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[@StephenVLiu](/creator/twitter/StephenVLiu)
"Be sure to join Drs. @EnriquetaFelip @LuisPaz_Ares and me at #ESMO25 on Saturday October XX 6:30pm in Hall XX as we discuss recent advances in #SCLC. Lots of emerging data to put together - join us for a lively discussion"  
[X Link](https://x.com/StephenVLiu/status/1977689136447603117) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-13T10:53Z 28.7K followers, 3177 engagements


"Dr. @JordiRemon at #BTGGlobalLung2025 leads a discussion on rare alterations. MTAP deletions now relevant with promising agents. #NRG1 fusions predict poor outcomes in NSCLC with standard therapies but zenocutuzumab now approved. STK11 mt - should we pursue dual checkpoint"  
[X Link](https://x.com/StephenVLiu/status/1978769464859521363) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-16T10:26Z 28.7K followers, 2192 engagements


"Impressive results from MDT-BRIDGE at #ESMO25 from Dr. @MartinReck2. Pts with resectable or borderline had X cycles of durvalumab + chemo then reassessed at MDT. If resectable at start XX% remained resectable. If borderline XX% were then felt to be resectable. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979450481400516850) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-18T07:32Z 28.7K followers, 19.6K engagements


"Nice perspective in discussion by Dr. @finn_corinne at #ESMO25 on SKYSCRAPER-03 where adding tiragolumab did not improve outcomes over standard PACIFIC and MDT-BRIDGE reassured by only X% of people not having either surgery or definitive chemoradiation. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979454294655906084) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-18T07:47Z 28.7K followers, 2158 engagements


"#ESMO25 Brain mets present in XX% of pts overall. For those with no brain metastases X% developed brain metastases as site of first progression. Studies ongoing (cohort G) in pts with measurable CNS disease to report CNS RR and intracranial PFS hopefully. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979814290392814079) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-19T07:38Z 28.7K followers, XX engagements


"We will face a shortage of oncologists as projected cancer cases rise and number of oncologists decreasing relative to demand. XX% of oncologists are 64y and older. Number of oncologists currently on pace to meet only XX% of demand in next XX years. Gaps will widen"  
[X Link](https://x.com/StephenVLiu/status/1975906472690331753) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-08T12:49Z 28.7K followers, 61.8K engagements


"Dr. @FedericoCappuz1 brilliantly presents updates and controversies for uncommon and exon XX EGFR mutations at #BTGGlobalLung2025. Amivantamab + chemotherapy is the 1L standard but new agents arriving may disrupt the paradigm. Need to watch toxicity resistance CNS efficacy"  
[X Link](https://x.com/StephenVLiu/status/1978459213757104143) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-15T13:53Z 28.7K followers, 2567 engagements


"Dr. @ZPiotrowskaMD discusses NORTHSTAR #ESMO25 - impressive PFS benefit in #EGFR NSCLC when local consolidation therapy added but notable heterogeneity. Pt selection important need uniform definitions biomarkers (radiomics). Encouraging results here. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979196961887502755) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-17T14:45Z 28.7K followers, 11.5K engagements


"#ESMO25 Safety notable for diarrhea in XX% of pts with XX% grade X. However in cohort D G3 diarrhea was XX% but in cohort F (treatment naive) G3 diarrhea was 5%. Could this reflect proximity to prior immunotherapy And no cases of pneumonitis. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979814293370790067) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-19T07:38Z 28.7K followers, XXX engagements


"#ESMO25 Included XX pts with HER2 TKD mt (66% YVMA) treated with 1L zongertinib 120mg - RR XX% DCR XX% () time to response 1.4m XX% still on treatment median DOR/PFS not reached 6m DOR XX% 6m PFS 79%. Impressive numbers here. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979819148491596017) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-19T07:57Z 28.7K followers, XXX engagements


"#ESMO25 Primary related toxicities are diarrhea seen in XX% (3% grade 3+) rash in XX% (no G3) and LFT elevation (AST XX% with X% G3 ALT XX% with X% G3). Dose reduction in XX% discontinuation due to AE in X% two cases of ILD noted (3% both grade 2). #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979819151607955829) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-19T07:57Z 28.7K followers, XX engagements


"Akeso reports Phase III HARMONi-A trial positive for survival. Ivonescimab (PD1/VEGF bispecific) + chemotherapy vs chemo in #EGFR NSCLC post TKI already showed PFS benefit (7.1m vs 4.8m) but OS was in question. Full results to be presented at #WCLC25"  
[X Link](https://x.com/StephenVLiu/status/1960957912748044313) [@StephenVLiu](/creator/x/StephenVLiu) 2025-08-28T06:49Z 28.6K followers, 4539 engagements


