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# ![@bryan_johnson Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::17468569.png) @bryan_johnson Bryan Johnson

Bryan Johnson, founder of Braintree and OS Fund, has been experimenting with taking X grams of magic mushrooms, specifically psilocybin, as part of a protocol to explore its effects on longevity. He has been documenting his experience on social media, sharing updates on his physical and mental state, and discussing the potential therapeutic benefits of psilocybin. Johnson's goal is to build a "moral framework" that bridges human and machine biology and intelligence, and he sees his experiments with psilocybin as part of this larger effort.

### Engagements: XXXXXXX [#](/creator/twitter::17468569/interactions)
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- X Year XXXXXXXXXXX +170%

### Mentions: XXX [#](/creator/twitter::17468569/posts_active)
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- X Month XXX +3.50%
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### Followers: XXXXXXX [#](/creator/twitter::17468569/followers)
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- X Week XXXXXXX +1.80%
- X Month XXXXXXX +8.20%
- X Months XXXXXXX +25%
- X Year XXXXXXX +89%

### CreatorRank: XXXXXX [#](/creator/twitter::17468569/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::17468569/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[countries](/list/countries)  [finance](/list/finance)  [social networks](/list/social-networks)  [technology brands](/list/technology-brands)  [travel destinations](/list/travel-destinations)  [celebrities](/list/celebrities) 

**Social topic influence**
[health](/topic/health) #749, [food](/topic/food) #2624, [if you](/topic/if-you), [flow](/topic/flow), [livestream](/topic/livestream) #62, [sunday](/topic/sunday) #1091, [level](/topic/level) #829, [stem](/topic/stem) #843, [robust](/topic/robust) #11, [sun](/topic/sun) #291

**Top accounts mentioned or mentioned by**
[@bryanjohnson](/creator/undefined) [@autismcapital](/creator/undefined) [@elonmusk](/creator/undefined) [@billym2k](/creator/undefined) [@grok](/creator/undefined) [@grimezsz](/creator/undefined) [@tr_babb](/creator/undefined) [@whoop](/creator/undefined) [@hubermanlab](/creator/undefined) [@mrbeast](/creator/undefined) [@balajis](/creator/undefined) [@greekgamblerpm](/creator/undefined) [@tiffanyfong](/creator/undefined) [@robertkennedyjr](/creator/undefined) [@basedbeffjezos](/creator/undefined) [@dunik_7](/creator/undefined) [@karpathy](/creator/undefined) [@chamath](/creator/undefined) [@mcdonalds](/creator/undefined) [@katetolo](/creator/undefined)
### Top Social Posts
Top posts by engagements in the last XX hours

"I reduced a cognitive decline marker by XX% using HBOT and sauna. Serum pTAU217 is a marker for Alzheimer's disease. A year ago my pTAU217 level was in the upper normal range at XXXX pg/mL (with XXXX pg/mL being a commonly used cut-off value). This was mildly concerning even in the absence of any signs of plaque in my routine brain MRI. Following XX HBOT sessions my pTAU-levels dropped by XX% to the mid-normal range at XXXX pg/mL. This improvement lasted over X months with continued HBOT and the addition of sauna to my morning routine. A few months ago I observed a further small improvement a"  
[X Link](https://x.com/bryan_johnson/status/1978926605360926885)  2025-10-16T20:50Z 762.2K followers, 133.1K engagements


"it officially hit"  
[X Link](https://x.com/bryan_johnson/status/1987597582097584501)  2025-11-09T19:06Z 762.1K followers, 2.2M engagements


"i'll start i went to bed XX minutes later than i should have last night because the family had to finish the 10th episode of dexter: resurrection"  
[X Link](https://x.com/bryan_johnson/status/1990210761294324026)  2025-11-17T00:09Z 762.1K followers, 109.4K engagements


"Blood draw today to create clones of myself and measure biomarkers for magic mushroom follow up. On my organoid clones: Blood sample collected for PBMCs which will be reprogrammed into induced pluripotent stem cells (iPSCs) to generate thousands of mini-livers and hearts. these organoids will be used for high-throughput screening of my longevity protocols. Goals are: + creating a digital avatar for drug/supplement distribution metabolism and toxicity. + detecting and eliminating hidden toxicities. + optimizing dosage and intervention combinations for maximum efficacy and minimal risk. My"  
[X Link](https://x.com/bryan_johnson/status/1990833391017865267)  2025-11-18T17:24Z 762.2K followers, 157K engagements


"wish for your enemy to stay up past their bedtime"  
[X Link](https://x.com/bryan_johnson/status/1992803195245208024)  2025-11-24T03:51Z 762.1K followers, 151.7K engagements


"its day X of our XX day sugar fast hows it going"  
[X Link](https://x.com/bryan_johnson/status/1992981805813903656)  2025-11-24T15:41Z 762.2K followers, 166.3K engagements


"Theres XX% more car crashes the day before Thanksgiving. Be vigilant and careful"  
[X Link](https://x.com/bryan_johnson/status/1993688797003805025)  2025-11-26T14:30Z 762.2K followers, 92.5K engagements


"Ilya and I are predicting the same future. @ilyasut predicts that as AI becomes viscerally powerful humans will change in unprecedented ways. Ive been arguing the same. We are not open to radical change yet because we cannot feel the pressure of AI. Once we do the vectors for human evolution will blow open. I have been building the prototype for this adaptation and opening. He argues that as risk rises rivals will begin cooperating on safety. Ive argued the same. As the stakes become existential the game shifts from dominance maximizing to minimizing death risk (survival). We will rebuild our"  
[X Link](https://x.com/bryan_johnson/status/1994180370422780027)  2025-11-27T23:03Z 762.2K followers, 564.8K engagements


"Because our world revolves around money weve built robust intuitions around discerning cost and value. We do not have the same refined intuitions in health: what kills us or makes us stronger. On health we obviously avoid that which kills us immediately but accept that which kills slowly. Sometimes because we are willing to make the trade of losing life for pleasure and other times because we just dont know or are not aware. This is on my mind because Im traveling at the moment and I now understand and see the world entirely through the lens of life and death. I see so clearly societal"  
[X Link](https://x.com/bryan_johnson/status/1997040580329873740)  2025-12-05T20:29Z 762.2K followers, 108.6K engagements


"In this article for live-streaming my mushroom trip I'm harpooned by several psychedelic insiders for "ego enrichment" "a circus of self-indulgence" and "digital narcissism". Here's what's going on: when someone violates a tribe's norms the tribe's priests don't try to understand the new behavior they seek to delegitimize the actor in order to protect their own status and try and claim superiority. By doing this they are confessing new boundaries of possibilities have been set and their inability to take a similar risk. If they can't win on position or strength they try to win on virtue. When"  
[X Link](https://x.com/bryan_johnson/status/1997087895027634533)  2025-12-05T23:37Z 762.2K followers, 231.2K engagements


"@paulsaladinomd I did four of these treatments and saw no significant difference in toxin levels"  
[X Link](https://x.com/bryan_johnson/status/1997127911787348324)  2025-12-06T02:16Z 762.2K followers, 739.4K engagements


"Thank you Singapore for the breathe of fresh air"  
[X Link](https://x.com/bryan_johnson/status/1838712054678720813)  2024-09-24T22:48Z 760.1K followers, 526.9K engagements


"resting heart rate before bed is the #1 indicator of great sleep"  
[X Link](https://x.com/bryan_johnson/status/1955429771565003203)  2025-08-13T00:42Z 760.8K followers, 124.4K engagements


"My bad posture almost killed me. We discovered that I have genetically narrow internal jugular veins and my posture was cutting off the flow of blood out of my brain and back to my heart. Even with normal jugular veins you may be doing the same by slouching. Studies found that looking down at a XX degree angle puts a XX lb load on your cervical disc. Instead: + hold your screen at eye level especially for long durations + prop up elbows + use a laptop stand or monitor instead of a phone when possible"  
[X Link](https://x.com/bryan_johnson/status/1973797247625408867)  2025-10-02T17:08Z 760.3K followers, 240K engagements


"A human premature egg just taught a skin cell how to divide like one. A milestone to lab-grown human eggs. What happened: the nucleus of adult skin cells (which contain the DNA) was placed in human premature eggs (metaphase oocytes) whose own nucleus was removed. Inside the oocyte cytoplasm the skin-cell DNA was forced through a process the authors deemed mitomeiosis. The eggs machinery coaxes a somatic nucleus to halve its chromosomes mimicking the initial division step of natural egg formation. A step towards possibly helping the following conceive: + cancer survivors + potentially same-sex"  
[X Link](https://x.com/bryan_johnson/status/1980776597990043781)  2025-10-21T23:21Z 760.4K followers, 66K engagements


"@SuhailKakar here are a few recipes:"  
[X Link](https://x.com/bryan_johnson/status/1993027541159100877)  2025-11-24T18:42Z 760K followers, 19.4K engagements


