Dark | Light
# ![@UrnovFyodor Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1067548376944660480.png) @UrnovFyodor Fyodor Urnov

Fyodor Urnov posts on X about vivo, investment, beam, tide the most. They currently have [------] followers and [---] posts still getting attention that total [--] engagements in the last [--] hours.

### Engagements: undefined [#](/creator/twitter::1067548376944660480/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1067548376944660480/c:line/m:interactions.svg)

- [--] Months [--] -100%
- [--] Year [-----] -97%

### Mentions: undefined [#](/creator/twitter::1067548376944660480/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1067548376944660480/c:line/m:posts_active.svg)


### Followers: [------] [#](/creator/twitter::1067548376944660480/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1067548376944660480/c:line/m:followers.svg)

- [--] Month [------] +18%
- [--] Months [------] +40%
- [--] Year [------] +43%

### CreatorRank: undefined [#](/creator/twitter::1067548376944660480/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1067548376944660480/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[finance](/list/finance)  9.9% [technology brands](/list/technology-brands)  5.94% [celebrities](/list/celebrities)  3.96% [stocks](/list/stocks)  3.96% [countries](/list/countries)  3.96% [ncaa football](/list/ncaa-football)  3.96% [musicians](/list/musicians)  1.98% [travel destinations](/list/travel-destinations)  1.98% [automotive brands](/list/automotive-brands)  0.99% [currencies](/list/currencies)  0.99%

**Social topic influence**
[vivo](/topic/vivo) 3.96%, [investment](/topic/investment) 2.97%, [beam](/topic/beam) 2.97%, [tide](/topic/tide) 1.98%, [india](/topic/india) 1.98%, [money](/topic/money) 1.98%, [have the](/topic/have-the) 0.99%, [products](/topic/products) 0.99%, [target](/topic/target) 0.99%, [if you](/topic/if-you) 0.99%

**Top accounts mentioned or mentioned by**
[@igisci](/creator/undefined) [@statnews](/creator/undefined) [@adeangelisbio](/creator/undefined) [@danahercorp](/creator/undefined) [@bradloncar](/creator/undefined) [@pennmedicine](/creator/undefined) [@kiranmusunuru](/creator/undefined) [@adamfeuerstein](/creator/undefined) [@ucberkeley](/creator/undefined) [@johndoench](/creator/undefined) [@editasmed](/creator/undefined) [@naturebiotech](/creator/undefined) [@intelliatx](/creator/undefined) [@hoperhenderson](/creator/undefined) [@nature](/creator/undefined) [@meganmolteni](/creator/undefined) [@geneinvesting](/creator/undefined) [@jasonmmast](/creator/undefined) [@matthewherper](/creator/undefined) [@stjuderesearch](/creator/undefined)

**Top assets mentioned**
[BEAM (BEAM)](/topic/beam) [AbbVie Inc (ABBV)](/topic/$abbv) [MAYA (MAYA)](/topic/maya) [Goldman Sachs (GS)](/topic/goldman-sachs) [Intellia Therapeutics, Inc (NTLA)](/topic/$ntla) [Alphabet Inc Class A (GOOGL)](/topic/google) [Euler (EUL)](/topic/euler) [Pfizer, Inc. (PFE)](/topic/$pfe) [GARY (GARY)](/topic/gary) [Enzyme (MLN)](/topic/enzyme) [Harmony (ONE)](/topic/harmony) [Optimism (OP)](/topic/optimism) [Handshake (HNS)](/topic/handshake)
### Top Social Posts
Top posts by engagements in the last [--] hours

"@bradloncar Mmmm Fate (and Allogene and Sangamo Cellectis Caribou Editas Intellia CRISPR Beam) have the entire editing toolbox they can use to make their product(s) better if they want to. And the entire genome as a potential target"  
[X Link](https://x.com/UrnovFyodor/status/1428715972777500672)  2021-08-20T13:50Z 22.4K followers, [--] engagements


"I have zero street cred in threads - but the TIDE analysis Synthego provides is rock-solid and consistently useful and has near-no learning curve (in terms of enabling folks who are not professional editors to get their data)"  
[X Link](https://x.com/UrnovFyodor/status/1678449645457137664)  2023-07-10T17:14Z 13.9K followers, [----] engagements


"Dr Shondra Miller the PI for this newly opened position is the gene editing version of Captain Marvel. If you think this is hyperbole ask anyone who has actually worked with her. AND @StJudeResearch hosts some of THE best gene editors in our field"  
[X Link](https://x.com/UrnovFyodor/status/1694085708821209584)  2023-08-22T20:34Z 13.9K followers, [---] engagements


"Expanding the public health impact of CRISPR to address N=1/rare disease will require scientists in industry and in academia to collaborate and jointly become "the rising tide that lifts all boats." Here's a gr9 (98) example"  
[X Link](https://x.com/UrnovFyodor/status/1696611424964162000)  2023-08-29T19:50Z 13.8K followers, [---] engagements


"20000 persons have received CAR-T / TCR-T therapy thanks to the skill and courage of the @PennMedicine team led by Carl June to initial curative outcomes. Carl and colleagues did the first clinical trial for genome editing - paving the way for the Age of CRISPR in the Clinic"  
[X Link](https://x.com/UrnovFyodor/status/1702645270050439320)  2023-09-15T11:27Z 13.8K followers, [----] engagements


"The path through this to #HealthJustice: [--]. Editing vs gene therapy. [--]. In vivo vs ex vivo. Both WILL happen. Sole issue: pricing ex-US (in US in vivo editing will still be [--] figures despite 4-figure COGs). Superb piece @DrewQJoseph https://www.statnews.com/2023/10/04/gene-therapy-makers-wonder-if-they-can-make-a-profit-in-europe-patients-fear-being-left-behind-again/ https://www.statnews.com/2023/10/04/gene-therapy-makers-wonder-if-they-can-make-a-profit-in-europe-patients-fear-being-left-behind-again/"  
[X Link](https://x.com/UrnovFyodor/status/1709549568185274803)  2023-10-04T12:42Z 15.7K followers, [----] engagements


"A huge step for Intellia and a bigger one for the field of editing the human liver: as I learned from @kiranmusunuru there are [----] newborns in the US with editable inborn errors of immunity. A majority could be edited to health one-and-done in this way"  
[X Link](https://x.com/UrnovFyodor/status/1714632372002717974)  2023-10-18T13:19Z 13.5K followers, [----] engagements


"1. Base editing is a powerful + flexible technology for clinic-grade repair of mutations leveraged into ex vivo + in vivo approaches. [--]. Team Beam is SUPERB. = a glaring example imho of the disconnect between The Street's take and sector fundamentals"  
[X Link](https://x.com/UrnovFyodor/status/1715069484598473142)  2023-10-19T18:16Z 13.5K followers, 11.2K engagements


"@JustinAPater @JohnDoench @nathanwpyle @dccc_phd I think there is some conspiracy around DD. What other explanation is there Here is a Seattle roadmap for anyone from Beantown who seeks [--] separate examples of The Truth. Which is out there. (fwiw to me Vivace is Messi and Vita is Bonham on drums)"  
[X Link](https://x.com/UrnovFyodor/status/1719478607469310322)  2023-10-31T22:17Z 13.6K followers, [--] engagements


"BRAVO @editasmed - what a class act To all the zero-sum-gamers out there who think life is MMA tragically glued to your puerile Weltanschauung of "who will win" - learn from this: one biotech congratulating another in a field where they are allegedly direct competitors"  
[X Link](https://x.com/UrnovFyodor/status/1725174096831386062)  2023-11-16T15:28Z 13.7K followers, 14.3K engagements


"@NKWhiteman Quoting Denzel Washington from Philadelphia: explain it to me like I am a [--] year old. What specific method of preparing coffee retains the most terpenoids in the resulting coffee"  
[X Link](https://x.com/UrnovFyodor/status/1727068443797799114)  2023-11-21T20:56Z 13.8K followers, [----] engagements


""Monetization of existing content" is the trend @apcbapcb is concerned by - as if McCartney is Abbvie milking the patent system for Humira It's not an either/or with originality: listen to @mashupmartin genius remix of Revolver"  
[X Link](https://x.com/UrnovFyodor/status/1728768273796505654)  2023-11-26T13:30Z 13.8K followers, [---] engagements


"Casgevy is a landmark for genetic medicine and for gene editing (CoI disclosure below). And yet market forces have shrunk active pipelines of [--] leading gene editing biotechs to [--] diseases. CRISPR can be curative. We cannot lose that momentum"  
[X Link](https://x.com/UrnovFyodor/status/1731800085477155136)  2023-12-04T22:18Z 13.8K followers, [----] engagements


""Ive escaped from the clutch of fear that comes from thinking every occasion could be my last." Oh my heart. THIS folks is what CRISPR can do. THIS is why we MUST expand its public health footprint"  
[X Link](https://x.com/UrnovFyodor/status/1731810791601361331)  2023-12-04T23:00Z 13.8K followers, [----] engagements


"$ CoI disclosure: I am a paid consultant to Vertex Pharmaceuticals on the exa-cel program"  
[X Link](https://x.com/UrnovFyodor/status/1731810793270968405)  2023-12-04T23:00Z 13.8K followers, [---] engagements


"Hear hear Go MTx I look slightly insane here because the news of Casgevy approval broke [--] min before this photograph was taken and Jennifer was LITERALLY the first person I ran into at the retreat; in this picture quoting Dua Lipa I'm levitating"  
[X Link](https://x.com/UrnovFyodor/status/1733528732747641012)  2023-12-09T16:47Z 13.9K followers, [----] engagements


"1. What does Casgevy mean for gene editors [--]. What is next on the #CRISPR cures horizon [--]. Will base/prime editing supplant classical editing. [--]. What is @igisci up to What a treat to meet @bradloncar - a sane and sage mind - in person. Brad is every bit the real deal"  
[X Link](https://x.com/UrnovFyodor/status/1735080684459626887)  2023-12-13T23:34Z 14K followers, 16.6K engagements


"@sciliz @pknoepfler I wasn't aware of this. In the eloquent words of Bob Seeger: "Wish I didn't know now what I didn't know then" Cults have been with humankind for the entirety of its recorded history. The cult of anti-GMO - commercialized by vendors peddling "safer" non-GMO food - harms the world"  
[X Link](https://x.com/UrnovFyodor/status/1735731306573729904)  2023-12-15T18:39Z 14K followers, [--] engagements


"@adamfeuerstein Holy [--] Mole-y. Your analogy to a pawn shop is pitch-perfect then. WOW"  
[X Link](https://x.com/UrnovFyodor/status/1736876839317164261)  2023-12-18T22:31Z 13.8K followers, [---] engagements


"This is an outrage and a profound injustice. The @igisci @DanaherCorp Beacon for CRISPR Cures is not run by the naive - we are all realists and veterans of developing gene editing medicines in the real world. We are confident in our ability to develop and deliver for all to use a scalable portable affordable approach to develop and provide gene editing medicines for neurologic diseases treatable by repairing blood stem cells - such as the one this child is suffering from. #HealthJustice"  
[X Link](https://x.com/UrnovFyodor/status/1744787017546989961)  2024-01-09T18:23Z 13.5K followers, [----] engagements


"Genetic disease knows no borders. Neither should #CRISPR cures. Essential reading by @drbenjohnson @NatureBiotech . showcasing the #yeswecan approach to providing gene therapy cures in India Brazil Thailand and beyond. A key goal of the @igisci @DanaherCorp Beacon for CRISPR Cures is to have gene editing follow that example and build Platform approaches to make such cures affordable manufacturable and deliverable to patients where the unmet medical need is and not just where the current GMP suites are. #HealthJustice"  
[X Link](https://x.com/UrnovFyodor/status/1746934424560939505)  2024-01-15T16:36Z 13.9K followers, [----] engagements


