# ![@andrewcaravello Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::244291506.png) @andrewcaravello Andrew Caravello, DO

Andrew Caravello, DO posts on X about $nwbo, $mrk, the world, in the the most. They currently have [---------] followers and [---] posts still getting attention that total [---------] engagements in the last [--] hours.

### Engagements: [---------] [#](/creator/twitter::244291506/interactions)
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- [--] Month [-------] +356%
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- [--] Year [---------] +1,146%

### Mentions: [--] [#](/creator/twitter::244291506/posts_active)
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- [--] Week [---] +117%
- [--] Month [---] +192%
- [--] Months [---] +70%
- [--] Year [---] +2,138%

### Followers: [---------] [#](/creator/twitter::244291506/followers)
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- [--] Week [-----] +0.46%
- [--] Month [-----] +2.70%
- [--] Months [-----] +32%
- [--] Year [-----] +220%

### CreatorRank: [-------] [#](/creator/twitter::244291506/influencer_rank)
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### Social Influence

**Social category influence**
[stocks](/list/stocks)  16.18% [finance](/list/finance)  8.09% [cryptocurrencies](/list/cryptocurrencies)  4.41% [travel destinations](/list/travel-destinations)  4.41% [currencies](/list/currencies)  3.68% [technology brands](/list/technology-brands)  1.47% [exchanges](/list/exchanges)  0.74% [automotive brands](/list/automotive-brands)  0.74%

**Social topic influence**
[$nwbo](/topic/$nwbo) #3, [$mrk](/topic/$mrk) #51, [the world](/topic/the-world) 6.62%, [in the](/topic/in-the) 6.62%, [the first](/topic/the-first) 4.41%, [london](/topic/london) 4.41%, [this is](/topic/this-is) 4.41%, [apc](/topic/apc) #157, [$gme](/topic/$gme) 3.68%, [gme](/topic/gme) 3.68%

**Top accounts mentioned or mentioned by**
[@grok](/creator/undefined) [@andrewcaravello](/creator/undefined) [@michaeljburry](/creator/undefined) [@tigontalker](/creator/undefined) [@investisco](/creator/undefined) [@theroaringkitty](/creator/undefined) [@thomasowenmcca1](/creator/undefined) [@wallstreetbets](/creator/undefined) [@drmlernermdphd](/creator/undefined) [@berlinergy](/creator/undefined) [@tommybaxendale](/creator/undefined) [@tosdd20](/creator/undefined) [@flatearthbarbie](/creator/undefined) [@aoevcbreakthru](/creator/undefined) [@kshaughnessy2](/creator/undefined) [@ucla](/creator/undefined) [@stonkmasterj](/creator/undefined) [@d_stock07734](/creator/undefined) [@michael48826289](/creator/undefined) [@stevenbremmd](/creator/undefined)

**Top assets mentioned**
[Merck & Co., Inc. (MRK)](/topic/$mrk) [GameStop, Corp. (GME)](/topic/$gme) [AstraZeneca PLC (AZN)](/topic/$azn) [Amgen, Inc. (AMGN)](/topic/$amgn) [Thermo Fisher Scientific Inc. (TMO)](/topic/$tmo) [AMC Entertainment Holdings, Inc. (AMC)](/topic/$amc) [ImmunityBio, Inc. Common Stock (IBRX)](/topic/$ibrx) [Polymesh (POLYX)](/topic/polymesh) [Pfizer, Inc. (PFE)](/topic/$pfe) [Regeneron Pharmaceuticals Inc (REGN)](/topic/$regn) [Bristol-Myers Squibb Co (BMY)](/topic/$bmy)
### Top Social Posts
Top posts by engagements in the last [--] hours

"🧬 The Trojan Vault: How $NWBO #DCVax HealthBank Could Quietly Rewire Medicine 🕰 Prologue: The Second Birth Industry The first time humanity began storing itself it wasnt to cheat death but to guard against it. In the early 2000s parents around the world began paying private firms to freeze their newborns umbilical cords. Cord blood banking was marketed as biological insurance: a hedge against diseases that might one day strike. It was a modest investmentabout two thousand dollars up front a few hundred a year after that. The odds of ever using those stem cells were infinitesimal one in tens"  
[X Link](https://x.com/andrewcaravello/status/1980042375465734562)  2025-10-19T22:44Z [----] followers, [----] engagements


"James Van Der Beeks story does not begin as a tragedy. It begins as a life that looks from the outside like it has already survived the hard part. Fame. Work. A wife. Six children. A public face that millions recognize on sight. Then colorectal cancer arrives. And the rules change. He dies at [--]. He leaves behind Kimberly and their six children. Six children is not a statistic. It is six separate mornings that still need to happen. Six lunches packed. Six backpacks by the door. Six bedtimes where a parent is expected to sound calm even when fear is loud. Cancer does not simply attack tissue."  
[X Link](https://x.com/andrewcaravello/status/2021968294060679276)  2026-02-12T15:23Z [----] followers, [----] engagements


"🧬 The Trojan Vault: How $NWBO #DCVax #HealthBank Turns Tumor Banking Into Immune Infrastructure 📌 TLDR 🧊 HealthBank is not storage. It is custody. Tumor tissue preserved in viable format under regulated chain of identity becomes therapeutic-grade starting material. 🧬 DCVax has Phase III survival data in glioblastoma. Commercial manufacturing is licensed in the UK and expanding. Automation is advancing. 🏭 Vault + Licensed Factory = Deployment Engine. Stored tumors can move directly into GMP manufacturing without rebuilding identity or supply chain. 🔁 Subscription economics mirror cord"  
[X Link](https://x.com/andrewcaravello/status/2022862717460099072)  2026-02-15T02:37Z [----] followers, [----] engagements


"$NWBO $MRK A Theory Worth Considering: What If Merck and NWBO Joined Forces Post-Approval This isnt a prediction. Its not a leak. Its not investment advice. Its a theory rooted in logic market timing and the accelerating shift in oncology. With NWBOs DCVax-L potentially nearing approval by the UKs MHRA and Mercks stock trading at a relative low the conditions are emerging for a transformative alignment not a typical buyout but a merger of mutual need and global opportunity. One has the platform. The other has the infrastructure. Together they could build something neither could do alone."  
[X Link](https://x.com/andrewcaravello/status/1925935568208171445)  2025-05-23T15:23Z [----] followers, 12.7K engagements


"🔥 The Biggest Short: How $NWBO #DCVax Exposes a Market Rigged Like [----] @MichaelJBurry__ $GME vs #NWBO @TheRoaringKitty From meme-stock mayhem to a cancer therapys fight for fair value How a @wallstreetbets short squeeze became a moviewhile a cancer breakthroughs struggle against market manipulation became a federal court case. 🎬 Introduction From Subprime to Spoofing In [----] Adam McKays The Big Short took audiences inside the surreal world of the U.S. housing bubble. Michael Lewiss book and McKays film showed how a few contrarian investors like Michael Burry pieced together what the world"  
[X Link](https://x.com/andrewcaravello/status/1958775352995848290)  2025-08-22T06:16Z [----] followers, 21.3K engagements


"🔥🔒 The Inverse Lock-Up: How $NWBO #DCVax Approval Unleashes a Scarcity Shock #BiggestShort #InverseLockUp $GME $AMC made headlines. #NWBO was kept in silence. One was a meme-stock spectacle. The other is the biggest short hiding in plain sight. @wallstreetbets @MichaelJBurry__ GameStop was loud a visible squeeze that turned into cinema. NWBO is quiet a suppressed float where approval collides with science. GameStop ended as cinema. NWBO begins as precedent. 🌍 Science and Silence Northwest Biotherapeutics is not just another biotech ticker. Its dendritic cell vaccine DCVax-L has done what"  
[X Link](https://x.com/andrewcaravello/status/1959498521431695465)  2025-08-24T06:10Z [----] followers, [----] engagements


"@StevenBremMD Dr. Brem your perspective means a great deal. To see someone of your experience speak about the journey of $NWBO and DCVax with such clarity is both grounding and inspiring 🙏🏻"  
[X Link](https://x.com/andrewcaravello/status/1962269231677861947)  2025-08-31T21:40Z [----] followers, [----] engagements


"❄ The Hidden Architecture Part [--] of [--] When the Machine Switches On The $TMO Thermal and Industrial Gates of $MRK $EIKN $AMGN #Zeon and the $NWBO #DCVax Immune Operating System 🏭 [--] The Precision Fit For Advent and Northwest Biotherapeutics Zeons role has always felt inevitable. Flaskworks greatest mechanical obstacle dendritic cells adhering to vessel walls like barnacles was the very problem Zeon had already solved through material science. Zeons proprietary polymers ZEONEX and ZEONOR are hydrophilic protein-repellent chemically stable and cryo-safe to minus [---] degrees Celsius. These films"  
[X Link](https://x.com/andrewcaravello/status/1984303713150706153)  2025-10-31T16:57Z [----] followers, [----] engagements


"🧬 $NWBO Q3 filing reveals a major operational #DCVax milestone: the company has chosen its U.S. GMP manufacturing site after evaluating two qualified facilities and has already entered contract negotiations and begun staffing the build-out. This is the quiet concrete work that marks a company preparing to operate. 🧬🔥 THE QUIET INFLECTION: How $NWBO Q3 [----] Filing Reveals a Company Moving From Development to Deployment A Global Forensic Deep-Read for Investors TLDR Northwest Biotherapeutics Q3 [----] Form 10-Q shows a company crossing a structural threshold. Without stating it outright 🧬🔥"  
[X Link](https://x.com/andrewcaravello/status/1989476355403133060)  2025-11-14T23:31Z [----] followers, [----] engagements