"a lot of people intensely want me to fail and I appreciate all of you who had my back on this"  
[X Link](https://x.com/bryan_johnson/status/1878837839988982254)  2025-01-13T16:13Z 761.1K followers, 979.2K engagements


"Avoid high intensity exercise X hours before sleep. It impairs sleep and recovery according to a new study. Study (from @WHOOP) found that late night exercise. - Delayed sleep onset - Shorter total sleep duration - Lower sleep quality - Higher resting heart rate (RHR) - Decreased heart rate variability (HRV) More details Sleep onset Even workouts ending X hours before bed delayed sleep if they were high or maximal strain. Maximal intensity at X hours before bed = 36-minute delay in falling asleep vs. light exercise. Sleep duration Exercise within XX hours of bedtime associated with shorter"  
[X Link](https://x.com/bryan_johnson/status/1914818988271657452)  2025-04-22T23:09Z 761.3K followers, 306.1K engagements


"The reason why it makes sense to build your life around sleep is because it's the master modulator of willpower motivation emotional regulation and mood stability. Without the power of sleep setbacks haters and the addiction economy will have their way with you"  
[X Link](https://x.com/bryan_johnson/status/1980681959706882081)  2025-10-21T17:05Z 761K followers, 210.3K engagements


"On @netflix Jan X 2025 is the year of dont die"  
[X Link](https://x.com/bryan_johnson/status/1866832888605598099)  2024-12-11T13:10Z 762.2K followers, 8.5M engagements


"Dont choke your partner during sex. A study tested XX college-aged women: half had been choked during sex 4+ times in the past month the other half hadnt. Women who were frequently choked had significantly higher levels of S100B (brain injury marker p = .002). This marker is often elevated in people with concussion brain swelling or blood-brain barrier damage. Here its elevated after repeated sexual strangulation"  
[X Link](https://x.com/bryan_johnson/status/1942650385774305508)  2025-07-08T18:21Z 762.2K followers, 2.9M engagements


"Most men think the average erect penis is XXX inches. Its not. That data is self-reported. The actual global average is XXXX inches (13.61 cm) according to a 2020 meta-analysis of XX studies. Heres how to collect your own penis size data accurately"  
[X Link](https://x.com/bryan_johnson/status/1950974686260863380)  2025-07-31T17:39Z 762.2K followers, 227.5K engagements


"Health is forgotten until its the only thing that matters"  
[X Link](https://x.com/bryan_johnson/status/1972674688087445603)  2025-09-29T14:47Z 762.2K followers, 343.4K engagements


"Don't Die food guide"  
[X Link](https://x.com/bryan_johnson/status/1973525267877667239)  2025-10-01T23:07Z 762.1K followers, 141.5K engagements


"Most of the hate I get is understandable. Wealthy guy doing unusual things for health. Looks weird. Acts weird. Says weird things. Ok. Theres also something else going on. Ultraprocessed foods emerged in the 1970s. Those in adolescence / early adulthood (now 50-64) exposed to these foods now have nearly 2x the food addiction rates than the generation immediately preceding them (now 65-80). More than half of U.S. calories now come from ultra-processed foods: XX% for adults and XX% for youth. Contending only with tobacco and ultra-processed foods now seems quaint. In recent decades the most"  
[X Link](https://x.com/bryan_johnson/status/1977139591280050561)  2025-10-11T22:29Z 762.2K followers, 879.3K engagements


"People are confused by me and my intentions. Im called a narcissist a tech bro vampire grifter and health freak. Let me be clear about what Im doing: my goal is to build the worlds next major moral framework. An ideology that bridges human and machine biology and intelligence the ancient and the emergent. The coming psychosis A real possibility in the coming years is that society becomes dangerously psychotic. Yes we are already psychotic. Addicted fragmented and self-destructive. But I mean clinically psychotic and on a civilizational scale. We are already showing precursor symptoms: record"  
[X Link](https://x.com/bryan_johnson/status/1979631886415880350)  2025-10-18T19:33Z 762.1K followers, 406.3K engagements


"If you struggle with impulse control do this 10x a day to make your brain stronger: + notice the impulse to check your phone + deny the request + wait XX min before opening Start with XX reps a day and youll feel: + heightened will power + stronger self mastery + deeper self-respect People check their phones 150x daily. And spend X hrs XX min/day. The Addiction Economy who is your invisible enemy has hijacked your reward system. The anticipation of a notification spikes dopamine in your nucleus accumbens activating craving while reducing activity in the prefrontal cortex the brain region"  
[X Link](https://x.com/bryan_johnson/status/1982491285987656030)  2025-10-26T16:55Z 762.1K followers, 672.3K engagements


"We just raised $XX million for Blueprint. To bring my longevity protocol to you. Our society has made us unwellmetabolically mentally spiritually. Were addicted. Social media porn nicotine junk food fast food smartphones streaming energy drinks and gambling. Each perfectly engineered to keep us in their grip. Years ago I was owned by these systems. They wrecked me and my health. I wish there had been someone in my life helping me break free. Blueprint will be that system. Collectively we will claw our power back. Blueprint will take better care of people than they can themselves. Better than"  
[X Link](https://x.com/bryan_johnson/status/1983196154490966322)  2025-10-28T15:36Z 762.2K followers, 1.4M engagements


"When I think from the perspective of those living in the year 2500 I imagine theyll look back on the 2020-2030s as the moment humanity realized they were the first generation who wouldnt die"  
[X Link](https://x.com/bryan_johnson/status/1983545463551971749)  2025-10-29T14:44Z 762.1K followers, 204.9K engagements


"Boost self confidence + energy this week: + in bed same time daily + final food X hr before bed + screens off XX min before bed + book in hand XX min before sleep + 10000 lux or sun in eyes in am + XX min exercise daily + score 5/5 days"  
[X Link](https://x.com/bryan_johnson/status/1985406989078577424)  2025-11-03T18:01Z 762.1K followers, 253.2K engagements


"UPDATE 5: ok I am giving Bryan back his phone Please have fun w his after glow"  
[X Link](https://x.com/bryan_johnson/status/1987680650456113452)  2025-11-10T00:36Z 762.2K followers, 2M engagements


"Some are misunderstanding this post. It's affectionate teasing. The insult acts as a trust signal as you'd never actually say this to a stranger. Evidence shows teasing among friends correlates with higher social bonding trust and emotional intelligence. It's real sincerity"  
[X Link](https://x.com/bryan_johnson/status/1988020419526619483)  2025-11-10T23:06Z 762.1K followers, 650K engagements


"time to check inhows everyone doing sleeping exercising eating well.going through a rough patch or are things good tell me whats going on"  
[X Link](https://x.com/bryan_johnson/status/1988588190169694354)  2025-11-12T12:42Z 762.1K followers, 527.7K engagements


"Was cool to see reversing aging be a topic of discussion in D.C. yesterday. Hosted by @RobertKennedyJr our panel was U.S. Deputy Secretary of Health and Human Services Jim ONeill @HHS_Jim New Limit co-founder @byersblake and Neuralink co-founder and president @djseo. The U.S. is lucky to have someone like Jim in this position. Hes long been deep in rejuvenation science and other related technologies which hold great promise to improve human well-being. Blakes company New Limit is working on biotechnology that may enable us to reverse our age. They may be the GLP-1 equivalent of anti-aging the"  
[X Link](https://x.com/bryan_johnson/status/1988945344122470489)  2025-11-13T12:21Z 762.2K followers, 150.1K engagements


"My fertility markers are at an all-time high. I have more total and motile sperm than XXXX% of men of any age including men under XX. + total count: XXX M + concentration: XXX M + motility: XX% + total motile count: 330M + morphology (normal): XX% This is also more than 6x the needed motile count for pregnancy. Sauna without icing severely reduced my fertility markers. After reintroducing cooling they fully rebounded and rose to levels higher than before. Possibly contributing to the increase is my near complete elimination of microplastics from my blood and ejaculate and a dramatic"  
[X Link](https://x.com/bryan_johnson/status/1989381729841455376)  2025-11-14T17:15Z 762.2K followers, 135.2K engagements


"all you mfs who defend death as a virtue will need to delete your shit and pretend you never stood for it when we get our first GLP-1 equivalent for age reversal. you'll be body positivity for death"  
[X Link](https://x.com/bryan_johnson/status/1989823472172949958)  2025-11-15T22:30Z 762.1K followers, 668.8K engagements


"Ive felt kid-like excitement all week. That low-hum vibration the tickle in the body the thrilling anticipation. What you feel right before your first kiss. I dont recall feeling this for a very long time. Maybe 15-20 years or more Everything is more interesting and fun. Im eager to play and mess around. Less activation energy is required to do things. Life feels lighter and more interesting. This squares with my brain data. My default mode network is still inhibited the brain system that reinforces rigidity and done-it-all novelty exhaustion boring adult mode. My brain patterns show a higher"  
[X Link](https://x.com/bryan_johnson/status/1989833675224310169)  2025-11-15T23:11Z 762.1K followers, 899K engagements


