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[@yusufhameed](/creator/twitter/yusufhameed)
"Sangamo's focus on hemophilia A complements the hemophilia B dominance of etranacogene dezaparvovec (Hemgenix uniQure/CSL) and fidanacogene elaparvovec (Beqvez Pfizer). It addresses a larger patient population (80% of hemophilia cases are type A) but faces challenges like FVIII expression durability (similar to Roctavian's decline over time) and AAV immunity exclusion (40% of patients). If partnered successfully giroctocogene could challenge Roctavian's market share with potentially more stable expression"  
[X Link](https://x.com/yusufhameed/status/1979097075275981068) [@yusufhameed](/creator/x/yusufhameed) 2025-10-17T08:08Z 1718 followers, XXX engagements


"Always a great sign when CFO of @Precigen $PGEN buying stock even after run up with FDA approval of Papzimeos @CathieDWood @jimcramer @cvpayne @JoeSquawk"  
[X Link](https://x.com/yusufhameed/status/1972245264716210620) [@yusufhameed](/creator/x/yusufhameed) 2025-09-28T10:21Z 1717 followers, XXX engagements


"Imagine waking up to this $SGMO shareholders wondering what you did wrong. $SPRB shorts so screwed. Enzyme replacement therapy is not the answer long term but what a ride @wallstreetbets @jimcramer @JoeSquawk $150M market cap today. $5M yesterday"  
[X Link](https://x.com/yusufhameed/status/1975488108583133432) [@yusufhameed](/creator/x/yusufhameed) 2025-10-07T09:07Z 1714 followers, 3534 engagements


"$PGEN Precigen reports durable responses to RRP treatment in long-term data. XX out of XX complete responders (83%) demonstrate continued complete response with median follow-up of XX months Reduction in surgeries compared to year prior to treatment with PAPZIMEOS was observed in XX% of patients in Year X XX% in Year X and XX% in Year 3"  
[X Link](https://x.com/yusufhameed/status/1977700121258156134) [@yusufhameed](/creator/x/yusufhameed) 2025-10-13T11:37Z 1717 followers, XXX engagements


"$SGMO $CRSP $EDIT $BEAM $NTLA $QURE $LLY $RHHBY $VRTX If and WHEN @SangamoTx secures a Fabry partnership deal find a suitable AI partner like @IsomorphicLabs @insitro. Biotech specialists like Isomorphic Labs or Insitro could edge out @OpenAI with deeper gene therapy expertise but OpenAI's scale shines for custom models. Weigh IP costs & pilots #BiotechAI #GeneTherapy"  
[X Link](https://x.com/yusufhameed/status/1978109751213887670) [@yusufhameed](/creator/x/yusufhameed) 2025-10-14T14:44Z 1717 followers, 2109 engagements


"$SGMO doing all the right things except announcing Fabry partnership. Pain studies could be a game changer. I would love to give an intrathecal injection for chronic pain patients that really works. $CRSP $EDIT $BEAM $NTLA $QURE $LLY $RHHBY $VRTX"  
[X Link](https://x.com/yusufhameed/status/1978178003134787801) [@yusufhameed](/creator/x/yusufhameed) 2025-10-14T19:16Z 1717 followers, 1847 engagements


"Job openings added to $SGMO over the last couple months. Not a sign of contracting. $CRSP $EDIT $BEAM $NTLA $QURE $PGEN $LLY $RHHBY $VRTX"  
[X Link](https://x.com/yusufhameed/status/1978190651863740540) [@yusufhameed](/creator/x/yusufhameed) 2025-10-14T20:06Z 1718 followers, 1497 engagements


"@AOC says it so it must be true @DeloitteUS pivots to manufacturing and poisons our waterways Interesting"  
[X Link](https://x.com/yusufhameed/status/1978962364234899578) [@yusufhameed](/creator/x/yusufhameed) 2025-10-16T23:12Z 1714 followers, XX engagements


"Gene therapy companies need a rethink $SGMO $CRSP $EDIT $BEAM $NTLA $PGEN $QURE $LLY $RHHBY $VRTX $TAK"  
[X Link](https://x.com/yusufhameed/status/1978933086478913845) [@yusufhameed](/creator/x/yusufhameed) 2025-10-16T21:16Z 1718 followers, 1241 engagements


"So was $PGEN until August have to follow the science. Gene therapy drugs works and we know $SGMO has good drug candidates. Biopharma deals happening weekly maybe Sangamo will find a suitor. Roche acquired 89bio for $XXX billion upfront (total potential up to $XXX billion) on September XX 2025 gaining access to pegozafermin an FGF21 analog in Phase X for metabolic dysfunction-associated steatohepatitis (MASH). Pfizer acquired Metsera for $XXX billion upfront (total potential up to $XXX billion including $XXX billion in CVRs) in September 2025 securing GLP-1 and amylin analog assets for obesity"  
[X Link](https://x.com/yusufhameed/status/1979243661599658294) [@yusufhameed](/creator/x/yusufhameed) 2025-10-17T17:50Z 1718 followers, 1915 engagements


"Lucy Martinez from Nathan Hale School in Chicago has Charlie Kirk Derangement Syndrome @TPUSA @chicagobulls @Cubs @ChicagoBears @NHLBlackhawks @chicagotribune @chicago @usedgov @ChicagosMayor"  
[X Link](https://x.com/yusufhameed/status/1979997212177297892) [@yusufhameed](/creator/x/yusufhameed) 2025-10-19T19:44Z 1718 followers, XXX engagements