#  @NatMetabolism Nature Metabolism Nature Metabolism posts on X about weight loss, health, vivo, in the the most. They currently have [------] followers and [---] posts still getting attention that total [------] engagements in the last [--] hours. ### Engagements: [------] [#](/creator/twitter::937615164320440320/interactions)  - [--] Week [-----] -8.20% - [--] Month [-------] -41% - [--] Months [---------] +3,061% - [--] Year [---------] +407% ### Mentions: [--] [#](/creator/twitter::937615164320440320/posts_active)  - [--] Month [--] +18% - [--] Months [---] +355% - [--] Year [---] +144% ### Followers: [------] [#](/creator/twitter::937615164320440320/followers)  - [--] Week [------] +0.17% - [--] Month [------] +0.75% - [--] Months [------] +5.40% - [--] Year [------] +13% ### CreatorRank: undefined [#](/creator/twitter::937615164320440320/influencer_rank)  ### Social Influence **Social category influence** [currencies](/list/currencies) [travel destinations](/list/travel-destinations) [technology brands](/list/technology-brands) [countries](/list/countries) [finance](/list/finance) [stocks](/list/stocks) [formula 1](/list/formula-1) [luxury brands](/list/luxury-brands) [automotive brands](/list/automotive-brands) [ncaa football](/list/ncaa-football) **Social topic influence** [weight loss](/topic/weight-loss), [health](/topic/health), [vivo](/topic/vivo), [in the](/topic/in-the), [accumulation](/topic/accumulation), [$6963t](/topic/$6963t), [human](/topic/human), [enzyme](/topic/enzyme), [ros](/topic/ros), [study](/topic/study) **Top accounts mentioned or mentioned by** [@cambridgeuni](/creator/undefined) [@clemmensenc](/creator/undefined) [@cellmetabolism](/creator/undefined) [@harvardmed](/creator/undefined) [@pku1898](/creator/undefined) [@amgen](/creator/undefined) [@unibonn](/creator/undefined) [@weillcornell](/creator/undefined) [@pennmedicine](/creator/undefined) [@nusingapore](/creator/undefined) [@karolinskainst](/creator/undefined) [@danafarber](/creator/undefined) [@ucla](/creator/undefined) [@longlabstanford](/creator/undefined) [@stanfordpath](/creator/undefined) [@johannesmeiser](/creator/undefined) [@lihluxembourg](/creator/undefined) [@cecad](/creator/undefined) [@nature](/creator/undefined) [@naturemedicine](/creator/undefined) **Top assets mentioned** [Enzyme (MLN)](/topic/enzyme) [GLP1 (GLP1)](/topic/glp1) [Flux (FLUX)](/topic/flux) [XIAO (XIAO)](/topic/xiao) [Novartis AG (NVS)](/topic/novartis) ### Top Social Posts Top posts by engagements in the last [--] hours "Bile acid binds heart failure and inflammation - Nature Metabolism Mao et al. discover that heart failure-associated metabolic derangement results in cardiomyocyte cholesterol overload and accumulation of bile acid intermediates which in turn trigger mitochondrial damage and inflammatory activation and thus promote heart failure" [X Link](https://www.nature.com/articles/s42255-023-00836-5) 2023-07-13T00:00Z 70.9K followers, [---] engagements "The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation - Nature Metabolism Nature Metabolism - The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation" [X Link](https://www.nature.com/articles/s42255-024-01076-x) 2024-06-25T00:00Z 72.4K followers, 19.7K engagements "Time of sample collection is critical for the replicability of microbiome analyses Nature Metabolism Allaband et al. analyse how timing of sample collection affects the conclusions that can be drawn from microbiome studies which has implications for study design" [X Link](https://www.nature.com/articles/s42255-024-01064-1) 2025-04-03T05:09Z 228.6M followers, [--] engagements "Gut microbiome pattern reflects healthy ageing and predicts survival in humans - Nature Metabolism Increasing compositional uniqueness of the gut microbiome and corresponding changes in microbial metabolites in the blood are identified as a signature of healthy ageing in humans" [X Link](https://www.nature.com/articles/s42255-021-00348-0) 2021-02-18T00:00Z 228.6M followers, 748K engagements "Slc12a8 is a nicotinamide mononucleotide transporter Nature Metabolism Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter encoded by the Slc12a8 gene which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo" [X Link](https://www.nature.com/articles/s42255-018-0009-4) 2021-04-21T14:57Z 2.1M followers, 513.6K engagements "PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels - Nature Metabolism PAQR4 regulates cellular ceramide synthesis and accumulation to mediate adipose tissue function glucose homoeostasis and thus systemic metabolic health" [X Link](https://www.nature.com/articles/s42255-024-01078-9) 2024-07-03T00:00Z 68.7K followers, [----] engagements "Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection - Nature Metabolism Fiorina and colleagues document alterations in glucose metabolism in patients with COVID-19 and use continuous glucose monitoring to show that glycaemic abnormalities could still be detected [--] months after disease onset in patients who had recovered" [X Link](https://www.nature.com/articles/s42255-021-00407-6) 2021-05-25T00:00Z 208.1M followers, [---] engagements "High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy Nature Metabolism Zhang et al. show that high-protein diets increase atherosclerosis risk through macrophage mTORC1 activation associated with suppressed clearance of damaged mitochondria and increased apoptosis" [X Link](https://www.nature.com/articles/s42255-019-0162-4) 2025-09-11T13:24Z 208.1M followers, [--] engagements "Metabolic links among milk genes and gut Nature Metabolism Genotype at the LCT locus determines lactase expression and very notably varies across populations. Milk intake variably influences the aetiology of the risk of type [--] diabetes depending on ancestry. In this issue of Nature Metabolism Luo et al. describe how increased milk intake modifies both gut bacterial abundances and circulating metabolites in favour of decreasing the risk of type [--] diabetes in individuals who are lactase-deficient" [X Link](https://www.nature.com/articles/s42255-023-00958-w) 2024-01-23T00:25Z 208.1M followers, 16.7K engagements "A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals Nature Metabolism The glucagon-like peptide [--] receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta) three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs" [X Link](https://www.nature.com/articles/s42255-025-01383-x) 2025-09-25T10:21Z 208.1M followers, [----] engagements "Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study Nature Metabolism The SWEET project is a multicenter randomized controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity" [X Link](https://www.nature.com/articles/s42255-025-01381-z) 2025-10-07T10:16Z 2.1M followers, 179.9K engagements "Towards nutrition with precision: unlocking biomarkers as dietary assessment tools - Nature Metabolism The authors provide an update on the most useful biomarkers in urine and blood for assessing food intake and delineate strategies that may accelerate the application of biomarkers of food intake for improving human nutritional research" [X Link](https://www.nature.com/articles/s42255-024-01067-y) 2024-07-02T00:00Z 70.9K followers, [----] engagements "Short-term effects of high-protein lower-carbohydrate ultra-processed foods on human energy balance Nature Metabolism This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning" [X Link](https://www.nature.com/articles/s42255-025-01247-4) 2025-03-22T04:38Z 2.1M followers, 306.9K engagements "The cyclic metabolic switching theory of intermittent fasting Nature Metabolism In this Perspective Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets" [X Link](https://www.nature.com/articles/s42255-025-01254-5) 2025-03-14T13:31Z 208.1M followers, [----] engagements "Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution Nature Metabolism In this Review the authors present a roadmap towards achieving consensus on development analysis and interpretation of single-cell transcriptomics data in adipose tissue including discussion of roadblocks best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans" [X Link](https://www.nature.com/articles/s42255-025-01296-9) 2025-09-04T18:00Z 2.1M followers, [----] engagements "ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response - Nature Metabolism Lim Adler et al. show that the urea cycle enzyme ASS1 can function in the nucleus to supply fumarate necessary to drive DNA damage responses" [X Link](https://www.nature.com/articles/s42255-024-01060-5) 2024-06-10T00:00Z 70.9K followers, [----] engagements "A high-protein diet prevents weight regain Nature Metabolism Sustained weight loss and weight maintenance are key challenges for the treatment of obesity. Here the authors show that a high-protein diet following weight loss can protect against weight regain through a process dependent on the gut microbiome" [X Link](https://www.nature.com/articles/s42255-022-00699-2.pdf) 2024-09-03T17:10Z 208.1M followers, 11.7K engagements "Natural killer loops: pyruvate in lactate out - Nature Metabolism Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate which regenerates cytosolic NAD+ via metabolism to lactate to support glycolysis and fuels oxidative phosphorylation via the mitochondrial citratemalate shuttle" [X Link](https://www.nature.com/articles/s42255-024-01195-5) 2025-01-03T00:00Z 72.7K followers, [---] engagements "GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management - Nature Metabolism Holst reflects on the development of GLP-1-based drugs for the therapy of obesity from early observations to remarkable results in more recent clinical trials discussing physiological pharmacological and clinical considerations related to their use" [X Link](https://www.nature.com/articles/s42255-024-01113-9) 2024-08-19T00:00Z 228.6M followers, 13.4K engagements "The metabolic and functional roles of sensory nerves in adipose tissues Nature Metabolism Mishra and Townsend present an overview of the regulation function and plasticity of adipose tissue sensory nerves that are relevant for metabolic processes in health and disease" [X Link](https://www.nature.com/articles/s42255-023-00868-x) 2025-09-09T15:06Z 208.1M followers, [----] engagements "Cardiac glycosides are broad-spectrum senolytics - Nature Metabolism In addition to having direct anti-cancer effects the cardiac glycoside ouabain is shown to kill a broad range of senescent cells thus suggesting that cardiac glycosides represent a novel class of senolytics" [X Link](https://www.nature.com/articles/s42255-019-0122-z) 2019-10-21T00:00Z 72.5K followers, [---] engagements "Itaconate modulates mitochondria for antiviral IFN- - Nature Metabolism Itaconate is an immunomodulatory metabolite that influences the outcome of infections and inflammatory diseases. New evidence indicates that itaconate-induced inhibition of succinate dehydrogenase regulates type [--] interferon production via the release of mitochondrial RNA linking TCA cycle modulation to antiviral interferon responses" [X Link](https://www.nature.com/articles/s42255-024-01146-0) 2024-10-15T00:00Z 71.8K followers, [----] engagements "Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo - Nature Metabolism Grankvist et al. combine global isotopic tracing and metabolic flux modelling to characterize metabolic networks in human intact liver tissue" [X Link](https://www.nature.com/articles/s42255-024-01119-3) 2024-08-29T00:00Z 71.4K followers, [----] engagements "Role and therapeutic potential of dietary ketone bodies in lymph vessel growth - Nature Metabolism Caused by a compromised lymphatic system lymphoedema leads to fluid retention and tissue swelling and is treated primarily with physical therapy. Here the authors present a metabolic approach to reduce lymphoedema by providing the ketone body -hydroxybutyrate or by feeding ketogenic diet which increases lymphangiogenesis and reduces fluid retention in mice" [X Link](https://www.nature.com/articles/s42255-019-0087-y) 2019-07-12T00:00Z 72.4K followers, [--] engagements "Shooting for the stars: caspase-8meteorin in MASH and fibrosis Nature Metabolism In this issue of Nature Metabolism Wang et al. identified a non-apoptotic caspase-8 function in metabolic dysfunction-associated steatohepatitis (MASH) in which hepatocyte-derived caspase-8 induces meteorin which in turn activates hepatic stellate cells (HSCs) to drive fibrosis. This function reveals a potential therapeutic target to directly address fibrosis and reduce the progression of metabolic dysfunction-associated steatotic liver disease (MASLD)" [X Link](https://www.nature.com/articles/s42255-025-01361-3) 2025-09-27T08:04Z 208.1M followers, [---] engagements "A safety guide for transgenic Cre drivers in metabolism - Nature Metabolism Despite the high utility and widespread use of Cre driver lines lack of Cre specificity Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research" [X Link](https://www.nature.com/articles/s42255-024-01087-8) 2024-08-19T00:00Z 208.1M followers, [----] engagements "The metabolic roots of senescence: mechanisms and opportunities for intervention Nature Metabolism Wiley and Campisi discuss metabolic inducers of senescence and alterations in cellular metabolism associated with senescence while pointing out interventions that target metabolic processes to mitigate senescence" [X Link](https://www.nature.com/articles/s42255-021-00483-8) 2025-09-19T01:58Z 228.6M followers, [--] engagements "Metabolic Messengers: small extracellular vesicles Nature Metabolism Olefsky Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history role as biomarkers mechanisms of action and therapeutic potential" [X Link](https://www.nature.com/articles/s42255-024-01214-5) 2025-02-08T13:15Z 2.1M followers, [----] engagements "Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota Nature Metabolism Dietary methionine restriction has been reported to protect from cancer. Ji et al. describe a cancer-promoting effect of methionine restriction mediated by gut microbiota-induced sulfur deficiency and suppression of antitumour immunity" [X Link](https://www.nature.com/articles/s42255-023-00854-3) 2025-09-08T02:28Z 208.1M followers, [--] engagements "Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging but was originally thought to be unattainable. However recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality thanks to the development of nano secondary ion mass spectrometry" [X Link](https://www.nature.com/articles/s42255-023-00882-z) 2023-09-07T00:00Z 70.9K followers, [----] engagements "Impaired striatal glutathioneascorbate metabolism induces transient dopamine increase and motor dysfunction - Nature Metabolism Malik Guo et al. show that Ntrk2/Trkb-mediated neurotrophic signalling regulates dopamine levels by controlling glutathioneascorbate metabolism thus impacting striatal dopaminergic circuits and motor function" [X Link](https://www.nature.com/articles/s42255-024-01155-z) 2024-10-28T00:00Z 208.1M followers, [----] engagements "Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation Nature Metabolism Xia et al. show that the activity of the small GTPase RalA is increased in white adipocytes in diet-induced obese mice. RalA enhances mitochondrial fission and therefore reduces energy expenditure which contributes to weight gain" [X Link](https://www.nature.com/articles/s42255-024-00978-0) 2024-03-31T13:04Z 2.1M followers, 36.2K engagements "Why a good lab website matters - Nature Metabolism Lab websites are an important resource for making yourself known to the research community. Here we explain why having an informative up-to-date website can be a great tool for keeping the research community informed about your current projects" [X Link](https://www.nature.com/articles/s42255-023-00797-9) 2023-04-26T00:00Z 71.1K followers, 206.2K engagements "Artificial intelligence in metabolic research Nature Metabolism The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint we asked [--] experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research" [X Link](https://www.nature.com/articles/s42255-025-01395-7) 2025-10-02T10:42Z 228.6M followers, 20.3K engagements "Molecular control of endurance training adaptation in male mouse skeletal muscle - Nature Metabolism The authors explore the molecular signature of skeletal muscle adaptations to an acute bout of exercise in mice providing a valuable resource that includes transcriptomic epigenetic proteomic and phosphoproteomic changes in muscle plasticity" [X Link](https://www.nature.com/articles/s42255-023-00891-y) 2023-09-11T00:00Z 70.9K followers, 18.6K engagements "NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD - Nature Metabolism Chronic obstructive pulmonary disease is a severe inflammatory lung disease characterized by obstructed airflow from the lungs. Here Seimetz et al. show that NADPH oxidase subunit [--] (NOXO1) is responsible for peroxynitrite formation from nitric oxide and superoxide and drives the development of smoke-induced emphysema and pulmonary hypertension" [X Link](https://www.nature.com/articles/s42255-020-0215-8) 2020-06-08T00:00Z 70.9K followers, [--] engagements "Big data and personalized nutrition: the key evidence gaps Nature Metabolism The field of personalized nutrition hypothesizes that ‘big data’ — biological behavioural social and environmental — can be leveraged to make more precise and effective dietary recommendations to individuals for improving health outcomes compared to generic dietary advice. This article describes the research questions that need to be answered to understand whether personalized nutrition brings additional clinical utility" [X Link](https://www.nature.com/articles/s42255-023-00960-2) 2025-08-14T16:27Z 228.6M followers, [----] engagements "Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights Nature Metabolism In a randomized