#  @NatureCellBio Nature Cell Biology Nature Cell Biology posts on X about cell, study, article, stem the most. They currently have [-------] followers and [---] posts still getting attention that total [-----] engagements in the last [--] hours. ### Engagements: [-----] [#](/creator/twitter::111305843/interactions)  - [--] Week [-----] -73% - [--] Month [-------] +614% - [--] Months [-------] +2,345% - [--] Year [---------] +31% ### Mentions: [--] [#](/creator/twitter::111305843/posts_active)  - [--] Week [--] +33% - [--] Month [--] +13% - [--] Months [--] +340% - [--] Year [--] -30% ### Followers: [-------] [#](/creator/twitter::111305843/followers)  - [--] Month [-------] -0.16% - [--] Months [-------] -1.40% - [--] Year [-------] -1.40% ### CreatorRank: undefined [#](/creator/twitter::111305843/influencer_rank)  ### Social Influence **Social category influence** [technology brands](/list/technology-brands) [currencies](/list/currencies) [finance](/list/finance) [ncaa basketball](/list/ncaa-basketball) [nfts](/list/nfts) [cryptocurrencies](/list/cryptocurrencies) [travel destinations](/list/travel-destinations) **Social topic influence** [cell](/topic/cell), [study](/topic/study), [article](/topic/article), [stem](/topic/stem), [in the](/topic/in-the), [membrane](/topic/membrane), [mitosis](/topic/mitosis), [human](/topic/human), [vivo](/topic/vivo), [growth](/topic/growth) **Top accounts mentioned or mentioned by** [@zakbakes](/creator/undefined) [@pagliarinilab](/creator/undefined) [@sloanlab](/creator/undefined) [@caitlinsojka](/creator/undefined) [@brumbaughjb](/creator/undefined) [@jingtaoguo](/creator/undefined) [@leqianyu](/creator/undefined) [@szmydradoslaw](/creator/undefined) [@thecesarelab](/creator/undefined) [@radoncdocgee](/creator/undefined) [@scientistjoanna](/creator/undefined) [@ruggerodavide](/creator/undefined) [@natcellbionaturecom](/creator/undefined) [@demetriadeslab](/creator/undefined) [@cuilabchem](/creator/undefined) [@stanforduchem](/creator/undefined) [@stanfordchemh](/creator/undefined) [@bianxiaoc](/creator/undefined) [@eddagschulz](/creator/undefined) [@filipovskalab](/creator/undefined) **Top assets mentioned** [Enzyme (MLN)](/topic/enzyme) [Luminal Universe (luminal-universe)](/topic/#luminal) [Flux (FLUX)](/topic/flux) [Synapse (SYN)](/topic/synapse) ### Top Social Posts Top posts by engagements in the last [--] hours "Ectosomes step forward in -synuclein spread Nature Cell Biology Glucosylceramide accumulation — a hallmark of GBA1- and LRRK2-linked Parkinson’s disease — drives ectosome shedding from neurons. A study now shows that these plasma membrane-derived vesicles shuttle pathogenic α-synuclein across cells revealing ectosomes as an underappreciated route of pathology propagation in Parkinson’s disease" [X Link](https://www.nature.com/articles/s41556-026-01870-7) 2026-02-14T17:20Z 122.8K followers, [----] engagements "Ex vivo imaging reveals the spatiotemporal control of ovulation Nature Cell Biology Thomas Marx et al. devise a live imaging approach to spatiotemporally dissect mouse ovulation ex vivo" [X Link](https://www.nature.com/articles/s41556-024-01524-6) 2024-12-04T15:00Z 2.1M followers, 163.3K engagements "Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling Nature Cell Biology Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation leading to YAP/TAZ activation" [X Link](https://www.nature.com/articles/s41556-025-01773-z) 2026-01-24T13:14Z 2.1M followers, [----] engagements "💫NEW: Visvader Lindeman & co identify #luminal progenitors as likely cells-of-origin in #BRCA2-#BreastCancer exhibiting dysregulated #proteostasis and translation which may be therapeutically targeted via mTORC1 inhibition. https://www.nature.com/articles/s41556-023-01315-5 https://rdcu.be/dvVAa https://www.nature.com/articles/s41556-023-01315-5 https://rdcu.be/dvVAa" [X Link](https://x.com/NatureCellBio/status/1746282463205228812) 2024-01-13T21:25Z 122.8K followers, 14.7K engagements "Triacylglycerol mobilization underpins mitochondrial stress recovery Nature Cell Biology Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis" [X Link](https://www.nature.com/articles/s41556-024-01586-6) 2025-02-17T14:48Z 2.1M followers, [----] engagements "Nuclear speckles regulate functional programs in cancer Nature Cell Biology This study reports that nuclear speckle constituents have two expression states in cancer correlating with patient survival and HIF-2α functional programs. HIF-2α mediates nuclear speckle association of key genes activated in renal cancer" [X Link](https://www.nature.com/articles/s41556-024-01570-0) 2025-01-13T13:38Z 2.1M followers, [----] engagements "The transcription factor GABPA is a master regulator of naive pluripotency Nature Cell Biology Zhang and colleagues identify the transcription factor GABPA as a regulator of zygotic genome activation epiblast formation and naive pluripotency establishment" [X Link](https://www.nature.com/articles/s41556-024-01554-0) 2025-01-10T12:56Z 2.1M followers, [----] engagements "Precursor occupancy controls mitochondrial import channel via proteolysis Nature Cell Biology Blocking the translocase of the outer membrane (TOM) channel induces elimination of unoccupied protein import channels in the inner membrane by an ATP-dependent protease. Precursor-dependent adjustment of the number of translocator channels provides new insights into mitochondrial quality control upon protein import stress" [X Link](https://www.nature.com/articles/s41556-024-01575-9) 2025-02-16T18:53Z 2.1M followers, [----] engagements "AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress Nature Cell Biology Zhai Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during tumour growth" [X Link](https://www.nature.com/articles/s41556-024-01549-x) 2025-01-31T13:27Z 2.1M followers, [----] engagements "Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations Nature Cell Biology Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaining a robust redox ratio is key to clonal prevalence" [X Link](https://www.nature.com/articles/s41556-024-01574-w) 2025-02-16T18:41Z 2.1M followers, [----] engagements "H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium Nature Cell Biology Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment whereas its suppression which is also observed upon injury induces a plastic state and expression of genes involved in regeneration" [X Link](https://www.nature.com/articles/s41556-024-01580-y) 2025-02-19T21:35Z 2.1M followers, [----] engagements "A nucleolar mechanism suppresses organismal proteostasis by modulating TGF/ERK signalling Nature Cell Biology Zhu et al. show that disabling the nucleolar FIB-1NOL-56 complex protects Caenorhabditis elegans from the toxicity of neurodegeneration-linked protein aggregates across tissues by modulating TGFβ signalling and enhancing proteasome activity" [X Link](https://www.nature.com/articles/s41556-024-01564-y) 2025-02-16T18:38Z 2.1M followers, [----] engagements "Speckle signatures dictate cancer prognosis Nature Cell Biology Nuclear speckles are dynamic structures enriched in RNA and RNA regulators with varying compositions. A study now reports two distinct signatures of nuclear speckles that are linked to the prognosis of clear cell renal cell carcinoma. The signatures influence the expression of genes regulated by the transcription factor HIF2α" [X Link](https://www.nature.com/articles/s41556-024-01569-7) 2025-01-13T13:38Z 2.1M followers, [----] engagements "Mitochondrial YME1L1 governs unoccupied protein translocase channels Nature Cell Biology Hsu et al. show that mitochondrial import blockage stress activates the ATP-dependent protease YME1L1 which degrades mitochondrial presequence translocase TIM23 subunits to promote cell growth" [X Link](https://www.nature.com/articles/s41556-024-01571-z) 2025-02-16T18:53Z 2.1M followers, [----] engagements "Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma Nature Cell Biology Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with aberrant development in glioblastoma" [X Link](https://www.nature.com/articles/s41556-024-01583-9) 2025-02-19T21:31Z 2.1M followers, [----] engagements "Misshapen chromosomes in check by mechanics Nature Cell Biology Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies" [X Link](https://www.nature.com/articles/s41556-024-01573-x) 2025-02-17T13:55Z 2.1M followers, [----] engagements "Innate immune sensing of cell death in disease and therapeutics Nature Cell Biology Man and Kanneganti discuss how pattern-recognition sensors in innate immune cells recognize and respond to cell-death signatures and highlight molecular targets for potential therapeutic development" [X Link](https://www.nature.com/articles/s41556-024-01491-y) 2024-12-23T17:01Z 2.1M followers, [----] engagements "Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint Nature Cell Biology Hervé Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension" [X Link](https://www.nature.com/articles/s41556-024-01565-x) 2025-02-17T13:55Z 2.1M followers, [----] engagements "Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts Nature Cell Biology Luo et al. show in zebrafish and mouse that upon intrahepatic biliary duct damage gallbladder smooth muscle cells migrate to the common hepatic duct where they produce retinoic acid to promote regeneration of the intrahepatic biliary duct" [X Link](https://www.nature.com/articles/s41556-024-01568-8) 2025-02-17T13:51Z 2.1M followers, [----] engagements "Multiomics reveals that triacylglycerol mobilization helps drive recovery from mitochondrial stress Nature Cell Biology We devised a multiomics strategy to identify metabolic pathways used by yeast to surmount mitochondrial stress. Strains capable of recovery relied on triacylglycerol mobilization to provide acyl groups for nascent cardiolipin biosynthesis during mitochondrial biogenesis. We further linked multiple proteins to this mobilization phenotype including essential lipases in both yeast and mammalian model systems" [X Link](https://www.nature.com/articles/s41556-024-01603-8) 2025-02-17T14:48Z 2.1M followers, [----] engagements "The enhancer module of Integrator controls cell identity and early neural fate commitment Nature Cell Biology Zhang et al. report that INST10 part of the Integrator enhancer module promotes epigenetic changes and transcription factor binding at enhancers that drive neural cell fate commitment by stabilizing SOX2 binding at chromatin upon pluripotency exit" [X Link](https://www.nature.com/articles/s41556-024-01556-y) 2024-12-15T23:54Z 2.1M followers, [----] engagements "Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity Nature Cell Biology Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane thereby regulating body temperature glucose homeostasis and body weight in obese mice" [X Link](https://www.nature.com/articles/s41556-024-01555-z) 2025-01-31T13:39Z 2.1M followers, [----] engagements "Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy Nature Cell Biology Licheva Pflaum Babic Mancilla et al. show that low-affinity cargoreceptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation" [X Link](https://www.nature.com/articles/s41556-024-01572-y) 2025-01-07T12:49Z 2.1M followers, [----] engagements "TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling Nature Cell Biology Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair chromosomal instability and whole-genome doubling with distinct mechanisms" [X Link](https://www.nature.com/articles/s41556-024-01558-w) 2025-01-01T19:26Z 2.1M followers, [----] engagements "Mitochondria and cell death Nature Cell Biology Several processes of regulated cell death engage or use mitochondria which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial outer membrane permeabilization" [X Link](https://www.nature.com/articles/s41556-024-01429-4) 2024-12-29T18:50Z 2.1M followers, 17.3K engagements "💫NEW: @Gardinilab & co show that INST10 (Integrator subunit) promotes #epigenetic changes and transcription factor binding at enhancers driving #neural fate by stabilizing SOX2 binding at #chromatin upon #pluripotency exit. https://www.nature.com/articles/s41556-024-01556-y https://rdcu.be/d3EWd https://www.nature.com/articles/s41556-024-01556-y https://rdcu.be/d3EWd" [X Link](https://x.com/NatureCellBio/status/1868444541101195584) 2024-12-15T23:54Z 122.8K followers, [----] engagements "☕In this year's #CellDeath focus: Man & Kanneganti reviewed how pattern-recognition sensors in #ImmuneCells recognize and respond to cell-death signatures & highlighted molecular targets for potential therapeutic development. https://www.nature.com/articles/s41556-024-01491-y https://rdcu.be/d4uDO https://www.nature.com/articles/s41556-024-01491-y https://rdcu.be/d4uDO" [X Link](https://x.com/NatureCellBio/status/1871239603149258970) 2024-12-23T17:01Z 122.8K followers, [----] engagements "☕This year in our #CellDeath focus: Kaiwen W. Chen & Petr Broz reviewed recent work highlighting the regulation of gasdermins and emerging biological roles including in non-lethal pore formation and host defence. #pyroptosis https://www.nature.com/articles/s41556-024-01474-z https://rdcu.be/d4BME https://www.nature.com/articles/s41556-024-01474-z https://rdcu.be/d4BME" [X Link](https://x.com/NatureCellBio/status/1873101360721457439) 2024-12-28T20:18Z 122.8K followers, [----] engagements "☕This year in our #CellDeath focus: Glover Schreiner Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis https://www.nature.com/articles/s41556-024-01429-4 https://rdcu.be/d46gt https://www.nature.com/articles/s41556-024-01429-4 https://rdcu.be/d46gt" [X Link](https://x.com/NatureCellBio/status/1873441374537949204) 2024-12-29T18:50Z 122.8K followers, 17.3K engagements "☕This year in our #CellDeath focus: Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis which could be exploited to treat #cancer. https://www.nature.com/articles/s41556-024-01425-8 https://rdcu.be/d493Q https://www.nature.com/articles/s41556-024-01425-8 https://rdcu.be/d493Q" [X Link](https://x.com/NatureCellBio/status/1873816020659638339) 2024-12-30T19:38Z 122.8K followers, [----] engagements "☕This year Granath-Panelo and Kajimura reviewed evidence of #mitochondria heterogeneity in different contexts and discussed how mitochondrial malleability contributes to cell fate determination and tissue remodeling. https://www.nature.com/articles/s41556-024-01410-1 https://rdcu.be/d5gHT https://www.nature.com/articles/s41556-024-01410-1 https://rdcu.be/d5gHT" [X Link](https://x.com/NatureCellBio/status/1874121672665817306) 2024-12-31T15:53Z 122.8K followers, [----] engagements "💫NEW by @Wtlu3 @CharlesSwanton @nnennayaKanu @bartek_Lab & co: analyses of data from the TRACERx cohort of #LungCancer patients delineate how FAT1 regulates HR repair chromosomal instability & whole-genome doubling with distinct mechanisms. @thecrick https://www.nature.com/articles/s41556-024-01558-w https://www.nature.com/articles/s41556-024-01558-w" [X Link](https://x.com/NatureCellBio/status/1874537614566678963) 2025-01-01T19:26Z 122.8K followers, [----] engagements "💫NEW: Zhang & co identify the transcription factor GABPA as a regulator of #ZygoticGenomeActivation #epiblast formation and naive #pluripotency establishment. https://www.nature.com/articles/s41556-024-01554-0 https://www.nature.com/articles/s41556-024-01554-0" [X Link](https://x.com/NatureCellBio/status/1877701123114418437) 2025-01-10T12:56Z 122.8K followers, [----] engagements "💫NEW by @berger_lab & co: #NuclearSpeckle (NS) constituents have [--] expression states in #cancer correlating with patient survival & HIF-2 functional programs. HIF-2 mediates NS association of key genes activated in renal cancer. https://www.nature.com/articles/s41556-024-01570-0 https://rdcu.be/d56c7 https://www.nature.com/articles/s41556-024-01570-0 https://rdcu.be/d56c7" [X Link](https://x.com/NatureCellBio/status/1878798739806298297) 2025-01-13T13:38Z 122.8K followers, [----] engagements "🧁Interested in reading more about the study Here's the N&Vs article written by Hiro Takakuwa & Tetsuro Hirose. https://www.nature.com/articles/s41556-024-01569-7 https://rdcu.be/d56d1 https://www.nature.com/articles/s41556-024-01569-7 https://rdcu.be/d56d1" [X Link](https://x.com/NatureCellBio/status/1878798742234738986) 2025-01-13T13:38Z 122.8K followers, [----] engagements "👋🏿Happy new year and our first [----] issue's out Cover: #chromosomal instability in #cancer 👉Review on #TranscriptionFactors and #cell quiescence 🔬#heterochromatin #embryo #DNArepair #pluripotency #proteostasis #obesity #CellCycle #CellDeath & more https://www.nature.com/ncb/volumes/27/issues/1 https://www.nature.com/ncb/volumes/27/issues/1" [X Link](https://x.com/NatureCellBio/status/1880246948348981529) 2025-01-17T13:33Z 122.8K followers, 13.1K engagements "💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth. https://www.nature.com/articles/s41556-024-01549-x https://rdcu.be/d8apH https://www.nature.com/articles/s41556-024-01549-x https://rdcu.be/d8apH" [X Link](https://x.com/NatureCellBio/status/1885318951812444558) 2025-01-31T13:27Z 122.8K followers, [----] engagements "💫NEW by @puigserver_lab & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane regulating body temperature glucose homeostasis and body weight in #obese mice. https://www.nature.com/articles/s41556-024-01555-z https://rdcu.be/d8atv https://www.nature.com/articles/s41556-024-01555-z https://rdcu.be/d8atv" [X Link](https://x.com/NatureCellBio/status/1885322073637024245) 2025-01-31T13:39Z 122.8K followers, [----] engagements "👋Our February issue's out Cover: #glioblastoma 👉🏼Review on #mitochondria #ProteinImport 👉🏻Viewpoint on #LipidMetabolism 🔬 #HumanEmbryos #NuclearSpeckles #PhaseSeparation #autophagy #mitosis #pluripotency #hematopoiesis #LipidDroplets & more https://www.nature.com/ncb/volumes/27/issues/2 https://www.nature.com/ncb/volumes/27/issues/2" [X Link](https://x.com/NatureCellBio/status/1890397917485109499) 2025-02-14T13:49Z 122.8K followers, [----] engagements "💫NEW: Zhu et al. show that disabling