another trial on the whole website that adopts measures like these. It is the combo trial. Only the treatment that can activate massive and sustainable t-cell infiltration into tumor sites can be qualified for measures like these. One specific part I want to point out is the measure of gamma-infereon increase. Recall what was mentioned in the poly-iclc paper published on Nature Communications. The increase of this specific biomarker correlates with significant OS. It seems like the measure of this specific biomarker"
X Link 2024-09-29T13:22Z [---] followers, [----] engagements
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