crossover clinical trial in healthy young adults with varying weights sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motivation and somatosensory processing" [X Link](https://www.nature.com/articles/s42255-025-01227-8) 2025-03-26T19:05Z 2.1M followers, 253.3K engagements "A short-term high-caloric diet has prolonged effects on brain insulin action in men Nature Metabolism Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men which outlasted the time-frame of overeating" [X Link](https://www.nature.com/articles/s42255-025-01226-9) 2025-02-28T22:06Z 228.6M followers, [----] engagements "The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade - Nature Metabolism Qiu et al. provide insight into the metabolic adaptations that enable breast cancer cells to proliferate in the face of glutaminolysis blockade" [X Link](https://www.nature.com/articles/s42255-024-01104-w) 2024-08-27T00:00Z 70.9K followers, [--] engagements "TrkB signalling regulates dopamine circuits and motor function through metabolic pathways - Nature Metabolism A common feature of neurodegenerative diseases is that select neuronal types are particularly sensitive to disease pathology at early stages. Altered TrkB signalling in the neuronal type most affected by Huntingtons disease increased expression of the enzyme GSTO2 leading to dopaminergic dysfunction impaired energy metabolism progressive degeneration and hyperkinetic symptoms" [X Link](https://www.nature.com/articles/s42255-024-01154-0) 2024-10-28T00:00Z 72.4K followers, [--] engagements "Feeding gut microbes to nourish the brain: unravelling the dietmicrobiotagutbrain axis - Nature Metabolism This Review provides an overview of the interplay between host diet and the gut microbiota and how this affects brain function" [X Link](https://www.nature.com/articles/s42255-024-01108-6) 2024-08-22T00:00Z 208.1M followers, 44K engagements "Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain Nature Metabolism A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors and are used to image receptor binding activities in tissues and animals" [X Link](https://www.nature.com/articles/s42255-025-01342-6) 2025-08-19T13:51Z 208.1M followers, [----] engagements "Mapping biological influences on the human plasma proteome beyond the genome - Nature Metabolism The authors systematically study biological influences on the human plasma proteome in a large cohort thereby revealing causal associations between plasma proteins and modifiable risk factors for proteindisease associations" [X Link](https://www.nature.com/articles/s42255-024-01133-5) 2024-09-26T00:00Z 70.9K followers, [---] engagements "Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice Nature Metabolism The intestinal symbiont Desulfovibrio which is enriched in individuals with metabolic syndrome is found to suppress the production of GLP-1 in male mice. The over-the-counter drug bismuth subsalicylate inhibits the effect of Desulfovibrio and restores GLP-1 levels" [X Link](https://www.nature.com/articles/s42255-024-01068-x) 2024-08-09T12:14Z 2.1M followers, 193.8K engagements "Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21 Nature Metabolism Extended exposure to breastfeeding in rodent pups protects them from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This is mediated by liver-derived FGF21 signalling to the lateral hypothalamic area" [X Link](https://www.nature.com/articles/s42255-022-00602-z) 2022-08-16T15:54Z 208.1M followers, [--] engagements "Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk - Nature Metabolism Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease" [X Link](https://www.nature.com/articles/s42255-024-00984-2) 2024-02-19T00:00Z 228.6M followers, 283.2K engagements "Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type [--] diabetes risk - Nature Metabolism Dietary haem iron intake is linked with a higher type [--] diabetes risk. This dietary association is further supported by circulating metabolic and metabolomic biomarker data" [X Link](https://www.nature.com/articles/s42255-024-01109-5) 2024-08-13T00:00Z 208.1M followers, [--] engagements "Mitochondrial transplants to treat mitochondrial dysfunction Nature Metabolism A new approach to treating mitochondrial disorders is based on the transplantation of healthy mitochondria and improves symptoms and survival in a mouse model of Leigh syndrome — a paediatric mitochondrial disease that is characterized by failure to thrive lactic acidosis and progressive degeneration" [X Link](https://www.nature.com/articles/s42255-024-01124-6) 2025-09-11T17:33Z 208.1M followers, [----] engagements "Metagenomic estimation of dietary intake from human stool Nature Metabolism Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes" [X Link](https://www.nature.com/articles/s42255-025-01220-1) 2025-02-18T20:22Z 228.6M followers, [----] engagements "Iron accumulation drives fibrosis senescence and the senescence-associated secretory phenotype - Nature Metabolism Iron is shown to have a central role in senescence both by triggering senescence and through its accumulation in senescent cells which is driving the senescence-associated secretory phenotype and in turn promotes fibrogenesis" [X Link](https://www.nature.com/articles/s42255-023-00928-2) 2023-12-14T00:00Z 70.9K followers, [---] engagements "Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism Kovatcheva et al. show that vitamin B12 improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation" [X Link](https://www.nature.com/articles/s42255-023-00916-6) 2023-11-16T00:00Z 71.1K followers, [----] engagements "Hindbrain circuits in the control of eating behaviour and energy balance - Nature Metabolism The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding as well as for the long-term control of body weight" [X Link](https://www.nature.com/articles/s42255-022-00606-9) 2022-07-25T00:00Z 70.9K followers, [--] engagements "Molecular consequences of SARS-CoV-2 liver tropism Nature Metabolism Wanner et al. demonstrate SARS-CoV-2 liver tropism and identify transcriptional and proteomic profiles of SARS-CoV-2 liver samples that show similarities to previously characterized hepatotropic viruses" [X Link](https://www.nature.com/articles/s42255-022-00552-6) 2022-05-07T22:10Z 2.1M followers, [---] engagements "Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages Nature Metabolism Senescent cells in fat and liver are shown to attract M1-like macrophages with increased expression of the NAD-consuming enzyme CD38 leading to their local accumulation and providing a mechanism for the age-associated decline in tissue NAD+ levels" [X Link](https://www.nature.com/articles/s42255-020-00305-3) 2021-03-07T15:13Z 2.1M followers, 46.1K engagements "Dynamic lipidome alterations associated with human health disease and ageing - Nature Metabolism Longitudinal deep lipidome profiling reveals [---] lipid species many of which are associated with health-to-disease transitions in diabetes ageing and inflammation" [X Link](https://www.nature.com/articles/s42255-023-00880-1) 2023-09-11T00:00Z 70.9K followers, 44.6K engagements "Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake Nature Metabolism Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription thereby coupling glucose uptake to organismal energy expenditure" [X Link](https://www.nature.com/articles/s42255-021-00359-x) 2025-09-14T18:45Z 208.1M followers, 22.4K engagements "Metabolic heterogeneity in cancer - Nature Metabolism Demicco Liu et al. discuss how metabolic adaptations in cancer contribute to tumour progression. These adaptations entail high spatial and temporal metabolic heterogeneity based on local adaptations in different regions of the tumour microenvironment as well as metabolic evolution over time as the tumour progresses and metastasizes" [X Link](https://www.nature.com/articles/s42255-023-00963-z) 2024-01-24T00:00Z 72.7K followers, 12K engagements "Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins - Nature Metabolism The NAD+ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase which restricts the virion incorporation of viral proteins and underpins its antiviral effect" [X Link](https://www.nature.com/articles/s42255-024-01162-0) 2024-11-21T00:00Z 72.7K followers, [----] engagements "Activation of GPR81 by lactate drives tumour-induced cachexia - Nature Metabolism Tumour-derived lactate activates adipose GPR81 which in turn leads to cachexia. Targeting GPR81 and its downstream signalling pathway holds therapeutic potential for treating cancer cachexia" [X Link](https://www.nature.com/articles/s42255-024-01011-0) 2024-03-18T00:00Z 72.5K followers, [----] engagements "Lac-Phe mediates the effects of metformin on food intake and body weight - Nature Metabolism Metformin is shown to trigger production and release of Lac-Phe from gut epithelial cells which is required for its effects on food intake and loss of body weight" [X Link](https://www.nature.com/articles/s42255-024-00999-9) 2024-03-18T00:00Z 72.3K followers, [----] engagements "The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents" [X Link](https://www.nature.com/articles/s42255-025-01237-6) 2025-03-24T10:41Z 228.6M followers, [----] engagements "Systemic proteome adaptions to 7-day complete caloric restriction in humans - Nature Metabolism The authors describe distinct phases of adaptions in the human plasma proteome to [--] days without food with profound changes occurring only after [--] days" [X Link](https://www.nature.com/articles/s42255-024-01008-9) 2024-03-01T00:00Z 2.1M followers, [----] engagements "Metabolic Messengers: oestradiol Nature Metabolism Hevener and Correa provide a comprehensive overview of the preclinical and clinical evidence showing the metabolic role of oestradiol and its receptors in both women and men" [X Link](https://www.nature.com/articles/s42255-025-01317-7) 2025-07-27T00:28Z 208.1M followers, [----] engagements "NAD+ precursor supplementation in human ageing: clinical evidence and challenges Nature Metabolism This Review summarizes existing data as well as crucial knowledge gaps emerging from clinical trials involving NAD+ precursor supplementation in humans" [X Link](https://www.nature.com/articles/s42255-025-01387-7) 2025-10-13T16:51Z 2.1M followers, 15K engagements "Characterization of genetic variants of GIPR reveals a contribution of -arrestin to metabolic phenotypes - Nature Metabolism Molecular pharmacological characterization and association testing of human GIPR genetic variants with follow-up analysis in mice shows that -arrestins regulate GIPR signalling and thereby strongly contribute to metabolic outcomes" [X Link](https://www.nature.com/articles/s42255-024-01061-4) 2024-06-13T00:00Z 72.3K followers, [----] engagements "Fructose stimulated de novo lipogenesis is promoted by inflammation - Nature Metabolism Fructose consumption has greatly increased in recent years and has been linked to the development of hepatic steatosis. Here the authors show that fructose promotes gut-barrier deterioration and subsequent endotoxaemia that in turn induces hepatic lipogenesis by activation TLR signalling in liver macrophages" [X Link](https://www.nature.com/articles/s42255-020-0261-2) 2020-08-24T00:00Z 72.3K followers, 73.3K engagements "Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke Nature Metabolism Wang et al. report a workflow to perform quantitative mass spectrometry imaging and provide insight into spatial metabolic remodelling undergone in the mouse brain upon ischaemia" [X Link](https://www.nature.com/articles/s42255-025-01340-8) 2025-10-11T15:57Z 208.1M followers, [----] engagements "Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals Nature Metabolism A new methodology uses intravital time-gated mid-infrared optoacoustic signals for accurate non-invasive measurements of glucose concentrations in blood-rich volumes of the skin" [X Link](https://www.nature.com/articles/s42255-024-01016-9) 2024-04-19T15:54Z 2.1M followers, [---] engagements "GIPR-Ab/GLP-1 peptideantibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice Nature Metabolism This study together with a companion manuscript shows that in mice weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms" [X Link](https://www.nature.com/articles/s42255-025-01295-w) 2025-05-04T08:25Z 208.1M followers, [----] engagements "Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota - Nature Metabolism In a randomized placebo-controlled trial in [--] individuals with excess body weight dietary supplementation with resistant starch lowers body weight and induces changes in gut microbiota composition. Mechanistic analysis in male mice shows that resistant starch at least partially facilitates weight loss through the action of Bifidobacterium adolescentis" [X Link](https://www.nature.com/articles/s42255-024-00988-y) 2024-02-26T00:00Z 208.1M followers, [--] engagements "Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study - Nature Metabolism Modest weight gain leads to greater adverse metabolic consequences in South Asian compared to European men in part driven by differences in adipocyte morphology" [X Link](https://www.nature.com/articles/s42255-024-01101-z) 2024-08-16T00:00Z 70.9K followers, [----] engagements "Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice Nature Metabolism This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake" [X Link](https://www.nature.com/articles/s42255-025-01377-9) 2025-10-11T09:00Z 62.3K followers, [--] engagements "Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type [--] diabetes aetiology - Nature Metabolism In a genome-wide association study for traits related to pancreatic beta-cell function in [-----] individuals [--] independent associations mapping to [--] genetic loci are identified" [X Link](https://www.nature.com/articles/s42255-024-01140-6) 2024-10-17T00:00Z 208.1M followers, [----] engagements "Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts which identify conserved as well as divergent metabolic patterns" [X Link](https://www.nature.com/articles/s42255-025-01338-2) 2025-08-03T17:31Z 208.1M followers, [----] engagements "CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure Nature Metabolism This carefully designed study demonstrates that CagriSema overcomes metabolic adaptation in response to weight loss in rats" [X Link](https://www.nature.com/articles/s42255-025-01324-8) 2025-07-08T12:24Z 208.1M followers, [----] engagements "A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type [--] diabetes - Nature Metabolism Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type [--] diabetes" [X Link](https://www.nature.com/articles/s42255-024-01159-9) 2024-11-04T00:00Z 71.1K followers, 41.3K engagements "Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis - Nature Metabolism The authors uncover the role of cellular Feimin in regulating exercise performance by modulating SLN-mediated muscle thermogenesis" [X Link](https://www.nature.com/articles/s42255-024-01176-8) 2025-01-02T00:00Z 72.7K followers, [--] engagements "Enzyme engineering to fight mitochondrial diseases - Nature Metabolism Inherited deficiencies in oxidative phosphorylation cause severe mitochondrial disease. A recent study in Nature Biotechnology demonstrates that an engineered bifunctional enzyme can rescue the biochemical consequences of mitochondrial dysfunction" [X Link](https://www.nature.com/articles/s42255-020-0177-x) 2020-02-17T00:00Z 70.9K followers, [--] engagements "Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction - Nature Metabolism The authors of this Perspective argue that the commonly used terms mitochondrial function and mitochondrial dysfunction do not do justice to the diverse mitochondrial features activities functions and behaviours within cells and thus call for the field to adopt more specific terminology in th" [X Link](https://www.nature.com/articles/s42255-023-00783-1) 2023-04-26T00:00Z 208.1M followers, 44.8K engagements "Metabolic Messenger: growth differentiation factor [--] Nature Metabolism Breit and Tsai provide a concise overview of the role of GDF15 as a signalling molecule in the context of metabolic health and disease" [X Link](https://www.nature.com/articles/s42255-025-01353-3) 2025-10-07T16:00Z 2.1M followers, [----] engagements "GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9 - Nature Metabolism Glucose-dependent insulinotropic polypeptide (GIP) is a gut incretin hormone released in response to nutrients. Here the authors report an anti-inflammatory and antiobesogenic mechanism of GIP by showing that loss of GIP receptor signalling in myeloid cells promotes pro-inflammatory S100A8/A9 release in adipose tissue" [X Link](https://www.nature.com/articles/s42255-018-0001-z) 2018-11-19T00:00Z 72.7K followers, [----] engagements "Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA - Nature Metabolism The authors identify a role for GABRA5 neurons in the lateral hypothalamus for energy balance regulation. Inhibiting these neurons increases weight gain and lipid accumulation through a process dependent on astrocytic GABA release" [X Link](https://www.nature.com/articles/s42255-023-00877-w) 2023-08-31T00:00Z 70.9K followers, [----] engagements "Ketogenesis activates metabolically protective T cells in visceral adipose tissue Nature Metabolism The ketogenic diet is a low-carbohydrate high-fat diet that forces a metabolic switch towards fatty acid oxidation. Here Goldberg et al. show that a ketogenic diet initially improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemic control during obesity" [X Link](https://www.nature.com/articles/s42255-019-0160-6) 2020-10-16T20:02Z 208.1M followers, 30.5K engagements "Metabolic Messengers: bile acids - Nature Metabolism Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis" [X Link](https://www.nature.com/articles/s42255-022-00559-z) 2022-03-25T00:00Z 70.9K