the nucleolar FIB-1NOL-56 complex protects C. elegans from neurodegeneration-linked protein aggregate TOXOCITY across tissues by modulating TGF signaling and enhancing proteasome activity. https://www.nature.com/articles/s41556-024-01564-y https://rdcu.be/d959J https://www.nature.com/articles/s41556-024-01564-y https://rdcu.be/d959J" [X Link](https://x.com/NatureCellBio/status/1891195515980665182) 2025-02-16T18:38Z 122.8K followers, [----] engagements "💫NEW: @AnuHemalatha @valentatormenta @RachelPerryLab1 & co track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin and find that maintaining a robust redox ratio is key to clonal prevalence. https://www.nature.com/articles/s41556-024-01574-w https://www.nature.com/articles/s41556-024-01574-w" [X Link](https://x.com/NatureCellBio/status/1891196333207298159) 2025-02-16T18:41Z 122.8K followers, [----] engagements "💫NEW: @KraftLabFR @WilflingLab & co show that low-affinity cargoreceptor interactions promote #autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation. https://www.nature.com/articles/s41556-024-01572-y https://www.nature.com/articles/s41556-024-01572-y" [X Link](https://x.com/NatureCellBio/status/1891197974010642919) 2025-02-16T18:48Z 122.8K followers, [----] engagements "💫NEW: Hsu et al. show that #mitochondria import blockage stress activates the ATP-dependent protease YME1L1 which degrades mitochondrial presequence translocase TIM23 subunits to promote cell growth. https://www.nature.com/articles/s41556-024-01571-z https://rdcu.be/d96cS https://www.nature.com/articles/s41556-024-01571-z https://rdcu.be/d96cS" [X Link](https://x.com/NatureCellBio/status/1891199152232542251) 2025-02-16T18:53Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here's the Research Briefing https://www.nature.com/articles/s41556-024-01575-9 https://rdcu.be/d96dg https://www.nature.com/articles/s41556-024-01575-9 https://rdcu.be/d96dg" [X Link](https://x.com/NatureCellBio/status/1891199154195464228) 2025-02-16T18:53Z 122.8K followers, [----] engagements "💫NEW: Luo & co show in zebrafish and mouse that upon intrahepatic biliary duct damage gallbladder smooth muscle cells migrate to the common hepatic duct where they promote regeneration of the intrahepatic biliary duct. https://www.nature.com/articles/s41556-024-01568-8 https://rdcu.be/eacNY https://www.nature.com/articles/s41556-024-01568-8 https://rdcu.be/eacNY" [X Link](https://x.com/NatureCellBio/status/1891485656540430643) 2025-02-17T13:51Z 122.8K followers, [----] engagements "💫NEW: Herv Scelfo et al. show that #chromosome missegregation induces #mTORC2 - & ATR-mediated p53 activation via a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension. https://www.nature.com/articles/s41556-024-01565-x https://www.nature.com/articles/s41556-024-01565-x" [X Link](https://x.com/anyuser/status/1891486715275067849) 2025-02-17T13:55Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here's the N&Vs article written by Joana C. Macedo Maria M. da Silva & Elsa Logarinho. https://www.nature.com/articles/s41556-024-01573-x https://rdcu.be/eacQv https://www.nature.com/articles/s41556-024-01573-x https://rdcu.be/eacQv" [X Link](https://x.com/anyuser/status/1891486717233782827) 2025-02-17T13:55Z 122.8K followers, [----] engagements "💫NEW: @Zak_Bakes @Pagliarini_Lab & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis. https://www.nature.com/articles/s41556-024-01586-6 https://www.nature.com/articles/s41556-024-01586-6" [X Link](https://x.com/anyuser/status/1891499937155657852) 2025-02-17T14:48Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here's the Research Briefing: https://www.nature.com/articles/s41556-024-01603-8 https://rdcu.be/eadgo https://www.nature.com/articles/s41556-024-01603-8 https://rdcu.be/eadgo" [X Link](https://x.com/anyuser/status/1891499939110261095) 2025-02-17T14:48Z 122.8K followers, [----] engagements "💫NEW: @Sloan_Lab @CaitlinSojka & co analyse the transcriptomic & epigenomic landscape of human #astrocyte maturation and identify an epigenetically regulated intermediate state linked with aberrant development in #glioblastoma. https://www.nature.com/articles/s41556-024-01583-9 https://rdcu.be/eayMF https://www.nature.com/articles/s41556-024-01583-9 https://rdcu.be/eayMF" [X Link](https://x.com/anyuser/status/1892326150992482540) 2025-02-19T21:31Z 122.8K followers, [----] engagements "💫NEW: @Brumbaugh_JB Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment whereas its suppression induces a plastic state and expression of genes involved in #regeneration. https://www.nature.com/articles/s41556-024-01580-y https://rdcu.be/eayN3 https://www.nature.com/articles/s41556-024-01580-y https://rdcu.be/eayN3" [X Link](https://x.com/anyuser/status/1892327203322372397) 2025-02-19T21:35Z 122.8K followers, [----] engagements "☕Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human #pluripotent stem cells by interacting with #NuclearMatrix protein Matrin-3 and regulating primed-specific genes. http://bit.ly/4kfVwT8 https://rdcu.be/ebq0W http://bit.ly/4kfVwT8 https://rdcu.be/ebq0W" [X Link](https://x.com/anyuser/status/1894857935995412809) 2025-02-26T21:11Z 122.8K followers, [----] engagements "☕Fulcher et al. show that #MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction triggering G1 arrest following delays in #mitosis associated with chromosome instability and #aneuploidy. https://bit.ly/3EUEc66 https://bit.ly/3EUEc66" [X Link](https://x.com/anyuser/status/1894859183121670213) 2025-02-26T21:16Z 122.8K followers, [----] engagements "☕@JingtaoGuo @LeqianYu & co characterize an intact Carnegie stage [--] #HumanEmbryo at single-cell resolution in a spatially resolved manner. https://bit.ly/3XhKW48 https://rdcu.be/ebq3Q https://bit.ly/3XhKW48 https://rdcu.be/ebq3Q" [X Link](https://x.com/anyuser/status/1894861130314448932) 2025-02-26T21:24Z 122.8K followers, [----] engagements "☕@szmyd_radoslaw @TheCesareLab @RadOncDoc_Gee & co: #DNArepair pathways impact if cells with DNA lesions arrest in mitosis. Homologous recombination-driven double Holliday junction formation elicits mitotic #CellDeath & suppresses inflammatory signaling. https://bit.ly/4bfssHr https://bit.ly/4bfssHr" [X Link](https://x.com/anyuser/status/1894863874484285866) 2025-02-26T21:35Z 122.8K followers, [----] engagements "🍰Read also the N&Vs article. https://bit.ly/4bk4ScD https://rdcu.be/ebq9N https://bit.ly/4bk4ScD https://rdcu.be/ebq9N" [X Link](https://x.com/anyuser/status/1894863876816019909) 2025-02-26T21:35Z 122.8K followers, [----] engagements "☕Interested in how cells respond to #mitochondria #ProteinImport stress Read our Review article by Nikolaus Pfanner Fabian den Brave & Thomas Becker. https://bit.ly/41oGhyD https://rdcu.be/ecb3x https://bit.ly/41oGhyD https://rdcu.be/ecb3x" [X Link](https://x.com/anyuser/status/1897051405560766681) 2025-03-04T22:27Z 122.8K followers, [----] engagements "☕Afonso et al. show that during #anaphase chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size slowing in smaller cells thereby scaling anaphase. https://bit.ly/4bpoMCU https://bit.ly/4bpoMCU" [X Link](https://x.com/anyuser/status/1897053282251759834) 2025-03-04T22:35Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here is the N&Vs article written by Nicoletta I. Petridou. https://bit.ly/4kniCrb https://rdcu.be/ecb3M https://bit.ly/4kniCrb https://rdcu.be/ecb3M" [X Link](https://x.com/anyuser/status/1897053284508348895) 2025-03-04T22:35Z 122.8K followers, [----] engagements "☕Wang et al. profile the #translatome of #hematopoietic #StemCells (HSCs) and downstream progenitors and lineages. They identify the SNORD113114 cluster as a modulator of translation and self-renewal in HSCs. https://bit.ly/4i2xxVX https://rdcu.be/ecb3W https://bit.ly/4i2xxVX https://rdcu.be/ecb3W" [X Link](https://x.com/anyuser/status/1897054864703938582) 2025-03-04T22:41Z 122.8K followers, [----] engagements "Glucosylceramide-induced ectosomes propagate pathogenic -synuclein in Parkinsons disease Nature Cell Biology Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein with relevance to Parkinson’s disease pathology" [X Link](https://www.nature.com/articles/s41556-026-01871-6) 2026-02-12T17:26Z 2.1M followers, [----] engagements "Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis Nature Cell Biology This Review presents the metabolic landscape of HSCs including the link of key metabolic features to self-renewal and differentiation and highlights how their alterations contribute to haematological disorders particularly leukaemogenesis" [X Link](https://www.nature.com/articles/s41556-026-01872-5) 2026-02-11T11:26Z 2.1M followers, [----] engagements "☕Oborsk-Oplov et al. report a conserved #mitochondria avoidance segment in the cytosolic ribosomal protein uS5 that prevents mistargeting of uS5 to the mitochondrial matrix and ensures cytosolic #ribosomal assembly. https://bit.ly/3EZV8bi https://rdcu.be/ecb32 https://bit.ly/3EZV8bi https://rdcu.be/ecb32" [X Link](https://x.com/anyuser/status/1897056566702182812) 2025-03-04T22:48Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here is the N&Vs article written by Kanda M. Borgognoni & Robin E. Stanley. https://bit.ly/4iq3iYV https://rdcu.be/ecb4a https://bit.ly/4iq3iYV https://rdcu.be/ecb4a" [X Link](https://x.com/anyuser/status/1897056568878989498) 2025-03-04T22:48Z 122.8K followers, [----] engagements "☕@ScientistJoanna @RuggeroDavide & co perform a genome-wide CRISPRi screen and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth. https://bit.ly/41rGfGb https://rdcu.be/ecb4e https://bit.ly/41rGfGb https://rdcu.be/ecb4e" [X Link](https://x.com/anyuser/status/1897058938300064186) 2025-03-04T22:57Z 122.8K followers, [----] engagements "🍰Interested in reading more about the study Here is the N&Vs article written by Zainab Hussain & Mara H. Sherman. https://bit.ly/4knA1js https://rdcu.be/ecb4q https://bit.ly/4knA1js https://rdcu.be/ecb4q" [X Link](https://x.com/anyuser/status/1897058940464324686) 2025-03-04T22:57Z 122.8K followers, [----] engagements "👋🏽A reminder to all our authors and readers that you can now find us and connect with us on Bluesky: @natcellbio.nature.com #Science #CellBiology #ScienceCommunication" [X Link](https://x.com/anyuser/status/1936193339134509487) 2025-06-20T22:43Z 122.8K followers, 14.1K engagements "FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation thereby preventing the induction of ferroptosis" [X Link](https://www.nature.com/articles/s41556-025-01790-y) 2025-10-29T15:17Z 228.6M followers, 20.3K engagements "Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier Nature Cell Biology Kozai Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shapes barrier dynamics and disorder within the pore" [X Link](https://www.nature.com/articles/s41556-025-01812-9) 2025-12-02T10:05Z 228.6M followers, [--] engagements "Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration Nature Cell Biology Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquitylation and promoting mitochondrial respiration" [X Link](https://www.nature.com/articles/s41556-025-01799-3) 2025-11-01T06:28Z 228.6M followers, [----] engagements "In vivo models bring FSP1 inhibitors to life Nature Cell Biology FSP1 is a key suppressor of lipid peroxidation and ferroptosis yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in vivo establishing it as a context-specific cancer vulnerability and highlighting the therapeutic potential of FSP1 inhibition" [X Link](https://www.nature.com/articles/s41556-025-01849-w) 2025-12-12T16:13Z 228.6M followers, [----] engagements "The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to heterochromatin detachment and derepression of gene and transposon expression" [X Link](https://www.nature.com/articles/s41556-025-01703-z) 2025-08-02T02:11Z 208.1M followers, [--] engagements "Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS Nature Cell Biology Wang et al. identify ZNFX1 as a mitochondria-localised sensor that recognizes viral dsRNA and induces a type I interferon response thereby restricting virus infection" [X Link](https://www.nature.com/articles/s41556-019-0416-0) 2019-11-15T06:59Z 208.1M followers, [--] engagements "Inheriting chromosome conformation Nature Cell Biology Chromosomes unfold and refold each time cells divide. A study by Schooley et al. demonstrates that chromosome-intrinsic and cytoplasmic factors uniquely contribute to interphase chromosome structure with new possibilities for how gene expression programs are passed from mother cells to daughter cells" [X Link](https://www.nature.com/articles/s41556-025-01851-2) 2025-12-23T02:57Z 228.6M followers, [---] engagements "The multifaceted contributions of mitochondria to cellular metabolism Nature Cell Biology Nature Cell Biology - The multifaceted contributions of mitochondria to cellular metabolism" [X Link](https://www.nature.com/articles/s41556-018-0124-1) 2025-11-10T14:36Z 228.6M followers, [--] engagements "Spermidine is essential for fasting-mediated autophagy and longevity Nature Cell Biology Hofer et al. show that fasting promotes the synthesis of spermidine which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner" [X Link](https://www.nature.com/articles/s41556-024-01468-x) 2025-12-29T15:13Z 2.1M followers, 801.9K engagements "Modelling co-development between the somites and neural tube in human trunk-like structures Nature Cell Biology Makwana Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage [----] of development. They use them to model and study the development of the thoracic and lumbar trunk" [X Link](https://www.nature.com/articles/s41556-025-01813-8) 2025-12-16T12:10Z 228.6M followers, 10.2K engagements "CoCo-ST detects global and local biological structures in spatial transcriptomics datasets Nature Cell Biology Wu Zhang and colleagues introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST) a graph contrastive learning-based method for spatial transcriptomics analysis that detects low-variance structures" [X Link](https://www.nature.com/articles/s41556-025-01781-z) 2025-10-17T15:32Z 208.1M followers, [----] engagements "dCas9-based gene editing for cleavage-free genomic knock-in of long sequences Nature Cell Biology Wang Qu et al. developed a genome-editing system utilizing catalytically inactive Cas9 fused to microbial single-strand annealing proteins for kilobase-scale insertion in human cells without introducing DNA nicks or breaks" [X Link](https://nature.com/articles/s41556-021-00836-1) 2026-01-21T03:46Z 2.1M followers, [--] engagements "T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response Nature Cell Biology Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity level and is T follicular helper cell-dependent" [X Link](https://www.nature.com/articles/s41556-025-01833-4) 2025-12-30T14:38Z 228.6M followers, [----] engagements "Decoding the proton veil around lysosomes Nature Cell Biology A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen identifying a nanoscale regulatory interface that links luminal pH TMEM175-mediated proton efflux organelle positioning and neurodegeneration" [X Link](https://www.nature.com/articles/s41556-025-01869-6) 2026-01-26T13:41Z 2.1M followers, [----] engagements "Championing scientist migration Nature Cell Biology Science thrives on the free exchange of ideas and collaboration between diverse groups with researcher mobility greatly accelerating progress. With isolationist rhetoric increasingly dominating the political discourse in many countries it is important to recognize the value of migration in science" [X Link](https://www.nature.com/articles/s41556-019-0283-8) 2019-02-05T10:37Z 208.1M followers, [--] engagements "Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm Nature Cell Biology Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm" [X Link](https://www.nature.com/articles/s41556-025-01828-1) 2025-12-23T02:57Z 228.6M followers, [---] engagements "Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma Nature Cell Biology Mohri et al. show that in response to genotoxic stress melanocyte stem cells undergo senescence-associated differentiation causing their depletion and protecting them against melanomagenesis. This process is suppressed by carcinogens" [X Link](https://www.nature.com/articles/s41556-025-01769-9) 2025-10-21T21:26Z 228.6M followers, [----] engagements "From fallout to renewal Nature Cell Biology In the wake of the atomic bombings of Hiroshima and Nagasaki urgent efforts aimed at understanding radiation sickness catalysed the birth of bone marrow transplantation and stem cell biology. In this historical Comment we highlight the critical role of government support in empowering fundamental studies that can lead often unexpectedly to considerable advances for science and human health" [X Link](https://www.nature.com/articles/s41556-025-01826-3) 2025-12-01T14:09Z 228.6M followers, [----] engagements "Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein Nature Cell Biology Rajshekar et al. show that a hierarchy of affinities layers pericentromeric heterochromatin around nucleoli with the RNA helicase Pitchoune (DDX18) acting as a key dual-affinity linker in Drosophila melanogaster" [X Link](https://www.nature.com/articles/s41556-025-01806-7) 2025-11-24T21:52Z 228.6M followers, [----] engagements "DNA nanodevices detect an acidic nanolayer on the lysosomal surface Nature Cell Biology Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH" [X Link](https://www.nature.com/articles/s41556-025-01855-y) 2026-01-21T13:07Z 228.6M followers, [----] engagements "Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues Nature Cell Biology Yuan et al. present S2-omics an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments" [X Link](https://www.nature.com/articles/s41556-025-01811-w) 2025-12-01T17:52Z 228.6M followers, 15.1K engagements "Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells Nature Cell Biology della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity" [X Link](https://www.nature.com/articles/s41556-025-01814-7) 2025-11-18T15:51Z 228.6M followers, 