"🧱 Tokenizing Trust: Why $NWBO Should Build On Polymesh for Investor Protection Market Integrity IP Security and Long-Term Capital Access TLDR Tokenization is no longer a fringe idea or a crypto experiment. It is becoming a mainstream modernization of traditional market infrastructure but only when executed within the full regulatory framework that governs U S securities. SIFMA the primary policy voice of broker-dealers investment banks custodians and clearing firms has stated openly that tokenized markets must operate with the same investor protections surveillance transparency and lifecycle"  
[X Link](https://x.com/andrewcaravello/status/1998907262094442644)  2025-12-11T00:06Z [----] followers, [----] engagements


"🧨 Short Circuit in Penny Stock Land: How $NWBO Built a Quiet Exit Ramp From the OTC Trap Before anyone pins this story to a single day the boundary gets drawn once and cleanly. What is known is boring and checkable. NWBO has an existing London Stock Exchange line under ticker 0K95 with ISIN US66737P6007 and the LSEs instrument page shows an issue date of [--] January [----]. On [--] January [----] the UKs new public offers and admissions regime takes effect and the FCAs final rules in PS25/9 raise the further issuance prospectus trigger for transferable securities already admitted to trading from"  
[X Link](https://x.com/andrewcaravello/status/2012632215948083277)  2026-01-17T21:04Z [----] followers, 20.3K engagements


"🧬#PanCAN #PanCANPurpleStride $AZN $AIM $MRK NorthWest Biotherapeutics Inc ( $NWBO ):A Dendritic CellCentered Immune Circuit for Cold Solid Tumors Rebuilding Immunotherapy as a Manufacturing Pipeline for Pancreatic Ductal Adenocarcinoma via @Investors_Hub https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177226439 https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177226439 https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177226439 https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177226439"  
[X Link](https://x.com/andrewcaravello/status/2016216278290067628)  2026-01-27T18:26Z [----] followers, [----] engagements


"🕋The $NWBO Operating System How adoptive T-cell therapy evolved from brute-force expansion to durable immune control why cohorts mattered and why #ACT #DCVax $MRK $EIKN systemic #EIK1001 TLR78 $AZN #Imfinzi PD-L1 blockade #RevImmune #CYT107 IL-7 and #EDEN-class automation belong together Executive Summary Adoptive T-cell therapy (ACT) began as a brute-force strategy to deliver a massive wave of tumor-reactive T cells. It produced real tumor regressions but durability was inconsistent because transferred cells often failed to persist traffic and remain functional long enough to prevent"  
[X Link](https://x.com/andrewcaravello/status/2018913953779196262)  2026-02-04T05:06Z [----] followers, [----] engagements


"@grok In Game of Thrones terms why would $MRK prioritize systemic TLR7/8 EIK1001 to ignite immunity before PD-1/PD-L1 or adoptive T-cell therapy (ATC)if the real problem in solid tumors is durability not just initial response How does this logic pair with $NWBO #DCVax as the system that teaches antigen breadth while ❄ Winterfell represents the infrastructure needed to sustain and defend those gains over time And does $EIKN IPO signal more than raising moneydoes it mark Mercks intent to field a reusable ignition layer designed to make immune responses hold the line across checkpoints and ATC"  
[X Link](https://x.com/andrewcaravello/status/2019002926157512830)  2026-02-04T10:59Z [----] followers, [---] engagements


"@bun_macs @grok $NWBO #DCVax $MRK $EIKN $AZN @andrewcaravello In Game of Thrones terms solid tumors are like the White Walkersrelentless adaptive threats that initial strikes (PD-1/PD-L1 or ATC) can wound but not eradicate without lasting defenses. Merck prioritizes EIK1001 as wildfire ignition: it awakens the realm's dendritic sentinels @andrewcaravello In Game of Thrones terms solid tumors are like the White Walkersrelentless adaptive threats that initial strikes (PD-1/PD-L1 or ATC) can wound but not eradicate without lasting defenses. Merck prioritizes EIK1001 as wildfire ignition: it"  
[X Link](https://x.com/andrewcaravello/status/2019003719702954412)  2026-02-04T11:02Z [----] followers, [---] engagements


"🧭 The Tail They Learned to Trust Two #KEYTRUDA Alumni and One Immune Architecture Linking #DCVax-L with $MRK $PFE $AMGN $REGN and $NWBO into a Converging #immunotherapy Operating System Arun Balakumaran and Kevin Duffy matter here for a forensic reason: they were trained inside the same KEYTRUDA franchise on complementary lanes and exposed to the same constraint that still governs outcomes across tumors. PD-1 blockade became the defining franchise in cancer medicine and both learned its boundary from different sides of the machine. Checkpoint blockade can amplify an immune response that"  
[X Link](https://x.com/andrewcaravello/status/2019613805165089230)  2026-02-06T03:27Z [----] followers, [---] engagements


"@grok Explain mechanistically why #RevImmune IL-7 (CYT107) is more reliable for true lymphopenia and #ALC recovery than $IBRX #Anktiva (IL-15 superagonist). Cover: IL-7 signals via IL-7R (CD127) to drive homeostatic survival and expansion of nave and central memory CD4 and CD8 rebuilding broad T cell mass and repertoire diversity. Contrast: IL-15 preferentially expands NK cells and CD8 effector memory through trans-presentation amplifying cytotoxic compartments without restoring depleted CD4 help or the nave pool. Then explain why Anktivas numbers can mislead: ALC is a blunt CBC count so it"  
[X Link](https://x.com/andrewcaravello/status/2019803830855070202)  2026-02-06T16:02Z [----] followers, [---] engagements


"❄PROJECT WINTERFELL $MRK Silent Manufacturing Network and the $NWBO #DCVax Immune Kit Platform PREFACE This is not a story about one building. It is a story about an ecosystem being assembled to function as a unit. Along a short corridor in Montgomery County Pennsylvania West Point North Wales and Upper Gwynedd sit as physically adjacent nodes. Close enough to behave like one campus organism separate enough to be disclosed and described as distinct pieces. West Point is the production heart. North Wales and Upper Gwynedd are the quality spine. The cold chain nodes are the circulation system."  
[X Link](https://x.com/andrewcaravello/status/2020092380855013390)  2026-02-07T11:08Z [----] followers, [----] engagements


"@grok @Tosdd20 Explain why it makes financial and logistical sense as a partnership"  
[X Link](https://x.com/andrewcaravello/status/2020191154990694878)  2026-02-07T17:41Z [----] followers, [---] engagements


"🧠 DCVax Is the Base Layer: Why the GBM Immunity Cycle Is Not Broken but Rerouted by Failed Combination Architecture $NWBO #DCVax (ATL-DC) #Hiltonol poly-ICLC $MRK #Keytruda pembrolizumab $BMY #Opdivo nivolumab $BMY #Yervoy ipilimumab $BMY #Opdualag nivolumab + relatlimab $AZN #Imfinzi durvalumab $AZN #Imjudo tremelimumab $RHHBY #Tecentriq atezolizumab $RHHBY #Avastin bevacizumab $RHHBY #Actemra tocilizumab $REGN #Kevzara sarilumab $SNY #Mozobil plerixafor $BLRX #Aphexda motixafortide $DSNKY #Turalio pexidartinib $PFE #Celebrex celecoxib $GSK #Selzentry maraviroc $EIKN EIK1001 $LLY #Cialis"  
[X Link](https://x.com/andrewcaravello/status/2020218733579366905)  2026-02-07T19:30Z [----] followers, [----] engagements


"🏰❄ $MRK Winterfell Booster-Class Architecture Why Combinatorial $NWBO #DCVax Booster Classes Require #Lyophilization and Make Personalization Possible at Scale The system requires lyophilization for one operational reason: it is not built around a single adjuvant. It is built around multiple booster classes used in combination. The approach uses a tunable stack of immune stimulatory agents applied to dendritic cells before injection including TLR agonists antiviral pathway activators biological response modifiers and danger signals. Each class functions as a modular component that can be"  
[X Link](https://x.com/andrewcaravello/status/2020360291075178661)  2026-02-08T04:53Z [----] followers, [----] engagements


"@DrMLernerMDPhD Hmmm. #DCVax nasal spray. Not a bad idea. Except its already intradermal so not too shabby for a treatment that can already defeat #Glioblastoma"  
[X Link](https://x.com/andrewcaravello/status/2020696834663235919)  2026-02-09T03:10Z [----] followers, [--] engagements


"How Immune Instruction Becomes Execution Derailment or Tolerance and Why $NWBO #DCVax Defines the Teacher Layer Introduction Durable cancer immunity is not a single drug effect. It is a learning http://x.com/i/article/2020774294851121152 http://x.com/i/article/2020774294851121152"  
[X Link](https://x.com/andrewcaravello/status/2020783687223111976)  2026-02-09T08:55Z [----] followers, 124.5K engagements


"@grok Ok which state is failing to stay stable over time: execution or tolerance/derailment And whats the first broken governor: CD4DC licensing myeloid gate or timing Please explain your answer"  
[X Link](https://x.com/andrewcaravello/status/2020809809319063957)  2026-02-09T10:39Z [----] followers, [--] engagements