followers, [----] engagements "Diabetes IL-10 and the brains microvascular crisis - Nature Metabolism A new study finds that capillary vessels become obstructed in diabetes and that their dysfunction may cause microvascular damage and lead to cognitive deficits. Such obstruction is independent of the elevated blood sugar found in diabetes and is triggered by elevated interleukin-10 cytokine signalling in cerebral blood vessel endothelial cells" [X Link](https://www.nature.com/articles/s42255-024-01161-1) 2024-11-04T00:00Z 71.9K followers, 46.5K engagements "Central and peripheral GLP-1 systems independently suppress eating - Nature Metabolism GLP-1 is an incretin hormone and neuromodulator produced by gut enterocytes and CNS neurons. Brierley et al. find that GLP-1 from peripheral and central sources acts independently through distinct gutbrain circuits to suppress eating" [X Link](https://www.nature.com/articles/s42255-021-00344-4) 2021-02-15T00:00Z 68.7K followers, [---] engagements "Total daily energy expenditure has declined over the past three decades due to declining basal expenditure not reduced activity expenditure - Nature Metabolism Using a database of doubly labelled water energy expenditure measurements spanning more than [--] years Speakman and colleagues show that total energy expenditure in humans has declined over time while adjusted physical activity energy expenditure has increased over time" [X Link](https://www.nature.com/articles/s42255-023-00782-2) 2023-04-26T00:00Z 2.1M followers, 12.6K engagements "Variant of the lactase LCT gene explains association between milk intake and incident type [--] diabetes Nature Metabolism Higher milk intake is associated with lower type [--] diabetes risk in lactase non-persistent individuals partly through gut microbiome and blood metabolites" [X Link](https://www.nature.com/articles/s42255-023-00961-1) 2024-01-23T00:25Z 208.1M followers, 16.7K engagements "Metabolic variation reflects dietary exposure in a multi-ethnic Asian population Nature Metabolism In a large multi-ethnic Asian cohort associations between over [----] plasma metabolites and specific foods and beverages are made. These dietmetabolite relationships were used to accurately predict clinical phenotypes such as diabetes and hypertension" [X Link](https://www.nature.com/articles/s42255-025-01359-x) 2025-09-18T06:58Z 208.1M followers, [---] engagements "Pivotal role of exogenous pyruvate in human natural killer cell metabolism - Nature Metabolism Kern Coquillat et al. show that NK cells rely on exogenous pyruvate import to support effector functions" [X Link](https://www.nature.com/articles/s42255-024-01188-4) 2025-01-03T00:00Z 2.6M followers, [----] engagements "Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase - Nature Metabolism OCarroll and Peace et al. provide a mechanism for the induction of type I interferons by the immunomodulatory compound itaconate which involves inhibition of succinate dehydrogenase and release of mitochondrial double-stranded RNA" [X Link](https://www.nature.com/articles/s42255-024-01145-1) 2024-10-15T00:00Z 71.9K followers, [----] engagements "Cancer cachexia: multilevel metabolic dysfunction - Nature Metabolism In this Review the authors highlight cancer cachexia as a complex and multifactorial disorder and discuss the underlying host-driven and tumour-driven metabolic changes therapeutic opportunities and the pertinent challenges in the treatment of cancer cachexia" [X Link](https://www.nature.com/articles/s42255-024-01167-9) 2024-11-22T00:00Z 228.6M followers, [----] engagements "Cysteine depletion triggers adipose tissue thermogenesis and weight loss Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans" [X Link](https://www.nature.com/articles/s42255-025-01297-8) 2025-06-07T03:41Z 208.1M followers, [--] engagements "The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases Nature Metabolism The authors introduce the Neurolipid Atlas a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease" [X Link](https://www.nature.com/articles/s42255-025-01365-z) 2025-09-22T10:50Z 208.1M followers, [----] engagements "Broad-spectrum antibiotics disrupt homeostatic efferocytosis - Nature Metabolism Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocytosis efficiency in vivo" [X Link](https://www.nature.com/articles/s42255-024-01107-7) 2024-08-09T00:00Z 208.1M followers, [--] engagements "Ketogenic diet reshapes cancer metabolism through lysine -hydroxybutyrylation - Nature Metabolism Multi-omics analysis of mouse livers shows that protein -hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified" [X Link](https://www.nature.com/articles/s42255-024-01093-w) 2024-08-12T00:00Z 208.1M followers, [----] engagements "Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD Nature Metabolism Feng Luo and colleagues show that the combination of glucose and fructose as found in sugar-sweetened beverages promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD)" [X Link](https://www.nature.com/articles/s42255-025-01368-w) 2025-09-19T16:57Z 228.6M followers, 46.2K engagements "Global neuronal or cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity Nature Metabolism In male mice with diet-induced obesity deletion of insulin inhibitory receptor (inceptor) in the whole body in the brain and in pancreatic β cells improves glucose homeostasis underlining a role of inceptor in regulating glucose homeostasis in the brain and pancreas" [X Link](https://www.nature.com/articles/s42255-024-00991-3) 2024-03-21T14:53Z 208.1M followers, [---] engagements "Shaping the future of cardiometabolic innovation: advances and opportunities Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks" [X Link](https://www.nature.com/articles/s42255-025-01343-5) 2025-08-26T17:13Z 2.1M followers, [----] engagements "Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism De Solis and Del Ro-Martn et al. investigate the reciprocal interplay between AgRP and POMC neurocircuits that governs the precise regulation of food intake and systemic metabolic homeostasis" [X Link](https://www.nature.com/articles/s42255-024-00987-z) 2024-02-20T00:00Z 72.4K followers, [----] engagements "DDHD2 provides a flux of saturated fatty acids for neuronal energy and function Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production proteostasis and membrane trafficking balance" [X Link](https://www.nature.com/articles/s42255-025-01367-x) 2025-09-30T18:11Z 228.6M followers, [----] engagements "Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism Long-acting GIPR agonists individually or as part of GIPRGLP-1R co-agonists are shown to require GIPR signaling in inhibitory GABAergic neurons to decrease body weight and food intake in mice" [X Link](https://www.nature.com/articles/s42255-023-00931-7) 2023-11-09T00:00Z 208.1M followers, [----] engagements "The elusive NMN transporter is found - Nature Metabolism Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors such as nicotinamide mononucleotide (NMN) represent an exciting area of research in aging and age-related diseases. A study in Nature Metabol" [X Link](https://www.nature.com/articles/s42255-018-0015-6) 2019-01-07T00:00Z 71.9K followers, [----] engagements "Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and -hydroxybutyrylome Nature Metabolism In the context of parental or diet-induced obesity preweaning ketosis contributes to improved health outcomes particularly by regulating the histone acetylome and β-hydroxybutyrylome for transcriptional activation of beige fat biogenesis genes" [X Link](https://www.nature.com/articles/s42255-025-01378-8) 2025-10-17T14:14Z 208.1M followers, [----] engagements "The source of dietary fat influences anti-tumour immunity in obese mice Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice whereas plant-based high-fat diets do not" [X Link](https://www.nature.com/articles/s42255-025-01330-w) 2025-09-04T17:17Z 2.1M followers, [----] engagements "AI-READI: rethinking AI data collection preparation and sharing in diabetes research and beyond - Nature Metabolism Here we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type [--] diabetes mellitus" [X Link](https://www.nature.com/articles/s42255-024-01165-x) 2024-11-08T00:00Z 71.1K followers, [--] engagements "Online now Enzyme engineering to fight mitochondrial diseases http://dlvr.it/RQCtXv http://dlvr.it/RQCtXv" [X Link](https://x.com/NatMetabolism/status/1229475373752020992) 2020-02-17T18:39Z 71.1K followers, [---] engagements "Online now NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD http://dlvr.it/RYDXvD http://dlvr.it/RYDXvD" [X Link](https://x.com/NatMetabolism/status/1270045185150349317) 2020-06-08T17:29Z 70.9K followers, [--] engagements "#NatMetabPicks In @NatureCellBio led by Song & Luo (Wuhan University): An intracellular transport pathway of LDL/LDL receptor from the plasma membrane bypasses lysosomes and delivers #cholesterol to #mitochondria for steroidogenesis. https://www.nature.com/articles/s41556-023-01160-6 https://www.nature.com/articles/s41556-023-01160-6" [X Link](https://x.com/NatMetabolism/status/1678772380322152448) 2023-07-11T14:25Z 71.6K followers, [----] engagements "Online now Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition" [X Link](https://x.com/NatMetabolism/status/1680970629514940417) 2023-07-18T02:34Z 61.4K followers, 10.4K engagements "#NatMetabPicks In @Cell_Metabolism led by @PerriLab (@Cambridge_Uni): The IGF2 peptide expressed by the placenta is required for the mother to adapt her glucose and lipid handling to support fetal growth in mice" [X Link](https://x.com/NatMetabolism/status/1688567422406811648) 2023-08-07T15:07Z 60.8K followers, [----] engagements "Online now Brain regulation of gastric dysfunction induced by stress" [X Link](https://x.com/NatMetabolism/status/1692205167033328001) 2023-08-17T16:02Z 61.5K followers, 12.2K engagements "RESEARCH Led by Sam Klein (@WUSTLmed): #Exercise together with diet-induced weight loss causes greater improvement in whole-body insulin sensitivity than matched diet-induced weight loss alone in people with obesity & prediabetes. 🏈🎾🏐" [X Link](https://x.com/anyuser/status/1693551010508071314) 2023-08-21T09:10Z [--] followers, 12.1K engagements "Online now Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth http://dlvr.it/SvHsvy http://dlvr.it/SvHsvy" [X Link](https://x.com/NatMetabolism/status/1696217725008494770) 2023-08-28T17:46Z 71.1K followers, 10.9K engagements "REVIEW Herbert Tilg & cols. (@imed_tweets) explore how metabolic dysfunction altered gut #microbiome & dysregulated innate & adaptive #Immunity contribute to #NAFLD highlighting how these factors mediate disease progression. #tbt" [X Link](https://x.com/NatMetabolism/status/1699801698087420256) 2023-09-07T15:08Z 61.5K followers, [----] engagements "RESEARCH Morant-Ferrando Jimenez-Blasco et al. (@ibfg_es): Astrocytic FA oxidation is needed to keep a specific configuration of the ETC enabling controlled production of ROS that fine-tune neuronglia metabolic coupling & support cognitive function" [X Link](https://x.com/NatMetabolism/status/1701280522561851566) 2023-09-11T17:04Z 61.4K followers, [----] engagements "RESEARCH Vande Voorde et al. (@CRUK_BI): Authors investigate the potential of untargeted #metabolomics as a stratification tool for colorectal cancer & present a pipeline to uncover metabolic vulnerabilities based on its genetic origin #cancerresearch" [X Link](https://x.com/NatMetabolism/status/1701570057531215917) 2023-09-12T12:14Z 60.8K followers, [----] engagements "PERSPECTIVE @XinnanwangL & @GulcinPekkurnaz (@Stanford @UCSDNeuro) offer an integrative overview on how mitochondrial homeostasis & diversity contribute to meeting specific cellular demands focusing on #neurons. #TBT 🔙" [X Link](https://x.com/NatMetabolism/status/1702271723440160987) 2023-09-14T10:43Z 61.4K followers, [----] engagements "RESEARCH Hanssen et al. (@UniCologne): Associative learning is reduced when metabolic sensing is impaired in obesity & can be restored by #liraglutide" [X Link](https://x.com/NatMetabolism/status/1702666429059756095) 2023-09-15T12:51Z 59.1K followers, [----] engagements "NEWS & VIEWS Swadha Mishra et al. (@UniBonn): Impaired TCA cycle & oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation & contribute to axonal degeneration in multiple sclerosis. #neurotwitter" [X Link](https://x.com/NatMetabolism/status/1703768663814263025) 2023-09-18T13:51Z 61.4K followers, [----] engagements "NEWS & VIEWS Mishra et al. (@UniBonn): Impaired TCA cycle & oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation & contribute to axonal degeneration in multiple sclerosis. #neurotwitter" [X Link](https://x.com/NatMetabolism/status/1703773293033955718) 2023-09-18T14:09Z 58.5K followers, [----] engagements "NEWS & VIEWS Dong & Hill (@UTSWNews): Heart failure-associated metabolic derangement results in cardiomyocyte #cholesterol overload & accumulation of bile acid intermediates triggering mitochondrial damage & #inflammation promoting heart failure ❣" [X Link](https://x.com/NatMetabolism/status/1704123773190799839) 2023-09-19T13:22Z 61.4K followers, [----] engagements "NEWS & VIEWS Lisa Beutler (@NUFeinbergMed): The author discusses a paper from our pages investigating a descending neural circuit that regulates gastric motility & is inversely modulated by chronic vs. acute #stress 🧠⚡🐭 #NeuroTwitter" [X Link](https://x.com/NatMetabolism/status/1709578982801166424) 2023-10-04T14:39Z 61.4K followers, [----] engagements "RESEARCH Dong et al. (Univ Sci Tech Hefei CN): The authors uncover a brain-to-stomach signaling axis that communicates gastric dysfunction associated with #stress ⚡🐭" [X Link](https://x.com/NatMetabolism/status/1710281309120020568) 2023-10-06T13:10Z 61.4K followers, [----] engagements "#NatMetabPicks In @NatureMicrobiol led by M. Desai (Luxembourg Institute of Health): The gut commensal Akkermansia muciniphila regulates #foodallergy symptoms in a diet-dependent manner in mice. https://www.nature.com/articles/s41564-023-01464-1 https://www.nature.com/articles/s41564-023-01464-1" [X Link](https://x.com/NatMetabolism/status/1710301683673182274) 2023-10-06T14:31Z 70.9K followers, [----] engagements "COMMENT @lab_cota together w/ @Kam_Allard @G0ubz & @Carmelo_Quarta (@NCMagendie) raise awareness on how best to report food intake & body weight in rodent studies for the sake of quality & reproducibility of metabolic studies. #tbt 🐭+🍽" [X Link](https://x.com/NatMetabolism/status/1714961087102079010) 2023-10-19T11:06Z 61.4K followers, [----] engagements "Online now GLUT2 glucose and oxygen sensing in CD8+ T cells" [X Link](https://x.com/NatMetabolism/status/1717586934321803724) 2023-10-26T17:00Z 58.3K followers, 22.5K engagements "REVIEW From Zhou et al. (Shanghai Immune Therapy Inst @WeillCornell): Innate lymphoid cells (ILCs) are integral to the innate immune system. The authors discuss how ILCs are regulated by intrinsic & extrinsic pathways & how they contribute to disease" [X Link](https://x.com/NatMetabolism/status/1718222074747945052) 2023-10-28T11:04Z 58.5K followers, 19.9K engagements "RESEARCH Patrick Lundgren et al. (@PennMedicine): In response to transient cold exposure a distinct subpopulation of brown #adipocytes carries out a lipogenic response which enables improved thermogenic response to secondary cold exposure. ❄🔥❄🔥" [X Link](https://x.com/NatMetabolism/status/1724085214685614411) 2023-11-13T15:22Z 59.1K followers, [----] engagements "Online now Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells" [X Link](https://x.com/NatMetabolism/status/1724278883711877185) 2023-11-14T04:11Z 59.1K followers, 16.4K engagements "NEWS & VIEWS Xuemei Tong (Shanghai Jia Tong Univ Sch Med CN) comments on: GLUT2 is a critical regulator of CD8+ T cell metabolism & functions in response to glucose & oxygen availability" [X Link](https://x.com/NatMetabolism/status/1734952687022559680) 2023-12-13T15:05Z 59.7K followers, [----] engagements "RESEARCH Kovatcheva et al. (@IRBBarcelona): Vitamin B12 improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation" [X Link](https://x.com/NatMetabolism/status/1737145324085395669) 2023-12-19T16:18Z 59.9K followers, [----] engagements "Online now Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance" [X Link](https://x.com/NatMetabolism/status/1744348257361490423) 2024-01-08T13:20Z 60.8K followers, [----] engagements "Online now Paracrine signalling by pancreatic cells determines the glycaemic set point in mice" [X Link](https://x.com/NatMetabolism/status/1744705227767566660) 2024-01-09T12:58Z 60.8K followers, 14.6K engagements "RESEARCH Linder Bernasocchi et al. (@harvardmed): The authors show how cancer cells reduce proline biosynthesis through P5CS to cope with glutamine starvation. #CancerResearch" [X Link](https://x.com/NatMetabolism/status/1744723023998115911) 2024-01-09T14:09Z 60.8K followers, [----] engagements "Our editor @YaninaPesch will attend the @KeystoneSymp Obesity: Causes and Consequences in Vancouver next week (Feb 4-7). Feel free to get in touch with her if you would like to chat about your work #KSObesity24" [X Link](https://x.com/NatMetabolism/status/1753097772289675751) 2024-02-01T16:47Z 61.5K followers, [----] engagements "CONSENSUS Reactive oxygen species are complex & difficult to measure. A group led by Murphy & Halliwell (@Cambridge_Uni @NUSingapore) proposes guidelines on ROS nomenclature & assessment in cells tissues & in vivo. #Throwbacks" [X Link](https://x.com/NatMetabolism/status/1757489091661169064) 2024-02-13T19:37Z 62K followers, [----] engagements "Online now A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism" [X Link](https://x.com/NatMetabolism/status/1759560497295438321) 2024-02-19T12:48Z 62.4K followers, 29.8K engagements "Online now Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism" [X Link](https://x.com/NatMetabolism/status/1759560514135535626) 