26.1K engagements "PEX39 facilitates the peroxisomal import of PTS2-containing proteins Nature Cell Biology Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins" [X Link](https://www.nature.com/articles/s41556-025-01711-z) 2025-07-31T17:07Z 228.6M followers, [----] engagements "Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimers disease Nature Cell Biology Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology" [X Link](https://www.nature.com/articles/s41556-025-01623-y) 2025-09-04T14:55Z 208.1M followers, [---] engagements "💫NEW by Zhang & co: [--] distinct types of #myeloid#Bcell interaction may signal solid tumor-induced immunosuppression and correlate with complete responses to #immunotherapy in #BreastCancer patients. @bcmhouston @BCMCancerCenter https://www.nature.com/articles/s41556-024-01508-6 https://rdcu.be/dVcfx https://www.nature.com/articles/s41556-024-01508-6 https://rdcu.be/dVcfx" [X Link](https://x.com/NatureCellBio/status/1839470011188224399) 2024-09-27T01:00Z 123.8K followers, [----] engagements "Our November issue is now live Cover image: "Controlling EMT in development and metastasis" by Kang and co () http://t.co/MbJtF8AO http://bit.ly/Tuv2eF http://bit.ly/Tuv2eF" [X Link](https://x.com/NatureCellBio/status/265805540637151232) 2012-11-06T13:19Z 123.2K followers, [--] engagements "Cerebral organoids display dynamic clonal growth and tunable tissue replenishment - Nature Cell Biology Lindenhofer Haendeler Esk Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands" [X Link](https://www.nature.com/articles/s41556-024-01412-z) 2024-05-07T00:00Z 125.1K followers, [----] engagements "NAD+ regulates nucleotide metabolism and genomic DNA replication Nature Cell Biology Munk et al. show that exogenous NAD+ but not its precursors induces metabolic changes in mitochondria affecting nucleotide metabolism with impacts on genomic DNA synthesis and genome integrity" [X Link](https://www.nature.com/articles/s41556-023-01280-z) 2025-10-18T03:15Z 208.1M followers, [---] engagements "To eat or not to eat - Nature Cell Biology Nature Cell Biology - To eat or not to eat" [X Link](https://nature.com/articles/s41556-024-01560-2) 2024-11-11T00:00Z 125.3K followers, [----] engagements "RNAs kiss and translate in germ granules Nature Cell Biology The assembly of germ granules remains unknown but recent attention to the role of RNA structure in membrane-less organelle assembly is changing our understanding of RNAs in the cell. Two studies now show how RNARNA interactions drive germ granule assembly and how germ granules spatially regulate embryonic mRNA translation" [X Link](https://www.nature.com/articles/s41556-024-01502-y) 2024-10-04T17:06Z 208.1M followers, [---] engagements "Spatial and functional separation of mTORC1 signalling in response to different amino acid sources - Nature Cell Biology Fernandes Angelidaki et al. provide evidence supporting the spatial separation of mTORC1 activation and signalling. Differentially localized mTORC1 complexes phosphorylate distinct substrates in response to different amino acid supplies" [X Link](https://www.nature.com/articles/s41556-024-01523-7) 2024-10-09T00:00Z 208.1M followers, [----] engagements "Deciphering glioma susceptibility Nature Cell Biology The regulatory mechanisms that drive oncogene expression in gliomas remain poorly understood. A study now identifies a role for widespread rearrangements of the enhancer connectome. Such rearrangements are linked to known genetic risk variants revealing how genetic predisposition contributes to malignancy" [X Link](https://www.nature.com/articles/s41556-025-01782-y) 2025-10-15T01:54Z 208.1M followers, [--] engagements "The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity - Nature Cell Biology Hockemeyer et al. demonstrate that HSF1 activation inhibits cytokine production and cytotoxic activity in NK cells to impair anti-tumour immune responses" [X Link](https://www.nature.com/articles/s41556-024-01490-z) 2024-09-02T00:00Z 125K followers, [----] engagements "Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks Nature Cell Biology Saur Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes independently of de novo recruitment of RNA polymerase II/III as a result of DSB-induced transcriptional repression" [X Link](https://www.nature.com/articles/s41556-025-01669-y) 2025-08-05T20:18Z 208.1M followers, [---] engagements "Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition - Nature Cell Biology Schwab Rao et al. report that Zeb1 mediates enhanced ferroptosis sensitivity in cancer cells after EMT activation associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio" [X Link](https://www.nature.com/articles/s41556-024-01464-1) 2024-07-15T00:00Z 125.6K followers, [----] engagements "Forcing cell fate Nature Cell Biology The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces long considered background players in guiding this transition are essential regulators of chromatin accessibility and cell fate decisions" [X Link](https://www.nature.com/articles/s41556-025-01775-x) 2025-09-30T19:16Z 208.1M followers, [--] engagements "An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory Nature Cell Biology Lanna and colleagues discover extracellular vesicle-mediated transfer of telomeres from antigen-presenting cells to T cells which enables elongation of chromosomes protection against replicative senescence and long-term immune defence" [X Link](https://www.nature.com/articles/s41556-022-00991-z) 2022-10-11T08:03Z 2.1M followers, 70.2K engagements "Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation - Nature Cell Biology Bernab-Rubio et al. report that dedifferentiation of Gata6+ epidermal cells occurs during wound healing or mechanical expansion of the epidermis through a Myc-dependent process that resembles reversal of differentiation" [X Link](https://www.nature.com/articles/s41556-023-01234-5) 2023-09-21T00:00Z 125.6K followers, [----] engagements "Keeping membraneless organelles apart - Nature Cell Biology How spatial organization in the cell is achieved on the organelle scale is unclear. A new study finds that tethering specific proteins near the surface of micelle-like paraspeckles modifies their properties and determines whether these subnuclear organelles are separate from adhere to or are engulfed by nuclear speckles" [X Link](https://www.nature.com/articles/s41556-023-01265-y) 2023-11-06T00:00Z 125K followers, [----] engagements "Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer Nature Cell Biology Al-Hilal Chrysovergi et al. identify a role for durotaxis in lung fibrosis and metastatic pancreatic cancer mediated by the FAKpaxillin mechanosensor complex and demonstrate therapeutic targeting of this pathway using the small molecule JP-153" [X Link](https://www.nature.com/articles/s41556-025-01697-8) 2025-09-16T20:35Z 208.1M followers, [----] engagements "Noncanonical inheritance of phenotypic information by protein amyloids - Nature Cell Biology Eroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein loss results in a transgenerational feminization phenotype through ectopic GLD-1 expression" [X Link](https://www.nature.com/articles/s41556-024-01494-9) 2024-09-02T00:00Z 208.1M followers, 212.4K engagements "Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment Nature Cell Biology Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy" [X Link](https://www.nature.com/articles/s41556-023-01274-x) 2023-12-20T19:16Z 228.6M followers, [---] engagements "An architectural role of specific RNARNA interactions in oskar granules - Nature Cell Biology Bose Rankovic et al. show that a specific RNARNA kissing-loop interaction plays a crucial role in driving biomolecular condensation of ribonucleoprotein granules in the Drosophila germline" [X Link](https://www.nature.com/articles/s41556-024-01519-3) 2024-10-01T00:00Z 208.1M followers, 25.5K engagements "LIANA+ provides an all-in-one framework for cellcell communication inference - Nature Cell Biology Dimitrov et al. present LIANA+ a framework that unifies and extends approaches to study inter- and intracellular signalling from diverse mediators captured from single-cell spatially resolved and multi-omics data" [X Link](https://www.nature.com/articles/s41556-024-01469-w) 2024-09-02T00:00Z 125.6K followers, 29K engagements "EPAC1 enhances brown fat growth and beige adipogenesis Nature Cell Biology Reverte-Salisa et al. show that in preadipocytes EPAC1 enhances brown adipose tissue growth and increases the function of thermogenic fat in obesogenic conditions. Activation of EPAC1 induces human brown adipocyte proliferation and differentiation" [X Link](https://www.nature.com/articles/s41556-023-01311-9) 2024-03-06T17:30Z 208.1M followers, [---] engagements "H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos - Nature Cell Biology Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition following H2AK119 mono-ubiquitylation deposition. It is also required for the subsequent H3K27me3 deposition at the blastocyst stage" [X Link](https://www.nature.com/articles/s41556-024-01553-1) 2024-10-31T00:00Z 125.3K followers, 41.1K engagements "Gasdermins as evolutionarily conserved executors of inflammation and cell death - Nature Cell Biology Gasdermins are a family of proteins that form membrane pores and elicit pyroptosis. This Review discusses recent work highlighting their regulation and emerging biological roles including in non-lethal pore formation and host defence" [X Link](https://www.nature.com/articles/s41556-024-01474-z) 2024-08-26T00:00Z 2.1M followers, [----] engagements "Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth - Nature Cell Biology Guo Hong et al. report that TET2 condensation maintains proper DNA demethylation at specific genomic loci which can be targeted to alter gene expression and impair leukaemia growth" [X Link](https://www.nature.com/articles/s41556-024-01496-7) 2024-09-09T00:00Z 125.6K followers, 12.2K engagements "Solid tumour-induced systemic immunosuppression involves dichotomous myeloidB cell interactions Nature Cell Biology Hao Shen and colleagues identify and characterize two distinct types of myeloidB cell interaction that may signal solid tumour-induced immunosuppression and can correlate with complete responses to immunotherapy in patients with breast cancer" [X Link](https://www.nature.com/articles/s41556-024-01508-6) 2024-09-27T01:00Z 228.6M followers, [----] engagements "ARF1 compartments direct cargo flow via maturation into recycling endosomes - Nature Cell Biology Stockhammer Adarska et al. describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-Golgi sorting. Shedding of ARF1 and maturation into recycling endosomes drives sorting of secretory and endocytic recycling cargo" [X Link](https://www.nature.com/articles/s41556-024-01518-4) 2024-10-04T00:00Z 125.4K followers, 18.3K engagements "HSF1 renders NK cells too stressed to respond - Nature Cell Biology The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells the HSF1 transcription factor binds to mediators of effector function negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy" [X Link](https://www.nature.com/articles/s41556-024-01472-1) 2024-09-02T00:00Z 125.6K followers, [--] engagements "Spatiotemporal coordination of actin regulators generates invasive protrusions in cellcell fusion - Nature Cell Biology Lu et al. reveal the spatiotemporal coordination between two nucleation-promoting factors WAVE and N-WASP and two actin-bundling proteins dynamin and WIP in generating invasive protrusions at the mammalian myoblast fusogenic synapse" [X Link](https://www.nature.com/articles/s41556-024-01541-5) 2024-11-01T00:00Z 125.3K followers, [----] engagements "Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover - Nature Cell Biology Aeby et al. report that DCP1A negatively regulates Tsix RNA abundance by suppressing its transcriptional elongation and RNA stability thus contributing to X-chromosome inactivation" [X Link](https://www.nature.com/articles/s41556-020-0558-0) 2020-08-17T00:00Z 125.6K followers, [--] engagements "p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells - Nature Cell Biology Majewska et al. show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1 by downregulating its proteasome-mediated ubiquitin-dependent degradation leading to their accumulation in ageing and chronic inflammation" [X Link](https://www.nature.com/articles/s41556-024-01465-0) 2024-08-05T00:00Z 125.6K followers, [--] engagements "Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart Nature Cell Biology Dardano et al. generate human pluripotent stem cell-derived cardiac organoids capable of undergoing endothelial-to-haematopoietic transition and producing haematopoietic cells" [X Link](https://www.nature.com/articles/s41556-024-01526-4) 2024-10-17T06:00Z 124.5K followers, [----] engagements "Docking a flexible basket onto the core of the nuclear pore complex - Nature Cell Biology Stankunas and Khler define how the nucleoplasmic portion of the nuclear pore complex (NPC) the basket docks onto the NPC core by integrating AlphaFold-based interaction screens electron microscopy and membrane-templated reconstitutions" [X Link](https://www.nature.com/articles/s41556-024-01484-x) 2024-08-13T00:00Z 125.6K followers, [--] engagements "Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells Nature Cell Biology McCreery Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes" [X Link](https://www.nature.com/articles/s41556-025-01767-x) 2025-09-30T19:18Z 121.8K followers, [--] engagements "Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor - Nature Cell Biology Nicastro Brohe et al. find that the fatty acid synthesis intermediate malonyl-CoA inhibits mTORC1 showing mTORC1 senses the capacity of a cell to synthesise fatty acids and linking fatty acid generation with the overall biosynthetic output through mTORC1" [X Link](https://www.nature.com/articles/s41556-023-01198-6) 2023-08-10T00:00Z 125.6K followers, 11.2K engagements "On the causal role of retromer-dependent endosomal recycling in Alzheimers disease - Nature Cell Biology Recent findings ranging from genetics to structural biology together with studies in human neurons animal models and patient brains implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimers disease" [X Link](https://www.nature.com/articles/s41556-023-01245-2) 2023-10-06T00:00Z 125.5K followers, [----] engagements "Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferroptosis which could be exploited to treat cancers" [X Link](https://www.nature.com/articles/s41556-024-01425-8) 2024-06-10T00:00Z 2.1M followers, [----] engagements "Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGF and Hippo signalling to drive regeneration - Nature Cell Biology Using deep single-nucleus multi-omics profiling Fink et al. report transition states between crypt epithelial cells and a revival stem cell lineage. They find that the TGF and Hippo signalling pathways cooperatively drive intestinal regeneration" [X Link](https://www.nature.com/articles/s41556-024-01550-4) 2024-11-15T00:00Z 125.1K followers, [----] engagements "A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate Nature Cell Biology Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate" [X Link](https://www.nature.com/articles/s41556-025-01770-2) 2025-09-17T20:32Z 208.1M followers, [----] engagements "Hepatocellular senescence induces multi-organ senescence and dysfunction via TGF - Nature Cell Biology Kiourtis et al. show that liver senescence triggers senescence and dysfunction in other organs through TGF secretion from the liver" [X Link](https://www.nature.com/articles/s41556-024-01543-3) 2024-11-13T00:00Z 125K followers, 10.7K engagements "Blebbisomes are large organelle-rich extracellular vesicles with cell-like properties Nature Cell Biology Jeppesen Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles" [X Link](https://www.nature.com/articles/s41556-025-01621-0) 2025-02-22T08:34Z 2.1M followers, 61.8K engagements "The ETS transcription factor ETV6 constrains the transcriptional activity of EWSFLI to promote Ewing sarcoma - Nature Cell Biology Independent but complementary studies from Vakoc and Stegmaier identify and characterize a role for ETV6 in counteracting the transcriptional activity of EWSFLI during Ewing sarcoma development which may be targeted for therapeutic benefits" [X Link](https://www.nature.com/articles/s41556-022-01059-8) 2023-01-19T00:00Z 208.1M followers, [---] engagements "An overview of contemporary theories of ageing Nature Cell Biology This Review provides an overview of modern mechanistic theories and critically examines two main groups of ageing theories—error and program based—in the context of ageing patterns genetic manipulations and longevity drugs" [X Link](https://www.nature.com/articles/s41556-025-01698-7) 2025-07-01T09:42Z 2.1M followers, 41.7K engagements "Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology Zhou et al. describe an intracellular transport pathway of low-density lipoprotein (LDL)LDL receptor from the plasma membrane that bypasses lysosomes and delivers cholesterol to mitochondria for steroidogenesis" [X Link](https://www.nature.com/articles/s41556-023-01160-6) 2023-06-05T00:00Z 125.2K followers, 27.5K engagements "Emerging connections between myelin and Alzheimers disease Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here we discuss emerging evidence that oligodendrocytes may directly contribute to disease pathology and progression" [X Link](https://www.nature.com/articles/s41556-025-01701-1) 2025-08-01T15:35Z 228.6M followers, [----] engagements "FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy - Nature Cell Biology van der Weijden et al. perform genomic proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause" [X Link](https://www.nature.com/articles/s41556-023-01325-3) 2024-01-04T00:00Z 125.1K followers, [----] engagements "Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles - Nature Cell Biology Takakuwa Yamazaki et al. show that the long