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[@BiotechSho99376](/creator/twitter/BiotechSho99376)
"My $MLTX short thesis wasn't clever but hinged on 1) HS studies produce idiosyncratic placebo response e.g $SLRN Izokibep 'bump' at wk XX vs wk16 $IFRX prior C5a 'high' placebo rates at P2b. 2) HiSCR endpoint variability. 3) Bim data v. high bar to clear 4) Management pumping"  
[X Link](https://x.com/BiotechSho99376/status/1972607076653531196) [@BiotechSho99376](/creator/x/BiotechSho99376) 2025-09-29T10:19Z XXX followers, 1002 engagements


"$IOBT to run another study - ridiculous outcome @VPrasadMDMPH. You're happy to accept leucovorin but $IOBT shouldn't even bother filing even before you have seen mature OS data Either this is the most X faced FDA ever or $IOBT cooked something up"  
[X Link](https://x.com/BiotechSho99376/status/1972624690587017383) [@BiotechSho99376](/creator/x/BiotechSho99376) 2025-09-29T11:29Z XXX followers, 3007 engagements


"@avidresearch Was it powered for efficacy over Oma"  
[X Link](https://x.com/BiotechSho99376/status/1980250855157690578) [@BiotechSho99376](/creator/x/BiotechSho99376) 2025-10-20T12:32Z XXX followers, XXX engagements


"$CRSP anyone have a logical thesis (not "bUt ITs CrISpR") that can justify it here at $6.6B cap"  
[X Link](https://x.com/BiotechSho99376/status/1975934480134164521) [@BiotechSho99376](/creator/x/BiotechSho99376) 2025-10-08T14:41Z XXX followers, 2808 engagements