"80% of the ocean remains unmapped or unexplored. Only 240k of est 2.2m marine species are identified. Kelp forests use a language we barely understand; hosting hundreds of interdependent species. For all the unknowns it feels deeply familiar. A majestic curious mystery"  
[X Link](https://x.com/bryan_johnson/status/1989865554166034550)  2025-11-16T01:18Z 762.2K followers, 284.1K engagements


"my mcdonald's breakdown is now the second best performing video on my youtube channel. next up: taco bell"  
[X Link](https://x.com/bryan_johnson/status/1990072377032482895)  2025-11-16T15:00Z 762.1K followers, 182K engagements


"hey guys it's me again reminding you that you're gonna kick ass this week. X. final meal X hrs before bed X. in bed same time every day X. screens off XX min before sleep X. read a book XX min before sleep X. block fast food X. tell someone u love them X. am light in eyes"  
[X Link](https://x.com/bryan_johnson/status/1990217621527277900)  2025-11-17T00:37Z 762.1K followers, 812.4K engagements


"I spent time in China last year and theyre hungry for longevity. Im going back again. This time to open our first two Blueprint longevity clinics and host a Dont Die Summit. Dec X in Shanghai + Dont Die Summit (full-day event) + VIP Dont Die Dinner Dec 11-13 in Chongqing + 11th longevity clinic opening Chongqing + Beijing + 12th women longevity event + 13th VIP Dont Die Dinner china at bryanjohnson dot com"  
[X Link](https://x.com/bryan_johnson/status/1991986599241089210)  2025-11-21T21:46Z 762.2K followers, 184.6K engagements


"starting a new protocol"  
[X Link](https://x.com/bryan_johnson/status/1992035301523702205)  2025-11-22T01:00Z 762.1K followers, 2.2M engagements


"eat these sugars: blueberries blackberries raspberries strawberries cherries apples kiwi pomegranate etc. avoid these sugars: cookies pies cakes sweet drinks chocolates cocktails anything with added sugar"  
[X Link](https://x.com/bryan_johnson/status/1992987164767125507)  2025-11-24T16:02Z 762.2K followers, 87.4K engagements


"what I'm eating this morning longevity score 1-10 + gemini: XX + gpt: XXX + grok: XXX + claude: 9.5"  
[X Link](https://x.com/bryan_johnson/status/1993017827931177043)  2025-11-24T18:04Z 762.2K followers, 298.2K engagements


"Here is what they found Daily GLP1-RA dosing for XX weeks (7.5 months) starting at XX months of age (equivalent 40s-60s in humans) Daily GLP-1RA dosing for XX weeks (7.5 months) starting at XX months of age in male mice a middle-aged time point in this strain. Counteracted age-related decline in forelimb grip strength and rotarod performance and improved spatial learning in aged mice without detectable changes in body weight food intake fasting blood glucose or spontaneous activity at this low dose (supporting an effect that is largely independent of weight loss or overt metabolic changes)."  
[X Link](https://x.com/bryan_johnson/status/1993114588477636827)  2025-11-25T00:28Z 762.2K followers, 39.9K engagements


"This Thanksgiving break I'm working on building out a new human archetype: warriors and caretakers of existence. A foundational layer for the Don't Die ideology. What should I be learning to prepare me for this"  
[X Link](https://x.com/bryan_johnson/status/1993779109546349038)  2025-11-26T20:29Z 762.1K followers, 79.7K engagements


"did pre-game prep with full morning routine: 4+ hr restorative sleep zero sleep stress mediation nutrition exercise sauna hbot and reading mean tweets"  
[X Link](https://x.com/bryan_johnson/status/1994884666994954624)  2025-11-29T21:42Z 762.2K followers, 109.5K engagements


"im intention setting for tomorrow what do you advise"  
[X Link](https://x.com/bryan_johnson/status/1994897993296904637)  2025-11-29T22:35Z 762.2K followers, 148.5K engagements


"hi friends experiencing some technical difficulties be on soon"  
[X Link](https://x.com/bryan_johnson/status/1995193416746217660)  2025-11-30T18:09Z 762.2K followers, 139.3K engagements


"good morning everyone. doing the XXXX grams of mushrooms yesterday was one of the best days of my life. it was healing energizing and full of love. the coolest thing was doing this together from the livestream crew and my team to so many of you we had a deeply impactful shared experience. my phone has been blowing up. many tell me they called their parents children and friends to express love and gratitude. that they have a renewed energy for health and life. life feels so fresh. i sincerely wish all the best for each of you. life is very hard and everyone is trying their best. we also make"  
[X Link](https://x.com/bryan_johnson/status/1995523369194942751)  2025-12-01T16:00Z 762.2K followers, 1M engagements


"@MichaelDell Michael this is amazing. Such a powerful signal to these kids that someone they can look up to is rooting for their success and in their corner"  
[X Link](https://x.com/bryan_johnson/status/1995943505131438189)  2025-12-02T19:49Z 762.2K followers, 146.5K engagements


"GuysI have a girlfriend. Now I know what youre thinkinghow is it possible that anyone would want to be with me I understand where youre coming from. I think the answer is: her puzzle piece fits mine. In my early twenties I read the biography of the American founding father John Adams. He and his wife Abigail had one of the great partnerships in American history; intellectually matched emotionally intertwined and co-architects of something bigger than themselves. I wanted what they had. But it wasnt within reach. Years before Id married in a sort of arranged Mormon marriage. Unsure how else to"  
[X Link](https://x.com/bryan_johnson/status/1995953490930401334)  2025-12-02T20:29Z 762.2K followers, 17.9M engagements


"Waking body temp today: 95.1F My body is cold as ice but my heart is warm. Low resting temp is a biomarker of slowed metabolic aging highly efficient metabolism low systemic inflammation stable glucose deep circadian alignment and reduced all-cause mortality"  
[X Link](https://x.com/bryan_johnson/status/1996256928524296255)  2025-12-03T16:35Z 762.2K followers, 166.3K engagements


"5.24g of mushrooms left measurable physiological and emotional fingerprints on my body. This is a first-of-its-kind face and body thermal map of a psychedelic experience. Notes: 1) my core body temp increased 1.5-2F (1C) matching human studies in which XX mg psilocybin raises temperature by 1.8F (1.0C). 2) my upper chest and throat increased 2.5F (1.4C) producing a thoracic heat bloom visible in the thermal image. 3) my nose and lips cooled significantly showing emotional intensity sadness and arousal. 4) my cheeks warmed showing joy connection happiness and subtle sadness. 5) my forehead"  
[X Link](https://x.com/bryan_johnson/status/1996300695163830750)  2025-12-03T19:29Z 762.2K followers, 602K engagements


"Three exciting longevity results came back from my first dose of mushrooms: XX% decrease in inflammation a deeply relaxed state and neuroprotective effects. Inflammation (hsCRP) My systematic inflammation levels dropped from elite to undetectable. This decrease is significant aligning with clinical reports of reduced inflammation markers (CRP TNF-alpha and IL6) seven days post high dose psilocybin. + pre-mushrooms: 0.23mg/dL + post-mushrooms: detection limit 0.15mg/dL + XX% decrease Deep low stress state (HPA Axis) My cortisol and DHEA-S dropped by XX% and XX% respectively suggesting a"  
[X Link](https://x.com/bryan_johnson/status/1996426120212910150)  2025-12-04T03:47Z 762.2K followers, 299.3K engagements


"@rickygervais Ricky in 2026 lets do the #mortality x #dontdie tour"  
[X Link](https://x.com/bryan_johnson/status/1996680748691259854)  2025-12-04T20:39Z 762.2K followers, 32K engagements


"Its inevitable that existence becomes the worlds reserve currency. The crossover will happen soon"  
[X Link](https://x.com/bryan_johnson/status/1997450099069456490)  2025-12-06T23:36Z 762.2K followers, 176.9K engagements


"A single night of XX hrs sleep reduces cognition by 2040% drops glucose stability by 3040% increases accident risk by XXX% elevates inflammatory markers 50100% impairs memory consolidation by 4060%. Most mental health problems are downstream this system level deregulation"  
[X Link](https://x.com/bryan_johnson/status/1997950161994260653)  2025-12-08T08:43Z 762.2K followers, 827.5K engagements


"A strong primary relationship is a longevity drug with GLP-1-like effects. + 12-15% less body weight + brain upgrade for stronger appetite control + improved gut-brain for neuroprotective metabolites and away from toxins The quality of your closest relationship may shape your biology as much as sleep or nutrition. Study limitations: The low sample size (94 participants only XX of whom were married) a high rate of overweight and obesity in the group and a relatively higher average BMI in the married group (34.2 for married vs. XXXX for unmarried) all limit the confidence in attributing effects"  
[X Link](https://x.com/bryan_johnson/status/1998148615660073407)  2025-12-08T21:52Z 762.2K followers, 102.8K engagements