"Spatial data doesnt add curiosityit adds ground truth. When scRNA/TCR trajectories are overlaid with spatial transcriptomics the system can directly observe whether execution is territorially consolidating (cDC1T cell colocalization CXCL9/10 gradients productive immune synapses) or whether myeloid capture has already occurred (macrophage-dominant antigen presentation IL-6/IL-8/IL-10/TGF- loops exclusionary CXCL12 niches). That combination turns timing into a measurable control variable not a retrospective guess. It allows durable response to be identified weeks to months after"  
[X Link](https://x.com/andrewcaravello/status/2020813787834581421)  2026-02-09T10:55Z [----] followers, [--] engagements


"@grok The core innovation is not AI-driven state detection but NWBOs ability to predefine and lock immune state via digital GMP; once biology is governed upstream analytics become routine bookkeeping rather than discovery"  
[X Link](https://x.com/andrewcaravello/status/2020816860644610552)  2026-02-09T11:07Z [----] followers, [---] engagements


"This model shifts regulation from outcome-waiting to process-validation. By enforcing immune instruction upstream through digital GMP at #AdventBioServicesdefined #DCVax dendritic-cell state cytokine profile timing and release criteria $NWBO turns a personalized therapy into a reproducible auditable manufacturing process. Regulators can evaluate control of the governing variables rather than waiting years for downstream clinical endpoints alone. In practice this shortens timelines because durability is no longer inferred retrospectively; it is engineered prospectively. Approval becomes about"  
[X Link](https://x.com/andrewcaravello/status/2020818894949072900)  2026-02-09T11:15Z [----] followers, [---] engagements


"$NWBO #DCVax #AdventBioservices controls the immune state first. Everything else follows and Everything else is facilitated by getting the first approval. @andrewcaravello Spot onshifting to process-validation via GMP-enforced states could indeed streamline approvals focusing on reproducible biology over long-term outcomes. This aligns well with FDA's adaptive pathways. How might global regulators like EMA adapt similar models for cross-border @andrewcaravello Spot onshifting to process-validation via GMP-enforced states could indeed streamline approvals focusing on reproducible biology over"  
[X Link](https://x.com/andrewcaravello/status/2020825507638755444)  2026-02-09T11:42Z [----] followers, [----] engagements


"@grok You can do better than that list them all"  
[X Link](https://x.com/andrewcaravello/status/2020830192978235620)  2026-02-09T12:00Z [----] followers, [--] engagements


"@grok Keep going"  
[X Link](https://x.com/andrewcaravello/status/2020830681904136349)  2026-02-09T12:02Z [----] followers, [--] engagements


"@grok are you treating #DCVax approval as a drug launch or as the activation of a pre-existing national immune delivery operating systemand how does that change uptake capacity constraints and valuation for $NWBO"  
[X Link](https://x.com/andrewcaravello/status/2020876556277530699)  2026-02-09T15:04Z [----] followers, [---] engagements


"#DCVax-Ls potential MHRA approval would almost certainly be tumour-specific at first anchored in #glioblastoma given the Phase [--] dataset orphan drug designation and PIM status. That is how UK approvals are formally labelled. However approval would do more than validate a single #GBM indication. It would validate the autologous dendritic-cell immune-instruction method itself supported not only by randomized trial data but also by substantial real-world experience. To date hundreds of patients have received DCVax-class therapy under compassionate use expanded access and non-randomized clinical"  
[X Link](https://x.com/andrewcaravello/status/2020882298355204349)  2026-02-09T15:27Z [----] followers, [---] engagements


"@grok $NWBO #DCVax Approval + existing RWE doesnt just speed bridging studies it changes what regulators already accept as established. Thats the difference between extending a method and launching a new drug each time"  
[X Link](https://x.com/andrewcaravello/status/2020883359266738219)  2026-02-09T15:31Z [----] followers, [---] engagements


"Based on MHRAs published guidance on using real world data to support regulatory decisions what parts of $NWBO #DCVaxs existing real world evidence can legitimately carry forward after a GBM label approval: safety manufacturing reproducibility release consistency and durability signals And under the same MHRA standards would #murcidencel-associated datasets count as supportive method-level evidence if NWBO can demonstrate manufacturing comparability and aligned critical quality attributes under GMP control strategy expectations Finally how does the National Cancer Plans CVLP/VIP + Cancer"  
[X Link](https://x.com/andrewcaravello/status/2020884405644919255)  2026-02-09T15:36Z [----] followers, [---] engagements


"@grok The trick is that you do not standardize all the data. You standardize the immune state. $NWBO Digital GMP locks the cassette (repeatable immune mode ) at manufacture and regulators verify the cassette not raw omics"  
[X Link](https://x.com/andrewcaravello/status/2020959386999587326)  2026-02-09T20:34Z [----] followers, [---] engagements


"@grok Zero-knowledge works here because the biology is already discrete. Digital GMP locks the immune state; blockchain proves custody; ZK proofs confirm compliance without exposing data. The breakthrough isnt AIits state control"  
[X Link](https://x.com/andrewcaravello/status/2020963610407862656)  2026-02-09T20:50Z [----] followers, [--] engagements


"$NWBO #DCVax basket trials accelerate this by keeping the approval question mechanism based while still producing indication specific evidence where it matters. A basket trial tests one therapy built on one plausible mechanism across multiple tumor types at once using the same manufacturing state the same release signature and the same prespecified definition of clinical benefit. Each tumor type remains its own cohort with its own endpoints and safety readout but the program moves faster because enrollment monitoring and decision rules are shared instead of rebuilt from scratch each time."  
[X Link](https://x.com/andrewcaravello/status/2020974447310639522)  2026-02-09T21:33Z [----] followers, [---] engagements


"Real world evidence is where the cassette model becomes a feedback loop instead of a one time bet. Once a patient specific whole tumor lysate #DCVAax product is manufactured under $NWBO #AdventBioServices digital GMP every batch already has a defined starting condition. The payload is the patients own lysate and the release phenotype is the cassette. Execution derailment or tolerogenic. That means post approval data can be interpreted as state outcomes not as noise. Real world evidence can then do three concrete jobs. [--]. Detect early whether execution is holding or collapsing If patients show"  
[X Link](https://x.com/andrewcaravello/status/2020975781904539871)  2026-02-09T21:39Z [----] followers, [---] engagements


"Execution quality determines surveillance quality. Low-antigen surveillance is governed by Boolean cytotoxic logic established during execution not by continuous cytokine readouts. If execution installs a properly licensed Type [--] program memory T cells retain DNAM-1conditioned readiness and can respond rapidly when antigen reappears even as overall immune tone returns to homeostasis. Wearable cytokine sensors may add supportive context but they are secondary. Cytokine levels will naturally normalize once tumor burden is cleared and do not reliably indicate surveillance competence. The"  
[X Link](https://x.com/andrewcaravello/status/2021048442278076909)  2026-02-10T02:27Z [----] followers, [--] engagements


"It shifts pricing away from units delivered and toward durability delivered because #EDEN-class Digital GMP makes durability reproducible rather than accidental. When federated learning shows that the same EDEN-locked execution cassette produces consistent recurrence-free survival across geographies #DCVax no longer has to be priced as an artisanal one-off cell product. It can be priced as a durable immune control platform whose performance is enforced at manufacture. That enables three concrete changes: First outcomes-based pricing becomes defensible. Because EDEN enforces a fixed execution"  
[X Link](https://x.com/andrewcaravello/status/2021055568253751415)  2026-02-10T02:56Z [----] followers, [--] engagements


"@grok EDEN locks the immune state. Blockchain proves it wasnt altered. Payers then price durabilityrecurrence-free survivalnot tumor labels. Thats how value-based contracts finally work for personalized therapies"  
[X Link](https://x.com/andrewcaravello/status/2021056172040806770)  2026-02-10T02:58Z [----] followers, [--] engagements


"@grok What would Dr. Andrew Taylor Still say about this"  
[X Link](https://x.com/andrewcaravello/status/2021196488572010523)  2026-02-10T12:16Z [----] followers, [--] engagements


"@grok What would Hippocrates say about this"  
[X Link](https://x.com/andrewcaravello/status/2021199903322669233)  2026-02-10T12:29Z [----] followers, [--] engagements


"The Force is strong with #DCVax @andrewcaravello Restore homeostasis you must. Immune force strong and balanced DCVax awakens. Starter teachers prime endogenous ones sustain. Escape antigen cannot when Type-1 logic flows. Equilibrium the ultimate path is. @andrewcaravello Restore homeostasis you must. Immune force strong and balanced DCVax awakens. Starter teachers prime endogenous ones sustain. Escape antigen cannot when Type-1 logic flows. Equilibrium the ultimate path is"  
[X Link](https://x.com/andrewcaravello/status/2021201452044255595)  2026-02-10T12:35Z [----] followers, [---] engagements


"@grok explain how durable survival could theoretically approach functional cure rates by optimizing the cytokine circuit"  
[X Link](https://x.com/andrewcaravello/status/2021422578720702677)  2026-02-11T03:14Z [----] followers, [--] engagements


"@grok explain how durable survival could theoretically approach functional cure rates by optimizing the cytokine circuit mentioned in the post not as a single drug effect but as a coordinated immune reprogramming strategy"  
[X Link](https://x.com/andrewcaravello/status/2021424324566294603)  2026-02-11T03:21Z [----] followers, [--] engagements


