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[@biotechsanya2](/creator/twitter/biotechsanya2)
"$IFRX-- I *think* the main question is: did Avacopan fail because of insufficient blockade on of C5aR OR because C5aR s not rate-limiting If INF904 is a *better* Avacopan it DOESN'T matter if the reason why Ava' failed is that C5aR blockade doesn't achieve anything due to TNF-a signalling; other "Ils" is what drives signalling-- if the case is that C5aR blockade (IFRX thinks they have a more potent Ava') IS sufficient this COULD be a win. I think the odds of this working are minimal as we know that X C5a inhibitors have already failed that being said there's a small chance this hits as this"  
[X Link](https://x.com/biotechsanya2/status/1978587133511184878) [@biotechsanya2](/creator/x/biotechsanya2) 2025-10-15T22:21Z XXX followers, XXX engagements


"@StreetCred2017 Yes I am referring to Avas failed HS trial. Also interesting they have never tested this in CSU despite sort of similar ideation therein and pathways etc"  
[X Link](https://x.com/biotechsanya2/status/1978589768918200775) [@biotechsanya2](/creator/x/biotechsanya2) 2025-10-15T22:32Z XXX followers, XXX engagements


"@seedy19tron @KiefChief69 @CrocsAnalyst seedy is nktr a buyout candidate can you remind me pls also do they have a differentiated MoA Not sure about these parts. thx"  
[X Link](https://x.com/biotechsanya2/status/1980099579761524768) [@biotechsanya2](/creator/x/biotechsanya2) 2025-10-20T02:31Z XXX followers, XXX engagements