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[@spontonic](/creator/twitter/spontonic)
""The anti-PD-1 moiety of JS207 adopts a Fab structure to maintain binding affinity to PD-1 and thereby attain better enrichment in the tumor microenvironment". at a cost of a little more tox than other anti-PD-1 Fabs"  
[X Link](https://x.com/spontonic/status/1979229400139993103) [@spontonic](/creator/x/spontonic) 2025-10-17T16:53Z XXX followers, XXX engagements


"@qniatof $BMY #CCR8 And relevant the "hell freezes over" trial completion date has been extended by X full years to 2028"  
[X Link](https://x.com/spontonic/status/1970642660340965868) [@spontonic](/creator/x/spontonic) 2025-09-24T00:13Z XXX followers, XXX engagements


"@qniatof 2/ could get a little weird. M.D. Anderson launching a phase II as $BMY extends its phase I by another X years is just more of the same. But I'm leaning toward LaNova Shionogi AND BMY being "go". Would be great to have a comparative handle on epitope definition"  
[X Link](https://x.com/spontonic/status/1970961202504401021) [@spontonic](/creator/x/spontonic) 2025-09-24T21:19Z XXX followers, XXX engagements


"#CCR8 Shimon Sakaguchi and the Nobel Prize in Physiology or Medicine 2025. among other accomplishments"  
[X Link](https://x.com/spontonic/status/1975304706726715424) [@spontonic](/creator/x/spontonic) 2025-10-06T20:58Z XXX followers, XXX engagements


"Anti-#CCR8 MAb S-531011 Shionogi"  
[X Link](https://x.com/spontonic/status/1975669459089326415) [@spontonic](/creator/x/spontonic) 2025-10-07T21:07Z XXX followers, XXX engagements


"Sort of figured. But of course AI agents do make mistakes and can't predict a future shaped by existing but unforeseen biology. Junshi attempting to use tori's own Fab to cut into its partner's sales"  
[X Link](https://x.com/spontonic/status/1979251392520032376) [@spontonic](/creator/x/spontonic) 2025-10-17T18:21Z XXX followers, XX engagements


"Amgen v. Sanofi: The 2023 Supreme Court ruling in Amgen v. Sanofi affirmed the need for patents to sufficiently enable the full scope of a claimed invention reinforcing the idea that broad speculative claims are not valid. By analogy a license"  
[X Link](https://x.com/spontonic/status/1979252764279792010) [@spontonic](/creator/x/spontonic) 2025-10-17T18:26Z XXX followers, XX engagements