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[@OncBrothers](/creator/twitter/OncBrothers)
"2 wks to #ESMO25 Heres a📝of🔑studies for GeneralOnc that could change/reinforce SoC: - #DESTINYBreast 05&11 - #monarchE & #NATALEE - #VIKTORIA1 - #FORTITUDE01 - #DYNAMIC3 - #STELLAR303 - #KN905 - #IMVigor011 - #PSMAddition - #MDTBridge #OncTwitter @myESMO @OncoAlert"  
[X Link](https://x.com/OncBrothers/status/1974460748945608742) [@OncBrothers](/creator/x/OncBrothers) 2025-10-04T13:05Z 19.3K followers, 26.2K engagements


"6. HER2+ NSCLC: #SOHO01 & #BeamionLung01. 2TKIs: - Sevabertinib ORR XX% (in pretreated) and XX% in Rx naive. Pending @US_FDA approval. - Zongertinib ORR XX% and DCR: XX% (in Rx naive). Approved in Aug 2025 after systemic chemo. 8/12"  
[X Link](https://x.com/OncBrothers/status/1979229799471042906) [@OncBrothers](/creator/x/OncBrothers) 2025-10-17T16:55Z 19.3K followers, 1518 engagements


"8. #ALBAN: PhIII BCG + Atezolizumab vs. BCG alone in BCG naive HR-NMIBC - Negative study - No significant improvement in EFS - But POTOMAC 👇👇 is positive 10/12"  
[X Link](https://x.com/OncBrothers/status/1979229812649583060) [@OncBrothers](/creator/x/OncBrothers) 2025-10-17T16:55Z 19.3K followers, 1153 engagements


"4. #VIKTROIA1: PhIII Gedatolisib (IV PI3K/mTORi) + Fulv +/- Palbo vs. Fulv in HR+ after CdK4/6i - mPFS 9.3mos vs. 2.0mos triplet vs. Fulvestrant in WT (Fulv alone is not what we do today in our practice) - Main AEs were Gr1/2. Hyperglycemia XXX% and diarrhea 16.9%. 6/13"  
[X Link](https://x.com/OncBrothers/status/1979594613154312439) [@OncBrothers](/creator/x/OncBrothers) 2025-10-18T17:05Z 19.3K followers, 1829 engagements


"5. #KEYNOTE905: PeriOP EV + Pembro in cis-ineligible MIBC followed by postOP EV + Pembro: - EFS At 2yrs: XXXX% vs. XXXX% - EFS HR: XXXX - OS at 2yrs: XXXX% vs. XXXX (HR: 0.50) - We will now have KN905 and NIAGARA as our options for MIBC 7/13"  
[X Link](https://x.com/OncBrothers/status/1979594620263633355) [@OncBrothers](/creator/x/OncBrothers) 2025-10-18T17:05Z 19.3K followers, XXX engagements


"5. #IMvigor011: PhIII adj atezolizumab in high-risk MIBC who are ctDNA+ - mDFS XXX vs. XXX mos (HR: 0.64) - mOS XXXX vs. XXXX mos (HR: 0.59) - If using adj Rx thisll be the new SoC. Can we extrapolate this to KN905 and NIAGARA @apolo_andrea @PGrivasMDPhD 7/10"  
[X Link](https://x.com/OncBrothers/status/1980325524250779791) [@OncBrothers](/creator/x/OncBrothers) 2025-10-20T17:29Z 19.3K followers, 4346 engagements


"7. #MATTERHORN: Ph III Durvalumab + FLOT✂Durva vs NeoAdj FLOT in resectable GEJ/Gastric Ca. - Improved OS in all comers (HR: 0.78) - mOS at 3yrs: XXXX% vs. XXXX% - This is now the SoC since its initial presentation at @ASCO - What about PDL1 negative 🤔🤔 9/12"  
[X Link](https://x.com/OncBrothers/status/1979229805687042290) [@OncBrothers](/creator/x/OncBrothers) 2025-10-17T16:55Z 19.3K followers, 2008 engagements


"Wishing everyone celebrating a very Happy Diwali 🙏🏽🙏🏽"  
[X Link](https://x.com/OncBrothers/status/1980256748138016962) [@OncBrothers](/creator/x/OncBrothers) 2025-10-20T12:56Z 19.3K followers, 3049 engagements


"@AnisToumeh @dr_yakupergun @UGrewalMD @GIMedOnc @GIcancerDoc @rutikamehtaMD @KlempnerSam @YJanjigianMD And if negative youd forego Durva after using it upfront"  
[X Link](https://x.com/OncBrothers/status/1981100323520307206) [@OncBrothers](/creator/x/OncBrothers) 2025-10-22T20:48Z 19.3K followers, XXX engagements


"Day X #ESMO25 Highlights: Breast Ca: X. #POSITIVE 🤰 outcomes X. #monarchE HR+ Adj Abema X. #NATALEE HR+ Adj Ribo Lung Ca: X. #NorthStar Local Rx in mEGFR X. #FLAURA2 Chemo + Osi in mEGFR X. #SOHO01 & #BeamionLung01 HER2+ NSCLC 1/12 #OncTwitter @myESMO @OncUpdates"  
[X Link](https://x.com/OncBrothers/status/1979229758278795690) [@OncBrothers](/creator/x/OncBrothers) 2025-10-17T16:55Z 19.3K followers, 21.4K engagements


"GI Malignancy: X. #MATTERHORN FLOT-Durva in resectable Gastric/GEJ GU: X. #ALBAN: Atezo + BCG in HR-NMIBC X. #POTOMAC: Durva + BCG in HR-NMIBC Supp/Pall Onc: XX. #REaCTHold: De-escalating 🦴 modifying agents 2/12"  
[X Link](https://x.com/OncBrothers/status/1979229760782770387) [@OncBrothers](/creator/x/OncBrothers) 2025-10-17T16:55Z 19.3K followers, 3384 engagements


"Day X #ESMO25 Highlights: Prostate Ca X. #PSMAddition: LuPSMA in mHSPC X. #ENZARD: ADT+XRT+/-Enza X. #EMBARK: Enza biochem recurrent Prostate Ca X. #CAPItello281: Abi+/-Capi in PTEN Mesothelioma: X. #DREAM3R: Durva+Chemo 1L #OncTwitter @OncUpdates @OncoAlert 1/11"  
[X Link](https://x.com/OncBrothers/status/1979982664716177640) [@OncBrothers](/creator/x/OncBrothers) 2025-10-19T18:47Z 19.3K followers, 12K engagements


"If/when D-FLOT (based off #MATTERHORN) was to become available and approved for all comers for PDL1 negative ( 1%) if otherwise eligible do you plan to add Durva @UGrewalMD @GIMedOnc @GIcancerDoc @rutikamehtaMD @KlempnerSam @YJanjigianMD #aoncTwitter"  
[X Link](https://x.com/OncBrothers/status/1980990045952807006) [@OncBrothers](/creator/x/OncBrothers) 2025-10-22T13:30Z 19.3K followers, 9559 engagements


"Winner winner chicken dinner Clear as mud Will wait to see what the approval label will say #MATTERHORN #gism #OncTwitter"  
[X Link](https://x.com/OncBrothers/status/1981356916816437409) [@OncBrothers](/creator/x/OncBrothers) 2025-10-23T13:47Z 19.3K followers, 3066 engagements