"The @igisci @DanaherCorp Beacon for CRISPR Cures seeks: . to build+take to clinic two gene editing medicines for severely ill children. . a talented project manager to work with an amazing team in making that happen. Link to job posting below - pls RT"  
[X Link](https://x.com/UrnovFyodor/status/1747401297354178749)  2024-01-16T23:31Z 13.6K followers, [----] engagements


"Something tells me US-approved biosimilars for gene therapies will not fare better. For gene editing in "rare" disease - we need to and will get to a world where the COGs of developing and administering a dose of nonviral #CRISPR is $200k"  
[X Link](https://x.com/UrnovFyodor/status/1747745111109517517)  2024-01-17T22:18Z 14.2K followers, [----] engagements


"Gr9 (98) ball movement and gr9 touch from downtown. @KemeryM #GoBears 3rd time's the charm πŸ€ @KemeryM https://t.co/SHzXOSDxVM 3rd time's the charm πŸ€ @KemeryM https://t.co/SHzXOSDxVM"  
[X Link](https://x.com/anyuser/status/1749176170070094170)  2024-01-21T21:04Z [--] followers, [----] engagements


"Duck season πŸ€£πŸ‘πŸ»πŸ’― #GoBears"  
[X Link](https://x.com/UrnovFyodor/status/1749189899939647863)  2024-01-21T21:59Z 13.9K followers, [--] engagements


"#CRISPR is a platform for cures. @intelliatx describes a second "nothing but net" clinical dataset on liver editing that technologically is a copy-paste of an earlier such effort (34215024) in a different disease. Only the guide RNA is different. We HAVE to expand this platform to treat 1000s of newborns with severe metabolic disease (h/t @kiranmusunuru) who can be cured using this approach. At the present time no for-profit biotech will take this on. Intellia - who has absolutely best-in-class editing data - had to lay off staff (). This is where the academic/nonprofit sector comes in."  
[X Link](https://x.com/UrnovFyodor/status/1753454976473698550)  2024-02-02T16:26Z 14.3K followers, [----] engagements


"@_WhitneyLauren @scifri This is THE issue. I will post some key publications coming out from the @igisci on this topic and tag you when I do so - this will happen in the next [--] weeks. Thank you VERY much for bringing this up"  
[X Link](https://x.com/UrnovFyodor/status/1753745406075490721)  2024-02-03T11:41Z 14.3K followers, [---] engagements


"Leave. Tracy. Chapman. ALONE. @sisario @hknightsf Her oeuvre is without rival in popular music in its beauty sincerity humanity and everlasting relevance. She gave her heart and soul to it. She has a right to be as private as she wants. I come to the city a lot and if I see her despite wanting to fall down on both knees before her I will respect her privacy. Everyone should do same. #TracyChapman"  
[X Link](https://x.com/UrnovFyodor/status/1755030209970286786)  2024-02-07T00:46Z 14.3K followers, [---] engagements


"@hoperhenderson The Life You Save May Be Your Own The Maya Hawke film about her is superb. Wildcat"  
[X Link](https://x.com/UrnovFyodor/status/1756861679059767621)  2024-02-12T02:03Z 14.3K followers, [---] engagements


"@hoperhenderson The iconic A Good Man Is Hard to Find is absolutely sui generis of course"  
[X Link](https://x.com/UrnovFyodor/status/1756862073433419944)  2024-02-12T02:05Z 14.4K followers, [---] engagements


".@marilenharo Thank you for covering newer technologies in genetic medicine space. "Move over CRISPR" Please refrain from zero-sum-game-ism. This is the realm of some in the investment community (vide infra) but is below the dignity of @nature"  
[X Link](https://x.com/UrnovFyodor/status/1759401769409630473)  2024-02-19T02:17Z 14.4K followers, [----] engagements


"There is goodness in in our troubled world. There IS. Exhibit 1A: work led @UCSF by Dr. Tippi MacKenzie @MackenzieTippi to use #CRISPR and treat severe genetic disease before it does irreversible harm. Inspiring reporting by @MeganMolteni @statnews"  
[X Link](https://x.com/UrnovFyodor/status/1760293595079438757)  2024-02-21T13:21Z 14.5K followers, [----] engagements


"A glaring example of why the academic/nonprofit sector has to take a larger role in #CRISPR N=rare cures. @intelliatx has THE best clinical data in the entire field. AND a platform to build more. = this Goldman Sachs "slasher" is a random number generator. H/t @GeneInvesting $NTLA Goldman Sachs slashes Intellia Therapeutics price target to $32 from $136 downgrades to Neutral from Buy; Canaccord Genuity raises target to $73 from $72 Buy rating. $NTLA Goldman Sachs slashes Intellia Therapeutics price target to $32 from $136 downgrades to Neutral from Buy; Canaccord Genuity raises target to $73"  
[X Link](https://x.com/UrnovFyodor/status/1761477808168264140)  2024-02-24T19:46Z 14.6K followers, 45.4K engagements


"This is NOT investment advice. I am an SME in the technology (gene editing) and how to put it into the clinic and what the unmet need is and what the broader range of impact of specific technologies in this space is"  
[X Link](https://x.com/UrnovFyodor/status/1761477809527193821)  2024-02-24T19:46Z 14.5K followers, [----] engagements


""Estamos tocando tiki-taka tiki-taka" [--] years after the above was said for the first time the supreme practitioners of this magical style are in prime form. #Messi Messi πŸ”— Alba WHAT A GOAL https://t.co/LuYpsiAb2X Messi πŸ”— Alba WHAT A GOAL https://t.co/LuYpsiAb2X"  
[X Link](https://x.com/UrnovFyodor/status/1762176025528783004)  2024-02-26T18:01Z 14.5K followers, [----] engagements


"@asparks1010100 @NatureBiotech Rule [--] of my field is never ever give families false hope. With that. [--]. The US Federal Government has funded a Navy Seal Team 6-grade constellation of gene editors and physicians to develop a gene editing treatment for PKU. [--]. Tessera is working on this as well. 1+2=progress"  
[X Link](https://x.com/UrnovFyodor/status/1762522367136571425)  2024-02-27T16:57Z 14.5K followers, [--] engagements


"@NatPress @Stanford @igisci I admire the scientists and physicians who make @stanford one of the gems in the constellation of research universities. With that. I am a professor at @UCBerkeley where the @igisci is and from which we welcome our friends in Palo Alto to learn from us as much as they need to"  
[X Link](https://x.com/UrnovFyodor/status/1763234095537279318)  2024-02-29T16:05Z 14.5K followers, [---] engagements


"Well folks if Google - which built its $1.7 trillion market cap on analysis of data - makes this mistake . this is an actual screen cap of an autocorrect gmail suggested for an e-mail I was writing ChatGPT [--] - next tweet - is taking both sides. Words - other than "data" - fail me"  
[X Link](https://x.com/UrnovFyodor/status/1764673074593730853)  2024-03-04T15:23Z 14.6K followers, [----] engagements


"Neither the film #Oppenheimer nor this @Nature piece . about its science has ANY substantive discussion about what surely is the only issue that matters: a group of brilliant scientists designed and had built a horrific weapon of civilian mass murder. How did they FEEL about that How do physicists feel about it NOW The goal is not to assign blame - but to assign meaning to this devastating intersection between fundamental science and the real world"  
[X Link](https://x.com/UrnovFyodor/status/1767196903136256155)  2024-03-11T14:32Z 14.6K followers, [----] engagements


"More short-termist lemmingage (lemmingism) from the Street. The fundamentals here are VERY strong. = yet more reasons why the academic/nonprofit sector is stepping up to the plate on CRISPR cures. Caribou reaction to earnings makes little sense to me or anyone. Progressing [--] programs [--] of which show data this year and burning VERY little compared to other companies. Only negative is pausing CB-020 hard to imagine shelving ONE very early non-clinical program is worth Caribou reaction to earnings makes little sense to me or anyone. Progressing [--] programs [--] of which show data this year and"  
[X Link](https://x.com/UrnovFyodor/status/1767579336113316010)  2024-03-12T15:52Z 14.6K followers, [----] engagements


"A superb read from @Jasonmmast on the "last mile" problem in gene therapy - how to get an approved medicine to a patient. Building the cure does not equal curing someone in the real world folks. #VerticalIntegrationIsAMust Hemophilia gene therapies arrived after [--] years of struggle. Where are the patients https://t.co/SZW1fhv8dL Hemophilia gene therapies arrived after [--] years of struggle. Where are the patients https://t.co/SZW1fhv8dL"  
[X Link](https://x.com/UrnovFyodor/status/1767919351695610038)  2024-03-13T14:23Z 15.5K followers, [----] engagements


"It's Sunday and this one is for @JohnDoench. I would like to change all my social media handles and userids to: BornToTunAGel What are your thoughts"  
[X Link](https://x.com/UrnovFyodor/status/1769491103739494721)  2024-03-17T22:28Z 14.6K followers, [----] engagements


".@aurmanARK's pithy prcis of a key challenge for our field @statnews summit: How does a curative therapy command the pricing that it needs to command in order for investors to get back their money but also get it to people that need it most"  
[X Link](https://x.com/UrnovFyodor/status/1771325804884160728)  2024-03-22T23:59Z 14.6K followers, [----] engagements


"It's late Sunday morning. Trivia time. I just learned that Sudoku was invented by Euler in the mid-18th century. Euler also invented the f(x) notation. And in passim Euler's identity"  
[X Link](https://x.com/UrnovFyodor/status/1771937895651189240)  2024-03-24T16:31Z 14.7K followers, [----] engagements


"Re a transient SAE on a gene editing trial. Reminder: Back in 2012: The first CAR-T patient Emily Whitehead was within [--] hrs of dying from a never before seen SAE. The clinicians course-adjusted. 2024: CAR-T - [-----] patients treated with [--] commercial products"  
[X Link](https://x.com/UrnovFyodor/status/1775125604477600129)  2024-04-02T11:38Z 14.7K followers, [----] engagements


"@LukashPlatil Could you explain what a "debt stack" is πŸ™"  
[X Link](https://x.com/UrnovFyodor/status/1776230809013264570)  2024-04-05T12:50Z 15K followers, [--] engagements


"Critically ill newborns in Northern India diagnosed w genetic disease by rapid sequencing. We WILL have a world where blood and liver disease in such children will be #CRISPR editable within [--] months at a COGs $10k. ALL the technologies exist NOW. https://www.nature.com/articles/s41431-024-01569-z https://www.nature.com/articles/s41431-024-01569-z"  
[X Link](https://x.com/UrnovFyodor/status/1778802569575588339)  2024-04-12T15:09Z 14.7K followers, 38K engagements


"The curative potential of #CRISPR gene editing has been established - yet pipelines of for-profit editing biotechs have shrunk. I appreciate the @asgct for the opportunity to share the podium with fellow SMEs in editing and speak with federal legislators about real-world change required here. #Geneediting has the potential to transform treatment for #rarediseases. A recent Capitol Hill briefing introduced congressional staffers to the underlying science of gene editing + considerations for patients. Watch now. https://t.co/za3YAvSVWR #ASGCTadvocacy #Geneediting has the potential to transform"  
[X Link](https://x.com/UrnovFyodor/status/1780250823643238579)  2024-04-16T15:04Z 14.7K followers, [----] engagements


"Lubert Stryer passed away - his name never will. His Well Tempered Clavier of a textbook came out in the USSR in [----]. I started college in [----] and slept with it under my pillow. I very nearly brought it with me to the USA when I emigrated in [----]. #CoalsToNewcastle"  
[X Link](https://x.com/UrnovFyodor/status/1780260908381712654)  2024-04-16T15:44Z 14.7K followers, [----] engagements


