[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.] [@suspendedJoey](/creator/twitter/suspendedJoey) "$nvo board shake-up screams stress response complete at odds with the culture that built them" [X Link](https://x.com/suspendedJoey/status/1980636419141038405) [@suspendedJoey](/creator/x/suspendedJoey) 2025-10-21T14:04Z 4490 followers, 2429 engagements "$xspray quite interesting case study in manufacturing CRL risk. late June the Co. announced a passed PAI "of the companys manufacturing lines" which was a major issue of the CRL last year. Yesterday another CRL was given but this time it relates" [X Link](https://x.com/suspendedJoey/status/1976192994660524140) [@suspendedJoey](/creator/x/suspendedJoey) 2025-10-09T07:48Z 4490 followers, 6277 engagements "How fast can $srpt recruit SRP-1005 (ARO-HTT / $arwr) In minipigs $qure achieved XX% lower mHTT in injected areas 30-50% in distal regions. $arwr in NHP brain XX% in striatum XX% temporal/frontal. We don't know translation to humans wrt brain-distribution/knockdown" [X Link](https://x.com/suspendedJoey/status/1981326503863595439) [@suspendedJoey](/creator/x/suspendedJoey) 2025-10-23T11:47Z 4490 followers, 2137 engagements "I wouldn't be surprised if ARP-1005 have an overall better distribution profile but let's assume they are similar in relevant areas for the sake of argument. SRP-1005 subcutaneous injection obvious first choice vs $qure intrathecal. Enrollment should be rapid. Run a ph1/2" [X Link](https://x.com/suspendedJoey/status/1981326505927143474) [@suspendedJoey](/creator/x/suspendedJoey) 2025-10-23T11:47Z 4490 followers, 1313 engagements "with 36m follow-up benchmark against a natural history cohort ( $srpt knows the drill basically can't fail lol) and file for AA" [X Link](https://x.com/suspendedJoey/status/1981326507868893381) [@suspendedJoey](/creator/x/suspendedJoey) 2025-10-23T11:47Z 4490 followers, 1597 engagements
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
@suspendedJoey
"$nvo board shake-up screams stress response complete at odds with the culture that built them"
X Link @suspendedJoey 2025-10-21T14:04Z 4490 followers, 2429 engagements
"$xspray quite interesting case study in manufacturing CRL risk. late June the Co. announced a passed PAI "of the companys manufacturing lines" which was a major issue of the CRL last year. Yesterday another CRL was given but this time it relates"
X Link @suspendedJoey 2025-10-09T07:48Z 4490 followers, 6277 engagements
"How fast can $srpt recruit SRP-1005 (ARO-HTT / $arwr) In minipigs $qure achieved XX% lower mHTT in injected areas 30-50% in distal regions. $arwr in NHP brain XX% in striatum XX% temporal/frontal. We don't know translation to humans wrt brain-distribution/knockdown"
X Link @suspendedJoey 2025-10-23T11:47Z 4490 followers, 2137 engagements
"I wouldn't be surprised if ARP-1005 have an overall better distribution profile but let's assume they are similar in relevant areas for the sake of argument. SRP-1005 subcutaneous injection obvious first choice vs $qure intrathecal. Enrollment should be rapid. Run a ph1/2"
X Link @suspendedJoey 2025-10-23T11:47Z 4490 followers, 1313 engagements
"with 36m follow-up benchmark against a natural history cohort ( $srpt knows the drill basically can't fail lol) and file for AA"
X Link @suspendedJoey 2025-10-23T11:47Z 4490 followers, 1597 engagements
/creator/twitter::938868707341819907/posts