[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.] #  @davidasinclair David Sinclair David Sinclair posts on X about theory, guess, bmi, cascade the most. They currently have XXXXXXX followers and XX posts still getting attention that total XXXXXXX engagements in the last XX hours. ### Engagements: XXXXXXX [#](/creator/twitter::520445177/interactions)  - X Week XXXXXXXXX +26% - X Month XXXXXXXXX +2.30% - X Months XXXXXXXXXX +32% - X Year XXXXXXXXXX +317% ### Mentions: XX [#](/creator/twitter::520445177/posts_active)  - X Month XX -XX% - X Months XXX +24% - X Year XXX +333% ### Followers: XXXXXXX [#](/creator/twitter::520445177/followers)  - X Week XXXXXXX +0.43% - X Month XXXXXXX +1.10% - X Months XXXXXXX +5.60% - X Year XXXXXXX +12% ### CreatorRank: XXXXXX [#](/creator/twitter::520445177/influencer_rank)  ### Social Influence **Social category influence** [currencies](/list/currencies) #649 [stocks](/list/stocks) XXXX% [exchanges](/list/exchanges) XXXX% [technology brands](/list/technology-brands) XXXX% [countries](/list/countries) XXXX% **Social topic influence** [theory](/topic/theory) #984, [guess](/topic/guess) 4.35%, [bmi](/topic/bmi) 2.17%, [cascade](/topic/cascade) 2.17%, [future](/topic/future) 2.17%, [health](/topic/health) 2.17%, [coinbase](/topic/coinbase) 2.17%, [matter](/topic/matter) 2.17%, [events](/topic/events) 2.17%, [if you](/topic/if-you) XXXX% **Top accounts mentioned or mentioned by** [@grok](/creator/undefined) [@dont___die](/creator/undefined) [@salimahmed0](/creator/undefined) [@deathlyharvest](/creator/undefined) [@future_n_stuff](/creator/undefined) [@oughtaknow10](/creator/undefined) [@anguscooney](/creator/undefined) [@true_witness_](/creator/undefined) [@derecktafuma](/creator/undefined) [@bioprotocoleco](/creator/undefined) [@jhochderffer](/creator/undefined) [@liathetrader](/creator/undefined) [@dirtyharri27835](/creator/undefined) [@yryanlu](/creator/undefined) [@brianarmstrong](/creator/undefined) [@coinbase](/creator/undefined) [@cellmetabolism](/creator/undefined) [@biluhuang](/creator/undefined) [@jasonwilliamsmd](/creator/undefined) [@itsjoshdong](/creator/undefined) **Top assets mentioned** [Coinbase Global, Inc. (COIN)](/topic/coinbase) ### Top Social Posts Top posts by engagements in the last XX hours "New Review: Biological or epigenetic age is accelerated by severe stressors such as pregnancy followed by only partial recovery" [X Link](https://x.com/davidasinclair/status/1996900104260014170) 2025-12-05T11:11Z 515.6K followers, 761.8K engagements "Mitochondria have their own genomes. New study shows mitochondrial DNA content increases with age especially over XX & linked to methylation changes on both mitochondrial and nuclear DNA. Fascinating data that fits well with the Information Theory of Aging (ITOA). 🧵" [X Link](https://x.com/davidasinclair/status/1999921672045130206) 2025-12-13T19:17Z 515.6K followers, 75.1K engagements "Less than X hours of sleep is associated with XX% higher mortality Too much (89 hours) can raise it up to XX% The sweet spot for most people is XX hours" [X Link](https://x.com/davidasinclair/status/1996986175978959249) 2025-12-05T16:53Z 515.6K followers, 187K engagements "Reaching XX without high blood pressure high cholesterol diabetes smoking or abnormal BMI can add over XX extra years free of cardiovascular disease" [X Link](https://x.com/davidasinclair/status/1998195627411607830) 2025-12-09T00:58Z 515.6K followers, 45.6K engagements "Reaching XX without high blood pressure high cholesterol diabetes smoking or abnormal BMI can add over XX extra years free of cardiovascular disease" [X Link](https://x.com/davidasinclair/status/1998772706599137350) 2025-12-10T15:12Z 515.6K followers, 31.9K engagements "Youre watching the effect of age reversal Guess what it is" [X Link](https://x.com/davidasinclair/status/1998966523776385107) 2025-12-11T04:02Z 515.6K followers, 270.2K engagements "In 2012 we showed mitchondrial