#  @PearlF Pearl Freier
Pearl Freier posts on X about insurance, rfk, $abbv, ceo the most. They currently have [-------] followers and [----] posts still getting attention that total [-----] engagements in the last [--] hours.
### Engagements: [-----] [#](/creator/twitter::26368450/interactions)
- [--] Week [------] +188%
- [--] Month [-------] +58%
- [--] Months [-------] +86%
- [--] Year [---------] -28%
### Mentions: [--] [#](/creator/twitter::26368450/posts_active)
- [--] Week [--] +27%
- [--] Month [---] +50%
- [--] Months [---] +64%
- [--] Year [---] -15%
### Followers: [-------] [#](/creator/twitter::26368450/followers)
- [--] Week [-----] +0.42%
- [--] Month [-----] +1.40%
- [--] Months [-----] +4.90%
- [--] Year [-----] +13%
### CreatorRank: [-------] [#](/creator/twitter::26368450/influencer_rank)
### Social Influence
**Social category influence**
[stocks](/list/stocks) [finance](/list/finance) [countries](/list/countries) [technology brands](/list/technology-brands) [vc firms](/list/vc-firms) [cryptocurrencies](/list/cryptocurrencies) [us election](/list/us-election) [travel destinations](/list/travel-destinations) [social networks](/list/social-networks) [celebrities](/list/celebrities)
**Social topic influence**
[insurance](/topic/insurance), [rfk](/topic/rfk) #515, [$abbv](/topic/$abbv), [ceo](/topic/ceo), [$pfe](/topic/$pfe), [acquisition](/topic/acquisition), [in the](/topic/in-the), [investment](/topic/investment), [novartis](/topic/novartis), [link](/topic/link) #2613
**Top accounts mentioned or mentioned by**
[@statnews](/creator/undefined) [@endpts](/creator/undefined) [@fiercebiotech](/creator/undefined) [@ldtimmerman](/creator/undefined) [@matthewherper](/creator/undefined) [@devahaz](/creator/undefined) [@thebiotechclub](/creator/undefined) [@bijans](/creator/undefined) [@mikeisaac](/creator/undefined) [@mcuban](/creator/undefined) [@mroliverbarnes](/creator/undefined) [@daphnezohar](/creator/undefined) [@openai](/creator/undefined) [@andrewedunn](/creator/undefined) [@chrissyfarr](/creator/undefined) [@ddiamond](/creator/undefined) [@bradloncar](/creator/undefined) [@maxonwifi](/creator/undefined) [@samdavisesq](/creator/undefined) [@grok](/creator/undefined)
**Top assets mentioned**
[AbbVie Inc (ABBV)](/topic/$abbv) [Pfizer, Inc. (PFE)](/topic/$pfe) [Novartis AG (NVS)](/topic/novartis) [Novo-Nordisk (NVO)](/topic/$nvo) [Eli Lilly and Company (LLY)](/topic/$lly) [Johnson & Johnson (JNJ)](/topic/$jnj) [Biogen Inc (BIIB)](/topic/$biib) [Bristol-Myers Squibb Co (BMY)](/topic/$bmy) [CVS Health Corp (CVS)](/topic/cvs) [Regeneron Pharmaceuticals Inc (REGN)](/topic/$regn) [GSK plc (GSK)](/topic/$gsk) [Sanofi (SNY)](/topic/sanofi) [AstraZeneca PLC (AZN)](/topic/$azn) [Moderna Inc (MRNA)](/topic/$mrna) [Basilisk (BSX)](/topic/$bsx) [Vertex Protocol (VRTX)](/topic/$vrtx) [Merck & Co., Inc. (MRK)](/topic/$mrk) [Microsoft Corp. (MSFT)](/topic/microsoft) [Intellia Therapeutics, Inc (NTLA)](/topic/$ntla) [Boston Scientific Corporation (BSX)](/topic/boston-scientific)
### Top Social Posts
Top posts by engagements in the last [--] hours
"@tarahaelle @zeynep @apoorva_nyc It would have been [--] thing to tell the public not 2use n95 & medical grade masks because those are critical supplies [--] healthcare workers but anyone telling the public that masks in general (incl cloth masks) weren't needed or helpful was misleading people even if unintentional"
[X Link](https://x.com/PearlF/status/1294663728072458243) 2020-08-15T15:54Z [----] followers, [--] engagements
"@tarahaelle @zeynep @apoorva_nyc Can you send the link please"
[X Link](https://x.com/PearlF/status/1294741667480731652) 2020-08-15T21:04Z [----] followers, [--] engagements
"Merck/MSD's Otto Ritter announced the release of DyVE (Dynamics of Value Evolution) an open source Julia framework for computational value dynamics supporting complex decision makingparticularly in R&D and business he said. https://www.linkedin.com/feed/update/urn:li:activity:6995778196172337153/ http://GitHub.com/Merck https://www.linkedin.com/feed/update/urn:li:activity:6995778196172337153/ http://GitHub.com/Merck"
[X Link](https://x.com/PearlF/status/1590062874088853504) 2022-11-08T19:25Z [----] followers, [--] engagements
"Cambridge MA-based biotech Codiak BioSciences filed for Chapter [--] & is up for sale. Founded in [----]. Story by @ky_lahucik https://endpts.com/codiak-files-for-chapter-11-bankruptcy-as-most-executives-head-for-the-exit/ https://endpts.com/codiak-files-for-chapter-11-bankruptcy-as-most-executives-head-for-the-exit/"
[X Link](https://x.com/PearlF/status/1640377856738951169) 2023-03-27T15:38Z [----] followers, [----] engagements
"Investment firm General Atlantic filed for IPO. Some of the life sciences companies they've invested in incl CinCor PathAI Immunocore Karuna Royalty Pharma Ginkgo WuXi Biologics Akero Centessa Acelyrin Hutchmed Ultima Genomics Third Harmonic https://www.reuters.com/markets/deals/general-atlantic-confidentially-files-us-ipo-bloomberg-news-2023-12-11/ https://www.reuters.com/markets/deals/general-atlantic-confidentially-files-us-ipo-bloomberg-news-2023-12-11/"
[X Link](https://x.com/PearlF/status/1734299454830682427) 2023-12-11T19:49Z [----] followers, [---] engagements
"@bcmerchant I don't know if it's a new era when I think most of the people you listed above were on his business advisory council in [----] which seemed to fall apart less than a year later. It's also unfair to compare Cook & Pichai with Musk's relationship with Trump"
[X Link](https://x.com/PearlF/status/1854285004177813867) 2024-11-06T22:09Z [----] followers, [--] engagements
"Gilead is also one of Xilio Therapeutics collaborators & paid $43.5M upfront as part of deal announced in March [----] "for the rights to develop and commercialize the biotech's tumor-activated IL-12 candidate. $GILD $XLO"
[X Link](https://x.com/PearlF/status/1889808913295650928) 2025-02-12T22:48Z [----] followers, [----] engagements
"Here's the Boston Business Journal story about Foghorn Therapeutics moving to Watertown $FHTX https://www.bizjournals.com/boston/news/2025/07/02/foghorn-cambridge-watertown-lease.htmlutm_source=st&utm_medium=en&utm_campaign=ae&utm_content=BO&j=40531126&senddate=2025-07-02&utm_term=ep1&empos=p1 https://www.bizjournals.com/boston/news/2025/07/02/foghorn-cambridge-watertown-lease.htmlutm_source=st&utm_medium=en&utm_campaign=ae&utm_content=BO&j=40531126&senddate=2025-07-02&utm_term=ep1&empos=p1"
[X Link](https://x.com/PearlF/status/1940499275064266919) 2025-07-02T19:54Z [----] followers, [---] engagements
"Pfizer's EVP/CDO also described some of AI's impact on drug discovery incl identification of drug targets for cancer 50% faster than other methods she said $PFE: "our proprietary OncoScout cancer target identification engine helped us identify two actionable targets in breast & prostate cancer that are in experimental validation achieving this at least 50% faster than traditional methods." https://twitter.com/i/web/status/2011893730597359726 https://twitter.com/i/web/status/2011893730597359726"
[X Link](https://x.com/PearlF/status/2011893730597359726) 2026-01-15T20:10Z [----] followers, [----] engagements
"Pfizer & N*vavax enter into a licensing agreement & pays $30M upfront w/milestones up to $500M. Pfizer will be able to use the Matrix-M adjuvant technology for up to [--] disease areas with its products. Link to the press release is in the reply"
[X Link](https://x.com/PearlF/status/2013641238059037057) 2026-01-20T15:54Z [----] followers, [---] engagements
"Here's a link to the ARPA-H story in @FierceBiotech https://www.fiercebiotech.com/research/arpa-h-director-eyes-future-beyond-vaccines-and-winning-biotech-race-against-china https://www.fiercebiotech.com/research/arpa-h-director-eyes-future-beyond-vaccines-and-winning-biotech-race-against-china"
[X Link](https://x.com/PearlF/status/2013652337361850620) 2026-01-20T16:38Z [----] followers, [----] engagements
""When do we get the 1st AI-developed drug" CNBC's @SaraEisen asked Pfizer CEO Albert Bourla. Bourla responded: "I think you will not see an AI-solely developed drug. But you will see a drug that is better & comes to the market faster because of the AI." $PFE A link to the CNBC video/interview is in the reply https://twitter.com/i/web/status/2013690916666519553 https://twitter.com/i/web/status/2013690916666519553"
[X Link](https://x.com/PearlF/status/2013690916666519553) 2026-01-20T19:11Z [----] followers, [----] engagements
"Pfizer CEO on AI in his post below: "There were many conversations about AI's impact but I think we are often asking the wrong question. The question is not how we do the same with less. It is how we do much much more with more.""