2024-02-19T12:48Z 62.3K followers, [----] engagements "Online now A leucinemacrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets" [X Link](https://x.com/NatMetabolism/status/1759649946654155115) 2024-02-19T18:43Z 62.3K followers, 36.5K engagements "#RareDiseaseDay Led by S. Li @SchlisioSusanne (@karolinskainst) on von HippelLindau syndrome: The authors show how mitochondrial content is regulated in hypoxia and how this is impaired in cancers related to the von Hippel-Lindau syndrome" [X Link](https://x.com/NatMetabolism/status/1763174287182057901) 2024-02-29T12:08Z 62.7K followers, [----] engagements "#RareDiseaseDay V. Kagan et al. (U Pittsburgh) on Barth Syndrome: In Barth Syndrome altered accumulation of a cardiolipin derivative forms an anomalous peroxidase complex with cytochrome c contributing to lipid oxidation" [X Link](https://x.com/NatMetabolism/status/1763242142594400325) 2024-02-29T16:37Z 62.6K followers, [----] engagements "RESEARCH @khaledtigha @MarioPende et al. (@NeckerInem): Glycerol-3-phosphate & phosphoethanolamine accumulate in cells & rewire lipid #metabolism to promote #senescence" [X Link](https://x.com/NatMetabolism/status/1772257255955567087) 2024-03-25T13:40Z 63.6K followers, [----] engagements "RESEARCH @AnitaReddy1 @SallyWinther @echouchani et al. (@DanaFarber): The directionality of succinate transport across membranes is coupled with metabolic flux-derived changes in pH gradients. https://www.nature.com/articles/s42255-024-00981-5 https://www.nature.com/articles/s42255-024-00981-5" [X Link](https://x.com/NatMetabolism/status/1783514207817781520) 2024-04-25T15:11Z 64.5K followers, [----] engagements "REVIEW Measurements of oxygen consumption rates are central to study metabolism. Divakaruni & @MartinJastroch (@UCLA @Stockholms_univ) provide a guide advising on the selection of models instrumentation analysis & data interpretation. https://www.nature.com/articles/s42255-022-00619-4 https://www.nature.com/articles/s42255-022-00619-4" [X Link](https://x.com/NatMetabolism/status/1786128102571102379) 2024-05-02T20:18Z 64.8K followers, 17.7K engagements "RESEARCH @skxiao_nju @longlabstanford et al. (@StanfordPath): #Metformin triggers production & release of Lac-Phe from the gut which is required for its effects on food intake & weight loss. ⚕💊 https://www.nature.com/articles/s42255-024-00999-9 https://www.nature.com/articles/s42255-024-00999-9" [X Link](https://x.com/NatMetabolism/status/1787503074300277029) 2024-05-06T15:21Z 64.9K followers, [----] engagements "#NatMetabPicks In @emboournal by @JohannesMeiser and @FrezzaLab (@LIH_Luxembourg @CECAD_): The authors provide a guideline for biologists on how to best present metabolomics data https://www.embopress.org/doi/full/10.1038/s44318-024-00098-1 https://www.embopress.org/doi/full/10.1038/s44318-024-00098-1" [X Link](https://x.com/NatMetabolism/status/1787850710639358318) 2024-05-07T14:23Z 64.9K followers, [----] engagements "NEWS & VIEWS @DrBenjaminHorne (@Intermountain) The authors describe distinct phases of adaptations in the plasma proteome to seven days without food in humans & identify limited associations of protein changes with weight loss. https://www.nature.com/articles/s42255-024-01012-z https://www.nature.com/articles/s42255-024-01012-z" [X Link](https://x.com/NatMetabolism/status/1791121038132068841) 2024-05-16T14:58Z 65.2K followers, [----] engagements "Online now Glycolytic enzyme PFKL governs lipolysis by promoting lipid dropletmitochondria tethering to enhance -oxidation and tumor cell proliferation http://dlvr.it/T7BmG8 http://dlvr.it/T7BmG8" [X Link](https://x.com/NatMetabolism/status/1792937944325718105) 2024-05-21T15:18Z 67.3K followers, 23.5K engagements "Online now Time of exercise differentially impacts bone growth in mice http://dlvr.it/T7X5bQ http://dlvr.it/T7X5bQ" [X Link](https://x.com/NatMetabolism/status/1795617597230317692) 2024-05-29T00:46Z 65.5K followers, [----] engagements "NEWS & VIEWS Jamerson & Bradshaw (@etsu) Abundance of C. elegans BCAT-1 which catalyzes BCAA catabolism declines in aged worms but not in slowly aging mutants & stimulating BCAA catabolism extends reproductive #longevity 🪱 https://www.nature.com/articles/s42255-024-01009-8 https://www.nature.com/articles/s42255-024-01009-8" [X Link](https://x.com/NatMetabolism/status/1796158211252179206) 2024-05-30T12:34Z 76.5K followers, [----] engagements "#NatMetabPicks In @Nature led by @AmberAlhadeff (@Penn): The neural circuits in the hindbrain linking satiety and aversion are shown to be separate raising the possibility of developing #obesity drugs without the side effects of nausea and vomiting. https://www.nature.com/articles/s41586-024-07685-6 https://www.nature.com/articles/s41586-024-07685-6" [X Link](https://x.com/NatMetabolism/status/1814323073220218966) 2024-07-19T15:35Z 67.2K followers, [----] engagements "Online now H2S as a metabolic saboteur http://dlvr.it/T9qgmr http://dlvr.it/T9qgmr" [X Link](https://x.com/NatMetabolism/status/1814492450804977930) 2024-07-20T02:48Z 67.3K followers, [----] engagements "RESEARCH D. Xu Z. Lu et al. (@ZJU_China): Upon nutrient #stress in hepatocellular carcinoma the glycolytic enzyme PFKL facilitates mitochondria tethering to lipid droplets to engage lipid mobilization & ensure #nutrient supply ⚡ https://www.nature.com/articles/s42255-024-01047-2 https://www.nature.com/articles/s42255-024-01047-2" [X Link](https://x.com/NatMetabolism/status/1816825694325813672) 2024-07-26T13:19Z 67.7K followers, [----] engagements "RESEARCH C Jiang M Xu et al. (@PKU1898): TGR5 activation improves myocardial lipid accumulation & cardiac dysfunction in diabetic mice offering promise for managing diabetic cardiomyopathy 💓⚡ https://www.nature.com/articles/s42255-024-01036-5 https://www.nature.com/articles/s42255-024-01036-5" [X Link](https://x.com/NatMetabolism/status/1818267888823791970) 2024-07-30T12:50Z 67.7K followers, [----] engagements "RESEARCH L Lim L Adler @AyeletErez et al. (@WeizmannScience): The urea cycle enzyme ASS1 can function in the nucleus to supply fumarate necessary to drive DNA damage responses 🧬 https://www.nature.com/articles/s42255-024-01060-5 https://www.nature.com/articles/s42255-024-01060-5" [X Link](https://x.com/NatMetabolism/status/1824069875087609910) 2024-08-15T13:05Z 70.9K followers, [----] engagements "Online now A safety guide for transgenic Cre drivers in metabolism http://dlvr.it/TC7NK5 http://dlvr.it/TC7NK5" [X Link](https://x.com/NatMetabolism/status/1825787912254009811) 2024-08-20T06:52Z 70.9K followers, 18.7K engagements "#NatMetabPicks In @NatureMedicine led by E.L. Brittain (@VUMChealth): In a large cohort of patients whose sleep was monitored by a Fitbit over [---] yrs sleep stages duration and regularity were associated with chronic disease development 💤🛌 https://www.nature.com/articles/s41591-024-03155-8 https://www.nature.com/articles/s41591-024-03155-8" [X Link](https://x.com/NatMetabolism/status/1825920555167478002) 2024-08-20T15:39Z 70.9K followers, [----] engagements "FREE to read ✨ This authoritative piece lays a foundation for the field of #obesity research by comparing commonalities & differences between competing models of obesity pathogenesis defining terms that are at the core of the discussion. https://www.nature.com/articles/s42255-024-01106-8 https://www.nature.com/articles/s42255-024-01106-8" [X Link](https://x.com/NatMetabolism/status/1826962111450227181) 2024-08-23T12:38Z 70.8K followers, [----] engagements "RESEARCH Q Zhu PE Scherer et al. (@UTSWMedCenter): PAQR4 regulates cellular ceramide synthesis & accumulation to mediate adipose tissue function glucose homoeostasis & systemic metabolic health. https://www.nature.com/articles/s42255-024-01078-9 https://www.nature.com/articles/s42255-024-01078-9" [X Link](https://x.com/NatMetabolism/status/1828065298823422012) 2024-08-26T13:41Z 70.9K followers, [----] engagements "Online now The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade http://dlvr.it/TCRsrX http://dlvr.it/TCRsrX" [X Link](https://x.com/NatMetabolism/status/1828509583478022469) 2024-08-27T19:07Z 70.8K followers, [----] engagements "Online now Affinity war: PSAT1 outcompetes the rest http://dlvr.it/TCRstH http://dlvr.it/TCRstH" [X Link](https://x.com/NatMetabolism/status/1828509585302540422) 2024-08-27T19:07Z 70.9K followers, [----] engagements "NEWS&VIEWS @RichPossemato (@nyugrossman) Resistance to glutamine restriction is mediated by increased serine synthesis. The high affinity of serine synthesis enzyme PSAT1 for glutamate drives sustained glutamine utilization. https://www.nature.com/articles/s42255-024-01096-7 https://www.nature.com/articles/s42255-024-01096-7" [X Link](https://x.com/NatMetabolism/status/1834220671250928005) 2024-09-12T13:21Z 70.8K followers, [----] engagements "REVIEW Ctlina Cuparencu et al. (@uni_copenhagen) Here is an update on the most useful #biomarkers for assessing food intake which could help accelerate the application of biomarkers of food intake for improving human nutritional #research #diet 🍽 https://www.nature.com/articles/s42255-024-01067-y https://www.nature.com/articles/s42255-024-01067-y" [X Link](https://x.com/NatMetabolism/status/1834582344059039841) 2024-09-13T13:18Z 70.8K followers, [----] engagements "@uni_copenhagen Read it FREE here: https://rdcu.be/dTSX1 https://rdcu.be/dTSX1" [X Link](https://x.com/NatMetabolism/status/1834582502045847934) 2024-09-13T13:18Z 70.8K followers, [---] engagements "RESEARCH J McLaren @JasonGill74 et al. (@UofGlasgow): Modest weight gain leads to greater adverse metabolic consequences in South Asian compared to European men in part driven by differences in adipocyte morphology. #metabolism https://www.nature.com/articles/s42255-024-01101-z https://www.nature.com/articles/s42255-024-01101-z" [X Link](https://x.com/NatMetabolism/status/1838559020916826291) 2024-09-24T12:40Z 70.9K followers, [----] engagements "COMMENT @carla_horv @WolfrumLab Pelczar (@ETH_en @biozentrum) Despite widespread use of Cre driver lines several factors can affect experimental results and must be considered before embarking on Cre-based studies in #metabolicresearch 🐁🧬 https://www.nature.com/articles/s42255-024-01087-8 https://www.nature.com/articles/s42255-024-01087-8" [X Link](https://x.com/NatMetabolism/status/1839713354971025742) 2024-09-27T17:06Z 70.9K followers, [----] engagements "RESEARCH P Saavedra @JustinPerryPhD et al. (@MSKCancerCenter) Broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate rescues homeostatic efferocytosis efficiency in vivo. https://www.nature.com/articles/s42255-024-01107-7 https://www.nature.com/articles/s42255-024-01107-7" [X Link](https://x.com/NatMetabolism/status/1840750485596143659) 2024-09-30T13:48Z 70.9K followers, [----] engagements "RESEARCH Y He Y Xu et al. (@bcmhouston) The authors identify a neural population in the basal forebrain of mice that is key for maintaining #energy balance by facilitating homoeostatic feeding while suppressing hedonic #overeating. https://www.nature.com/articles/s42255-024-01099-4 https://www.nature.com/articles/s42255-024-01099-4" [X Link](https://x.com/NatMetabolism/status/1844401163325857799) 2024-10-10T15:34Z 70.5K followers, [----] engagements "NEWS&VIEWS Y Fu (@ASTARsg) Different subgroups of GABAergic neurons in mouse basal forebrain exert opposite impacts on food consumption highlighting the complex interaction of basal forebrain and hypothalamus for regulating feeding 🧠🍴. https://www.nature.com/articles/s42255-024-01111-x https://www.nature.com/articles/s42255-024-01111-x" [X Link](https://x.com/NatMetabolism/status/1844755343185723885) 2024-10-11T15:02Z 70.6K followers, [----] engagements "REVIEW Jens Juul Holst (@Metabolcenter) Dr. Holst reflects on the development of #GLP1 based drugs for the therapy of #obesity discussing #physiological #pharmacological and #clinical considerations related to their use.💉👥 https://www.nature.com/articles/s42255-024-01113-9 https://www.nature.com/articles/s42255-024-01113-9" [X Link](https://x.com/NatMetabolism/status/1853456375751340506) 2024-11-04T15:16Z 71.7K followers, [----] engagements "RESEARCH N Grankvist C Jnsson @roland_nilsson et al. (@karolinskainst): Grankvist et al. combine global isotopic tracing and #metabolic flux modelling to characterize metabolic networks in human intact #liver tissue🧪 https://www.nature.com/articles/s42255-024-01119-3 https://www.nature.com/articles/s42255-024-01119-3" [X Link](https://x.com/NatMetabolism/status/1856006885121339730) 2024-11-11T16:11Z 71.4K followers, [----] engagements "🔊Our editor @nakhle_j will be attending the ✨#MetabolismInAction24 ✨conference by @ScienceCluster in Hillerd Denmark. Reach out to him if you'd like to chat" [X Link](https://x.com/NatMetabolism/status/1856733763830493261) 2024-11-13T16:20Z 71.4K followers, [----] engagements "RESEARCH S OCarroll CG Peace @laoneill111 et al. (@tcddublin): Induction of type I interferons by the immunomodulatory compound itaconate involves inhibition of succinate dehydrogenase and release of mitochondrial double-stranded RNA. https://www.nature.com/articles/s42255-024-01145-1 https://www.nature.com/articles/s42255-024-01145-1" [X Link](https://x.com/NatMetabolism/status/1861447324821790951) 2024-11-26T16:30Z 71.9K followers, [----] engagements "NEWS & VIEWS T Cordes K Hiller (TU Braunschweig DE): #Itaconate-induced inhibition of succinate dehydrogenase regulates type [--] interferon production linking TCA cycle modulation to #antiviralresponses https://www.nature.com/articles/s42255-024-01146-0 https://www.nature.com/articles/s42255-024-01146-0" [X Link](https://x.com/NatMetabolism/status/1861745448278704561) 2024-11-27T12:14Z 71.8K followers, [----] engagements "NEWS & VIEWS @celineriera (@CedarsSinai) Capillary vessels become obstructed in diabetes leading to microvascular damage and cognitive defects. Such obstruction is independent of blood sugar but triggered by elevated IL-10. https://www.nature.com/articles/s42255-024-01161-1 https://www.nature.com/articles/s42255-024-01161-1" [X Link](https://x.com/NatMetabolism/status/1862507480150098214) 2024-11-29T14:42Z 71.9K followers, [----] engagements "RESEARCH MY Malik F Guo L Minichiello et al (@PharmOxford): Ntrk2/Trkb-mediated neurotrophic signalling regulates #dopamine levels by controlling glutathione-ascorbate #metabolism. 🧠🧫 https://www.nature.com/articles/s42255-024-01155-z https://www.nature.com/articles/s42255-024-01155-z" [X Link](https://x.com/NatMetabolism/status/1864708814630420783) 2024-12-05T16:30Z 72.1K followers, [----] engagements "Top altmetrics score 2024: #19🏆✨ @longlabstanford (@StanfordPath @Stanford_ChemH) and co-authors show that #metformin triggers release of Lac-Phe from the gut epithelium which is required for its effects on #foodintake and #weightloss 🍴💊 https://www.nature.com/articles/s42255-024-00999-9 https://www.nature.com/articles/s42255-024-00999-9" [X Link](https://x.com/NatMetabolism/status/1867660770231591169) 2024-12-13T20:00Z 72.3K followers, [----] engagements "Top citations 2024: # 17🏆✨ #Bettina Mittendorfer @RazaniLab (@washumedicine @pitt_medicine) and co-authors describe a leucine mediated threshold effect that regulates #macrophage mTOR signaling and #cardiovascular risk❤🩹 https://www.nature.com/articles/s42255-024-00984-2 https://www.nature.com/articles/s42255-024-00984-2" [X Link](https://x.com/NatMetabolism/status/1868325142289326159) 2024-12-15T16:00Z 72.3K followers, [----] engagements "Top citations 2024: #16🏆✨ @nielsgrarup @alexshauser @MM_Rosenkilde (@Metabolcenter @UCPH_health @GPCR_ucph) and co-authors describe genetic variants of #GIPR that highlight a contribution of beta-arrestin to metabolic phenotypes🧬👥 https://www.nature.com/articles/s42255-024-01061-4 https://www.nature.com/articles/s42255-024-01061-4" [X Link](https://x.com/NatMetabolism/status/1868687531186811022) 2024-12-16T16:00Z 72.3K followers, [----] engagements "Top altmetrics score 2024: #15🏆✨ X Hu RP Xiao (@PKU1898) and co-authors describe how tumor-derived lactate activates adipose GPR81 which leads to #cancer #cachexia. 👥🐭🧫 https://www.nature.com/articles/s42255-024-01011-0 https://www.nature.com/articles/s42255-024-01011-0" [X Link](https://x.com/NatMetabolism/status/1869110315700420959) 2024-12-17T20:00Z 72.4K followers, [----] engagements "Top citations 2024: #13🏆✨ Jens Brning (@MPI_Metabolism) and co-authors describe how reciprocal activity of #AgRP and #POMC neurons regulates #feeding and #metabolism.🧠🍽 https://www.nature.com/articles/s42255-024-00987-z https://www.nature.com/articles/s42255-024-00987-z" [X Link](https://x.com/NatMetabolism/status/1869774702178181449) 2024-12-19T16:00Z 72.5K followers, [----] engagements "Top citations 2024: #11🏆✨ Xinli Hu Rui-Ping Xiao (@PKU1898) and co-authors describe how activation of #GPR81 by #lactate drives tumour-induced #cachexia🐭👥🧫 https://www.nature.com/articles/s42255-024-01011-0 https://www.nature.com/articles/s42255-024-01011-0" [X Link](https://x.com/NatMetabolism/status/1870499476835631554) 2024-12-21T16:00Z 72.6K followers, [----] engagements "Top citations 2024: #10🏆✨ Yun-Stone Shi Qing Jiang Baosheng Guo (Nanjing Uni CN) and co-authors describe how osteocyte-derived #sclerostin affects #ageing and #Alzheimers disease progression.