"@matthewherper Hear hear. If in Vienna go see this. It does not travel for some reason (eg it was not in the recent pan-Vermeer show in Amsterdam). https://en.wikipedia.org/wiki/The_Art_of_Painting https://en.wikipedia.org/wiki/The_Art_of_Painting"  
[X Link](https://x.com/UrnovFyodor/status/1780933775087817043)  2024-04-18T12:17Z 14.7K followers, [---] engagements


"Imagine combining: [--] - 23andMe data on folks who "have" genetic disease - but not clinically (v.i.) [--] - CRISPR to map protective variants [--] - making them in the clinic la Casgevy All the technologies exist. Just not inside 23andMe. @ADeAngelis_bio https://www.statnews.com/2024/04/18/23andme-anne-wojcicki-moves-to-take-company-private/ https://www.statnews.com/2024/04/18/23andme-anne-wojcicki-moves-to-take-company-private/"  
[X Link](https://x.com/UrnovFyodor/status/1782119688740524424)  2024-04-21T18:50Z 14.7K followers, [----] engagements


"@matthewherper @ADeAngelis_bio I think technology companies tend to have canalized worldviews. They think if they solved for step B then steps A and C-Z will magically happen. In this case they needed an Avengers-like vertical integration of capabilities and to bring Goldilocks partners in. Eg KSQ and Prime"  
[X Link](https://x.com/UrnovFyodor/status/1782133575523213645)  2024-04-21T19:45Z 14.7K followers, [---] engagements


"What actually happened: AI produced CRISPR-inspired genome editors that have modest on-target activity in human cancer cells. Impact on actual clinical editing in next [--] years: none. Long term - I sure hope so. I think X needs better AI to write these "Explore" blurbs. :-)"  
[X Link](https://x.com/UrnovFyodor/status/1782545025307652363)  2024-04-22T23:00Z 14.8K followers, [----] engagements


"I admire @Regeneron for its commitment to gene-edited therapies. Earlier bringing in [---] and Philip Gregory a superstar to run edited CAR-T programs - now bringing in Team @mammothbiosci - quite a constellation of shining stars themselves 1+2=7 synergy there. We look forward to working with @Regeneron to enable all-in-one AAV delivery and unlock the true potential of in vivo gene editing. Read our press release to learn more: https://t.co/RGyzFq7LhI @doudna_lab @UCBerkeley https://t.co/jFzNtpfjYr We look forward to working with @Regeneron to enable all-in-one AAV delivery and unlock the true"  
[X Link](https://x.com/UrnovFyodor/status/1783488568532562163)  2024-04-25T13:29Z 14.8K followers, [----] engagements


"Pfizer is _commercializing_ this therapy. It was _developed_ by Spark Therapeutics under the leadership of Dr Katherine High @PennMedicine. She also built Luxturna - the first approved AAV medicine. Dr High is a hero and inspiration to all working in our field. #WomenInSTEM Pfizers first gene therapy a $3.5 million one-time treatment for hemophilia B enters a market that has vexed other drugmakers https://t.co/QHoNnOuIqs $pfe Pfizers first gene therapy a $3.5 million one-time treatment for hemophilia B enters a market that has vexed other drugmakers https://t.co/QHoNnOuIqs $pfe"  
[X Link](https://x.com/UrnovFyodor/status/1783907393551929545)  2024-04-26T17:14Z 14.9K followers, [----] engagements


"@anandcpatelmdms @PennMedicine Mm No disagreement on anything there. I could not find her name mentioned in any of the PR I read - and wanted to remedy that in my own small way"  
[X Link](https://x.com/UrnovFyodor/status/1784191479331823849)  2024-04-27T12:02Z 14.8K followers, [---] engagements


"CRISPR medicine #1 - change just the guide RNA spacer (20 nt) keep all else the same - CRISPR medicine #2. Intellia has done this (TTR-HAE). πŸ‘ PJ Brooks πŸ™πŸ™πŸ™is the lead architect of a federal program to do this. #yeswecan H/t @AAMortazavi https://www.cgtlive.com/view/nih-strategizes-to-streamline-gene-therapy-development https://www.cgtlive.com/view/nih-strategizes-to-streamline-gene-therapy-development"  
[X Link](https://x.com/UrnovFyodor/status/1786383869966737621)  2024-05-03T13:14Z 14.9K followers, [----] engagements


"Three subjects dosed with base-edited cells In the words of Bruce Springsteen it's been a long time coming my dear it's been a long time coming but now it's here Gregorspeed Beam Excited to share that we have now completed dosing and successful engraftment of all three sentinel patients in the BEAM-101 BEACON trial for sickle cell disease. Expansion dosing will now proceed with the next dose occurring shortly. https://t.co/xAcXR9umDr Excited to share that we have now completed dosing and successful engraftment of all three sentinel patients in the BEAM-101 BEACON trial for sickle cell"  
[X Link](https://x.com/UrnovFyodor/status/1787918282504421554)  2024-05-07T18:51Z 14.9K followers, [----] engagements


"@GeneInvesting @RTLeenay I have a greater bias for this than a Kpop fan for their idol but I am arguing that no matter the modality KO repair TI epi - editing is fundamentally distinct from absolutely everything else in the field (RNAi ASO AAV lenti). And the difference makes a difference"  
[X Link](https://x.com/UrnovFyodor/status/1787952040658038869)  2024-05-07T21:05Z 14.9K followers, [---] engagements


"Encouraging words from Kimberly Powell (VP Heathcare Nvidia) @statnews #statbreakthrough: AI will accelerate path to N=1/rare medicines"  
[X Link](https://x.com/UrnovFyodor/status/1791148783629406719)  2024-05-16T16:48Z 14.9K followers, [----] engagements


"I would not be eligible for a picomole of this award without @berkeleyMCB PhD graduate Michael Holmes who co-developed the genome editing toolbox and @UCBerkeley's own Johann Gutenberg Dr Jennifer Doudna who invented the cognate of the printing press in gene editing. Fiat Lux Congrats to MCB's Fyodor Urnov @UrnovFyodor on being awarded the Horace Mann Medal from @BrownGradSchool πŸ‘πŸŽ‰ https://t.co/efwWdCZZGQ Congrats to MCB's Fyodor Urnov @UrnovFyodor on being awarded the Horace Mann Medal from @BrownGradSchool πŸ‘πŸŽ‰ https://t.co/efwWdCZZGQ"  
[X Link](https://x.com/UrnovFyodor/status/1792895815431680181)  2024-05-21T12:30Z 15K followers, [----] engagements


"It speaks sad volumes to the investment climate in gene editing when scientific talks at a scientific meeting by scientists at for-profit companies are . not science talks. They are investor pitch decks. My heart goes out to all my fellow scientists in this unjust predicament"  
[X Link](https://x.com/UrnovFyodor/status/1796603312428785735)  2024-05-31T18:03Z 15K followers, [----] engagements


"A path to platform #CRISPR cures is here - fragmented across universities biotechs and CDMOs. How do we weave a curative quilt out of the disconnected bits and pieces πŸ™πŸ™πŸ™ @ElliotHershberg for a thoughtful and clear answer in https://centuryofbio.com/p/scaling-crispr-cures http://centuryofbio.com https://centuryofbio.com/p/scaling-crispr-cures http://centuryofbio.com"  
[X Link](https://x.com/UrnovFyodor/status/1797959660663910810)  2024-06-04T11:52Z 15.1K followers, [----] engagements


"The Horace Mann lecture I gave @BrownUniversity has a [--] min subunit - ca 49m30s-56m30s - that distills the vision for gene editing as a platform to build medicines for genetic disease - the goal for the @igisci @DanaherCorp Beacon for CRISPR Cures. https://youtu.be/yhQ_paaNw9csi=jNagCj-9iOR3uIbl https://youtu.be/yhQ_paaNw9csi=jNagCj-9iOR3uIbl"  
[X Link](https://x.com/UrnovFyodor/status/1798535059659800944)  2024-06-06T01:59Z 15.1K followers, [----] engagements


"The full lecture gave me a key opportunity to honor my mentors at Brown Drs Susan Gerbi Art Landy and Ken Miller my postdoctoral mentor Dr Alan Wolffe and my colleagues at Sangamo Philip Gregory Mike Holmes Ed Rebar and Gary Lee. The Horace Mann Medal is theirs too"  
[X Link](https://x.com/UrnovFyodor/status/1798535061114929385)  2024-06-06T01:59Z 15.1K followers, [---] engagements


"@MitchellReed09 I appreciate your take. The issue here is I was happy to work with Vertex because I'm an SME in this exact space. So I felt I was contributing to public health (in a small but nonzero way). Let me ask some professional ethicists what the US and global legal standard here is"  
[X Link](https://x.com/UrnovFyodor/status/1801637411702902856)  2024-06-14T15:26Z 15.1K followers, [---] engagements


"You could not ask for better data for #CRISPR gene editing in sickle - [--] subjects free of VOCs total Hb 14g/dl 40% HbF. Bravo @editasmed My personal take is we're on a path to [--] approved potent genetic medicines for SCD - Casgevy Lyfgenia and the Editas product. Good morning from #EHA2024 Today we are presenting clinical data from the RUBY trial of reni-cel for the treatment of severe sickle cell disease. Learn more: https://t.co/PtYvEiYFvR #sicklecelldisease #geneediting #biotechnology https://t.co/x29gznm1PJ Good morning from #EHA2024 Today we are presenting clinical data from the RUBY"  
[X Link](https://x.com/UrnovFyodor/status/1801936468820279322)  2024-06-15T11:15Z 15.1K followers, [----] engagements


"Editas uses a different RNA-guided editor (the enzyme formerly known as Cpf1 - Cas12a) and a different genetic target (the HBG1/2 promoter) than Casgevy (Cas9 and BCL11A enhancer). [--] - yay growing toolbox of clinical CRISPR [--] - yay editing of regulatory DNA to treat disease"  
[X Link](https://x.com/UrnovFyodor/status/1801936470367944841)  2024-06-15T11:15Z 15.1K followers, [---] engagements


"@MarkusElsner1 My direct experience with their Scandinavian cognates is that it has to do with money. They lose their income if their raison dtre no longer exists due to hard data"  
[X Link](https://x.com/UrnovFyodor/status/1802006354833617377)  2024-06-15T15:52Z 15.1K followers, [---] engagements


"@natashaloder @bradloncar It's going to be progressive. The lung is currently editable in vivo as is hematopoiesis (also in vivo). Between liver lung and blood - that is an exceptionally large landscape for CRISPR cure deployment (think COPD and IBD)"  
[X Link](https://x.com/UrnovFyodor/status/1805941930175672714)  2024-06-26T12:31Z 15.2K followers, [--] engagements


"Coach Eliza @epierre4 is currently coaching a basketball summer camp here on campus for 8-12 yo girls. My [--] yo and her best friend cannot WAIT to return to it. Caring devoted talented and accomplished folks like Coach Eliza are what makes our University such a gem. #GoBears She is the embodiment of Cal basketball as she doesnt just prepare our players to get better on the court but she helps prepare them for life. - @21charmin Congrats to @epierre4 for making the Top [--] Most Impactful Assistant Coaches List #LevelUp https://t.co/RXS5wNYaiR https://t.co/qfwUCYUOgC She is the embodiment of Cal"  
[X Link](https://x.com/UrnovFyodor/status/1805943508190052531)  2024-06-26T12:37Z 15.4K followers, [----] engagements


