[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.] [@chuminhua432](/creator/twitter/chuminhua432) "$GSK announced that the NMPA has approved Shingrix (GSKs Recombinant Zoster Vaccine or RZV) for the prevention of shingles (herpes zoster) in adults aged XX years and over who are at increased risk of shingles due to immunodeficiency or immunosuppression caused by known disease or therapy. the previous indication for adults aged XX and older" [X Link](https://x.com/chuminhua432/status/1978399314906141153) [@chuminhua432](/creator/x/chuminhua432) 2025-10-15T09:55Z 2911 followers, XXX engagements "#esmo2025 RemeGen reported the Ph3 RC48-C016 study in Presidential Symposium its HER2 ADC disitamab vedotin (DV) + toripalimab ( Junshi's PD-1 mab) vs chemo as 1L HER2-expressing la/m urothelial carcinoma median PFS: XXXX months vs XXX months reducing the risk of disease progression or death by XX% (HR =0.36 XX% CI: XXXX - XXXX P 0.0001). median OS: XXXX months vs XXXX months XX% reduction in the risk of death (HR = XXXX XX% CI: XXXX - XXXX P 0.0001) ORR assessed by BICR: XXXX% vs 50.2%" [X Link](https://x.com/chuminhua432/status/1980461853500404011) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T02:31Z 2911 followers, 1873 engagements "Takeda $TAK has entered into a license and collaboration agreement with Innovent Biologics for two late-stage oncology medicines IBI363 and IBI343 worldwide outside of Greater China. IBI363 PD-1/IL-2-bias bispecific antibody fusion protein is being evaluated in NSCLC and CRC IBI343 a Claudin XXXX ADC is being evaluated in gastric and pancreatic cancers. Takeda will also receive an exclusive option to license global rights outside of Greater China for IBI3001 (EGFRB7H3 ADC) an early-stage investigational medicine. $XXX billion upfront $XXX million equity investment" [X Link](https://x.com/chuminhua432/status/1980824221568909429) [@chuminhua432](/creator/x/chuminhua432) 2025-10-22T02:31Z 2911 followers, 3477 engagements "$ONC and $ABBV s Pharmacyclics have decided to voluntarily dismiss the patent lawsuit the Big Pharma firm brought against its competitor over their BTK inhibitors. BeOne announced the decision in a securities filing to HKSE. The move comes after the U.S. Patent and Trademark Office (USPTO) recently invalidated all claims of AbbVies patent No. 11672803 which underpinned the Illinois pharmas patent infringement lawsuit filed in 2023" [X Link](https://x.com/chuminhua432/status/1974136578315595864) [@chuminhua432](/creator/x/chuminhua432) 2025-10-03T15:36Z 2911 followers, XXX engagements "#esmo2025 Kelun-Biotech TROP2 ADC sacituzumab tirumotecan (sac-TMT) which out-licensed to $MRK in 2022 for ex-Greater China rights Phase X OptiTROP-Lung04 trial: in EGFR-mutated NSCLC following progression on EGFR-TKIs receive sac-TMT monotherapy or chemotherapy median PFS of XXX months versus XXX months OS was not reached XX% lower risk of death" [X Link](https://x.com/chuminhua432/status/1980286505164915145) [@chuminhua432](/creator/x/chuminhua432) 2025-10-20T14:54Z 2911 followers, 1538 engagements "$ZLAB Zai Lab has registered its first Ph3 clinical trial of ZL-1310 (zocilurtatug pelitecan) This randomized open-label clinical trial (n=665) aims to evaluate the efficacy and safety of ZL-1310 (at two dose levels) compared with investigator's choice (Tarlatamab Topotecan Lurbinectedin or Amrubicin) in patients with relapsed SCLC. The primary endpoints are cORR and OS. ZL-1310 is an ADC targeting DLL3 discovered by MediLink Therapeutics using its TAMLIN technology platform. In April 2023 Zai Lab and MediLink Therapeutics entered an agreement acquiring global rights for ZL-1310. In ASCO2025" [X Link](https://x.com/chuminhua432/status/1980616444850368962) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T12:45Z 2911 followers, 3035 engagements "Chengdu Hyperway Pharmaceuticals clinical-stage startup specializing in brain-penetrant small molecule drug discovery and development announced the completion of its Series B financing exceeding RMB XXX million. This round was led by Huagai Capital. Hyperway was founded in 2019 with a focus on multiple therapeutic areas including oncology pain management and central nervous system disorders. X candidates in Phase 2: HBW-004285 (a non-addictive Nav1.8 inhibitor surpassing VX-548 in pharmacokinetics safety and onset speed) and HBW-3220 (a 4th generation BTK inhibitor overcoming drug" [X Link](https://x.com/chuminhua432/status/1980972581139460551) [@chuminhua432](/creator/x/chuminhua432) 2025-10-22T12:20Z 2911 followers, 1048 engagements "BeiGene $ONC Announces First Quarter 2025 Financial Results and Business Updates Q1 2025 total revenues increased XX% to$1.1 billionwith BRUKINSA(zanubrutinib) global sales increasing XX% to$792 millionon strong demand growth vs. Q1 2024 Advanced late-stage hematology and solid tumor pipelines with plan to host Investor R&D Day onJune XX Secured shareholder approval to rename the Company toBeOne Medicines Ltd.and redomicile toSwitzerland" [X Link](https://x.com/chuminhua432/status/1920124681019158739) [@chuminhua432](/creator/x/chuminhua432) 2025-05-07T14:32Z 2910 followers, XXX engagements "BeOne Medicines (BeiGene) $ONC has recently registered a Ph2 study (CTR20252981) on #CDE for its independently developed #IRAK4 PROTAC degrader BGB-45035 vs placebo in patients with moderate to severe active rheumatoid arthritis who have had an inadequate response to csDMARDs or bDMARDs/tsDMARDs. This is currently the only IRAK4 degrader drug in Phase II clinical trials globally. The primary clinical endpoint is the disease activity score based on C-reactive protein at Week XX. Other IRAK4 degrader in clinical trials: LT-002-158 Shanghai Leadingtac Pharma Ph1" [X Link](https://x.com/chuminhua432/status/1950454398578282866) [@chuminhua432](/creator/x/chuminhua432) 2025-07-30T07:12Z 2910 followers, 1308 engagements "#Akeso said in its H1 2025 report its lung cancer drug ivonescimab (PD-1/EGFR) for the first time clearly extended overall survival (OS) in a