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[@ByMadeleineA](/creator/twitter/ByMadeleineA)
"Adverse events in Stellar-303. Is this really safer than Cabo $EXEL #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1980168229755801658) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-20T07:04Z 8094 followers, 2828 engagements


"Cross-trial comparison of Datroway vs Trodelvy in first-line TNBC at #ESMO25. $AZN & $DSNKY have the edge over $GILD (OS data immature with Trodelvy)"  
[X Link](https://x.com/ByMadeleineA/status/1979802489672319468) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T06:51Z 8094 followers, 5641 engagements


"The #ESMO25 discussant Dr Ana Garrido-Castro weighs in on how to choose between Trodelvy & Datroway"  
[X Link](https://x.com/ByMadeleineA/status/1979819710893138065) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T07:59Z 8094 followers, 1180 engagements


"Missed this at the time of the presentation as footnote is so small: X gr3 pneumonitis then death in Tropion-Breast02 was deemed related to disease $AZN $DSNKY #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1979846122308026423) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T09:44Z 8094 followers, 4033 engagements


"Responses across cancer types and in PDAC with $INCY's KRAS G12D inhibitor at #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1979899579051938126) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T13:16Z 8094 followers, 2415 engagements


"Padcev plus Keytruda sets the perioperative bladder cancer bar at #ESMO25 $PFE $ALPMF $MRK"  
[X Link](https://x.com/ByMadeleineA/status/1979599881590153668) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-18T17:26Z 8094 followers, 1810 engagements


"Response rates with Ralu-dxd at #ESMO25 XX% ORR across doses $MRK $DSNKY"  
[X Link](https://x.com/ByMadeleineA/status/1979909635105546372) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T13:56Z 8094 followers, 20.1K engagements


"$JNJ sees early promise with Rybrevant in relapsed head & neck cancer and is planning a phase X first-line trial. I spoke to the company ahead of #ESMO25 for @ApexOnco"  
[X Link](https://x.com/ByMadeleineA/status/1979918916836012310) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T14:33Z 8094 followers, 17.9K engagements


"More info on Stellar-303 deaths #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1980177020958204101) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-20T07:39Z 8094 followers, 1053 engagements


"German Merck's #ESMO25 booth. Well that's one way to wake yourself up on a tired Monday morning"  
[X Link](https://x.com/ByMadeleineA/status/1980171041654874169) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-20T07:15Z 8094 followers, 2346 engagements


"@Sanctuary_Bio For a moment I thought you were talking about the Merck stand"  
[X Link](https://x.com/ByMadeleineA/status/1980181781568442432) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-20T07:58Z 8094 followers, XXX engagements


"Carvykti is nearly a blockbuster: $963m in sales in FY 2024 ($334m in Q4 ) $JNJ $LEGN"  
[X Link](https://x.com/ByMadeleineA/status/1882039390433923332) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-01-22T12:15Z 8086 followers, 10.6K engagements


"$PFE jumps straight from phase X to phase X with its EZH2 inhibitor mevrometostat. What could possibly go wrong Via @ApexOnco $IPN.PA $DSNKY $NVS"  
[X Link](https://x.com/ByMadeleineA/status/1825509871296364953) [@ByMadeleineA](/creator/x/ByMadeleineA) 2024-08-19T12:27Z 8093 followers, 5572 engagements


"We were right about Tropion-Breast02 $AZN #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1977658659653226681) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-13T08:52Z 8094 followers, 5270 engagements


"$RHHY is out with oral SERD data ahead of its #ESMO25 presentation. The ITT result looks clearly driven by ESR1m pts; the question now is whether Roche has done enough to get a broad label $LLY $ARVN $PFE"  
[X Link](https://x.com/ByMadeleineA/status/1979417010497872017) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-18T05:19Z 8095 followers, 4793 engagements


"Well these are the most promising signs I think we've seen in non-ESR1m pts with a SERD. And $RHHBY has been clever by enrolling XX% of pts in Evera with ESR1m. Now over to the FDA #ESMO25 $LLY $PFE $ARVN"  
[X Link](https://x.com/ByMadeleineA/status/1979466325064880363) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-18T08:35Z 8094 followers, 1819 engagements


"Enhertus perioperative Destiny beckons but watch out for ILD. The @ApexOnco take on Destiny-Breast05 & Destiny-Breast11 data at #ESMO25 $AZN $DSKNY"  
[X Link](https://x.com/ByMadeleineA/status/1979604977753460771) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-18T17:46Z 8093 followers, 3034 engagements


"#ESMO24 presentation on $ALPMY's KRAS G12D degrader zooms in on PDAC & NSCLC pts. Favourable vs the overall X% ORR across the trial in the abstract but small pt numbers involved"  
[X Link](https://x.com/ByMadeleineA/status/1835304095441211644) [@ByMadeleineA](/creator/x/ByMadeleineA) 2024-09-15T13:06Z 8094 followers, 13.4K engagements


"$RVMD shows selective KRAS G12D promise at #Enasymp24. My take via @ApexOnco $ALPMY"  
[X Link](https://x.com/ByMadeleineA/status/1850891989446721772) [@ByMadeleineA](/creator/x/ByMadeleineA) 2024-10-28T13:26Z 8092 followers, 4352 engagements


"$EXEL stops Stellar-305 trial of zanzalintinib. My most recent take on this asset via @ApexOnco"  
[X Link](https://x.com/ByMadeleineA/status/1950104406193484178) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-07-29T08:01Z 8094 followers, 2042 engagements


"PFS curves with Trodelvy in Ascent-03 $GILD #ESMO25"  
[X Link](https://x.com/ByMadeleineA/status/1979810648436687097) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-19T07:23Z 8094 followers, XXX engagements


"Compare the wording on OS from $AZN & $DSKNY on Tropion-Breast02 vs $GILD on Ascent-03. Datroway "stat sig & clinically meaningful" on both PFS & OS but only "no OS detriment" for Trodelvy"  
[X Link](https://x.com/ByMadeleineA/status/1975114941582717427) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-06T08:24Z 8094 followers, 9388 engagements


"More info needed on $EXEL's Cabometyx follow-on zanzalintinib in colorectal cancer the #ESMO25 discussant says"  
[X Link](https://x.com/ByMadeleineA/status/1980211479485022714) [@ByMadeleineA](/creator/x/ByMadeleineA) 2025-10-20T09:56Z 8094 followers, 1320 engagements