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[@NoseRubInvest](/creator/twitter/NoseRubInvest)
"$QURE Can I say something w/o ppl getting mad Isn't it totally crazy placebo beats AMT-130 at the main endpoints they're pointing to to show efficacy Pbo beats both drug arms at 12mo with cUHDRS TFC and NfL. Forget XX% slowing of dz; pbo has XXX% slowing of dz progression"  
[X Link](https://x.com/NoseRubInvest/status/1976333611273159046) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-09T17:07Z 1866 followers, 25.2K engagements


"@lifeisblank21 more $BMEA context of the denominator "A total of XXX patients received at least one dose of icovamenib and were considered evaluable for the modified intent-to-treat (mITT) population.""  
[X Link](https://x.com/NoseRubInvest/status/1975294523736793368) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-06T20:18Z 1864 followers, 10.7K engagements


"Pbo were eligible for crossover at 12mo and we don't know what happened to those that didn't crossover. It seems kinda funny to approve on just natural history when pbo isn't even matching natural history"  
[X Link](https://x.com/NoseRubInvest/status/1976333693305356697) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-09T17:07Z 1864 followers, 3208 engagements


"I think the lesson is to study the insane jedi mind tricks that made FDA allow external control here and the media to celebrate these "results" like crazy $QURE"  
[X Link](https://x.com/NoseRubInvest/status/1976333851799715991) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-09T17:08Z 1864 followers, 4479 engagements


"@A_May_MD @idalopirdine @plainyogurt21 @anthonystaj I agree with both of you guys's takes. I don't know if FDA realized they opened Pandora's box by saying external control cUHDRS *may* be acceptable and QURE just ran with it and spent all their time controlling the media and KOLS but here we are. 🤷♂"  
[X Link](https://x.com/NoseRubInvest/status/1980009480101462117) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-19T20:33Z 1866 followers, 1371 engagements


"@jq1234t It feels like a basic DD q is does the efficacy hold up when excluding those EE sites And I dont think you could figure out the con from just the Ph2 results article"  
[X Link](https://x.com/NoseRubInvest/status/1980041328542257495) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-19T22:40Z 1866 followers, XXX engagements


"@jq1234t I am a bit sympathetic to Novo since it feels KBP knew the reasons Otsuka walked from ocedurenone and was prepped to play hide the ball with Novo"  
[X Link](https://x.com/NoseRubInvest/status/1980041412831010926) [@NoseRubInvest](/creator/x/NoseRubInvest) 2025-10-19T22:40Z 1866 followers, XXX engagements