pivotal study. The final analysis of the Phase III HARMONi-A trial met its OS goal showing that ivonescimab delivered "a statistically significant and clinically meaningful OS benefit."" [X Link](https://x.com/chuminhua432/status/1960530603306311912) [@chuminhua432](/creator/x/chuminhua432) 2025-08-27T02:31Z 2910 followers, 9751 engagements "Kailera Therapeutics Announces $XXX Million Series B Financing Kailera Therapeutics details of which first emerged in May 2024 under the name Hercules CM NewCo emerged from stealth Tuesday with plans to develop a portfolio of GLP-1 drugs. The drugs were acquired from Jiangsu Hengrui Pharmaceuticals" [X Link](https://x.com/chuminhua432/status/1978392581731123206) [@chuminhua432](/creator/x/chuminhua432) 2025-10-15T09:28Z 2910 followers, 1042 engagements "1/ #Hansoh Pharmaceutical has registered a Phase 1b clinical trial for B7H3 ADC HS-20093 in combination with other treatments for osteosarcoma on" [X Link](https://x.com/chuminhua432/status/1860298053691015663) [@chuminhua432](/creator/x/chuminhua432) 2024-11-23T12:23Z 2911 followers, XXX engagements "#Innovent $IVBXF has registered a Ph2 clinical study to evaluate weekly subcutaneous injections of IBI362 (GLP-1R/GCGR dual-target agonist) in Chinese patients with heart failure with HFpEF or HFmrEF and obesity. NCT0686290" [X Link](https://x.com/chuminhua432/status/1897916105265643933) [@chuminhua432](/creator/x/chuminhua432) 2025-03-07T07:43Z 2911 followers, 3777 engagements "#3SBio published the Ph2 results of SSGJ-707 #SSGJ707 a bispecific antibody targeting PD-1 and VEGF as a monotherapy in patients with advanced NSCLC . Among the XX pts completed at least one efficacy evaluation ORR and DCR were XXXX% (8/27)/85.2% (23/27) 61.8%(21/34)97.1% (33/34) XXXX% (6/11)/90.9% (10/11) and XX% (1/4)/75% (3/4) at doses of 5mg/kg Q3W 10mg/kg Q3W 20mg/kg Q3W and XX mg/kg Q3W respectively. Select subgroups are summarized in SSGJ-707 10mg/kg Q3W. The ORR were XXXX% (12/22) and 75%(9/12) in non-squamous and squamous pts respectively" [X Link](https://x.com/chuminhua432/status/1925826076023882183) [@chuminhua432](/creator/x/chuminhua432) 2025-05-23T08:08Z 2911 followers, 12K engagements "On June XX #Innovent Biologics held its annual R&D Day event. Over its XX years since establishment Innovent has launched XX new drugs. In 2024 the company recorded revenue of RMB XXX billion. Focusing on oncology as its core therapeutic area Innovent is advancing its pipeline through next-generation IO therapies and next-generation ADCs. The core pipeline includes PD-1/IL-2 bispecific antibody #IBI363 while next-generation ADCs encompass dual-target ADCs and dual-toxin ADCs" [X Link](https://x.com/chuminhua432/status/1939569758237860062) [@chuminhua432](/creator/x/chuminhua432) 2025-06-30T06:20Z 2911 followers, 3081 engagements "Legend Biotech $LEGN registered a Phase I clinical trial for LUCAR-G19 to treat autoimmune diseases. NCT07049081 The study plans to enroll XX patients with relapsed or refractory autoimmune diseases including systemic lupus erythematosus systemic sclerosis ANCA-associated vasculitis inflammatory myopathy Takayasu arteritis IgG4-related disease. The study has X sites in #China. LUCAR is a non-gene-editing allogeneic CAR-T technology platform independently developed by Legend Biotech. It employs endogenous TCR silencing technology blocking complex formation by expressing proteins that" [X Link](https://x.com/chuminhua432/status/1941061396588069293) [@chuminhua432](/creator/x/chuminhua432) 2025-07-04T09:07Z 2911 followers, 2837 engagements "$PFE announced the completion of a global ex-China licensing agreement with 3SBio granting Pfizer exclusive rights for the development manufacturing and commercialization of 3SBios SSGJ-707 Additionally the agreement provides Pfizer the option to extend the license to include exclusive development and commercialization rights to SSGJ-707 in China. In exchange for the exclusive rights in China Pfizer will pay 3SBio up to $XXX million in option payments" [X Link](https://x.com/chuminhua432/status/1948752473646399903) [@chuminhua432](/creator/x/chuminhua432) 2025-07-25T14:29Z 2911 followers, XXX engagements "#NMPA CDE website #Innovent Biologics' PD-1/IL-2-bias bispecific antibody therapy #IBI363 has received clearance for two clinical trial applications. X as neoadjuvant therapy for non-squamous non-small cell lung cancer X IBI363 + bevacizumab for advanced solid tumor (EGFR+ advanced NSCLC platinum-resistant ovarian cancer). ASCO2025 IBI363 was featured in three oral presentations covering colorectal cancer melanoma and NSCLC. Previously Innovents PD-1 monoclonal antibody sintilimab + bevacizumab had already been approved in China for the treatment of locally advanced or metastatic non-squamous" [X Link](https://x.com/chuminhua432/status/1950135086218903827) [@chuminhua432](/creator/x/chuminhua432) 2025-07-29T10:03Z 2911 followers, XXX engagements "#Vigonvita submitted its Hong Kong IPO prospectus on January XX 2025 which expired after six months on July XX and was resubmitted on July 31" [X Link](https://x.com/chuminhua432/status/1951225545376801174) [@chuminhua432](/creator/x/chuminhua432) 2025-08-01T10:16Z 2911 followers, XXX engagements "#Innovent Biologics' U.S. subsidiary Fortvita Biologics has registered a Phase X clinical trial for the small-molecule GLP-1 receptor agonist #IBI3032 The Phase X trial plans to enroll XX healthy participants divided into X cohorts with each cohort consisting of X participants receiving IBI3032 or placebo in a 6:2. According to information disclosed by Innovent at this year's JPM IBI3032 is an oral small-molecule GLP-1 receptor agonist" [X Link](https://x.com/chuminhua432/status/1955980461236478199) [@chuminhua432](/creator/x/chuminhua432) 2025-08-14T13:10Z 2911 followers, 2038 engagements "#Innovent Biologics' clinical trial application for #IBI3026 has been accepted by the #NMPA. IBI3026 is a fusion protein of a PD-1 antibody and IL-12. Some key facts about IBI 3026:" [X