noncoding RNA NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish nuclear speckles from paraspeckles to preserve their structural identity" [X Link](https://www.nature.com/articles/s41556-023-01254-1) 2023-11-06T00:00Z 125K followers, [----] engagements "MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death Nature Cell Biology Nguyen Collier et al. find a mitochondrialysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate pyroptosis" [X Link](https://www.nature.com/articles/s41556-025-01774-y) 2025-10-13T17:44Z 228.6M followers, 10.8K engagements "Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition - Nature Cell Biology Yuzhalin et al. report that astrocyte-mediated upregulation of Cdk5 in metastatic breast cancer cells inhibits MHC-I expression on the cell surface thereby enabling escape from killing by CD8+ T cells and facilitating brain metastasis" [X Link](https://www.nature.com/articles/s41556-024-01509-5) 2024-09-20T00:00Z 125.6K followers, [----] engagements "FMRP regulates MFF translation to locally direct mitochondrial fission in neurons - Nature Cell Biology Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites where they promote local MFF synthesis and fission at the mitochondrial midzone" [X Link](https://www.nature.com/articles/s41556-024-01544-2) 2024-11-15T00:00Z 125.1K followers, 10.7K engagements "Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells - Nature Cell Biology Zhang et al. uncover different dynamics underlying the maintenance and regulation of H3K9me3-enriched heterochromatin domains in mouse embryonic stem cells and propose that loss of H3K9me3 occurs through two distinct dynamic modes: passive dilution and active removal" [X Link](https://www.nature.com/articles/s41556-024-01547-z) 2024-10-31T00:00Z 125.1K followers, 10.9K engagements "Basic science is not just a foundation Nature Cell Biology Intellectual freedom for scientists unconstrained by commercial interests and direct application fuels unexpected discoveries. Curiosity-driven basic science has yielded a deeper understanding of how life forms develop and function in their environment and has had wide implications for health and our planet. Investing in this is vital for scientific progress and is worth protecting in a democracy" [X Link](https://www.nature.com/articles/s41556-023-01308-4) 2024-01-17T12:49Z 208.1M followers, [---] engagements "Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking - Nature Cell Biology Toettcher McNamara and colleagues use synthetic signal-recording gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt activity into a single pole which defines the gastruloid anteriorposterior axis" [X Link](https://www.nature.com/articles/s41556-024-01521-9) 2024-10-02T00:00Z 125.6K followers, [----] engagements "Mitochondrial heterogeneity and adaptations to cellular needs - Nature Cell Biology Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling" [X Link](https://www.nature.com/articles/s41556-024-01410-1) 2024-05-16T00:00Z 2.1M followers, [----] engagements "Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination - Nature Cell Biology Huang Li An Yang Cui et al. perform a single-cell multi-omics analysis of human spermatogenesis and identify a DNA demethylation event upon meiosis initiation which is associated with meiotic recombination" [X Link](https://www.nature.com/articles/s41556-023-01232-7) 2023-09-18T00:00Z 125.5K followers, [----] engagements "Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Nature Cell Biology Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils" [X Link](https://www.nature.com/articles/s41556-019-0346-x) 2019-07-18T10:12Z 124.5K followers, [--] engagements "Building the epigenetic fortress with PRC2.2 - Nature Cell Biology How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation which is crucial for gene regulation and lineage specification" [X Link](https://www.nature.com/articles/s41556-024-01551-3) 2024-10-31T00:00Z 125.6K followers, [---] engagements "Spindle architecture constrains karyotype evolution - Nature Cell Biology Helsen et al. use experimental evolution and chromosome engineering to probe the link between karyotype changes and the cell division machinery. They conclude that spindle organization dictates the available trajectories for karyotype evolution" [X Link](https://www.nature.com/articles/s41556-024-01485-w) 2024-08-08T00:00Z 125.6K followers, [--] engagements "Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome Nature Cell Biology Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective neuronal physiology and increased seizure susceptibility linking chaperone-mediated autophagy to neuronal excitability" [X Link](https://www.nature.com/articles/s41556-025-01771-1) 2025-10-16T14:38Z 208.1M followers, [---] engagements "Telomere dysfunction in ageing and age-related diseases Nature Cell Biology Rossiello et al. review the contributions of telomere shortening and/or dysfunction to ageing and a broad spectrum of age-associated human diseases" [X Link](https://www.nature.com/articles/s41556-022-00842-x) 2025-10-11T17:22Z 2.1M followers, 70.4K engagements "Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum - Nature Cell Biology Yang et al. show that plasma membrane curvature promotes the site-specific formation of contacts with the endoplasmic reticulum through junctophilin-2 tethers in cardiomyocytes" [X Link](https://www.nature.com/articles/s41556-024-01511-x) 2024-09-17T00:00Z 125.6K followers, 18.4K engagements "Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to anti-osteoporosis treatments" [X Link](https://www.nature.com/articles/s41556-024-01545-1) 2024-11-11T00:00Z 125.2K followers, [----] engagements "NEW ONLINE: We spoke to Kara McKinley (@karalmckinley) assistant professor of stem cell and regenerative biology at @HSCRB about her career and goals for our research community. Find the Q&A here: https://www.nature.com/articles/s41556-022-01083-8 https://rdcu.be/c4poh https://www.nature.com/articles/s41556-022-01083-8 https://rdcu.be/c4poh" [X Link](https://x.com/NatureCellBio/status/1619800765484376064) 2023-01-29T20:52Z 124.5K followers, 62.3K engagements "☕NEW: Zhou et al. describe an intracellular transport pathway of low-density lipoprotein (LDL)LDL receptor from the plasma membrane that bypasses lysosomes and delivers cholesterol to mitochondria for steroidogenesis. https://www.nature.com/articles/s41556-023-01160-6 https://rdcu.be/demjw https://www.nature.com/articles/s41556-023-01160-6 https://rdcu.be/demjw" [X Link](https://x.com/NatureCellBio/status/1668351785411436570) 2023-06-12T20:17Z 125.2K followers, 19.4K engagements "🧋NEW: Chung et al. identify the Troyer syndrome protein spartin as a #lipophagy receptor for #lipiddroplet clearance in vitro and in vivo. @TobiWalther @BobFarese @FandWLab @JeeyunC @MCB_Harvard @SKI_CellBiology" [X Link](https://x.com/NatureCellBio/status/1681279274303537154) 2023-07-19T08:18Z 122.4K followers, 16.9K engagements "🧋NEW: Nicastro Brohe et al. find that #malonylCoA inhibits #mTORC1 thus linking #fattyacid generation with the overall biosynthetic output through mTORC1. @Raf_Nic @laura_brohee @LabVanni @TelemanLab @CDV1893 @DemetriadesLab https://www.nature.com/articles/s41556-023-01198-6 https://www.nature.com/articles/s41556-023-01198-6" [X Link](https://x.com/NatureCellBio/status/1692230488243458247) 2023-08-17T17:42Z 125.6K followers, 11.2K engagements "🍹NEW: Romanauska and Khler manipulate the levels of endogenously produced saturated acyl chains in yeast and show that #NuclearEnvelope and #NuclearPoreComplex function are uniquely sensitive to #lipid acyl chain unsaturation. @MaxPerutzLabs" [X Link](https://x.com/NatureCellBio/status/1693967033992446137) 2023-08-22T12:43Z 121.7K followers, [----] engagements "🍹NEW: @bernstein_lab & co show that macroH2A deficiency in #CancerAssociatedFibroblasts alters #chromatinlooping and #inflammatory gene expression and limits the #AntiTumor response in #melanoma. @TischCancer @IcahnMountSinai @MelanomaReAlli" [X Link](https://x.com/NatureCellBio/status/1698740530752991617) 2023-09-04T16:51Z 121.8K followers, [----] engagements "🍹NEW: Surani Irie & co show that #DMRT1 induction in #PrimordialGermCell-like cells triggers germline commitment but suppresses #pluripotency genes thus promoting the onset of #gametogenesis. @GurdonInstitute" [X Link](https://x.com/NatureCellBio/status/1704839113764184205) 2023-09-21T12:44Z 121.7K followers, [----] engagements "🍹NEW: Huang Li An Yang Cui et al. perform a #singlecell #multiomics analysis of human #spermatogenesis and identify a DNA demethylation event upon #meiosis initiation which is associated with #MeioticRecombination. https://www.nature.com/articles/s41556-023-01232-7 https://rdcu.be/dmW9M https://www.nature.com/articles/s41556-023-01232-7 https://rdcu.be/dmW9M" [X Link](https://x.com/NatureCellBio/status/1706295417816670339) 2023-09-25T13:11Z 125.5K followers, [----] engagements "🍹NEW: @yamashitaflylab @zamore_lab & co show that Y-linked Su(Ste) #piRNAs are produced via 5-to-3 phased-biogenesis initiated by maternally deposited 1360/Hoppel-derived piRNAs silencing Ste in male #germline. @IGainetdinov @WhiteheadInst @MITBiology" [X Link](https://x.com/NatureCellBio/status/1706815969492959343) 2023-09-26T23:40Z 122.4K followers, [----] engagements "🍹NEW: Bernab-Rubio et al. report that #dedifferentiation of Gata6+ #EpidermalCells occurs during #woundhealing or mechanical expansion of the #epidermis through a Myc-dependent process that resembles reversal of differentiation. @KCLstemcells https://www.nature.com/articles/s41556-023-01234-5 https://www.nature.com/articles/s41556-023-01234-5" [X Link](https://x.com/NatureCellBio/status/1707497246642540812) 2023-09-28T20:47Z 125.6K followers, [----] engagements "🍹NEW:@ArdehaliHossein & co find a role for the #HistoneDemethylase KDM3B in sensing #ironlevels and regulating #mTORC1 via #transcriptional repression of mTORC1 pathway components. @nu_fcvrri @NUFeinbergMed @NorthwesternMed @NUMSTP https://www.nature.com/articles/s41556-023-01225-6 https://rdcu.be/dnhYk https://www.nature.com/articles/s41556-023-01225-6 https://rdcu.be/dnhYk" [X Link](https://x.com/NatureCellBio/status/1707504621982204119) 2023-09-28T21:16Z 125.5K followers, [----] engagements "🍹NEW: Timms Mena et al. present a multiplex #CRISPR #screeningplatform capable of assigning #E3ligases to their substrates and degrons at scale. #CRISPRscreening" [X Link](https://x.com/NatureCellBio/status/1707779640490676318) 2023-09-29T15:29Z 122.4K followers, [----] engagements "☕NEW: Zhang et al. report curved adhesions which are #integrin-based adhesions formed in response to membrane curvatures that can be imposed by the overlying #extracellularmatrix fibre geometry. @cuilab_chem @StanfordUChem @Stanford_CHEMH @BianxiaoC" [X Link](https://x.com/NatureCellBio/status/1708963076140089558) 2023-10-02T21:52Z 121.7K followers, [----] engagements "☕NEW: Churchman & co share #CRISPRscreen for factors altering the levels of [--] dual-genome-encoded #ComplexIV subunits and identify PREPL and NME6 as genes that connect #MitochondrialMetabolism to #mtDNA expression. @fiddle @GyPrak" [X Link](https://x.com/NatureCellBio/status/1709553146916143352) 2023-10-04T12:56Z 121.5K followers, [----] engagements "🍵Read our new Comment by Small & co on #retromer-dependent #endosomal recycling in #Alzheimersdisease. PDF: https://www.nature.com/articles/s41556-023-01245-2 https://rdcu.be/dn6Le https://www.nature.com/articles/s41556-023-01245-2 https://rdcu.be/dn6Le" [X Link](https://x.com/NatureCellBio/status/1711358078879170720) 2023-10-09T12:28Z 125.5K followers, [----] engagements "☕NEW: Lusk King (@LuskingL @Plusk4u) & co find a grommet-like role for #ESCRTs. The grommet works with #spindle pole body components that establish a #diffusionbarrier to maintain compartmentalization. @NicholasAder @YaleCellBio" [X Link](https://x.com/NatureCellBio/status/1711362794199581164) 2023-10-09T12:47Z 122.4K followers, [----] engagements "☕NEW: @YoshiakiKubota Takubo & co perform #SingleCellRNASequencing and identify a #BoneMarrow #EndothelialCell subtype that contributes to the acquisition of bone strength and offers a distinct #HematopoieticStemCell niche. @Keio_univ_PR" [X Link](https://x.com/NatureCellBio/status/1712817922781921493) 2023-10-13T13:09Z 121.8K followers, [----] engagements "🍵Read our new Comment by @CreweLab @SnigdhaTiash and @BrestoffLab on #MitochondriaTransfer:" [X Link](https://x.com/NatureCellBio/status/1717511398857879895) 2023-10-26T12:00Z 121.3K followers, [----] engagements "☕NEW: Wang Chen & co report that the secretory coat protein complex COPII undergoes liquidliquid #PhaseSeparation that is tuned by #manganese in the cytosol to impact #lipoprotein secretion" [X Link](https://x.com/NatureCellBio/status/1721522489388331068) 2023-11-06T13:38Z 121.5K followers, 17.6K engagements "☕NEW: Hicks (@Mic_Hicks) Pyle (@apyle) & co report in an Open Access study that human regenerating #myofibres expressing #ACTC1 substantially contribute to supporting #PAX7+ #skeletalmuscle progenitor cells. #MuscleRegeneration" [X Link](https://x.com/NatureCellBio/status/1722609735872938015) 2023-11-09T13:39Z 121.5K followers, [----] engagements "☕NEW: Through a #CRISPR-activation screen Ravid Lustig et al. show that #GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate #Xchromosome inactivation in early #MouseEmbryos. @EddaGSchulz @MPI_MolGen" [X Link](https://x.com/NatureCellBio/status/1724417896493826260) 2023-11-14T13:23Z 122.4K followers, [----] engagements "☕NEW: Takakuwa Yamazaki et al. show that the #LongnoncodingRNA #NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish #nuclearspeckles from #paraspeckles to preserve their structural identity. https://www.nature.com/articles/s41556-023-01254-1 https://rdcu.be/dq96p https://www.nature.com/articles/s41556-023-01254-1 https://rdcu.be/dq96p" [X Link](https://x.com/NatureCellBio/status/1724770964733346246) 2023-11-15T12:46Z 125K followers, [----] engagements "🎁Interested in reading more about the study Here is the N&Vs article written by Miroslav Dundr and Jeremy D. Schmit: https://www.nature.com/articles/s41556-023-01265-y https://rdcu.be/dq96V https://www.nature.com/articles/s41556-023-01265-y https://rdcu.be/dq96V" [X Link](https://x.com/NatureCellBio/status/1724770967799419062) 2023-11-15T12:46Z 125K followers, [----] engagements "☕In this issue: Through a #CRISPR-activation screen @EddaGSchulz & co show that #GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate #Xchromosome inactivation in early #MouseEmbryos" [X Link](https://x.com/NatureCellBio/status/1727416661165101446) 2023-11-22T20:00Z 121.8K followers, [----] engagements "💫NEW: Tang & co from @Westlake_Uni describe #mitopherogenesis: the secretion of #mitochondria in mitophers during #SpermDevelopment in C. elegans which controls the #mitochondrial pool and ensure #fertility. #ExtracellularVesicles" [X Link](https://x.com/NatureCellBio/status/1728897341527335219) 2023-11-26T22:03Z 121.7K followers, [----] engagements "💫NEW: @DLawsonlab & co identify and characterize a #tumour-suppressive role for #microglia that mediates a pro-inflammatory response to restrict brain #metastasis in #BreastCancer. #CancerResearch" [X Link](https://x.com/NatureCellBio/status/1729325739248427020) 2023-11-28T02:26Z 121.7K followers, 11K engagements "💫NEW: @SJMorrison_ @Bo_Shen_ & co report that #LeptinReceptor+ #StromalCells sustain #BoneMarrow nerves by producing NGF. Upon myeloablation nerves promote marrow regeneration by increasing the production of growth factors by leptin receptor+ cells" [X Link](https://x.com/NatureCellBio/status/1730938617214759227) 2023-12-02T13:15Z 121.7K followers, [----] engagements "☕🎄In this issue: Munk et al. show that exogenous NAD+ but not its precursors induces metabolic changes in #mitochondria affecting #nucleotide metabolism with impacts on genomic #DNAsynthesis and #GenomeIntegrity. @cancer_dk" [X Link](https://x.com/NatureCellBio/status/1735295827697115491) 2023-12-14T13:49Z 121.8K followers, [----] engagements "💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics" [X Link](https://x.com/NatureCellBio/status/1742179183944417654) 2024-01-02T13:41Z 121.7K followers, [----] engagements "🎂Nature Cell Biology is turning [--] and we are celebrating [--] years of excellence in #cellbiology with a series of commissioned content and a collection of research articles across the journals broad scope. Read the Editorial:" [X Link](https://x.com/NatureCellBio/status/1747983759335461049) 2024-01-18T14:06Z 122.4K followers, [----] engagements "☕In this issue: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics" [X Link](https://x.com/NatureCellBio/status/1751061461399420985) 2024-01-27T01:56Z 121.8K followers, [----] engagements "☕In this issue: Son et al. show that #AMPK- & PP2A-dependent #p300 nucleocytoplasmic shuttling regulates #mTORC1 activity in response to nutrient status. Models of HutchinsonGilford #progeria display increased cytoplasmic p300 and mTORC1 hyperactivation" [X Link](https://x.com/NatureCellBio/status/1764470821194465548) 2024-03-04T02:00Z 122.9K followers, 13K engagements "📢Join us in this Nature conference on September 23-25 in Beijing Register now for the '#Mitochondria and #Immunity' meeting organized by @NatureCellBio @NatMetabolism @NatImmunol and Nankai University. Abstract submission deadline: Aug [--] [----] https://conferences.nature.com/event/Mitochondria/summary https://conferences.nature.com/event/Mitochondria/summary" [X Link](https://x.com/NatureCellBio/status/1775875262594400658) 2024-04-04T13:17Z 123.3K followers, [----] engagements "☕In this issue: New Review article by @OlzmannLab & @alymathiowetz on #LipidDroplet biogenesis mechanisms their role in fatty acid flux in lipotoxicity and #CellDeath and more 👉🏽Read here: https://rdcu.be/dEmCO https://www.nature.com/articles/s41556-024-01364-4 https://rdcu.be/dEmCO https://www.nature.com/articles/s41556-024-01364-4" [X Link](https://x.com/NatureCellBio/status/1778215134005211453) 2024-04-11T00:15Z 123.3K followers, 15.2K engagements "A study by @Marteijnlab @oncodeinstitute @MolecularGenet3 & co: https://www.nature.com/articles/s41556-024-01394-y https://www.nature.com/articles/s41556-024-01394-y" [X Link](https://x.com/NatureCellBio/status/1785284319482712195) 2024-04-30T12:25Z 123.5K followers, [----] engagements "☕In this issue: A Comment on #VolumeElectronMicroscopy standards in sample preparation and image acquisition for enhanced reproducibility and data reuse. https://www.nature.com/articles/s41556-024-01381-3 https://rdcu.be/dGMhZ https://www.nature.com/articles/s41556-024-01381-3 https://rdcu.be/dGMhZ" [X Link](https://x.com/NatureCellBio/status/1786922508911853800) 2024-05-05T00:55Z 123.6K followers, [----] engagements "💫NEW by Palmulli Couty et al: CD63 promotes #cholesterol accumulation in intraluminal vesicles (ILVs) at the expense of retrieval from #endosomes; cholesterol stored in ILVs and exosomes is recovered in an NPC1-dependent manner. https://www.nature.com/articles/s41556-024-01432-9 https://rdcu.be/dNCzQ https://www.nature.com/articles/s41556-024-01432-9 https://rdcu.be/dNCzQ" [X Link](https://x.com/NatureCellBio/status/1811869465446924521) 2024-07-12T21:05Z 124.4K followers, [----] engagements "💫2 new studies by Agarwal et al. and Wang et al. show that vesicle-associated membrane protein [--] (VAMP2) interacts with and regulates #AlphaSynuclein #BiomolecularCondensation affecting -synuclein function which may prevent pathological amyloid aggregation. 