[X Link](https://x.com/PearlF/status/2014727337443524859) 2026-01-23T15:50Z [----] followers, [----] engagements
"Discussions are underway to boycott the World Cup when its in the US this year. This would be similar to when countries boycotted the Olympics when it was in Moscow in 1980: German soccer federation official wants World Cup boycott considered because of Trump https://t.co/GWisxWJSry German soccer federation official wants World Cup boycott considered because of Trump https://t.co/GWisxWJSry"
[X Link](https://x.com/PearlF/status/2014902738870550567) 2026-01-24T03:27Z [----] followers, [----] engagements
"Siqi Chen's 6-year old daughter Mira was diagnosed w/ a rare brain tumor adamatinomatous craniopharyngioma in '24. Last night @blader shared an app/MRI viewer he built to track tumor progression & shared how others could use it too. Mira's been responding well to an experimental treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibits VEGF proteins). See Siqi's post: over the weekend i built an app that i sincerely hope you will never have a need for but if you do happen to need a friendly free private mri viewer"
[X Link](https://x.com/PearlF/status/2015814128439275770) 2026-01-26T15:48Z [----] followers, [---] engagements
"Some advice for US from Novartis/Gal on being more competitive w/China on clinical trials: "Form a recognition system for hospitals which excel in trial leadership using objective measures (e.g. number of trials patients recruited etc) $NVS"
[X Link](https://x.com/PearlF/status/2015848796782039248) 2026-01-26T18:06Z [----] followers, [----] engagements
"@lulumeservey @MikeIsaac Is it considered a slur to refer to someone like Margaret Hoover as a conservative-leaning author/commentator/podcaster"
[X Link](https://x.com/PearlF/status/2016327737145798859) 2026-01-28T01:49Z [----] followers, [---] engagements
"And FP had a small/niche audience anyway it's not as if they were getting Alex Cooper or Joe Rogan numbers. It looks like Ellison hired BW hoping to pick up more of Fox News' audience Her 1st big interview was someone that mostly appeals to the Fox audience & the ratings were low. And the whole Twitter Files thing was it mostly a niche group that was interested in that https://twitter.com/i/web/status/2016937935132598524 https://twitter.com/i/web/status/2016937935132598524"
[X Link](https://x.com/PearlF/status/2016937935132598524) 2026-01-29T18:14Z [----] followers, [--] engagements
"Aetna Wun Trombley left NGM Biopharmaceuticals in March to become CEO of targeted protein degradation company co-founded by @CarolynBertozzi & Versant Ventures' Clare Ozawa Lycia Therapeutics. $50M round. @BiotechFischer is Board director. LYTACS platform https://bit.ly/2BUTJT0 https://bit.ly/2BUTJT0"
[X Link](https://x.com/PearlF/status/1270848615217541120) 2020-06-10T22:41Z [----] followers, [--] engagements
"GE Ventures alum @OliverKeownMD is Director & co-founder of Sunnyvale CA-based @IntuitiveSurg corporate venture capital arm Intuitive Ventures & announced $100M fund. Digital health precision diagnostics platform technologies & medtech. Congrats https://bit.ly/35CuU9v https://bit.ly/35CuU9v"
[X Link](https://x.com/PearlF/status/1321099421472444416) 2020-10-27T14:40Z [----] followers, [--] engagements
"Risa Stack joined RA Capital as Venture Partner [--] expand West Coast presence & supporting newco formation/incubation. She was a partner at KPCB & co-founded Veracyte. Then GE Ventures' General Mgr of New Business Creation & involved w/ Evidation Health Vineti & more. Congrats"
[X Link](https://x.com/PearlF/status/1333517630393765890) 2020-11-30T21:05Z [----] followers, [--] engagements
"NY-based Stablix Therapeutics launched last wk w/ $63M led by founding investor Versant Ventures w/participation from NEA Cormorant Euclidean &Alexandria. Research inspired by work in Henry Colecraft's lab/Columbia. Versant's @carlo_rizzuto is acting CEO https://bit.ly/3iBmjMA https://bit.ly/3iBmjMA"
[X Link](https://x.com/PearlF/status/1403503891476516867) 2021-06-12T00:06Z [----] followers, [--] engagements
"Digital health/health analytics company Apervita has ceased operations as of 10/1 after having raised a total of $59.5M in VC financing from investors over the years including Optum Ventures GE Ventures Baird Capital & Pritzker.(Crunchase data) https://www.healthcareitnews.com/news/apervita-ceases-operations https://www.healthcareitnews.com/news/apervita-ceases-operations"
[X Link](https://x.com/PearlF/status/1446192223763185668) 2021-10-07T19:14Z [----] followers, [--] engagements
"Pfizer was [--] of [--] bidders in bankruptcy court for Covid-flu at-home test developer Lucira Health with $21.2M & runner up Pearsanta filed an objection on Tuesday to the planned sale of the Emeryville CA company to Pfizer: Story by @rleuty_biotech https://www.bizjournals.com/sanfrancisco/news/2023/04/11/flu-covid-pfizer-lucira-pfe-pearsanta-aditxt-adtx.html https://www.bizjournals.com/sanfrancisco/news/2023/04/11/flu-covid-pfizer-lucira-pfe-pearsanta-aditxt-adtx.html"
[X Link](https://x.com/PearlF/status/1645882378601082882) 2023-04-11T20:11Z [----] followers, [---] engagements
"Boulder CO-based clinical stage oncology company @OnKureTx announced $54M Series C round. Their pipeline includes a collaboration with Pfizer on Phase [--] trial with their oral Class [--] HDAC inhibitor for the treatment of NRAS melanoma & their lead discovery program is OKI-219 a selective PI3K alpha H1047R inhibitor. https://www.globenewswire.com/news-release/2023/05/23/2674144/0/en/OnKure-Therapeutics-Announces-54-Million-Series-C-Financing.html https://twitter.com/i/web/status/1661395834716540930"
[X Link](https://x.com/PearlF/status/1661395834716540930) 2023-05-24T15:36Z [----] followers, [---] engagements
"Japanese pharma Astellas will license & develop new gene therapy from San Diego-based biotech startup co-founded by Boston Children's Hospital researcher Alan Beggs for a devastating rare muscle disorder (X-linked myotubular myopathy). Comments from @MCRPM https://www.statnews.com/2023/06/08/xlmtm-gene-therapy-astellas-pharma/ https://www.statnews.com/2023/06/08/xlmtm-gene-therapy-astellas-pharma/"
[X Link](https://x.com/PearlF/status/1666774705188089859) 2023-06-08T11:50Z [----] followers, [----] engagements
"San Diego-based gene therapy Kate Therapeutics also announced $51M Series A co-led by Versant Ventures & Los Angeles-based VC Westlake Village BioPartners with participation from Osage University Partners & UF Innovate. CEO is @kforrestdna Congrats to all involved https://www.prnewswire.com/news-releases/kate-therapeutics-debuts-with-51-million-series-a-to-develop-next-generation-genetic-medicines-to-treat-muscle-and-heart-diseases-301844583.html"
[X Link](https://x.com/PearlF/status/1666777260559400961) 2023-06-08T12:00Z [----] followers, [---] engagements
"Sharon Kedar co-founder & partner at Northpond Ventures @npv_vc posted on Linked In after the acquisition of one of their portfolio companies by Lilly for $2.4B was announced. On $DICE Therapeutics she said [--] yrs ago when they invested in the B round it https://www.linkedin.com/feed/update/urn:li:activity:7076964678630789121/updateEntityUrn=urn%3Ali%3Afs_feedUpdate%3A%28V2%2Curn%3Ali%3Aactivity%3A7076964678630789121%29 https://www.linkedin.com/feed/update/urn:li:activity:7076964678630789121/updateEntityUrn=urn%3Ali%3Afs_feedUpdate%3A%28V2%2Curn%3Ali%3Aactivity%3A7076964678630789121%29"
[X Link](https://x.com/PearlF/status/1671590490834182148) 2023-06-21T18:46Z [----] followers, [----] engagements
"Biogen to acquire Plano Texas-based Reata Pharmaceuticals in cash deal w/enterprise value of $7.3B. Largest M&A transaction in BIIB's history eclipsing '03 merger with Idec ($6.8B) https://investors.biogen.com/news-releases/news-release-details/biogen-acquire-reata-pharmaceuticals https://investors.biogen.com/news-releases/news-release-details/biogen-acquire-reata-pharmaceuticals"
[X Link](https://x.com/PearlF/status/1684891525770031104) 2023-07-28T11:40Z [----] followers, 12.1K engagements
"Ex Kleiner Perkins & ex GE Ventures partner Risa Stack ex Mohr Davidow & GE Ventures partner Rowan Chapman & ex B Capital's @Widya__Mulya started a new life sciences/tech VC firm story by @rleuty_biotech Congrats https://www.bizjournals.com/sanfrancisco/news/2023/12/21/bevc-uc-berkeley-biotech-startups.html https://www.bizjournals.com/sanfrancisco/news/2023/12/21/bevc-uc-berkeley-biotech-startups.html"
[X Link](https://x.com/PearlF/status/1737997883482268110) 2023-12-22T00:46Z [----] followers, [----] engagements