"@_andreasborg AAV will continue to be a major driver of progress in genetic medicine. For tissues outside the CNS I believe LNP (or LNP-like) delivery of gene editors will become the dominant delivery mode in the next [--] years. Hence the huge impact of the new Intellia data"  
[X Link](https://x.com/UrnovFyodor/status/1806315400688545797)  2024-06-27T13:15Z 15.2K followers, [---] engagements


"Fellow editors HALP I know someone has taken Dirk's "single step compound het at AAVS1 for two transgenes" approach from the [----] paper - which Danwei has been using for her iCRISPRi system ever since . . and used it on mouse Rosa26. But who"  
[X Link](https://x.com/UrnovFyodor/status/1806319297322688916)  2024-06-27T13:30Z 15.2K followers, [----] engagements


"#Vancouver folks - suggestions for things to do with two [--] yo girls over the next few days (beyond the classics ie Aquarium Capistrano etc). My F1.2 is shown below examining a Totoro cookie (bought at Liberty Bakery on Main St). The cookie did not last long. ❀"  
[X Link](https://x.com/UrnovFyodor/status/1807394812720480633)  2024-06-30T12:44Z 15.3K followers, [----] engagements


"This post of a @springsteen video has absolutely nothing to do with what happened today or that a certain musician from New Jersey had a day declared his by a certain Minnesota governor. https://www.youtube.com/watchv=sWvdFIU6hZg https://www.youtube.com/watchv=sWvdFIU6hZg"  
[X Link](https://x.com/UrnovFyodor/status/1820984431999643679)  2024-08-07T00:44Z 15.4K followers, [----] engagements


"Epigenome editing as a therapeutic. To explain I offer an analogy to musical harmony: whether in Taylor Swift's "Love Story" or Franz Schubert's "Song of Love" it's what makes music sound right. Epiediting aims to restore gene expression harmony. @TIME https://time.com/7009555/7009555/ https://time.com/7009555/7009555/"  
[X Link](https://x.com/UrnovFyodor/status/1822965361555501121)  2024-08-12T11:56Z 15.6K followers, [----] engagements


"@TriggerLoop @paranoiacs That this is their best work is a consensus among beatles obsessives. I agree. It is not my favorite album but it is the best. By far"  
[X Link](https://x.com/UrnovFyodor/status/1823900204040642830)  2024-08-15T01:51Z 15.7K followers, [---] engagements


"The reality-adjusted title of this piece by @adamfeuerstein is: "The Business of One CRISPR Medicine Developed In [----] Using 2009-Style Delivery Is Not Great [--] Months After Its Approval" = a LOT will change in next [--] years https://www.statnews.com/2024/08/15/crispr-therapeutics-vertex-bluebird-bio/ https://www.statnews.com/2024/08/15/crispr-therapeutics-vertex-bluebird-bio/"  
[X Link](https://x.com/UrnovFyodor/status/1824994354009924017)  2024-08-18T02:18Z 15.7K followers, [----] engagements


"Thank YOU @alexmorgan13 for giving my daughter - along with millions of others - a reason to want to be #13 on her soccer team. πŸ™πŸ™πŸ™ #GoBears Thank you🫢 https://t.co/8BkofVOh3s Thank you🫢 https://t.co/8BkofVOh3s"  
[X Link](https://x.com/UrnovFyodor/status/1832947575521259641)  2024-09-09T01:02Z 15.7K followers, [----] engagements


"Today is an apt one to honor Joan Pontius a Cat Lady par excellence whose leadership of this effort gave my field of Genetics a uniquely valuable teaching and scholarship resource. #WomenInSTEM H/t @taylorswift13 for the inspiration to post this. https://genome.cshlp.org/content/17/11/1675.long https://genome.cshlp.org/content/17/11/1675.long"  
[X Link](https://x.com/UrnovFyodor/status/1833942836842234197)  2024-09-11T18:56Z 15.7K followers, [---] engagements


"Sector fundamentals in clinical gene editing are at an all time high and rising. Also rising: investor short-termism forcing editing biotechs (Intellia Beam Caribou Chroma Tome) into layoffs. Nonprofits/academia must keep the flame burning bright. https://endpts.com/arbor-cuts-early-stage-discovery-work-lays-off-staff/ https://endpts.com/arbor-cuts-early-stage-discovery-work-lays-off-staff/"  
[X Link](https://x.com/UrnovFyodor/status/1835059878119059935)  2024-09-14T20:55Z 15.7K followers, [----] engagements


"Public editing biotechs seldom share regulatory learnings. The NIH SCGE @somaticediting brought together a School-of-Athens gathering of IND-headed academic groups. We learned from each other's CBER interactions to rise together and accelerate CRISPR to clinic. #epluribusunum"  
[X Link](https://x.com/UrnovFyodor/status/1836404776826998905)  2024-09-18T13:59Z 15.7K followers, [---] engagements


"I think @adamfeuersteins arguments are a strong argument for why nonviral gene editing has to become a wider clinical reality sooner. This is not utopia - this is reality-infused optimism. πŸ€“ Gene therapy for sickle cell disease remains a tough business model and may never work @adamfeuerstein writes. https://t.co/bupODm4eyJ Gene therapy for sickle cell disease remains a tough business model and may never work @adamfeuerstein writes. https://t.co/bupODm4eyJ"  
[X Link](https://x.com/UrnovFyodor/status/1839449579919708599)  2024-09-26T23:38Z 15.7K followers, [----] engagements


"The bad ("thank you" investor short-termism): @PrimeMedicine cuts its pipeline like all the other for-profit editing biotechs have. The good (THANK YOU Peter Marks): Prime's smart focus on the "CRISPR as a platform" way to make medicines. @Jasonmmast https://www.statnews.com/2024/09/30/prime-medicine-david-liu-gene-editing-cutbacks-bristol-myers-squibb/ https://www.statnews.com/2024/09/30/prime-medicine-david-liu-gene-editing-cutbacks-bristol-myers-squibb/"  
[X Link](https://x.com/UrnovFyodor/status/1840718996267806951)  2024-09-30T11:43Z 15.7K followers, [----] engagements


"Jason is correct. Note that what is happening to the pipelines of Prime Medicine or Beam Therapeutics or any other editing biotech has _nothing_ to do with how robust and versatile the underlying technologies are. All are clinic-grade and can support huge pipelines. @drrichjlaw @ADeAngelis_bio And that matters societally but also for the scale and timeline of a company that came out with some pretty sweeping ambitions @drrichjlaw @ADeAngelis_bio And that matters societally but also for the scale and timeline of a company that came out with some pretty sweeping ambitions"  
[X Link](https://x.com/UrnovFyodor/status/1841209726073520239)  2024-10-01T20:13Z 15.7K followers, 12.7K engagements


"Epistasis - a lovely Greek-origin word that frightens undergraduates in Genetics. No longer. The first gene editing medicine Casgevy works by targeting an epistatic suppressor of the disease-causing gene. Here in HD a small molecule does same. https://endpts.com/loqus23-bags-43m-in-series-a-to-move-huntingtons-drug-into-first-human-study/ https://endpts.com/loqus23-bags-43m-in-series-a-to-move-huntingtons-drug-into-first-human-study/"  
[X Link](https://x.com/UrnovFyodor/status/1841506243673989439)  2024-10-02T15:51Z 15.6K followers, [----] engagements


"If everyone who thinks David Baker is amazing having collaborated with him and enjoyed it tremendously because he's just epic - were to post something about that on this site . it would crash the server. So I won't. . wait a minute. :-) https://newsroom.uw.edu/news-releases/biochemist-david-baker-receives-nobel-prizeutm_source=uwhp&utm_medium=tiles&utm_campaign=david-baker-nobel-prize-announcement https://newsroom.uw.edu/news-releases/biochemist-david-baker-receives-nobel-prizeutm_source=uwhp&utm_medium=tiles&utm_campaign=david-baker-nobel-prize-announcement"  
[X Link](https://x.com/UrnovFyodor/status/1843992872200356346)  2024-10-09T12:32Z 15.7K followers, [----] engagements


""Investor impatience" I can't even More gene editing layoffs Investors showing little patience for the field particularly new companies trying to find ways of inserting whole genes into patients https://t.co/1loXSWfD3D More gene editing layoffs Investors showing little patience for the field particularly new companies trying to find ways of inserting whole genes into patients https://t.co/1loXSWfD3D"  
[X Link](https://x.com/UrnovFyodor/status/1845780294730977510)  2024-10-14T10:54Z 15.7K followers, [----] engagements


"This is why I read @statnews every morning. Where else can you find a quote from a biotech investor that is so magnificently self-incriminating wrt the pathological - and poisonous - short-termism in that community of people πŸ™@ADeAngelis_bio"  
[X Link](https://x.com/UrnovFyodor/status/1846156411606090215)  2024-10-15T11:49Z 15.6K followers, [----] engagements


"@aedwards02 @statnews @ADeAngelis_bio Aaron and I in turn can't tell you how sorry I am you - along with our entire sector - have to deal with this"  
[X Link](https://x.com/UrnovFyodor/status/1846169289315041606)  2024-10-15T12:40Z 15.7K followers, [---] engagements


"I met Prime Minister Cameron at a visit to the UK recently. His family's story of living with genetic disease is deeply affecting - and his vision and drive towards enabling disruptive change in developing genetic medicines for N=rare is timely and compelling. As a father I know all too well the impact of rare diseases. The steps were taking now means that soon families like mine will have hope. The mission of the @OHRareDisease Centre to develop new treatments for rare diseases is hugely ambitious but this is the right time the https://t.co/74KbF8gxvI As a father I know all too well the"  
[X Link](https://x.com/UrnovFyodor/status/1846512176770822631)  2024-10-16T11:23Z 15.6K followers, [----] engagements


""Chuffed" is what contestants on the Great British Baking Show say when Paul Hollywood gives them the famous Handshake. I think it means - "thrilled beyond words." β™₯ Jennifer Doudna offers The @NewYorker her top [--] #CRISPR books to understand the gene-editing revolution: CRISPR People by @HankGreelyLSJU; The Codebreaker by @WalterIsaacson; and my own Editing Humanity Im so chuffed https://t.co/SeBGHbvpZg Jennifer Doudna offers The @NewYorker her top [--] #CRISPR books to understand the gene-editing revolution: CRISPR People by @HankGreelyLSJU; The Codebreaker by @WalterIsaacson; and my own"  
[X Link](https://x.com/UrnovFyodor/status/1846924788314657231)  2024-10-17T14:42Z 15.7K followers, [----] engagements


"The chief vendor and proponent of this snake oil - Jonathan Anomaly - has zero education in Genetics. I checked. This is like someone with zero experience in structural engineering - selling earthquake-resistant houses. https://www.theguardian.com/science/2024/oct/18/us-startup-charging-couples-to-screen-embryos-for-iq https://www.theguardian.com/science/2024/oct/18/us-startup-charging-couples-to-screen-embryos-for-iq"  
[X Link](https://x.com/UrnovFyodor/status/1847756053121028307)  2024-10-19T21:45Z 16.1K followers, [----] engagements


"The off-target analysis Vertex did for Casgevy the first approved CRISPR medicine is public information - and is exemplary. Gr9 (98) choice @statnews @MeganMolteni https://www.statnews.com/meet-the-2024-stat-wunderkinds/zach-zappala/ https://www.statnews.com/meet-the-2024-stat-wunderkinds/zach-zappala/"  
[X Link](https://x.com/UrnovFyodor/status/1849815754612646008)  2024-10-25T14:10Z 16.1K followers, [----] engagements