Link](https://x.com/chuminhua432/status/1958899966472065338) [@chuminhua432](/creator/x/chuminhua432) 2025-08-22T14:32Z 2911 followers, 1270 engagements "#Minova Pharma completed a hundred-million RMB level Series B #financing exclusively led by IDG Capital. Minova's homegrown DCA (deoxycholic acid) injection wasapproved for market in China in June becoming China's first aproved fat-dissolving injection. The company continues to focus on the field of aesthetic-related diseases with new drugs for s androgenetic alopecia and photoaging set to enter clinical development in Q4 2025. In the field of mental health the anti-postpartum depression drug MI078 capsule has completed Phase II clinical studies" [X Link](https://x.com/chuminhua432/status/1959861496076517690) [@chuminhua432](/creator/x/chuminhua432) 2025-08-25T06:12Z 2911 followers, XXX engagements "#MagicRNA announced the completion of nearly RMB100 million in Pre-A+ #financing led by IDG Capital. The funds will be used for the IND filing and IITs of the lead asset #HN2301. Founded in December 2021 MagicRN focuses on nucleic acid drug delivery and therapeutic mRNA innovative drugs. The company has developed a ionizable amino lipid library with the lipid (ILB3132) already commercialized. In 2023 MagicRNA successfully established an engineered cell delivery platform (Engineered Cell Targeted LNP EnC-LNP). The in vivo CAR-T HN2301 developed based on the EnC-LNP platform enter the clinical" [X Link](https://x.com/chuminhua432/status/1961368049984180742) [@chuminhua432](/creator/x/chuminhua432) 2025-08-29T09:59Z 2910 followers, 7424 engagements "#Epigenic Therapeutics a clinical-stage innovative drug development company today announced the completion of a $XX million Series B round of #financing led by Lapam Capital with continued participation from existing investors Qiming Venture Partners and OrbiMed and addition of new investors including IFSC and a renowned investment firm in the industry. This round of funding will primarily support the ongoing clinical development of EPI-003 for chronic hepatitis B functional cure and EPI-001 for hypercholesterolemia treatment. Epigenic focuses on developing next-generation gene modulation" [X Link](https://x.com/chuminhua432/status/1964989928468787325) [@chuminhua432](/creator/x/chuminhua432) 2025-09-08T09:51Z 2911 followers, 1068 engagements "A rumor suggests that $BMY may be poised for a major adjustment in its #China operations. According to the content of a leaked email BMS has signed an agreement to sell its XX% stake in Shanghai Bristol-Myers Squibb Pharmaceutical Co. Ltd. (SASS) along with several related products manufactured and sold exclusively in the mainland China marketincluding Baraclude (entecavir) Bufferin Theragran Monopril (fosinopril) and Velosef (cephradine)to an affiliate of Hillhouse Investment Group (Highland Capital). The transaction is expected to be completed in early 2026 with the specific deal amount yet" [X Link](https://x.com/chuminhua432/status/1966779876482171286) [@chuminhua432](/creator/x/chuminhua432) 2025-09-13T08:23Z 2911 followers, 13.8K engagements "GenFleet Therapeutics has released its global offering prospectus #HKSE with CITIC Securities serving as the sole sponsor. The offering price is set at HKD XXXXX per share with a total of XXXX million shares offered globally resulting in an estimated market capitalization of approximately HKD XXXX billion. The offering is expected to raise approximately HKD XXXXX billion with net proceeds estimated at HKD XXXXX billion. GenFleet is scheduled to officially list on the Hong Kong Stock Exchange on September XX. GenFleet has secured USD XXX million (38.234 million shares) in cornerstone" [X Link](https://x.com/chuminhua432/status/1966789250835489006) [@chuminhua432](/creator/x/chuminhua432) 2025-09-13T09:01Z 2910 followers, 1240 engagements "#Innovent Biologics' dual glucagon/GLP-1 receptor agonist #mazdutide has been approved for a new indication for marketing for glycemic control in adult patients with type X diabetes. Previously the drug has been approved for long-term weight management in adult patients with obesity or overweight. Innovent licensed mazdutide from Eli Lilly" [X Link](https://x.com/chuminhua432/status/1969078645756133517) [@chuminhua432](/creator/x/chuminhua432) 2025-09-19T16:38Z 2911 followers, 1222 engagements "Changchun High-Tech submitted IPO application to HKSE on Sept. XX Changchun High-Tech already listed in Shenzhen stock market. The company is the leading hGH products manufacturer in China" [X Link](https://x.com/chuminhua432/status/1973072930612412655) [@chuminhua432](/creator/x/chuminhua432) 2025-09-30T17:10Z 2911 followers, XXX engagements "On Sept. XX TJ Biopharma announced the completion of nearly RMB XXX million in Series C2 financing. This round was led by a fund under CITIC Capital. The raised funds will primarily support the Ph3clinical trials and marketing applications for tier1 pipelines accelerating the R&D of tier2 pipelines. Tier1 pipeline: X products in marketing application and late-stage clinical phases - Felzartamab: A differentiated domestically produced CD38 antibody its marketing application for multiple myeloma has been accepted -Eftansomatropin Alfa: An innovative fully fused long-acting growth hormone its" [X Link](https://x.com/chuminhua432/status/1973788157801029865) [@chuminhua432](/creator/x/chuminhua432) 2025-10-02T16:32Z 2910 followers, XXX engagements "China Biopharma Tracker - September 2025 #apprvoal #ChinabioTracker Only X new novel drugs received their first marketing approval in September by China's NMPA both are from ex-China 1) Tzield (teplizumab) $SNY CD3 mab for type X diabetes 2) Fexuclue (fexuprazan) P-CAB Yangtze River Pharma licensed from Daewoong Pharma for gastroesophageal reflux disease X drugs approved for new indication including Mazdutide dual glucagon/GLP-1 receptor agonist for T2DM Innovent licensed the drug from $LLY And denosumab biosimiliar from Henlius Fosun' subsidiary appproved in both US and Europe in