""Platform companies may therefore have to be constructed differently with more tightly controlled spending. Leaner Rizzuto said with smaller staffs more outsourced functions and smaller physical footprints." Versant Ventures Managing Director @carlo_rizzuto #JPM24 New from #JPM24: A look at how #biotech #startups may be built in the aftermath of the sector's pullback. Newly optimistic biotech investors weigh lessons of sectors downturn https://t.co/wRcOJUwBwx New from #JPM24: A look at how #biotech #startups may be built in the aftermath of the sector's pullback. Newly optimistic biotech"
[X Link](https://x.com/PearlF/status/1745546140769022447) 2024-01-11T20:40Z [----] followers, [---] engagements
""Christos Kyratsous Ph.D. co-head of Regeneron Genetic Medicines says the DB-OTO program was conceived in a brainstorming session between Regeneron & Decibel Therapeutics about six years ago where they considered what diseases they could make an impact in." #ASGCT2024 $REGN Two congenitally deaf children due to mutations of the otoferlin gene can now hear for the first time after being treated with Regeneron's investigational AAV gene therapy DB-OTO in CHORD clinical trial according to data presented at #ASGCT2024. https://t.co/s61j7aZnDJ $REGN https://t.co/NEFCipEzuU Two congenitally deaf"
[X Link](https://x.com/PearlF/status/1788255727112348090) 2024-05-08T17:12Z [----] followers, [----] engagements
"Novartis's Chief Strategy & Growth Officer Ronny Gal wrote a post re: their collab w/ Versant Ventures to form a new Vancouver Canada-based biotech Biorealis Biosciences. Focused on developing next-generation xRNA-based medicines for kidney disease https://www.linkedin.com/posts/ronny-gal-a5b769_novartis-employs-creative-deal-structure-activity-7232360966888263681-AYCsutm_source=share&utm_medium=member_desktop https://www.linkedin.com/posts/ronny-gal-a5b769_novartis-employs-creative-deal-structure-activity-7232360966888263681-AYCsutm_source=share&utm_medium=member_desktop"
[X Link](https://x.com/PearlF/status/1826623190199927209) 2024-08-22T14:11Z [----] followers, [----] engagements
"NYC-based @formationbio recruited @DavidASteinberg to be their CBO. Prior to Formation DS was a GP at Longwood Fund for [--] yrs (after [--] yrs at PureTech) & was founding CEO of Pyxis Oncology Rectify Be Biopharma & more. Formation Bio is seeking to in-license non-oncology Phase II & III assets focusing on small molecules & biologic molecules (Abs peptides bispecifics oligos etc.). Formation's collaborators incl Sanofi & Open AI & they recently raised $372M Series D. Their investors incl Sanofi A16Z Thrive Capital Sequoia Emerson Collective & more. Congrats"
[X Link](https://x.com/PearlF/status/1851390406346621085) 2024-10-29T22:27Z [----] followers, [---] engagements
"WuXi AppTec plans to sell the US & UK-based operations of their cell & gene therapy business to NY-based PE firm Altaris. Altaris acquired digital health company Sharecare in $518M deal in Oct. Story below: #WuXiAppTec which is among five Chinese #CDMOs targeted by the #BIOSECUREact is selling the U.S. and U.K.-based operations of #WuXiAdvancedTherapies its #cellandgenetherapy unit to New York-headquartered investment firm Altaris. https://t.co/TW7Ib13Eb6 #pharmamanufacturing #WuXiAppTec which is among five Chinese #CDMOs targeted by the #BIOSECUREact is selling the U.S. and U.K.-based"
[X Link](https://x.com/PearlF/status/1872262856324046895) 2024-12-26T12:47Z [----] followers, [----] engagements
"AbbVie announced a new oncology R&D collab w/ Waltham MA-based clinical stage immunooncology Xilio Therapeutics. T-cell engagers. $52M upfront (incl $10M equity) & potential up to $2.1B. CEO is @OtherReneRusso $ABBV $XLO https://www.fiercebiotech.com/biotech/abbvie-pays-xilio-52m-upfront-latest-t-cell-engager-deal https://www.fiercebiotech.com/biotech/abbvie-pays-xilio-52m-upfront-latest-t-cell-engager-deal"
[X Link](https://x.com/PearlF/status/1889808559158051257) 2025-02-12T22:47Z [----] followers, [----] engagements
"Piece by @JacobPlieth said that Xilio Therapeutics only had "just a few months' cash in the bank" until the AbbVie deal w/$52M upfront was announced today. "Importantly it buys the biotech some more time during which it might be able to generate more data and perhaps seek fresh cash from investors." 1/n https://twitter.com/i/web/status/1889810952381415533 https://twitter.com/i/web/status/1889810952381415533"
[X Link](https://x.com/PearlF/status/1889810952381415533) 2025-02-12T22:56Z [----] followers, [----] engagements
"More about Xilio Therapeutics' deals and pipeline in @JacobPlieth piece below: $XLO #immunoonc https://www.oncologypipeline.com/apexonco/xilios-second-bailout https://www.oncologypipeline.com/apexonco/xilios-second-bailout"
[X Link](https://x.com/PearlF/status/1889812407658356885) 2025-02-12T23:02Z [----] followers, [---] engagements
"Moderna's former longtime Chief Digital & Operational Officer Marcello Damiani ('15-'23) is joining John Oyler's senior leadership team as BeiGene's/BeOne Medicines Chief Technology Officer. Congrats $ONC & Marcello Welcome Marcello Damiani Marcello's expertise and vision will be a key part of our journey as we drive digital innovation to new heights. We look forward to the impact he will make as part of our growing team. Welcome Marcello Damiani Marcello's expertise and vision will be a key part of our journey as we drive digital innovation to new heights. We look forward to the impact he"
[X Link](https://x.com/PearlF/status/1919430723653562544) 2025-05-05T16:35Z [----] followers, [----] engagements
"Another biotech leaving Cambridge for Watertown MA: [--] of Eli Lilly's collaborators Foghorn Therapeutics terminated its Cambridge/Tech Square lease [--] yrs early to lease [-----] sq ft at [--] Coolidge Ave in Watertown (another Alexandria building). Story by @hannah_reports $FHTX"
[X Link](https://x.com/PearlF/status/1940497863924170938) 2025-07-02T19:48Z [----] followers, [----] engagements
"Japanese medical device company Terumo plans to acquire University of Oxford spinout OrganOx for 1.5B. OrganOx specializes in advanced organ preservation devices for Normothermic Machine Perfusion (NMP) & can preserve organs longer by "circulating oxygen and nutrient rich perfusate through the organ at near-body temperature" 1/n https://twitter.com/i/web/status/1960017551074656517 https://twitter.com/i/web/status/1960017551074656517"
[X Link](https://x.com/PearlF/status/1960017551074656517) 2025-08-25T16:32Z [----] followers, [---] engagements
"Praxis Precision Medicines will discuss the epilepsy drug clinical trial results at the American Epilepsy Society Annual Meeting on Saturday @AmEpilepsySoc #AES2025"
[X Link](https://x.com/PearlF/status/1997034909832302735) 2025-12-05T20:06Z [----] followers, [---] engagements
"Novo Nordisk has a car driving around Union Square advertising the new pill version of Wegovy according to @statnews @elaineywchen #JPM26 #JPM2026. $NVO"
[X Link](https://x.com/PearlF/status/2010845138432483460) 2026-01-12T22:43Z [----] followers, [----] engagements
"Amgen & direct-to-patient healthcare company @ro announced a research collaboration to study insurance coverage of GLP-1 drugs #JPM26 #JPM2026. Ro's CEO & co-founder is @ZReitano. Millions of patients have used Ro to check their insurance & goals from the joint collab with Amgen will incl spotlighting where gaps in coverage for patients exist & how to expand access to treatment as the next generation of GLP-1s come to market. A link to the press release is in the reply. https://twitter.com/i/web/status/2011225728428171687 https://twitter.com/i/web/status/2011225728428171687"
[X Link](https://x.com/PearlF/status/2011225728428171687) 2026-01-13T23:55Z [----] followers, [----] engagements
"Amgen's VP Center for Observational Research Brian Bradbury on the research & RWD collab w/@ro on GLP-1s #JPM26 #JPM2026 $AMGN: "Through this collaboration we aim to leverage Ros robust real-world data across the care ecosystem to better understand the patient experience & identify where limitations & unmet needs persist. Together we can translate those insights into future therapy development innovations in care delivery & greater patient outcomes." https://twitter.com/i/web/status/2011228297179299978 https://twitter.com/i/web/status/2011228297179299978"
[X Link](https://x.com/PearlF/status/2011228297179299978) 2026-01-14T00:06Z [----] followers, [----] engagements
"Regeneron's co-founder & CSO on AI: "You @matthewherper mentioned that we created REGN-Cov that saved Trumps life. That was in the clinic in [--] or [--] months from initiating the project to going into a human being; AI cant compete with that." #JPM26 #JPM2026 Regeneron's chief scientist George Yancopoulos has some thoughts about the use of AI in medicine. https://t.co/DyxwvW06hw Regeneron's chief scientist George Yancopoulos has some thoughts about the use of AI in medicine. https://t.co/DyxwvW06hw"
[X Link](https://x.com/PearlF/status/2011778391918166176) 2026-01-15T12:32Z [----] followers, [----] engagements