👇🏾see below:" [X Link](https://x.com/NatureCellBio/status/1815434803145027613) 2024-07-22T17:12Z 124.4K followers, [----] engagements "💫NEW: Sun Tao Han et al. identify the Rabs involved in unconventional protein secretion mediated by TMED10 and in ERGolgi intermediate compartment organization. https://www.nature.com/articles/s41556-024-01445-4 https://rdcu.be/dOAv5 https://www.nature.com/articles/s41556-024-01445-4 https://rdcu.be/dOAv5" [X Link](https://x.com/NatureCellBio/status/1815507116335227112) 2024-07-22T22:00Z 124.5K followers, [----] engagements "💫NEW: Wu & co report that upon ultraviolet-C radiation full-length #GSDME can induce #pyroptosis without cleavage. https://www.nature.com/articles/s41556-024-01463-2 https://rdcu.be/dQQA5 https://www.nature.com/articles/s41556-024-01463-2 https://rdcu.be/dQQA5" [X Link](https://x.com/NatureCellBio/status/1823426525632348488) 2024-08-13T18:28Z 124.2K followers, [----] engagements "💫NEW: Schwab Rao et al. report that Zeb1 mediates enhanced #ferroptosis sensitivity in #cancer cells after #EMT activation associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio. https://www.nature.com/articles/s41556-024-01464-1 https://www.nature.com/articles/s41556-024-01464-1" [X Link](https://x.com/NatureCellBio/status/1824006567898779879) 2024-08-15T08:53Z 125.6K followers, [----] engagements "💫NEW: @JuliaMMagdalena @amitmechaging @KrizhanovskyLab & co show that #p16-expressing #senescent cells enhance PD-L1 stability by downregulating its proteasome-mediated degradation leading to their accumulation in aging and chronic inflammation. https://www.nature.com/articles/s41556-024-01465-0 https://www.nature.com/articles/s41556-024-01465-0" [X Link](https://x.com/NatureCellBio/status/1830646620687360123) 2024-09-02T16:39Z 125.6K followers, [----] engagements "💫NEW: Guo Hong et al. report that #TET2 condensation maintains proper #DNAdemethylation at specific genomic loci which can be targeted to alter gene expression and impair #leukemia growth. @Yun_Nancy_Huang @ZhouLaboratory https://www.nature.com/articles/s41556-024-01496-7 https://rdcu.be/dUBQM https://www.nature.com/articles/s41556-024-01496-7 https://rdcu.be/dUBQM" [X Link](https://x.com/NatureCellBio/status/1837467060114231460) 2024-09-21T12:21Z 125.6K followers, 12.2K engagements "💫NEW: Yang et al show that #PlasmaMembrane curvature promotes the site-specific formation of contacts with the #EndoplasmicReticulum through junctophilin-2 tethers in #cardiomyocytes. @cuilab_chem @StanfordUChem @Stanford_CHEMH @BianxiaoC @YangYang0511 https://www.nature.com/articles/s41556-024-01511-x https://www.nature.com/articles/s41556-024-01511-x" [X Link](https://x.com/NatureCellBio/status/1839643401270292945) 2024-09-27T12:29Z 125.6K followers, [----] engagements "💫NEW: Yuzhalin et al. show that #astrocyte-mediated Cdk5 upregulation in metastatic #BreastCancer inhibits MHC-I cell surface expression thus enabling escape from killing by #CD8T cells and facilitating #BrainMetastasis. https://www.nature.com/articles/s41556-024-01509-5 https://rdcu.be/dVNgf https://www.nature.com/articles/s41556-024-01509-5 https://rdcu.be/dVNgf" [X Link](https://x.com/NatureCellBio/status/1841508240162529712) 2024-10-02T15:59Z 125.6K followers, [----] engagements "💫NEW: Bose (@MainakB78580463) Rankovic et al. show that a specific RNARNA kissing-loop interaction plays a crucial role in driving #BiomolecularCondensation of #ribonucleoprotein granules in the Drosophila #germline. @embl https://www.nature.com/articles/s41556-024-01519-3 https://www.nature.com/articles/s41556-024-01519-3" [X Link](https://x.com/NatureCellBio/status/1841768420917846400) 2024-10-03T09:13Z 124.3K followers, [----] engagements "💫NEW by @toettch @h4rrymcnamara & co: synthetic signal-recording gene circuits on mouse #gastruloids show that cell sorting rearranges patchy domains of Wnt activity into a single pole that defines the anteriorposterior axis. https://www.nature.com/articles/s41556-024-01521-9 https://rdcu.be/dVTQc https://www.nature.com/articles/s41556-024-01521-9 https://rdcu.be/dVTQc" [X Link](https://x.com/NatureCellBio/status/1841818231683874848) 2024-10-03T12:31Z 125.6K followers, [----] engagements "💫NEW: @fran_bottanelli @A_STEDhammer @petiaadarska & co describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-#Golgi sorting. @fubcp @FU_Berlin https://www.nature.com/articles/s41556-024-01518-4 https://www.nature.com/articles/s41556-024-01518-4" [X Link](https://x.com/NatureCellBio/status/1844720857509433558) 2024-10-11T12:45Z 125.6K followers, [----] engagements Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing
@NatureCellBio Nature Cell Biology
Nature Cell Biology posts on X about cell, study, article, stem the most. They currently have [-------] followers and [---] posts still getting attention that total [-----] engagements in the last [--] hours.
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Social Influence
Social category influence technology brands currencies finance ncaa basketball nfts cryptocurrencies travel destinations
Social topic influence cell, study, article, stem, in the, membrane, mitosis, human, vivo, growth
Top accounts mentioned or mentioned by @zakbakes @pagliarinilab @sloanlab @caitlinsojka @brumbaughjb @jingtaoguo @leqianyu @szmydradoslaw @thecesarelab @radoncdocgee @scientistjoanna @ruggerodavide @natcellbionaturecom @demetriadeslab @cuilabchem @stanforduchem @stanfordchemh @bianxiaoc @eddagschulz @filipovskalab
Top assets mentioned Enzyme (MLN) Luminal Universe (luminal-universe) Flux (FLUX) Synapse (SYN)
Top Social Posts
Top posts by engagements in the last [--] hours
"Ectosomes step forward in -synuclein spread Nature Cell Biology Glucosylceramide accumulation — a hallmark of GBA1- and LRRK2-linked Parkinson’s disease — drives ectosome shedding from neurons. A study now shows that these plasma membrane-derived vesicles shuttle pathogenic α-synuclein across cells revealing ectosomes as an underappreciated route of pathology propagation in Parkinson’s disease"
X Link 2026-02-14T17:20Z 122.8K followers, [----] engagements
"Ex vivo imaging reveals the spatiotemporal control of ovulation Nature Cell Biology Thomas Marx et al. devise a live imaging approach to spatiotemporally dissect mouse ovulation ex vivo"
X Link 2024-12-04T15:00Z 2.1M followers, 163.3K engagements
"Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling Nature Cell Biology Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation leading to YAP/TAZ activation"
X Link 2026-01-24T13:14Z 2.1M followers, [----] engagements
"💫NEW: Visvader Lindeman & co identify #luminal progenitors as likely cells-of-origin in #BRCA2-#BreastCancer exhibiting dysregulated #proteostasis and translation which may be therapeutically targeted via mTORC1 inhibition. https://www.nature.com/articles/s41556-023-01315-5 https://rdcu.be/dvVAa https://www.nature.com/articles/s41556-023-01315-5 https://rdcu.be/dvVAa"
X Link 2024-01-13T21:25Z 122.8K followers, 14.7K engagements
"Triacylglycerol mobilization underpins mitochondrial stress recovery Nature Cell Biology Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis"
X Link 2025-02-17T14:48Z 2.1M followers, [----] engagements
"Nuclear speckles regulate functional programs in cancer Nature Cell Biology This study reports that nuclear speckle constituents have two expression states in cancer correlating with patient survival and HIF-2α functional programs. HIF-2α mediates nuclear speckle association of key genes activated in renal cancer"
X Link 2025-01-13T13:38Z 2.1M followers, [----] engagements
"The transcription factor GABPA is a master regulator of naive pluripotency Nature Cell Biology Zhang and colleagues identify the transcription factor GABPA as a regulator of zygotic genome activation epiblast formation and naive pluripotency establishment"
X Link 2025-01-10T12:56Z 2.1M followers, [----] engagements
"Precursor occupancy controls mitochondrial import channel via proteolysis Nature Cell Biology Blocking the translocase of the outer membrane (TOM) channel induces elimination of unoccupied protein import channels in the inner membrane by an ATP-dependent protease. Precursor-dependent adjustment of the number of translocator channels provides new insights into mitochondrial quality control upon protein import stress"
X Link 2025-02-16T18:53Z 2.1M followers, [----] engagements
"AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress Nature Cell Biology Zhai Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during tumour growth"
X Link 2025-01-31T13:27Z 2.1M followers, [----] engagements
"Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations Nature Cell Biology Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaining a robust redox ratio is key to clonal prevalence"
X Link 2025-02-16T18:41Z 2.1M followers, [----] engagements
"H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium Nature Cell Biology Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment whereas its suppression which is also observed upon injury induces a plastic state and expression of genes involved in regeneration"
X Link 2025-02-19T21:35Z 2.1M followers, [----] engagements
"A nucleolar mechanism suppresses organismal proteostasis by modulating TGF/ERK signalling Nature Cell Biology Zhu et al. show that disabling the nucleolar FIB-1NOL-56 complex protects Caenorhabditis elegans from the toxicity of neurodegeneration-linked protein aggregates across tissues by modulating TGFβ signalling and enhancing proteasome activity"
X Link 2025-02-16T18:38Z 2.1M followers, [----] engagements
"Speckle signatures dictate cancer prognosis Nature Cell Biology Nuclear speckles are dynamic structures enriched in RNA and RNA regulators with varying compositions. A study now reports two distinct signatures of nuclear speckles that are linked to the prognosis of clear cell renal cell carcinoma. The signatures influence the expression of genes regulated by the transcription factor HIF2α"
X Link 2025-01-13T13:38Z 2.1M followers, [----] engagements
"Mitochondrial YME1L1 governs unoccupied protein translocase channels Nature Cell Biology Hsu et al. show that mitochondrial import blockage stress activates the ATP-dependent protease YME1L1 which degrades mitochondrial presequence translocase TIM23 subunits to promote cell growth"
X Link 2025-02-16T18:53Z 2.1M followers, [----] engagements
"Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma Nature Cell Biology Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with aberrant development in glioblastoma"
X Link 2025-02-19T21:31Z 2.1M followers, [----] engagements
"Misshapen chromosomes in check by mechanics Nature Cell Biology Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies"
X Link 2025-02-17T13:55Z 2.1M followers, [----] engagements
"Innate immune sensing of cell death in disease and therapeutics Nature Cell Biology Man and Kanneganti discuss how pattern-recognition sensors in innate immune cells recognize and respond to cell-death signatures and highlight molecular targets for potential therapeutic development"
X Link 2024-12-23T17:01Z 2.1M followers, [----] engagements
"Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint Nature Cell Biology Hervé Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension"
X Link 2025-02-17T13:55Z 2.1M followers, [----] engagements
"Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts Nature Cell Biology Luo et al. show in zebrafish and mouse that upon intrahepatic biliary duct damage gallbladder smooth muscle cells migrate to the common hepatic duct where they produce retinoic acid to promote regeneration of the intrahepatic biliary duct"
X Link 2025-02-17T13:51Z 2.1M followers, [----] engagements
"Multiomics reveals that triacylglycerol mobilization helps drive recovery from mitochondrial stress Nature Cell Biology We devised a multiomics strategy to identify metabolic pathways used by yeast to surmount mitochondrial stress. Strains capable of recovery relied on triacylglycerol mobilization to provide acyl groups for nascent cardiolipin biosynthesis during mitochondrial biogenesis. We further linked multiple proteins to this mobilization phenotype including essential lipases in both yeast and mammalian model systems"
X Link 2025-02-17T14:48Z 2.1M followers, [----] engagements
"The enhancer module of Integrator controls cell identity and early neural fate commitment Nature Cell Biology Zhang et al. report that INST10 part of the Integrator enhancer module promotes epigenetic changes and transcription factor binding at enhancers that drive neural cell fate commitment by stabilizing SOX2 binding at chromatin upon pluripotency exit"
X Link 2024-12-15T23:54Z 2.1M followers, [----] engagements
"Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity Nature Cell Biology Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane thereby regulating body temperature glucose homeostasis and body weight in obese mice"
X Link 2025-01-31T13:39Z 2.1M followers, [----] engagements
"Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy Nature Cell Biology Licheva Pflaum Babic Mancilla et al. show that low-affinity cargoreceptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation"
X Link 2025-01-07T12:49Z 2.1M followers, [----] engagements
"TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling Nature Cell Biology Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair chromosomal instability and whole-genome doubling with distinct mechanisms"
X Link 2025-01-01T19:26Z 2.1M followers, [----] engagements
"Mitochondria and cell death Nature Cell Biology Several processes of regulated cell death engage or use mitochondria which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial outer membrane permeabilization"
X Link 2024-12-29T18:50Z 2.1M followers, 17.3K engagements
"💫NEW: @Gardinilab & co show that INST10 (Integrator subunit) promotes #epigenetic changes and transcription factor binding at enhancers driving #neural fate by stabilizing SOX2 binding at #chromatin upon #pluripotency exit. https://www.nature.com/articles/s41556-024-01556-y https://rdcu.be/d3EWd https://www.nature.com/articles/s41556-024-01556-y https://rdcu.be/d3EWd"
X Link 2024-12-15T23:54Z 122.8K followers, [----] engagements
"☕In this year's #CellDeath focus: Man & Kanneganti reviewed how pattern-recognition sensors in #ImmuneCells recognize and respond to cell-death signatures & highlighted molecular targets for potential therapeutic development. https://www.nature.com/articles/s41556-024-01491-y https://rdcu.be/d4uDO https://www.nature.com/articles/s41556-024-01491-y https://rdcu.be/d4uDO"
X Link 2024-12-23T17:01Z 122.8K followers, [----] engagements
"☕This year in our #CellDeath focus: Kaiwen W. Chen & Petr Broz reviewed recent work highlighting the regulation of gasdermins and emerging biological roles including in non-lethal pore formation and host defence. #pyroptosis https://www.nature.com/articles/s41556-024-01474-z https://rdcu.be/d4BME https://www.nature.com/articles/s41556-024-01474-z https://rdcu.be/d4BME"
X Link 2024-12-28T20:18Z 122.8K followers, [----] engagements
"☕This year in our #CellDeath focus: Glover Schreiner Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis https://www.nature.com/articles/s41556-024-01429-4 https://rdcu.be/d46gt https://www.nature.com/articles/s41556-024-01429-4 https://rdcu.be/d46gt"
X Link 2024-12-29T18:50Z 122.8K followers, 17.3K engagements
"☕This year in our #CellDeath focus: Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis which could be exploited to treat #cancer. https://www.nature.com/articles/s41556-024-01425-8 https://rdcu.be/d493Q https://www.nature.com/articles/s41556-024-01425-8 https://rdcu.be/d493Q"
X Link 2024-12-30T19:38Z 122.8K followers, [----] engagements
"☕This year Granath-Panelo and Kajimura reviewed evidence of #mitochondria heterogeneity in different contexts and discussed how mitochondrial malleability contributes to cell fate determination and tissue remodeling. https://www.nature.com/articles/s41556-024-01410-1 https://rdcu.be/d5gHT https://www.nature.com/articles/s41556-024-01410-1 https://rdcu.be/d5gHT"
X Link 2024-12-31T15:53Z 122.8K followers, [----] engagements
"💫NEW by @Wtlu3 @CharlesSwanton @nnennayaKanu @bartek_Lab & co: analyses of data from the TRACERx cohort of #LungCancer patients delineate how FAT1 regulates HR repair chromosomal instability & whole-genome doubling with distinct mechanisms. @thecrick https://www.nature.com/articles/s41556-024-01558-w https://www.nature.com/articles/s41556-024-01558-w"