"feel great look great and be great this week: + final food X hr before bed + screens off 30-60 min before sleep + read a book for XX min before sleep + wake up light in eyes (10k lux or sun) + exercise at least XX min + you're better than fast/junk food"  
[X Link](https://x.com/bryan_johnson/status/1998158547809677615)  2025-12-08T22:31Z 762.2K followers, 303.2K engagements


"@lady_valor_07 He doesnt have ejaculate microplastics He has DNA age XX He sleeps He exercises He cleans air and water He stands tall"  
[X Link](https://x.com/bryan_johnson/status/1998470927609376959)  2025-12-09T19:12Z 762.2K followers, 89.8K engagements


"Genetically I should be bald. I started to lose my hair and go gray in my late 20s. Now at XX Ive got a full head of hair and XX% of my gray is gone. Here how I did it. 🧵"  
[X Link](https://x.com/bryan_johnson/status/1848809345313649126)  2024-10-22T19:31Z 762.1K followers, 6.7M engagements


"There's now an active betting market on @Polymarket for my nighttime erections. A few things to consider when making your wager: + I return from China on the 16th of Dec and measurement will take place during the final week of the month. I've not previously measured how much international travel affects NTE however I know from casual observation that it significantly decreases them. The body get's pretty messed up with such a large time zone change. It's TBD how long it takes my body to adjust normal NTE. + My baseline NTE measurement was two hours and XX minutes (ave for a XX yr old). My"  
[X Link](https://x.com/bryan_johnson/status/1866608220128809402)  2024-12-10T22:17Z 761.6K followers, 1.1M engagements


"My HBOT protocol: . session XX today (60 total) . total time in chamber 4470 min . X ATA . XX min XXX% oxygen X min break . chamber by @hpotech_medical . will complete post therapy measurements this thursday . my max HR has increased by 15%"  
[X Link](https://x.com/bryan_johnson/status/1878183234225545545)  2025-01-11T20:52Z 761.7K followers, 342K engagements


"I don't eat red meat. This is why. You can eat meat. I'm cool with that"  
[X Link](https://x.com/bryan_johnson/status/1880016353731719643)  2025-01-16T22:16Z 761.9K followers, 1.7M engagements


"Even if you dont get it your kids will"  
[X Link](https://x.com/bryan_johnson/status/1880351378947862591)  2025-01-17T20:27Z 762K followers, 326.2K engagements


"Moved my office into my hyperbaric oxygen chamber"  
[X Link](https://x.com/bryan_johnson/status/1893010094251745351)  2025-02-21T18:49Z 762.1K followers, 16.4M engagements


"You can start your party at X pm instead of X pm and be just as cool"  
[X Link](https://x.com/bryan_johnson/status/1900542364948578606)  2025-03-14T13:39Z 762.1K followers, 2.7M engagements


"Israel assessed that Irans organized matter created a risk to its organized matter. Israel then used its organized matter to disorganize Irans matter"  
[X Link](https://x.com/bryan_johnson/status/1933532466414797202)  2025-06-13T14:30Z 761.9K followers, 218.8K engagements


"Throw it in the trash. You're not hungry"  
[X Link](https://x.com/bryan_johnson/status/1934374115085033938)  2025-06-15T22:15Z 762.1K followers, 375.9K engagements


"Brush your teeth immediately when you wake up. Overnight your mouth fills with acid-producing bacteria due to lower salivary flow. When you eat or drink carbs or sugars without brushing first you feed this bacteria which immediately producing acids acidity increases beyond the tolerance threshold and immediately starts damaging your enamel. Also an epidemiological 2010 study linked poor oral hygiene to higher levels of systemic inflammation and increased cardiovascular risk due to the spread of oral pathogens into the bloodstream. A 2020 nationwide study in Korea following 161286 subjects for"  
[X Link](https://x.com/bryan_johnson/status/1937641637091639568)  2025-06-24T22:39Z 762.1K followers, 1.3M engagements


"This morning I discovered the towel Ive been taking into the sauna is XX% cotton and XX% polyester. In my effort to detox I've accidentally been rubbing plastic on my body. I hope this brings you some joy"  
[X Link](https://x.com/bryan_johnson/status/1941913033452011800)  2025-07-06T17:32Z 762.1K followers, 1M engagements


"0/ What the product has: + X biomimetic peptides more than any other product. And in the highest concentrations. + We put every peptide in its own patented delivery system so it reaches the exact receptor its designed to target for maximum impact. + We integrated patented nanofluorosome technology that is activated by the Blueprint Laser Cap (avail in Sept). The serum is water-based lightweight and dries completely residue free. Layers of interventions and actives stacked upon each other"  
[X Link](https://x.com/bryan_johnson/status/1958233603495883205)  2025-08-20T18:24Z 762.1K followers, 134K engagements


"Defeating death would be humanity's greatest accomplishment"  
[X Link](https://x.com/bryan_johnson/status/1960742139366924737)  2025-08-27T16:32Z 762.1K followers, 3M engagements


"People once trembled at lunar and solar eclipses. Kings staged sacrifices crowds beat drums all to fight shadows they couldnt understand. Death is our modern eclipse. We fear it surrender to it ritualize it. Soon as our knowledge advances fearing death will seem as absurd as fearing the Moons shadow"  
[X Link](https://x.com/bryan_johnson/status/1964765674569613534)  2025-09-07T19:00Z 762.1K followers, 141.2K engagements


"Imagine someone has never experienced anxiety. How would you explain it"  
[X Link](https://x.com/bryan_johnson/status/1966911120146612407)  2025-09-13T17:05Z 762.1K followers, 575.7K engagements


"Fertility is down XX% in the past XX years. Whats the solution"  
[X Link](https://x.com/bryan_johnson/status/1969221724886442314)  2025-09-20T02:07Z 762.1K followers, 2.1M engagements


"A new longevity stem cell therapy in monkeys showed an estimated XX yrs of biological age reversal across XX% of tissues. Scaled cautiously to humans could correspond to XXX years of rejuvenation. If this replicates it's a big deal. 🧵"  
[X Link](https://x.com/bryan_johnson/status/1974107386827977011)  2025-10-03T13:40Z 762.1K followers, 292.3K engagements


"Japan has XX centenarians per 100k people The U.S. is XX per 100k What explains the difference"  
[X Link](https://x.com/bryan_johnson/status/1974247038708531314)  2025-10-03T22:55Z 762.2K followers, 1.1M engagements


"Here is some motivation to never eat McDonalds again. Scientific studies link ingredients like trans fats AGEs and high sugar loads to increased risk of heart disease cancer and metabolic dysfunction. 1) The burgers and fries are loaded with trans fats aldehydes and advanced glycation products (AGEs) which are associated with increasing the risk of heart disease and cancer while accelerating aging throughout your body. 2) TBHQ a preservative used in their frying oils has been described in laboratory and animal studies as a DNA-damaging compound that can suppress immune cell activity. While"  
[X Link](https://x.com/bryan_johnson/status/1974594262298927113)  2025-10-04T21:55Z 762.1K followers, 82.8K engagements


"GLP-1s raise your resting rate which can degrade sleep quality and lower HRV. I microdosed Tirzepatide (0.5mg/day) and it increased my RHR by X bpm and lowered my HRV by X. + Liraglutide: +610 bpm + Semaglutide: +24 bpm + Tirzepatide: +1.53.5 bpm Good to know in case youre wondering why your heart rate is higher or your sleep a bit worse"  
[X Link](https://x.com/bryan_johnson/status/1975322172345421951)  2025-10-06T22:08Z 762.1K followers, 692.9K engagements


"For those of you who want to rebel against societal addictions and reclaim yourself join me this week: X. final food X hr before bed X. screens off XX min before sleep X. read book in hand XX min before bed The self respect will feel amazing. Commit with a like tell me how you did when I post again about this on Saturday. Eating earlier will lower your resting heart rate which will boost your sleep. High quality sleep boosts your will power. Will power boosts good decision making everywhere. Late night eating increases blood glucose insulin and core body temp suppressing melatonin release."  
[X Link](https://x.com/bryan_johnson/status/1977793059816652840)  2025-10-13T17:46Z 762.1K followers, 221.8K engagements


"what i'm eating this week"  
[X Link](https://x.com/bryan_johnson/status/1978984465390043237)  2025-10-17T00:40Z 762.1K followers, 1.1M engagements


"I eliminated XX% of microplastics from my ejaculate. Nov 2024: XXX particles/mL July 2025: XX particles/mL Nearly identical drop in my blood same time period: Oct 2024: XX particles/mL May 2025: XX particles/mL Important as a meta-analysis of XX studies reveals that microplastics induce oxidative stress in the male reproductive system leading to testicular inflammation cell death and reduced testosterone levels sperm production and motility. Two studies last year showed that microplastics were detected in every human testicular and semen samples tested. The therapy we think most responsible"  
[X Link](https://x.com/bryan_johnson/status/1980693126391218482)  2025-10-21T17:50Z 762.2K followers, 4.4M engagements