and nuclear genes become out of sync with aging and this reduces the mitochondrial activity and cellular energy - so maintaining synchonicity is important" [X Link](https://x.com/davidasinclair/status/1999921685877997831) 2025-12-13T19:17Z 515.6K followers, 4320 engagements "In short mitochondrial changes in aging arent random. Theyre part of a predictable cascade triggered by epigenetic noise. And this new paper adds another piece of evidence that aging begins upstream in the information layer" [X Link](https://x.com/davidasinclair/status/1999921687685439518) 2025-12-13T19:17Z 515.6K followers, 12.7K engagements "Youre looking at the future" [X Link](https://x.com/davidasinclair/status/2000458580684931504) 2025-12-15T06:51Z 515.6K followers, 360.7K engagements "New paper: Aspartame a synthetic dipeptide 200X sweeter than sugar is linked to heart disease and Type X diabetes. New paper finds aspartame binds tightly & stably to PGC-1alpha a key regulator of muscle health inflammation and insulin resistance 🧵" [X Link](https://x.com/davidasinclair/status/2000582793051443630) 2025-12-15T15:04Z 515.6K followers, 194.3K engagements "Pancreatic cancer has a 5-year survival of only 13%. Often driven by KRASG12D mutations. New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or help treat cancer patients 🧵" [X Link](https://x.com/davidasinclair/status/2000600872829755436) 2025-12-15T16:16Z 515.6K followers, 55.5K engagements "NewLimit an epigenetic reprogramming "age-reversal" company cofounded by @brian_armstrong @coinbase plans to advance its drug candidate into human clinical trials in the next few years" [X Link](https://x.com/davidasinclair/status/1995605212044894373) 2025-12-01T21:25Z 515.1K followers, 41.8K engagements "Sitting X h/day may account for XXX% of all deaths worldwideover 400000 deaths/year. Micro-movements matter (Rezende et al. Am J Prev Med 2016)" [X Link](https://x.com/davidasinclair/status/1996597619150237766) 2025-12-04T15:09Z 514.9K followers, 39.9K engagements "Irregular bedtimes raised the risk of major cardiovascular events by XX% even with similar total sleep. Go to bed at roughly the same time if you can. Your arteries notice" [X Link](https://x.com/davidasinclair/status/1997332455947174297) 2025-12-06T15:49Z 515.5K followers, 74.7K engagements "After studying and training for 25+ years for little to no pay my science colleagues still work X days a week XX months a year for relatively little pay much of it pro bono. Yes its flexible work but to suggest its easy is pure ignorance" [X Link](https://x.com/davidasinclair/status/1997784442111471946) 2025-12-07T21:45Z 515.6K followers, 97.9K engagements "New article: The Information Theory of Aging (ITOA) states that epigenetic drift is a cause of aging with cells taking up new identities. New review says slowing a process called "mesenchymal drift" has emerged as is a new strategy for rejuvenation" [X Link](https://x.com/davidasinclair/status/1995957914327285870) 2025-12-02T20:47Z 515.6K followers, 54.4K engagements "Exciting new paper on aging: X. CRISPR-mediated DNA breaks cause heritable epigenetic changes X. Changes occur genome-wide not just at breaks X. Natural DNA breaks also disrupt the epigenome Strongly supports The Information Theory of Aging (ITOA)" [X Link](https://x.com/davidasinclair/status/1996963237443621264) 2025-12-05T15:21Z 515.5K followers, 30.3K engagements "Women who followed a Mediterranean diet for XX years had XX% lower mortality lower inflammation and better insulin sensitivity. (Ahmad et al. JAMA Netw Open 2024)" [X Link](https://x.com/davidasinclair/status/1997698875319095680) 2025-12-07T16:05Z 515.5K followers, 35.4K engagements "People with strong social ties have XX% higher odds of survival. Being isolated can be as harmful as smoking up to XX cigarettes/day. And no your smoke break friend does not cut it" [X Link](https://x.com/davidasinclair/status/1998070575193850223) 2025-12-08T16:42Z 515.5K followers, 33.7K engagements ".