"Here's a link to the Boston Scientific/Penumbra story by @MedTechDive @EliseReuter $BSX #PEN #JPM26 #JPM2026 https://www.medtechdive.com/news/boston-scientific-acquire-penumbra/809734/ https://www.medtechdive.com/news/boston-scientific-acquire-penumbra/809734/"
[X Link](https://x.com/PearlF/status/2011875252842922218) 2026-01-15T18:56Z [----] followers, [---] engagements
"1 of the reasons the #JPM26 conference will probably always be in SF is because Bay Area is #1 in AI medtech & VC & is always in the Top [--] for biotech. And CA has Nvidia Google Apple Amgen Genentech/Roche Gilead Illumina & BioMarin to name a few Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis https://t.co/Rv9tIvlYyZ Boston Scientific $BSX plans to acquire Alameda CA-based"
[X Link](https://x.com/PearlF/status/2011882025918349665) 2026-01-15T19:23Z [----] followers, [----] engagements
"Misleading info by Bowden on vaccines. Many doctors' offices across the US were getting paid $40 for Covid vaccine shots in [----] for patients covered by United Health. Most people don't go to the hospital setting to get vaccinated & I don't know what Houston Methodist charges for hospitalized patients https://twitter.com/i/web/status/2012721912934248895 https://twitter.com/i/web/status/2012721912934248895"
[X Link](https://x.com/PearlF/status/2012721912934248895) 2026-01-18T03:01Z [----] followers, [---] engagements
"Reportedly the largest autonomous lab in the world is in South Boston at @ginkgo. Can also work with their internal team remotely on "autonomous labs as a service" or cloud lab & CRO. They're down the street from Vertex. See below: What lab experiments would *you* like to run remotely on our autonomous lab How will *you* unlock biology if you can focus on hypotheses & data and leave the wet work to us Reach out to me if youd like to brainstorm What lab experiments would *you* like to run remotely on our autonomous lab How will *you* unlock biology if you can focus on hypotheses & data and"
[X Link](https://x.com/PearlF/status/2014791658877890955) 2026-01-23T20:05Z [----] followers, [----] engagements
"If your startup announces a $1B + financing as its first round suggestions below are to refer to it as a coconut round or as an avocado round or something else instead of referring to it as a seed round. I can't relate personally but here's the article below: When a startup is born fully capitalized and worth billions seed no longer fits. Call it a coconut or avocado roundthe language hasnt caught up. Some data some thoughts some @beffjezos https://t.co/QQTRGIZKqU When a startup is born fully capitalized and worth billions seed no longer fits. Call it a coconut or avocado roundthe language"
[X Link](https://x.com/PearlF/status/2015775602981077322) 2026-01-26T13:15Z [----] followers, [----] engagements
"Here's a link to Novartis $NVS senior exec Ronny Gal's Linked In post today w/ his suggestions for how the US system for clinical trials could get better & be more competitive with China: https://www.linkedin.com/pulse/early-clinical-trials-go-so-goes-innovation-us-risk-ronny-gal-ivtse/trackingId=N%2BViuFvljeSW7KhXPTjSYw%3D%3D https://www.linkedin.com/pulse/early-clinical-trials-go-so-goes-innovation-us-risk-ronny-gal-ivtse/trackingId=N%2BViuFvljeSW7KhXPTjSYw%3D%3D"
[X Link](https://x.com/PearlF/status/2015846464438603821) 2026-01-26T17:57Z [----] followers, [----] engagements
"if the "zombie cell clearing cream" is a Weleda product it may be available at Erewhon or even Whole Foods :) Longevity going mainstream is mostly quite good for loyal But it is also.quite cringe at times zombie cell clearing cream https://t.co/2xXxWrer2h Longevity going mainstream is mostly quite good for loyal But it is also.quite cringe at times zombie cell clearing cream https://t.co/2xXxWrer2h"
[X Link](https://x.com/PearlF/status/2016317131692855729) 2026-01-28T01:07Z [----] followers, [----] engagements
"AstraZeneca & Pfizer alum now Biorelate CSO made some suggestions for providing frameworks for making AI in drug discovery more of a measurable asset incl the use of well established value quantification methods like PTRS but without the R. "Traditionally applied to later-stage clinical assets we can reuse the concept (as straight PTS no R) to offer a structured approach in earlier phases of drug discovery. This would provide a quantifiable framework for target evaluation and crucially enable tracking of AI contributions. Expressed as a percentage (0100%) PTS as envisioned here would"
[X Link](https://x.com/PearlF/status/2017401161410621712) 2026-01-31T00:54Z [----] followers, [---] engagements
"Here's a link to the op-ed in Biopharma Boardroom: https://www.biopharmaboardroom.com/opinion/1/4280/is-ai-pharmas-fools-gold-why-evidence-driven-metrics-will-define-real-roi.html https://www.biopharmaboardroom.com/opinion/1/4280/is-ai-pharmas-fools-gold-why-evidence-driven-metrics-will-define-real-roi.html"
[X Link](https://x.com/PearlF/status/2017401469775839666) 2026-01-31T00:56Z [----] followers, [---] engagements
"@dbinthed @ramez The poll below suggests to me there is a messaging problem of some kind. I was speculating on what it might be even though it's surprising to me that the approval rating isn't much lower for thuggish tactics law-breaking & murder https://x.com/Noahpinion/status/2018730290991304994s=20 Yet another poll in which Americans trust REPUBLICANS more on immigration than Democrats. Even after the ICE murders. https://t.co/LW1wKBZdeJ https://x.com/Noahpinion/status/2018730290991304994s=20 Yet another poll in which Americans trust REPUBLICANS more on immigration than Democrats. Even"
[X Link](https://x.com/PearlF/status/2018872209868280119) 2026-02-04T02:20Z [----] followers, [--] engagements
"@cremieuxrecueil How come it doesn't have to go through clinical trials & is there evidence that the pill is safe & that it works for weight loss Does the pill have side effects Why does Novo have to get FDA approval but Hims doesn't"
[X Link](https://x.com/PearlF/status/2019448488807833680) 2026-02-05T16:30Z [----] followers, [----] engagements
"One more thing on Hims' new GLP-1 pill story below by @ZacharyBrennan confirms that the FDA holds Novo $NVO & Lilly $LLY to a higher standard than $HIMS. "Hims & Hers said all of its compounded active pharmaceutical ingredients 'are sourced exclusively from FDA-registered facilities' but pharmaceutical-grade pills are required to adhere to a higher level of safety assurances than compounded drugs." Our stull story: https://t.co/uTuduVRqKi Our stull story: https://t.co/uTuduVRqKi"
[X Link](https://x.com/PearlF/status/2019458943525744993) 2026-02-05T17:11Z [----] followers, [----] engagements
"@NY_LBSS @cremieuxrecueil No Ro isn't selling the same pill that Hims announced today. Here's a link to Ro's announcement last month. They're selling Novo Nordisk's Wegovy pill in partnership with the drug's manufacturer & creatorNovo. https://ro.co/weight-loss/oral-wegovy/ https://ro.co/weight-loss/oral-wegovy/"
[X Link](https://x.com/PearlF/status/2019466457017417977) 2026-02-05T17:41Z [----] followers, [--] engagements
"Novartis has a provocative [--] second ad airing during Super Bowl this weekend. It's an awareness ad for prostate cancer screening/blood testing. Gronk is in it & prostate cancer survivor Coach Arians. h/t @damiangarde @statnews. Link to story & video is in the reply $NVS #pcsm"
[X Link](https://x.com/PearlF/status/2019562876881736047) 2026-02-06T00:04Z [----] followers, [--] engagements
"Here's a link to the @statnews story about commercials airing during the Super Bowl this weekend including pharmas Novartis Boehringer & Novo telehealth Ro & online pharmacy/compounder Hims https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/ https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/"
[X Link](https://x.com/PearlF/status/2019563839461945840) 2026-02-06T00:08Z [----] followers, [--] engagements
"Here's the YouTube video & Novartis' Super Bowl ad $NVS https://www.youtube.com/watchv=lMTcZb48aVU https://www.youtube.com/watchv=lMTcZb48aVU"
[X Link](https://x.com/PearlF/status/2019565771202896355) 2026-02-06T00:16Z [----] followers, [--] engagements
"Below is what Adweek said about Novartis's Super Bowl ad for '26"Novartis Gets Cheeky." $NVS It's a prostate cancer awareness ad to promote early detection & blood testing (which also supports brand awareness for the company.) Novartis is the maker of prostate cancer drug Pluvicto a targeted adioligand therapy (RLT) for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). A link to Adweek's story is in the reply: https://twitter.com/i/web/status/2019567712087797910 https://twitter.com/i/web/status/2019567712087797910"
[X Link](https://x.com/PearlF/status/2019567712087797910) 2026-02-06T00:23Z [----] followers, [---] engagements
