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[@boredbuyside](/creator/twitter/boredbuyside)
"More on Luti: data in both TNF experience & naive pts. TNF trial: HiSCR50 49-60% & Naive trial: 66%. In TNF trial they had XX% in Hurley Stage X (more severe) but in naive population I would assume small Stage X population"  
[X Link](https://x.com/boredbuyside/status/1978830438815637528) [@boredbuyside](/creator/x/boredbuyside) 2025-10-16T14:28Z XXX followers, XXX engagements


"Nice win for $IRON bitopertin getting a CNPV"  
[X Link](https://x.com/boredbuyside/status/1978931937361158535) [@boredbuyside](/creator/x/boredbuyside) 2025-10-16T21:11Z XXX followers, 2734 engagements


"$IRON update on '0974 in NDD-CKD where benefit was mostly seen in pts w/ higher baseline EPO makes complete sense in IRE context of the disease. Not sure it is enough to take the drug forward there but they weren't getting credit there anyway"  
[X Link](https://x.com/boredbuyside/status/1980275790857032076) [@boredbuyside](/creator/x/boredbuyside) 2025-10-20T14:11Z XXX followers, XXX engagements


"@TheBiotechBear The activation of the NLRP3 inflammasome leads to the activation of caspase-1 (also known as IL-1-converting enzyme or ICE). As a result anything that helps neutralize NLRP3 will impact the IL-1 pathway as well"  
[X Link](https://x.com/boredbuyside/status/1981447340419355060) [@boredbuyside](/creator/x/boredbuyside) 2025-10-23T19:47Z XXX followers, XXX engagements