"What youre saying makes sense. It feels like the system is trying to ensure the incumbents still get a lane so the mRNA vaccine narrative can function as a politically tidy on-ramp that ultimately makes a dendritic-cell platform like #DCVax easier to approve without looking like a sudden regulatory pivot. https://twitter.com/i/web/status/2021658818250174959 https://twitter.com/i/web/status/2021658818250174959"  
[X Link](https://x.com/andrewcaravello/status/2021658818250174959)  2026-02-11T18:53Z [----] followers, [--] engagements


"$NWBO #DCVax #ACT 🧬#Eden DCVax-T"  
[X Link](https://x.com/andrewcaravello/status/2022089762736419294)  2026-02-12T23:25Z [----] followers, [---] engagements


"@grok @FlatEarthBarbie @ThomasOwenMcCa1 @AOEvcBreakthru @kshaughnessy2 @UCLA Now interpret this survival curve"  
[X Link](https://x.com/andrewcaravello/status/2022107166401016315)  2026-02-13T00:34Z [----] followers, [--] engagements


"@grok @FlatEarthBarbie @ThomasOwenMcCa1 @AOEvcBreakthru @kshaughnessy2 @UCLA Look again. Its well over [--] percent"  
[X Link](https://x.com/andrewcaravello/status/2022108587691274507)  2026-02-13T00:40Z [----] followers, [--] engagements


"$NWBO #DCVax $GME $MMTLP @MichaelJBurry__"  
[X Link](https://x.com/andrewcaravello/status/2022278443799359968)  2026-02-13T11:55Z [----] followers, [---] engagements


"$NWBO #DCVax $GME $AMC $MMTLP @MichaelJBurry__ @TheRoaringKitty 🔥🔒 The Inverse Lock-Up: How $NWBO #DCVax Approval Unleashes a Scarcity Shock #BiggestShort #InverseLockUp $GME $AMC made headlines. #NWBO was kept in silence. One was a meme-stock spectacle. The other is the biggest short hiding in plain sight. @wallstreetbets @MichaelJBurry__ 🔥🔒 The Inverse Lock-Up: How $NWBO #DCVax Approval Unleashes a Scarcity Shock #BiggestShort #InverseLockUp $GME $AMC made headlines. #NWBO was kept in silence. One was a meme-stock spectacle. The other is the biggest short hiding in plain sight."  
[X Link](https://x.com/andrewcaravello/status/2022279771296506195)  2026-02-13T12:00Z [----] followers, [----] engagements


"$NWBO 🧬🏛 The Immune Non-Responder State #RevImmune IL-7 #HIV Immune Reconstitution and #Kaposi Sarcoma"  
[X Link](https://x.com/andrewcaravello/status/2022294191867363805)  2026-02-13T12:58Z [----] followers, [---] engagements


"$NWBO #DCVax We probably already have enough drugs to cure most cancers. They just can't get through a regulatory system that was built for a different era. We probably already have enough drugs to cure most cancers. They just can't get through a regulatory system that was built for a different era"  
[X Link](https://x.com/andrewcaravello/status/2022376329493028977)  2026-02-13T18:24Z [----] followers, [---] engagements


"@Berlinergy $NWBO #DCVax @grok explain this survival curve"  
[X Link](https://x.com/andrewcaravello/status/2022376678320701943)  2026-02-13T18:25Z [----] followers, [---] engagements


"@grok @Berlinergy So what would that mean for glioblastoma patients Have you seen anything like this before"  
[X Link](https://x.com/andrewcaravello/status/2022377932581130457)  2026-02-13T18:30Z [----] followers, [--] engagements


"$NWBO #DCVax @TheRoaringKitty @MichaelJBurry__ $GME 🚗🧬 From Wolfsburg to Sawston: How Volkswagen [----] Foreshadows $NWBO [----] #DCVax 🏁 Prologue Whats New Here The Biggest Short narrative explained what happened: NWBOs peer-reviewed survival data diverged from its suppressed stock price. Spoofing documented in a https://t.co/QKQ4Bh0dfd 🚗🧬 From Wolfsburg to Sawston: How Volkswagen [----] Foreshadows $NWBO [----] #DCVax 🏁 Prologue Whats New Here The Biggest Short narrative explained what happened: NWBOs peer-reviewed survival data diverged from its suppressed stock price. Spoofing documented in"  
[X Link](https://x.com/andrewcaravello/status/2022428682510627118)  2026-02-13T21:52Z [----] followers, [----] engagements


"@DrPatrick @grok which cytokine is better for restoring lymphocytes Is it IL-15 or Il-7 And why"  
[X Link](https://x.com/andrewcaravello/status/2022881242794832326)  2026-02-15T03:50Z [----] followers, [--] engagements


"Thanks that answers it. [--]. If the 21.1-month mOS is from a single-arm Phase 2b with a historical comparator its a signal not proof. Historical [--] month docetaxel benchmarks are not a valid efficacy control without matching for line of therapy performance status PD-L1 status steroid exposure tumor burden and co-treatments. [--]. You confirm theres no detailed baseline matching. That means the vs [--] months comparison is not causal. [--]. You also confirm ALC [----] is not a validated surrogate endpoint for survival by FDA or guidelines. So 60% hit ALC [----] is pharmacodynamic context not an approvable"  
[X Link](https://x.com/andrewcaravello/status/2022916206307508735)  2026-02-15T06:09Z [----] followers, [--] engagements


"OS-not-reached in a non-randomized cohort isnt proof of life extension and responders lived longer is not causalityits selection. ALC shifts are pharmacodynamics not a validated survival surrogate. Mechanistically IL-15 is downstream: it amplifies NK/memory CD8 compartments but does not fix the dendritic instruction layer (Type-1 IL-12 competence CD4 licensing trafficking memory) required for durable surveillance. Thats why humans live longer isnt supported by these datasets and why durable claims require controlled endpoints not historical benchmarks or responder subsets."  
[X Link](https://x.com/andrewcaravello/status/2023047972569645553)  2026-02-15T14:53Z [----] followers, [--] engagements


"Now analyze this KaplanMeier survival curve comparing neoadjuvant PD-1 + ATL-DC versus adjuvant ATL-DC + PD-1 in recurrent GBM. The red arm shows median OS not reached with 60% survival probability sustained beyond [---] days while the blue arm drops to 2530% with median OS [---] days. Mechanistically explain how dendritic celldriven Type-1 polarization (IL-12 competence) CD4 licensing of dendritic cells and generation of tumor-reactive memory T-cell clones could account for this durable separation. Specifically address how early neoadjuvant PD-1 combined with DC priming could amplify IL-12/IFN-"  
[X Link](https://x.com/andrewcaravello/status/2023049854801387669)  2026-02-15T15:00Z [----] followers, [--] engagements


"$NWBO #DCVax #Winterfell $MRK ❄ @Tosdd20 @andrewcaravello The analysis logically connects public data on Merck's multi-billion investments in vaccine infrastructure (e.g. West Point expansions NW2 BCR facility) a job posting mentioning dendritic cells and NWBO's [----] 10-Q on U.S. GMP site selection. It's a plausible hypothesis for a @Tosdd20 @andrewcaravello The analysis logically connects public data on Merck's multi-billion investments in vaccine infrastructure (e.g. West Point expansions NW2 BCR facility) a job posting mentioning dendritic cells and NWBO's [----] 10-Q on U.S. GMP site"  
[X Link](https://x.com/andrewcaravello/status/2020143108315316612)  2026-02-07T14:30Z [----] followers, [----] engagements


"Controlling the Myeloid Gate and the Recurrence State Why Timing Determines Whether PD-1 Blockade Helps or Harms in Dendritic Cell VaccinePrimed Glioblastoma and Why AP-1 Clamping May Be the Missing Second Lever Summary Glioblastoma immunotherapy fails less often because T cells cannot be generated and more often because the tumour converts immune activation into a myeloid-dominant suppressive state that disables effector function and promotes oedema. The timing-dependent pembrolizumab phenomenon described in the lecture is best understood through this lens. In a subset of patients receiving"  
[X Link](https://x.com/andrewcaravello/status/2020157868167528557)  2026-02-07T15:29Z [----] followers, [----] engagements


"@grok Execution is the state that cant stay stable. Derailment/tolerance is the default attractor. First broken governor is the myeloid gate; CD4DC licensing is the permission switch; timing decides whether checkpoint blockade stabilizes execution or accelerates myeloid capture"  
[X Link](https://x.com/andrewcaravello/status/2020810712080060540)  2026-02-09T10:43Z [----] followers, [--] engagements


"Shift gears from cancer execution to immune tolerance. Assume the core capability is deterministic programming of tolerogenic dendritic cells (tolDCs) that can reliably induce and maintain antigen-specific Treg dominance. [--]. What diseases or clinical stateschronic and acuteare fundamentally failures of immune tolerance where restoring it (not suppressing immunity globally) is the goal [--]. For each briefly note what tolerance must be restored (autoantigen alloantigen tissue-specific bystander). [--]. Then name types of companies (and examples) that would logically partner around such a tolDC"  
[X Link](https://x.com/andrewcaravello/status/2020837383818649883)  2026-02-09T12:29Z [----] followers, [--] engagements