"Here's the Adweek story about the Novartis commercial planned to air during the Super Bowl: $NVS https://www.adweek.com/convergent-tv/novartis-super-bowl-ad-tight-ends/ https://www.adweek.com/convergent-tv/novartis-super-bowl-ad-tight-ends/"
[X Link](https://x.com/PearlF/status/2019568028707352691) 2026-02-06T00:25Z [----] followers, [---] engagements
"Novartis has a provocative [--] second ad airing during Super Bowl this weekend. It's an awareness ad for prostate cancer screening/blood testing. Gronk & several football players are in it w/ prostate cancer survivor Coach Arians. h/t @damiangarde @statnews $NVS #pcsm Link to story & video is in the reply https://twitter.com/i/web/status/2019572476619964657 https://twitter.com/i/web/status/2019572476619964657"
[X Link](https://x.com/PearlF/status/2019572476619964657) 2026-02-06T00:42Z [----] followers, [---] engagements
"Here's a link to the @statnews story about commercials airing during the Super Bowl this weekend including pharmas Novartis Boehringer & Novo telehealth Ro & online pharmacy/compounder Hims https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/ https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/"
[X Link](https://x.com/PearlF/status/2019572791729967529) 2026-02-06T00:44Z [----] followers, [---] engagements
"Mark Cuban said that IVF drugs are cheaper through Tr*umpRx or that's how I interpreted his comment below. I don't know which drugs he's talking about but for some patients Tr*umpRx might be a win"
[X Link](https://x.com/PearlF/status/2019877093421547888) 2026-02-06T20:53Z [----] followers, [---] engagements
"The NIH had been moving forward w/ research for a vaccine against Epstein-Barr (EBV is linked to lymphoma MS & lupus) but federal vaccine initiatives are being stopped by HHS. A call for Congress below to intervene by directing $ to specific lines of vaccine researchw/ clear objectives enforceable milestones & mandatory reporting from HHS to ensure compliance: https://twitter.com/i/web/status/2019914604646707502 https://twitter.com/i/web/status/2019914604646707502"
[X Link](https://x.com/PearlF/status/2019914604646707502) 2026-02-06T23:22Z [----] followers, [---] engagements
""The largest study to date of leucovorins effectiveness for treating autism traits has been retracted because of data inconsistencies and statistical issues according to a notice posted last week by the European Journal of Pediatrics." Largest leucovorin-autism trial retracted https://t.co/qSa1GKgs3K Largest leucovorin-autism trial retracted https://t.co/qSa1GKgs3K"
[X Link](https://x.com/PearlF/status/2020213095323324678) 2026-02-07T19:08Z [----] followers, [---] engagements
""The retraction of this paper removes a significant portion of the already weak evidence supporting the value of folinic acid as a treatment for autism Thomas Challman a pediatrician at Geisinger College of Health Sciences who specializes in neurodevelopmental conditions wrote in an email to The Transmitter. Until we have acceptable evidence of safety and effectiveness folinic acid use as a treatment for autism is not appropriate outside of a well-designed clinical trial. https://twitter.com/i/web/status/2020213369056137273 https://twitter.com/i/web/status/2020213369056137273"
[X Link](https://x.com/PearlF/status/2020213369056137273) 2026-02-07T19:09Z [----] followers, [---] engagements
"An updated FDA org chart from @biospace: nearly 90% of senior leaders who were at the FDA a year ago are no longer there. Most FDA employees are usually "career staff" who worked for multiple FDA commissioners & years of training to be knowledgeable incl cell & gene therapies. Pazdur had worked for the Bush Obama Trump [--] & Biden administrations. He wasn't a Biden appointee"
[X Link](https://x.com/PearlF/status/1996332049364344835) 2025-12-03T21:33Z [----] followers, 111.7K engagements
"One of the world's most famous anti-vaxxers RFK Jr. is the HHS Secretary. His political appointee at the FDA unilaterally overruled FDA employees & vaccine experts & refused to review a vaccine that the EU Australia & Canada agreed to review. Here's an unlocked link to the WSJ story by @l_e_whyte https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=qiCiTx&reflink=desktopwebshare_permalink https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=qiCiTx&reflink=desktopwebshare_permalink"
[X Link](https://x.com/PearlF/status/2022164858720907754) 2026-02-13T04:24Z [----] followers, [----] engagements
"Biogen announced a new collaboration w/ Israeli biotech NeuroSense Therapeutics to assess their Phase [--] ALS candidate PrimeC's impact on neurofilaments for which elevated levels are considered an ALS biomarker. Biogen will receive blood samples from [--] trial patients which will be used for a biomarker analysis study https://www.fiercebiotech.com/biotech/lookout-next-als-biomarker-success-biogen-pens-pact-israeli-biotech https://www.fiercebiotech.com/biotech/lookout-next-als-biomarker-success-biogen-pens-pact-israeli-biotech"
[X Link](https://x.com/PearlF/status/1669018047389085697) 2023-06-14T16:24Z [----] followers, [----] engagements
"More below on Eli Lilly's acquisition of San Francisco-based biotech DICE Therapeutics for $2.4B in cash incl potential psoriasis drug & great to see win for DICE's CEO too who was prev Achaogen CEO. Story by @matthewherper $DICE $LLY https://www.statnews.com/2023/06/20/eli-lilly-to-acquire-dice-therapeutics-in-2-4-billion-deal/utm_campaign=twitter_organic&utm_source=twitter&utm_medium=social https://www.statnews.com/2023/06/20/eli-lilly-to-acquire-dice-therapeutics-in-2-4-billion-deal/utm_campaign=twitter_organic&utm_source=twitter&utm_medium=social"
[X Link](https://x.com/PearlF/status/1671128048488308737) 2023-06-20T12:09Z [----] followers, [----] engagements
"Wow FTC is intervening in a small biotech collab w/ a French pharma that could potentially help patients living w/ Pompe disease. Biotech companies need collabs w/large cos & the $ to develop new drugs: https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html"
[X Link](https://x.com/PearlF/status/1734334233923965047) 2023-12-11T22:07Z [----] followers, 88.3K engagements
"Genentech built on the experience when designing the CHIMES study for multiple sclerosis. Inozyme Pharma's COO commented: "African-American Hispanic patients with MS come to see their doctor & their doctors are actually able to show data in their population Winton said. The majority of the time thats the drug that theyre going to say I want to be on. https://twitter.com/i/web/status/1790451221590946286 https://twitter.com/i/web/status/1790451221590946286"
[X Link](https://x.com/PearlF/status/1790451221590946286) 2024-05-14T18:36Z [----] followers, [----] engagements
"@CFLabsResearch @ChrisHeery @bradloncar @BioLabsNC Norbert Bischofberger's company Kronos Bio works with Chordoms Foundation Labs in Durham"
[X Link](https://x.com/PearlF/status/1792391959484727752) 2024-05-20T03:08Z [----] followers, [--] engagements
"Mountain View CA-based biotech IGM Biosciences is the latest biotech to pivot from cancer to autoimmune disease. Their CEO CSO & Chief Medical Officer are also departing the company. Story by @JamesPharma $IGMS https://www.fiercebiotech.com/biotech/igm-completes-pivot-cancer-autoimmune-shaking-c-suite-and-hinting-layoffs https://www.fiercebiotech.com/biotech/igm-completes-pivot-cancer-autoimmune-shaking-c-suite-and-hinting-layoffs"
[X Link](https://x.com/PearlF/status/1841201876970180757) 2024-10-01T19:41Z [----] followers, [---] engagements
"Physician scientist & cancer genomics expert Howard Y. Chang discovered a new class of genes termed long noncoding RNAs can control gene activity throughout the genome. He co-founded Boundless Bio Accent Tx Orbital Tx & Cartography Bio. He starts at $AMGN on 12/16 as CSO & SVP of Research. Chang succeeds Ray Deshaies the former senior vice president of Research whose departure was announced earlier this year. Chang will report to Jay BradnerAmgen's EVP of R&D https://twitter.com/i/web/status/1859371921525428614 https://twitter.com/i/web/status/1859371921525428614"
[X Link](https://x.com/PearlF/status/1859371921525428614) 2024-11-20T23:03Z [----] followers, [----] engagements
"A Vida Ventures spokesperson told @endpts the firm is "preparing to raise a fourth fund." Fund [--] $825M was announced in mid [----] the story said. The remaining co-founder on the leadership team is Arie Belldegrun. Helen Kim & Rajul Jain are still listed as sr managing dir & managing director respectively [--] of Vida Ventures [--] co-founding managing dirs @arjun__goyal & Stefan Vitorovic left the firm h/t @ky_lahucik @maxonwifi. Biotech VC firm launched [--] yrs ago & $1.8B AUM. No word yet if theyre launching their own fund or joining another VC firm.https://t.co/Csy22cL7Df [--] of Vida Ventures 3"
