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# ![@yaireinhorn Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1238780417324580867.png) @yaireinhorn Yair Einhorn

Yair Einhorn posts on X about $xbi, $beam101, $lctx, $lly the most. They currently have XXXXXX followers and XX posts still getting attention that total XXXXXX engagements in the last XX hours.

### Engagements: XXXXXX [#](/creator/twitter::1238780417324580867/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1238780417324580867/c:line/m:interactions.svg)

- X Week XXXXXXX +19%
- X Month XXXXXXXXX +16%
- X Months XXXXXXXXX +15%
- X Year XXXXXXXXXX +71%

### Mentions: XX [#](/creator/twitter::1238780417324580867/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1238780417324580867/c:line/m:posts_active.svg)

- X Week XX -XX%
- X Month XXX -XX%
- X Months XXXXX -XXXX%
- X Year XXXXX +84%

### Followers: XXXXXX [#](/creator/twitter::1238780417324580867/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1238780417324580867/c:line/m:followers.svg)

- X Week XXXXXX +0.43%
- X Month XXXXXX +2.60%
- X Months XXXXXX +20%
- X Year XXXXXX +60%

### CreatorRank: XXXXXXX [#](/creator/twitter::1238780417324580867/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1238780417324580867/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[stocks](/list/stocks)  XXXXX% [finance](/list/finance)  XXXX% [technology brands](/list/technology-brands)  XXXX% [cryptocurrencies](/list/cryptocurrencies)  XXXX% [countries](/list/countries)  XXXX% [celebrities](/list/celebrities)  XXXX% [automotive brands](/list/automotive-brands)  XXXX% [currencies](/list/currencies)  XXXX% [travel destinations](/list/travel-destinations)  XXXX%

**Social topic influence**
[$xbi](/topic/$xbi) #18, [$beam101](/topic/$beam101) #1, [$lctx](/topic/$lctx) #1, [$lly](/topic/$lly) #12, [$crsp](/topic/$crsp) #3, [the first](/topic/the-first) 6.38%, [$rhhby](/topic/$rhhby) #2, [$6753t](/topic/$6753t) #1709, [$jnj](/topic/$jnj) #3, [business](/topic/business) XXXX%

**Top accounts mentioned or mentioned by**
[@lineagecell](/creator/undefined) [@unusualwhales](/creator/undefined) [@beamtx](/creator/undefined) [@biopharmiq](/creator/undefined) [@davidrlius](/creator/undefined) [@timopler](/creator/undefined) [@biomedicalrx](/creator/undefined) [@bradloncar](/creator/undefined) [@nature](/creator/undefined) [@jcannush](/creator/undefined) [@maximusholla](/creator/undefined) [@biotechch](/creator/undefined) [@tryastramd](/creator/undefined) [@davidrliu](/creator/undefined) [@cariboubio](/creator/undefined) [@eleanorolcott](/creator/undefined) [@elonmusk](/creator/undefined) [@genentech](/creator/undefined) [@hohounk](/creator/undefined) [@gregor_pck](/creator/undefined)

**Top assets mentioned**
[Bitcoin Incognito (XBI)](/topic/$xbi) [Eli Lilly and Company (LLY)](/topic/$lly) [CRISPR Therapeutics AG (CRSP)](/topic/$crsp) [Johnson & Johnson (JNJ)](/topic/$jnj) [Intellia Therapeutics, Inc (NTLA)](/topic/$ntla) [Pfizer, Inc. (PFE)](/topic/$pfe) [Novo-Nordisk (NVO)](/topic/$nvo) [Merck & Co., Inc. (MRK)](/topic/$mrk) [AbbVie Inc (ABBV)](/topic/$abbv) [BEAM (BEAM)](/topic/$beam) [Gilead Sciences, Inc. (GILD)](/topic/$gild) [Vertex Protocol (VRTX)](/topic/$vrtx) [Bristol-Myers Squibb Co (BMY)](/topic/$bmy) [Novartis AG (NVS)](/topic/$nvs) [AstraZeneca PLC (AZN)](/topic/$azn) [Synthetify (SNY)](/topic/$sny) [Adverum Biotechnologies, Inc. Common Stock (ADVM)](/topic/$advm) [NVIDIA Corp. (NVDA)](/topic/$nvda) [Tesla, Inc. (TSLA)](/topic/$tsla) [Amgen, Inc. (AMGN)](/topic/$amgn)
### Top Social Posts
Top posts by engagements in the last XX hours