"Pooled analysis from ALTA-2 and J-ALTA @LungCaJournal by @TonyMok9 et al shows efficacy of brigatinib after alectinib in #ALK NSCLC: RR XX% DOR 9.2m PFS 5.2m OS 25m. PFS better if ctDNA negative (11 vs 3.5m)"  
[X Link](https://x.com/StephenVLiu/status/1976224129562144994) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-09T09:52Z 28.6K followers, 2148 engagements


"#ESMO25 Dr. Ying Liu will present abstract 1848MO results from the phaes II FURMO-003 study of firmonertinib (aka furmonertinib) in pts with previously treated EGFR exon XX NSCLC. ITT RR XXXX% DCR XX% DOR 8.3m PFS 8.3m OS 21.2m diarrhea in 64.8%. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1977732432959799772) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-13T13:45Z 28.7K followers, 2713 engagements


"#ESMO25 Dr. @Ilias_Houda presents 1851MO the PAULIEN trial: 1L pembro +/- chemo in PD-L1 high NSCLC. Stopped early for futility. RR at 6wks favored pembro/chemo (33% vs 23%) but no difference at 12wks (48% vs 47%). PFS HR XXXX OS HR XXXX. G3+ TRAE XX% vs 35%. #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1977734464936554509) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-13T13:53Z 28.6K followers, 2464 engagements


"PACIFIC-2 results @JCO_ASCO - while consolidation durvalumab after concurrent chemoradiation for NSCLC significantly improves PFS and OS simultaneous durvalumab + chemoradiation did not improve outcomes over CRT alone: PFS HR XXXX (ns) OS HR 1.03"  
[X Link](https://x.com/StephenVLiu/status/1978027920149934474) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-14T09:19Z 28.6K followers, 5100 engagements


"In patients receiving durvalumab for LS-SCLC after CRT who progress 6m after completing chemotherapy what do you recommend as next line therapy #BTGGlobalLung2025 #MJHLifeSciences @OncLive"  
[X Link](https://x.com/StephenVLiu/status/1978431100570448123) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-15T12:01Z 28.6K followers, 1614 engagements


"Dr. @HendriksLizza leads a discussion on neoadjuvant perioperative & adjuvant immunotherapy for early stage NSCLC at #BTGGlobalLung2025. Open questions on how PD-L1 and co-mutations should impact strategies and the role for consolidation IO after neoadjuvant. #MJHLifeSciences"  
[X Link](https://x.com/StephenVLiu/status/1978717520191201646) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-16T06:59Z 28.7K followers, 1714 engagements


"How do we approach neoadjuvant and perioperative immunotherapy in PD-L1 negative resectable NSCLC Dr. @FordePatrick reviews the data at #BTGGlobalLung2025 and raises key controversies. Some conflicting datasets suggest hidden biomarkers. Important to define exact benefit"  
[X Link](https://x.com/StephenVLiu/status/1978722373558837517) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-16T07:19Z 28.7K followers, 3017 engagements


"Dr. @LeXiuning reflects on #KRAS G12C NSCLC at #BTGGlobalLung2025. Sotorasib and adagrasib standard 2L - newer agents coming quickly and will be a race to see who (safely) enters 1L space with immunotherapy first. Other off inhibitors pan RAS inhibitors on the way"  
[X Link](https://x.com/StephenVLiu/status/1978754422801883483) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-16T09:26Z 28.7K followers, 2494 engagements


"Dr. @EnriquetaFelip discusses #ALK in NSCLC at #BTGGlobalLung2025. Many active TKIs with lorlatinib showing best efficacy to date - neladalkib (NVL-655) showing promise as next gen agent. Early stage use standard after ALINA - await update at #ESMO25"  
[X Link](https://x.com/StephenVLiu/status/1978758794160005206) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-16T09:43Z 28.7K followers, 2813 engagements


"#ESMO25 Dr. @MLJohnsonMD2 updates PHAROS: encorafenib + binimetinib in #BRAF V600E NSCLC. 1L RR XX% DOR 40m () PFS 30.4m OS 47.6m. Later line RR XX% DOR 16.7m PFS 9.3m OS 22.7m. Pyrexia in only X% main toxicities nausea diarrhea. Impressive update #ESMOAmbassadors"  
[X Link](https://x.com/StephenVLiu/status/1979886824547041281) [@StephenVLiu](/creator/x/StephenVLiu) 2025-10-19T12:26Z 28.7K followers, 6209 engagements