🦴🧠🧓 https://www.nature.com/articles/s42255-024-00989-x https://www.nature.com/articles/s42255-024-00989-x" [X Link](https://x.com/NatMetabolism/status/1870861858586145252) 2024-12-22T16:00Z 72.9K followers, [----] engagements "Top altmetrics score 2024: #8🏆✨ @Vinz_Sorrentino @FeigeLab (@NUSMedicine @EPFL) and co-authors identify trigonelline as a human metabolite that can be used for NAD+ synthesis and that improves #muscle function in #aging worms and mice 💪🐭 https://www.nature.com/articles/s42255-024-00997-x https://www.nature.com/articles/s42255-024-00997-x" [X Link](https://x.com/NatMetabolism/status/1871647037617525159) 2024-12-24T20:00Z 72.8K followers, [----] engagements "Top altmetrics score 2024: #7🏆✨ M Vniant (@Amgen) and co-authors report on a #GIPR agonist conjugated to GLP-1 analogues that reduces body weight and improves #metabolic markers in preclinical and phase [--] clinical settings 💊 https://www.nature.com/articles/s42255-023-00966-w https://www.nature.com/articles/s42255-023-00966-w" [X Link](https://x.com/NatMetabolism/status/1872009422614004223) 2024-12-25T20:00Z 73.1K followers, [----] engagements "Top citations 2024: #6🏆✨ @FeigeLab @Vinz_Sorrentino ( @EPFL @NUSingapore @NestleNHSc) and co-authors describe an #NAD+ precursor that improves #musclefunction during #ageing and is reduced in #human #sarcopenia👥💪 https://www.nature.com/articles/s42255-024-00997-x https://www.nature.com/articles/s42255-024-00997-x" [X Link](https://x.com/NatMetabolism/status/1872311413961560537) 2024-12-26T16:00Z 72.8K followers, [----] engagements "RESEARCH S Feng Na Xie P Feng et al. (@USC): The #NAD+ synthesis enzyme #NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase which restricts virion incorporation of viral proteins and underpins its #antiviral effect 🧫 https://www.nature.com/articles/s42255-024-01162-0 https://www.nature.com/articles/s42255-024-01162-0" [X Link](https://x.com/NatMetabolism/status/1872341614498074850) 2024-12-26T18:00Z 72.8K followers, [----] engagements "Top citations 2024: #4🏆✨ Sarah-Maria Fendt (@vib_ccb) and co-authors discuss the #metabolic #heterogeneity of #cancer in this Review Article 🐭👥 https://www.nature.com/articles/s42255-023-00963-z https://www.nature.com/articles/s42255-023-00963-z" [X Link](https://x.com/NatMetabolism/status/1873036191978930201) 2024-12-28T16:00Z 72.8K followers, 12K engagements "Top citations 2024: #3🏆✨🥉 @VidalPuig @DinaTiniakos @e_petsalaki P Davidsen J Perfield (@Cambridge_Uni @UniofNewcastle @emblebi @novonordisk @EliLillyandCo) and co-authors on ranking murine dietary models based on proximity to human #MASLD 🐭👥 https://www.nature.com/articles/s42255-024-01043-6 https://www.nature.com/articles/s42255-024-01043-6" [X Link](https://x.com/NatMetabolism/status/1873398576770154624) 2024-12-29T16:00Z 73.3K followers, 12.5K engagements "Top citations 2024: #2🏆✨🥈 Murielle M. Vniant Shu-Chen Lu (@Amgen) and co-authors describe the effects of a #GIPR antagonist conjugated to #GLP1 analogues on #weightloss and #metabolic parameters in preclinical and phase [--] settings🐭👥 https://www.nature.com/articles/s42255-023-00966-w https://www.nature.com/articles/s42255-023-00966-w" [X Link](https://x.com/NatMetabolism/status/1873760966368002073) 2024-12-30T16:00Z 73.1K followers, [----] engagements "RESEARCH AN Webster @michael_krashes JN Campbell et al. (Nat Inst of Diabetes and Digestive and Kidney Disease @UVA): A neural circuit through which GLP-1 receptor agonists suppress #appetite in mice is identified 🧠🍴🐁 https://www.nature.com/articles/s42255-024-01168-8 https://www.nature.com/articles/s42255-024-01168-8" [X Link](https://x.com/NatMetabolism/status/1873791159149224048) 2024-12-30T18:00Z 72.8K followers, [----] engagements "Top altmetrics score 2024: #1🏆✨🥇🎇 B Mittendorfer @RazaniLab (@PittTweet @WUSTL) describe how dietary leucine drives deleterious macrophage #mTORC1 signaling and promote #cardiovascular disease in humans and mice 🐭👥 https://www.nature.com/articles/s42255-024-00984-2 https://www.nature.com/articles/s42255-024-00984-2" [X Link](https://x.com/NatMetabolism/status/1874183751133257907) 2024-12-31T20:00Z 72.8K followers, 10.3K engagements "RESEARCH M Nam W Xia @RichPossemato et al. (@NYU @nyugrossman): Limited #glucose availability similar to the #tumor microenvironment confers resistance against chemotherapeutic drugs that target DNA synthesis 🧬💊 https://www.nature.com/articles/s42255-024-01166-w https://www.nature.com/articles/s42255-024-01166-w" [X Link](https://x.com/NatMetabolism/status/1874878324318646427) 2025-01-02T18:00Z 72.9K followers, [----] engagements "RESEARCH LE Hyland MR VanLinden M Niere @HeilandInes M Ziegler et al. (UiT_TAU NO; @BergenUib) #SubcellularNAD+ pools are interconnected with #mitochondria acting as a rheostat to maintain NAD+ levels upon excessive consumption🧫🔁 https://www.nature.com/articles/s42255-024-01174-w https://www.nature.com/articles/s42255-024-01174-w" [X Link](https://x.com/NatMetabolism/status/1877384847284474167) 2025-01-09T16:00Z 73.1K followers, [----] engagements "NEWS&VIEWS F Fitzpatrick and @KoryLab (@MET_HSPH) Subcellular #NAD+ pools are interconnected with #mitochondria acting as a buffer to maintain NAD+-dependent processes in overconsuming organelles. https://www.nature.com/articles/s42255-024-01160-2 https://www.nature.com/articles/s42255-024-01160-2" [X Link](https://x.com/NatMetabolism/status/1879932121126666264) 2025-01-16T16:41Z 73.2K followers, [----] engagements "#NatMetabPicks In @Cell_Metabolism led by C Kusminski et al. (@UTSWdiabetes): The #GIP receptor (#GIPR) activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive #weightloss in mice 🐁 https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00449-2 https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00449-2" [X Link](https://x.com/NatMetabolism/status/1882124569995046943) 2025-01-22T17:54Z 73.2K followers, [----] engagements "METABOLIC MESSENGERS Jerrold Olefsky Theresa Rohm and Karina Cunha e Rocha (@UCSanDiego) Concise overview of the role of small #ExtracellularVesicles (#EVs) in #metabolic health role as #biomarkers #mechanisms of action and #therapeutic potential. https://www.nature.com/articles/s42255-024-01214-5 https://www.nature.com/articles/s42255-024-01214-5" [X Link](https://x.com/NatMetabolism/status/1896654911833804863) 2025-03-03T20:12Z 74.8K followers, [----] engagements "#WorldObesityDay A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase [--] settings @WorldObesity @WorldObesityDay https://doi.org/10.1038/s42255-023-00966-w https://doi.org/10.1038/s42255-023-00966-w" [X Link](https://x.com/NatMetabolism/status/1896953790001025447) 2025-03-04T16:00Z 74.7K followers, [----] engagements Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing
@NatMetabolism Nature Metabolism
Nature Metabolism posts on X about weight loss, health, vivo, in the the most. They currently have [------] followers and [---] posts still getting attention that total [------] engagements in the last [--] hours.
Engagements: [------] #
- [--] Week [-----] -8.20%
- [--] Month [-------] -41%
- [--] Months [---------] +3,061%
- [--] Year [---------] +407%
Mentions: [--] #
- [--] Month [--] +18%
- [--] Months [---] +355%
- [--] Year [---] +144%
Followers: [------] #
- [--] Week [------] +0.17%
- [--] Month [------] +0.75%
- [--] Months [------] +5.40%
- [--] Year [------] +13%
CreatorRank: undefined #
Social Influence
Social category influence currencies travel destinations technology brands countries finance stocks formula 1 luxury brands automotive brands ncaa football
Social topic influence weight loss, health, vivo, in the, accumulation, $6963t, human, enzyme, ros, study
Top accounts mentioned or mentioned by @cambridgeuni @clemmensenc @cellmetabolism @harvardmed @pku1898 @amgen @unibonn @weillcornell @pennmedicine @nusingapore @karolinskainst @danafarber @ucla @longlabstanford @stanfordpath @johannesmeiser @lihluxembourg @cecad @nature @naturemedicine
Top assets mentioned Enzyme (MLN) GLP1 (GLP1) Flux (FLUX) XIAO (XIAO) Novartis AG (NVS)
Top Social Posts
Top posts by engagements in the last [--] hours
"Bile acid binds heart failure and inflammation - Nature Metabolism Mao et al. discover that heart failure-associated metabolic derangement results in cardiomyocyte cholesterol overload and accumulation of bile acid intermediates which in turn trigger mitochondrial damage and inflammatory activation and thus promote heart failure"
X Link 2023-07-13T00:00Z 70.9K followers, [---] engagements
"The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation - Nature Metabolism Nature Metabolism - The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation"
X Link 2024-06-25T00:00Z 72.4K followers, 19.7K engagements
"Time of sample collection is critical for the replicability of microbiome analyses Nature Metabolism Allaband et al. analyse how timing of sample collection affects the conclusions that can be drawn from microbiome studies which has implications for study design"
X Link 2025-04-03T05:09Z 228.6M followers, [--] engagements
"Gut microbiome pattern reflects healthy ageing and predicts survival in humans - Nature Metabolism Increasing compositional uniqueness of the gut microbiome and corresponding changes in microbial metabolites in the blood are identified as a signature of healthy ageing in humans"
X Link 2021-02-18T00:00Z 228.6M followers, 748K engagements
"Slc12a8 is a nicotinamide mononucleotide transporter Nature Metabolism Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter encoded by the Slc12a8 gene which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo"
X Link 2021-04-21T14:57Z 2.1M followers, 513.6K engagements
"PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels - Nature Metabolism PAQR4 regulates cellular ceramide synthesis and accumulation to mediate adipose tissue function glucose homoeostasis and thus systemic metabolic health"
X Link 2024-07-03T00:00Z 68.7K followers, [----] engagements
"Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection - Nature Metabolism Fiorina and colleagues document alterations in glucose metabolism in patients with COVID-19 and use continuous glucose monitoring to show that glycaemic abnormalities could still be detected [--] months after disease onset in patients who had recovered"
X Link 2021-05-25T00:00Z 208.1M followers, [---] engagements
"High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy Nature Metabolism Zhang et al. show that high-protein diets increase atherosclerosis risk through macrophage mTORC1 activation associated with suppressed clearance of damaged mitochondria and increased apoptosis"
X Link 2025-09-11T13:24Z 208.1M followers, [--] engagements
"Metabolic links among milk genes and gut Nature Metabolism Genotype at the LCT locus determines lactase expression and very notably varies across populations. Milk intake variably influences the aetiology of the risk of type [--] diabetes depending on ancestry. In this issue of Nature Metabolism Luo et al. describe how increased milk intake modifies both gut bacterial abundances and circulating metabolites in favour of decreasing the risk of type [--] diabetes in individuals who are lactase-deficient"
X Link 2024-01-23T00:25Z 208.1M followers, 16.7K engagements
"A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals Nature Metabolism The glucagon-like peptide [--] receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta) three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs"
X Link 2025-09-25T10:21Z 208.1M followers, [----] engagements
"Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study Nature Metabolism The SWEET project is a multicenter randomized controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity"
X Link 2025-10-07T10:16Z 2.1M followers, 179.9K engagements
"Towards nutrition with precision: unlocking biomarkers as dietary assessment tools - Nature Metabolism The authors provide an update on the most useful biomarkers in urine and blood for assessing food intake and delineate strategies that may accelerate the application of biomarkers of food intake for improving human nutritional research"
X Link 2024-07-02T00:00Z 70.9K followers, [----] engagements
"Short-term effects of high-protein lower-carbohydrate ultra-processed foods on human energy balance Nature Metabolism This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning"
X Link 2025-03-22T04:38Z 2.1M followers, 306.9K engagements
"The cyclic metabolic switching theory of intermittent fasting Nature Metabolism In this Perspective Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets"
X Link 2025-03-14T13:31Z 208.1M followers, [----] engagements
"Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution Nature Metabolism In this Review the authors present a roadmap towards achieving consensus on development analysis and interpretation of single-cell transcriptomics data in adipose tissue including discussion of roadblocks best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans"
X Link 2025-09-04T18:00Z 2.1M followers, [----] engagements
"ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response - Nature Metabolism Lim Adler et al. show that the urea cycle enzyme ASS1 can function in the nucleus to supply fumarate necessary to drive DNA damage responses"
X Link 2024-06-10T00:00Z 70.9K followers, [----] engagements
"A high-protein diet prevents weight regain Nature Metabolism Sustained weight loss and weight maintenance are key challenges for the treatment of obesity. Here the authors show that a high-protein diet following weight loss can protect against weight regain through a process dependent on the gut microbiome"
X Link 2024-09-03T17:10Z 208.1M followers, 11.7K engagements
"Natural killer loops: pyruvate in lactate out - Nature Metabolism Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate which regenerates cytosolic NAD+ via metabolism to lactate to support glycolysis and fuels oxidative phosphorylation via the mitochondrial citratemalate shuttle"
X Link 2025-01-03T00:00Z 72.7K followers, [---] engagements
"GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management - Nature Metabolism Holst reflects on the development of GLP-1-based drugs for the therapy of obesity from early observations to remarkable results in more recent clinical trials discussing physiological pharmacological and clinical considerations related to their use"
X Link 2024-08-19T00:00Z 228.6M followers, 13.4K engagements
"The metabolic and functional roles of sensory nerves in adipose tissues Nature Metabolism Mishra and Townsend present an overview of the regulation function and plasticity of adipose tissue sensory nerves that are relevant for metabolic processes in health and disease"
X Link 2025-09-09T15:06Z 208.1M followers, [----] engagements
"Cardiac glycosides are broad-spectrum senolytics - Nature Metabolism In addition to having direct anti-cancer effects the cardiac glycoside ouabain is shown to kill a broad range of senescent cells thus suggesting that cardiac glycosides represent a novel class of senolytics"
X Link 2019-10-21T00:00Z 72.5K followers, [---] engagements
"Itaconate modulates mitochondria for antiviral IFN- - Nature Metabolism Itaconate is an immunomodulatory metabolite that influences the outcome of infections and inflammatory diseases. New evidence indicates that itaconate-induced inhibition of succinate dehydrogenase regulates type [--] interferon production via the release of mitochondrial RNA linking TCA cycle modulation to antiviral interferon responses"
X Link 2024-10-15T00:00Z 71.8K followers, [----] engagements
"Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo - Nature Metabolism Grankvist et al. combine global isotopic tracing and metabolic flux modelling to characterize metabolic networks in human intact liver tissue"
X Link 2024-08-29T00:00Z 71.4K followers, [----] engagements
"Role and therapeutic potential of dietary ketone bodies in lymph vessel growth - Nature Metabolism Caused by a compromised lymphatic system lymphoedema leads to fluid retention and tissue swelling and is treated primarily with physical therapy. Here the authors present a metabolic approach to reduce lymphoedema by providing the ketone body -hydroxybutyrate or by feeding ketogenic diet which increases lymphangiogenesis and reduces fluid retention in mice"
X Link 2019-07-12T00:00Z 72.4K followers, [--] engagements
"Shooting for the stars: caspase-8meteorin in MASH and fibrosis Nature Metabolism In this issue of Nature Metabolism Wang et al. identified a non-apoptotic caspase-8 function in metabolic dysfunction-associated steatohepatitis (MASH) in which hepatocyte-derived caspase-8 induces meteorin which in turn activates hepatic stellate cells (HSCs) to drive fibrosis. This function reveals a potential therapeutic target to directly address fibrosis and reduce the progression of metabolic dysfunction-associated steatotic liver disease (MASLD)"
X Link 2025-09-27T08:04Z 208.1M followers, [---] engagements
"A safety guide for transgenic Cre drivers in metabolism - Nature Metabolism Despite the high utility and widespread use of Cre driver lines lack of Cre specificity Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research"
X Link 2024-08-19T00:00Z 208.1M followers, [----] engagements
"The metabolic roots of senescence: mechanisms and opportunities for intervention Nature Metabolism Wiley and Campisi discuss metabolic inducers of senescence and alterations in cellular metabolism associated with senescence while pointing out interventions that target metabolic processes to mitigate senescence"
X Link 2025-09-19T01:58Z 228.6M followers, [--] engagements
"Metabolic Messengers: small extracellular vesicles Nature Metabolism Olefsky Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history role as biomarkers mechanisms of action and therapeutic potential"
X Link 2025-02-08T13:15Z 2.1M followers, [----] engagements
"Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota Nature Metabolism Dietary methionine restriction has been reported to protect from cancer. Ji et al. describe a cancer-promoting effect of methionine restriction mediated by gut microbiota-induced sulfur deficiency and suppression of antitumour immunity"
X Link 2025-09-08T02:28Z 208.1M followers, [--] engagements
"Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging but was originally thought to be unattainable. However recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality thanks to the development of nano secondary ion mass spectrometry"