@grok is wrong" [X Link](https://x.com/davidasinclair/status/1998258424107446335) 2025-12-09T05:08Z 515.5K followers, 127.7K engagements "I believe that aging is a disease. I believe it is treatable. I believe we can treat it within our lifetimes. page XX Lifespan" [X Link](https://x.com/davidasinclair/status/1998667771543003207) 2025-12-10T08:15Z 515.6K followers, 30.8K engagements "Yet you can generate multiple generations of healthy young animals from stem cells made from an adults cells (iPSCs) even an old adult 🤔 Epigenetic reset a week after fertilization is the answer - and IMHO will be the answer to safe age reversal" [X Link](https://x.com/davidasinclair/status/1998766344624312615) 2025-12-10T14:46Z 515.6K followers, 42.8K engagements "Epigenetics can't be ignored in aging or in cancer: An exciting @Nature paper suggests that fasting doesnt just shift the metabolism of breast tumors it epigenetically reprograms them dramatically enhancing endocrine therapy. This could change how we treat breast cancer. 🧵" [X Link](https://x.com/davidasinclair/status/1999103405587861879) 2025-12-11T13:06Z 515.6K followers, 54.8K engagements "These are neurons firing again in a human brain cerebral organoid that's been epigenetically rejuvenated using one of our lab's age-reversal chemical treatments" [X Link](https://x.com/davidasinclair/status/1999104006040297584) 2025-12-11T13:08Z 515.6K followers, 27.2K engagements "Old neurons firing again in a mini-human brain grown in a dish known as a cerebral organoid. The brain tissue has been rejuvenated by our lab's latest epigenetic age reversal treatment" [X Link](https://x.com/davidasinclair/status/1999112783242088782) 2025-12-11T13:43Z 515.6K followers, 78.7K engagements "45% of dementia cases could be prevented or delayed by addressing XX lifestyle factors What factors Education hearing loss BP smoking obesity depression inactivity diabetes alcohol consumption brain injury pollution isolation LDL and vision loss" [X Link](https://x.com/davidasinclair/status/1999134330052841971) 2025-12-11T15:09Z 515.6K followers, 66.3K engagements "7000 steps/day is linked to a XX% lower risk of death vs 2000. Its not magic just movement" [X Link](https://x.com/davidasinclair/status/1999252104431419601) 2025-12-11T22:57Z 515.6K followers, 134K engagements "@Wisdom_HQ Hire more scientists to work on aging" [X Link](https://x.com/davidasinclair/status/2000007241509077217) 2025-12-14T00:57Z 515.6K followers, 15.1K engagements "Heartbroken by the news from Bondi Beach where shooters killed XX people at a Hanukkah celebration. Shootings in Australia have been rare since the nation turned in their guns XX years ago" [X Link](https://x.com/davidasinclair/status/2000216266624094700) 2025-12-14T14:48Z 515.6K followers, 79.5K engagements "A new review contrasts results in humans for PQQ and NAD precursors (NMN/NR): NMN/NR support sirtuins DNA repair and metabolic resilience. PQQ acts on mitochondrial biogenesis redox control and inflammation Possible combination is discussed" [X Link](https://x.com/davidasinclair/status/2000291591987376368) 2025-12-14T19:47Z 515.6K followers, 31.1K engagements "The most unspoken workout" [X Link](https://x.com/davidasinclair/status/2000459325806919767) 2025-12-15T06:54Z 515.6K followers, 194K engagements "NAD boosting reduces senescence & inflammation in umbilical mesenchymal stromal cells (MSCs) enhancing their ability to prevent mouse muscle atrophy & improve grip strength endurance & muscle mass 🐁💪" [X Link](https://x.com/davidasinclair/status/2000678121297633367) 2025-12-15T21:23Z 515.6K followers, 22.4K engagements
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
@davidasinclair David Sinclair
David Sinclair posts on X about theory, guess, bmi, cascade the most. They currently have XXXXXXX followers and XX posts still getting attention that total XXXXXXX engagements in the last XX hours.