"Here is an excellent answer for a question which Im asked a lot - could there be a viable business model for a one & done Gene Therapy treatment and for CRISPR companies such as $PRME $BEAM $NTLA $CRSP $CRBU $MGX $LCTX $SANA and more. During his excellent conversation with Stripes co-founder John collision in the Cheeky Pint podcast Dave Ricks - Eli Lillys CEO described $LLY recent Gene Editing asset - $VERV-102 which was acquired by Lilly as part of the Verve Theraputics acquisition 🧵👇 and also presented a new and interesting business model - a multi-year licensing model for genetic"  
[X Link](https://x.com/yaireinhorn/status/1993656480172556725)  2025-11-26T12:21Z 17.7K followers, 28.7K engagements


"5/Gileads two strongest growth engines are $GILD HIV treatments and its Oncology portfolio. In Gileads Q2 ER the company beat top-and bottom-line expectations while saying that its core HIV business is projected to generate higher revenue for the segment - mainly from its latest new launched HIV drug - Yeztugo. Oncology is also doing well with Gileads Trodelvy Antibody-Drug Conjugate - ADC and has returned to XX% growth YoY (Year over Year)"  
[X Link](https://x.com/yaireinhorn/status/1991950023630688649)  2025-11-21T19:21Z 17.7K followers, XXX engagements


"6/Gileads CAR T-cell therapy platform which are treatments that uses the patients own immune system to recognize and fight cancer tumors did not display strong business performance so far. But Gileads Anito-cel developed in collaboration with Arcellx might be the best-in-class CAR-T for multiple myeloma when it comes to market probably in 2026"  
[X Link](https://x.com/yaireinhorn/status/1991972659387580614)  2025-11-21T20:51Z 17.7K followers, XXX engagements


"Since the beginning of the year the Chinese BioTech ecosystem has experienced an exponential growth 🧵👇. But now - according to this excellent Stifels 📊 it seems that the table is turning with a sharp decline in the Hang Seng BioTech index which created a XX% performance gap compared to the American index - the $XBI. I absolutely agree with @TimOpler that the main reason causing this gap is the fact that Chinese investors are becoming ever more nervous regarding BioTech valuations on the Hong Kong stock market. Interesting to see how this plays out"  
[X Link](https://x.com/yaireinhorn/status/1994381025250533841)  2025-11-28T12:21Z 17.7K followers, 7420 engagements


"@iamyesyouareno The chart shows this clearly - Germany is lost Angela Merkel thought that Middle Eastern immigrants would replace German workers who have retired but the just opposite happened Instead of paying German pensions they are costing unprecedented sums of social security payments"  
[X Link](https://x.com/yaireinhorn/status/1994514071874396183)  2025-11-28T21:09Z 17.7K followers, 59K engagements


"Heres CNBCs great piece which explains in laymans terms what exactly is CRISPR-Cas9 interviews its co-inventor & Nobel prize winner Emmanuelle Charpentier how $CRSP transformed this Gene Editing tool into the first ever FDA approved therapy - CASGEVY & its future plans $XBI"  
[X Link](https://x.com/yaireinhorn/status/1995000929012088948)  2025-11-30T05:24Z 17.7K followers, 1380 engagements


"2/vispacabtagene regedleucel - vispa-cel formerly known as CB-010 is $CRBU most advanced allogeneic CAR-T Cell Therapy program & it is engineered by using CRISPR Cas9 hybrid RNA-DNA chRDNA technology. vispa-cel inserts a CD19-specific CAR into the TRAC gene thus knocking out PD-1 to boost the persistence of the antitumor activity. $XBI"  
[X Link](https://x.com/yaireinhorn/status/1995864423202787587)  2025-12-02T14:35Z 17.7K followers, 1060 engagements


"3/vispa-cel is an allogeneic Cell Therapy. Stem cells in allogeneic transplants derived from a healthy donor & not form the patient himself while in autologous cell therapies the cells are taken from the same person receiving the transplant - the patient is in fact his own donor"  
[X Link](https://x.com/yaireinhorn/status/1995876027940085919)  2025-12-02T15:21Z 17.7K followers, XXX engagements


"The unprecedented financial and commercial growth of the Chinese BioTech and Pharma ecosystem is undisputed. But this excellent 📊- taken from FTs comprehensive piece on the subject 🧵👇 shows IMO a much more important development - the exponential scientific progress made by the Chinese BioTech and Pharma ecosystem. From a mostly generic-manufacturing industry the Chinese BioTech ecosystem has now become a hub of innovation with an exponential growth in both clinical trials and drug R&D. The Chinese advancement was so rapid that it has long surpassed even the U.S in BioTech innovation and"  
[X Link](https://x.com/yaireinhorn/status/1996917818575491366)  2025-12-05T12:21Z 17.7K followers, 6099 engagements


"@BeamTx I have a small request to ask - If you found this post to be interesting & useful please BOOKMARK it 🧵👇so that those on who are interested in Gene editing CRISPR & BioTech will be able to access this resource. Each bookmark increases its reach by XXX times $XBI $BEAM"  
[X Link](https://x.com/yaireinhorn/status/1997630101777740149)  2025-12-07T11:31Z 17.7K followers, 1084 engagements


"@elonmusk Angela Merkel thought that Middle Eastern immigrants would replace German workers who have retired but the just opposite happened Instead of paying German pensions they are costing unprecedented sums of social security payments The chart shows this clearly - Germany is lost"  
[X Link](https://x.com/yaireinhorn/status/1997962614643827126)  2025-12-08T09:33Z 17.7K followers, 32.7K engagements


"@elonmusk This great infograph demonstrates just how dominant @elonmusk & SpaceX are in the current space industry landscape. Out of the X existing space rockets - NASAs SLS flew only once Jeff Bezos New Glenn is a prototype & electron is a toy. SpaceXs Starship & falcon X for the win"  
[X Link](https://x.com/yaireinhorn/status/1998487603675332737)  2025-12-09T20:19Z 17.7K followers, 17.1K engagements


"Ive been seeing a lot of chatter online over the last XX hours about a possible $CRSP buyout. I tend to agree with @silberschmelzer analysis👇 & would also like to remind you all that $LLY has just acquired $VERV for $1.3B so it would be unlikely for Eli Lilly to buy another CRISPR Gene Editing company. $XBI"  
[X Link](https://x.com/yaireinhorn/status/1990862931374862528)  2025-11-18T19:21Z 17.7K followers, 6813 engagements


"6/Anotner important variable in this equation is the regulatory aspect. So far The FDA has approved dozens of Gene Therapy treatments in recent years. A leading example of an approved drug is $RHHBY Luxturna - a one-time Gene Therapy treatment for inherited retinal disease caused by mutations in both copies of the RPE65 gene. Roches Luxturna works by delivering a healthy copy of the RPE65 gene into the retina via a subretinal injection to help restore vision and already cured hundreds of young patients by saving their eyesight"  
[X Link](https://x.com/yaireinhorn/status/1995211497794945528)  2025-11-30T19:21Z 17.7K followers, XXX engagements


"7/As far as Gene Editing is concerned the regulatory pathway has been somewhat slower. As of today there is only a single CRISPR Gene Editing FDA approved treatment - CASGEVY - $VRTX & $CRSP first-ever FDA approved CRISPR Gene Editing therapy for treating Sickle Cell disease and Beta-thalassemia - an inherited blood disorder where the body produces less hemoglobin the protein that carries oxygen in red blood cells"  
[X Link](https://x.com/yaireinhorn/status/1995241692971270376)  2025-11-30T21:21Z 17.7K followers, 1401 engagements


"6/These partnerships have provided the Chinese BioTech companies with much needed capital after facing a few hard years of domestic regulatory and price-control challenges. Yet there is still some uncertainty regarding these collaborations and their acceptance by western regulators such as the FDA which recently has rejected one of Hengruis cancer drug"  
[X Link](https://x.com/yaireinhorn/status/1996238396105089492)  2025-12-03T15:21Z 17.7K followers, XXX engagements


"8/This excellent Infograph shows how diverse Akeso and Hengrui pipelines really are and across all of the clinical development stages. Akeso - on top of its leading program ivonescimab has a broad pipeline across oncology autoimmune disease obesity and weight loss as well as ocular clinical candidates while Hengrui is a powerhouse of innovative as well"  
[X Link](https://x.com/yaireinhorn/status/1996313767580172477)  2025-12-03T20:21Z 17.7K followers, XXX engagements


"That is of course the billion dollar question There is one interesting case study and that is Akesos leading therapy called ivonescimab for treating cancer. While ivonescimab has successfully outperformed Mercks blockbuster drug KEYTRUDA in Chinese patients it has failed to do so among North American and European patients which raises questions about the initial dataset"  
[X Link](https://x.com/yaireinhorn/status/1996927646655984106)  2025-12-05T13:00Z 17.7K followers, XXX engagements


"1/🚨WOW Another interesting deal in the Gene Therapy space was announced yesterday with the acquisition of $ADVM by Eli Lilly in a deal valued up to $262M. As part of the acquisition $LLY will pay $ADVM shareholders $XXXX per share in cash plus contingent value rights (CVR) worth up to $XXXX per share tied to regulatory and commercial milestones for Ixo-vec - Adverum Bios leading clinical candidate which is an ocular Gene Therapy for treating wet age-related macular degeneration (wAMD)"  
[X Link](https://x.com/yaireinhorn/status/1982059849832669491)  2025-10-25T12:21Z 17.7K followers, 9463 engagements


"Here are George Washingtons eternal words from his Thanksgiving Proclamation in 1789: .to promote the knowledge and practice of true religion and virtue and the encrease of science () among them and us and generally to grant unto all Mankind such a degree of temporal prosperity. Happy thanksgiving to the greatest nation on earth who is the beacon of freedom innovation and science and to you my dear American friends on Godspeed"  
[X Link](https://x.com/yaireinhorn/status/1994071481865601059)  2025-11-27T15:51Z 17.7K followers, 3132 engagements


"@Rainmaker1973 @CrisprGlenn Heres CNBCs great piece which explains in laymans terms what exactly is CRISPR-Cas9 interviews its co-inventor & Nobel prize winner Emmanuelle Charpentier how $CRSP transformed this Gene Editing tool into the first ever FDA approved therapy - CASGEVY & its future plans $XBI"  
[X Link](https://x.com/yaireinhorn/status/1994515163714916691)  2025-11-28T21:14Z 17.7K followers, 16.4K engagements


"Here is a very interesting mention of CASGEVY - $VRTX & $CRSP first-ever FDA approved CRISPR Gene Editing therapy for treating Sickle Cell disease in the U.S.-Saudi Investment Forum which was held last week in Washington D.C and included the two most important entrepreneurs in the world today - $TSLA SpaceX and xAI CEO Elon Musk and $NVDA Founder and CEO Jensen Huang. Gene Editing has a bright future"  
[X Link](https://x.com/yaireinhorn/status/1994849238816104615)  2025-11-29T19:21Z 17.7K followers, 8600 engagements


"7/Another excellent example of the rise of the Chinese BioTech ecosystem is the Chinese BioTech company Akeso and its advanced oncology portfolio. Akesos leading therapy ivonescimab for treating cancer demonstrates the complexity and the current challenges facing the Chinese BioTech and Pharma ecosystem. While ivonescimab has successfully outperformed Mercks blockbuster drug KEYTRUDA in Chinese patients it has failed to do so among North American and European patients which made some of the investors sceptical about the initial dataset"  
[X Link](https://x.com/yaireinhorn/status/1996268464122778078)  2025-12-03T17:21Z 17.7K followers, XXX engagements


"9/The Gene Therapy field is another important therapeutic field in which the Chinese dominance is on the rise. Maybe the most important Chinese company operating in this field is Legend BioTech which had signed a significant collaboration agreement with $JNJ - as early as 2017 to develop CAR-T therapy for multiple myeloma cancer. Unlike in the U.S - in which the Gene Therapy field has suffered huge regulatory setbacks and soaring costs the Chinese regulators have been nothing but supportive of this field and even approved Carvykti - Legends and JNJ joint cancer treatment for Chinese patients"  
[X Link](https://x.com/yaireinhorn/status/1996328857083969875)  2025-12-03T21:21Z 17.7K followers, 1159 engagements


"Although it the FDA hold was expected the thing which surprised me was the fact that according to $NTLA the FDA verbally informed the Company which emphasised a sense of urgency. It was urgent enough that the FDA chose to call rather than to send Intellia an official letter. 🤔"  
[X Link](https://x.com/yaireinhorn/status/1983658927654105187)  2025-10-29T22:15Z 17.7K followers, 3001 engagements


"This excellent 📊 by Stifels @timopler shows an unprecedented XXX trillion dollars firepower at the hands of the XX biggest Pharma companies - $JNJ $RHHBY $LLY $NVO $NVS $PFE $AZN $BMY $GILD and more. The fact that all of these big Pharma companies are now facing a massive patent cliff 🧵👇- which is going to affect XX% of their total revenues over the next X years combined with this unprecedented $1.2T war chest for BioTech M&A deals suggests that we are only at the beginning of an exponential BioTech growth cycle $XBI"  
[X Link](https://x.com/yaireinhorn/status/1993293861917970444)  2025-11-25T12:21Z 17.7K followers, 68.4K engagements


"1/🚨WOW @lineagecell has announced that it has achieved the first milestone under its $RHHBY-Genentech collaboration agreement related to manufacturing and clinical development of OpRegen - $LCTX ocular Cell Therapy program 🧵👇. This event triggered a $5M milestone payment from Roche to Lineage which is expected to be received within XX days. $XBI"  
[X Link](https://x.com/yaireinhorn/status/1994018634599964845)  2025-11-27T12:21Z 17.7K followers, 9981 engagements


"2/Dry AMD is caused by the loss of retina cells - a loss which creates a geographic atrophy - GA in the eye leading to impaired vision and blindness. Its estimated that dry AMD affects millions of people worldwide with around XX million people affected in the US alone"  
[X Link](https://x.com/yaireinhorn/status/1994026337816686869)  2025-11-27T12:51Z 17.7K followers, XXX engagements


"3/@LineageCell platform is based on a unique technology that enables it to make specific cell types from a single pluripotent cell line thus creating off the shelf cell transplants platform for multiple conditions. $LCTX most advanced program is its OpRegen ocular program. $XBI"  
[X Link](https://x.com/yaireinhorn/status/1994033756189991043)  2025-11-27T13:21Z 17.7K followers, XXX engagements


"4/OpRegen (RG6501) is a Cell Therapy based on human allogeneic retinal pigment epithelial (RPE) cells currently in development by $LCTX in collaboration with $RHHBY for the treatment of GA secondary to dry AMD. Subretinal delivery of OpRegen cell therapy has the potential to counteract RPE cell loss in areas of GA lesions thus supporting retinal cell health and improving retinal structure and function"  
[X Link](https://x.com/yaireinhorn/status/1994041342750556664)  2025-11-27T13:51Z 17.7K followers, XXX engagements


"5/In December 2021 Lineage Cell has entered into a collaboration and license agreement with Genentech and Roche under which $RHHBY and Genentech are responsible for the clinical R&D and commercialisation of OpRegen (RG6501) and $LCTX is eligible for $620M of milestone payments + double-digit royalties from Roche"  
[X Link](https://x.com/yaireinhorn/status/1994063957120684062)  2025-11-27T15:21Z 17.7K followers, XXX engagements


"6/Lineage has recently presented promising and best in class data which demonstrated a dramatic and long lasting vision improvement in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). This improvement lasted XX months () after the initial and single administration of RG6501 (OpRegen) - a retinal pigment epithelial (RPE) Cell therapy aimed to treat age-related macular degeneration dry AMD to the patients eye"  
[X Link](https://x.com/yaireinhorn/status/1994124506005164161)  2025-11-27T19:21Z 17.7K followers, 1234 engagements


"@LineageCell 7/Following this super promising data - $LCTX in collaboration with Roche & @genentech have initiated a Phase 2a study - GAlette which aims to evaluate the success of subretinal delivery of OpRegen cell therapy to target areas of GA with enrolment expected for up to XX patients"  
[X Link](https://x.com/yaireinhorn/status/1994154589096947784)  2025-11-27T21:21Z 17.7K followers, 1375 engagements


"@LineageCell @genentech I have a small request - If you found this post to be interesting & useful please BOOKMARK it 🧵👇so that those on who are interested in Gene editing CRISPR & BioTech will be able to access this resource. Each bookmark increases its reach by XXX times $XBI $LCTX $RHHBY"  
[X Link](https://x.com/yaireinhorn/status/1994245105117524045)  2025-11-28T03:20Z 17.7K followers, 1195 engagements


"The exponential growth happening right now in the Chinese BioTech and Pharma ecosystem has been nothing short of spectacular. This excellent 📊- taken from FTs comprehensive piece on the subject 🧵👇shows that not only is 2025 has been a breaking-record year so far - with XX deals made by Chinese BioTech companies worth $85B in just the first X months but that this year is also predicted to hit a sixth consecutive annual record The Chinese dragon has awoken 🐉🔥 $XBI"  
[X Link](https://x.com/yaireinhorn/status/1996555382299217933)  2025-12-04T12:21Z 17.7K followers, 22.6K engagements


"Instead of trying to hurt and free speech maybe you should take a close look on this WSJ excellent 📊👇which shows a sharp & rapid decline in European innovation stance which translates into its small global share of private tech companies valued $1B - compared to the American & the Chinese share You and your policies are exactly the reason why no entrepreneur in his right mind will choose to open his company or to stay and operate in Europe"  
[X Link](https://x.com/yaireinhorn/status/1997010114943779274)  2025-12-05T18:28Z 17.7K followers, 61.3K engagements


"$NTLA has specifically stated that the FDA indicated that it would provide a formal Clinical Hold Letter within XX calendar days. I find it very wired that so far no such letter has been issued to the company and we are far beyond the designated XX days time frame"  
[X Link](https://x.com/yaireinhorn/status/1997053683800866868)  2025-12-05T21:21Z 17.7K followers, 1481 engagements


"This excellent @nature 📊👇 provides another example of the importance and the huge innovative role which small and mid-cap (SMID) BioTech companies play in the BioTech and Pharma ecosystem and how vital they are for the growth of big Pharma companies such as $LLY $NVO $JNJ $ABBV $MRK $RHHBY $NVS $AZN $AMGN $PFE and others. Out of the XXX new drugs which were approved by the FDA between 20152021 - XXX were filed for approval by the top XX Big Pharma companies. Within this group - while the largest group of small-molecule drugs (44%) originated from the big Pharma companies themselves the"  
[X Link](https://x.com/yaireinhorn/status/1998744783615889848)  2025-12-10T13:21Z 17.7K followers, 2303 engagements


"1/Heres an excellent Financial Times article which accurately describes the problematic situation which many big Pharma companies such as $PFE $JNJ $BMY $ABBV $LLY $MRK $SNY and others are now facing - the upcoming patent cliff scenario. With IP rights which are about to expire in 2027-2028 big Pharma companies face a huge pressure on both their pipeline and their future revenue streams and here is how they intend to address this burning issue. $XBI 🧵👇"  
[X Link](https://x.com/yaireinhorn/status/1947285728351920521)  2025-07-21T13:21Z 17.7K followers, 146.8K engagements


"Instead of trying to hurt and free speech maybe you should take a close look on this WSJ excellent 📊👇which shows a sharp & rapid decline in European innovation stance which translates into its small global share of private tech companies valued $1B - compared to the American & the Chinese share You and your policies are exactly the reason why no entrepreneur in his right mind will choose to open his company or to stay and operate in Europe"  
[X Link](https://x.com/yaireinhorn/status/1997010090499457253)  2025-12-05T18:28Z 17.7K followers, 27.4K engagements


"Instead of trying to hurt and free speech maybe the EU leadership should take a close look on this WSJ excellent 📊👇which shows a sharp & rapid decline in European innovation stance which translates into its small global share of private tech companies valued $1B - compared to the American & the Chinese share Eu policies are exactly the reason why no entrepreneur in his right mind will choose to open his company or to stay and operate in Europe"  
[X Link](https://x.com/yaireinhorn/status/1997285898161975476)  2025-12-06T12:44Z 17.7K followers, 29.8K engagements


"1/🚨WOW @BeamTx presented new promising data from its BEACON Phase 1/2 trial of ristoglogene autogetemcel (risto-cel) - formerly known as $BEAM-101 in patients with sickle cell disease (SCD) which demonstrated rapid and robust fetal hemoglobin HbF of more than XX% a XX% reduction in sickle hemoglobin HbS & no VOCs in SCD patients post treatment #ASH25 #ASH2025 $XBI"  
[X Link](https://x.com/yaireinhorn/status/1997295245952712813)  2025-12-06T13:21Z 17.7K followers, 16.9K engagements


"2/Sickle cell disease or SCD is a group of inherited disorders that affect hemoglobin - the major protein that carries oxygen in red blood cells. Normal blood cells (RBCs) are disc-shaped and flexible so they can move easily through the blood vessels. In sickle cell disease red blood cells are misshaped in crescent or a sickle-shaped figure due to a gene mutation that affects the hemoglobin molecule. When red blood cells sickle they do not bend or move easily and can block the patients blood flow to the rest of the body"  
[X Link](https://x.com/yaireinhorn/status/1997303065376899133)  2025-12-06T13:52Z 17.7K followers, 1088 engagements


"3/ristoglogene autogetemcel (risto-cel) - formerly known as $BEAM-101 is a patient-specific autologous hematopoietic Stem Cell (HSC) therapy which uses Base Editing to increase a patients production of non-sickling and anti-sickling fetal hemoglobin (HbF) and thus to mimic the effects of naturally occurring variants seen in hereditary persistence of fetal hemoglobin. HbF is the predominant hemoglobin variant during development and early life of a human being"  
[X Link](https://x.com/yaireinhorn/status/1997310392003973578)  2025-12-06T14:21Z 17.7K followers, 1197 engagements


"4/risto-cel or $BEAM-101 is an autologous genetically modified cell therapy. An autologous therapy means that the cells themselves are taken from an individual's own tissues cells or DNA. These cells are extracted edited outside the patients body & later restored to help fight SCD. $XBI"  
[X Link](https://x.com/yaireinhorn/status/1997318091953336632)  2025-12-06T14:51Z 17.7K followers, 1088 engagements


"5/@BeamTx is currently conducting its ongoing Phase 1/2 BEACON clinical trail which is designed to evaluate both the safety & efficacy of risto-cell / $BEAM-101 in an open-label single-arm multicenter trial in SCD adult patients with severe vaso-occlusive crises - VOCs. BEACON was also selected as part of @NatureMedicines 2025 list of XX trails which will have a significant impact on medicine in that year🧵👇"  
[X Link](https://x.com/yaireinhorn/status/1997325436066439538)  2025-12-06T15:21Z 17.7K followers, 1734 engagements


"@BeamTx 6/As of an August X 2025 - the date of the data cut-off a total of XX patients with severe SCD were treated with risto-cel - formally known as $BEAM-101 in the BEACON Phase 1/2 trial and are included in the safety and efficacy analysis. Follow-up ranged from XXX to XXXX months"  
[X Link](https://x.com/yaireinhorn/status/1997340519224000943)  2025-12-06T16:21Z 17.7K followers, 1010 engagements


"7/All of the SCD patients which were treated with risto-cel / $BEAM-101 achieved endogenous HbF levels exceeding XX% and a durable reduction in corresponding HbS below 40%. A pancellular distribution of HbF-expressing cells with HbF levels per cell above the sickling threshold was maintained through follow-up"  
[X Link](https://x.com/yaireinhorn/status/1997355642520998054)  2025-12-06T17:21Z 17.7K followers, 4803 engagements


"8/Patients achieved rapid and robust bone marrow reconstitution post-risto-cel treatment. The median time to neutrophil engraftment was XXXX days (range: 12-30) with a median duration of severe neutropenia of X days (range: 1-17). The median time to platelet engraftment was XX days (range: 11-53). In addition XX% of patients did not require any platelet transfusions following risto-cel treatment"  
[X Link](https://x.com/yaireinhorn/status/1997372478499291140)  2025-12-06T18:28Z 17.7K followers, XXX engagements


"9/A key issue which will determine whether SCD patients and physicians will actually use $BEAM-101 as a therapy for Sickle Cell depends on durability - whether BEAM-101s therapeutic potential impact is long lasting. The fact that the increase in HbF & the decreases in HbS were durable for up to XX months is highly promising IMO"  
[X Link](https://x.com/yaireinhorn/status/1997385839442325669)  2025-12-06T19:21Z 17.7K followers, 1279 engagements


"10/The safety profile of $BEAM-101 was consistent with busulfan conditioning autologous HSCT and underlying SCD. The most common treatment-emergent adverse events (TEAEs) were consistent with busulfan conditioning including stomatitis febrile neutropenia and anemia. As previously reported one patient died four months after BEAM-101 infusion due to respiratory failure that was determined by the investigator to be likely related to busulfan conditioning and deemed unrelated to BEAM-101"  
[X Link](https://x.com/yaireinhorn/status/1997416035104813359)  2025-12-06T21:21Z 17.7K followers, 1069 engagements


"11/One of the key findings was the high efficiency in cell collection and the rapid engraftment which is highly important for SCD patients. The fact that all the patients achieved the minimum target cell dose in either X or X of mobilization (average: 1.4) means fewer hospitalisation days and makes $BEAM-101 much more friendly for patients"  
[X Link](https://x.com/yaireinhorn/status/1997513968542154894)  2025-12-07T03:50Z 17.7K followers, XXX engagements


"12/This promising new data from risto-cel or $BEAM-101s BEACON trial (n=31) continues to reinforce the potential of BEAM-101 as a potential one and done treatment for Sickle Cell disease. By restoring red blood cell health and function & reducing hospital time for patients BEAM-101 could potentially decrease the overall burden for both patients and providers"  
[X Link](https://x.com/yaireinhorn/status/1997538029532045634)  2025-12-07T05:25Z 17.7K followers, 1457 engagements


"1/🚨WOW @WaveLifeSci has presented positive clinical data from its Phase X INLIGHT Trial of $WVE-007 (INHBE) for Obesity demonstrating that a single XXX mg dose of WVE-007 led to an improvement in body composition with fat loss similar to GLP-1 drugs - such as $NVO Semaglutide and $LLY tirzepatide at X months without any muscle loss WVE-007 is an investigational INHBE GalNAc-siRNA program which uses Waves proprietary SpiNA platform and is designed to treat Obesity. Todays clinical data showed that a single XXX mg dose of WVE-007 led to an improvement in body composition characterized by"  
[X Link](https://x.com/yaireinhorn/status/1998014089268773362)  2025-12-08T12:57Z 17.7K followers, 27.3K engagements


"@IterIntellectus When you walk in the streets of you dont see children at all & its really easy to notice that the population is old. Sadly the Japanese are not having children and if this wont change soon - this amazing culture will disappear (I recently took this picture in Tokyo )"  
[X Link](https://x.com/yaireinhorn/status/1998694829622984938)  2025-12-10T10:02Z 17.7K followers, 29.2K engagements


"This would be a huge mistake THE main concern of any central bank is and should always be the battle against inflation With the threat of inflation becoming ever-more serious - with growing geopolitical tensions Powell cant possibly cut interest rates because he would be fuelling inflation Its a simple as that"  
[X Link](https://x.com/yaireinhorn/status/1998783420902564150)  2025-12-10T15:54Z 17.7K followers, 1277 engagements