"Recent public statements claimed immigrants with "bad genes" are "poisoning the blood of our country." As an immigrant and a human being I take this personally. As a professor of Genetics I teach that this is nonscientific dung - see my lecture (2004): https://www.dropbox.com/scl/fi/x2vbfltevjs6nn1j7sknc/Genetics-of-IQ-Fyodor-Urnov-lecture-Dec-2004-MCB140-UC-Berkeley.pdfrlkey=ikn3gowtfxxelzsy4ks09mctz&dl=0 https://www.dropbox.com/scl/fi/x2vbfltevjs6nn1j7sknc/Genetics-of-IQ-Fyodor-Urnov-lecture-Dec-2004-MCB140-UC-Berkeley.pdfrlkey=ikn3gowtfxxelzsy4ks09mctz&dl=0"  
[X Link](https://x.com/UrnovFyodor/status/1851320196692140425)  2024-10-29T17:48Z 16.1K followers, [----] engagements


"This is tragic and the only words are - other than mourn - to learn as much as we can about what happened to honor the memory of this brave person who volunteered to be on the trial - and make the therapy safer moving forward. Patient dies in Beam Therapeutics trial of CRISPR sickle cell treatment https://t.co/i3Mqj4hRtC via @statnews Patient dies in Beam Therapeutics trial of CRISPR sickle cell treatment https://t.co/i3Mqj4hRtC via @statnews"  
[X Link](https://x.com/UrnovFyodor/status/1853799044310843887)  2024-11-05T13:58Z 15.7K followers, [----] engagements


"#CRISPR cures on-demand can and will be scaled nationwide. In this talk at the Oxford-Harrington symposium I argue - with data - that the first nation to do so will be the United Kingdom and describe an actionable path to that goal. https://youtu.be/qlzhcYh7cLMsi=1mM52JOBsMeHPCZg https://youtu.be/qlzhcYh7cLMsi=1mM52JOBsMeHPCZg"  
[X Link](https://x.com/UrnovFyodor/status/1855971807846973472)  2024-11-11T13:52Z 15.6K followers, [----] engagements


"Interested in #CRISPR-based gene editing therapies This symposium is for you It'll cover the full "target discovery to clinic" journey in talks by SMEs from academia+ industry. Room left for late abstract-based presentations (submit by Dec 5) Pls RT πŸ™ https://www.keystonesymposia.org/conferences/conference-listing/meeting/C12025 https://www.keystonesymposia.org/conferences/conference-listing/meeting/C12025"  
[X Link](https://x.com/UrnovFyodor/status/1862933330381209862)  2024-11-30T18:54Z 15.6K followers, [----] engagements


"Dr Peter Marks (head of FDA CBER) makes an apt analogy between #CRISPR and razors in this @NPR @robsteinnews piece about work we are doing at the @igisci @UCBerkeley to expand the clinical footprint of gene editing to children with "N=1" gene mutations. https://www.npr.org/2024/12/03/nx-s1-5090880/customized-crispr-treatments-could-help-people-with-rare-genetic-disorders https://www.npr.org/2024/12/03/nx-s1-5090880/customized-crispr-treatments-could-help-people-with-rare-genetic-disorders"  
[X Link](https://x.com/UrnovFyodor/status/1864283620753723871)  2024-12-04T12:20Z 15.6K followers, [----] engagements


"Painful and sobering news. My heart breaks for my fellow editors. Also a loss for patients. Our sector needs a new model - it will come out of innovative partnerships between academia nonprofit and industry. Editas Medicine lays off 65% of staff and shelves lead gene-editing program https://t.co/tNWrOXdhUW via @statnews Editas Medicine lays off 65% of staff and shelves lead gene-editing program https://t.co/tNWrOXdhUW via @statnews"  
[X Link](https://x.com/UrnovFyodor/status/1867344352433086620)  2024-12-12T23:02Z 15.7K followers, 13.6K engagements


""At the end of every hard-earned day People find a reason to believe" (Springsteen) Watch this video. It's data-based reason to believe. Don't forget Kleenex. I watched this video [--] times and cried every single time. 10-month-old KJ Muldoon who landed in international headlines after receiving a first-of-its-kind gene-editing treatment was released from the hospital last week. The bespoke therapy was developed by @kiranmusunuru & Dr. Rebecca Ahrens-Nicklas. https://t.co/m5PCsMtFtd 10-month-old KJ Muldoon who landed in international headlines after receiving a first-of-its-kind gene-editing"  
[X Link](https://x.com/UrnovFyodor/status/1932187832115966086)  2025-06-09T21:27Z 15.7K followers, [----] engagements

Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing

@UrnovFyodor Avatar @UrnovFyodor Fyodor Urnov

Fyodor Urnov posts on X about vivo, investment, beam, tide the most. They currently have [------] followers and [---] posts still getting attention that total [--] engagements in the last [--] hours.

Engagements: undefined #

Engagements Line Chart

  • [--] Months [--] -100%
  • [--] Year [-----] -97%

Mentions: undefined #

Mentions Line Chart

Followers: [------] #

Followers Line Chart

  • [--] Month [------] +18%
  • [--] Months [------] +40%
  • [--] Year [------] +43%

CreatorRank: undefined #

CreatorRank Line Chart

Social Influence

Social category influence finance 9.9% technology brands 5.94% celebrities 3.96% stocks 3.96% countries 3.96% ncaa football 3.96% musicians 1.98% travel destinations 1.98% automotive brands 0.99% currencies 0.99%

Social topic influence vivo 3.96%, investment 2.97%, beam 2.97%, tide 1.98%, india 1.98%, money 1.98%, have the 0.99%, products 0.99%, target 0.99%, if you 0.99%

Top accounts mentioned or mentioned by @igisci @statnews @adeangelisbio @danahercorp @bradloncar @pennmedicine @kiranmusunuru @adamfeuerstein @ucberkeley @johndoench @editasmed @naturebiotech @intelliatx @hoperhenderson @nature @meganmolteni @geneinvesting @jasonmmast @matthewherper @stjuderesearch

Top assets mentioned BEAM (BEAM) AbbVie Inc (ABBV) MAYA (MAYA) Goldman Sachs (GS) Intellia Therapeutics, Inc (NTLA) Alphabet Inc Class A (GOOGL) Euler (EUL) Pfizer, Inc. (PFE) GARY (GARY) Enzyme (MLN) Harmony (ONE) Optimism (OP) Handshake (HNS)

Top Social Posts

Top posts by engagements in the last [--] hours

"@bradloncar Mmmm Fate (and Allogene and Sangamo Cellectis Caribou Editas Intellia CRISPR Beam) have the entire editing toolbox they can use to make their product(s) better if they want to. And the entire genome as a potential target"
X Link 2021-08-20T13:50Z 22.4K followers, [--] engagements

"I have zero street cred in threads - but the TIDE analysis Synthego provides is rock-solid and consistently useful and has near-no learning curve (in terms of enabling folks who are not professional editors to get their data)"
X Link 2023-07-10T17:14Z 13.9K followers, [----] engagements

"Dr Shondra Miller the PI for this newly opened position is the gene editing version of Captain Marvel. If you think this is hyperbole ask anyone who has actually worked with her. AND @StJudeResearch hosts some of THE best gene editors in our field"
X Link 2023-08-22T20:34Z 13.9K followers, [---] engagements

"Expanding the public health impact of CRISPR to address N=1/rare disease will require scientists in industry and in academia to collaborate and jointly become "the rising tide that lifts all boats." Here's a gr9 (98) example"
X Link 2023-08-29T19:50Z 13.8K followers, [---] engagements

"20000 persons have received CAR-T / TCR-T therapy thanks to the skill and courage of the @PennMedicine team led by Carl June to initial curative outcomes. Carl and colleagues did the first clinical trial for genome editing - paving the way for the Age of CRISPR in the Clinic"
X Link 2023-09-15T11:27Z 13.8K followers, [----] engagements

"The path through this to #HealthJustice: [--]. Editing vs gene therapy. [--]. In vivo vs ex vivo. Both WILL happen. Sole issue: pricing ex-US (in US in vivo editing will still be [--] figures despite 4-figure COGs). Superb piece @DrewQJoseph https://www.statnews.com/2023/10/04/gene-therapy-makers-wonder-if-they-can-make-a-profit-in-europe-patients-fear-being-left-behind-again/ https://www.statnews.com/2023/10/04/gene-therapy-makers-wonder-if-they-can-make-a-profit-in-europe-patients-fear-being-left-behind-again/"
X Link 2023-10-04T12:42Z 15.7K followers, [----] engagements

"A huge step for Intellia and a bigger one for the field of editing the human liver: as I learned from @kiranmusunuru there are [----] newborns in the US with editable inborn errors of immunity. A majority could be edited to health one-and-done in this way"
X Link 2023-10-18T13:19Z 13.5K followers, [----] engagements

"1. Base editing is a powerful + flexible technology for clinic-grade repair of mutations leveraged into ex vivo + in vivo approaches. [--]. Team Beam is SUPERB. = a glaring example imho of the disconnect between The Street's take and sector fundamentals"
X Link 2023-10-19T18:16Z 13.5K followers, 11.2K engagements

"@JustinAPater @JohnDoench @nathanwpyle @dccc_phd I think there is some conspiracy around DD. What other explanation is there Here is a Seattle roadmap for anyone from Beantown who seeks [--] separate examples of The Truth. Which is out there. (fwiw to me Vivace is Messi and Vita is Bonham on drums)"
X Link 2023-10-31T22:17Z 13.6K followers, [--] engagements

"BRAVO @editasmed - what a class act To all the zero-sum-gamers out there who think life is MMA tragically glued to your puerile Weltanschauung of "who will win" - learn from this: one biotech congratulating another in a field where they are allegedly direct competitors"
X Link 2023-11-16T15:28Z 13.7K followers, 14.3K engagements

"@NKWhiteman Quoting Denzel Washington from Philadelphia: explain it to me like I am a [--] year old. What specific method of preparing coffee retains the most terpenoids in the resulting coffee"
X Link 2023-11-21T20:56Z 13.8K followers, [----] engagements

""Monetization of existing content" is the trend @apcbapcb is concerned by - as if McCartney is Abbvie milking the patent system for Humira It's not an either/or with originality: listen to @mashupmartin genius remix of Revolver"
X Link 2023-11-26T13:30Z 13.8K followers, [---] engagements

"Casgevy is a landmark for genetic medicine and for gene editing (CoI disclosure below). And yet market forces have shrunk active pipelines of [--] leading gene editing biotechs to [--] diseases. CRISPR can be curative. We cannot lose that momentum"
X Link 2023-12-04T22:18Z 13.8K followers, [----] engagements

""Ive escaped from the clutch of fear that comes from thinking every occasion could be my last." Oh my heart. THIS folks is what CRISPR can do. THIS is why we MUST expand its public health footprint"
X Link 2023-12-04T23:00Z 13.8K followers, [----] engagements

"$ CoI disclosure: I am a paid consultant to Vertex Pharmaceuticals on the exa-cel program"
X Link 2023-12-04T23:00Z 13.8K followers, [---] engagements

"Hear hear Go MTx I look slightly insane here because the news of Casgevy approval broke [--] min before this photograph was taken and Jennifer was LITERALLY the first person I ran into at the retreat; in this picture quoting Dua Lipa I'm levitating"
X Link 2023-12-09T16:47Z 13.9K followers, [----] engagements

"1. What does Casgevy mean for gene editors [--]. What is next on the #CRISPR cures horizon [--]. Will base/prime editing supplant classical editing. [--]. What is @igisci up to What a treat to meet @bradloncar - a sane and sage mind - in person. Brad is every bit the real deal"
X Link 2023-12-13T23:34Z 14K followers, 16.6K engagements

"@sciliz @pknoepfler I wasn't aware of this. In the eloquent words of Bob Seeger: "Wish I didn't know now what I didn't know then" Cults have been with humankind for the entirety of its recorded history. The cult of anti-GMO - commercialized by vendors peddling "safer" non-GMO food - harms the world"
X Link 2023-12-15T18:39Z 14K followers, [--] engagements