Engagements: XXXXXXX #
- X Week XXXXXXXXX +26%
- X Month XXXXXXXXX +2.30%
- X Months XXXXXXXXXX +32%
- X Year XXXXXXXXXX +317%
Mentions: XX #
- X Month XX -XX%
- X Months XXX +24%
- X Year XXX +333%
Followers: XXXXXXX #
- X Week XXXXXXX +0.43%
- X Month XXXXXXX +1.10%
- X Months XXXXXXX +5.60%
- X Year XXXXXXX +12%
CreatorRank: XXXXXX #
Social Influence
Social category influence currencies #649 stocks XXXX% exchanges XXXX% technology brands XXXX% countries XXXX%
Social topic influence theory #984, guess 4.35%, bmi 2.17%, cascade 2.17%, future 2.17%, health 2.17%, coinbase 2.17%, matter 2.17%, events 2.17%, if you XXXX%
Top accounts mentioned or mentioned by @grok @dont___die @salimahmed0 @deathlyharvest @future_n_stuff @oughtaknow10 @anguscooney @true_witness_ @derecktafuma @bioprotocoleco @jhochderffer @liathetrader @dirtyharri27835 @yryanlu @brianarmstrong @coinbase @cellmetabolism @biluhuang @jasonwilliamsmd @itsjoshdong
Top assets mentioned Coinbase Global, Inc. (COIN)
Top Social Posts
Top posts by engagements in the last XX hours
"New Review: Biological or epigenetic age is accelerated by severe stressors such as pregnancy followed by only partial recovery"
X Link 2025-12-05T11:11Z 515.6K followers, 761.8K engagements
"Mitochondria have their own genomes. New study shows mitochondrial DNA content increases with age especially over XX & linked to methylation changes on both mitochondrial and nuclear DNA. Fascinating data that fits well with the Information Theory of Aging (ITOA). 🧵"
X Link 2025-12-13T19:17Z 515.6K followers, 75.1K engagements
"Less than X hours of sleep is associated with XX% higher mortality Too much (89 hours) can raise it up to XX% The sweet spot for most people is XX hours"
X Link 2025-12-05T16:53Z 515.6K followers, 187K engagements
"Reaching XX without high blood pressure high cholesterol diabetes smoking or abnormal BMI can add over XX extra years free of cardiovascular disease"
X Link 2025-12-09T00:58Z 515.6K followers, 45.6K engagements
"Reaching XX without high blood pressure high cholesterol diabetes smoking or abnormal BMI can add over XX extra years free of cardiovascular disease"
X Link 2025-12-10T15:12Z 515.6K followers, 31.9K engagements
"Youre watching the effect of age reversal Guess what it is"
X Link 2025-12-11T04:02Z 515.6K followers, 270.2K engagements
"In 2012 we showed mitchondrial and nuclear genes become out of sync with aging and this reduces the mitochondrial activity and cellular energy - so maintaining synchonicity is important"
X Link 2025-12-13T19:17Z 515.6K followers, 4320 engagements
"In short mitochondrial changes in aging arent random. Theyre part of a predictable cascade triggered by epigenetic noise. And this new paper adds another piece of evidence that aging begins upstream in the information layer"
X Link 2025-12-13T19:17Z 515.6K followers, 12.7K engagements
"Youre looking at the future"
X Link 2025-12-15T06:51Z 515.6K followers, 360.7K engagements
"New paper: Aspartame a synthetic dipeptide 200X sweeter than sugar is linked to heart disease and Type X diabetes. New paper finds aspartame binds tightly & stably to PGC-1alpha a key regulator of muscle health inflammation and insulin resistance 🧵"
X Link 2025-12-15T15:04Z 515.6K followers, 194.3K engagements
"Pancreatic cancer has a 5-year survival of only 13%. Often driven by KRASG12D mutations. New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or help treat cancer patients 🧵"
X Link 2025-12-15T16:16Z 515.6K followers, 55.5K engagements
"NewLimit an epigenetic reprogramming "age-reversal" company cofounded by @brian_armstrong @coinbase plans to advance its drug candidate into human clinical trials in the next few years"
X Link 2025-12-01T21:25Z 515.1K followers, 41.8K engagements
"Sitting X h/day may account for XXX% of all deaths worldwideover 400000 deaths/year. Micro-movements matter (Rezende et al. Am J Prev Med 2016)"
X Link 2025-12-04T15:09Z 514.9K followers, 39.9K engagements
"Irregular bedtimes raised the risk of major cardiovascular events by XX% even with similar total sleep. Go to bed at roughly the same time if you can. Your arteries notice"
X Link 2025-12-06T15:49Z 515.5K followers, 74.7K engagements