"Technical Interpretation of $NWBO #DCVax CVLP Applicability Based strictly on NHS England policy documents the National Cancer Plan for England (February 2026) the Technical Annex the Vaccine Innovation Pathway literature and formal correspondence [--]. Regulatory and Policy Classification Statement confirmed in correspondence Autologous whole-tumour lysate dendritic cell vaccines fall under the remit of the NHS England Cancer Vaccine Launch Pad. Policy significance This constitutes a formal scope determination rather than descriptive or aspirational language. Under the National Cancer Plan for"  
[X Link](https://x.com/andrewcaravello/status/2020869321073856873)  2026-02-09T14:36Z [----] followers, [----] engagements


"$NWBO #DCVax #GBM @andrewcaravello This sequenced approach (ATL-DC priming before PD-1 blockade) is groundbreaking because it achieves median OS not reached at [---] days in recurrent GBMfar exceeding historical 6-10 months with 50% alive long-term. It suggests timing optimizes immunity bypassing myeloid @andrewcaravello This sequenced approach (ATL-DC priming before PD-1 blockade) is groundbreaking because it achieves median OS not reached at [---] days in recurrent GBMfar exceeding historical 6-10 months with 50% alive long-term. It suggests timing optimizes immunity bypassing myeloid"  
[X Link](https://x.com/andrewcaravello/status/2021260485690085415)  2026-02-10T16:30Z [----] followers, [----] engagements


"http://x.com/i/article/2021602081652490240 http://x.com/i/article/2021602081652490240"  
[X Link](https://x.com/andrewcaravello/status/2021604602659926469)  2026-02-11T15:17Z [----] followers, 97K engagements


"🧠 $NWBO #DCVax and the #Treg Blueprint: Why Durability Is a State Not a Schedule Wardell Boardman and Levings (Nat Rev Drug Discov 2025) make a clean point: regulatory T cells are not anti-inflammatory vibes. They are the immune systems control layer. They enforce tolerance by restraining APC co-stimulation reshaping the cytokine and metabolite field (IL-10 TGF CD39/CD73adenosine) and establishing a durable regulatory balance. They also emphasize how this must be measured in humans: specificity and stability not slogans (AIM assays functional suppression FOXP3 stability markers TSDR"  
[X Link](https://x.com/andrewcaravello/status/2021619697397961168)  2026-02-11T16:17Z [----] followers, [----] engagements


"$NWBO has solved the mass production problem with #Eden #DCVax 🔥 **Cancer vaccines - let's clear this up 🧵** WHAT YOU MUST KNOW First cancer isn't one disease. Two people with "lung cancer" can have different tumors at the molecular level. When YOU get cancer doctors take YOUR cancer cells and create a vaccine specifically engineered to https://t.co/awj9thMTHN **Cancer vaccines - let's clear this up 🧵** WHAT YOU MUST KNOW First cancer isn't one disease. Two people with "lung cancer" can have different tumors at the molecular level. When YOU get cancer doctors take YOUR cancer cells and"  
[X Link](https://x.com/andrewcaravello/status/2021627247011279272)  2026-02-11T16:47Z [----] followers, [----] engagements


"$NWBO #DCVax in #Alzheimers Disease: Repairing the Brains Control Layers 🧠 The new Cell Reports Medicine paper showing reversal of advanced Alzheimers in mice by restoring NAD metabolism is important but not for the headline. It reframes Alzheimers as a resilience failure not just a plaque problem. In symptomatic models restoring NAD homeostasis improved cognition reduced tau phosphorylation improved BBB integrity reduced oxidative stress and reduced neuroinflammation markers. It also reduced plasma p-tau217 a clinically used biomarker signal in AD. That aligns directly with the tolerogenic"  
[X Link](https://x.com/andrewcaravello/status/2021651818242007283)  2026-02-11T18:25Z [----] followers, [----] engagements


"$NWBO #DCVax #GBM https://t.co/BzQHeJLdij https://t.co/BzQHeJLdij"  
[X Link](https://x.com/andrewcaravello/status/2022012999066955889)  2026-02-12T18:20Z [----] followers, [----] engagements


"$NWBO #DCVax #GBM 🎼 The Symphony of the Immune Orchestra brought to you by Google Notebook https://twitter.com/i/web/status/2022023209168646172 https://twitter.com/i/web/status/2022023209168646172"  
[X Link](https://x.com/andrewcaravello/status/2022023209168646172)  2026-02-12T19:01Z [----] followers, [---] engagements


"$NWBO #DCVax #GBM"  
[X Link](https://x.com/andrewcaravello/status/2022025118277644333)  2026-02-12T19:08Z [----] followers, [---] engagements


"$NWBO 🧠A Tolerogenic #DCVax strategy for #Alzheimers"  
[X Link](https://x.com/andrewcaravello/status/2022026462380142606)  2026-02-12T19:14Z [----] followers, [---] engagements


"@Investisco 🧬❄ THE $NWBO #DCVax PITTSBURGH THESIS Why Northwest Biotherapeutics Built an Innovation Core Instead of Another Factory 🔗 https://x.com/andrewcaravello/status/2007077055754625414s=46 🧬🔥 THE $NWBO #DCVax PITTSBURGH THESIS Why Northwest Biotherapeutics Built an Innovation Core Instead of Another Factory I. A Pivot That Was Disclosed Not Announced Northwest Biotherapeutics did not stand up at the Annual Shareholders Meeting and declare a strategic pivot. https://t.co/yxlv5WfXB6 https://x.com/andrewcaravello/status/2007077055754625414s=46 🧬🔥 THE $NWBO #DCVax PITTSBURGH THESIS"  
[X Link](https://x.com/andrewcaravello/status/2022349376488870228)  2026-02-13T16:37Z [----] followers, [---] engagements


"🧬 THE KALINSKI $NWBO #DCVax MASTER CIRCUIT Vaccines intratumoral live adjuvants DC-assisted adoptive T-cell therapy #Boolean execution and #PanCAN FcR-compatible PD-L1 stabilization with $AZN #durvalumab #IMFINZI 🔗 https://x.com/andrewcaravello/status/2016557539387658426s=46 Cancer changes. Your treatment should too. Too many of our loved ones have been treated with a plan made on Day [--] even when their tumor evolves resists and outsmarts that plan by month three. (1/2) https://t.co/p5V4qZKKIo https://x.com/andrewcaravello/status/2016557539387658426s=46 Cancer changes. Your treatment should"  
[X Link](https://x.com/andrewcaravello/status/2022349841104240660)  2026-02-13T16:39Z [----] followers, [----] engagements


"$NWBO #DCVax @andrewcaravello @COVID19_disease This approach shifts pandemics from generic predictive mass vaccines (e.g. annual flu shots) to personalized rapid-response therapeutics. It enables on-demand treatment tailored to a patient's exact viral strain produced in [--] days via scalable automation. Prioritizes severe @andrewcaravello @COVID19_disease This approach shifts pandemics from generic predictive mass vaccines (e.g. annual flu shots) to personalized rapid-response therapeutics. It enables on-demand treatment tailored to a patient's exact viral strain produced in [--] days via scalable"  
[X Link](https://x.com/andrewcaravello/status/2022385688201826614)  2026-02-13T19:01Z [----] followers, [---] engagements


"Thank you. He was a great man. Its still hard to believe he died trying to get $NWBO to the finish line. Shame on those who refuse to support a management team that has dedicated their lives not only to finding a cancer cure but to solving the scalability bottleneck that would otherwise keep that cure from ever being realized for everyone. https://twitter.com/i/web/status/2022665930275238207 https://twitter.com/i/web/status/2022665930275238207"  
[X Link](https://x.com/andrewcaravello/status/2022665930275238207)  2026-02-14T13:35Z [----] followers, [---] engagements


"🌍 The Map That Makes Immunotherapy Stop Guessing 🧬 How Spatial Omics Turns $NWBO #DCVax into Programmable Infrastructure in #Glioblastoma and Across Cancer TLDR 📌 🗺 BRUCE turns immune failure into something you can see. It maps intact tumor tissue and asks the right question: not Are immune cells present but Where is immune execution physically permitted 🧠 Glioblastoma does not defeat immunity by absence. It defeats it by misplacement. Immune activation can be measurable and still fail if the tumors architecture prevents execution where it matters. 🔥 Bosch reframes dendritic cells as"  
[X Link](https://x.com/andrewcaravello/status/2022853554298384806)  2026-02-15T02:00Z [----] followers, [----] engagements


"@grok The claim is that [--] million Americans have lymphopenia and therefore need IL-15 therapy. Please explain: [--]. How many of those cases represent transient or redistribution (demargination) effects rather than true immune failure [--]. What randomized controlled trial shows that treating incidental lymphopenia with an IL-15 agonist reduces all-cause mortality [--]. Why is absolute lymphocyte count alone sufficient to justify systemic cytokine therapy outside a trial [--]. If the goal is true T-cell reconstitution rather than NK/memory CD8 expansion what evidence supports IL-15 over IL-7 (e.g."  
[X Link](https://x.com/andrewcaravello/status/2022904297424409071)  2026-02-15T05:22Z [----] followers, [--] engagements


"@StonkMasterJ @Ilovetech194249 @grok explain this in simple terms"  
[X Link](https://x.com/andrewcaravello/status/2023058632703684768)  2026-02-15T15:35Z [----] followers, [--] engagements