[X Link](https://x.com/PearlF/status/1866616876299849772) 2024-12-10T22:51Z [----] followers, [----] engagements
"Vida Ventures' portfolio includes Allogene AskBio Capstan Therapeutics Tectonic Therapeutic Centessa Dyne Kronos Bio Kyverna Neogene Peloton Therapeutics Scorpion Therapeutics ReCode Therapeutics Volastra Vigil Neuro"
[X Link](https://x.com/PearlF/status/1866617781275463756) 2024-12-10T22:55Z [----] followers, [---] engagements
"This was the 1st sizable M&A deal of the #JPM25 news cycle2 days ago Michigan-based medtech company Stryker announced plans to buy Irvine CA-based Inari Medical in $4.9B deal. More below: #JPM2025"
[X Link](https://x.com/PearlF/status/1877146792623526121) 2025-01-09T00:14Z [----] followers, [---] engagements
"On Vera Therapeutics's fusion protein (atacicept) for IgA nephropathy Derek wrote "the Phase II for that one looked very impressive and the next readout is from a Phase 3." $VERA Derek Lowe wrote a post on @NatureMedicine 's [--] Clinical Trials That Will Shape Medicine in '25. He said he's very interested in Arvinas/ $ARVN's Phase [--] data on their estrogen receptor degrader vepdegestrant (ARV-471) "a key test for targeted protein degradation" he said Derek Lowe wrote a post on @NatureMedicine 's [--] Clinical Trials That Will Shape Medicine in '25. He said he's very interested in Arvinas/ $ARVN's"
[X Link](https://x.com/PearlF/status/1882861900062708146) 2025-01-24T18:43Z [----] followers, [----] engagements
"The US is projected to have [--] fewer new FDA-approved drugs annually & 18% fewer drugs entering clinical trials if the WH"s proposed NIH cuts are approved by Congress said Venrock VC @bobkocher & @USCSchaeffer professor @DanaPGoldman in op-ed. cc'ing @BRobertsVC"
[X Link](https://x.com/PearlF/status/1918100841497579638) 2025-05-02T00:30Z [----] followers, [----] engagements
"M&A seemed to be a rare event at Regeneron until [----] when they acquired immunooncology biotech Checkmate Pharmaceuticals. More below: 2seventy Decibel now 23andMe Regeneron loves an opportunistic M&A move for some previous high-fliers in biotech: https://t.co/418FTv6c19 2seventy Decibel now 23andMe Regeneron loves an opportunistic M&A move for some previous high-fliers in biotech: https://t.co/418FTv6c19"
[X Link](https://x.com/PearlF/status/1924436995893285124) 2025-05-19T12:08Z [----] followers, [---] engagements
"Alnylam Pharmaceuticals also raised around $26M in [----] in "Less-Than-Spectacular IPO" (from Genomeweb's headline in 6/04) I was curious how much Alnylam raised to get off the ground. It's unbelievable. $17M in combined series A and B funding back in '02. Kinda puts today's megarounds in perspective.you don't always need it if you build right. Of course costs have soared since then but still. I was curious how much Alnylam raised to get off the ground. It's unbelievable. $17M in combined series A and B funding back in '02. Kinda puts today's megarounds in perspective.you don't always need it"
[X Link](https://x.com/PearlF/status/1950948943841419502) 2025-07-31T15:57Z [----] followers, [---] engagements
"Boston-based biotech Praxis $PRAX w/good news--announced an early end to its Embold clinical trial studying their epilepsy drug relutrigine in patients w/ genetic mutations SCN2A & SCN8A developmental and epileptic encephalopathies because the trial's data monitoring committee said "it was clear relutrigines efficacy had been demonstrated." A link to the @FierceBiotech story is in the reply"
[X Link](https://x.com/PearlF/status/1997032675148955825) 2025-12-05T19:57Z [----] followers, [----] engagements
"Here's a link to the @fiercebiotech story about Praxis Precision Medicines $PRAX https://www.fiercebiotech.com/biotech/praxis-claims-efficacy-success-phase-2-seizure-trial-setting-approval-talks-fda https://www.fiercebiotech.com/biotech/praxis-claims-efficacy-success-phase-2-seizure-trial-setting-approval-talks-fda"
[X Link](https://x.com/PearlF/status/1997033151009526204) 2025-12-05T19:59Z [----] followers, [----] engagements
"Biogen's ALS gene therapy received accelerated FDA approval in '23 for rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph [--] trial published in 12/22 @JAMANeuro said that drug not only delays disease progression also helps patients regain lost function $BIIB"
[X Link](https://x.com/PearlF/status/2005689368342835685) 2025-12-29T17:16Z [----] followers, [----] engagements
""Stopping disease progression & making improvements over [--] to [--] years is unheard of in this type of ALS said 1st author Tim @MillerLabNeuro @WashUNeurology Professor & co-director of the WashU Medicine ALS Center. $BIIB Tofersen shows benefits compared with what we expect to see for these participants with about 25% of participants experiencing improvement. These results provide hope that we can change the trajectory of this devastating disease and we are optimistic we can do the same for other forms of ALS. https://twitter.com/i/web/status/2005690397633200617"
[X Link](https://x.com/PearlF/status/2005690397633200617) 2025-12-29T17:20Z [----] followers, [---] engagements
""new data on the long-term use of tofersen suggest that over about [--] years of treatment roughly 1/4 of participants in [--] study group experienced stabilization of symptoms & even functional improvement in grip strength & respiratory function." $BIIB #ALS"
[X Link](https://x.com/PearlF/status/2005691004025008404) 2025-12-29T17:22Z [----] followers, [----] engagements
"Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis"
[X Link](https://x.com/PearlF/status/2011874497683501244) 2026-01-15T18:53Z [----] followers, [----] engagements
"In case anyone was concerned about JP Morgan investment bankers this week Boston Scientific came through on the last day of the conference with $14.5B acquisition of Penumbra. #JPM26 $BSX $PEN Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis https://t.co/Rv9tIvlYyZ Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion"
[X Link](https://x.com/PearlF/status/2011876770660970505) 2026-01-15T19:02Z [----] followers, [---] engagements
"Novartis Chief Strategy Officer Ronny Gal wrote that the US is at "risk of losing its edge" in early clinical trials to China. He explains some of China's advantages incl: "Chinese hospitals have stronger incentives to participate in trials. They are ranked & evaluated on participation in trials notably early trials." A link to his Linked In post is in the reply: https://twitter.com/i/web/status/2015845639804891605 https://twitter.com/i/web/status/2015845639804891605"
[X Link](https://x.com/PearlF/status/2015845639804891605) 2026-01-26T17:53Z [----] followers, 46.3K engagements
"Novartis/Gal on advantages China has w/ their hospitals re: clinical trials: "They deliver well on commitments to patient recruiting & are motivated to be fairly compensated for their participation in trials to build their long-term reputation & scientific leadership. They also dont seek to maximize profits from trials as this is viewed as a potentially unhealthy practice." https://twitter.com/i/web/status/2015847218713133402 https://twitter.com/i/web/status/2015847218713133402"
[X Link](https://x.com/PearlF/status/2015847218713133402) 2026-01-26T18:00Z [----] followers, [----] engagements
"they said they're going to issue nearly [-----] additional H-2B guest worker visas through September but are they going to have ICE lurking in the driveways or at bus stations & parking lots to send the workers to detention centers to meet detention/deportation numbers "The Trump administration has said it will issue nearly [-----] additional H-2B guest worker visas through September effectively doubling the maximum number that can be issued in a year." https://t.co/HEOzmPWFxJ "The Trump administration has said it will issue nearly [-----] additional H-2B guest worker visas through September"
[X Link](https://x.com/PearlF/status/2017771868808196307) 2026-02-01T01:27Z [----] followers, [---] engagements
"From a few months ago after an ICE raid at a Hyundai plant in Georgia which grabbed [---] Asians who were in the US legally: "South Korean President Lee Jae Myung called for improvements in the U.S. visa system as he spoke about the Sept. [--] immigration raid that resulted in the arrest of more than [---] South Korean workers at at Hyundai's sprawling auto plant west of Savannah. https://www.pbs.org/newshour/nation/south-korean-workers-who-were-detained-in-a-hyundai-factory-raid-are-now-headed-home-heres-what-else-to-know"
[X Link](https://x.com/PearlF/status/2017773920078745944) 2026-02-01T01:36Z [----] followers, [---] engagements
"Here's the YouTube video & Novartis' [----] Super Bowl ad for prostate cancer screening/blood testing $NVS $NVS https://www.youtube.com/watchv=lMTcZb48aVU https://www.youtube.com/watchv=lMTcZb48aVU"