"* a reverse osmosis water system is good to filter out microplastics. Sorry for botching that sentence"  
[X Link](https://x.com/bryan_johnson/status/1980698818250498502)  2025-10-21T18:12Z 762.1K followers, 161.5K engagements


"below is what the company says it does. I test the water monthly and it performs to spec: "This nine-stage reverse-osmosis system progressively purifies and polishes tap water. A sediment filter first strains out large particles followed by a carbon block that removes chlorine volatile organic compounds and odors. The 75-gallon RO membrane then eliminates 9598 % of dissolved impurities while a permeate pump improves efficiency and extends filter life. Purified water is stored in a 3-gallon non-electric holding tank for on-demand use. Two de-ionization filters further strip out nearly all"  
[X Link](https://x.com/bryan_johnson/status/1980701326180049359)  2025-10-21T18:22Z 762.1K followers, 79.1K engagements


"This is exciting.5-MeO-DMT just got FDA breakthrough designation for treatment resistant depression. XXX ppl with moderate-to-severe depression XX sites X countries Patients received either XX mg (n=73) X mg (n=46) or a low-dose comparator of XXX mg (n=74) which served as a placebo control. Efficacy Findings + at day XX post-dosing a single XX mg dose reduced depression scores by XXXX points (MADRS scale 0-60) compared to a 5.8-point reduction with the low XXX mg dose. + the X mg dose demonstrated equivalent efficacy suggesting its potential sufficiency for therapeutic benefit. + effects of"  
[X Link](https://x.com/bryan_johnson/status/1981806839504462009)  2025-10-24T19:35Z 762.1K followers, 412.8K engagements


"a little something to take the edge off"  
[X Link](https://x.com/bryan_johnson/status/1981861845611978922)  2025-10-24T23:14Z 762.1K followers, 554.7K engagements


"Im going to test psilocybin as a longevity therapy"  
[X Link](https://x.com/bryan_johnson/status/1982826028641947819)  2025-10-27T15:05Z 762.2K followers, 861.2K engagements


"This halloween am thinking I'll help kids test their blood glucose so that they can learn about the cause and effect relationship of sugar"  
[X Link](https://x.com/bryan_johnson/status/1983708255164756082)  2025-10-30T01:31Z 762.1K followers, 333.6K engagements


"One of the best things you can do for yourself is to get custom molded hearing aids. Take them with you everywhere you go. Modern society is way too loud wrecking our hearing. Wear your hearing protection at social gatherings restaurants concerts movies etc. You will be surprised to learn how frequently you're exposed to hearing-loss induced environments. You dont want hearing loss. It will cause your brain to shrink at around 1.3x the speed. It increases dementia risk by 2-5x depending on severity. It can also lead to depression social isolation and mortality. If you want to build your"  
[X Link](https://x.com/bryan_johnson/status/1983961152351830390)  2025-10-30T18:16Z 762.1K followers, 155.3K engagements


"I'm going to test psilocybin as a longevity therapy. Here's my protocol. In recent studies psilocybin improved survival in aged mice and increased cellular lifespan in human fibroblasts. My protocol: + X grams dried mushrooms monthly for X months. + This is equivalent to 25-50 mg of psilocybin. + before during and after brain measurements with the brain interface @KernelCo Flow Measurement To assess efficacy for cellular systemic and brain rejuvenation I will measure: + DNA methylation: speed of aging organ ages including the brain + telomere length and relative telomerase activity (RTA): the"  
[X Link](https://x.com/bryan_johnson/status/1983977081341145180)  2025-10-30T19:19Z 762.1K followers, 217.4K engagements


"Im going to build an organoid avatar of myself. Thousands of miniature Bryan Johnsons grown on cell culture dishes each replicating my cellular and organ biology. This living model will let me test the efficacy of supplements drugs and nutrition to accelerate safe and measure progress against aging. Details: The potential of stem cell derived organoids is to enable toxicity screenings for drug discovery and complex treatment regiments. This same benefit can be realized for longevity supplementation nutrition and Rx protocols. Becoming the most measured person in history allowed my organs to"  
[X Link](https://x.com/bryan_johnson/status/1985867798581801187)  2025-11-05T00:32Z 762.1K followers, 772.8K engagements


"My bedtime has arrived. Here's what's going to happen. After I finish writing this post screens are off. Wash face. Clean mouth. Hair serums. While listening to An Immense World. Will sit on my couch and process the day. Need to listen to all the Bryan's and what's on their minds. I hung out with @ChrisWillx today on his podcast. That Bryan is going to want to remind me about all the stupid stuff I said and the clips that Chris and team will cut where I'll look like an idiot. I'm going to tell that Bryan that it's ok. We've said stupid stuff before and it was fine. But thanks for the"  
[X Link](https://x.com/bryan_johnson/status/1986649674623951125)  2025-11-07T04:19Z 762.1K followers, 736.1K engagements


"Doing magic mushrooms this Sunday. Protocol + dose: X grams + frequency: 1x/mo for X mo + objective: exploring longevity effects Measurement + XXX independent biomarkers + XX vials of blood + brain scans + urine stool saliva fertility + multi-omics profiling (DNA epigenetics metabolism hormones microbiome proteins cognition) Cardiovascular + LDL-C + HDL-C + Triglycerides + Total cholesterol + Apolipoprotein B + Apolipoprotein A-1 + Lipoprotein(a) + LDL-P + HDL-P + Small LDL-P + LDL size + Large VLDL-P + Large HDL-P + VLDL size + HDL size + LP-IR score + Oxidized LDL + Lp-PLA2 activity +"  
[X Link](https://x.com/bryan_johnson/status/1986883069501178091)  2025-11-07T19:46Z 762.2K followers, 18.8M engagements


"What is your recommended playlist for a X gram magic mushroom journey"  
[X Link](https://x.com/bryan_johnson/status/1987181598375354501)  2025-11-08T15:33Z 762.1K followers, 1.5M engagements


"I understand mindset matters when taking X grams of magic mushrooms what intention do you suggest for me"  
[X Link](https://x.com/bryan_johnson/status/1987221646785257850)  2025-11-08T18:12Z 762.1K followers, 1M engagements


"Starts tmrw 9:30am pacific XXX g dry Psilocybe cubensis (B+ cultivar)"  
[X Link](https://x.com/bryan_johnson/status/1987342166205866444)  2025-11-09T02:11Z 762.1K followers, 1.7M engagements


"Will start around 10:15am. Last night I was asleep by X. Woke up X am. Feel fantastic. 10k lux in eyes. Some protein extra virgin olive oil and XX super molecules. Worked out. Finishing pre mushroom brain measurement with Kernel Flow"  
[X Link](https://x.com/bryan_johnson/status/1987578321912349043)  2025-11-09T17:49Z 762.1K followers, 2.9M engagements


"5g of magic mushrooms"  
[X Link](https://x.com/bryan_johnson/status/1987587885214859774)  2025-11-09T18:27Z 762.2K followers, 38.6M engagements


"Hey guys. Its Kate Tolo Bryans co-founder. Im taking over his X account today. Hes just taken the 5g of magic mushrooms. Ive officially confiscated his phone 🫡 Ill report back once he starts feeling it"  
[X Link](https://x.com/bryan_johnson/status/1987594468544192942)  2025-11-09T18:53Z 762.1K followers, 3.8M engagements


"UPDATE 1: Its around X hour since he took his 5g dose of magic mushrooms. Some of his observations so far: + loves the drums music hes listening to. Apparently he started learning this style of drums years ago + described the dose as calm and pleasant. Hes having a REALLY lovely time. + sense of time is definitely warped. He thinks more time has passed than it has. thinks he has peaked + he felt a strong desire to look after the people in the room checking if were ok. He asked me if I had eaten. We told him that were all good and that he can focus on himself and the experience + visual"  
[X Link](https://x.com/bryan_johnson/status/1987611878428995672)  2025-11-09T20:02Z 762.1K followers, 8.2M engagements


"UPDATE 2: He needed to pee. Upon returning he stared at this cup for XX mins. What does it mean"  
[X Link](https://x.com/bryan_johnson/status/1987624591402164524)  2025-11-09T20:53Z 762.1K followers, 4.6M engagements


"UPDATE 4: The best salad Ive ever eaten"  
[X Link](https://x.com/bryan_johnson/status/1987660578979209251)  2025-11-09T23:16Z 762.1K followers, 1.9M engagements


"Hey all Im just so happy to be alive"  
[X Link](https://x.com/bryan_johnson/status/1987696458024559048)  2025-11-10T01:38Z 762.2K followers, 2M engagements


"Also much love to all of you. It weirdly feels like my consciousness is deeply intertwined with yours. Feels like family. Youre assholes and terrible. Youre alsonah just mostly assholes and terrible. Still love you all anyways"  
[X Link](https://x.com/bryan_johnson/status/1987729994924322873)  2025-11-10T03:52Z 762.2K followers, 3.7M engagements