"@adamfeuerstein Holy [--] Mole-y. Your analogy to a pawn shop is pitch-perfect then. WOW"
X Link 2023-12-18T22:31Z 13.8K followers, [---] engagements

"This is an outrage and a profound injustice. The @igisci @DanaherCorp Beacon for CRISPR Cures is not run by the naive - we are all realists and veterans of developing gene editing medicines in the real world. We are confident in our ability to develop and deliver for all to use a scalable portable affordable approach to develop and provide gene editing medicines for neurologic diseases treatable by repairing blood stem cells - such as the one this child is suffering from. #HealthJustice"
X Link 2024-01-09T18:23Z 13.5K followers, [----] engagements

"Genetic disease knows no borders. Neither should #CRISPR cures. Essential reading by @drbenjohnson @NatureBiotech . showcasing the #yeswecan approach to providing gene therapy cures in India Brazil Thailand and beyond. A key goal of the @igisci @DanaherCorp Beacon for CRISPR Cures is to have gene editing follow that example and build Platform approaches to make such cures affordable manufacturable and deliverable to patients where the unmet medical need is and not just where the current GMP suites are. #HealthJustice"
X Link 2024-01-15T16:36Z 13.9K followers, [----] engagements

"The @igisci @DanaherCorp Beacon for CRISPR Cures seeks: . to build+take to clinic two gene editing medicines for severely ill children. . a talented project manager to work with an amazing team in making that happen. Link to job posting below - pls RT"
X Link 2024-01-16T23:31Z 13.6K followers, [----] engagements

"Something tells me US-approved biosimilars for gene therapies will not fare better. For gene editing in "rare" disease - we need to and will get to a world where the COGs of developing and administering a dose of nonviral #CRISPR is $200k"
X Link 2024-01-17T22:18Z 14.2K followers, [----] engagements

"Gr9 (98) ball movement and gr9 touch from downtown. @KemeryM #GoBears 3rd time's the charm πŸ€ @KemeryM https://t.co/SHzXOSDxVM 3rd time's the charm πŸ€ @KemeryM https://t.co/SHzXOSDxVM"
X Link 2024-01-21T21:04Z [--] followers, [----] engagements

"Duck season πŸ€£πŸ‘πŸ»πŸ’― #GoBears"
X Link 2024-01-21T21:59Z 13.9K followers, [--] engagements

"#CRISPR is a platform for cures. @intelliatx describes a second "nothing but net" clinical dataset on liver editing that technologically is a copy-paste of an earlier such effort (34215024) in a different disease. Only the guide RNA is different. We HAVE to expand this platform to treat 1000s of newborns with severe metabolic disease (h/t @kiranmusunuru) who can be cured using this approach. At the present time no for-profit biotech will take this on. Intellia - who has absolutely best-in-class editing data - had to lay off staff (). This is where the academic/nonprofit sector comes in."
X Link 2024-02-02T16:26Z 14.3K followers, [----] engagements

"@_WhitneyLauren @scifri This is THE issue. I will post some key publications coming out from the @igisci on this topic and tag you when I do so - this will happen in the next [--] weeks. Thank you VERY much for bringing this up"
X Link 2024-02-03T11:41Z 14.3K followers, [---] engagements

"Leave. Tracy. Chapman. ALONE. @sisario @hknightsf Her oeuvre is without rival in popular music in its beauty sincerity humanity and everlasting relevance. She gave her heart and soul to it. She has a right to be as private as she wants. I come to the city a lot and if I see her despite wanting to fall down on both knees before her I will respect her privacy. Everyone should do same. #TracyChapman"
X Link 2024-02-07T00:46Z 14.3K followers, [---] engagements

"@hoperhenderson The Life You Save May Be Your Own The Maya Hawke film about her is superb. Wildcat"
X Link 2024-02-12T02:03Z 14.3K followers, [---] engagements

"@hoperhenderson The iconic A Good Man Is Hard to Find is absolutely sui generis of course"
X Link 2024-02-12T02:05Z 14.4K followers, [---] engagements

".@marilenharo Thank you for covering newer technologies in genetic medicine space. "Move over CRISPR" Please refrain from zero-sum-game-ism. This is the realm of some in the investment community (vide infra) but is below the dignity of @nature"
X Link 2024-02-19T02:17Z 14.4K followers, [----] engagements

"There is goodness in in our troubled world. There IS. Exhibit 1A: work led @UCSF by Dr. Tippi MacKenzie @MackenzieTippi to use #CRISPR and treat severe genetic disease before it does irreversible harm. Inspiring reporting by @MeganMolteni @statnews"
X Link 2024-02-21T13:21Z 14.5K followers, [----] engagements

"A glaring example of why the academic/nonprofit sector has to take a larger role in #CRISPR N=rare cures. @intelliatx has THE best clinical data in the entire field. AND a platform to build more. = this Goldman Sachs "slasher" is a random number generator. H/t @GeneInvesting $NTLA Goldman Sachs slashes Intellia Therapeutics price target to $32 from $136 downgrades to Neutral from Buy; Canaccord Genuity raises target to $73 from $72 Buy rating. $NTLA Goldman Sachs slashes Intellia Therapeutics price target to $32 from $136 downgrades to Neutral from Buy; Canaccord Genuity raises target to $73"
X Link 2024-02-24T19:46Z 14.6K followers, 45.4K engagements

"This is NOT investment advice. I am an SME in the technology (gene editing) and how to put it into the clinic and what the unmet need is and what the broader range of impact of specific technologies in this space is"
X Link 2024-02-24T19:46Z 14.5K followers, [----] engagements

""Estamos tocando tiki-taka tiki-taka" [--] years after the above was said for the first time the supreme practitioners of this magical style are in prime form. #Messi Messi πŸ”— Alba WHAT A GOAL https://t.co/LuYpsiAb2X Messi πŸ”— Alba WHAT A GOAL https://t.co/LuYpsiAb2X"
X Link 2024-02-26T18:01Z 14.5K followers, [----] engagements

"@asparks1010100 @NatureBiotech Rule [--] of my field is never ever give families false hope. With that. [--]. The US Federal Government has funded a Navy Seal Team 6-grade constellation of gene editors and physicians to develop a gene editing treatment for PKU. [--]. Tessera is working on this as well. 1+2=progress"
X Link 2024-02-27T16:57Z 14.5K followers, [--] engagements

"@NatPress @Stanford @igisci I admire the scientists and physicians who make @stanford one of the gems in the constellation of research universities. With that. I am a professor at @UCBerkeley where the @igisci is and from which we welcome our friends in Palo Alto to learn from us as much as they need to"
X Link 2024-02-29T16:05Z 14.5K followers, [---] engagements

"Well folks if Google - which built its $1.7 trillion market cap on analysis of data - makes this mistake . this is an actual screen cap of an autocorrect gmail suggested for an e-mail I was writing ChatGPT [--] - next tweet - is taking both sides. Words - other than "data" - fail me"
X Link 2024-03-04T15:23Z 14.6K followers, [----] engagements

"Neither the film #Oppenheimer nor this @Nature piece . about its science has ANY substantive discussion about what surely is the only issue that matters: a group of brilliant scientists designed and had built a horrific weapon of civilian mass murder. How did they FEEL about that How do physicists feel about it NOW The goal is not to assign blame - but to assign meaning to this devastating intersection between fundamental science and the real world"
X Link 2024-03-11T14:32Z 14.6K followers, [----] engagements

"More short-termist lemmingage (lemmingism) from the Street. The fundamentals here are VERY strong. = yet more reasons why the academic/nonprofit sector is stepping up to the plate on CRISPR cures. Caribou reaction to earnings makes little sense to me or anyone. Progressing [--] programs [--] of which show data this year and burning VERY little compared to other companies. Only negative is pausing CB-020 hard to imagine shelving ONE very early non-clinical program is worth Caribou reaction to earnings makes little sense to me or anyone. Progressing [--] programs [--] of which show data this year and"
X Link 2024-03-12T15:52Z 14.6K followers, [----] engagements

"A superb read from @Jasonmmast on the "last mile" problem in gene therapy - how to get an approved medicine to a patient. Building the cure does not equal curing someone in the real world folks. #VerticalIntegrationIsAMust Hemophilia gene therapies arrived after [--] years of struggle. Where are the patients https://t.co/SZW1fhv8dL Hemophilia gene therapies arrived after [--] years of struggle. Where are the patients https://t.co/SZW1fhv8dL"
X Link 2024-03-13T14:23Z 15.5K followers, [----] engagements

"It's Sunday and this one is for @JohnDoench. I would like to change all my social media handles and userids to: BornToTunAGel What are your thoughts"
X Link 2024-03-17T22:28Z 14.6K followers, [----] engagements

".@aurmanARK's pithy prcis of a key challenge for our field @statnews summit: How does a curative therapy command the pricing that it needs to command in order for investors to get back their money but also get it to people that need it most"
X Link 2024-03-22T23:59Z 14.6K followers, [----] engagements

"It's late Sunday morning. Trivia time. I just learned that Sudoku was invented by Euler in the mid-18th century. Euler also invented the f(x) notation. And in passim Euler's identity"
X Link 2024-03-24T16:31Z 14.7K followers, [----] engagements

"Re a transient SAE on a gene editing trial. Reminder: Back in 2012: The first CAR-T patient Emily Whitehead was within [--] hrs of dying from a never before seen SAE. The clinicians course-adjusted. 2024: CAR-T - [-----] patients treated with [--] commercial products"
X Link 2024-04-02T11:38Z 14.7K followers, [----] engagements

"@LukashPlatil Could you explain what a "debt stack" is πŸ™"
X Link 2024-04-05T12:50Z 15K followers, [--] engagements

"Critically ill newborns in Northern India diagnosed w genetic disease by rapid sequencing. We WILL have a world where blood and liver disease in such children will be #CRISPR editable within [--] months at a COGs $10k. ALL the technologies exist NOW. https://www.nature.com/articles/s41431-024-01569-z https://www.nature.com/articles/s41431-024-01569-z"
X Link 2024-04-12T15:09Z 14.7K followers, 38K engagements

"The curative potential of #CRISPR gene editing has been established - yet pipelines of for-profit editing biotechs have shrunk. I appreciate the @asgct for the opportunity to share the podium with fellow SMEs in editing and speak with federal legislators about real-world change required here. #Geneediting has the potential to transform treatment for #rarediseases. A recent Capitol Hill briefing introduced congressional staffers to the underlying science of gene editing + considerations for patients. Watch now. https://t.co/za3YAvSVWR #ASGCTadvocacy #Geneediting has the potential to transform"
X Link 2024-04-16T15:04Z 14.7K followers, [----] engagements

"Lubert Stryer passed away - his name never will. His Well Tempered Clavier of a textbook came out in the USSR in [----]. I started college in [----] and slept with it under my pillow. I very nearly brought it with me to the USA when I emigrated in [----]. #CoalsToNewcastle"
X Link 2024-04-16T15:44Z 14.7K followers, [----] engagements

"@matthewherper Hear hear. If in Vienna go see this. It does not travel for some reason (eg it was not in the recent pan-Vermeer show in Amsterdam). https://en.wikipedia.org/wiki/The_Art_of_Painting https://en.wikipedia.org/wiki/The_Art_of_Painting"
X Link 2024-04-18T12:17Z 14.7K followers, [---] engagements