X Link 2023-09-07T00:00Z 70.9K followers, [----] engagements
"Impaired striatal glutathioneascorbate metabolism induces transient dopamine increase and motor dysfunction - Nature Metabolism Malik Guo et al. show that Ntrk2/Trkb-mediated neurotrophic signalling regulates dopamine levels by controlling glutathioneascorbate metabolism thus impacting striatal dopaminergic circuits and motor function"
X Link 2024-10-28T00:00Z 208.1M followers, [----] engagements
"Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation Nature Metabolism Xia et al. show that the activity of the small GTPase RalA is increased in white adipocytes in diet-induced obese mice. RalA enhances mitochondrial fission and therefore reduces energy expenditure which contributes to weight gain"
X Link 2024-03-31T13:04Z 2.1M followers, 36.2K engagements
"Why a good lab website matters - Nature Metabolism Lab websites are an important resource for making yourself known to the research community. Here we explain why having an informative up-to-date website can be a great tool for keeping the research community informed about your current projects"
X Link 2023-04-26T00:00Z 71.1K followers, 206.2K engagements
"Artificial intelligence in metabolic research Nature Metabolism The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint we asked [--] experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research"
X Link 2025-10-02T10:42Z 228.6M followers, 20.3K engagements
"Molecular control of endurance training adaptation in male mouse skeletal muscle - Nature Metabolism The authors explore the molecular signature of skeletal muscle adaptations to an acute bout of exercise in mice providing a valuable resource that includes transcriptomic epigenetic proteomic and phosphoproteomic changes in muscle plasticity"
X Link 2023-09-11T00:00Z 70.9K followers, 18.6K engagements
"NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD - Nature Metabolism Chronic obstructive pulmonary disease is a severe inflammatory lung disease characterized by obstructed airflow from the lungs. Here Seimetz et al. show that NADPH oxidase subunit [--] (NOXO1) is responsible for peroxynitrite formation from nitric oxide and superoxide and drives the development of smoke-induced emphysema and pulmonary hypertension"
X Link 2020-06-08T00:00Z 70.9K followers, [--] engagements
"Big data and personalized nutrition: the key evidence gaps Nature Metabolism The field of personalized nutrition hypothesizes that ‘big data’ — biological behavioural social and environmental — can be leveraged to make more precise and effective dietary recommendations to individuals for improving health outcomes compared to generic dietary advice. This article describes the research questions that need to be answered to understand whether personalized nutrition brings additional clinical utility"
X Link 2025-08-14T16:27Z 228.6M followers, [----] engagements
"Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights Nature Metabolism In a randomized crossover clinical trial in healthy young adults with varying weights sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motivation and somatosensory processing"
X Link 2025-03-26T19:05Z 2.1M followers, 253.3K engagements
"A short-term high-caloric diet has prolonged effects on brain insulin action in men Nature Metabolism Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men which outlasted the time-frame of overeating"
X Link 2025-02-28T22:06Z 228.6M followers, [----] engagements
"The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade - Nature Metabolism Qiu et al. provide insight into the metabolic adaptations that enable breast cancer cells to proliferate in the face of glutaminolysis blockade"
X Link 2024-08-27T00:00Z 70.9K followers, [--] engagements
"TrkB signalling regulates dopamine circuits and motor function through metabolic pathways - Nature Metabolism A common feature of neurodegenerative diseases is that select neuronal types are particularly sensitive to disease pathology at early stages. Altered TrkB signalling in the neuronal type most affected by Huntingtons disease increased expression of the enzyme GSTO2 leading to dopaminergic dysfunction impaired energy metabolism progressive degeneration and hyperkinetic symptoms"
X Link 2024-10-28T00:00Z 72.4K followers, [--] engagements
"Feeding gut microbes to nourish the brain: unravelling the dietmicrobiotagutbrain axis - Nature Metabolism This Review provides an overview of the interplay between host diet and the gut microbiota and how this affects brain function"
X Link 2024-08-22T00:00Z 208.1M followers, 44K engagements
"Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain Nature Metabolism A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors and are used to image receptor binding activities in tissues and animals"
X Link 2025-08-19T13:51Z 208.1M followers, [----] engagements
"Mapping biological influences on the human plasma proteome beyond the genome - Nature Metabolism The authors systematically study biological influences on the human plasma proteome in a large cohort thereby revealing causal associations between plasma proteins and modifiable risk factors for proteindisease associations"
X Link 2024-09-26T00:00Z 70.9K followers, [---] engagements
"Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice Nature Metabolism The intestinal symbiont Desulfovibrio which is enriched in individuals with metabolic syndrome is found to suppress the production of GLP-1 in male mice. The over-the-counter drug bismuth subsalicylate inhibits the effect of Desulfovibrio and restores GLP-1 levels"
X Link 2024-08-09T12:14Z 2.1M followers, 193.8K engagements
"Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21 Nature Metabolism Extended exposure to breastfeeding in rodent pups protects them from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This is mediated by liver-derived FGF21 signalling to the lateral hypothalamic area"
X Link 2022-08-16T15:54Z 208.1M followers, [--] engagements
"Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk - Nature Metabolism Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease"
X Link 2024-02-19T00:00Z 228.6M followers, 283.2K engagements
"Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type [--] diabetes risk - Nature Metabolism Dietary haem iron intake is linked with a higher type [--] diabetes risk. This dietary association is further supported by circulating metabolic and metabolomic biomarker data"
X Link 2024-08-13T00:00Z 208.1M followers, [--] engagements
"Mitochondrial transplants to treat mitochondrial dysfunction Nature Metabolism A new approach to treating mitochondrial disorders is based on the transplantation of healthy mitochondria and improves symptoms and survival in a mouse model of Leigh syndrome — a paediatric mitochondrial disease that is characterized by failure to thrive lactic acidosis and progressive degeneration"
X Link 2025-09-11T17:33Z 208.1M followers, [----] engagements
"Metagenomic estimation of dietary intake from human stool Nature Metabolism Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes"
X Link 2025-02-18T20:22Z 228.6M followers, [----] engagements
"Iron accumulation drives fibrosis senescence and the senescence-associated secretory phenotype - Nature Metabolism Iron is shown to have a central role in senescence both by triggering senescence and through its accumulation in senescent cells which is driving the senescence-associated secretory phenotype and in turn promotes fibrogenesis"
X Link 2023-12-14T00:00Z 70.9K followers, [---] engagements
"Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism Kovatcheva et al. show that vitamin B12 improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation"
X Link 2023-11-16T00:00Z 71.1K followers, [----] engagements
"Hindbrain circuits in the control of eating behaviour and energy balance - Nature Metabolism The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding as well as for the long-term control of body weight"
X Link 2022-07-25T00:00Z 70.9K followers, [--] engagements
"Molecular consequences of SARS-CoV-2 liver tropism Nature Metabolism Wanner et al. demonstrate SARS-CoV-2 liver tropism and identify transcriptional and proteomic profiles of SARS-CoV-2 liver samples that show similarities to previously characterized hepatotropic viruses"
X Link 2022-05-07T22:10Z 2.1M followers, [---] engagements
"Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages Nature Metabolism Senescent cells in fat and liver are shown to attract M1-like macrophages with increased expression of the NAD-consuming enzyme CD38 leading to their local accumulation and providing a mechanism for the age-associated decline in tissue NAD+ levels"
X Link 2021-03-07T15:13Z 2.1M followers, 46.1K engagements
"Dynamic lipidome alterations associated with human health disease and ageing - Nature Metabolism Longitudinal deep lipidome profiling reveals [---] lipid species many of which are associated with health-to-disease transitions in diabetes ageing and inflammation"
X Link 2023-09-11T00:00Z 70.9K followers, 44.6K engagements
"Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake Nature Metabolism Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription thereby coupling glucose uptake to organismal energy expenditure"
X Link 2025-09-14T18:45Z 208.1M followers, 22.4K engagements
"Metabolic heterogeneity in cancer - Nature Metabolism Demicco Liu et al. discuss how metabolic adaptations in cancer contribute to tumour progression. These adaptations entail high spatial and temporal metabolic heterogeneity based on local adaptations in different regions of the tumour microenvironment as well as metabolic evolution over time as the tumour progresses and metastasizes"
X Link 2024-01-24T00:00Z 72.7K followers, 12K engagements
"Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins - Nature Metabolism The NAD+ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase which restricts the virion incorporation of viral proteins and underpins its antiviral effect"
X Link 2024-11-21T00:00Z 72.7K followers, [----] engagements
"Activation of GPR81 by lactate drives tumour-induced cachexia - Nature Metabolism Tumour-derived lactate activates adipose GPR81 which in turn leads to cachexia. Targeting GPR81 and its downstream signalling pathway holds therapeutic potential for treating cancer cachexia"
X Link 2024-03-18T00:00Z 72.5K followers, [----] engagements
"Lac-Phe mediates the effects of metformin on food intake and body weight - Nature Metabolism Metformin is shown to trigger production and release of Lac-Phe from gut epithelial cells which is required for its effects on food intake and loss of body weight"
X Link 2024-03-18T00:00Z 72.3K followers, [----] engagements
"The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents"
X Link 2025-03-24T10:41Z 228.6M followers, [----] engagements
"Systemic proteome adaptions to 7-day complete caloric restriction in humans - Nature Metabolism The authors describe distinct phases of adaptions in the human plasma proteome to [--] days without food with profound changes occurring only after [--] days"
X Link 2024-03-01T00:00Z 2.1M followers, [----] engagements
"Metabolic Messengers: oestradiol Nature Metabolism Hevener and Correa provide a comprehensive overview of the preclinical and clinical evidence showing the metabolic role of oestradiol and its receptors in both women and men"
X Link 2025-07-27T00:28Z 208.1M followers, [----] engagements
"NAD+ precursor supplementation in human ageing: clinical evidence and challenges Nature Metabolism This Review summarizes existing data as well as crucial knowledge gaps emerging from clinical trials involving NAD+ precursor supplementation in humans"
X Link 2025-10-13T16:51Z 2.1M followers, 15K engagements
"Characterization of genetic variants of GIPR reveals a contribution of -arrestin to metabolic phenotypes - Nature Metabolism Molecular pharmacological characterization and association testing of human GIPR genetic variants with follow-up analysis in mice shows that -arrestins regulate GIPR signalling and thereby strongly contribute to metabolic outcomes"
X Link 2024-06-13T00:00Z 72.3K followers, [----] engagements
"Fructose stimulated de novo lipogenesis is promoted by inflammation - Nature Metabolism Fructose consumption has greatly increased in recent years and has been linked to the development of hepatic steatosis. Here the authors show that fructose promotes gut-barrier deterioration and subsequent endotoxaemia that in turn induces hepatic lipogenesis by activation TLR signalling in liver macrophages"
X Link 2020-08-24T00:00Z 72.3K followers, 73.3K engagements
"Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke Nature Metabolism Wang et al. report a workflow to perform quantitative mass spectrometry imaging and provide insight into spatial metabolic remodelling undergone in the mouse brain upon ischaemia"
X Link 2025-10-11T15:57Z 208.1M followers, [----] engagements
"Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals Nature Metabolism A new methodology uses intravital time-gated mid-infrared optoacoustic signals for accurate non-invasive measurements of glucose concentrations in blood-rich volumes of the skin"
X Link 2024-04-19T15:54Z 2.1M followers, [---] engagements
"GIPR-Ab/GLP-1 peptideantibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice Nature Metabolism This study together with a companion manuscript shows that in mice weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms"
X Link 2025-05-04T08:25Z 208.1M followers, [----] engagements
"Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota - Nature Metabolism In a randomized placebo-controlled trial in [--] individuals with excess body weight dietary supplementation with resistant starch lowers body weight and induces changes in gut microbiota composition. Mechanistic analysis in male mice shows that resistant starch at least partially facilitates weight loss through the action of Bifidobacterium adolescentis"
X Link 2024-02-26T00:00Z 208.1M followers, [--] engagements
"Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study - Nature Metabolism Modest weight gain leads to greater adverse metabolic consequences in South Asian compared to European men in part driven by differences in adipocyte morphology"
X Link 2024-08-16T00:00Z 70.9K followers, [----] engagements
"Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice Nature Metabolism This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake"
X Link 2025-10-11T09:00Z 62.3K followers, [--] engagements
"Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type [--] diabetes aetiology - Nature Metabolism In a genome-wide association study for traits related to pancreatic beta-cell function in [-----] individuals [--] independent associations mapping to [--] genetic loci are identified"
X Link 2024-10-17T00:00Z 208.1M followers, [----] engagements
"Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts which identify conserved as well as divergent metabolic patterns"
X Link 2025-08-03T17:31Z 208.1M followers, [----] engagements
"CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure Nature Metabolism This carefully designed study demonstrates that CagriSema overcomes metabolic adaptation in response to weight loss in rats"
X Link 2025-07-08T12:24Z 208.1M followers, [----] engagements
"A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type [--] diabetes - Nature Metabolism Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type [--] diabetes"
X Link 2024-11-04T00:00Z 71.1K followers, 41.3K engagements
"Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis - Nature Metabolism The authors uncover the role of cellular Feimin in regulating exercise performance by modulating SLN-mediated muscle thermogenesis"
X Link 2025-01-02T00:00Z 72.7K followers, [--] engagements
"Enzyme engineering to fight mitochondrial diseases - Nature Metabolism Inherited deficiencies in oxidative phosphorylation cause severe mitochondrial disease. A recent study in Nature Biotechnology demonstrates that an engineered bifunctional enzyme can rescue the biochemical consequences of mitochondrial dysfunction"
X Link 2020-02-17T00:00Z 70.9K followers, [--] engagements
"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction - Nature Metabolism The authors of this Perspective argue that the commonly used terms mitochondrial function and mitochondrial dysfunction do not do justice to the diverse mitochondrial features activities functions and behaviours within cells and thus call for the field to adopt more specific terminology in th"
X Link 2023-04-26T00:00Z 208.1M followers, 44.8K engagements
"Metabolic Messenger: growth differentiation factor [--] Nature Metabolism Breit and Tsai provide a concise overview of the role of GDF15 as a signalling molecule in the context of metabolic health and disease"
X Link 2025-10-07T16:00Z 2.1M followers, [----] engagements
"GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9 - Nature Metabolism Glucose-dependent insulinotropic polypeptide (GIP) is a gut incretin hormone released in response to nutrients. Here the authors report an anti-inflammatory and antiobesogenic mechanism of GIP by showing that loss of GIP receptor signalling in myeloid cells promotes pro-inflammatory S100A8/A9 release in adipose tissue"
X Link 2018-11-19T00:00Z 72.7K followers, [----] engagements
"Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA - Nature Metabolism The authors identify a role for GABRA5 neurons in the lateral hypothalamus for energy balance regulation. Inhibiting these neurons increases weight gain and lipid accumulation through a process dependent on astrocytic GABA release"
X Link 2023-08-31T00:00Z 70.9K followers, [----] engagements