"Life feels fresh today. New thoughts are flowing. My mind feels more nimble and curious. Did my normal morning routine: light in eyes nutritious breakfast exercise sauna red light. Completed some tests: brain scan + blood samples. Now going to write"  
[X Link](https://x.com/bryan_johnson/status/1987947606887330008)  2025-11-10T18:16Z 762.1K followers, 649.3K engagements


"Ok here is my trip report from XXXX grams of magic mushrooms XXXX mg of psilocybin. The dose used in modern clinical trials. First the experience was exhilarating. Positive in every way. I felt like a kid finding and exploring a new playground. My sensory perception was dialed up to levels I must have felt as a kid but have been dulled with time. I experienced sense of touch with awe. Feeling my fingers rub together felt novel. Touching my skin and running my feet over the threaded quilt lit up my brain. It seemed that my mind was insatiably curious and wanted to deploy its sensors into the"  
[X Link](https://x.com/bryan_johnson/status/1988064701075648776)  2025-11-11T02:02Z 762.2K followers, 3M engagements


"I'm exploring magic mushrooms as a longevity therapy. Sunday was my first dose: XXXX grams of dried Psilocybe cubensis (B+ strain) containing XXXXX mg of psilocybin. Here is an overview of the current scientific evidence: Longevity Psilocybin extended lifespan in mice and preserved telomeres in human cells first evidence linking psychedelics to longevity. Inflammation A single psilocybin dose reduced TNF- CRP and IL-6. Systemic inflammation markers tied to aging. Neuroplasticity Psilocybin increases brain entropy breaks rigid patterns and boosts long term cognition and flexibility. Clinical"  
[X Link](https://x.com/bryan_johnson/status/1988282302389256295)  2025-11-11T16:26Z 762.2K followers, 443.2K engagements


"6/ Cognitive and neuroprotective benefits of psilocybin and similar psychedelics Some conceptual models suggest psilocybin may counteract neurodegeneration and Alzheimer's disease. This is attributed to its 5HT2A activation which is believed to increase neural plasticity reduce inflammation and enhance cognitive functions such as creativity cognitive flexibility and facial recognition. Additionally early in-vitro research has indicated that DMT a psychedelic with a mechanism comparable to psilocybin might protect human iPSC-derived neurons and microglia in cell culture from hypoxia. This"  
[X Link](https://x.com/bryan_johnson/status/1988282317295718688)  2025-11-11T16:26Z 762.2K followers, 105.9K engagements


"This study is not robust enough to show causation and theres plenty of evidence showing alcohol is correlated with worse academic performance lower earnings and serious health risks"  
[X Link](https://x.com/bryan_johnson/status/1988387733187031094)  2025-11-11T23:25Z 762.2K followers, 268.6K engagements


"Im in D.C. for a thing. Packing my longevity for travel is a lot. A pair of underwear and toothbrush would be so much easier. Sometimes I think youre right and this whole thing has gotten out of control and I need to chill"  
[X Link](https://x.com/bryan_johnson/status/1988621418800509387)  2025-11-12T14:54Z 762.2K followers, 3.5M engagements


"the shrooms told me that we need to get our shit together. that humanity is a bundle of bad habits. im headed back in a few weeks and they need a response from us. what do i tell them"  
[X Link](https://x.com/bryan_johnson/status/1988731709177884917)  2025-11-12T22:12Z 762.1K followers, 820.3K engagements


"Im playing with this post making fun of myself for the insane lengths I go to embody this dont die experiment. Given that people are interested in my mindset post mushrooms and may be unfamiliar with my humor this post is play and not serious"  
[X Link](https://x.com/bryan_johnson/status/1988973576633085972)  2025-11-13T14:13Z 762.1K followers, 96.1K engagements


"give your best advice to someone struggling in a rough patch of life"  
[X Link](https://x.com/bryan_johnson/status/1988998687549268470)  2025-11-13T15:53Z 762.2K followers, 3.5M engagements


"When ppl want something they can't have they create moral frameworks for why they never really wanted it anyways (i.e. body positivity). There will be GLP-1 equivalents for anti-aging. Humanity will then clamor for Don't Die and delete remembrance that we ever defended death"  
[X Link](https://x.com/bryan_johnson/status/1989343773462270289)  2025-11-14T14:44Z 762.1K followers, 651.8K engagements


"2/ How sauna heat temporarily damaged my sperm in two waves and why Sauna without ice protection on the boys hit my fertility in two waves. First immediate followed by partial recovery and then another dip before full recovery occurred. The recovery then led to all-time high fertility markers. Immediate After X weeks without icing my motility and total motile count dropped sharply while total sperm count stayed the same. This reflects heat damaging the mature sperm already stored in the epididymis where they sit for about two weeks before ejaculation. X weeks post re-icing: second wave of"  
[X Link](https://x.com/bryan_johnson/status/1989381734560149966)  2025-11-14T17:15Z 762.2K followers, 56.8K engagements


"3/ Men ice your balls when you go into sauna Here is my icing protocol + ice the boys during sauna + use a non-toxic reusable ice pack material + wear cotton boxers and shorts + place ice packs in-between boxers/shorts + keep in place for the entire session"  
[X Link](https://x.com/bryan_johnson/status/1989381736699244554)  2025-11-14T17:15Z 762.1K followers, 53.1K engagements


"weekly protocol update: + completed tests post 5g 🍄 (25 mg psilocybin): + XXX blood biomarkers + 4x urine samples for hormone analysis + X kernel brain scans + X methylomic tests + 24/7 blood glucose monitoring + first brain scan results reported out analyzing + traveled to D.C. slept terribly in hotel + I love my morning routine so much"  
[X Link](https://x.com/bryan_johnson/status/1989471173693116694)  2025-11-14T23:11Z 761.6K followers, 239.3K engagements


"people use to ridicule me for clicks and now theyre trying to make money off my credibility"  
[X Link](https://x.com/bryan_johnson/status/1989739485148610970)  2025-11-15T16:57Z 762.1K followers, 214.5K engagements


"I'm going to seed something with you right now so you have time to sit with it. Next week I'm going to ask you to go sugar-free for the holidays. Eat all the berries you want. No added sugar. From Nov 21st through Jan 2nd"  
[X Link](https://x.com/bryan_johnson/status/1989767524293251099)  2025-11-15T18:48Z 762.1K followers, 757.5K engagements


"First mushroom trip data is out: my brain activity. Dose: X g dried Psilocybe cubensis (B+ strain) Containing XXXX mg psilocybin Psilocybin longevity experiment. What we see in the brain: + brain activity data mirror my subjective experience + strong decrease in my brains control center (prefrontal + premotor cortex) + strong increase in sensory auditory and speech integration + higher entropic brain patterns: open flexible less predictable exploratory + brain network patterns resembling a youthful state vs aged and rigid Matching what I reported experiencing: + felt like my consciousness was"  
[X Link](https://x.com/bryan_johnson/status/1989794845557493932)  2025-11-15T20:37Z 762.2K followers, 2.2M engagements


"@flowersslop nobody wants to die right now. people imagine they'll want to die in the future. it's an illusion. when that future arrives they still don't want to die. one more sunrise. one more i love you. one more breadth"  
[X Link](https://x.com/bryan_johnson/status/1989842822435147926)  2025-11-15T23:47Z 762.1K followers, 46.7K engagements


""set" and "setting" profoundly influence psychedelic experience. I propose a third pillar: bodyset. Health biomarkers meaningfully influence how the brain mind and body receives and processes psychedelics. Heres the idea: psychedelics dont land on a blank canvas. They interact with the autonomic nervous system inflammatory load metabolic stability sleep quality hormonal environment and overall physiological resilience of the person taking them. These internal conditions may tilt an experience toward insight and bliss or toward anxiety and dysregulation. If this is accurate then biomarkers"  
[X Link](https://x.com/bryan_johnson/status/1990131713562058804)  2025-11-16T18:55Z 762.1K followers, 138.5K engagements


"i have some more data to report out from the mushroom trip. but it's sensitive data. and I don't want anyone who's not interested in this to have to see it. so if you want to know scroll down. respect others and do not repost it or talk about it in the comments. . . . . . . . . . . . . . . . . . . . i'm trusting you to be responsible. . . . . . . . . . . . . . . . . . we are citizens of an online community. . . . . . . . . . . . . . . . . . . we must build bonds of trust with each other. . . . . . . . . . . . . . . . . . and some people just don't want to know about this stuff . . . . . . . ."  
[X Link](https://x.com/bryan_johnson/status/1990141346523603152)  2025-11-16T19:34Z 762.1K followers, 956.7K engagements


"What I'm eating today"  
[X Link](https://x.com/bryan_johnson/status/1990505938969894988)  2025-11-17T19:42Z 762.2K followers, 671.8K engagements