"Imagine combining: [--] - 23andMe data on folks who "have" genetic disease - but not clinically (v.i.) [--] - CRISPR to map protective variants [--] - making them in the clinic la Casgevy All the technologies exist. Just not inside 23andMe. @ADeAngelis_bio https://www.statnews.com/2024/04/18/23andme-anne-wojcicki-moves-to-take-company-private/ https://www.statnews.com/2024/04/18/23andme-anne-wojcicki-moves-to-take-company-private/"
X Link 2024-04-21T18:50Z 14.7K followers, [----] engagements

"@matthewherper @ADeAngelis_bio I think technology companies tend to have canalized worldviews. They think if they solved for step B then steps A and C-Z will magically happen. In this case they needed an Avengers-like vertical integration of capabilities and to bring Goldilocks partners in. Eg KSQ and Prime"
X Link 2024-04-21T19:45Z 14.7K followers, [---] engagements

"What actually happened: AI produced CRISPR-inspired genome editors that have modest on-target activity in human cancer cells. Impact on actual clinical editing in next [--] years: none. Long term - I sure hope so. I think X needs better AI to write these "Explore" blurbs. :-)"
X Link 2024-04-22T23:00Z 14.8K followers, [----] engagements

"I admire @Regeneron for its commitment to gene-edited therapies. Earlier bringing in [---] and Philip Gregory a superstar to run edited CAR-T programs - now bringing in Team @mammothbiosci - quite a constellation of shining stars themselves 1+2=7 synergy there. We look forward to working with @Regeneron to enable all-in-one AAV delivery and unlock the true potential of in vivo gene editing. Read our press release to learn more: https://t.co/RGyzFq7LhI @doudna_lab @UCBerkeley https://t.co/jFzNtpfjYr We look forward to working with @Regeneron to enable all-in-one AAV delivery and unlock the true"
X Link 2024-04-25T13:29Z 14.8K followers, [----] engagements

"Pfizer is commercializing this therapy. It was developed by Spark Therapeutics under the leadership of Dr Katherine High @PennMedicine. She also built Luxturna - the first approved AAV medicine. Dr High is a hero and inspiration to all working in our field. #WomenInSTEM Pfizers first gene therapy a $3.5 million one-time treatment for hemophilia B enters a market that has vexed other drugmakers https://t.co/QHoNnOuIqs $pfe Pfizers first gene therapy a $3.5 million one-time treatment for hemophilia B enters a market that has vexed other drugmakers https://t.co/QHoNnOuIqs $pfe"
X Link 2024-04-26T17:14Z 14.9K followers, [----] engagements

"@anandcpatelmdms @PennMedicine Mm No disagreement on anything there. I could not find her name mentioned in any of the PR I read - and wanted to remedy that in my own small way"
X Link 2024-04-27T12:02Z 14.8K followers, [---] engagements

"CRISPR medicine #1 - change just the guide RNA spacer (20 nt) keep all else the same - CRISPR medicine #2. Intellia has done this (TTR-HAE). πŸ‘ PJ Brooks πŸ™πŸ™πŸ™is the lead architect of a federal program to do this. #yeswecan H/t @AAMortazavi https://www.cgtlive.com/view/nih-strategizes-to-streamline-gene-therapy-development https://www.cgtlive.com/view/nih-strategizes-to-streamline-gene-therapy-development"
X Link 2024-05-03T13:14Z 14.9K followers, [----] engagements

"Three subjects dosed with base-edited cells In the words of Bruce Springsteen it's been a long time coming my dear it's been a long time coming but now it's here Gregorspeed Beam Excited to share that we have now completed dosing and successful engraftment of all three sentinel patients in the BEAM-101 BEACON trial for sickle cell disease. Expansion dosing will now proceed with the next dose occurring shortly. https://t.co/xAcXR9umDr Excited to share that we have now completed dosing and successful engraftment of all three sentinel patients in the BEAM-101 BEACON trial for sickle cell"
X Link 2024-05-07T18:51Z 14.9K followers, [----] engagements

"@GeneInvesting @RTLeenay I have a greater bias for this than a Kpop fan for their idol but I am arguing that no matter the modality KO repair TI epi - editing is fundamentally distinct from absolutely everything else in the field (RNAi ASO AAV lenti). And the difference makes a difference"
X Link 2024-05-07T21:05Z 14.9K followers, [---] engagements

"Encouraging words from Kimberly Powell (VP Heathcare Nvidia) @statnews #statbreakthrough: AI will accelerate path to N=1/rare medicines"
X Link 2024-05-16T16:48Z 14.9K followers, [----] engagements

"I would not be eligible for a picomole of this award without @berkeleyMCB PhD graduate Michael Holmes who co-developed the genome editing toolbox and @UCBerkeley's own Johann Gutenberg Dr Jennifer Doudna who invented the cognate of the printing press in gene editing. Fiat Lux Congrats to MCB's Fyodor Urnov @UrnovFyodor on being awarded the Horace Mann Medal from @BrownGradSchool πŸ‘πŸŽ‰ https://t.co/efwWdCZZGQ Congrats to MCB's Fyodor Urnov @UrnovFyodor on being awarded the Horace Mann Medal from @BrownGradSchool πŸ‘πŸŽ‰ https://t.co/efwWdCZZGQ"
X Link 2024-05-21T12:30Z 15K followers, [----] engagements

"It speaks sad volumes to the investment climate in gene editing when scientific talks at a scientific meeting by scientists at for-profit companies are . not science talks. They are investor pitch decks. My heart goes out to all my fellow scientists in this unjust predicament"
X Link 2024-05-31T18:03Z 15K followers, [----] engagements

"A path to platform #CRISPR cures is here - fragmented across universities biotechs and CDMOs. How do we weave a curative quilt out of the disconnected bits and pieces πŸ™πŸ™πŸ™ @ElliotHershberg for a thoughtful and clear answer in https://centuryofbio.com/p/scaling-crispr-cures http://centuryofbio.com https://centuryofbio.com/p/scaling-crispr-cures http://centuryofbio.com"
X Link 2024-06-04T11:52Z 15.1K followers, [----] engagements

"The Horace Mann lecture I gave @BrownUniversity has a [--] min subunit - ca 49m30s-56m30s - that distills the vision for gene editing as a platform to build medicines for genetic disease - the goal for the @igisci @DanaherCorp Beacon for CRISPR Cures. https://youtu.be/yhQ_paaNw9csi=jNagCj-9iOR3uIbl https://youtu.be/yhQ_paaNw9csi=jNagCj-9iOR3uIbl"
X Link 2024-06-06T01:59Z 15.1K followers, [----] engagements

"The full lecture gave me a key opportunity to honor my mentors at Brown Drs Susan Gerbi Art Landy and Ken Miller my postdoctoral mentor Dr Alan Wolffe and my colleagues at Sangamo Philip Gregory Mike Holmes Ed Rebar and Gary Lee. The Horace Mann Medal is theirs too"
X Link 2024-06-06T01:59Z 15.1K followers, [---] engagements

"@MitchellReed09 I appreciate your take. The issue here is I was happy to work with Vertex because I'm an SME in this exact space. So I felt I was contributing to public health (in a small but nonzero way). Let me ask some professional ethicists what the US and global legal standard here is"
X Link 2024-06-14T15:26Z 15.1K followers, [---] engagements

"You could not ask for better data for #CRISPR gene editing in sickle - [--] subjects free of VOCs total Hb 14g/dl 40% HbF. Bravo @editasmed My personal take is we're on a path to [--] approved potent genetic medicines for SCD - Casgevy Lyfgenia and the Editas product. Good morning from #EHA2024 Today we are presenting clinical data from the RUBY trial of reni-cel for the treatment of severe sickle cell disease. Learn more: https://t.co/PtYvEiYFvR #sicklecelldisease #geneediting #biotechnology https://t.co/x29gznm1PJ Good morning from #EHA2024 Today we are presenting clinical data from the RUBY"
X Link 2024-06-15T11:15Z 15.1K followers, [----] engagements

"Editas uses a different RNA-guided editor (the enzyme formerly known as Cpf1 - Cas12a) and a different genetic target (the HBG1/2 promoter) than Casgevy (Cas9 and BCL11A enhancer). [--] - yay growing toolbox of clinical CRISPR [--] - yay editing of regulatory DNA to treat disease"
X Link 2024-06-15T11:15Z 15.1K followers, [---] engagements

"@MarkusElsner1 My direct experience with their Scandinavian cognates is that it has to do with money. They lose their income if their raison dtre no longer exists due to hard data"
X Link 2024-06-15T15:52Z 15.1K followers, [---] engagements

"@natashaloder @bradloncar It's going to be progressive. The lung is currently editable in vivo as is hematopoiesis (also in vivo). Between liver lung and blood - that is an exceptionally large landscape for CRISPR cure deployment (think COPD and IBD)"
X Link 2024-06-26T12:31Z 15.2K followers, [--] engagements

"Coach Eliza @epierre4 is currently coaching a basketball summer camp here on campus for 8-12 yo girls. My [--] yo and her best friend cannot WAIT to return to it. Caring devoted talented and accomplished folks like Coach Eliza are what makes our University such a gem. #GoBears She is the embodiment of Cal basketball as she doesnt just prepare our players to get better on the court but she helps prepare them for life. - @21charmin Congrats to @epierre4 for making the Top [--] Most Impactful Assistant Coaches List #LevelUp https://t.co/RXS5wNYaiR https://t.co/qfwUCYUOgC She is the embodiment of Cal"
X Link 2024-06-26T12:37Z 15.4K followers, [----] engagements

"@_andreasborg AAV will continue to be a major driver of progress in genetic medicine. For tissues outside the CNS I believe LNP (or LNP-like) delivery of gene editors will become the dominant delivery mode in the next [--] years. Hence the huge impact of the new Intellia data"
X Link 2024-06-27T13:15Z 15.2K followers, [---] engagements

"Fellow editors HALP I know someone has taken Dirk's "single step compound het at AAVS1 for two transgenes" approach from the [----] paper - which Danwei has been using for her iCRISPRi system ever since . . and used it on mouse Rosa26. But who"
X Link 2024-06-27T13:30Z 15.2K followers, [----] engagements

"#Vancouver folks - suggestions for things to do with two [--] yo girls over the next few days (beyond the classics ie Aquarium Capistrano etc). My F1.2 is shown below examining a Totoro cookie (bought at Liberty Bakery on Main St). The cookie did not last long. ❀"
X Link 2024-06-30T12:44Z 15.3K followers, [----] engagements

"This post of a @springsteen video has absolutely nothing to do with what happened today or that a certain musician from New Jersey had a day declared his by a certain Minnesota governor. https://www.youtube.com/watchv=sWvdFIU6hZg https://www.youtube.com/watchv=sWvdFIU6hZg"
X Link 2024-08-07T00:44Z 15.4K followers, [----] engagements

"Epigenome editing as a therapeutic. To explain I offer an analogy to musical harmony: whether in Taylor Swift's "Love Story" or Franz Schubert's "Song of Love" it's what makes music sound right. Epiediting aims to restore gene expression harmony. @TIME https://time.com/7009555/7009555/ https://time.com/7009555/7009555/"
X Link 2024-08-12T11:56Z 15.6K followers, [----] engagements

"@TriggerLoop @paranoiacs That this is their best work is a consensus among beatles obsessives. I agree. It is not my favorite album but it is the best. By far"
X Link 2024-08-15T01:51Z 15.7K followers, [---] engagements

"The reality-adjusted title of this piece by @adamfeuerstein is: "The Business of One CRISPR Medicine Developed In [----] Using 2009-Style Delivery Is Not Great [--] Months After Its Approval" = a LOT will change in next [--] years https://www.statnews.com/2024/08/15/crispr-therapeutics-vertex-bluebird-bio/ https://www.statnews.com/2024/08/15/crispr-therapeutics-vertex-bluebird-bio/"
X Link 2024-08-18T02:18Z 15.7K followers, [----] engagements