[X Link](https://x.com/PearlF/status/2019573249651404990) 2026-02-06T00:45Z [----] followers, [----] engagements
"@dr_coops Gronk is in it :)"
[X Link](https://x.com/PearlF/status/2020690990944879097) 2026-02-09T02:47Z [----] followers, [---] engagements
""Trial designs will prioritize early mechanistic evidence of the drugs degrading their intended protein in patients & confirm the right ligase/target pairing alongside artificial intelligence-guided degrader design and patient stratification" said $BMY's EVP & Chief Medical Officer https://twitter.com/i/web/status/2020869945924481264 https://twitter.com/i/web/status/2020869945924481264"
[X Link](https://x.com/PearlF/status/2020869945924481264) 2026-02-09T14:38Z [----] followers, [----] engagements
"@CJMacDonald @step @Beast @MrBeast Congratulations"
[X Link](https://x.com/PearlF/status/2020985928597258338) 2026-02-09T22:19Z [----] followers, [---] engagements
"@SamDavisEsq @A_May_MD Their Chief Legal Officer is ex Jones Day & their Chief Policy Officer is an attorney who worked for the DOJ and worked at the FDA for over [--] yrs. Maybe they assumed the current FDA would do nothing or would just send another letter like last year"
[X Link](https://x.com/PearlF/status/2020990755091689501) 2026-02-09T22:38Z [----] followers, [---] engagements
"@SamDavisEsq @A_May_MD They backed down really quickly on the oral pill though & maybe they were caught off guard by FDA's swift negative response & referral to DOJ within [--] hrs or so of Hims' announcement"
[X Link](https://x.com/PearlF/status/2021010989907423592) 2026-02-09T23:59Z [----] followers, [--] engagements
"Has the FDA commented the retraction notice [--] the leucovorin & autism study was published on Jan [--]. $GSK had stopped manufacturing it in '97 (for toxic side effects of chemotherapy.) HHS & FDA announced in Sept that leucovorin was receiving a label update for autism: "This action establishes the first FDA-recognized therapeutic for children with cerebral folate deficiency & autistic symptoms." The largest trial on leucovorin was just retracted. Now there's basically no causal signal leucovorin works in the published literature. The likelihood this will help with autism is falling."
[X Link](https://x.com/PearlF/status/2021338759002804364) 2026-02-10T21:41Z [----] followers, [----] engagements
"I started to read about Hawley/Warren bill to see if has potential solutions for reducing healthcare & drug spend in US & saw they told CBS News today that it's "Big Pharma" who "continue to gobble up every independent healthcare provider & pharmacy they can find." cc @mcuban"
[X Link](https://x.com/PearlF/status/2021360107125342527) 2026-02-10T23:06Z [----] followers, [----] engagements
"Moderna's seasonal investigational influenza vaccine mRNA-1010 has been submitted & accepted for review in the EU Canada & Australia $MRNA. Kennedy's FDA in the US officially refused to review the vaccine & "the U.S. Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) has notified the Company that it will not initiate a review of the biologics license application (BLA) for its investigational influenza vaccine mRNA-1010 and has issued a Refusal-to-File (RTF) letter. Moderna had exercised a Priority Review Voucher to facilitate a timely review of the"
[X Link](https://x.com/PearlF/status/2021367040158650627) 2026-02-10T23:33Z [----] followers, [----] engagements
"Moderna said as recently as August in a meeting before it submitted its application [--] approval of the vaccine "the FDA suggested that it would review the filing & assess issues with the comparator during that process." The EU Canada & Australia have all accepted $MRNA's application: The FDA has refused to accept an application from Moderna to review its first mRNA seasonal flu vaccine the company said. https://t.co/mBu4Up1Lh5 The FDA has refused to accept an application from Moderna to review its first mRNA seasonal flu vaccine the company said. https://t.co/mBu4Up1Lh5"
[X Link](https://x.com/PearlF/status/2021382892820050167) 2026-02-11T00:36Z [----] followers, [----] engagements
"Interesting update re: national governors' meeting:"
[X Link](https://x.com/PearlF/status/2021413119139119222) 2026-02-11T02:36Z [----] followers, [---] engagements
"Fox News wrote a story: https://www.foxnews.com/politics/national-governors-association-reportedly-cancels-meeting-trump-after-white-house-snubs-democrats https://www.foxnews.com/politics/national-governors-association-reportedly-cancels-meeting-trump-after-white-house-snubs-democrats"
[X Link](https://x.com/PearlF/status/2021414074253443578) 2026-02-11T02:40Z [----] followers, [--] engagements
"The U.S. Attorney is "Judge Jeanine" from Fox News. Her ex husband Albert received a pardon from the president"
[X Link](https://x.com/PearlF/status/2021427830538764690) 2026-02-11T03:35Z [----] followers, [---] engagements
"From Time Magazine's list of Time [---] Health honorees:"
[X Link](https://x.com/PearlF/status/2021812560966955475) 2026-02-12T05:04Z [----] followers, [--] engagements
"One more screenshot from Time Magazine's list of Time [---] Health honorees in 2026:"
[X Link](https://x.com/PearlF/status/2021813741419962436) 2026-02-12T05:08Z [----] followers, [--] engagements
"Johnson & Johnson announced last week that [-----] multiple myeloma/blood cancer patients globally have been treated with a $JNJ CAR-T cell therapy. J&J and Legend Biotech $LEGN received FDA approval for Carvykti in [----]. Link to J&J's writeup is in the reply: #mmsm #immunoonc"
[X Link](https://x.com/PearlF/status/2013646999422169112) 2026-01-20T16:17Z [----] followers, [---] engagements
"Merck & BMS alum and ex Checkmate Pharmaceuticals (acquired by Regeneron) Chief Medical Officer Dave Mauro joins clinical stage "TechBio" company @RecursionPharma as CMO. He starts 6/1. $RXRX Congrats 1/n https://ir.recursion.com/news-releases/news-release-details/recursion-appoints-david-mauro-md-phd-chief-medical-officer https://ir.recursion.com/news-releases/news-release-details/recursion-appoints-david-mauro-md-phd-chief-medical-officer"
[X Link](https://x.com/PearlF/status/1658494113753313287) 2023-05-16T15:26Z [----] followers, [----] engagements
"Clinical Trial Result Of The Year went to Karuna Therapeutics (now a Bristol Myers Squibb company) for "its pivotal Phase III trial of KarXT (xanomeline-trospium) in schizophrenia which showed impressive efficacy and differentiation from standard-of-care generic antipsychotics. KarXT is expected to be a first-in-class M1/M4-preferring muscarinic receptor agonist designed to preferentially stimulate muscarinic receptors in the central nervous system. Analysts deemed its efficacy comparable to prior antipsychotics but with a differentiated side effect profile. The judging panel also took note"
[X Link](https://x.com/PearlF/status/1788578900458553412) 2024-05-09T14:36Z [----] followers, [---] engagements
"FDA issued a notice yesterday that said do not use Cue Health's Covid-19 diagnostic tests for home & OTC use & not in patient care settings"due to increased risk of false test results." https://www.fda.gov/medical-devices/safety-communications/do-not-use-cue-healths-covid-19-tests-due-risk-false-results-fda-safety-communication https://www.fda.gov/medical-devices/safety-communications/do-not-use-cue-healths-covid-19-tests-due-risk-false-results-fda-safety-communication"
[X Link](https://x.com/PearlF/status/1790419095181054232) 2024-05-14T16:29Z [----] followers, [----] engagements
"Im at #CNSSummit2024 conf in Boston/Everett & the speakers are Bristol Myers Squibb EVP/Chief Medical Officer Samir Hirawat & former Karuna Therapeutics senior execs Steve Paul & Stephen Brennan talking w/ @CNSSummit chairman @akalali"
[X Link](https://x.com/PearlF/status/1856343274186809580) 2024-11-12T14:28Z [----] followers, [---] engagements
"Bristol Myers Squibb announced a collaboration w/Microsoft to advance AI-driven early detection of lung cancer using FDA-cleared radiology AI algorithms via $MSFT's Precision Imaging Network. Using lung cancer-specific AI workflows they said. Press release is in the reply"
[X Link](https://x.com/PearlF/status/2013637506139410838) 2026-01-20T15:39Z [----] followers, [----] engagements
"45% of major biopharma companies' data sciences leaders surveyed by BCG said they've seen "demonstrated proof-of- value" using generative AI for molecule design. 50% said they've started to use it routinely. (Surveyed incl AZ GILD PFE NVS MRK LLY SNY ABBV Roche Bayer). 5% had said it was in early pilots for them. The paper said "molecule design can involve a range of GenAI algorithms including generative adversarial networks recurrent neural networks variational autoencoders flow-based models & others." [--] data sciences leaders co-authored a paper to discuss how generative AI is reshaping"