September" [X Link](https://x.com/chuminhua432/status/1975208988787740936) [@chuminhua432](/creator/x/chuminhua432) 2025-10-06T14:38Z 2910 followers, 3347 engagements "CF PharmaTech officially lists on the Hong Kong Stock Exchange today. Joint sponsors for this IPO are CITIC Securities and CMB International with an issue price of HK$14.75 per share and net proceeds of HK$525.4 million. CF PharmaTech opened at HK$47 per share closing at HK$38.50 up 161.02%" [X Link](https://x.com/chuminhua432/status/1975903458776711361) [@chuminhua432](/creator/x/chuminhua432) 2025-10-08T12:37Z 2910 followers, XXX engagements "$JNJ reported 2025 Q3 earnings XXX% sales increase to $XX billion BCMA CAR-T therapy Carvyktideveloped in partnership with Legend Biotechsaw significant sales growth. Carvykti achieved total sales of $XXX million in Q3 2025 marking an XXXX% yoy increase. Carvykti's sales have already surpassed $X billion this year totaling $XXXXX billion exceeded its full-year total from 2024 which was $XXX million" [X Link](https://x.com/chuminhua432/status/1978396388808593549) [@chuminhua432](/creator/x/chuminhua432) 2025-10-15T09:43Z 2911 followers, 2814 engagements "$GILD s Kite Pharma is doubling down on in vivo CAR-T this time inking a deal worth up to $XXXX billion biobucks with biotech Pregene Biopharma. $XXX million upfront + $XXXX billion milestone Pregene also helped AstraZeneca-owned EsoBiotec design its in vivo CAR-T. The Big Pharma bought out EsoBiotec back in March for up to $X billion dollars" [X Link](https://x.com/chuminhua432/status/1979089000267944072) [@chuminhua432](/creator/x/chuminhua432) 2025-10-17T07:36Z 2911 followers, 2310 engagements "$IMAB announced its intention to pursue a Hong Kong IPO through dual listing on NASDAQ and Hong Kong Stock Exchange (HKEX). The Company intends to operate under the new name of NovaBridge Biosciences. The Company also announced the pending acquisition of VIS-101 a novel bifunctional biologic targeting VEGF-A and ANG2. The pending acquisition will be made by a newly formed subsidiary Visara Inc. (Visara) a NewCo focused on developing ophthalmic therapeutics for serious eye disorders and is expected to be completed later this month. VIS-101 (also named lASKG712) is developed by ASK pharma the" [X Link](https://x.com/chuminhua432/status/1979230110109831631) [@chuminhua432](/creator/x/chuminhua432) 2025-10-17T16:56Z 2911 followers, 2518 engagements "While $IMAB's press release describes VIS-101 "to be acquired by Visara" ASK Pharma's Chinese listing announcement refers to it as a licensing agreement in licensed territories. According to ASK its controlling subsidiary AskGene Pharma has entered into a licensing agreement with Visara. AskGene Pharma grants Visara rights of its ASK G712 (VIS-101) within the licensed territories. The licensed regions include Greater China Singapore Thailand Malaysia Indonesia Vietnam South Korea and India. Visara will pay AskGene a one-time non-refundable upfront payment of $X million within XX business days" [X Link](https://x.com/chuminhua432/status/1979232899074580614) [@chuminhua432](/creator/x/chuminhua432) 2025-10-17T17:07Z 2911 followers, 1868 engagements "#esmo2025 $SMMT Akeso PD-1/VEGF antibody #ivonescimab Ph3 HARMONi-6 trial results Achieve a Clinically Meaningful Benefit over Tislelizumab ( $ONC anti-PD-1 antibody) Combined with Chemotherapy in 1L NSCLC: Median PFS of XXXXX Months vs. XXXX Months HR 0.60" [X Link](https://x.com/chuminhua432/status/1980278974787035625) [@chuminhua432](/creator/x/chuminhua432) 2025-10-20T14:24Z 2911 followers, 1592 engagements "#esmo2025 Merck KGaA and Abbisko Therapeutics Pimicotinib (ABSK021) small-molecule inhibitor of CSF-1R Phase X MANEUVER trial results With median follow-up of XXXX months pimicotinib demonstrated increasing ORR over time from XX% at Week XX to XXXX% Pimicotinib has been granted breakthrough therapy designation (BTD) for the treatment of inoperable TGCT by China National Medical Products Administration (NMPA) and the US Food and Drug Administration (FDA) and priority medicine (PRIME) designation from the European Medicines Agency (EMA). Merck KGaA Darmstadt Germany holds worldwide" [X Link](https://x.com/chuminhua432/status/1980468795484545126) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T02:58Z 2911 followers, 1238 engagements "$SMMT Plans to Submit a BLA in Q4 2025 for Ivonescimab Based on HARMONi Global Phase III Study Results Expansion of Summits Global Phase III Development Program Starts with Initiation of HARMONi-GI3 a New Study in 1L CRC" [X Link](https://x.com/chuminhua432/status/1980538069792235993) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T07:34Z 2911 followers, XXX engagements "Samsung Bioepis and Phrontline Biopharma have entered into a global collaboration agreement on two ADC assets: TJ108 bispecific and dual-payload ADC and another asset to be named. In addition Samsung Bioepis will receive an exclusive license from Phrontline for one TOP1i payload which is applied to Samsung Bioepis ADC pipeline. #licensing Financial terms undisclosed Phrontline is a biotech focus on bispecific dual-payload ADCs" [X Link](https://x.com/chuminhua432/status/1980565331501543635) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T09:22Z 2911 followers, 1275 engagements "#Innovent Biologics has registered a Phase III clinical trial for its novel Claudin18.2-targeting ADC drug #IBI343 for the treatment of pancreatic cancer The trial titled G-HOPE-002 plans to enroll XXX patients with advanced pancreatic cancer. IBI343 features a differentiated design. The ADC technology originates from a collaboration with Synaffix and utilizes glycan-mediated site-specific conjugation with a drug-to-antibody ratio (DAR) of X. It employs a highly internalizing antibody and incorporates Fc silencing mutations. In July Innovent officially disclosed the molecular structure of" [X Link](https://x.com/chuminhua432/status/1945331743558656304) [@chuminhua432](/creator/x/chuminhua432) 2025-07-16T03:56Z 2911 followers, 7939 engagements "Hong Kong Stock Exchange web shows that Vigonvita has passed the hearing and is about to be listed" [X Link](https://x.com/chuminhua432/status/1980617744359084282) [@chuminhua432](/creator/x/chuminhua432) 2025-10-21T12:50Z 2911 followers, XXX engagements "According to the HKEX website Sichuan Biokin Pharma has passed the HKEX hearing and is about to list with Goldman Sachs J.P. Morgan and CITIC Securities serving as joint sponsors" [X Link](https://x.com/chuminhua432/status/1980980146669822362) [@chuminhua432](/creator/x/chuminhua432) 2025-10-22T12:50Z 2911 followers, 1683 engagements