X Link 2025-01-01T19:26Z 122.8K followers, [----] engagements
"💫NEW: Zhang & co identify the transcription factor GABPA as a regulator of #ZygoticGenomeActivation #epiblast formation and naive #pluripotency establishment. https://www.nature.com/articles/s41556-024-01554-0 https://www.nature.com/articles/s41556-024-01554-0"
X Link 2025-01-10T12:56Z 122.8K followers, [----] engagements
"💫NEW by @berger_lab & co: #NuclearSpeckle (NS) constituents have [--] expression states in #cancer correlating with patient survival & HIF-2 functional programs. HIF-2 mediates NS association of key genes activated in renal cancer. https://www.nature.com/articles/s41556-024-01570-0 https://rdcu.be/d56c7 https://www.nature.com/articles/s41556-024-01570-0 https://rdcu.be/d56c7"
X Link 2025-01-13T13:38Z 122.8K followers, [----] engagements
"🧁Interested in reading more about the study Here's the N&Vs article written by Hiro Takakuwa & Tetsuro Hirose. https://www.nature.com/articles/s41556-024-01569-7 https://rdcu.be/d56d1 https://www.nature.com/articles/s41556-024-01569-7 https://rdcu.be/d56d1"
X Link 2025-01-13T13:38Z 122.8K followers, [----] engagements
"👋🏿Happy new year and our first [----] issue's out Cover: #chromosomal instability in #cancer 👉Review on #TranscriptionFactors and #cell quiescence 🔬#heterochromatin #embryo #DNArepair #pluripotency #proteostasis #obesity #CellCycle #CellDeath & more https://www.nature.com/ncb/volumes/27/issues/1 https://www.nature.com/ncb/volumes/27/issues/1"
X Link 2025-01-17T13:33Z 122.8K followers, 13.1K engagements
"💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth. https://www.nature.com/articles/s41556-024-01549-x https://rdcu.be/d8apH https://www.nature.com/articles/s41556-024-01549-x https://rdcu.be/d8apH"
X Link 2025-01-31T13:27Z 122.8K followers, [----] engagements
"💫NEW by @puigserver_lab & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane regulating body temperature glucose homeostasis and body weight in #obese mice. https://www.nature.com/articles/s41556-024-01555-z https://rdcu.be/d8atv https://www.nature.com/articles/s41556-024-01555-z https://rdcu.be/d8atv"
X Link 2025-01-31T13:39Z 122.8K followers, [----] engagements
"👋Our February issue's out Cover: #glioblastoma 👉🏼Review on #mitochondria #ProteinImport 👉🏻Viewpoint on #LipidMetabolism 🔬 #HumanEmbryos #NuclearSpeckles #PhaseSeparation #autophagy #mitosis #pluripotency #hematopoiesis #LipidDroplets & more https://www.nature.com/ncb/volumes/27/issues/2 https://www.nature.com/ncb/volumes/27/issues/2"
X Link 2025-02-14T13:49Z 122.8K followers, [----] engagements
"💫NEW: Zhu et al. show that disabling the nucleolar FIB-1NOL-56 complex protects C. elegans from neurodegeneration-linked protein aggregate TOXOCITY across tissues by modulating TGF signaling and enhancing proteasome activity. https://www.nature.com/articles/s41556-024-01564-y https://rdcu.be/d959J https://www.nature.com/articles/s41556-024-01564-y https://rdcu.be/d959J"
X Link 2025-02-16T18:38Z 122.8K followers, [----] engagements
"💫NEW: @AnuHemalatha @valentatormenta @RachelPerryLab1 & co track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin and find that maintaining a robust redox ratio is key to clonal prevalence. https://www.nature.com/articles/s41556-024-01574-w https://www.nature.com/articles/s41556-024-01574-w"
X Link 2025-02-16T18:41Z 122.8K followers, [----] engagements
"💫NEW: @KraftLabFR @WilflingLab & co show that low-affinity cargoreceptor interactions promote #autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation. https://www.nature.com/articles/s41556-024-01572-y https://www.nature.com/articles/s41556-024-01572-y"
X Link 2025-02-16T18:48Z 122.8K followers, [----] engagements
"💫NEW: Hsu et al. show that #mitochondria import blockage stress activates the ATP-dependent protease YME1L1 which degrades mitochondrial presequence translocase TIM23 subunits to promote cell growth. https://www.nature.com/articles/s41556-024-01571-z https://rdcu.be/d96cS https://www.nature.com/articles/s41556-024-01571-z https://rdcu.be/d96cS"
X Link 2025-02-16T18:53Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here's the Research Briefing https://www.nature.com/articles/s41556-024-01575-9 https://rdcu.be/d96dg https://www.nature.com/articles/s41556-024-01575-9 https://rdcu.be/d96dg"
X Link 2025-02-16T18:53Z 122.8K followers, [----] engagements
"💫NEW: Luo & co show in zebrafish and mouse that upon intrahepatic biliary duct damage gallbladder smooth muscle cells migrate to the common hepatic duct where they promote regeneration of the intrahepatic biliary duct. https://www.nature.com/articles/s41556-024-01568-8 https://rdcu.be/eacNY https://www.nature.com/articles/s41556-024-01568-8 https://rdcu.be/eacNY"
X Link 2025-02-17T13:51Z 122.8K followers, [----] engagements
"💫NEW: Herv Scelfo et al. show that #chromosome missegregation induces #mTORC2 - & ATR-mediated p53 activation via a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension. https://www.nature.com/articles/s41556-024-01565-x https://www.nature.com/articles/s41556-024-01565-x"
X Link 2025-02-17T13:55Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here's the N&Vs article written by Joana C. Macedo Maria M. da Silva & Elsa Logarinho. https://www.nature.com/articles/s41556-024-01573-x https://rdcu.be/eacQv https://www.nature.com/articles/s41556-024-01573-x https://rdcu.be/eacQv"
X Link 2025-02-17T13:55Z 122.8K followers, [----] engagements
"💫NEW: @Zak_Bakes @Pagliarini_Lab & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis. https://www.nature.com/articles/s41556-024-01586-6 https://www.nature.com/articles/s41556-024-01586-6"
X Link 2025-02-17T14:48Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here's the Research Briefing: https://www.nature.com/articles/s41556-024-01603-8 https://rdcu.be/eadgo https://www.nature.com/articles/s41556-024-01603-8 https://rdcu.be/eadgo"
X Link 2025-02-17T14:48Z 122.8K followers, [----] engagements
"💫NEW: @Sloan_Lab @CaitlinSojka & co analyse the transcriptomic & epigenomic landscape of human #astrocyte maturation and identify an epigenetically regulated intermediate state linked with aberrant development in #glioblastoma. https://www.nature.com/articles/s41556-024-01583-9 https://rdcu.be/eayMF https://www.nature.com/articles/s41556-024-01583-9 https://rdcu.be/eayMF"
X Link 2025-02-19T21:31Z 122.8K followers, [----] engagements
"💫NEW: @Brumbaugh_JB Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment whereas its suppression induces a plastic state and expression of genes involved in #regeneration. https://www.nature.com/articles/s41556-024-01580-y https://rdcu.be/eayN3 https://www.nature.com/articles/s41556-024-01580-y https://rdcu.be/eayN3"
X Link 2025-02-19T21:35Z 122.8K followers, [----] engagements
"☕Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human #pluripotent stem cells by interacting with #NuclearMatrix protein Matrin-3 and regulating primed-specific genes. http://bit.ly/4kfVwT8 https://rdcu.be/ebq0W http://bit.ly/4kfVwT8 https://rdcu.be/ebq0W"
X Link 2025-02-26T21:11Z 122.8K followers, [----] engagements
"☕Fulcher et al. show that #MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction triggering G1 arrest following delays in #mitosis associated with chromosome instability and #aneuploidy. https://bit.ly/3EUEc66 https://bit.ly/3EUEc66"
X Link 2025-02-26T21:16Z 122.8K followers, [----] engagements
"☕@JingtaoGuo @LeqianYu & co characterize an intact Carnegie stage [--] #HumanEmbryo at single-cell resolution in a spatially resolved manner. https://bit.ly/3XhKW48 https://rdcu.be/ebq3Q https://bit.ly/3XhKW48 https://rdcu.be/ebq3Q"
X Link 2025-02-26T21:24Z 122.8K followers, [----] engagements
"☕@szmyd_radoslaw @TheCesareLab @RadOncDoc_Gee & co: #DNArepair pathways impact if cells with DNA lesions arrest in mitosis. Homologous recombination-driven double Holliday junction formation elicits mitotic #CellDeath & suppresses inflammatory signaling. https://bit.ly/4bfssHr https://bit.ly/4bfssHr"
X Link 2025-02-26T21:35Z 122.8K followers, [----] engagements
"🍰Read also the N&Vs article. https://bit.ly/4bk4ScD https://rdcu.be/ebq9N https://bit.ly/4bk4ScD https://rdcu.be/ebq9N"
X Link 2025-02-26T21:35Z 122.8K followers, [----] engagements
"☕Interested in how cells respond to #mitochondria #ProteinImport stress Read our Review article by Nikolaus Pfanner Fabian den Brave & Thomas Becker. https://bit.ly/41oGhyD https://rdcu.be/ecb3x https://bit.ly/41oGhyD https://rdcu.be/ecb3x"
X Link 2025-03-04T22:27Z 122.8K followers, [----] engagements
"☕Afonso et al. show that during #anaphase chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size slowing in smaller cells thereby scaling anaphase. https://bit.ly/4bpoMCU https://bit.ly/4bpoMCU"
X Link 2025-03-04T22:35Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here is the N&Vs article written by Nicoletta I. Petridou. https://bit.ly/4kniCrb https://rdcu.be/ecb3M https://bit.ly/4kniCrb https://rdcu.be/ecb3M"
X Link 2025-03-04T22:35Z 122.8K followers, [----] engagements
"☕Wang et al. profile the #translatome of #hematopoietic #StemCells (HSCs) and downstream progenitors and lineages. They identify the SNORD113114 cluster as a modulator of translation and self-renewal in HSCs. https://bit.ly/4i2xxVX https://rdcu.be/ecb3W https://bit.ly/4i2xxVX https://rdcu.be/ecb3W"
X Link 2025-03-04T22:41Z 122.8K followers, [----] engagements
"Glucosylceramide-induced ectosomes propagate pathogenic -synuclein in Parkinsons disease Nature Cell Biology Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein with relevance to Parkinson’s disease pathology"
X Link 2026-02-12T17:26Z 2.1M followers, [----] engagements
"Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis Nature Cell Biology This Review presents the metabolic landscape of HSCs including the link of key metabolic features to self-renewal and differentiation and highlights how their alterations contribute to haematological disorders particularly leukaemogenesis"
X Link 2026-02-11T11:26Z 2.1M followers, [----] engagements
"☕Oborsk-Oplov et al. report a conserved #mitochondria avoidance segment in the cytosolic ribosomal protein uS5 that prevents mistargeting of uS5 to the mitochondrial matrix and ensures cytosolic #ribosomal assembly. https://bit.ly/3EZV8bi https://rdcu.be/ecb32 https://bit.ly/3EZV8bi https://rdcu.be/ecb32"
X Link 2025-03-04T22:48Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here is the N&Vs article written by Kanda M. Borgognoni & Robin E. Stanley. https://bit.ly/4iq3iYV https://rdcu.be/ecb4a https://bit.ly/4iq3iYV https://rdcu.be/ecb4a"
X Link 2025-03-04T22:48Z 122.8K followers, [----] engagements
"☕@ScientistJoanna @RuggeroDavide & co perform a genome-wide CRISPRi screen and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth. https://bit.ly/41rGfGb https://rdcu.be/ecb4e https://bit.ly/41rGfGb https://rdcu.be/ecb4e"
X Link 2025-03-04T22:57Z 122.8K followers, [----] engagements
"🍰Interested in reading more about the study Here is the N&Vs article written by Zainab Hussain & Mara H. Sherman. https://bit.ly/4knA1js https://rdcu.be/ecb4q https://bit.ly/4knA1js https://rdcu.be/ecb4q"
X Link 2025-03-04T22:57Z 122.8K followers, [----] engagements
"👋🏽A reminder to all our authors and readers that you can now find us and connect with us on Bluesky: @natcellbio.nature.com #Science #CellBiology #ScienceCommunication"
X Link 2025-06-20T22:43Z 122.8K followers, 14.1K engagements
"FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation thereby preventing the induction of ferroptosis"
X Link 2025-10-29T15:17Z 228.6M followers, 20.3K engagements
"Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier Nature Cell Biology Kozai Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shapes barrier dynamics and disorder within the pore"
X Link 2025-12-02T10:05Z 228.6M followers, [--] engagements
"Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration Nature Cell Biology Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquitylation and promoting mitochondrial respiration"
X Link 2025-11-01T06:28Z 228.6M followers, [----] engagements
"In vivo models bring FSP1 inhibitors to life Nature Cell Biology FSP1 is a key suppressor of lipid peroxidation and ferroptosis yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in vivo establishing it as a context-specific cancer vulnerability and highlighting the therapeutic potential of FSP1 inhibition"
X Link 2025-12-12T16:13Z 228.6M followers, [----] engagements
"The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to heterochromatin detachment and derepression of gene and transposon expression"
X Link 2025-08-02T02:11Z 208.1M followers, [--] engagements
"Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS Nature Cell Biology Wang et al. identify ZNFX1 as a mitochondria-localised sensor that recognizes viral dsRNA and induces a type I interferon response thereby restricting virus infection"
X Link 2019-11-15T06:59Z 208.1M followers, [--] engagements
"Inheriting chromosome conformation Nature Cell Biology Chromosomes unfold and refold each time cells divide. A study by Schooley et al. demonstrates that chromosome-intrinsic and cytoplasmic factors uniquely contribute to interphase chromosome structure with new possibilities for how gene expression programs are passed from mother cells to daughter cells"
X Link 2025-12-23T02:57Z 228.6M followers, [---] engagements
"The multifaceted contributions of mitochondria to cellular metabolism Nature Cell Biology Nature Cell Biology - The multifaceted contributions of mitochondria to cellular metabolism"
X Link 2025-11-10T14:36Z 228.6M followers, [--] engagements
"Spermidine is essential for fasting-mediated autophagy and longevity Nature Cell Biology Hofer et al. show that fasting promotes the synthesis of spermidine which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner"
X Link 2025-12-29T15:13Z 2.1M followers, 801.9K engagements
"Modelling co-development between the somites and neural tube in human trunk-like structures Nature Cell Biology Makwana Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage [----] of development. They use them to model and study the development of the thoracic and lumbar trunk"
X Link 2025-12-16T12:10Z 228.6M followers, 10.2K engagements
"CoCo-ST detects global and local biological structures in spatial transcriptomics datasets Nature Cell Biology Wu Zhang and colleagues introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST) a graph contrastive learning-based method for spatial transcriptomics analysis that detects low-variance structures"
X Link 2025-10-17T15:32Z 208.1M followers, [----] engagements
"dCas9-based gene editing for cleavage-free genomic knock-in of long sequences Nature Cell Biology Wang Qu et al. developed a genome-editing system utilizing catalytically inactive Cas9 fused to microbial single-strand annealing proteins for kilobase-scale insertion in human cells without introducing DNA nicks or breaks"
X Link 2026-01-21T03:46Z 2.1M followers, [--] engagements
"T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response Nature Cell Biology Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity level and is T follicular helper cell-dependent"
X Link 2025-12-30T14:38Z 228.6M followers, [----] engagements
"Decoding the proton veil around lysosomes Nature Cell Biology A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen identifying a nanoscale regulatory interface that links luminal pH TMEM175-mediated proton efflux organelle positioning and neurodegeneration"
X Link 2026-01-26T13:41Z 2.1M followers, [----] engagements
"Championing scientist migration Nature Cell Biology Science thrives on the free exchange of ideas and collaboration between diverse groups with researcher mobility greatly accelerating progress. With isolationist rhetoric increasingly dominating the political discourse in many countries it is important to recognize the value of migration in science"
X Link 2019-02-05T10:37Z 208.1M followers, [--] engagements
"Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm Nature Cell Biology Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm"
X Link 2025-12-23T02:57Z 228.6M followers, [---] engagements
"Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma Nature Cell Biology Mohri et al. show that in response to genotoxic stress melanocyte stem cells undergo senescence-associated differentiation causing their depletion and protecting them against melanomagenesis. This process is suppressed by carcinogens"
X Link 2025-10-21T21:26Z 228.6M followers, [----] engagements
"From fallout to renewal Nature Cell Biology In the wake of the atomic bombings of Hiroshima and Nagasaki urgent efforts aimed at understanding radiation sickness catalysed the birth of bone marrow transplantation and stem cell biology. In this historical Comment we highlight the critical role of government support in empowering fundamental studies that can lead often unexpectedly to considerable advances for science and human health"
X Link 2025-12-01T14:09Z 228.6M followers, [----] engagements
"Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein Nature Cell Biology Rajshekar et al. show that a hierarchy of affinities layers pericentromeric heterochromatin around nucleoli with the RNA helicase Pitchoune (DDX18) acting as a key dual-affinity linker in Drosophila melanogaster"
X Link 2025-11-24T21:52Z 228.6M followers, [----] engagements
"DNA nanodevices detect an acidic nanolayer on the lysosomal surface Nature Cell Biology Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH"
X Link 2026-01-21T13:07Z 228.6M followers, [----] engagements
"Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues Nature Cell Biology Yuan et al. present S2-omics an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments"
X Link 2025-12-01T17:52Z 228.6M followers, 15.1K engagements
"Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells Nature Cell Biology della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity"
X Link 2025-11-18T15:51Z 228.6M followers, 26.1K engagements