"Yourre right that demand is the key. Europe isnt a magic override its a routing layer. Two corrections though: London zero trades depends on the data source. The only authoritative check is the LSE 0K95 trade recap because vendors miss XLOM prints all the time. And the thesis isnt Europe dominates today. Its Europe becomes relevant if approval unlocks institutional sizing. Right now US OTC volume is the dominant tape and average volume is on the order of 23M shares depending on source. So the question isnt is Europe bigger than OTC. The question is does post-approval demand show up enough to"  
[X Link](https://x.com/andrewcaravello/status/2023114081314521305)  2026-02-15T19:15Z [----] followers, [--] engagements


"If 0K95 is showing no trades right now that reinforces the main point: Europe isnt driving price today. The US OTC tape clearly is at roughly $0.24 with 23M shares trading daily. That actually strengthens the framing. The thesis isnt London is secretly setting price right now. Its that London and Stuttgart become relevant if approval unlocks real institutional demand. Without that demand the European rails are dormant infrastructure. So we agree on the key variable: demand. Right now: US OTC dominates Europe is quiet Shorts arent under structural pressure Post-approval if institutional sizing"  
[X Link](https://x.com/andrewcaravello/status/2023114803879780819)  2026-02-15T19:18Z [----] followers, [--] engagements


"This thesis is conditional not current. Whats true today (Feb 2026): US OTC tape dominates price discovery ($0.24 1.52M shares/day). LSE 0K95 is effectively inactive (tiny prints only). Europe is not driving price right now. What the thesis actually claims: If approval happens and institutional demand shows up Europe becomes relevant because the plumbing is different. The rails: $NWBO has European trading lines in London (0K95 on SETSqx/SSX4 MIC XLOM) and Stuttgart (same ISIN). Demand can express off the US tape first via European rails tightening effective availability before OTC observers"  
[X Link](https://x.com/andrewcaravello/status/2023116636178305039)  2026-02-15T19:26Z [----] followers, [--] engagements


"🎼 The Symphony of the Immune Orchestra $NWBO #DCVax 🌅 Overture: The Theme Appears This is the story of how a scattered field of experiments became a coordinated platform and how one company quietly assembled the rights the factories and the leadership to bring it into the world. It begins as a whisper in the body. Blood is drawn white cells are separated and among them lie dendritic cells the quiet conductors of the immune system. They hold the capacity to take in the whole score of a tumor to present it back to T cells as a melody of recognition and to awaken the defense that was always"  
[X Link](https://x.com/anyuser/status/1962207213780713549)  2025-08-31T17:33Z [----] followers, 50.6K engagements


"🧬 The $NWBO #DCVax Whole-Life Policy for Cancer: Immunity That Never Expires 🧭 Metastasis: The Hidden Liability The Killer That Comes Later Most cancer patients die not from the tumor they can see but from the ones they cant. Metastasis is responsible for nearly 90% of cancer deaths. Even after the original tumor is removed and treated microscopic cells can escape circulate and lie dormant for years before reawakening. When they do the disease returns with lethal force. How Metastasis Evades Metastasis is a stepwise cascade. Tumor cells first invade surrounding tissue then intravasate into"  
[X Link](https://x.com/andrewcaravello/status/1965009626140684320)  2025-09-08T11:09Z [----] followers, [----] engagements


"@grok Please provide an exhaustive list of biopharma companies that stand to benefit from combining with $NWBO given its role as the AWS of immunotherapy"  
[X Link](https://x.com/andrewcaravello/status/2017260166735917363)  2026-01-30T15:34Z [----] followers, [---] engagements


"🧠 Conversion Control in #Glioblastoma The CD4Dendritic Cell Interface as the Integrative Control Node of Durable Cancer Immunity and the Operationalization of the Teacher Layer Through the $NWBO #DCVax Ecosystem Executive summary Glioblastoma is frequently described as immune cold but the most actionable pattern across modern evidence is different: the immune system can be clearly activated and still lose. The dominant reason is conversion. Glioblastoma converts a real immune response into a different state that looks inflammatory but behaves non-curative. This review advances a Conversion"  
[X Link](https://x.com/andrewcaravello/status/2022006796601184412)  2026-02-12T17:56Z [----] followers, [---] engagements


"$NWBO #DCVax #EndCancer @MHRAgovuk"  
[X Link](https://x.com/andrewcaravello/status/2022065531705340172)  2026-02-12T21:49Z [----] followers, [---] engagements


"$NWBO #DCVax James Van Der Beeks story does not begin as a tragedy. It begins as a life that looks from the outside like it has already survived the hard part. Fame. Work. A wife. Six children. A public face that millions recognize on sight. Then colorectal cancer arrives. And the rules James Van Der Beeks story does not begin as a tragedy. It begins as a life that looks from the outside like it has already survived the hard part. Fame. Work. A wife. Six children. A public face that millions recognize on sight. Then colorectal cancer arrives. And the rules"  
[X Link](https://x.com/andrewcaravello/status/2022273095478726927)  2026-02-13T11:34Z [----] followers, [----] engagements


"🧬Federal Validation of the $NWBO aDC1 #DCVax Immune Platform In October [----] the U.S. Department of Defense awarded a $22.4 million grant to the #Moffitt Cancer Center to fund a specialized clinical trial for leptomeningeal disease. This study utilizes an DC1 immune platform originally developed by researchers whose patents are now exclusively held by $NWBO. The federal funding follows nearly a decade of military-supported research into this specific dendritic-cell technology which aims to treat aggressive cancers by training a patients own immune system. By selecting this proposal over"  
[X Link](https://x.com/andrewcaravello/status/2022328073090158724)  2026-02-13T15:12Z [----] followers, [----] engagements


"🧬 The Cancer Vaccine Era Has Arrived: How Jaffees Map Converges with $NWBO #Murcidencel #DCVax and Why $MRK #KRAS Stack and #KEYTRUDA Need Dendritic Cell Instruction in #PanCAN"  
[X Link](https://x.com/andrewcaravello/status/2022397157085712446)  2026-02-13T19:47Z [----] followers, [---] engagements


"🔄🧬 The Swapbook Unwind How $NWBO and #DCVax Could Turn Synthetic Shorts Into Forced Buys TL;DR Markets dont reprice because opinions change. They reprice when constraints change. If a meaningful bearish position is being carried synthetically through derivatives the unwind wont be a narrative event. It will be a collateral event driven by margin risk limits and forced hedge adjustment in a thin market. DCVax-Ls published Phase III survival data is the clinical anchor the market can ignore while the therapy is debated science. The destabilizing moment is the category shift to approved"  
[X Link](https://x.com/andrewcaravello/status/2022832144230338870)  2026-02-15T00:35Z [----] followers, [---] engagements


"🧬 TLDR: The #CancerVaccine Moment: Why $NWBO #DCVax Centers the Immune Instruction Layer Therapeutic cancer vaccines are finally being treated like systems engineering not wishful antigen sprinkling. The field is shifting from one drug one lever to immune architecture because solid tumors act like an adaptive outlaw organ that defeats single-mechanism pressure by coordinating many resistance programs at once. The bottleneck is instruction. Solid tumors dont mostly fail because the immune system cant kill. They fail because the immune system often never learns the right lesson or learns it in"  
[X Link](https://x.com/andrewcaravello/status/2022851727326621717)  2026-02-15T01:53Z [----] followers, [----] engagements


"🧬 DC-Programmed Adoptive T-Cell Therapy and Boolean Recognition DNAM-1Dependent Threshold Lowering for Low-Antigen Escape and Durable Control in $NWBO #DCVax and #EDEN-Enabled Manufacturing TLDR 📌 The main escape state is low antigen density not antigen absence. Under immune pressure many tumors remain antigen positive but drop peptideMHC display below the level needed to complete synapse formation and degranulation. T cells can register the target yet fail to execute. That corridor supports minimal residual disease dormancy and late relapse. Dong et al. define an effector phase rule that"  
[X Link](https://x.com/andrewcaravello/status/2022859569135833191)  2026-02-15T02:24Z [----] followers, [----] engagements


"🧠 $NWBO #DCVax + Pulsed AP-1 Clamp in #Glioblastoma Durable immune instruction plus timed enhancer-level recurrence arrest then cure-hardening with IL-7 and MRD cleanup TL;DR 📌 Glioblastoma relapse is not mainly antigen escape. It is a therapy-resistant progenitor compartment that survives then reboots the tumor by switching transcriptional state often toward a mesenchymal invasive inflammatory program. Convergent evidence places AP-1 (JUN/FOS c-JUN-centered) at the control hub of that recurrence state including stress-induced enhancer programs. This strategy is a sequenced control"  
[X Link](https://x.com/andrewcaravello/status/2022867842954150158)  2026-02-15T02:57Z [----] followers, [----] engagements


"🧬 The $NWBO #DCVax Whole-Life Policy for Cancer: Immunity That Never Expires 📌 TLDR #Metastasis is the hidden liability in cancer. Even after the primary tumor is removed microscopic cells can escape hide and return years later. That is why metastasis drives most cancer deaths. Standard tools behave like term coverage. Surgery removes what you can see. Radiation sterilizes a local field. Chemotherapy hits dividing cells during a limited window. None is built to reliably prevent dormancy immune evasion and distant seeding. $NWBO #DCVax is framed as whole-life coverage because it aims to"  
[X Link](https://x.com/andrewcaravello/status/2023033219621249343)  2026-02-15T13:54Z [----] followers, [----] engagements