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
@chuminhua432
"$GSK announced that the NMPA has approved Shingrix (GSKs Recombinant Zoster Vaccine or RZV) for the prevention of shingles (herpes zoster) in adults aged XX years and over who are at increased risk of shingles due to immunodeficiency or immunosuppression caused by known disease or therapy. the previous indication for adults aged XX and older"
X Link @chuminhua432 2025-10-15T09:55Z 2911 followers, XXX engagements
"#esmo2025 RemeGen reported the Ph3 RC48-C016 study in Presidential Symposium its HER2 ADC disitamab vedotin (DV) + toripalimab ( Junshi's PD-1 mab) vs chemo as 1L HER2-expressing la/m urothelial carcinoma median PFS: XXXX months vs XXX months reducing the risk of disease progression or death by XX% (HR =0.36 XX% CI: XXXX - XXXX P 0.0001). median OS: XXXX months vs XXXX months XX% reduction in the risk of death (HR = XXXX XX% CI: XXXX - XXXX P 0.0001) ORR assessed by BICR: XXXX% vs 50.2%"
X Link @chuminhua432 2025-10-21T02:31Z 2911 followers, 1873 engagements
"Takeda $TAK has entered into a license and collaboration agreement with Innovent Biologics for two late-stage oncology medicines IBI363 and IBI343 worldwide outside of Greater China. IBI363 PD-1/IL-2-bias bispecific antibody fusion protein is being evaluated in NSCLC and CRC IBI343 a Claudin XXXX ADC is being evaluated in gastric and pancreatic cancers. Takeda will also receive an exclusive option to license global rights outside of Greater China for IBI3001 (EGFRB7H3 ADC) an early-stage investigational medicine. $XXX billion upfront $XXX million equity investment"
X Link @chuminhua432 2025-10-22T02:31Z 2911 followers, 3477 engagements
"$ONC and $ABBV s Pharmacyclics have decided to voluntarily dismiss the patent lawsuit the Big Pharma firm brought against its competitor over their BTK inhibitors. BeOne announced the decision in a securities filing to HKSE. The move comes after the U.S. Patent and Trademark Office (USPTO) recently invalidated all claims of AbbVies patent No. 11672803 which underpinned the Illinois pharmas patent infringement lawsuit filed in 2023"
X Link @chuminhua432 2025-10-03T15:36Z 2911 followers, XXX engagements
"#esmo2025 Kelun-Biotech TROP2 ADC sacituzumab tirumotecan (sac-TMT) which out-licensed to $MRK in 2022 for ex-Greater China rights Phase X OptiTROP-Lung04 trial: in EGFR-mutated NSCLC following progression on EGFR-TKIs receive sac-TMT monotherapy or chemotherapy median PFS of XXX months versus XXX months OS was not reached XX% lower risk of death"
X Link @chuminhua432 2025-10-20T14:54Z 2911 followers, 1538 engagements
"$ZLAB Zai Lab has registered its first Ph3 clinical trial of ZL-1310 (zocilurtatug pelitecan) This randomized open-label clinical trial (n=665) aims to evaluate the efficacy and safety of ZL-1310 (at two dose levels) compared with investigator's choice (Tarlatamab Topotecan Lurbinectedin or Amrubicin) in patients with relapsed SCLC. The primary endpoints are cORR and OS. ZL-1310 is an ADC targeting DLL3 discovered by MediLink Therapeutics using its TAMLIN technology platform. In April 2023 Zai Lab and MediLink Therapeutics entered an agreement acquiring global rights for ZL-1310. In ASCO2025"
X Link @chuminhua432 2025-10-21T12:45Z 2911 followers, 3035 engagements
"Chengdu Hyperway Pharmaceuticals clinical-stage startup specializing in brain-penetrant small molecule drug discovery and development announced the completion of its Series B financing exceeding RMB XXX million. This round was led by Huagai Capital. Hyperway was founded in 2019 with a focus on multiple therapeutic areas including oncology pain management and central nervous system disorders. X candidates in Phase 2: HBW-004285 (a non-addictive Nav1.8 inhibitor surpassing VX-548 in pharmacokinetics safety and onset speed) and HBW-3220 (a 4th generation BTK inhibitor overcoming drug"
X Link @chuminhua432 2025-10-22T12:20Z 2911 followers, 1048 engagements
"BeiGene $ONC Announces First Quarter 2025 Financial Results and Business Updates Q1 2025 total revenues increased XX% to$1.1 billionwith BRUKINSA(zanubrutinib) global sales increasing XX% to$792 millionon strong demand growth vs. Q1 2024 Advanced late-stage hematology and solid tumor pipelines with plan to host Investor R&D Day onJune XX Secured shareholder approval to rename the Company toBeOne Medicines Ltd.and redomicile toSwitzerland"
X Link @chuminhua432 2025-05-07T14:32Z 2910 followers, XXX engagements
"BeOne Medicines (BeiGene) $ONC has recently registered a Ph2 study (CTR20252981) on #CDE for its independently developed #IRAK4 PROTAC degrader BGB-45035 vs placebo in patients with moderate to severe active rheumatoid arthritis who have had an inadequate response to csDMARDs or bDMARDs/tsDMARDs. This is currently the only IRAK4 degrader drug in Phase II clinical trials globally. The primary clinical endpoint is the disease activity score based on C-reactive protein at Week XX. Other IRAK4 degrader in clinical trials: LT-002-158 Shanghai Leadingtac Pharma Ph1"
X Link @chuminhua432 2025-07-30T07:12Z 2910 followers, 1308 engagements
"#Akeso said in its H1 2025 report its lung cancer drug ivonescimab (PD-1/EGFR) for the first time clearly extended overall survival (OS) in a pivotal study. The final analysis of the Phase III HARMONi-A trial met its OS goal showing that ivonescimab delivered "a statistically significant and clinically meaningful OS benefit.""