"PEX39 facilitates the peroxisomal import of PTS2-containing proteins Nature Cell Biology Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins"
X Link 2025-07-31T17:07Z 228.6M followers, [----] engagements
"Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimers disease Nature Cell Biology Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology"
X Link 2025-09-04T14:55Z 208.1M followers, [---] engagements
"💫NEW by Zhang & co: [--] distinct types of #myeloid#Bcell interaction may signal solid tumor-induced immunosuppression and correlate with complete responses to #immunotherapy in #BreastCancer patients. @bcmhouston @BCMCancerCenter https://www.nature.com/articles/s41556-024-01508-6 https://rdcu.be/dVcfx https://www.nature.com/articles/s41556-024-01508-6 https://rdcu.be/dVcfx"
X Link 2024-09-27T01:00Z 123.8K followers, [----] engagements
"Our November issue is now live Cover image: "Controlling EMT in development and metastasis" by Kang and co () http://t.co/MbJtF8AO http://bit.ly/Tuv2eF http://bit.ly/Tuv2eF"
X Link 2012-11-06T13:19Z 123.2K followers, [--] engagements
"Cerebral organoids display dynamic clonal growth and tunable tissue replenishment - Nature Cell Biology Lindenhofer Haendeler Esk Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands"
X Link 2024-05-07T00:00Z 125.1K followers, [----] engagements
"NAD+ regulates nucleotide metabolism and genomic DNA replication Nature Cell Biology Munk et al. show that exogenous NAD+ but not its precursors induces metabolic changes in mitochondria affecting nucleotide metabolism with impacts on genomic DNA synthesis and genome integrity"
X Link 2025-10-18T03:15Z 208.1M followers, [---] engagements
"To eat or not to eat - Nature Cell Biology Nature Cell Biology - To eat or not to eat"
X Link 2024-11-11T00:00Z 125.3K followers, [----] engagements
"RNAs kiss and translate in germ granules Nature Cell Biology The assembly of germ granules remains unknown but recent attention to the role of RNA structure in membrane-less organelle assembly is changing our understanding of RNAs in the cell. Two studies now show how RNARNA interactions drive germ granule assembly and how germ granules spatially regulate embryonic mRNA translation"
X Link 2024-10-04T17:06Z 208.1M followers, [---] engagements
"Spatial and functional separation of mTORC1 signalling in response to different amino acid sources - Nature Cell Biology Fernandes Angelidaki et al. provide evidence supporting the spatial separation of mTORC1 activation and signalling. Differentially localized mTORC1 complexes phosphorylate distinct substrates in response to different amino acid supplies"
X Link 2024-10-09T00:00Z 208.1M followers, [----] engagements
"Deciphering glioma susceptibility Nature Cell Biology The regulatory mechanisms that drive oncogene expression in gliomas remain poorly understood. A study now identifies a role for widespread rearrangements of the enhancer connectome. Such rearrangements are linked to known genetic risk variants revealing how genetic predisposition contributes to malignancy"
X Link 2025-10-15T01:54Z 208.1M followers, [--] engagements
"The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity - Nature Cell Biology Hockemeyer et al. demonstrate that HSF1 activation inhibits cytokine production and cytotoxic activity in NK cells to impair anti-tumour immune responses"
X Link 2024-09-02T00:00Z 125K followers, [----] engagements
"Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks Nature Cell Biology Saur Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes independently of de novo recruitment of RNA polymerase II/III as a result of DSB-induced transcriptional repression"
X Link 2025-08-05T20:18Z 208.1M followers, [---] engagements
"Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition - Nature Cell Biology Schwab Rao et al. report that Zeb1 mediates enhanced ferroptosis sensitivity in cancer cells after EMT activation associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio"
X Link 2024-07-15T00:00Z 125.6K followers, [----] engagements
"Forcing cell fate Nature Cell Biology The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces long considered background players in guiding this transition are essential regulators of chromatin accessibility and cell fate decisions"
X Link 2025-09-30T19:16Z 208.1M followers, [--] engagements
"An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory Nature Cell Biology Lanna and colleagues discover extracellular vesicle-mediated transfer of telomeres from antigen-presenting cells to T cells which enables elongation of chromosomes protection against replicative senescence and long-term immune defence"
X Link 2022-10-11T08:03Z 2.1M followers, 70.2K engagements
"Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation - Nature Cell Biology Bernab-Rubio et al. report that dedifferentiation of Gata6+ epidermal cells occurs during wound healing or mechanical expansion of the epidermis through a Myc-dependent process that resembles reversal of differentiation"
X Link 2023-09-21T00:00Z 125.6K followers, [----] engagements
"Keeping membraneless organelles apart - Nature Cell Biology How spatial organization in the cell is achieved on the organelle scale is unclear. A new study finds that tethering specific proteins near the surface of micelle-like paraspeckles modifies their properties and determines whether these subnuclear organelles are separate from adhere to or are engulfed by nuclear speckles"
X Link 2023-11-06T00:00Z 125K followers, [----] engagements
"Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer Nature Cell Biology Al-Hilal Chrysovergi et al. identify a role for durotaxis in lung fibrosis and metastatic pancreatic cancer mediated by the FAKpaxillin mechanosensor complex and demonstrate therapeutic targeting of this pathway using the small molecule JP-153"
X Link 2025-09-16T20:35Z 208.1M followers, [----] engagements
"Noncanonical inheritance of phenotypic information by protein amyloids - Nature Cell Biology Eroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein loss results in a transgenerational feminization phenotype through ectopic GLD-1 expression"
X Link 2024-09-02T00:00Z 208.1M followers, 212.4K engagements
"Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment Nature Cell Biology Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy"
X Link 2023-12-20T19:16Z 228.6M followers, [---] engagements
"An architectural role of specific RNARNA interactions in oskar granules - Nature Cell Biology Bose Rankovic et al. show that a specific RNARNA kissing-loop interaction plays a crucial role in driving biomolecular condensation of ribonucleoprotein granules in the Drosophila germline"
X Link 2024-10-01T00:00Z 208.1M followers, 25.5K engagements
"LIANA+ provides an all-in-one framework for cellcell communication inference - Nature Cell Biology Dimitrov et al. present LIANA+ a framework that unifies and extends approaches to study inter- and intracellular signalling from diverse mediators captured from single-cell spatially resolved and multi-omics data"
X Link 2024-09-02T00:00Z 125.6K followers, 29K engagements
"EPAC1 enhances brown fat growth and beige adipogenesis Nature Cell Biology Reverte-Salisa et al. show that in preadipocytes EPAC1 enhances brown adipose tissue growth and increases the function of thermogenic fat in obesogenic conditions. Activation of EPAC1 induces human brown adipocyte proliferation and differentiation"
X Link 2024-03-06T17:30Z 208.1M followers, [---] engagements
"H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos - Nature Cell Biology Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition following H2AK119 mono-ubiquitylation deposition. It is also required for the subsequent H3K27me3 deposition at the blastocyst stage"
X Link 2024-10-31T00:00Z 125.3K followers, 41.1K engagements
"Gasdermins as evolutionarily conserved executors of inflammation and cell death - Nature Cell Biology Gasdermins are a family of proteins that form membrane pores and elicit pyroptosis. This Review discusses recent work highlighting their regulation and emerging biological roles including in non-lethal pore formation and host defence"
X Link 2024-08-26T00:00Z 2.1M followers, [----] engagements
"Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth - Nature Cell Biology Guo Hong et al. report that TET2 condensation maintains proper DNA demethylation at specific genomic loci which can be targeted to alter gene expression and impair leukaemia growth"
X Link 2024-09-09T00:00Z 125.6K followers, 12.2K engagements
"Solid tumour-induced systemic immunosuppression involves dichotomous myeloidB cell interactions Nature Cell Biology Hao Shen and colleagues identify and characterize two distinct types of myeloidB cell interaction that may signal solid tumour-induced immunosuppression and can correlate with complete responses to immunotherapy in patients with breast cancer"
X Link 2024-09-27T01:00Z 228.6M followers, [----] engagements
"ARF1 compartments direct cargo flow via maturation into recycling endosomes - Nature Cell Biology Stockhammer Adarska et al. describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-Golgi sorting. Shedding of ARF1 and maturation into recycling endosomes drives sorting of secretory and endocytic recycling cargo"
X Link 2024-10-04T00:00Z 125.4K followers, 18.3K engagements
"HSF1 renders NK cells too stressed to respond - Nature Cell Biology The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells the HSF1 transcription factor binds to mediators of effector function negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy"
X Link 2024-09-02T00:00Z 125.6K followers, [--] engagements
"Spatiotemporal coordination of actin regulators generates invasive protrusions in cellcell fusion - Nature Cell Biology Lu et al. reveal the spatiotemporal coordination between two nucleation-promoting factors WAVE and N-WASP and two actin-bundling proteins dynamin and WIP in generating invasive protrusions at the mammalian myoblast fusogenic synapse"
X Link 2024-11-01T00:00Z 125.3K followers, [----] engagements
"Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover - Nature Cell Biology Aeby et al. report that DCP1A negatively regulates Tsix RNA abundance by suppressing its transcriptional elongation and RNA stability thus contributing to X-chromosome inactivation"
X Link 2020-08-17T00:00Z 125.6K followers, [--] engagements
"p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells - Nature Cell Biology Majewska et al. show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1 by downregulating its proteasome-mediated ubiquitin-dependent degradation leading to their accumulation in ageing and chronic inflammation"
X Link 2024-08-05T00:00Z 125.6K followers, [--] engagements
"Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart Nature Cell Biology Dardano et al. generate human pluripotent stem cell-derived cardiac organoids capable of undergoing endothelial-to-haematopoietic transition and producing haematopoietic cells"
X Link 2024-10-17T06:00Z 124.5K followers, [----] engagements
"Docking a flexible basket onto the core of the nuclear pore complex - Nature Cell Biology Stankunas and Khler define how the nucleoplasmic portion of the nuclear pore complex (NPC) the basket docks onto the NPC core by integrating AlphaFold-based interaction screens electron microscopy and membrane-templated reconstitutions"
X Link 2024-08-13T00:00Z 125.6K followers, [--] engagements
"Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells Nature Cell Biology McCreery Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes"
X Link 2025-09-30T19:18Z 121.8K followers, [--] engagements
"Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor - Nature Cell Biology Nicastro Brohe et al. find that the fatty acid synthesis intermediate malonyl-CoA inhibits mTORC1 showing mTORC1 senses the capacity of a cell to synthesise fatty acids and linking fatty acid generation with the overall biosynthetic output through mTORC1"
X Link 2023-08-10T00:00Z 125.6K followers, 11.2K engagements
"On the causal role of retromer-dependent endosomal recycling in Alzheimers disease - Nature Cell Biology Recent findings ranging from genetics to structural biology together with studies in human neurons animal models and patient brains implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimers disease"
X Link 2023-10-06T00:00Z 125.5K followers, [----] engagements
"Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferroptosis which could be exploited to treat cancers"
X Link 2024-06-10T00:00Z 2.1M followers, [----] engagements
"Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGF and Hippo signalling to drive regeneration - Nature Cell Biology Using deep single-nucleus multi-omics profiling Fink et al. report transition states between crypt epithelial cells and a revival stem cell lineage. They find that the TGF and Hippo signalling pathways cooperatively drive intestinal regeneration"
X Link 2024-11-15T00:00Z 125.1K followers, [----] engagements
"A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate Nature Cell Biology Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate"
X Link 2025-09-17T20:32Z 208.1M followers, [----] engagements
"Hepatocellular senescence induces multi-organ senescence and dysfunction via TGF - Nature Cell Biology Kiourtis et al. show that liver senescence triggers senescence and dysfunction in other organs through TGF secretion from the liver"
X Link 2024-11-13T00:00Z 125K followers, 10.7K engagements
"Blebbisomes are large organelle-rich extracellular vesicles with cell-like properties Nature Cell Biology Jeppesen Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles"
X Link 2025-02-22T08:34Z 2.1M followers, 61.8K engagements
"The ETS transcription factor ETV6 constrains the transcriptional activity of EWSFLI to promote Ewing sarcoma - Nature Cell Biology Independent but complementary studies from Vakoc and Stegmaier identify and characterize a role for ETV6 in counteracting the transcriptional activity of EWSFLI during Ewing sarcoma development which may be targeted for therapeutic benefits"
X Link 2023-01-19T00:00Z 208.1M followers, [---] engagements
"An overview of contemporary theories of ageing Nature Cell Biology This Review provides an overview of modern mechanistic theories and critically examines two main groups of ageing theories—error and program based—in the context of ageing patterns genetic manipulations and longevity drugs"
X Link 2025-07-01T09:42Z 2.1M followers, 41.7K engagements
"Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology Zhou et al. describe an intracellular transport pathway of low-density lipoprotein (LDL)LDL receptor from the plasma membrane that bypasses lysosomes and delivers cholesterol to mitochondria for steroidogenesis"
X Link 2023-06-05T00:00Z 125.2K followers, 27.5K engagements
"Emerging connections between myelin and Alzheimers disease Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here we discuss emerging evidence that oligodendrocytes may directly contribute to disease pathology and progression"
X Link 2025-08-01T15:35Z 228.6M followers, [----] engagements
"FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy - Nature Cell Biology van der Weijden et al. perform genomic proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause"
X Link 2024-01-04T00:00Z 125.1K followers, [----] engagements
"Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles - Nature Cell Biology Takakuwa Yamazaki et al. show that the long noncoding RNA NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish nuclear speckles from paraspeckles to preserve their structural identity"
X Link 2023-11-06T00:00Z 125K followers, [----] engagements
"MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death Nature Cell Biology Nguyen Collier et al. find a mitochondrialysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate pyroptosis"
X Link 2025-10-13T17:44Z 228.6M followers, 10.8K engagements
"Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition - Nature Cell Biology Yuzhalin et al. report that astrocyte-mediated upregulation of Cdk5 in metastatic breast cancer cells inhibits MHC-I expression on the cell surface thereby enabling escape from killing by CD8+ T cells and facilitating brain metastasis"
X Link 2024-09-20T00:00Z 125.6K followers, [----] engagements
"FMRP regulates MFF translation to locally direct mitochondrial fission in neurons - Nature Cell Biology Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites where they promote local MFF synthesis and fission at the mitochondrial midzone"
X Link 2024-11-15T00:00Z 125.1K followers, 10.7K engagements
"Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells - Nature Cell Biology Zhang et al. uncover different dynamics underlying the maintenance and regulation of H3K9me3-enriched heterochromatin domains in mouse embryonic stem cells and propose that loss of H3K9me3 occurs through two distinct dynamic modes: passive dilution and active removal"
X Link 2024-10-31T00:00Z 125.1K followers, 10.9K engagements
"Basic science is not just a foundation Nature Cell Biology Intellectual freedom for scientists unconstrained by commercial interests and direct application fuels unexpected discoveries. Curiosity-driven basic science has yielded a deeper understanding of how life forms develop and function in their environment and has had wide implications for health and our planet. Investing in this is vital for scientific progress and is worth protecting in a democracy"
X Link 2024-01-17T12:49Z 208.1M followers, [---] engagements
"Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking - Nature Cell Biology Toettcher McNamara and colleagues use synthetic signal-recording gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt activity into a single pole which defines the gastruloid anteriorposterior axis"
X Link 2024-10-02T00:00Z 125.6K followers, [----] engagements
"Mitochondrial heterogeneity and adaptations to cellular needs - Nature Cell Biology Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling"