"After studying and training for 25+ years for little to no pay my science colleagues still work X days a week XX months a year for relatively little pay much of it pro bono. Yes its flexible work but to suggest its easy is pure ignorance"
X Link 2025-12-07T21:45Z 515.6K followers, 97.9K engagements
"New article: The Information Theory of Aging (ITOA) states that epigenetic drift is a cause of aging with cells taking up new identities. New review says slowing a process called "mesenchymal drift" has emerged as is a new strategy for rejuvenation"
X Link 2025-12-02T20:47Z 515.6K followers, 54.4K engagements
"Exciting new paper on aging: X. CRISPR-mediated DNA breaks cause heritable epigenetic changes X. Changes occur genome-wide not just at breaks X. Natural DNA breaks also disrupt the epigenome Strongly supports The Information Theory of Aging (ITOA)"
X Link 2025-12-05T15:21Z 515.5K followers, 30.3K engagements
"Women who followed a Mediterranean diet for XX years had XX% lower mortality lower inflammation and better insulin sensitivity. (Ahmad et al. JAMA Netw Open 2024)"
X Link 2025-12-07T16:05Z 515.5K followers, 35.4K engagements
"People with strong social ties have XX% higher odds of survival. Being isolated can be as harmful as smoking up to XX cigarettes/day. And no your smoke break friend does not cut it"
X Link 2025-12-08T16:42Z 515.5K followers, 33.7K engagements
".@grok is wrong"
X Link 2025-12-09T05:08Z 515.5K followers, 127.7K engagements
"I believe that aging is a disease. I believe it is treatable. I believe we can treat it within our lifetimes. page XX Lifespan"
X Link 2025-12-10T08:15Z 515.6K followers, 30.8K engagements
"Yet you can generate multiple generations of healthy young animals from stem cells made from an adults cells (iPSCs) even an old adult 🤔 Epigenetic reset a week after fertilization is the answer - and IMHO will be the answer to safe age reversal"
X Link 2025-12-10T14:46Z 515.6K followers, 42.8K engagements
"Epigenetics can't be ignored in aging or in cancer: An exciting @Nature paper suggests that fasting doesnt just shift the metabolism of breast tumors it epigenetically reprograms them dramatically enhancing endocrine therapy. This could change how we treat breast cancer. 🧵"
X Link 2025-12-11T13:06Z 515.6K followers, 54.8K engagements
"These are neurons firing again in a human brain cerebral organoid that's been epigenetically rejuvenated using one of our lab's age-reversal chemical treatments"
X Link 2025-12-11T13:08Z 515.6K followers, 27.2K engagements
"Old neurons firing again in a mini-human brain grown in a dish known as a cerebral organoid. The brain tissue has been rejuvenated by our lab's latest epigenetic age reversal treatment"
X Link 2025-12-11T13:43Z 515.6K followers, 78.7K engagements
"45% of dementia cases could be prevented or delayed by addressing XX lifestyle factors What factors Education hearing loss BP smoking obesity depression inactivity diabetes alcohol consumption brain injury pollution isolation LDL and vision loss"
X Link 2025-12-11T15:09Z 515.6K followers, 66.3K engagements
"7000 steps/day is linked to a XX% lower risk of death vs 2000. Its not magic just movement"
X Link 2025-12-11T22:57Z 515.6K followers, 134K engagements
"@Wisdom_HQ Hire more scientists to work on aging"
X Link 2025-12-14T00:57Z 515.6K followers, 15.1K engagements
"Heartbroken by the news from Bondi Beach where shooters killed XX people at a Hanukkah celebration. Shootings in Australia have been rare since the nation turned in their guns XX years ago"
X Link 2025-12-14T14:48Z 515.6K followers, 79.5K engagements
"A new review contrasts results in humans for PQQ and NAD precursors (NMN/NR): NMN/NR support sirtuins DNA repair and metabolic resilience. PQQ acts on mitochondrial biogenesis redox control and inflammation Possible combination is discussed"
X Link 2025-12-14T19:47Z 515.6K followers, 31.1K engagements
"The most unspoken workout"
X Link 2025-12-15T06:54Z 515.6K followers, 194K engagements
"NAD boosting reduces senescence & inflammation in umbilical mesenchymal stromal cells (MSCs) enhancing their ability to prevent mouse muscle atrophy & improve grip strength endurance & muscle mass 🐁💪"
X Link 2025-12-15T21:23Z 515.6K followers, 22.4K engagements