X Link @chuminhua432 2025-08-27T02:31Z 2910 followers, 9751 engagements
"Kailera Therapeutics Announces $XXX Million Series B Financing Kailera Therapeutics details of which first emerged in May 2024 under the name Hercules CM NewCo emerged from stealth Tuesday with plans to develop a portfolio of GLP-1 drugs. The drugs were acquired from Jiangsu Hengrui Pharmaceuticals"
X Link @chuminhua432 2025-10-15T09:28Z 2910 followers, 1042 engagements
"1/ #Hansoh Pharmaceutical has registered a Phase 1b clinical trial for B7H3 ADC HS-20093 in combination with other treatments for osteosarcoma on"
X Link @chuminhua432 2024-11-23T12:23Z 2911 followers, XXX engagements
"#Innovent $IVBXF has registered a Ph2 clinical study to evaluate weekly subcutaneous injections of IBI362 (GLP-1R/GCGR dual-target agonist) in Chinese patients with heart failure with HFpEF or HFmrEF and obesity. NCT0686290"
X Link @chuminhua432 2025-03-07T07:43Z 2911 followers, 3777 engagements
"#3SBio published the Ph2 results of SSGJ-707 #SSGJ707 a bispecific antibody targeting PD-1 and VEGF as a monotherapy in patients with advanced NSCLC . Among the XX pts completed at least one efficacy evaluation ORR and DCR were XXXX% (8/27)/85.2% (23/27) 61.8%(21/34)97.1% (33/34) XXXX% (6/11)/90.9% (10/11) and XX% (1/4)/75% (3/4) at doses of 5mg/kg Q3W 10mg/kg Q3W 20mg/kg Q3W and XX mg/kg Q3W respectively. Select subgroups are summarized in SSGJ-707 10mg/kg Q3W. The ORR were XXXX% (12/22) and 75%(9/12) in non-squamous and squamous pts respectively"
X Link @chuminhua432 2025-05-23T08:08Z 2911 followers, 12K engagements
"On June XX #Innovent Biologics held its annual R&D Day event. Over its XX years since establishment Innovent has launched XX new drugs. In 2024 the company recorded revenue of RMB XXX billion. Focusing on oncology as its core therapeutic area Innovent is advancing its pipeline through next-generation IO therapies and next-generation ADCs. The core pipeline includes PD-1/IL-2 bispecific antibody #IBI363 while next-generation ADCs encompass dual-target ADCs and dual-toxin ADCs"
X Link @chuminhua432 2025-06-30T06:20Z 2911 followers, 3081 engagements
"Legend Biotech $LEGN registered a Phase I clinical trial for LUCAR-G19 to treat autoimmune diseases. NCT07049081 The study plans to enroll XX patients with relapsed or refractory autoimmune diseases including systemic lupus erythematosus systemic sclerosis ANCA-associated vasculitis inflammatory myopathy Takayasu arteritis IgG4-related disease. The study has X sites in #China. LUCAR is a non-gene-editing allogeneic CAR-T technology platform independently developed by Legend Biotech. It employs endogenous TCR silencing technology blocking complex formation by expressing proteins that"
X Link @chuminhua432 2025-07-04T09:07Z 2911 followers, 2837 engagements
"$PFE announced the completion of a global ex-China licensing agreement with 3SBio granting Pfizer exclusive rights for the development manufacturing and commercialization of 3SBios SSGJ-707 Additionally the agreement provides Pfizer the option to extend the license to include exclusive development and commercialization rights to SSGJ-707 in China. In exchange for the exclusive rights in China Pfizer will pay 3SBio up to $XXX million in option payments"
X Link @chuminhua432 2025-07-25T14:29Z 2911 followers, XXX engagements
"#NMPA CDE website #Innovent Biologics' PD-1/IL-2-bias bispecific antibody therapy #IBI363 has received clearance for two clinical trial applications. X as neoadjuvant therapy for non-squamous non-small cell lung cancer X IBI363 + bevacizumab for advanced solid tumor (EGFR+ advanced NSCLC platinum-resistant ovarian cancer). ASCO2025 IBI363 was featured in three oral presentations covering colorectal cancer melanoma and NSCLC. Previously Innovents PD-1 monoclonal antibody sintilimab + bevacizumab had already been approved in China for the treatment of locally advanced or metastatic non-squamous"
X Link @chuminhua432 2025-07-29T10:03Z 2911 followers, XXX engagements
"#Vigonvita submitted its Hong Kong IPO prospectus on January XX 2025 which expired after six months on July XX and was resubmitted on July 31"
X Link @chuminhua432 2025-08-01T10:16Z 2911 followers, XXX engagements
"#Innovent Biologics' U.S. subsidiary Fortvita Biologics has registered a Phase X clinical trial for the small-molecule GLP-1 receptor agonist #IBI3032 The Phase X trial plans to enroll XX healthy participants divided into X cohorts with each cohort consisting of X participants receiving IBI3032 or placebo in a 6:2. According to information disclosed by Innovent at this year's JPM IBI3032 is an oral small-molecule GLP-1 receptor agonist"
X Link @chuminhua432 2025-08-14T13:10Z 2911 followers, 2038 engagements
"#Innovent Biologics' clinical trial application for #IBI3026 has been accepted by the #NMPA. IBI3026 is a fusion protein of a PD-1 antibody and IL-12. Some key facts about IBI 3026:"
X Link @chuminhua432 2025-08-22T14:32Z 2911 followers, 1270 engagements
"#Minova Pharma completed a hundred-million RMB level Series B #financing exclusively led by IDG Capital. Minova's homegrown DCA (deoxycholic acid) injection wasapproved for market in China in June becoming China's first aproved fat-dissolving injection. The company continues to focus on the field of aesthetic-related diseases with new drugs for s androgenetic alopecia and photoaging set to enter clinical development in Q4 2025. In the field of mental health the anti-postpartum depression drug MI078 capsule has completed Phase II clinical studies"