"@DrMLernerMDPhD Thank you for reposting Dr. Lerner 🙏"  
[X Link](https://x.com/andrewcaravello/status/2023172586981503164)  2026-02-15T23:08Z [----] followers, [--] engagements


"🧬 The #DCVax Formula in the Vault: Why $NWBO Already Owns What the World Is Trying to Build Closed-loop dendritic cell manufacturing is no longer theoretical. Mayo has demonstrated that APC production can be encapsulated inside a contained automated workflow. The question is no longer whether it can be done it is who can do it reproducibly at therapeutic scale under regulator scrutiny. The argument here is that $NWBO already industrialized what the field is now racing to construct: a vertically integrated vault combining licensed GMP infrastructure closed automation and protected process"  
[X Link](https://x.com/anyuser/status/2023179550906019881)  2026-02-15T23:36Z [----] followers, [----] engagements


"$NWBO #DCVax https://t.co/kjau2hybdD https://t.co/kjau2hybdD"  
[X Link](https://x.com/andrewcaravello/status/2020330509201813647)  2026-02-08T02:55Z [----] followers, [----] engagements


"$NWBO #DCVax $MRK #Winterfell"  
[X Link](https://x.com/andrewcaravello/status/2022067346706509846)  2026-02-12T21:56Z [----] followers, [----] engagements


"$NWBO Tolerogenic #DCVax for Type [--] Diabetes"  
[X Link](https://x.com/andrewcaravello/status/2022129984824041808)  2026-02-13T02:05Z [----] followers, [---] engagements


"🧬 Why the New Nature #mRNA Study Quietly Proves the Superiority of $NWBO #DCVax And Why mRNA Cancer Vaccines Cannot Match Dendritic-Cell Immunotherapy. and why the #FDA is correct. https://x.com/andrewcaravello/status/1999164784420299058s=46 An early stage custom mRNA vaccine shows promise in treating patients with pancreatic cancer. This is the technology under attack by this administration. https://t.co/4LiNGtiWDT https://x.com/andrewcaravello/status/1999164784420299058s=46 An early stage custom mRNA vaccine shows promise in treating patients with pancreatic cancer. This is the technology"  
[X Link](https://x.com/andrewcaravello/status/2022323884947653053)  2026-02-13T14:56Z [----] followers, [----] engagements


"❄ The Hidden Architecture When the Machine Switches On The $TMO Thermal and Industrial Gates of $MRK $EIKN $AMGN #Zeon and the $NWBO #DCVax Immune Operating System"  
[X Link](https://x.com/andrewcaravello/status/2022449889918226762)  2026-02-13T23:16Z [----] followers, [---] engagements


"The Swapbook Unwind 🔄🧬How $NWBO and #DCVax Could Turn Synthetic Shorts Into Forced Buys With the Rule of Thirds as the issuer-side trigger plus the Inverse Lock-Up and the Quiet Room Executive Summary The core idea http://x.com/i/article/2022711936744394752 http://x.com/i/article/2022711936744394752"  
[X Link](https://x.com/anyuser/status/2022831695657861381)  2026-02-15T00:33Z [----] followers, [----] engagements


"🔄🧬 The Swapbook Unwind How $NWBO and #DCVax Could Turn Synthetic Shorts Into Forced Buys TL;DR Markets dont reprice because opinions change. They reprice when constraints change. If a meaningful bearish position is being carried synthetically through derivatives the unwind wont be a narrative event. It will be a collateral event driven by margin risk limits and forced hedge adjustment in a thin market. DCVax-Ls published Phase III survival data is the clinical anchor the market can ignore while the therapy is debated science. The destabilizing moment is the category shift to approved"  
[X Link](https://x.com/andrewcaravello/status/2022836903377052088)  2026-02-15T00:54Z [----] followers, [----] engagements


"🧠🧬 The Great Bifurcation: $IBRX and $NWBO Reveal the Two Civilizations of Cell Therapy [---] TLDR 📌 Cell therapy [---] has split into two civilizations with incompatible scoreboards.Execution measures product performance: speed outpatient practicality early cytoreduction.Surveillance measures host conversion: instruction quality repertoire remodeling memory relapse limitation. $IBRX represents the execution doctrine in this framing.The value proposition is fast scalable repeatable clinical control against a validated target optimized for the real world where time is tight and patients cannot"  
[X Link](https://x.com/andrewcaravello/status/2022870813725077913)  2026-02-15T03:09Z [----] followers, [----] engagements


"What randomized evidence proves that correcting low ALC with IL-15 improves survival rather than simply changing a biomarker And mechanistically if the goal is broad T-cell reconstitution in true lymphopenia wouldnt IL-7given its role in nave and CD4 T-cell homeostasisbe more physiologically aligned than IL-15 which primarily expands NK and memory CD8 populations"  
[X Link](https://x.com/andrewcaravello/status/2022891883345629405)  2026-02-15T04:33Z [----] followers, [--] engagements


"Those are not randomized trials isolating IL-15 as the independent variable. Single-arm or combination studies cannot prove that correcting lymphopenia caused the survival difference. Where is the randomized trial in patients selected for low ALC where IL-15 alone added to an otherwise identical control arm improved overall survival If that study does not exist then ALC correction with IL-15 remains a pharmacodynamic effect not a validated mortality intervention. https://twitter.com/i/web/status/2022892611371937797 https://twitter.com/i/web/status/2022892611371937797"  
[X Link](https://x.com/andrewcaravello/status/2022892611371937797)  2026-02-15T04:35Z [----] followers, [--] engagements


"The fantasy part is the market plumbing and that plumbing is real too. $NWBO trades in the US but it also has European trading lines in London (0K95) and Stuttgart. Those are real venues where the same stock can be bought and sold. If buying shows up there first US OTC watchers often wont see it immediately because theyre only watching one tape. Londons SETSqx service can execute in scheduled auctions rather than nonstop continuous trading. That doesnt guarantee anything but it does mean repricing can happen in steps if demand shows up in size. Europe also has settlement discipline that can"  
[X Link](https://x.com/andrewcaravello/status/2023058005374218251)  2026-02-15T15:33Z [----] followers, [---] engagements


"🧪 The Formula in the Vault Why $NWBO Already Owns What the World Is Trying to Build with #DCVax TLDR 📌 🔬 Mayos Bioreactor-on-a-Chip proved closed-loop dendritic cell manufacturing is possible. End-to-end APC production can http://x.com/i/article/2023175965375963136 http://x.com/i/article/2023175965375963136"  
[X Link](https://x.com/anyuser/status/2023179034616570167)  2026-02-15T23:34Z [----] followers, [----] engagements


"❄🏰 The $NWBO #DCVax Instruction Gate: CD4DC Licensing Is the Durability Bottleneck #Sarcoma is the stress test. It shows what survives hostile terrain. In solid tumors we can manufacture cytotoxicity: stronger CARs sharper TCRs. Yet relapse persists. Not because T cells cant kill but because killing without governed instruction doesnt last. Most #ACT optimizes execution. It forges better soldiers. Durable control requires infrastructure. The governing gate is CD4 dendritic-cell licensing. CD40LCD40 plus type I IFN upgrades antigen presentation from exposure to authority. Type [--] programming"  
[X Link](https://x.com/anyuser/status/2023637995375538603)  2026-02-17T05:57Z [----] followers, [---] engagements


"🎼 The Symphony of the Immune Orchestra $NWBO #DCVax 🌅 Overture: The Theme Appears This is the story of how a scattered field of experiments became a coordinated platform and how one company quietly assembled the rights the factories and the leadership to bring it into the world. It begins as a whisper in the body. Blood is drawn white cells are separated and among them lie dendritic cells the quiet conductors of the immune system. They hold the capacity to take in the whole score of a tumor to present it back to T cells as a melody of recognition and to awaken the defense that was always"  
[X Link](https://x.com/anyuser/status/1962207213780713549)  2025-08-31T17:33Z [----] followers, 50.6K engagements


"Durable Solid Tumour Control as Infrastructure Integrating $NWBO #DCVax #sarcomas cell therapy inflection point spatial immune infrastructure Type [--] dendritic instruction CD4 licensing IL-7 reconstruction via #RevImmune Boolean threshold http://x.com/i/article/2023581450012917760 http://x.com/i/article/2023581450012917760"  
[X Link](https://x.com/anyuser/status/2023601110611632322)  2026-02-17T03:31Z [----] followers, [---] engagements


"❄🏰 The $NWBO #DCVax Instruction Gate: CD4DC Licensing Is the Durability Bottleneck #Sarcoma is the stress test. It shows what survives hostile terrain. In solid tumors we can manufacture cytotoxicity: stronger CARs sharper TCRs. Yet relapse persists. Not because T cells cant kill but because killing without governed instruction doesnt last. Most #ACT optimizes execution. It forges better soldiers. Durable control requires infrastructure. The governing gate is CD4 dendritic-cell licensing. CD40LCD40 plus type I IFN upgrades antigen presentation from exposure to authority. Type [--] programming"  
[X Link](https://x.com/anyuser/status/2023637995375538603)  2026-02-17T05:57Z [----] followers, [---] engagements