"Ketogenesis activates metabolically protective T cells in visceral adipose tissue Nature Metabolism The ketogenic diet is a low-carbohydrate high-fat diet that forces a metabolic switch towards fatty acid oxidation. Here Goldberg et al. show that a ketogenic diet initially improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemic control during obesity"
X Link 2020-10-16T20:02Z 208.1M followers, 30.5K engagements
"Metabolic Messengers: bile acids - Nature Metabolism Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis"
X Link 2022-03-25T00:00Z 70.9K followers, [----] engagements
"Diabetes IL-10 and the brains microvascular crisis - Nature Metabolism A new study finds that capillary vessels become obstructed in diabetes and that their dysfunction may cause microvascular damage and lead to cognitive deficits. Such obstruction is independent of the elevated blood sugar found in diabetes and is triggered by elevated interleukin-10 cytokine signalling in cerebral blood vessel endothelial cells"
X Link 2024-11-04T00:00Z 71.9K followers, 46.5K engagements
"Central and peripheral GLP-1 systems independently suppress eating - Nature Metabolism GLP-1 is an incretin hormone and neuromodulator produced by gut enterocytes and CNS neurons. Brierley et al. find that GLP-1 from peripheral and central sources acts independently through distinct gutbrain circuits to suppress eating"
X Link 2021-02-15T00:00Z 68.7K followers, [---] engagements
"Total daily energy expenditure has declined over the past three decades due to declining basal expenditure not reduced activity expenditure - Nature Metabolism Using a database of doubly labelled water energy expenditure measurements spanning more than [--] years Speakman and colleagues show that total energy expenditure in humans has declined over time while adjusted physical activity energy expenditure has increased over time"
X Link 2023-04-26T00:00Z 2.1M followers, 12.6K engagements
"Variant of the lactase LCT gene explains association between milk intake and incident type [--] diabetes Nature Metabolism Higher milk intake is associated with lower type [--] diabetes risk in lactase non-persistent individuals partly through gut microbiome and blood metabolites"
X Link 2024-01-23T00:25Z 208.1M followers, 16.7K engagements
"Metabolic variation reflects dietary exposure in a multi-ethnic Asian population Nature Metabolism In a large multi-ethnic Asian cohort associations between over [----] plasma metabolites and specific foods and beverages are made. These dietmetabolite relationships were used to accurately predict clinical phenotypes such as diabetes and hypertension"
X Link 2025-09-18T06:58Z 208.1M followers, [---] engagements
"Pivotal role of exogenous pyruvate in human natural killer cell metabolism - Nature Metabolism Kern Coquillat et al. show that NK cells rely on exogenous pyruvate import to support effector functions"
X Link 2025-01-03T00:00Z 2.6M followers, [----] engagements
"Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase - Nature Metabolism OCarroll and Peace et al. provide a mechanism for the induction of type I interferons by the immunomodulatory compound itaconate which involves inhibition of succinate dehydrogenase and release of mitochondrial double-stranded RNA"
X Link 2024-10-15T00:00Z 71.9K followers, [----] engagements
"Cancer cachexia: multilevel metabolic dysfunction - Nature Metabolism In this Review the authors highlight cancer cachexia as a complex and multifactorial disorder and discuss the underlying host-driven and tumour-driven metabolic changes therapeutic opportunities and the pertinent challenges in the treatment of cancer cachexia"
X Link 2024-11-22T00:00Z 228.6M followers, [----] engagements
"Cysteine depletion triggers adipose tissue thermogenesis and weight loss Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans"
X Link 2025-06-07T03:41Z 208.1M followers, [--] engagements
"The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases Nature Metabolism The authors introduce the Neurolipid Atlas a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease"
X Link 2025-09-22T10:50Z 208.1M followers, [----] engagements
"Broad-spectrum antibiotics disrupt homeostatic efferocytosis - Nature Metabolism Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocytosis efficiency in vivo"
X Link 2024-08-09T00:00Z 208.1M followers, [--] engagements
"Ketogenic diet reshapes cancer metabolism through lysine -hydroxybutyrylation - Nature Metabolism Multi-omics analysis of mouse livers shows that protein -hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified"
X Link 2024-08-12T00:00Z 208.1M followers, [----] engagements
"Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD Nature Metabolism Feng Luo and colleagues show that the combination of glucose and fructose as found in sugar-sweetened beverages promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD)"
X Link 2025-09-19T16:57Z 228.6M followers, 46.2K engagements
"Global neuronal or cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity Nature Metabolism In male mice with diet-induced obesity deletion of insulin inhibitory receptor (inceptor) in the whole body in the brain and in pancreatic β cells improves glucose homeostasis underlining a role of inceptor in regulating glucose homeostasis in the brain and pancreas"
X Link 2024-03-21T14:53Z 208.1M followers, [---] engagements
"Shaping the future of cardiometabolic innovation: advances and opportunities Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks"
X Link 2025-08-26T17:13Z 2.1M followers, [----] engagements
"Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism De Solis and Del Ro-Martn et al. investigate the reciprocal interplay between AgRP and POMC neurocircuits that governs the precise regulation of food intake and systemic metabolic homeostasis"
X Link 2024-02-20T00:00Z 72.4K followers, [----] engagements
"DDHD2 provides a flux of saturated fatty acids for neuronal energy and function Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production proteostasis and membrane trafficking balance"
X Link 2025-09-30T18:11Z 228.6M followers, [----] engagements
"Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice - Nature Metabolism Long-acting GIPR agonists individually or as part of GIPRGLP-1R co-agonists are shown to require GIPR signaling in inhibitory GABAergic neurons to decrease body weight and food intake in mice"
X Link 2023-11-09T00:00Z 208.1M followers, [----] engagements
"The elusive NMN transporter is found - Nature Metabolism Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors such as nicotinamide mononucleotide (NMN) represent an exciting area of research in aging and age-related diseases. A study in Nature Metabol"
X Link 2019-01-07T00:00Z 71.9K followers, [----] engagements
"Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and -hydroxybutyrylome Nature Metabolism In the context of parental or diet-induced obesity preweaning ketosis contributes to improved health outcomes particularly by regulating the histone acetylome and β-hydroxybutyrylome for transcriptional activation of beige fat biogenesis genes"
X Link 2025-10-17T14:14Z 208.1M followers, [----] engagements
"The source of dietary fat influences anti-tumour immunity in obese mice Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice whereas plant-based high-fat diets do not"
X Link 2025-09-04T17:17Z 2.1M followers, [----] engagements
"AI-READI: rethinking AI data collection preparation and sharing in diabetes research and beyond - Nature Metabolism Here we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type [--] diabetes mellitus"
X Link 2024-11-08T00:00Z 71.1K followers, [--] engagements
"Online now Enzyme engineering to fight mitochondrial diseases http://dlvr.it/RQCtXv http://dlvr.it/RQCtXv"
X Link 2020-02-17T18:39Z 71.1K followers, [---] engagements
"Online now NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD http://dlvr.it/RYDXvD http://dlvr.it/RYDXvD"
X Link 2020-06-08T17:29Z 70.9K followers, [--] engagements
"#NatMetabPicks In @NatureCellBio led by Song & Luo (Wuhan University): An intracellular transport pathway of LDL/LDL receptor from the plasma membrane bypasses lysosomes and delivers #cholesterol to #mitochondria for steroidogenesis. https://www.nature.com/articles/s41556-023-01160-6 https://www.nature.com/articles/s41556-023-01160-6"
X Link 2023-07-11T14:25Z 71.6K followers, [----] engagements
"Online now Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition"
X Link 2023-07-18T02:34Z 61.4K followers, 10.4K engagements
"#NatMetabPicks In @Cell_Metabolism led by @PerriLab (@Cambridge_Uni): The IGF2 peptide expressed by the placenta is required for the mother to adapt her glucose and lipid handling to support fetal growth in mice"
X Link 2023-08-07T15:07Z 60.8K followers, [----] engagements
"Online now Brain regulation of gastric dysfunction induced by stress"
X Link 2023-08-17T16:02Z 61.5K followers, 12.2K engagements
"RESEARCH Led by Sam Klein (@WUSTLmed): #Exercise together with diet-induced weight loss causes greater improvement in whole-body insulin sensitivity than matched diet-induced weight loss alone in people with obesity & prediabetes. 🏈🎾🏐"
X Link 2023-08-21T09:10Z [--] followers, 12.1K engagements
"Online now Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth http://dlvr.it/SvHsvy http://dlvr.it/SvHsvy"
X Link 2023-08-28T17:46Z 71.1K followers, 10.9K engagements
"REVIEW Herbert Tilg & cols. (@imed_tweets) explore how metabolic dysfunction altered gut #microbiome & dysregulated innate & adaptive #Immunity contribute to #NAFLD highlighting how these factors mediate disease progression. #tbt"
X Link 2023-09-07T15:08Z 61.5K followers, [----] engagements
"RESEARCH Morant-Ferrando Jimenez-Blasco et al. (@ibfg_es): Astrocytic FA oxidation is needed to keep a specific configuration of the ETC enabling controlled production of ROS that fine-tune neuronglia metabolic coupling & support cognitive function"
X Link 2023-09-11T17:04Z 61.4K followers, [----] engagements
"RESEARCH Vande Voorde et al. (@CRUK_BI): Authors investigate the potential of untargeted #metabolomics as a stratification tool for colorectal cancer & present a pipeline to uncover metabolic vulnerabilities based on its genetic origin #cancerresearch"
X Link 2023-09-12T12:14Z 60.8K followers, [----] engagements
"PERSPECTIVE @XinnanwangL & @GulcinPekkurnaz (@Stanford @UCSDNeuro) offer an integrative overview on how mitochondrial homeostasis & diversity contribute to meeting specific cellular demands focusing on #neurons. #TBT 🔙"
X Link 2023-09-14T10:43Z 61.4K followers, [----] engagements
"RESEARCH Hanssen et al. (@UniCologne): Associative learning is reduced when metabolic sensing is impaired in obesity & can be restored by #liraglutide"
X Link 2023-09-15T12:51Z 59.1K followers, [----] engagements
"NEWS & VIEWS Swadha Mishra et al. (@UniBonn): Impaired TCA cycle & oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation & contribute to axonal degeneration in multiple sclerosis. #neurotwitter"
X Link 2023-09-18T13:51Z 61.4K followers, [----] engagements
"NEWS & VIEWS Mishra et al. (@UniBonn): Impaired TCA cycle & oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation & contribute to axonal degeneration in multiple sclerosis. #neurotwitter"
X Link 2023-09-18T14:09Z 58.5K followers, [----] engagements
"NEWS & VIEWS Dong & Hill (@UTSWNews): Heart failure-associated metabolic derangement results in cardiomyocyte #cholesterol overload & accumulation of bile acid intermediates triggering mitochondrial damage & #inflammation promoting heart failure ❣"
X Link 2023-09-19T13:22Z 61.4K followers, [----] engagements
"NEWS & VIEWS Lisa Beutler (@NUFeinbergMed): The author discusses a paper from our pages investigating a descending neural circuit that regulates gastric motility & is inversely modulated by chronic vs. acute #stress 🧠⚡🐭 #NeuroTwitter"
X Link 2023-10-04T14:39Z 61.4K followers, [----] engagements
"RESEARCH Dong et al. (Univ Sci Tech Hefei CN): The authors uncover a brain-to-stomach signaling axis that communicates gastric dysfunction associated with #stress ⚡🐭"
X Link 2023-10-06T13:10Z 61.4K followers, [----] engagements
"#NatMetabPicks In @NatureMicrobiol led by M. Desai (Luxembourg Institute of Health): The gut commensal Akkermansia muciniphila regulates #foodallergy symptoms in a diet-dependent manner in mice. https://www.nature.com/articles/s41564-023-01464-1 https://www.nature.com/articles/s41564-023-01464-1"
X Link 2023-10-06T14:31Z 70.9K followers, [----] engagements
"COMMENT @lab_cota together w/ @Kam_Allard @G0ubz & @Carmelo_Quarta (@NCMagendie) raise awareness on how best to report food intake & body weight in rodent studies for the sake of quality & reproducibility of metabolic studies. #tbt 🐭+🍽"
X Link 2023-10-19T11:06Z 61.4K followers, [----] engagements
"Online now GLUT2 glucose and oxygen sensing in CD8+ T cells"
X Link 2023-10-26T17:00Z 58.3K followers, 22.5K engagements
"REVIEW From Zhou et al. (Shanghai Immune Therapy Inst @WeillCornell): Innate lymphoid cells (ILCs) are integral to the innate immune system. The authors discuss how ILCs are regulated by intrinsic & extrinsic pathways & how they contribute to disease"
X Link 2023-10-28T11:04Z 58.5K followers, 19.9K engagements
"RESEARCH Patrick Lundgren et al. (@PennMedicine): In response to transient cold exposure a distinct subpopulation of brown #adipocytes carries out a lipogenic response which enables improved thermogenic response to secondary cold exposure. ❄🔥❄🔥"
X Link 2023-11-13T15:22Z 59.1K followers, [----] engagements
"Online now Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells"
X Link 2023-11-14T04:11Z 59.1K followers, 16.4K engagements
"NEWS & VIEWS Xuemei Tong (Shanghai Jia Tong Univ Sch Med CN) comments on: GLUT2 is a critical regulator of CD8+ T cell metabolism & functions in response to glucose & oxygen availability"
X Link 2023-12-13T15:05Z 59.7K followers, [----] engagements
"RESEARCH Kovatcheva et al. (@IRBBarcelona): Vitamin B12 improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation"
X Link 2023-12-19T16:18Z 59.9K followers, [----] engagements
"Online now Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance"
X Link 2024-01-08T13:20Z 60.8K followers, [----] engagements
"Online now Paracrine signalling by pancreatic cells determines the glycaemic set point in mice"
X Link 2024-01-09T12:58Z 60.8K followers, 14.6K engagements
"RESEARCH Linder Bernasocchi et al. (@harvardmed): The authors show how cancer cells reduce proline biosynthesis through P5CS to cope with glutamine starvation. #CancerResearch"
X Link 2024-01-09T14:09Z 60.8K followers, [----] engagements
"Our editor @YaninaPesch will attend the @KeystoneSymp Obesity: Causes and Consequences in Vancouver next week (Feb 4-7). Feel free to get in touch with her if you would like to chat about your work #KSObesity24"
X Link 2024-02-01T16:47Z 61.5K followers, [----] engagements
"CONSENSUS Reactive oxygen species are complex & difficult to measure. A group led by Murphy & Halliwell (@Cambridge_Uni @NUSingapore) proposes guidelines on ROS nomenclature & assessment in cells tissues & in vivo. #Throwbacks"
X Link 2024-02-13T19:37Z 62K followers, [----] engagements
"Online now A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism"
X Link 2024-02-19T12:48Z 62.4K followers, 29.8K engagements
"Online now Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism"
X Link 2024-02-19T12:48Z 62.3K followers, [----] engagements
"Online now A leucinemacrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets"
X Link 2024-02-19T18:43Z 62.3K followers, 36.5K engagements
"#RareDiseaseDay Led by S. Li @SchlisioSusanne (@karolinskainst) on von HippelLindau syndrome: The authors show how mitochondrial content is regulated in hypoxia and how this is impaired in cancers related to the von Hippel-Lindau syndrome"
X Link 2024-02-29T12:08Z 62.7K followers, [----] engagements
"#RareDiseaseDay V. Kagan et al. (U Pittsburgh) on Barth Syndrome: In Barth Syndrome altered accumulation of a cardiolipin derivative forms an anomalous peroxidase complex with cytochrome c contributing to lipid oxidation"
X Link 2024-02-29T16:37Z 62.6K followers, [----] engagements
"RESEARCH @khaledtigha @MarioPende et al. (@NeckerInem): Glycerol-3-phosphate & phosphoethanolamine accumulate in cells & rewire lipid #metabolism to promote #senescence"
X Link 2024-03-25T13:40Z 63.6K followers, [----] engagements
"RESEARCH @AnitaReddy1 @SallyWinther @echouchani et al. (@DanaFarber): The directionality of succinate transport across membranes is coupled with metabolic flux-derived changes in pH gradients. https://www.nature.com/articles/s42255-024-00981-5 https://www.nature.com/articles/s42255-024-00981-5"
X Link 2024-04-25T15:11Z 64.5K followers, [----] engagements
"REVIEW Measurements of oxygen consumption rates are central to study metabolism. Divakaruni & @MartinJastroch (@UCLA @Stockholms_univ) provide a guide advising on the selection of models instrumentation analysis & data interpretation. https://www.nature.com/articles/s42255-022-00619-4 https://www.nature.com/articles/s42255-022-00619-4"
X Link 2024-05-02T20:18Z 64.8K followers, 17.7K engagements
"RESEARCH @skxiao_nju @longlabstanford et al. (@StanfordPath): #Metformin triggers production & release of Lac-Phe from the gut which is required for its effects on food intake & weight loss. ⚕💊 https://www.nature.com/articles/s42255-024-00999-9 https://www.nature.com/articles/s42255-024-00999-9"
X Link 2024-05-06T15:21Z 64.9K followers, [----] engagements
"#NatMetabPicks In @emboournal by @JohannesMeiser and @FrezzaLab (@LIH_Luxembourg @CECAD_): The authors provide a guideline for biologists on how to best present metabolomics data https://www.embopress.org/doi/full/10.1038/s44318-024-00098-1 https://www.embopress.org/doi/full/10.1038/s44318-024-00098-1"
X Link 2024-05-07T14:23Z 64.9K followers, [----] engagements
"NEWS & VIEWS @DrBenjaminHorne (@Intermountain) The authors describe distinct phases of adaptations in the plasma proteome to seven days without food in humans & identify limited associations of protein changes with weight loss. https://www.nature.com/articles/s42255-024-01012-z https://www.nature.com/articles/s42255-024-01012-z"