"my daily macros 2250 calories Protein: XXX grams (25%) Carbs: XXX grams (35%) Fat: XXX grams (40%) 130g of protein daily from flax pea hemp legumes (lentils peas beans) vegetables collagen peptides nuts and seeds. My protein intake is XXX g/kg of body weight"  
[X Link](https://x.com/bryan_johnson/status/1990508218075000963)  2025-11-17T19:51Z 762.1K followers, 165.2K engagements


"Health is now high status"  
[X Link](https://x.com/bryan_johnson/status/1990559626648338908)  2025-11-17T23:16Z 762.1K followers, 910.8K engagements


"@Bankless I liked how @RyanSAdams entered the conversation skeptical and confused and then worked through Don't Die with me and @TrustlessState was more familiar with the ideas and wanted to explore the outer edges"  
[X Link](https://x.com/bryan_johnson/status/1990884257665789990)  2025-11-18T20:46Z 761.6K followers, 14.5K engagements


"last week i seeded an idea: no sugar from nov XX jan X. an experiment in agency: either you run your impulses or your impulses run you. give it some thought.I'll be ask to see who's in"  
[X Link](https://x.com/bryan_johnson/status/1990889257175544070)  2025-11-18T21:06Z 762.2K followers, 183.2K engagements


"you'd feast on these goodies: blueberries blackberries raspberries strawberries cherries apples pears kiwi and pomegranate"  
[X Link](https://x.com/bryan_johnson/status/1990890967256236456)  2025-11-18T21:12Z 762.1K followers, 95.4K engagements


"im XX but in many ways my body runs like an XX yr old. sleep nutrition exercise + eliminating bad habits is the 80/20. if youre in a good place keep it up. if youre struggling take the first step; its always the hardest and always worth it. my biomarkers + muscle: 98th percentile (all men) + fat: 98th percentile optimal (all men) + bone mineral density: 99th percentile (all ages) + resting heart rate: elite athlete level + fertility: top 99th percentile (all men) + sexual function (NTE) 99th percentile (all men) + blood pressure lower than XX% of XX years old + vascular function: late teen /"  
[X Link](https://x.com/bryan_johnson/status/1991580927173251517)  2025-11-20T18:54Z 762.2K followers, 283.1K engagements


"off to sleep now. love the feeling of having given the day your all. knowing tomorrow morning is all fresh and new. hope you had a great day and sleep well"  
[X Link](https://x.com/bryan_johnson/status/1991718451044577492)  2025-11-21T04:00Z 762.1K followers, 100.4K engagements


"ok you've had a week to think about it. who's in no sugar nov XX - jan X eat all you want: blueberries blackberries raspberries strawberries cherries apples kiwi pomegranate etc. avoid cookies pies cakes sweet drinks chocolates cocktails anything with added sugar. on the other side you will be able to say: + I have agency + I am no longer controlled by urges + I am more emotionally stable + I feel more self-confident + I feel more energetic if you commit you also commit to report back in on jan 2nd to share how you did"  
[X Link](https://x.com/bryan_johnson/status/1991915123796246896)  2025-11-21T17:02Z 762.2K followers, 1.3M engagements


"Theres an argument that GLP-1s are playing a critical role in society not just for weight loss but as a technology of imagination. Something humans are in desperate need of as we try to reconcile with AI becoming the new fabric of society. GLP-1s expand human imagination by breaking psychological ceilings. Important because AI expands human capability without necessarily expanding self belief. The future requires us to imagine new versions of ourselves and GLP-1s show humans how a simple injection remaps what they can aspire to become. Most people live with a fixed self-model. Something like"  
[X Link](https://x.com/bryan_johnson/status/1991939679755882948)  2025-11-21T18:40Z 762.2K followers, 168.6K engagements


"This is my sleep from last night: + asleep X min + no wake events + no sleep stress + X hr XX min restorative sleep Waking up to this is a euphoric feeling. I want to convince you to also build your life around sleep. First let's consider what happens in the body on a night's sleep like this: Cleaning the brain: during early night deep sleep glial cells shrink by up to 60%. This creates tunnels for cerebrospinal fluid to power wash the brain clearing neurotoxins including -amyloid tau synuclein lactate and oxidized metabolites at X to 4x daytime rates. Every wake event stops the cleaning"  
[X Link](https://x.com/bryan_johnson/status/1992328219304079799)  2025-11-22T20:23Z 762.2K followers, 419.2K engagements


"More data from the mushroom trip. Psilocybin produced a large expected cortisol rise at peak effect. Clinical studies show a 100-300% surge in cortisol between 90-120 min after dosing. My data followed the same shape: low baseline sharp mid-day peak full evening normalization. Cortisol is a stress hormone but it's also part of normal circadian biology. My increase wasnt harmful stress. It was the cortisol response that psilocybin produces in controlled studies. This data confirms: + I had a normal adrenal reaction to psilocybin + a fast system reset (healthy HPA function)+ + no prolonged"  
[X Link](https://x.com/bryan_johnson/status/1992342383250509829)  2025-11-22T21:20Z 762.2K followers, 204.1K engagements


"The best anti-aging protocol is the avoidance of harm"  
[X Link](https://x.com/bryan_johnson/status/1992810090005758083)  2025-11-24T04:18Z 762.2K followers, 181.3K engagements


"Self destructive behavior is our species' Achilles' heel. We are the only species that actively engineers its own demise. We can overcome this. It's necessary for our survival. My self destructive behaviors are at an all-time low. I just don't do things anymore that unnecessarily cause me to die. It took years to get here. Occasionally my mind still suggests a debaucherous act but its quickly shot down. The math doesn't work. The aftermath is misery. I'm hopeful about the future because culture is shifting. Health is becoming high status. It a useful and powerful currency. Health isn't just"  
[X Link](https://x.com/bryan_johnson/status/1993098172760309859)  2025-11-24T23:23Z 762.2K followers, 158.2K engagements


"A new study shows low dose GLP-1RA reverses functional and molecular signs of aging in mice. Decoupled from body weight and food intake data suggests they may be potent rejuvenation agents that reverse biological aging via the brain. 🧵"  
[X Link](https://x.com/bryan_johnson/status/1993114585617121544)  2025-11-25T00:28Z 762.2K followers, 167.6K engagements


"If you have a secret enemy. Heres how you sabotage them this Thanksgiving. Adjust what you say to their personal situation. Mark what are you doing this Thanksgiving I hope you get some real downtime. Youve been grinding nonstop. Your cortisol must be through the roof. Honestly you look like you could use a break. Cortisol is the silent killer they say. You could really use a hard reset. Thanksgiving is perfect for that. I read this study about social connection and letting go is more important for health than strict adherence. Its like signaling safety to your body. Thats what Im doing. A"  
[X Link](https://x.com/bryan_johnson/status/1993408391822426236)  2025-11-25T19:56Z 762.2K followers, 172.7K engagements


"what i'm eating today longevity score (1-10) gemini: XX gpt: XXX grok: XXX claude: 9"  
[X Link](https://x.com/bryan_johnson/status/1993767973723746412)  2025-11-26T19:45Z 762.1K followers, 232K engagements


"Ave thanksgiving meal is = to smoking X cigarettes. Why and how to avoid. Average + 4500 calories across day + XXX g fat + XX g saturated fat + 450600 g carbs + 150200 g sugar (pies rolls alcohol.) + 30004500 mg sodium The damage: + massive glucose spikes + insulin surge + crash then hunger rebound + acute endothelial dysfunction + oxidative stress + immune suppression + sleep disruption Roughly equal in metabolic injury as X cigarettes. How to eat + start meal with small amount of nuts: macadamia nuts walnuts hazelnuts almonds + roasted vegetables + legumes (lentils beans edamame) + add"  
[X Link](https://x.com/bryan_johnson/status/1994126157344870423)  2025-11-27T19:28Z 762.2K followers, 4.9M engagements


"happy thanksgiving"  
[X Link](https://x.com/bryan_johnson/status/1994130189710971166)  2025-11-27T19:44Z 762.2K followers, 207.9K engagements


"@Helios_Movement optimal air + psychoactives + goth balance in all things"  
[X Link](https://x.com/bryan_johnson/status/1994151108659564932)  2025-11-27T21:07Z 762.2K followers, 540.2K engagements


"@DKThomp worth noting you morally inverted to equate indulgence with emotion love and connection and frame health as sterile cold anti-human. joy does not require indulgence and health does not eliminate joy"  
[X Link](https://x.com/bryan_johnson/status/1994298264439673050)  2025-11-28T06:52Z 761.8K followers, 167.7K engagements


"If you went all out yesterday and feel like shit today I invite you to go on a walk with me right now. See if you can break away from whatever you're doing or if you can't save this and read it later when you can be out walking. Evidence shows that walking and talking improves: + creativity + the ability to form new connections + emotional regulation + problem solving My goal in our conversation is to connect with you at a deeper level than an ephemeral social post would normally allow. Thus why I'm asking you to change your physical setting and actually go on a walk with me. Seriously.let's"  
[X Link](https://x.com/bryan_johnson/status/1994480770325647636)  2025-11-28T18:57Z 762.2K followers, 231.3K engagements