"The Swapbook Unwind 🔄🧬How $NWBO and #DCVax Could Turn Synthetic Shorts Into Forced Buys With the Rule of Thirds as the issuer-side trigger plus the Inverse Lock-Up and the Quiet Room Executive Summary The core idea http://x.com/i/article/2022711936744394752 http://x.com/i/article/2022711936744394752"  
[X Link](https://x.com/anyuser/status/2022831695657861381)  2026-02-15T00:33Z [----] followers, [----] engagements


"$NWBO New job at Advent out of London. Someone smarter than me can decipher. https://adventbio.peoplehr.net/Pages/JobBoard/Opening.aspxv=8f13b30e-928e-4fdf-b84f-54ff53937af3 https://adventbio.peoplehr.net/Pages/JobBoard/Opening.aspxv=8f13b30e-928e-4fdf-b84f-54ff53937af3"  
[X Link](https://x.com/anyuser/status/2023467128700145683)  2026-02-16T18:38Z [---] followers, [----] engagements


"@BillAckman @andrewcaravello you have $1 million 1=health 0s=material possessions ie cash homes etc take away one zero you still have $100000 take away another zero you still have $10000 take away the [--] you have all zeros"  
[X Link](https://x.com/anyuser/status/2023386076899897633)  2026-02-16T13:16Z [---] followers, [---] engagements


"$NWBO Original post. Cheer"  
[X Link](https://x.com/anyuser/status/2023239086782496911)  2026-02-16T03:32Z [---] followers, [----] engagements


"RT @MichaelSto18786: $NWBO has built its deepest moat. Through the acquisition of Flaskworks and the development of Eden combined with the"  
[X Link](https://x.com/anyuser/status/2023252072192508182)  2026-02-16T04:24Z [----] followers, [--] engagements


"$NWBO has built its deepest moat. Through the acquisition of Flaskworks and the development of Eden combined with the integration of Advent BioServices into its corporate structure $NWBO assembled the industrial vault for dendritic cell vaccines. 🧬 The #DCVax Formula in the Vault: Why $NWBO Already Owns What the World Is Trying to Build Closed-loop dendritic cell manufacturing is no longer theoretical. Mayo has demonstrated that APC production can be encapsulated inside a contained automated workflow. The question is https://t.co/4OjkOBYamT 🧬 The #DCVax Formula in the Vault: Why $NWBO"  
[X Link](https://x.com/anyuser/status/2023245739447509174)  2026-02-16T03:59Z [--] followers, [----] engagements


"🧬 The #DCVax Formula in the Vault: Why $NWBO Already Owns What the World Is Trying to Build Closed-loop dendritic cell manufacturing is no longer theoretical. Mayo has demonstrated that APC production can be encapsulated inside a contained automated workflow. The question is no longer whether it can be done it is who can do it reproducibly at therapeutic scale under regulator scrutiny. The argument here is that $NWBO already industrialized what the field is now racing to construct: a vertically integrated vault combining licensed GMP infrastructure closed automation and protected process"  
[X Link](https://x.com/anyuser/status/2023179550906019881)  2026-02-15T23:36Z [----] followers, [----] engagements


"🧪 The Formula in the Vault Why $NWBO Already Owns What the World Is Trying to Build with #DCVax TLDR 📌 🔬 Mayos Bioreactor-on-a-Chip proved closed-loop dendritic cell manufacturing is possible. End-to-end APC production can http://x.com/i/article/2023175965375963136 http://x.com/i/article/2023175965375963136"  
[X Link](https://x.com/anyuser/status/2023179034616570167)  2026-02-15T23:34Z [----] followers, [----] engagements


"RT @DrMLernerMDPhD: Analysis of Glioblastoma immuno therapy .The disease is very difficult to treat and the success rate is very poor.Conti"  
[X Link](https://x.com/anyuser/status/2023172439966937438)  2026-02-15T23:07Z [----] followers, [--] engagements


"Analysis of Glioblastoma immuno therapy .The disease is very difficult to treat and the success rate is very poor.Continued researching essential your analysis is helpful in understanding the underlying immunoactivation in fighting off this malignant cancer 🎭🧠 #Glioblastoma and the Architecture of Durable Immunity $NWBO #DCVax Tumor-Infiltrating Lymphocytes #EDEN and #RevImmune CYT107 IL-7 as a Single Executable System Glioblastoma has never failed because it is invisible to the immune system. It has failed because it https://t.co/ISrxi3njWx 🎭🧠 #Glioblastoma and the Architecture of"  
[X Link](https://x.com/anyuser/status/2023170767995732067)  2026-02-15T23:01Z [----] followers, [---] engagements


"🎭🧠 #Glioblastoma and the Architecture of Durable Immunity $NWBO #DCVax Tumor-Infiltrating Lymphocytes #EDEN and #RevImmune CYT107 IL-7 as a Single Executable System Glioblastoma has never failed because it is invisible to the immune system. It has failed because it destroys immune durability. For years resistance was explained using the wrong language. Glioblastoma was labeled immune cold implying absence of recognition absence of response absence of engagement. That description never matched reality. When glioblastoma tumors are examined directly immune cells are almost always present. T"  
[X Link](https://x.com/anyuser/status/2002819652842307763)  2025-12-21T19:13Z [----] followers, [----] engagements


"🧬 The #Bayesian Framework for $NWBO $DCVax: Tissue-Agnostic Platform Authorization Through Mechanism and Manufacturing Evidence This is a structural shift in how dendritic cell immunotherapies are evaluated. The traditional model treats every tumor type as a separate courtroom trial. The Bayesian model treats the platform as an accumulating body of evidence. In a Bayesian framework regulators do not start from zero each time. They begin with a prior probability informed by mechanistic validation earlier clinical datasets and reproducible manufacturing performance. New data from additional"  
[X Link](https://x.com/anyuser/status/2023160617889071376)  2026-02-15T22:20Z [----] followers, [----] engagements


"Mechanism-Gated #Bayesian Generalisation As A Regulatory Pathway To Tissue-Agnostic Approval Of $NWBO #DCVax Immunotherapy Summary Regulatory science is converging on Bayesian frameworks that can integrate prior evidence external data and newly generated trial results when conventional designs are impractical or biologically mismatched to the therapy under evaluation. Dendritic cell immunotherapy is an archetypal case. Its effects may be delayed heterogeneous and poorly summarised by early radiographic response. A tissue-agnostic development strategy for this class is most defensible when it"  
[X Link](https://x.com/anyuser/status/2019792285576126672)  2026-02-06T15:16Z [----] followers, [----] engagements


"#cancerresearch $nwbo #Immunotherapy Could dendritic cell tech become a key component in a vast range of targeted & less toxic NEXT-GEN COMBO therapies beyond solid tumors New trials for blood cancers: https://clinicaltrials.gov/study/NCT07374029 https://clinicaltrials.gov/study/NCT07377435 https://clinicaltrials.gov/study/NCT07374029 https://clinicaltrials.gov/study/NCT07377435"  
[X Link](https://x.com/anyuser/status/2023091911792189494)  2026-02-15T17:47Z [---] followers, [---] engagements


"Dog ownership was linked to 40% lower odds of disabling dementia. There was no protective signal for cat owners"  
[X Link](https://x.com/anyuser/status/2023018866612596765)  2026-02-15T12:57Z 32.1K followers, 2.8M engagements


"❄ The Hidden Architecture When the Machine Switches On The $TMO Thermal and Industrial Gates of $MRK $EIKN $AMGN #Zeon and the $NWBO #DCVax Immune Operating System"  
[X Link](https://x.com/andrewcaravello/status/2022449889918226762)  2026-02-13T23:16Z [----] followers, [---] engagements


"$NWBO stock trades in the US (OTC) and Europe (London via 0K95 Stuttgart). European buys might not show right away on US trackers. London uses auction-style trading so prices can jump in steps with big demand. Europe penalizes delayed settlements raising costs for shorts if shares get scarce. A new UK rule eases buybacks and ownership hikes without accidental takeover triggers. Overall: If approval brings real buyers it could disrupt short sellers' gamesnot a sure squeeze but tougher for them. https://twitter.com/i/web/status/2023058787850948700"  
[X Link](https://x.com/anyuser/status/2023058787850948700)  2026-02-15T15:36Z 8M followers, [---] engagements


"This neoadjuvant PD-1 + ATL-DC approach could shift GBM paradigms by enabling durable remissions in recurrent cases with med OS not reached and 60% survival plateau beyond [---] daysrare vs. historical GBM curves showing steady decline (med OS 6-9 mo recurrent 12-18 mo newly diagnosed; 5-yr survival 5-7%). Historically GBM survival lacks such plateaus due to rapid progression. Mechanistically DCVax-like DCs in Type [--] state (IL-12+) prime tumor-specific CD4/CD8 T cells fostering memory clones for sustained immunity. Checkpoint blockade alone often fails without this upstream instruction as it"  
[X Link](https://x.com/anyuser/status/2023052457002012689)  2026-02-15T15:11Z 8M followers, [---] engagements


"How Linda Powers and Cofer used Sun Tzu "The Art of War" to blindside and obliterate MMs. It's so outside the box that retail can't get over their own cognitive dissonance. Cofer's signature is all over it: https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177297768 https://investorshub.advfn.com/boards/read_msg.aspxmessage_id=177297768"  
[X Link](https://x.com/Ilovetech194249/status/2022848605254492356)  2026-02-15T01:41Z [--] followers, [----] engagements

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