"Thank YOU @alexmorgan13 for giving my daughter - along with millions of others - a reason to want to be #13 on her soccer team. πŸ™πŸ™πŸ™ #GoBears Thank you🫢 https://t.co/8BkofVOh3s Thank you🫢 https://t.co/8BkofVOh3s"
X Link 2024-09-09T01:02Z 15.7K followers, [----] engagements

"Today is an apt one to honor Joan Pontius a Cat Lady par excellence whose leadership of this effort gave my field of Genetics a uniquely valuable teaching and scholarship resource. #WomenInSTEM H/t @taylorswift13 for the inspiration to post this. https://genome.cshlp.org/content/17/11/1675.long https://genome.cshlp.org/content/17/11/1675.long"
X Link 2024-09-11T18:56Z 15.7K followers, [---] engagements

"Sector fundamentals in clinical gene editing are at an all time high and rising. Also rising: investor short-termism forcing editing biotechs (Intellia Beam Caribou Chroma Tome) into layoffs. Nonprofits/academia must keep the flame burning bright. https://endpts.com/arbor-cuts-early-stage-discovery-work-lays-off-staff/ https://endpts.com/arbor-cuts-early-stage-discovery-work-lays-off-staff/"
X Link 2024-09-14T20:55Z 15.7K followers, [----] engagements

"Public editing biotechs seldom share regulatory learnings. The NIH SCGE @somaticediting brought together a School-of-Athens gathering of IND-headed academic groups. We learned from each other's CBER interactions to rise together and accelerate CRISPR to clinic. #epluribusunum"
X Link 2024-09-18T13:59Z 15.7K followers, [---] engagements

"I think @adamfeuersteins arguments are a strong argument for why nonviral gene editing has to become a wider clinical reality sooner. This is not utopia - this is reality-infused optimism. πŸ€“ Gene therapy for sickle cell disease remains a tough business model and may never work @adamfeuerstein writes. https://t.co/bupODm4eyJ Gene therapy for sickle cell disease remains a tough business model and may never work @adamfeuerstein writes. https://t.co/bupODm4eyJ"
X Link 2024-09-26T23:38Z 15.7K followers, [----] engagements

"The bad ("thank you" investor short-termism): @PrimeMedicine cuts its pipeline like all the other for-profit editing biotechs have. The good (THANK YOU Peter Marks): Prime's smart focus on the "CRISPR as a platform" way to make medicines. @Jasonmmast https://www.statnews.com/2024/09/30/prime-medicine-david-liu-gene-editing-cutbacks-bristol-myers-squibb/ https://www.statnews.com/2024/09/30/prime-medicine-david-liu-gene-editing-cutbacks-bristol-myers-squibb/"
X Link 2024-09-30T11:43Z 15.7K followers, [----] engagements

"Jason is correct. Note that what is happening to the pipelines of Prime Medicine or Beam Therapeutics or any other editing biotech has nothing to do with how robust and versatile the underlying technologies are. All are clinic-grade and can support huge pipelines. @drrichjlaw @ADeAngelis_bio And that matters societally but also for the scale and timeline of a company that came out with some pretty sweeping ambitions @drrichjlaw @ADeAngelis_bio And that matters societally but also for the scale and timeline of a company that came out with some pretty sweeping ambitions"
X Link 2024-10-01T20:13Z 15.7K followers, 12.7K engagements

"Epistasis - a lovely Greek-origin word that frightens undergraduates in Genetics. No longer. The first gene editing medicine Casgevy works by targeting an epistatic suppressor of the disease-causing gene. Here in HD a small molecule does same. https://endpts.com/loqus23-bags-43m-in-series-a-to-move-huntingtons-drug-into-first-human-study/ https://endpts.com/loqus23-bags-43m-in-series-a-to-move-huntingtons-drug-into-first-human-study/"
X Link 2024-10-02T15:51Z 15.6K followers, [----] engagements

"If everyone who thinks David Baker is amazing having collaborated with him and enjoyed it tremendously because he's just epic - were to post something about that on this site . it would crash the server. So I won't. . wait a minute. :-) https://newsroom.uw.edu/news-releases/biochemist-david-baker-receives-nobel-prizeutm_source=uwhp&utm_medium=tiles&utm_campaign=david-baker-nobel-prize-announcement https://newsroom.uw.edu/news-releases/biochemist-david-baker-receives-nobel-prizeutm_source=uwhp&utm_medium=tiles&utm_campaign=david-baker-nobel-prize-announcement"
X Link 2024-10-09T12:32Z 15.7K followers, [----] engagements

""Investor impatience" I can't even More gene editing layoffs Investors showing little patience for the field particularly new companies trying to find ways of inserting whole genes into patients https://t.co/1loXSWfD3D More gene editing layoffs Investors showing little patience for the field particularly new companies trying to find ways of inserting whole genes into patients https://t.co/1loXSWfD3D"
X Link 2024-10-14T10:54Z 15.7K followers, [----] engagements

"This is why I read @statnews every morning. Where else can you find a quote from a biotech investor that is so magnificently self-incriminating wrt the pathological - and poisonous - short-termism in that community of people πŸ™@ADeAngelis_bio"
X Link 2024-10-15T11:49Z 15.6K followers, [----] engagements

"@aedwards02 @statnews @ADeAngelis_bio Aaron and I in turn can't tell you how sorry I am you - along with our entire sector - have to deal with this"
X Link 2024-10-15T12:40Z 15.7K followers, [---] engagements

"I met Prime Minister Cameron at a visit to the UK recently. His family's story of living with genetic disease is deeply affecting - and his vision and drive towards enabling disruptive change in developing genetic medicines for N=rare is timely and compelling. As a father I know all too well the impact of rare diseases. The steps were taking now means that soon families like mine will have hope. The mission of the @OHRareDisease Centre to develop new treatments for rare diseases is hugely ambitious but this is the right time the https://t.co/74KbF8gxvI As a father I know all too well the"
X Link 2024-10-16T11:23Z 15.6K followers, [----] engagements

""Chuffed" is what contestants on the Great British Baking Show say when Paul Hollywood gives them the famous Handshake. I think it means - "thrilled beyond words." β™₯ Jennifer Doudna offers The @NewYorker her top [--] #CRISPR books to understand the gene-editing revolution: CRISPR People by @HankGreelyLSJU; The Codebreaker by @WalterIsaacson; and my own Editing Humanity Im so chuffed https://t.co/SeBGHbvpZg Jennifer Doudna offers The @NewYorker her top [--] #CRISPR books to understand the gene-editing revolution: CRISPR People by @HankGreelyLSJU; The Codebreaker by @WalterIsaacson; and my own"
X Link 2024-10-17T14:42Z 15.7K followers, [----] engagements

"The chief vendor and proponent of this snake oil - Jonathan Anomaly - has zero education in Genetics. I checked. This is like someone with zero experience in structural engineering - selling earthquake-resistant houses. https://www.theguardian.com/science/2024/oct/18/us-startup-charging-couples-to-screen-embryos-for-iq https://www.theguardian.com/science/2024/oct/18/us-startup-charging-couples-to-screen-embryos-for-iq"
X Link 2024-10-19T21:45Z 16.1K followers, [----] engagements

"The off-target analysis Vertex did for Casgevy the first approved CRISPR medicine is public information - and is exemplary. Gr9 (98) choice @statnews @MeganMolteni https://www.statnews.com/meet-the-2024-stat-wunderkinds/zach-zappala/ https://www.statnews.com/meet-the-2024-stat-wunderkinds/zach-zappala/"
X Link 2024-10-25T14:10Z 16.1K followers, [----] engagements

"Recent public statements claimed immigrants with "bad genes" are "poisoning the blood of our country." As an immigrant and a human being I take this personally. As a professor of Genetics I teach that this is nonscientific dung - see my lecture (2004): https://www.dropbox.com/scl/fi/x2vbfltevjs6nn1j7sknc/Genetics-of-IQ-Fyodor-Urnov-lecture-Dec-2004-MCB140-UC-Berkeley.pdfrlkey=ikn3gowtfxxelzsy4ks09mctz&dl=0 https://www.dropbox.com/scl/fi/x2vbfltevjs6nn1j7sknc/Genetics-of-IQ-Fyodor-Urnov-lecture-Dec-2004-MCB140-UC-Berkeley.pdfrlkey=ikn3gowtfxxelzsy4ks09mctz&dl=0"
X Link 2024-10-29T17:48Z 16.1K followers, [----] engagements

"This is tragic and the only words are - other than mourn - to learn as much as we can about what happened to honor the memory of this brave person who volunteered to be on the trial - and make the therapy safer moving forward. Patient dies in Beam Therapeutics trial of CRISPR sickle cell treatment https://t.co/i3Mqj4hRtC via @statnews Patient dies in Beam Therapeutics trial of CRISPR sickle cell treatment https://t.co/i3Mqj4hRtC via @statnews"
X Link 2024-11-05T13:58Z 15.7K followers, [----] engagements

"#CRISPR cures on-demand can and will be scaled nationwide. In this talk at the Oxford-Harrington symposium I argue - with data - that the first nation to do so will be the United Kingdom and describe an actionable path to that goal. https://youtu.be/qlzhcYh7cLMsi=1mM52JOBsMeHPCZg https://youtu.be/qlzhcYh7cLMsi=1mM52JOBsMeHPCZg"
X Link 2024-11-11T13:52Z 15.6K followers, [----] engagements

"Interested in #CRISPR-based gene editing therapies This symposium is for you It'll cover the full "target discovery to clinic" journey in talks by SMEs from academia+ industry. Room left for late abstract-based presentations (submit by Dec 5) Pls RT πŸ™ https://www.keystonesymposia.org/conferences/conference-listing/meeting/C12025 https://www.keystonesymposia.org/conferences/conference-listing/meeting/C12025"
X Link 2024-11-30T18:54Z 15.6K followers, [----] engagements

"Dr Peter Marks (head of FDA CBER) makes an apt analogy between #CRISPR and razors in this @NPR @robsteinnews piece about work we are doing at the @igisci @UCBerkeley to expand the clinical footprint of gene editing to children with "N=1" gene mutations. https://www.npr.org/2024/12/03/nx-s1-5090880/customized-crispr-treatments-could-help-people-with-rare-genetic-disorders https://www.npr.org/2024/12/03/nx-s1-5090880/customized-crispr-treatments-could-help-people-with-rare-genetic-disorders"
X Link 2024-12-04T12:20Z 15.6K followers, [----] engagements

"Painful and sobering news. My heart breaks for my fellow editors. Also a loss for patients. Our sector needs a new model - it will come out of innovative partnerships between academia nonprofit and industry. Editas Medicine lays off 65% of staff and shelves lead gene-editing program https://t.co/tNWrOXdhUW via @statnews Editas Medicine lays off 65% of staff and shelves lead gene-editing program https://t.co/tNWrOXdhUW via @statnews"
X Link 2024-12-12T23:02Z 15.7K followers, 13.6K engagements

""At the end of every hard-earned day People find a reason to believe" (Springsteen) Watch this video. It's data-based reason to believe. Don't forget Kleenex. I watched this video [--] times and cried every single time. 10-month-old KJ Muldoon who landed in international headlines after receiving a first-of-its-kind gene-editing treatment was released from the hospital last week. The bespoke therapy was developed by @kiranmusunuru & Dr. Rebecca Ahrens-Nicklas. https://t.co/m5PCsMtFtd 10-month-old KJ Muldoon who landed in international headlines after receiving a first-of-its-kind gene-editing"
X Link 2025-06-09T21:27Z 15.7K followers, [----] engagements

Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing

@UrnovFyodor
/creator/twitter::UrnovFyodor