"Im taking magic mushrooms and livestreaming it on sunday. + X hours Live + 10am PST Sun 30th + XXXX g mushrooms dried + XX mg of active psilocybin + Strain B+ (psilocybin cubensis) + 2nd dose (3 total across X months) Were measuring XXX biomarkers to determine the effect on longevity. This is the most quantified psychedelic experiment in history. Guest appearances from: + @Grimezsz DJ'ing a Live set + @HamiltonMorris and @gjurvetson discuss psychedelics + @MrBeast @naval @Benioff @friedberg are being good friends and checking in on me during the experience Moderated by: goth girl @_katetolo"  
[X Link](https://x.com/bryan_johnson/status/1994518006421230083)  2025-11-28T21:25Z 762.2K followers, 2.6M engagements


"Friends do not try this at home. This stream is for observation only not medical advice legal advice or encouragement. The activity is in a legal setting with a professional facilitator and being medically supervised. Psilocybin is illegal in many places and carries real medical and psychological risks. Anyone considering it should only do so where lawful with proper clinical support and after consulting a qualified professional. This post is not a recommendation or an invitation to replicate these actions"  
[X Link](https://x.com/bryan_johnson/status/1994518750696268139)  2025-11-28T21:28Z 762.2K followers, 137.9K engagements


"Regarding dose people talk about a 'heroic dose' as X grams of dried mushrooms but that's a misleading metric. Weight alone tells you nothing about potency. Active psilocybin content can vary 25x between strains harvest conditions and even specific parts of the same harvest. In extreme cases X grams of one batch could have 20mg of psilocybin; X grams of another could approach 60mg+. Without a lab test you don't know what dose you're actually taking. My lab confirmed dose is XXXX grams containing XX mg of active psilocybin. In clinical settings a 'high dose' intended to induce mystical"  
[X Link](https://x.com/bryan_johnson/status/1994594791502614613)  2025-11-29T02:30Z 762.2K followers, 115.8K engagements


"Psychedelics don't land on a blank canvas. Your health meaningfully shapes how psychedelics land in the mind and body. Biomarkers such as stress load inflammation metabolic stability sleep hormones and autonomic balance can tilt the experience positive or negative"  
[X Link](https://x.com/bryan_johnson/status/1994826531248771556)  2025-11-29T17:51Z 762.1K followers, 113.1K engagements


"I'll leave it to mushrooms about what they want to say"  
[X Link](https://x.com/bryan_johnson/status/1994853676561961273)  2025-11-29T19:39Z 762.2K followers, 904.5K engagements


"@Polymarket probably goth girl"  
[X Link](https://x.com/bryan_johnson/status/1994882593502982584)  2025-11-29T21:34Z 762.2K followers, 129.9K engagements


"gathered the bryans to find out which one is responsible for committing to doing mushrooms on a livestream"  
[X Link](https://x.com/bryan_johnson/status/1994968360078250037)  2025-11-30T03:14Z 762.2K followers, 189.3K engagements


"see you on the other side"  
[X Link](https://x.com/bryan_johnson/status/1995181897991983311)  2025-11-30T17:23Z 762.2K followers, 313K engagements


"makes me so happy everyone had so much fun"  
[X Link](https://x.com/bryan_johnson/status/1995579612127264802)  2025-12-01T19:43Z 762.2K followers, 222.8K engagements


"power laws to hit peak performance this week + final meal X hr before sleep + screens off XX min before bed + read book XX min before bed + wake up light in eyes - 10k lux or sunlight + XX min exercise better sleep mood alertness energy appetite control stress control"  
[X Link](https://x.com/bryan_johnson/status/1995899641699991964)  2025-12-02T16:55Z 762.2K followers, 182K engagements


"i hope this type of love finds you in life"  
[X Link](https://x.com/bryan_johnson/status/1995976389254914158)  2025-12-02T22:00Z 762.2K followers, 2M engagements


"Hey just a note that I appreciate all the kindness. I've become so accustomed to constantly being body-checked that the contrast feels fresh. Sending warmth your way too"  
[X Link](https://x.com/bryan_johnson/status/1996252185714381164)  2025-12-03T16:16Z 762.2K followers, 550.6K engagements


"Tested XXX biomarkers today post dose #2 of mushrooms X weeks after 1st dose: X. Core safety: full blood counts kidney and liver enzymes electrolytes urinalysis. The basics that tell us if my biological systems are staying stable. X. Metabolism & cardiovascular risk: glucose and insulin advanced lipoproteins (NMR profile ApoB Lp(a)) oxidized LDL Lp-PLA2 NT-proBNP and more to see how a high-dose session interacts with long-term heart and metabolic health. X. Hormones & growth signals: testosterone (total + free) DHT thyroid panel DHEA-S IGF-1 leptin prolactin and others to understand how"  
[X Link](https://x.com/bryan_johnson/status/1996344674290925758)  2025-12-03T22:23Z 762.2K followers, 139.4K engagements


"Build this one life habit: final food X hr before sleep. Never ever break it. It will change your life I promise"  
[X Link](https://x.com/bryan_johnson/status/1996607045743874140)  2025-12-04T15:46Z 762.2K followers, 1.1M engagements


"bc lowers resting heart rate fall asleep after boosts melatonin aligns circadian rhythms drops core body temp for deeper sleep improved mood better NTEsmaking you a better human"  
[X Link](https://x.com/bryan_johnson/status/1996609290883547265)  2025-12-04T15:55Z 762.2K followers, 143.9K engagements


"unacceptable starting a new protocol to get this down to 18"  
[X Link](https://x.com/bryan_johnson/status/1996685770028134835)  2025-12-04T20:59Z 762.2K followers, 489.4K engagements


"@_alicewins it also happens to me"  
[X Link](https://x.com/bryan_johnson/status/1996727921499918633)  2025-12-04T23:46Z 762.1K followers, 27.6K engagements


"I reduced microplastics in my sperm by XX% and I think it was the dry sauna"  
[X Link](https://x.com/bryan_johnson/status/1997106076974829655)  2025-12-06T00:49Z 762.2K followers, 288.9K engagements


"Sauna is one of the most effective health protocols I've done. Here is everything I've learned; it's the most robust characterization ever produced. Results: 1) Fifteen sessions of sauna dramatically reduced environmental toxins in my body: + XX% drop in 24-D + XXX% drop in MEP + XX% drop in MBP + XXX% drop in MEHP (undetectable post sauna) + XX% drop in NAPR + XX% drop in HEMA + XXX% drop in Perchlorate (undetectable post sauna) X. Sauna eliminated XX% of microplastics from my ejaculate. Nov 2024: XXX particles/mL July 2025: XX particles/mL Nearly identical drop in my blood same time period:"  
[X Link](https://x.com/bryan_johnson/status/1997403290171330638)  2025-12-06T20:30Z 762.2K followers, 4.8M engagements


"The most destructive belief in the world is that sleep deprivation produces better results"  
[X Link](https://x.com/bryan_johnson/status/1997937051841462305)  2025-12-08T07:51Z 762.2K followers, 503.7K engagements


"I wonder if these tiny ones will reverse my age too suddenly you notice hundreds of tiny people dressed in cartoonish clothing marching across your tablecloth jumping into your bowl swimming around and clinging to your spoon as you lift it for another taste"  
[X Link](https://x.com/bryan_johnson/status/1998497764012077434)  2025-12-09T20:59Z 762.2K followers, 169.1K engagements


"what should I do for my third mushroom trip first one was documented w text/images. second was livestreamed. livestream again different format what do you think"  
[X Link](https://x.com/bryan_johnson/status/1998546387634631115)  2025-12-10T00:12Z 762.2K followers, 142.3K engagements


"regarding an outdoor setting there are legal limitations in the u.s. on where I can physically be. the physical space is approved and you cant be outside of it"  
[X Link](https://x.com/bryan_johnson/status/1998546829546500552)  2025-12-10T00:14Z 762.2K followers, 48.3K engagements


"Elon needs sleep. I take him at face value that his primary objective is the survival of the human race. In that pursuit his samurai virtue is clarity of mind and judgment. The birth of superintelligence demands unprecedented sobriety of thought and prescience. Sleep manufactures these abilities. Early 50s fragmented high-stress sleep chemically degrades cognitive clarity. Reliably eroding executive function risk evaluation and emotional regulation while leaving subjective high confidence intact. Impairment without awareness. The spectacular miracle of our existence and also its fragility"  
[X Link](https://x.com/bryan_johnson/status/1998616755716137195)  2025-12-10T04:52Z 762.2K followers, 96.2K engagements


"@nikitabier Dont Die"  
[X Link](https://x.com/bryan_johnson/status/1998649288302424558)  2025-12-10T07:01Z 762.2K followers, 121.5K engagements