X Link @chuminhua432 2025-08-25T06:12Z 2911 followers, XXX engagements
"#MagicRNA announced the completion of nearly RMB100 million in Pre-A+ #financing led by IDG Capital. The funds will be used for the IND filing and IITs of the lead asset #HN2301. Founded in December 2021 MagicRN focuses on nucleic acid drug delivery and therapeutic mRNA innovative drugs. The company has developed a ionizable amino lipid library with the lipid (ILB3132) already commercialized. In 2023 MagicRNA successfully established an engineered cell delivery platform (Engineered Cell Targeted LNP EnC-LNP). The in vivo CAR-T HN2301 developed based on the EnC-LNP platform enter the clinical"
X Link @chuminhua432 2025-08-29T09:59Z 2910 followers, 7424 engagements
"#Epigenic Therapeutics a clinical-stage innovative drug development company today announced the completion of a $XX million Series B round of #financing led by Lapam Capital with continued participation from existing investors Qiming Venture Partners and OrbiMed and addition of new investors including IFSC and a renowned investment firm in the industry. This round of funding will primarily support the ongoing clinical development of EPI-003 for chronic hepatitis B functional cure and EPI-001 for hypercholesterolemia treatment. Epigenic focuses on developing next-generation gene modulation"
X Link @chuminhua432 2025-09-08T09:51Z 2911 followers, 1068 engagements
"A rumor suggests that $BMY may be poised for a major adjustment in its #China operations. According to the content of a leaked email BMS has signed an agreement to sell its XX% stake in Shanghai Bristol-Myers Squibb Pharmaceutical Co. Ltd. (SASS) along with several related products manufactured and sold exclusively in the mainland China marketincluding Baraclude (entecavir) Bufferin Theragran Monopril (fosinopril) and Velosef (cephradine)to an affiliate of Hillhouse Investment Group (Highland Capital). The transaction is expected to be completed in early 2026 with the specific deal amount yet"
X Link @chuminhua432 2025-09-13T08:23Z 2911 followers, 13.8K engagements
"GenFleet Therapeutics has released its global offering prospectus #HKSE with CITIC Securities serving as the sole sponsor. The offering price is set at HKD XXXXX per share with a total of XXXX million shares offered globally resulting in an estimated market capitalization of approximately HKD XXXX billion. The offering is expected to raise approximately HKD XXXXX billion with net proceeds estimated at HKD XXXXX billion. GenFleet is scheduled to officially list on the Hong Kong Stock Exchange on September XX. GenFleet has secured USD XXX million (38.234 million shares) in cornerstone"
X Link @chuminhua432 2025-09-13T09:01Z 2910 followers, 1240 engagements
"#Innovent Biologics' dual glucagon/GLP-1 receptor agonist #mazdutide has been approved for a new indication for marketing for glycemic control in adult patients with type X diabetes. Previously the drug has been approved for long-term weight management in adult patients with obesity or overweight. Innovent licensed mazdutide from Eli Lilly"
X Link @chuminhua432 2025-09-19T16:38Z 2911 followers, 1222 engagements
"Changchun High-Tech submitted IPO application to HKSE on Sept. XX Changchun High-Tech already listed in Shenzhen stock market. The company is the leading hGH products manufacturer in China"
X Link @chuminhua432 2025-09-30T17:10Z 2911 followers, XXX engagements
"On Sept. XX TJ Biopharma announced the completion of nearly RMB XXX million in Series C2 financing. This round was led by a fund under CITIC Capital. The raised funds will primarily support the Ph3clinical trials and marketing applications for tier1 pipelines accelerating the R&D of tier2 pipelines. Tier1 pipeline: X products in marketing application and late-stage clinical phases - Felzartamab: A differentiated domestically produced CD38 antibody its marketing application for multiple myeloma has been accepted -Eftansomatropin Alfa: An innovative fully fused long-acting growth hormone its"
X Link @chuminhua432 2025-10-02T16:32Z 2910 followers, XXX engagements
"China Biopharma Tracker - September 2025 #apprvoal #ChinabioTracker Only X new novel drugs received their first marketing approval in September by China's NMPA both are from ex-China 1) Tzield (teplizumab) $SNY CD3 mab for type X diabetes 2) Fexuclue (fexuprazan) P-CAB Yangtze River Pharma licensed from Daewoong Pharma for gastroesophageal reflux disease X drugs approved for new indication including Mazdutide dual glucagon/GLP-1 receptor agonist for T2DM Innovent licensed the drug from $LLY And denosumab biosimiliar from Henlius Fosun' subsidiary appproved in both US and Europe in September"
X Link @chuminhua432 2025-10-06T14:38Z 2910 followers, 3347 engagements
"CF PharmaTech officially lists on the Hong Kong Stock Exchange today. Joint sponsors for this IPO are CITIC Securities and CMB International with an issue price of HK$14.75 per share and net proceeds of HK$525.4 million. CF PharmaTech opened at HK$47 per share closing at HK$38.50 up 161.02%"