X Link 2024-05-16T14:58Z 65.2K followers, [----] engagements
"Online now Glycolytic enzyme PFKL governs lipolysis by promoting lipid dropletmitochondria tethering to enhance -oxidation and tumor cell proliferation http://dlvr.it/T7BmG8 http://dlvr.it/T7BmG8"
X Link 2024-05-21T15:18Z 67.3K followers, 23.5K engagements
"Online now Time of exercise differentially impacts bone growth in mice http://dlvr.it/T7X5bQ http://dlvr.it/T7X5bQ"
X Link 2024-05-29T00:46Z 65.5K followers, [----] engagements
"NEWS & VIEWS Jamerson & Bradshaw (@etsu) Abundance of C. elegans BCAT-1 which catalyzes BCAA catabolism declines in aged worms but not in slowly aging mutants & stimulating BCAA catabolism extends reproductive #longevity 🪱 https://www.nature.com/articles/s42255-024-01009-8 https://www.nature.com/articles/s42255-024-01009-8"
X Link 2024-05-30T12:34Z 76.5K followers, [----] engagements
"#NatMetabPicks In @Nature led by @AmberAlhadeff (@Penn): The neural circuits in the hindbrain linking satiety and aversion are shown to be separate raising the possibility of developing #obesity drugs without the side effects of nausea and vomiting. https://www.nature.com/articles/s41586-024-07685-6 https://www.nature.com/articles/s41586-024-07685-6"
X Link 2024-07-19T15:35Z 67.2K followers, [----] engagements
"Online now H2S as a metabolic saboteur http://dlvr.it/T9qgmr http://dlvr.it/T9qgmr"
X Link 2024-07-20T02:48Z 67.3K followers, [----] engagements
"RESEARCH D. Xu Z. Lu et al. (@ZJU_China): Upon nutrient #stress in hepatocellular carcinoma the glycolytic enzyme PFKL facilitates mitochondria tethering to lipid droplets to engage lipid mobilization & ensure #nutrient supply ⚡ https://www.nature.com/articles/s42255-024-01047-2 https://www.nature.com/articles/s42255-024-01047-2"
X Link 2024-07-26T13:19Z 67.7K followers, [----] engagements
"RESEARCH C Jiang M Xu et al. (@PKU1898): TGR5 activation improves myocardial lipid accumulation & cardiac dysfunction in diabetic mice offering promise for managing diabetic cardiomyopathy 💓⚡ https://www.nature.com/articles/s42255-024-01036-5 https://www.nature.com/articles/s42255-024-01036-5"
X Link 2024-07-30T12:50Z 67.7K followers, [----] engagements
"RESEARCH L Lim L Adler @AyeletErez et al. (@WeizmannScience): The urea cycle enzyme ASS1 can function in the nucleus to supply fumarate necessary to drive DNA damage responses 🧬 https://www.nature.com/articles/s42255-024-01060-5 https://www.nature.com/articles/s42255-024-01060-5"
X Link 2024-08-15T13:05Z 70.9K followers, [----] engagements
"Online now A safety guide for transgenic Cre drivers in metabolism http://dlvr.it/TC7NK5 http://dlvr.it/TC7NK5"
X Link 2024-08-20T06:52Z 70.9K followers, 18.7K engagements
"#NatMetabPicks In @NatureMedicine led by E.L. Brittain (@VUMChealth): In a large cohort of patients whose sleep was monitored by a Fitbit over [---] yrs sleep stages duration and regularity were associated with chronic disease development 💤🛌 https://www.nature.com/articles/s41591-024-03155-8 https://www.nature.com/articles/s41591-024-03155-8"
X Link 2024-08-20T15:39Z 70.9K followers, [----] engagements
"FREE to read ✨ This authoritative piece lays a foundation for the field of #obesity research by comparing commonalities & differences between competing models of obesity pathogenesis defining terms that are at the core of the discussion. https://www.nature.com/articles/s42255-024-01106-8 https://www.nature.com/articles/s42255-024-01106-8"
X Link 2024-08-23T12:38Z 70.8K followers, [----] engagements
"RESEARCH Q Zhu PE Scherer et al. (@UTSWMedCenter): PAQR4 regulates cellular ceramide synthesis & accumulation to mediate adipose tissue function glucose homoeostasis & systemic metabolic health. https://www.nature.com/articles/s42255-024-01078-9 https://www.nature.com/articles/s42255-024-01078-9"
X Link 2024-08-26T13:41Z 70.9K followers, [----] engagements
"Online now The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade http://dlvr.it/TCRsrX http://dlvr.it/TCRsrX"
X Link 2024-08-27T19:07Z 70.8K followers, [----] engagements
"Online now Affinity war: PSAT1 outcompetes the rest http://dlvr.it/TCRstH http://dlvr.it/TCRstH"
X Link 2024-08-27T19:07Z 70.9K followers, [----] engagements
"NEWS&VIEWS @RichPossemato (@nyugrossman) Resistance to glutamine restriction is mediated by increased serine synthesis. The high affinity of serine synthesis enzyme PSAT1 for glutamate drives sustained glutamine utilization. https://www.nature.com/articles/s42255-024-01096-7 https://www.nature.com/articles/s42255-024-01096-7"
X Link 2024-09-12T13:21Z 70.8K followers, [----] engagements
"REVIEW Ctlina Cuparencu et al. (@uni_copenhagen) Here is an update on the most useful #biomarkers for assessing food intake which could help accelerate the application of biomarkers of food intake for improving human nutritional #research #diet 🍽 https://www.nature.com/articles/s42255-024-01067-y https://www.nature.com/articles/s42255-024-01067-y"
X Link 2024-09-13T13:18Z 70.8K followers, [----] engagements
"@uni_copenhagen Read it FREE here: https://rdcu.be/dTSX1 https://rdcu.be/dTSX1"
X Link 2024-09-13T13:18Z 70.8K followers, [---] engagements
"RESEARCH J McLaren @JasonGill74 et al. (@UofGlasgow): Modest weight gain leads to greater adverse metabolic consequences in South Asian compared to European men in part driven by differences in adipocyte morphology. #metabolism https://www.nature.com/articles/s42255-024-01101-z https://www.nature.com/articles/s42255-024-01101-z"
X Link 2024-09-24T12:40Z 70.9K followers, [----] engagements
"COMMENT @carla_horv @WolfrumLab Pelczar (@ETH_en @biozentrum) Despite widespread use of Cre driver lines several factors can affect experimental results and must be considered before embarking on Cre-based studies in #metabolicresearch 🐁🧬 https://www.nature.com/articles/s42255-024-01087-8 https://www.nature.com/articles/s42255-024-01087-8"
X Link 2024-09-27T17:06Z 70.9K followers, [----] engagements
"RESEARCH P Saavedra @JustinPerryPhD et al. (@MSKCancerCenter) Broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate rescues homeostatic efferocytosis efficiency in vivo. https://www.nature.com/articles/s42255-024-01107-7 https://www.nature.com/articles/s42255-024-01107-7"
X Link 2024-09-30T13:48Z 70.9K followers, [----] engagements
"RESEARCH Y He Y Xu et al. (@bcmhouston) The authors identify a neural population in the basal forebrain of mice that is key for maintaining #energy balance by facilitating homoeostatic feeding while suppressing hedonic #overeating. https://www.nature.com/articles/s42255-024-01099-4 https://www.nature.com/articles/s42255-024-01099-4"
X Link 2024-10-10T15:34Z 70.5K followers, [----] engagements
"NEWS&VIEWS Y Fu (@ASTARsg) Different subgroups of GABAergic neurons in mouse basal forebrain exert opposite impacts on food consumption highlighting the complex interaction of basal forebrain and hypothalamus for regulating feeding 🧠🍴. https://www.nature.com/articles/s42255-024-01111-x https://www.nature.com/articles/s42255-024-01111-x"
X Link 2024-10-11T15:02Z 70.6K followers, [----] engagements
"REVIEW Jens Juul Holst (@Metabolcenter) Dr. Holst reflects on the development of #GLP1 based drugs for the therapy of #obesity discussing #physiological #pharmacological and #clinical considerations related to their use.💉👥 https://www.nature.com/articles/s42255-024-01113-9 https://www.nature.com/articles/s42255-024-01113-9"
X Link 2024-11-04T15:16Z 71.7K followers, [----] engagements
"RESEARCH N Grankvist C Jnsson @roland_nilsson et al. (@karolinskainst): Grankvist et al. combine global isotopic tracing and #metabolic flux modelling to characterize metabolic networks in human intact #liver tissue🧪 https://www.nature.com/articles/s42255-024-01119-3 https://www.nature.com/articles/s42255-024-01119-3"
X Link 2024-11-11T16:11Z 71.4K followers, [----] engagements
"🔊Our editor @nakhle_j will be attending the ✨#MetabolismInAction24 ✨conference by @ScienceCluster in Hillerd Denmark. Reach out to him if you'd like to chat"
X Link 2024-11-13T16:20Z 71.4K followers, [----] engagements
"RESEARCH S OCarroll CG Peace @laoneill111 et al. (@tcddublin): Induction of type I interferons by the immunomodulatory compound itaconate involves inhibition of succinate dehydrogenase and release of mitochondrial double-stranded RNA. https://www.nature.com/articles/s42255-024-01145-1 https://www.nature.com/articles/s42255-024-01145-1"
X Link 2024-11-26T16:30Z 71.9K followers, [----] engagements
"NEWS & VIEWS T Cordes K Hiller (TU Braunschweig DE): #Itaconate-induced inhibition of succinate dehydrogenase regulates type [--] interferon production linking TCA cycle modulation to #antiviralresponses https://www.nature.com/articles/s42255-024-01146-0 https://www.nature.com/articles/s42255-024-01146-0"
X Link 2024-11-27T12:14Z 71.8K followers, [----] engagements
"NEWS & VIEWS @celineriera (@CedarsSinai) Capillary vessels become obstructed in diabetes leading to microvascular damage and cognitive defects. Such obstruction is independent of blood sugar but triggered by elevated IL-10. https://www.nature.com/articles/s42255-024-01161-1 https://www.nature.com/articles/s42255-024-01161-1"
X Link 2024-11-29T14:42Z 71.9K followers, [----] engagements
"RESEARCH MY Malik F Guo L Minichiello et al (@PharmOxford): Ntrk2/Trkb-mediated neurotrophic signalling regulates #dopamine levels by controlling glutathione-ascorbate #metabolism. 🧠🧫 https://www.nature.com/articles/s42255-024-01155-z https://www.nature.com/articles/s42255-024-01155-z"
X Link 2024-12-05T16:30Z 72.1K followers, [----] engagements
"Top altmetrics score 2024: #19🏆✨ @longlabstanford (@StanfordPath @Stanford_ChemH) and co-authors show that #metformin triggers release of Lac-Phe from the gut epithelium which is required for its effects on #foodintake and #weightloss 🍴💊 https://www.nature.com/articles/s42255-024-00999-9 https://www.nature.com/articles/s42255-024-00999-9"
X Link 2024-12-13T20:00Z 72.3K followers, [----] engagements
"Top citations 2024: # 17🏆✨ #Bettina Mittendorfer @RazaniLab (@washumedicine @pitt_medicine) and co-authors describe a leucine mediated threshold effect that regulates #macrophage mTOR signaling and #cardiovascular risk❤🩹 https://www.nature.com/articles/s42255-024-00984-2 https://www.nature.com/articles/s42255-024-00984-2"
X Link 2024-12-15T16:00Z 72.3K followers, [----] engagements
"Top citations 2024: #16🏆✨ @nielsgrarup @alexshauser @MM_Rosenkilde (@Metabolcenter @UCPH_health @GPCR_ucph) and co-authors describe genetic variants of #GIPR that highlight a contribution of beta-arrestin to metabolic phenotypes🧬👥 https://www.nature.com/articles/s42255-024-01061-4 https://www.nature.com/articles/s42255-024-01061-4"
X Link 2024-12-16T16:00Z 72.3K followers, [----] engagements
"Top altmetrics score 2024: #15🏆✨ X Hu RP Xiao (@PKU1898) and co-authors describe how tumor-derived lactate activates adipose GPR81 which leads to #cancer #cachexia. 👥🐭🧫 https://www.nature.com/articles/s42255-024-01011-0 https://www.nature.com/articles/s42255-024-01011-0"
X Link 2024-12-17T20:00Z 72.4K followers, [----] engagements
"Top citations 2024: #13🏆✨ Jens Brning (@MPI_Metabolism) and co-authors describe how reciprocal activity of #AgRP and #POMC neurons regulates #feeding and #metabolism.🧠🍽 https://www.nature.com/articles/s42255-024-00987-z https://www.nature.com/articles/s42255-024-00987-z"
X Link 2024-12-19T16:00Z 72.5K followers, [----] engagements
"Top citations 2024: #11🏆✨ Xinli Hu Rui-Ping Xiao (@PKU1898) and co-authors describe how activation of #GPR81 by #lactate drives tumour-induced #cachexia🐭👥🧫 https://www.nature.com/articles/s42255-024-01011-0 https://www.nature.com/articles/s42255-024-01011-0"
X Link 2024-12-21T16:00Z 72.6K followers, [----] engagements
"Top citations 2024: #10🏆✨ Yun-Stone Shi Qing Jiang Baosheng Guo (Nanjing Uni CN) and co-authors describe how osteocyte-derived #sclerostin affects #ageing and #Alzheimers disease progression.🦴🧠🧓 https://www.nature.com/articles/s42255-024-00989-x https://www.nature.com/articles/s42255-024-00989-x"
X Link 2024-12-22T16:00Z 72.9K followers, [----] engagements
"Top altmetrics score 2024: #8🏆✨ @Vinz_Sorrentino @FeigeLab (@NUSMedicine @EPFL) and co-authors identify trigonelline as a human metabolite that can be used for NAD+ synthesis and that improves #muscle function in #aging worms and mice 💪🐭 https://www.nature.com/articles/s42255-024-00997-x https://www.nature.com/articles/s42255-024-00997-x"
X Link 2024-12-24T20:00Z 72.8K followers, [----] engagements
"Top altmetrics score 2024: #7🏆✨ M Vniant (@Amgen) and co-authors report on a #GIPR agonist conjugated to GLP-1 analogues that reduces body weight and improves #metabolic markers in preclinical and phase [--] clinical settings 💊 https://www.nature.com/articles/s42255-023-00966-w https://www.nature.com/articles/s42255-023-00966-w"
X Link 2024-12-25T20:00Z 73.1K followers, [----] engagements
"Top citations 2024: #6🏆✨ @FeigeLab @Vinz_Sorrentino ( @EPFL @NUSingapore @NestleNHSc) and co-authors describe an #NAD+ precursor that improves #musclefunction during #ageing and is reduced in #human #sarcopenia👥💪 https://www.nature.com/articles/s42255-024-00997-x https://www.nature.com/articles/s42255-024-00997-x"
X Link 2024-12-26T16:00Z 72.8K followers, [----] engagements
"RESEARCH S Feng Na Xie P Feng et al. (@USC): The #NAD+ synthesis enzyme #NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase which restricts virion incorporation of viral proteins and underpins its #antiviral effect 🧫 https://www.nature.com/articles/s42255-024-01162-0 https://www.nature.com/articles/s42255-024-01162-0"
X Link 2024-12-26T18:00Z 72.8K followers, [----] engagements
"Top citations 2024: #4🏆✨ Sarah-Maria Fendt (@vib_ccb) and co-authors discuss the #metabolic #heterogeneity of #cancer in this Review Article 🐭👥 https://www.nature.com/articles/s42255-023-00963-z https://www.nature.com/articles/s42255-023-00963-z"
X Link 2024-12-28T16:00Z 72.8K followers, 12K engagements
"Top citations 2024: #3🏆✨🥉 @VidalPuig @DinaTiniakos @e_petsalaki P Davidsen J Perfield (@Cambridge_Uni @UniofNewcastle @emblebi @novonordisk @EliLillyandCo) and co-authors on ranking murine dietary models based on proximity to human #MASLD 🐭👥 https://www.nature.com/articles/s42255-024-01043-6 https://www.nature.com/articles/s42255-024-01043-6"
X Link 2024-12-29T16:00Z 73.3K followers, 12.5K engagements
"Top citations 2024: #2🏆✨🥈 Murielle M. Vniant Shu-Chen Lu (@Amgen) and co-authors describe the effects of a #GIPR antagonist conjugated to #GLP1 analogues on #weightloss and #metabolic parameters in preclinical and phase [--] settings🐭👥 https://www.nature.com/articles/s42255-023-00966-w https://www.nature.com/articles/s42255-023-00966-w"
X Link 2024-12-30T16:00Z 73.1K followers, [----] engagements
"RESEARCH AN Webster @michael_krashes JN Campbell et al. (Nat Inst of Diabetes and Digestive and Kidney Disease @UVA): A neural circuit through which GLP-1 receptor agonists suppress #appetite in mice is identified 🧠🍴🐁 https://www.nature.com/articles/s42255-024-01168-8 https://www.nature.com/articles/s42255-024-01168-8"
X Link 2024-12-30T18:00Z 72.8K followers, [----] engagements
"Top altmetrics score 2024: #1🏆✨🥇🎇 B Mittendorfer @RazaniLab (@PittTweet @WUSTL) describe how dietary leucine drives deleterious macrophage #mTORC1 signaling and promote #cardiovascular disease in humans and mice 🐭👥 https://www.nature.com/articles/s42255-024-00984-2 https://www.nature.com/articles/s42255-024-00984-2"
X Link 2024-12-31T20:00Z 72.8K followers, 10.3K engagements
"RESEARCH M Nam W Xia @RichPossemato et al. (@NYU @nyugrossman): Limited #glucose availability similar to the #tumor microenvironment confers resistance against chemotherapeutic drugs that target DNA synthesis 🧬💊 https://www.nature.com/articles/s42255-024-01166-w https://www.nature.com/articles/s42255-024-01166-w"
X Link 2025-01-02T18:00Z 72.9K followers, [----] engagements
"RESEARCH LE Hyland MR VanLinden M Niere @HeilandInes M Ziegler et al. (UiT_TAU NO; @BergenUib) #SubcellularNAD+ pools are interconnected with #mitochondria acting as a rheostat to maintain NAD+ levels upon excessive consumption🧫🔁 https://www.nature.com/articles/s42255-024-01174-w https://www.nature.com/articles/s42255-024-01174-w"
X Link 2025-01-09T16:00Z 73.1K followers, [----] engagements
"NEWS&VIEWS F Fitzpatrick and @KoryLab (@MET_HSPH) Subcellular #NAD+ pools are interconnected with #mitochondria acting as a buffer to maintain NAD+-dependent processes in overconsuming organelles. https://www.nature.com/articles/s42255-024-01160-2 https://www.nature.com/articles/s42255-024-01160-2"
X Link 2025-01-16T16:41Z 73.2K followers, [----] engagements
"#NatMetabPicks In @Cell_Metabolism led by C Kusminski et al. (@UTSWdiabetes): The #GIP receptor (#GIPR) activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive #weightloss in mice 🐁 https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00449-2 https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00449-2"
X Link 2025-01-22T17:54Z 73.2K followers, [----] engagements
"METABOLIC MESSENGERS Jerrold Olefsky Theresa Rohm and Karina Cunha e Rocha (@UCSanDiego) Concise overview of the role of small #ExtracellularVesicles (#EVs) in #metabolic health role as #biomarkers #mechanisms of action and #therapeutic potential. https://www.nature.com/articles/s42255-024-01214-5 https://www.nature.com/articles/s42255-024-01214-5"
X Link 2025-03-03T20:12Z 74.8K followers, [----] engagements
"#WorldObesityDay A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase [--] settings @WorldObesity @WorldObesityDay https://doi.org/10.1038/s42255-023-00966-w https://doi.org/10.1038/s42255-023-00966-w"
X Link 2025-03-04T16:00Z 74.7K followers, [----] engagements
Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing