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# ![@esanum Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1923490283557355520.png) @esanum esanum

esanum posts on X about lcx, lima, lad, scotch the most. They currently have XXXXX followers and XX posts still getting attention that total XXXXX engagements in the last XX hours.

### Engagements: XXXXX [#](/creator/twitter::1923490283557355520/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1923490283557355520/c:line/m:interactions.svg)

- X Week XXXXXX +115%
- X Month XXXXXXX -X%

### Mentions: XX [#](/creator/twitter::1923490283557355520/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1923490283557355520/c:line/m:posts_active.svg)

- X Week XX +2.70%
- X Month XXX -XX%

### Followers: XXXXX [#](/creator/twitter::1923490283557355520/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1923490283557355520/c:line/m:followers.svg)

- X Week XXXXX +3.60%
- X Month XXXXX +22%

### CreatorRank: XXXXXXX [#](/creator/twitter::1923490283557355520/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1923490283557355520/c:line/m:influencer_rank.svg)

### Social Influence [#](/creator/twitter::1923490283557355520/influence)
---

**Social category influence**
[cryptocurrencies](/list/cryptocurrencies)  XXXX% [travel destinations](/list/travel-destinations)  XXXX% [currencies](/list/currencies)  XXXX%

**Social topic influence**
[lcx](/topic/lcx) #19, [lima](/topic/lima) 2.56%, [lad](/topic/lad) 2.56%, [scotch](/topic/scotch) 2.56%, [alt](/topic/alt) 2.56%, [loop](/topic/loop) 2.56%, [h1](/topic/h1) 2.56%, [dec](/topic/dec) 2.56%, [cox](/topic/cox) 2.56%, [txa](/topic/txa) XXXX%

**Top accounts mentioned or mentioned by**
[@doctorssquad](/creator/undefined) [@moarsahitopti](/creator/undefined) [@doctorsguild](/creator/undefined) [@trackyourheart](/creator/undefined) [@medcrux](/creator/undefined) [@simplifydrugs](/creator/undefined) [@naturemedicine](/creator/undefined) [@nervemed](/creator/undefined) [@drakhilx](/creator/undefined) [@nejm](/creator/undefined) [@karolinskainst](/creator/undefined) [@asco](/creator/undefined) [@npr](/creator/undefined) [@nprlifekit](/creator/undefined) [@aasmorg](/creator/undefined) [@drsthanus](/creator/undefined) [@jnnpbmj](/creator/undefined) [@alzresearchuk](/creator/undefined) [@dogemusk01](/creator/undefined)

**Top assets mentioned**
[LCX (LCX)](/topic/lcx)
### Top Social Posts [#](/creator/twitter::1923490283557355520/posts)
---
Top posts by engagements in the last XX hours

"ðŸ”ī Organ: Adrenal (suprarenal) gland 📍 Capsule cortex (zona glomerulosa fasciculata reticularis) central medulla 🧠 GFR: salt (aldosterone) sugar (cortisol) sex (androgens); medulla = epinephrine/norepinephrine (chromaffin) ðŸ’Ą Regulation: ZG by RAAS; ZF/ZR by ACTH; venous outflow via a large central vein"  
[X Link](https://x.com/esanum/status/1979901993595314427) [@esanum](/creator/x/esanum) 2025-10-19T13:26Z 5730 followers, 2295 engagements


"@Doctors__squad ✅ Answer: C) Factor VII 📍 Serum = plasma after clotting lacks fibrinogen ⚡ Factor VII is stable (vitamin Kdependent) and not consumed so present in both ðŸ’Ą Labile factors V & VIII and prothrombin (II) are depleted in serum"  
[X Link](https://x.com/esanum/status/1980356741499089194) [@esanum](/creator/x/esanum) 2025-10-20T19:33Z 5730 followers, XXX engagements


"@Doctors_GUILD ✅ Answer: C) Hypocalcemia 📍 Post-thyroidectomy paresthesias/tetany; Chvostek/Trousseau signs 🔷 Transient hypoparathyroidism from devascularized/removed parathyroids PTH Ca ðŸ’Ą Monitor Ca/PTH; treat with calcium calcitriol (IV if symptomatic)"  
[X Link](https://x.com/esanum/status/1973795874141843730) [@esanum](/creator/x/esanum) 2025-10-02T17:03Z 5732 followers, 2057 engagements


"✅ Answer: A) Endocardium 📍 Chordae tendineae (and AV valve leaflets) develop from endocardial cushions/subendocardial mesenchyme 🔷 Papillary muscles arise from myocardium; epicardium contributes to coronary vessels; mesocardium is transient ðŸ’Ą Valve remodeling leaves thin fibrous cords anchoring leaflets to papillary muscles"  
[X Link](https://x.com/esanum/status/1979536967806144930) [@esanum](/creator/x/esanum) 2025-10-18T13:16Z 5731 followers, 3419 engagements


"ðŸŦ€ CABG graft map (SVG) 📍 Saphenous vein grafts typically to PDA (RCA) OM (LCx) and diagonal/LAD branches ⚡ LIMA LAD is the usual workhorse for best long-term patency; SVGs have higher occlusion risk ðŸ’Ą Post-CABG: aggressive secondary prevention (antiplatelet statin BP/DM control)"  
[X Link](https://x.com/esanum/status/1980365302861885909) [@esanum](/creator/x/esanum) 2025-10-20T20:07Z 5730 followers, XX engagements


"@medcrux ✅ Answer: A) Orbicularis oris 📍 Unilateral cleft lip = failed fusion of maxillary + medial nasal processes 🧠 Repair re-approximates the orbicularis oris to restore lip sphincter/philtral contour ðŸ’Ą Timing often XX mo (Rule of 10s)"  
[X Link](https://x.com/esanum/status/1979169127299195160) [@esanum](/creator/x/esanum) 2025-10-17T12:54Z 5680 followers, XXX engagements


"@nervemed ✅ Answer: B) Scleroderma (systemic sclerosis) 📍 Perioral skin tightening with radial furrows microstomia; mask-like facies 🔷 Autoimmune fibroblast activation excess collagen ( anti-centromere/Scl-70) ðŸ’Ą Screen for Raynauds sclerodactyly telangiectasia and reflux"  
[X Link](https://x.com/esanum/status/1979169143598252436) [@esanum](/creator/x/esanum) 2025-10-17T12:54Z 5695 followers, XXX engagements


"@Doctors_GUILD ✅ Answer: C) Coffee machine 📍 24/7 availability precise dosing zero drama 🧠 Caffeine blocks adenosine (A1/A2A)  alertness fatigue ðŸ’Ą Use PRN; avoid late evening to protect sleep"  
[X Link](https://x.com/esanum/status/1979326664007127241) [@esanum](/creator/x/esanum) 2025-10-17T23:20Z 5676 followers, XXX engagements


"@MoarSahitoPTI 🧠 Why avoid NSAIDs with antihypertensives 📍 COX inhibition renal prostaglandins afferent vasoconstriction & GFR ⚡ Na/HO retention BP; blunts the effect of ACEi/ARBs and diuretics ðŸ’Ą Triple whammy: ACEi/ARB + diuretic + NSAID high AKI risk"  
[X Link](https://x.com/esanum/status/1976660976146792706) [@esanum](/creator/x/esanum) 2025-10-10T14:47Z 5715 followers, 2094 engagements


"@TrackYourHeart ✅ Answer: c) 1530% 📍 Variant third branch from the left main between LAD and LCx (ramus). 🔷 Supplies the high lateral LV wallischemia can give ST elevation in I/aVL. ðŸ’Ą Recognition matters for PCI/CABG planning; terminology varies (ramus/intermediate/median artery)"  
[X Link](https://x.com/esanum/status/1978963401960202703) [@esanum](/creator/x/esanum) 2025-10-16T23:16Z 5715 followers, XXX engagements


"@DrAkhilX ✅ Answer: Alcoholic hepatitis 📍 AST 50400 with AST/ALT XXXX (classically 2) = hallmark pattern 🔷 Alcohol mitochondrial injury AST + B6 (pyridoxine) deficiency relatively ALT 🧠 Memory hook: Alcohol ST higher than LT (S for Scotch)"  
[X Link](https://x.com/esanum/status/1979264985478889688) [@esanum](/creator/x/esanum) 2025-10-17T19:15Z 5706 followers, 2940 engagements


"ðŸ”ī Diagnosis: Pyogenic granuloma (lobular capillary hemangioma) 📍 Rapidly growing friable red papule on the lip that ulcerates/bleeds easily 🔷 Benign capillary proliferationoften triggered by minor trauma + hormonal surges (e.g. pregnancy precocious puberty) 🧠 VEGF-driven angiogenesis in the dermis ðŸ’Ą Tx: shave/excision with cautery or laser; address triggers to prevent recurrence"  
[X Link](https://x.com/esanum/status/1979265038440632782) [@esanum](/creator/x/esanum) 2025-10-17T19:15Z 5721 followers, XXX engagements


"@MoarSahitoPTI ✅ Answer: It acutely expands intravascular volume 📍 Osmotic shift pulls water into plasma transient preload/PCWP 🧠 Higher capillary hydrostatic pressure worsens alveolar flooding (esp. LV failure/anuria) ðŸ’Ą Avoid in pulmonary edema/CHF; use loop diuretics instead"  
[X Link](https://x.com/esanum/status/1979536952400793811) [@esanum](/creator/x/esanum) 2025-10-18T13:16Z 5706 followers, 4207 engagements


"ðŸ”ī Diagnosis: Dermatographism (dermatographic urticaria) 📍 Immediate linear wheals/erythema after scratching or pressure skin writing 🔷 Physical urticaria from mast-cell degranulation histamine-mediated edema; often idiopathic/atopic ðŸ’Ą Confirm by gentle stroke test; treat with non-sedating H1 antihistamines and avoid tight friction/pressure"  
[X Link](https://x.com/esanum/status/1979541959153684556) [@esanum](/creator/x/esanum) 2025-10-18T13:35Z 5712 followers, 2077 engagements


"ðŸ”ī Diagnosis: Loa loa subconjunctival migration (African eye worm) 📍 Visible migrating worm foreign-body sensation tearing; Calabar swellings West/Central Africa exposure 🔷 Deerfly (Chrysops) transmission; diurnal microfilaremia 💊 Remove the worm + diethylcarbamazine (DEC); check microfilarial load & rule out onchocerciasis (risk of encephalopathy with DEC/ivermectin if high)"  
[X Link](https://x.com/esanum/status/1973109812931207451) [@esanum](/creator/x/esanum) 2025-09-30T19:36Z 5730 followers, XXX engagements


"💊🧎 Low-dose aspirin halves 3-year CRC recurrence in PI3K-altered tumors Design: Double-blind RCT after curative surgery for stage IIII CRC; tumor PI3K-pathway alterations required. XXX mg daily for X years vs placebo. Of 2980 genotyped XX% had PI3K alterations; XXX randomized (hotspot PIK3CA exon 9/20 = group A; other PIK3CA/PIK3R1/PTEN = group B). Results: 3-year recurrence XXX% vs XXXX% (HR 0.49; XX% CI 0.240.98) in group A; XXX% vs XXXX% (HR 0.42; 0.210.83) in group B. Disease-free survival favored aspirin in both groups. Severe AEs: XXXX% aspirin vs XXXX% placebo. Clinical read: First"  
[X Link](https://x.com/esanum/status/1977992774579523908) [@esanum](/creator/x/esanum) 2025-10-14T07:00Z 5723 followers, XXX engagements


"✅ Answer: Dose-dependent COX inhibition 📍 Low dose (75100 mg): first-pass selective irreversible platelet COX-1 block TXA antiplatelet cardioprotection 📍 Higher dose: systemic COX-1/COX-2 inhibition in tissues PGE/PGI analgesic/anti-inflammatory ðŸ’Ą Platelets cant resynthesize COX once-daily low dose works; higher doses bleeding/GI risk"  
[X Link](https://x.com/esanum/status/1980028069780828192) [@esanum](/creator/x/esanum) 2025-10-19T21:47Z 5731 followers, 1677 engagements


"ðŸ˜īðŸĶī Morning aches Clinician-backed sleepposture fixes (NPR Life Kit) "Sleep the way you stand." Aim for a neutral line ear shoulder hip; avoid chin-tuck or hyperextension and keep arms symmetric. Poor overnight alignment drives muscle tension and AM soreness. Position & pillows: Back: medium-loft pillow; fill gaps (e.g. small pillow under knees) to unload lumbar spine. Side: choose loft by neck-to-shoulder distance; consider a pillow between knees or a body pillow to align hips. Stomach: generally avoid; if you must use low/no head pillow and consider a thin support under hips. Systems"  
[X Link](https://x.com/esanum/status/1980197307649061317) [@esanum](/creator/x/esanum) 2025-10-20T09:00Z 5731 followers, XXX engagements


"@drsthanus ðŸ”ī Diagnosis: Large hiatal hernia 📍 Elderly patient with dyspnea/cough ⚡ CXR: big retrocardiac airfluid level forming a rounded opacity behind the heart ðŸ’Ą Predisposes to reflux/aspiration; confirm with barium swallow/CT and manage medically or repair if symptomatic"  
[X Link](https://x.com/esanum/status/1980364148895846666) [@esanum](/creator/x/esanum) 2025-10-20T20:03Z 5731 followers, XXX engagements


"🧠ðŸĐļ Lower LDL-C linked to lower incident dementia; statins add incremental benefit (JNNP) Design: Distributed network analysis across XX university hospitals (Korea); matched adults with LDL-C XXX mmol/L (70 mg/dL) to those XXX mmol/L (130 mg/dL) (108k pairs). Lower LDL-C was associated with XX% all-cause dementia and XX% Alzheimers-related dementia. Statins & thresholds: Among those with LDL-C XXX mmol/L statin use conferred an additional XX% (all-cause) and XX% (ADRD) risk reduction; no further benefit seen XXX mmol/L (30 mg/dL) (plateau). Clinical read: Observational datano causality"  
[X Link](https://x.com/esanum/status/1977267997975740902) [@esanum](/creator/x/esanum) 2025-10-12T07:00Z 5730 followers, XXX engagements


"✅ Answer: Methemoglobinemia 📍 Central cyanosis with low SpO despite normal lungs/airway; PaO normal; chocolate-brown blood 🧠 Fe Fe (metHb) cant carry/release O; triggers: dapsone nitrates benzocaine aniline dyes ðŸ’Ą Antidote: Methylene blue XX mg/kg IV (avoid in G6PD deficiency use high-dose vitamin C)"  
[X Link](https://x.com/esanum/status/1979901978617528350) [@esanum](/creator/x/esanum) 2025-10-19T13:26Z 5731 followers, 3461 engagements


"✅ Procedure: TIPS (transjugular intrahepatic portosystemic shunt) 📍 Stent connects portal vein hepatic vein via internal jugular approach. ⚡ Indications: refractory variceal bleeding refractory ascites ( BuddChiari). 🧠 Mechanism: bypasses cirrhotic resistance  portal pressure/gradient. ⚠ Key risks: hepatic encephalopathy and shunt stenosis/dysfunction"  
[X Link](https://x.com/esanum/status/1980028013715853575) [@esanum](/creator/x/esanum) 2025-10-19T21:47Z 5731 followers, 2280 engagements


"✅ Answer: C) Lipid profile 📍 Yellow soft peri-palpebral plaques xanthelasma palpebrarum 🔷 Cholesterol-laden foam cells often linked to LDL/TG (familial or secondary) ðŸ’Ą If abnormal also screen for secondary causes (hypothyroidism diabetes cholestasis) and manage CV risk"  
[X Link](https://x.com/esanum/status/1980028054228566476) [@esanum](/creator/x/esanum) 2025-10-19T21:47Z 5731 followers, 6749 engagements


"ðŸ”ī Diagnosis: Trichostasis spinulosa 📍 Numerous pinpoint black follicular plugs over the nose (black dots) ⚡ Each plug is a tuft of retained vellus hairs in a dilated follicle (comedone-like) ðŸ’Ą Manage with extraction + topical retinoids/keratolytics; consider depilation/laser for recurrence"  
[X Link](https://x.com/esanum/status/1980365708220379377) [@esanum](/creator/x/esanum) 2025-10-20T20:09Z 5731 followers, 1574 engagements

[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]

@esanum Avatar @esanum esanum

esanum posts on X about lcx, lima, lad, scotch the most. They currently have XXXXX followers and XX posts still getting attention that total XXXXX engagements in the last XX hours.

Engagements: XXXXX #

Engagements Line Chart

  • X Week XXXXXX +115%
  • X Month XXXXXXX -X%

Mentions: XX #

Mentions Line Chart

  • X Week XX +2.70%
  • X Month XXX -XX%

Followers: XXXXX #

Followers Line Chart

  • X Week XXXXX +3.60%
  • X Month XXXXX +22%

CreatorRank: XXXXXXX #

CreatorRank Line Chart

Social Influence #


Social category influence cryptocurrencies XXXX% travel destinations XXXX% currencies XXXX%

Social topic influence lcx #19, lima 2.56%, lad 2.56%, scotch 2.56%, alt 2.56%, loop 2.56%, h1 2.56%, dec 2.56%, cox 2.56%, txa XXXX%

Top accounts mentioned or mentioned by @doctorssquad @moarsahitopti @doctorsguild @trackyourheart @medcrux @simplifydrugs @naturemedicine @nervemed @drakhilx @nejm @karolinskainst @asco @npr @nprlifekit @aasmorg @drsthanus @jnnpbmj @alzresearchuk @dogemusk01

Top assets mentioned LCX (LCX)

Top Social Posts #


Top posts by engagements in the last XX hours

"ðŸ”ī Organ: Adrenal (suprarenal) gland 📍 Capsule cortex (zona glomerulosa fasciculata reticularis) central medulla 🧠 GFR: salt (aldosterone) sugar (cortisol) sex (androgens); medulla = epinephrine/norepinephrine (chromaffin) ðŸ’Ą Regulation: ZG by RAAS; ZF/ZR by ACTH; venous outflow via a large central vein"
X Link @esanum 2025-10-19T13:26Z 5730 followers, 2295 engagements

"@Doctors__squad ✅ Answer: C) Factor VII 📍 Serum = plasma after clotting lacks fibrinogen ⚡ Factor VII is stable (vitamin Kdependent) and not consumed so present in both ðŸ’Ą Labile factors V & VIII and prothrombin (II) are depleted in serum"
X Link @esanum 2025-10-20T19:33Z 5730 followers, XXX engagements

"@Doctors_GUILD ✅ Answer: C) Hypocalcemia 📍 Post-thyroidectomy paresthesias/tetany; Chvostek/Trousseau signs 🔷 Transient hypoparathyroidism from devascularized/removed parathyroids PTH Ca ðŸ’Ą Monitor Ca/PTH; treat with calcium calcitriol (IV if symptomatic)"
X Link @esanum 2025-10-02T17:03Z 5732 followers, 2057 engagements

"✅ Answer: A) Endocardium 📍 Chordae tendineae (and AV valve leaflets) develop from endocardial cushions/subendocardial mesenchyme 🔷 Papillary muscles arise from myocardium; epicardium contributes to coronary vessels; mesocardium is transient ðŸ’Ą Valve remodeling leaves thin fibrous cords anchoring leaflets to papillary muscles"
X Link @esanum 2025-10-18T13:16Z 5731 followers, 3419 engagements

"ðŸŦ€ CABG graft map (SVG) 📍 Saphenous vein grafts typically to PDA (RCA) OM (LCx) and diagonal/LAD branches ⚡ LIMA LAD is the usual workhorse for best long-term patency; SVGs have higher occlusion risk ðŸ’Ą Post-CABG: aggressive secondary prevention (antiplatelet statin BP/DM control)"
X Link @esanum 2025-10-20T20:07Z 5730 followers, XX engagements

"@medcrux ✅ Answer: A) Orbicularis oris 📍 Unilateral cleft lip = failed fusion of maxillary + medial nasal processes 🧠 Repair re-approximates the orbicularis oris to restore lip sphincter/philtral contour ðŸ’Ą Timing often XX mo (Rule of 10s)"
X Link @esanum 2025-10-17T12:54Z 5680 followers, XXX engagements

"@nervemed ✅ Answer: B) Scleroderma (systemic sclerosis) 📍 Perioral skin tightening with radial furrows microstomia; mask-like facies 🔷 Autoimmune fibroblast activation excess collagen ( anti-centromere/Scl-70) ðŸ’Ą Screen for Raynauds sclerodactyly telangiectasia and reflux"
X Link @esanum 2025-10-17T12:54Z 5695 followers, XXX engagements

"@Doctors_GUILD ✅ Answer: C) Coffee machine 📍 24/7 availability precise dosing zero drama 🧠 Caffeine blocks adenosine (A1/A2A) alertness fatigue ðŸ’Ą Use PRN; avoid late evening to protect sleep"
X Link @esanum 2025-10-17T23:20Z 5676 followers, XXX engagements

"@MoarSahitoPTI 🧠 Why avoid NSAIDs with antihypertensives 📍 COX inhibition renal prostaglandins afferent vasoconstriction & GFR ⚡ Na/HO retention BP; blunts the effect of ACEi/ARBs and diuretics ðŸ’Ą Triple whammy: ACEi/ARB + diuretic + NSAID high AKI risk"
X Link @esanum 2025-10-10T14:47Z 5715 followers, 2094 engagements

"@TrackYourHeart ✅ Answer: c) 1530% 📍 Variant third branch from the left main between LAD and LCx (ramus). 🔷 Supplies the high lateral LV wallischemia can give ST elevation in I/aVL. ðŸ’Ą Recognition matters for PCI/CABG planning; terminology varies (ramus/intermediate/median artery)"
X Link @esanum 2025-10-16T23:16Z 5715 followers, XXX engagements

"@DrAkhilX ✅ Answer: Alcoholic hepatitis 📍 AST 50400 with AST/ALT XXXX (classically 2) = hallmark pattern 🔷 Alcohol mitochondrial injury AST + B6 (pyridoxine) deficiency relatively ALT 🧠 Memory hook: Alcohol ST higher than LT (S for Scotch)"
X Link @esanum 2025-10-17T19:15Z 5706 followers, 2940 engagements

"ðŸ”ī Diagnosis: Pyogenic granuloma (lobular capillary hemangioma) 📍 Rapidly growing friable red papule on the lip that ulcerates/bleeds easily 🔷 Benign capillary proliferationoften triggered by minor trauma + hormonal surges (e.g. pregnancy precocious puberty) 🧠 VEGF-driven angiogenesis in the dermis ðŸ’Ą Tx: shave/excision with cautery or laser; address triggers to prevent recurrence"
X Link @esanum 2025-10-17T19:15Z 5721 followers, XXX engagements

"@MoarSahitoPTI ✅ Answer: It acutely expands intravascular volume 📍 Osmotic shift pulls water into plasma transient preload/PCWP 🧠 Higher capillary hydrostatic pressure worsens alveolar flooding (esp. LV failure/anuria) ðŸ’Ą Avoid in pulmonary edema/CHF; use loop diuretics instead"
X Link @esanum 2025-10-18T13:16Z 5706 followers, 4207 engagements

"ðŸ”ī Diagnosis: Dermatographism (dermatographic urticaria) 📍 Immediate linear wheals/erythema after scratching or pressure skin writing 🔷 Physical urticaria from mast-cell degranulation histamine-mediated edema; often idiopathic/atopic ðŸ’Ą Confirm by gentle stroke test; treat with non-sedating H1 antihistamines and avoid tight friction/pressure"
X Link @esanum 2025-10-18T13:35Z 5712 followers, 2077 engagements

"ðŸ”ī Diagnosis: Loa loa subconjunctival migration (African eye worm) 📍 Visible migrating worm foreign-body sensation tearing; Calabar swellings West/Central Africa exposure 🔷 Deerfly (Chrysops) transmission; diurnal microfilaremia 💊 Remove the worm + diethylcarbamazine (DEC); check microfilarial load & rule out onchocerciasis (risk of encephalopathy with DEC/ivermectin if high)"
X Link @esanum 2025-09-30T19:36Z 5730 followers, XXX engagements

"💊🧎 Low-dose aspirin halves 3-year CRC recurrence in PI3K-altered tumors Design: Double-blind RCT after curative surgery for stage IIII CRC; tumor PI3K-pathway alterations required. XXX mg daily for X years vs placebo. Of 2980 genotyped XX% had PI3K alterations; XXX randomized (hotspot PIK3CA exon 9/20 = group A; other PIK3CA/PIK3R1/PTEN = group B). Results: 3-year recurrence XXX% vs XXXX% (HR 0.49; XX% CI 0.240.98) in group A; XXX% vs XXXX% (HR 0.42; 0.210.83) in group B. Disease-free survival favored aspirin in both groups. Severe AEs: XXXX% aspirin vs XXXX% placebo. Clinical read: First"
X Link @esanum 2025-10-14T07:00Z 5723 followers, XXX engagements

"✅ Answer: Dose-dependent COX inhibition 📍 Low dose (75100 mg): first-pass selective irreversible platelet COX-1 block TXA antiplatelet cardioprotection 📍 Higher dose: systemic COX-1/COX-2 inhibition in tissues PGE/PGI analgesic/anti-inflammatory ðŸ’Ą Platelets cant resynthesize COX once-daily low dose works; higher doses bleeding/GI risk"
X Link @esanum 2025-10-19T21:47Z 5731 followers, 1677 engagements

"ðŸ˜īðŸĶī Morning aches Clinician-backed sleepposture fixes (NPR Life Kit) "Sleep the way you stand." Aim for a neutral line ear shoulder hip; avoid chin-tuck or hyperextension and keep arms symmetric. Poor overnight alignment drives muscle tension and AM soreness. Position & pillows: Back: medium-loft pillow; fill gaps (e.g. small pillow under knees) to unload lumbar spine. Side: choose loft by neck-to-shoulder distance; consider a pillow between knees or a body pillow to align hips. Stomach: generally avoid; if you must use low/no head pillow and consider a thin support under hips. Systems"
X Link @esanum 2025-10-20T09:00Z 5731 followers, XXX engagements

"@drsthanus ðŸ”ī Diagnosis: Large hiatal hernia 📍 Elderly patient with dyspnea/cough ⚡ CXR: big retrocardiac airfluid level forming a rounded opacity behind the heart ðŸ’Ą Predisposes to reflux/aspiration; confirm with barium swallow/CT and manage medically or repair if symptomatic"
X Link @esanum 2025-10-20T20:03Z 5731 followers, XXX engagements

"🧠ðŸĐļ Lower LDL-C linked to lower incident dementia; statins add incremental benefit (JNNP) Design: Distributed network analysis across XX university hospitals (Korea); matched adults with LDL-C XXX mmol/L (70 mg/dL) to those XXX mmol/L (130 mg/dL) (108k pairs). Lower LDL-C was associated with XX% all-cause dementia and XX% Alzheimers-related dementia. Statins & thresholds: Among those with LDL-C XXX mmol/L statin use conferred an additional XX% (all-cause) and XX% (ADRD) risk reduction; no further benefit seen XXX mmol/L (30 mg/dL) (plateau). Clinical read: Observational datano causality"
X Link @esanum 2025-10-12T07:00Z 5730 followers, XXX engagements

"✅ Answer: Methemoglobinemia 📍 Central cyanosis with low SpO despite normal lungs/airway; PaO normal; chocolate-brown blood 🧠 Fe Fe (metHb) cant carry/release O; triggers: dapsone nitrates benzocaine aniline dyes ðŸ’Ą Antidote: Methylene blue XX mg/kg IV (avoid in G6PD deficiency use high-dose vitamin C)"
X Link @esanum 2025-10-19T13:26Z 5731 followers, 3461 engagements

"✅ Procedure: TIPS (transjugular intrahepatic portosystemic shunt) 📍 Stent connects portal vein hepatic vein via internal jugular approach. ⚡ Indications: refractory variceal bleeding refractory ascites ( BuddChiari). 🧠 Mechanism: bypasses cirrhotic resistance portal pressure/gradient. ⚠ Key risks: hepatic encephalopathy and shunt stenosis/dysfunction"
X Link @esanum 2025-10-19T21:47Z 5731 followers, 2280 engagements

"✅ Answer: C) Lipid profile 📍 Yellow soft peri-palpebral plaques xanthelasma palpebrarum 🔷 Cholesterol-laden foam cells often linked to LDL/TG (familial or secondary) ðŸ’Ą If abnormal also screen for secondary causes (hypothyroidism diabetes cholestasis) and manage CV risk"
X Link @esanum 2025-10-19T21:47Z 5731 followers, 6749 engagements

"ðŸ”ī Diagnosis: Trichostasis spinulosa 📍 Numerous pinpoint black follicular plugs over the nose (black dots) ⚡ Each plug is a tuft of retained vellus hairs in a dilated follicle (comedone-like) ðŸ’Ą Manage with extraction + topical retinoids/keratolytics; consider depilation/laser for recurrence"
X Link @esanum 2025-10-20T20:09Z 5731 followers, 1574 engagements

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