X Link @chuminhua432 2025-10-08T12:37Z 2910 followers, XXX engagements
"$JNJ reported 2025 Q3 earnings XXX% sales increase to $XX billion BCMA CAR-T therapy Carvyktideveloped in partnership with Legend Biotechsaw significant sales growth. Carvykti achieved total sales of $XXX million in Q3 2025 marking an XXXX% yoy increase. Carvykti's sales have already surpassed $X billion this year totaling $XXXXX billion exceeded its full-year total from 2024 which was $XXX million"
X Link @chuminhua432 2025-10-15T09:43Z 2911 followers, 2814 engagements
"$GILD s Kite Pharma is doubling down on in vivo CAR-T this time inking a deal worth up to $XXXX billion biobucks with biotech Pregene Biopharma. $XXX million upfront + $XXXX billion milestone Pregene also helped AstraZeneca-owned EsoBiotec design its in vivo CAR-T. The Big Pharma bought out EsoBiotec back in March for up to $X billion dollars"
X Link @chuminhua432 2025-10-17T07:36Z 2911 followers, 2310 engagements
"$IMAB announced its intention to pursue a Hong Kong IPO through dual listing on NASDAQ and Hong Kong Stock Exchange (HKEX). The Company intends to operate under the new name of NovaBridge Biosciences. The Company also announced the pending acquisition of VIS-101 a novel bifunctional biologic targeting VEGF-A and ANG2. The pending acquisition will be made by a newly formed subsidiary Visara Inc. (Visara) a NewCo focused on developing ophthalmic therapeutics for serious eye disorders and is expected to be completed later this month. VIS-101 (also named lASKG712) is developed by ASK pharma the"
X Link @chuminhua432 2025-10-17T16:56Z 2911 followers, 2518 engagements
"While $IMAB's press release describes VIS-101 "to be acquired by Visara" ASK Pharma's Chinese listing announcement refers to it as a licensing agreement in licensed territories. According to ASK its controlling subsidiary AskGene Pharma has entered into a licensing agreement with Visara. AskGene Pharma grants Visara rights of its ASK G712 (VIS-101) within the licensed territories. The licensed regions include Greater China Singapore Thailand Malaysia Indonesia Vietnam South Korea and India. Visara will pay AskGene a one-time non-refundable upfront payment of $X million within XX business days"
X Link @chuminhua432 2025-10-17T17:07Z 2911 followers, 1868 engagements
"#esmo2025 $SMMT Akeso PD-1/VEGF antibody #ivonescimab Ph3 HARMONi-6 trial results Achieve a Clinically Meaningful Benefit over Tislelizumab ( $ONC anti-PD-1 antibody) Combined with Chemotherapy in 1L NSCLC: Median PFS of XXXXX Months vs. XXXX Months HR 0.60"
X Link @chuminhua432 2025-10-20T14:24Z 2911 followers, 1592 engagements
"#esmo2025 Merck KGaA and Abbisko Therapeutics Pimicotinib (ABSK021) small-molecule inhibitor of CSF-1R Phase X MANEUVER trial results With median follow-up of XXXX months pimicotinib demonstrated increasing ORR over time from XX% at Week XX to XXXX% Pimicotinib has been granted breakthrough therapy designation (BTD) for the treatment of inoperable TGCT by China National Medical Products Administration (NMPA) and the US Food and Drug Administration (FDA) and priority medicine (PRIME) designation from the European Medicines Agency (EMA). Merck KGaA Darmstadt Germany holds worldwide"
X Link @chuminhua432 2025-10-21T02:58Z 2911 followers, 1238 engagements
"$SMMT Plans to Submit a BLA in Q4 2025 for Ivonescimab Based on HARMONi Global Phase III Study Results Expansion of Summits Global Phase III Development Program Starts with Initiation of HARMONi-GI3 a New Study in 1L CRC"
X Link @chuminhua432 2025-10-21T07:34Z 2911 followers, XXX engagements
"Samsung Bioepis and Phrontline Biopharma have entered into a global collaboration agreement on two ADC assets: TJ108 bispecific and dual-payload ADC and another asset to be named. In addition Samsung Bioepis will receive an exclusive license from Phrontline for one TOP1i payload which is applied to Samsung Bioepis ADC pipeline. #licensing Financial terms undisclosed Phrontline is a biotech focus on bispecific dual-payload ADCs"
X Link @chuminhua432 2025-10-21T09:22Z 2911 followers, 1275 engagements
"#Innovent Biologics has registered a Phase III clinical trial for its novel Claudin18.2-targeting ADC drug #IBI343 for the treatment of pancreatic cancer The trial titled G-HOPE-002 plans to enroll XXX patients with advanced pancreatic cancer. IBI343 features a differentiated design. The ADC technology originates from a collaboration with Synaffix and utilizes glycan-mediated site-specific conjugation with a drug-to-antibody ratio (DAR) of X. It employs a highly internalizing antibody and incorporates Fc silencing mutations. In July Innovent officially disclosed the molecular structure of"
X Link @chuminhua432 2025-07-16T03:56Z 2911 followers, 7939 engagements
"Hong Kong Stock Exchange web shows that Vigonvita has passed the hearing and is about to be listed"
X Link @chuminhua432 2025-10-21T12:50Z 2911 followers, XXX engagements
"According to the HKEX website Sichuan Biokin Pharma has passed the HKEX hearing and is about to list with Goldman Sachs J.P. Morgan and CITIC Securities serving as joint sponsors"
X Link @chuminhua432 2025-10-22T12:50Z 2911 followers, 1683 engagements
/creator/twitter::3643934180/posts