X Link 2024-05-16T00:00Z 2.1M followers, [----] engagements
"Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination - Nature Cell Biology Huang Li An Yang Cui et al. perform a single-cell multi-omics analysis of human spermatogenesis and identify a DNA demethylation event upon meiosis initiation which is associated with meiotic recombination"
X Link 2023-09-18T00:00Z 125.5K followers, [----] engagements
"Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Nature Cell Biology Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils"
X Link 2019-07-18T10:12Z 124.5K followers, [--] engagements
"Building the epigenetic fortress with PRC2.2 - Nature Cell Biology How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation which is crucial for gene regulation and lineage specification"
X Link 2024-10-31T00:00Z 125.6K followers, [---] engagements
"Spindle architecture constrains karyotype evolution - Nature Cell Biology Helsen et al. use experimental evolution and chromosome engineering to probe the link between karyotype changes and the cell division machinery. They conclude that spindle organization dictates the available trajectories for karyotype evolution"
X Link 2024-08-08T00:00Z 125.6K followers, [--] engagements
"Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome Nature Cell Biology Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective neuronal physiology and increased seizure susceptibility linking chaperone-mediated autophagy to neuronal excitability"
X Link 2025-10-16T14:38Z 208.1M followers, [---] engagements
"Telomere dysfunction in ageing and age-related diseases Nature Cell Biology Rossiello et al. review the contributions of telomere shortening and/or dysfunction to ageing and a broad spectrum of age-associated human diseases"
X Link 2025-10-11T17:22Z 2.1M followers, 70.4K engagements
"Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum - Nature Cell Biology Yang et al. show that plasma membrane curvature promotes the site-specific formation of contacts with the endoplasmic reticulum through junctophilin-2 tethers in cardiomyocytes"
X Link 2024-09-17T00:00Z 125.6K followers, 18.4K engagements
"Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to anti-osteoporosis treatments"
X Link 2024-11-11T00:00Z 125.2K followers, [----] engagements
"NEW ONLINE: We spoke to Kara McKinley (@karalmckinley) assistant professor of stem cell and regenerative biology at @HSCRB about her career and goals for our research community. Find the Q&A here: https://www.nature.com/articles/s41556-022-01083-8 https://rdcu.be/c4poh https://www.nature.com/articles/s41556-022-01083-8 https://rdcu.be/c4poh"
X Link 2023-01-29T20:52Z 124.5K followers, 62.3K engagements
"☕NEW: Zhou et al. describe an intracellular transport pathway of low-density lipoprotein (LDL)LDL receptor from the plasma membrane that bypasses lysosomes and delivers cholesterol to mitochondria for steroidogenesis. https://www.nature.com/articles/s41556-023-01160-6 https://rdcu.be/demjw https://www.nature.com/articles/s41556-023-01160-6 https://rdcu.be/demjw"
X Link 2023-06-12T20:17Z 125.2K followers, 19.4K engagements
"🧋NEW: Chung et al. identify the Troyer syndrome protein spartin as a #lipophagy receptor for #lipiddroplet clearance in vitro and in vivo. @TobiWalther @BobFarese @FandWLab @JeeyunC @MCB_Harvard @SKI_CellBiology"
X Link 2023-07-19T08:18Z 122.4K followers, 16.9K engagements
"🧋NEW: Nicastro Brohe et al. find that #malonylCoA inhibits #mTORC1 thus linking #fattyacid generation with the overall biosynthetic output through mTORC1. @Raf_Nic @laura_brohee @LabVanni @TelemanLab @CDV1893 @DemetriadesLab https://www.nature.com/articles/s41556-023-01198-6 https://www.nature.com/articles/s41556-023-01198-6"
X Link 2023-08-17T17:42Z 125.6K followers, 11.2K engagements
"🍹NEW: Romanauska and Khler manipulate the levels of endogenously produced saturated acyl chains in yeast and show that #NuclearEnvelope and #NuclearPoreComplex function are uniquely sensitive to #lipid acyl chain unsaturation. @MaxPerutzLabs"
X Link 2023-08-22T12:43Z 121.7K followers, [----] engagements
"🍹NEW: @bernstein_lab & co show that macroH2A deficiency in #CancerAssociatedFibroblasts alters #chromatinlooping and #inflammatory gene expression and limits the #AntiTumor response in #melanoma. @TischCancer @IcahnMountSinai @MelanomaReAlli"
X Link 2023-09-04T16:51Z 121.8K followers, [----] engagements
"🍹NEW: Surani Irie & co show that #DMRT1 induction in #PrimordialGermCell-like cells triggers germline commitment but suppresses #pluripotency genes thus promoting the onset of #gametogenesis. @GurdonInstitute"
X Link 2023-09-21T12:44Z 121.7K followers, [----] engagements
"🍹NEW: Huang Li An Yang Cui et al. perform a #singlecell #multiomics analysis of human #spermatogenesis and identify a DNA demethylation event upon #meiosis initiation which is associated with #MeioticRecombination. https://www.nature.com/articles/s41556-023-01232-7 https://rdcu.be/dmW9M https://www.nature.com/articles/s41556-023-01232-7 https://rdcu.be/dmW9M"
X Link 2023-09-25T13:11Z 125.5K followers, [----] engagements
"🍹NEW: @yamashitaflylab @zamore_lab & co show that Y-linked Su(Ste) #piRNAs are produced via 5-to-3 phased-biogenesis initiated by maternally deposited 1360/Hoppel-derived piRNAs silencing Ste in male #germline. @IGainetdinov @WhiteheadInst @MITBiology"
X Link 2023-09-26T23:40Z 122.4K followers, [----] engagements
"🍹NEW: Bernab-Rubio et al. report that #dedifferentiation of Gata6+ #EpidermalCells occurs during #woundhealing or mechanical expansion of the #epidermis through a Myc-dependent process that resembles reversal of differentiation. @KCLstemcells https://www.nature.com/articles/s41556-023-01234-5 https://www.nature.com/articles/s41556-023-01234-5"
X Link 2023-09-28T20:47Z 125.6K followers, [----] engagements
"🍹NEW:@ArdehaliHossein & co find a role for the #HistoneDemethylase KDM3B in sensing #ironlevels and regulating #mTORC1 via #transcriptional repression of mTORC1 pathway components. @nu_fcvrri @NUFeinbergMed @NorthwesternMed @NUMSTP https://www.nature.com/articles/s41556-023-01225-6 https://rdcu.be/dnhYk https://www.nature.com/articles/s41556-023-01225-6 https://rdcu.be/dnhYk"
X Link 2023-09-28T21:16Z 125.5K followers, [----] engagements
"🍹NEW: Timms Mena et al. present a multiplex #CRISPR #screeningplatform capable of assigning #E3ligases to their substrates and degrons at scale. #CRISPRscreening"
X Link 2023-09-29T15:29Z 122.4K followers, [----] engagements
"☕NEW: Zhang et al. report curved adhesions which are #integrin-based adhesions formed in response to membrane curvatures that can be imposed by the overlying #extracellularmatrix fibre geometry. @cuilab_chem @StanfordUChem @Stanford_CHEMH @BianxiaoC"
X Link 2023-10-02T21:52Z 121.7K followers, [----] engagements
"☕NEW: Churchman & co share #CRISPRscreen for factors altering the levels of [--] dual-genome-encoded #ComplexIV subunits and identify PREPL and NME6 as genes that connect #MitochondrialMetabolism to #mtDNA expression. @fiddle @GyPrak"
X Link 2023-10-04T12:56Z 121.5K followers, [----] engagements
"🍵Read our new Comment by Small & co on #retromer-dependent #endosomal recycling in #Alzheimersdisease. PDF: https://www.nature.com/articles/s41556-023-01245-2 https://rdcu.be/dn6Le https://www.nature.com/articles/s41556-023-01245-2 https://rdcu.be/dn6Le"
X Link 2023-10-09T12:28Z 125.5K followers, [----] engagements
"☕NEW: Lusk King (@LuskingL @Plusk4u) & co find a grommet-like role for #ESCRTs. The grommet works with #spindle pole body components that establish a #diffusionbarrier to maintain compartmentalization. @NicholasAder @YaleCellBio"
X Link 2023-10-09T12:47Z 122.4K followers, [----] engagements
"☕NEW: @YoshiakiKubota Takubo & co perform #SingleCellRNASequencing and identify a #BoneMarrow #EndothelialCell subtype that contributes to the acquisition of bone strength and offers a distinct #HematopoieticStemCell niche. @Keio_univ_PR"
X Link 2023-10-13T13:09Z 121.8K followers, [----] engagements
"🍵Read our new Comment by @CreweLab @SnigdhaTiash and @BrestoffLab on #MitochondriaTransfer:"
X Link 2023-10-26T12:00Z 121.3K followers, [----] engagements
"☕NEW: Wang Chen & co report that the secretory coat protein complex COPII undergoes liquidliquid #PhaseSeparation that is tuned by #manganese in the cytosol to impact #lipoprotein secretion"
X Link 2023-11-06T13:38Z 121.5K followers, 17.6K engagements
"☕NEW: Hicks (@Mic_Hicks) Pyle (@apyle) & co report in an Open Access study that human regenerating #myofibres expressing #ACTC1 substantially contribute to supporting #PAX7+ #skeletalmuscle progenitor cells. #MuscleRegeneration"
X Link 2023-11-09T13:39Z 121.5K followers, [----] engagements
"☕NEW: Through a #CRISPR-activation screen Ravid Lustig et al. show that #GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate #Xchromosome inactivation in early #MouseEmbryos. @EddaGSchulz @MPI_MolGen"
X Link 2023-11-14T13:23Z 122.4K followers, [----] engagements
"☕NEW: Takakuwa Yamazaki et al. show that the #LongnoncodingRNA #NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish #nuclearspeckles from #paraspeckles to preserve their structural identity. https://www.nature.com/articles/s41556-023-01254-1 https://rdcu.be/dq96p https://www.nature.com/articles/s41556-023-01254-1 https://rdcu.be/dq96p"
X Link 2023-11-15T12:46Z 125K followers, [----] engagements
"🎁Interested in reading more about the study Here is the N&Vs article written by Miroslav Dundr and Jeremy D. Schmit: https://www.nature.com/articles/s41556-023-01265-y https://rdcu.be/dq96V https://www.nature.com/articles/s41556-023-01265-y https://rdcu.be/dq96V"
X Link 2023-11-15T12:46Z 125K followers, [----] engagements
"☕In this issue: Through a #CRISPR-activation screen @EddaGSchulz & co show that #GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate #Xchromosome inactivation in early #MouseEmbryos"
X Link 2023-11-22T20:00Z 121.8K followers, [----] engagements
"💫NEW: Tang & co from @Westlake_Uni describe #mitopherogenesis: the secretion of #mitochondria in mitophers during #SpermDevelopment in C. elegans which controls the #mitochondrial pool and ensure #fertility. #ExtracellularVesicles"
X Link 2023-11-26T22:03Z 121.7K followers, [----] engagements
"💫NEW: @DLawsonlab & co identify and characterize a #tumour-suppressive role for #microglia that mediates a pro-inflammatory response to restrict brain #metastasis in #BreastCancer. #CancerResearch"
X Link 2023-11-28T02:26Z 121.7K followers, 11K engagements
"💫NEW: @SJMorrison_ @Bo_Shen_ & co report that #LeptinReceptor+ #StromalCells sustain #BoneMarrow nerves by producing NGF. Upon myeloablation nerves promote marrow regeneration by increasing the production of growth factors by leptin receptor+ cells"
X Link 2023-12-02T13:15Z 121.7K followers, [----] engagements
"☕🎄In this issue: Munk et al. show that exogenous NAD+ but not its precursors induces metabolic changes in #mitochondria affecting #nucleotide metabolism with impacts on genomic #DNAsynthesis and #GenomeIntegrity. @cancer_dk"
X Link 2023-12-14T13:49Z 121.8K followers, [----] engagements
"💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics"
X Link 2024-01-02T13:41Z 121.7K followers, [----] engagements
"🎂Nature Cell Biology is turning [--] and we are celebrating [--] years of excellence in #cellbiology with a series of commissioned content and a collection of research articles across the journals broad scope. Read the Editorial:"
X Link 2024-01-18T14:06Z 122.4K followers, [----] engagements
"☕In this issue: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics"
X Link 2024-01-27T01:56Z 121.8K followers, [----] engagements
"☕In this issue: Son et al. show that #AMPK- & PP2A-dependent #p300 nucleocytoplasmic shuttling regulates #mTORC1 activity in response to nutrient status. Models of HutchinsonGilford #progeria display increased cytoplasmic p300 and mTORC1 hyperactivation"
X Link 2024-03-04T02:00Z 122.9K followers, 13K engagements
"📢Join us in this Nature conference on September 23-25 in Beijing Register now for the '#Mitochondria and #Immunity' meeting organized by @NatureCellBio @NatMetabolism @NatImmunol and Nankai University. Abstract submission deadline: Aug [--] [----] https://conferences.nature.com/event/Mitochondria/summary https://conferences.nature.com/event/Mitochondria/summary"
X Link 2024-04-04T13:17Z 123.3K followers, [----] engagements
"☕In this issue: New Review article by @OlzmannLab & @alymathiowetz on #LipidDroplet biogenesis mechanisms their role in fatty acid flux in lipotoxicity and #CellDeath and more 👉🏽Read here: https://rdcu.be/dEmCO https://www.nature.com/articles/s41556-024-01364-4 https://rdcu.be/dEmCO https://www.nature.com/articles/s41556-024-01364-4"
X Link 2024-04-11T00:15Z 123.3K followers, 15.2K engagements
"A study by @Marteijnlab @oncodeinstitute @MolecularGenet3 & co: https://www.nature.com/articles/s41556-024-01394-y https://www.nature.com/articles/s41556-024-01394-y"
X Link 2024-04-30T12:25Z 123.5K followers, [----] engagements
"☕In this issue: A Comment on #VolumeElectronMicroscopy standards in sample preparation and image acquisition for enhanced reproducibility and data reuse. https://www.nature.com/articles/s41556-024-01381-3 https://rdcu.be/dGMhZ https://www.nature.com/articles/s41556-024-01381-3 https://rdcu.be/dGMhZ"
X Link 2024-05-05T00:55Z 123.6K followers, [----] engagements
"💫NEW by Palmulli Couty et al: CD63 promotes #cholesterol accumulation in intraluminal vesicles (ILVs) at the expense of retrieval from #endosomes; cholesterol stored in ILVs and exosomes is recovered in an NPC1-dependent manner. https://www.nature.com/articles/s41556-024-01432-9 https://rdcu.be/dNCzQ https://www.nature.com/articles/s41556-024-01432-9 https://rdcu.be/dNCzQ"
X Link 2024-07-12T21:05Z 124.4K followers, [----] engagements
"💫2 new studies by Agarwal et al. and Wang et al. show that vesicle-associated membrane protein [--] (VAMP2) interacts with and regulates #AlphaSynuclein #BiomolecularCondensation affecting -synuclein function which may prevent pathological amyloid aggregation. 👇🏾see below:"
X Link 2024-07-22T17:12Z 124.4K followers, [----] engagements
"💫NEW: Sun Tao Han et al. identify the Rabs involved in unconventional protein secretion mediated by TMED10 and in ERGolgi intermediate compartment organization. https://www.nature.com/articles/s41556-024-01445-4 https://rdcu.be/dOAv5 https://www.nature.com/articles/s41556-024-01445-4 https://rdcu.be/dOAv5"
X Link 2024-07-22T22:00Z 124.5K followers, [----] engagements
"💫NEW: Wu & co report that upon ultraviolet-C radiation full-length #GSDME can induce #pyroptosis without cleavage. https://www.nature.com/articles/s41556-024-01463-2 https://rdcu.be/dQQA5 https://www.nature.com/articles/s41556-024-01463-2 https://rdcu.be/dQQA5"
X Link 2024-08-13T18:28Z 124.2K followers, [----] engagements
"💫NEW: Schwab Rao et al. report that Zeb1 mediates enhanced #ferroptosis sensitivity in #cancer cells after #EMT activation associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio. https://www.nature.com/articles/s41556-024-01464-1 https://www.nature.com/articles/s41556-024-01464-1"
X Link 2024-08-15T08:53Z 125.6K followers, [----] engagements
"💫NEW: @JuliaMMagdalena @amitmechaging @KrizhanovskyLab & co show that #p16-expressing #senescent cells enhance PD-L1 stability by downregulating its proteasome-mediated degradation leading to their accumulation in aging and chronic inflammation. https://www.nature.com/articles/s41556-024-01465-0 https://www.nature.com/articles/s41556-024-01465-0"
X Link 2024-09-02T16:39Z 125.6K followers, [----] engagements
"💫NEW: Guo Hong et al. report that #TET2 condensation maintains proper #DNAdemethylation at specific genomic loci which can be targeted to alter gene expression and impair #leukemia growth. @Yun_Nancy_Huang @ZhouLaboratory https://www.nature.com/articles/s41556-024-01496-7 https://rdcu.be/dUBQM https://www.nature.com/articles/s41556-024-01496-7 https://rdcu.be/dUBQM"
X Link 2024-09-21T12:21Z 125.6K followers, 12.2K engagements
"💫NEW: Yang et al show that #PlasmaMembrane curvature promotes the site-specific formation of contacts with the #EndoplasmicReticulum through junctophilin-2 tethers in #cardiomyocytes. @cuilab_chem @StanfordUChem @Stanford_CHEMH @BianxiaoC @YangYang0511 https://www.nature.com/articles/s41556-024-01511-x https://www.nature.com/articles/s41556-024-01511-x"
X Link 2024-09-27T12:29Z 125.6K followers, [----] engagements
"💫NEW: Yuzhalin et al. show that #astrocyte-mediated Cdk5 upregulation in metastatic #BreastCancer inhibits MHC-I cell surface expression thus enabling escape from killing by #CD8T cells and facilitating #BrainMetastasis. https://www.nature.com/articles/s41556-024-01509-5 https://rdcu.be/dVNgf https://www.nature.com/articles/s41556-024-01509-5 https://rdcu.be/dVNgf"
X Link 2024-10-02T15:59Z 125.6K followers, [----] engagements
"💫NEW: Bose (@MainakB78580463) Rankovic et al. show that a specific RNARNA kissing-loop interaction plays a crucial role in driving #BiomolecularCondensation of #ribonucleoprotein granules in the Drosophila #germline. @embl https://www.nature.com/articles/s41556-024-01519-3 https://www.nature.com/articles/s41556-024-01519-3"
X Link 2024-10-03T09:13Z 124.3K followers, [----] engagements
"💫NEW by @toettch @h4rrymcnamara & co: synthetic signal-recording gene circuits on mouse #gastruloids show that cell sorting rearranges patchy domains of Wnt activity into a single pole that defines the anteriorposterior axis. https://www.nature.com/articles/s41556-024-01521-9 https://rdcu.be/dVTQc https://www.nature.com/articles/s41556-024-01521-9 https://rdcu.be/dVTQc"
X Link 2024-10-03T12:31Z 125.6K followers, [----] engagements
"💫NEW: @fran_bottanelli @A_STEDhammer @petiaadarska & co describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-#Golgi sorting. @fubcp @FU_Berlin https://www.nature.com/articles/s41556-024-01518-4 https://www.nature.com/articles/s41556-024-01518-4"
X Link 2024-10-11T12:45Z 125.6K followers, [----] engagements
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