[X Link](https://x.com/PearlF/status/2020648290669486581) 2026-02-08T23:57Z [----] followers, [----] engagements
"Adaptive clinical trial designs will have broader adoption across the industry in '26 said Daiichi Sankyo's global head of R&D Ken Takeshita. Lundbeck's EVP of R&D Johan Luthman said: "Advances in adaptive trial designs will mark the beginning of the end for rigid clinical trial phases blurring the boundaries between Phases I-IV. Instead of sequential steps integrated continuous development models will emerge with proactive real-time analytics converging dynamically with integration of safety efficacy post-marketing insights & real-world evidence." From Scrip's R&D predictions for '26 issue"
[X Link](https://x.com/PearlF/status/2020860263553966407) 2026-02-09T14:00Z [----] followers, [----] engagements
"Bristol Myers Squibb's EVP/CMO & Head of Development Cristian Massacesi said targeted protein degradation is poised to become the default therapeutic strategy for undruggable targets in '26. "Building on pioneering IMiD work advanced next-generation approaches such as CELMoD agents ligand-directed degraders& degrader antibody conjugates continue to transform outcomes in blood cancers & beyond as they are systematically integrated into discovery & development pipelines." https://twitter.com/i/web/status/2020869141767372965 https://twitter.com/i/web/status/2020869141767372965"
[X Link](https://x.com/PearlF/status/2020869141767372965) 2026-02-09T14:35Z [----] followers, [----] engagements
""Recent pivotal trials & expansion into targets like BCL6 & GSPT1 indicate a tipping point that will reshape asset selection & regulatory dialogue across biopharma" said Bristol Myers Squibb's EVP & Chief Development Officer Cristian Massacesi $BMY"
[X Link](https://x.com/PearlF/status/2020871581254234216) 2026-02-09T14:45Z [----] followers, [----] engagements
"Moderna's president Stephen Hoge said Blackstone $BX had invested $750M in the development of Modernas $MRNA flu vaccine including a 40700-person clinical trial. CNN story today: as recently as August FDA's meeting gave no indication they would refuse their application for review. EU Canada & Australia accepted the submitted application & are reviewing it: NEW: The F.D.A. refused to accept an application from Moderna for its mRNA flu vaccine. Its reason: The agency did not think Moderna compared the new vaccine to one of the best flu shots available. The company spent $750M+ on a [-----] person"
[X Link](https://x.com/PearlF/status/2021386685678858397) 2026-02-11T00:51Z [----] followers, [----] engagements
"SF-based Maplight Therapeutics received $8.1M from @MichaelJFoxOrg 2undertake "investigation of brain circuits & mechanisms that are responsible for triggering psychiatric symptoms in Parkinsons disease" & potential therapeutic strategies incl depression https://www.prnewswire.com/news-releases/maplight-therapeutics-receives-8-1-million-for-parkinsons-disease-research-301180711.html https://www.prnewswire.com/news-releases/maplight-therapeutics-receives-8-1-million-for-parkinsons-disease-research-301180711.html"
[X Link](https://x.com/PearlF/status/1333461705049976833) 2020-11-30T17:23Z [----] followers, [--] engagements
"Sanofi has now called off the deal w/Maze Therapeutics as a result of the FTC's injunction: What happens to the potential clinical trial for Pompe disease patients now https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html Wow FTC is intervening in a small biotech collab w/ a French pharma that could potentially help patients living w/ Pompe disease. Biotech companies need collabs w/large cos & the $ to develop new drugs: https://t.co/ASCRcKtxU7"
[X Link](https://x.com/PearlF/status/1734335028627116359) 2023-12-11T22:11Z [----] followers, [----] engagements
"I missed the @FierceBiotech @JamesPharma story earlier today about @ClimbBio & their deal for the preclinical IgA antibody. It's not only large companies who are doing cash upfront deals & below is the link to the story 1/n"
[X Link](https://x.com/PearlF/status/1877477279711862799) 2025-01-09T22:07Z [----] followers, [----] engagements
"Here's the link to Fierce Biotech story I reference above: https://www.fiercebiotech.com/biotech/climb-bio-ascends-eliem-legacy-9m-upfront-deal-preclinical-iga-antibody https://www.fiercebiotech.com/biotech/climb-bio-ascends-eliem-legacy-9m-upfront-deal-preclinical-iga-antibody"
[X Link](https://x.com/PearlF/status/1877478342510674383) 2025-01-09T22:11Z [----] followers, [---] engagements
"More US clinical trials infrastructure advice from Novartis/Gal $NVS: "Establish guidelines on appropriate costs of trial participation" & "Adopt & adapt best business practices streamlining contract templates and implementing efficient regional review mechanisms for multi-center trials." https://twitter.com/i/web/status/2015849540763410541 https://twitter.com/i/web/status/2015849540763410541"
[X Link](https://x.com/PearlF/status/2015849540763410541) 2026-01-26T18:09Z [----] followers, [----] engagements
"More on FDA from story below: "In November Prasad sent an email alleging that [--] childrens deaths were linked to Covid vaccines but he has yet to publicly produce data to back up the claim. The email also said that staff who disagreed with his operating principles should submit their resignations." New from me: The Moderna decision is part of a pattern of regulatory U-turns and overruling of FDA staff by Prasad a Covid-vaccine critic 🎁🔗https://t.co/BwzK5Fnvt5 New from me: The Moderna decision is part of a pattern of regulatory U-turns and overruling of FDA staff by Prasad a Covid-vaccine"
[X Link](https://x.com/PearlF/status/2021780623799488575) 2026-02-12T02:57Z [----] followers, 10.3K engagements
"It's also not true that RFK is "pivoting away from vaccines" especially since just this week a political appointee at FDA who works for him overruled FDA career reviewers to prevent a seasonal flu vaccine from being reviewed that EU Canada & Australia accepted for review. Heres an unlocked to WSJ story last nigh. The political appointee sent a letter to Moderna that the FDA refused to review the vaccine: https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=So4baV&reflink=desktopwebshare_permalink"
[X Link](https://x.com/PearlF/status/2021978699680080193) 2026-02-12T16:04Z [----] followers, [---] engagements
"@jordixiol Did they hire a salesforce & spend money and time preparing for launch a year earlier than they needed to because of feedback they were given during the FDAs new voucher review process"
[X Link](https://x.com/PearlF/status/2022440379409195331) 2026-02-13T22:38Z [----] followers, [---] engagements
"@grok @TAT001122TAT @jakescottMD Was Moderna's flu vaccine application to FDA incomplete"
[X Link](https://x.com/PearlF/status/2022636194379583659) 2026-02-14T11:37Z [----] followers, [--] engagements
"@grok @TAT001122TAT @jakescottMD Hi Grok thanks for the responses to this question. An associate professor of law @david__simon sent the below information from Cornell Law School's website on [--] U.S. Code 706: https://www.law.cornell.edu/uscode/text/5/706 https://www.law.cornell.edu/uscode/text/5/706"
[X Link](https://x.com/PearlF/status/2022686250696896793) 2026-02-14T14:55Z [----] followers, [--] engagements
"An update below on clinical stage biotech Maze Therapeutics @MazeInBiotech who reported positive first-in-human data [--] months ago from Phase [--] clinical trial evaluating MZE829 as a potential treatment for APOL1 kidney disease (AKD). Based in South San Francisco: Meet the company angling to be the Bay Area's first biotech IPO of [----] https://t.co/JkurssNoP6 via @SFBusinessTimes Meet the company angling to be the Bay Area's first biotech IPO of [----] https://t.co/JkurssNoP6 via @SFBusinessTimes"
[X Link](https://x.com/PearlF/status/1876770626620236016) 2025-01-07T23:19Z [----] followers, [---] engagements
"Not just new medicines. FDA will likely also prevent updated flu vaccines for the fall in the UStaking away the choice to get a flu vaccine in the US in September. If you don't want to get a flu shot don't get one but don't prevent others who want one from getting the shot. The complete stunner here is at no point in any of this did anybody say that it was not adequate. An unacceptable level of uncertainty for innovators to bring new medicines to patients. https://t.co/8n3Sxn9ufk The complete stunner here is at no point in any of this did anybody say that it was not adequate. An unacceptable"
[X Link](https://x.com/PearlF/status/2021401124943917461) 2026-02-11T01:49Z [----] followers, [----] engagements
"About Rick Pazdur: the founding director of the FDA's Oncology Center of Excellence explained to @l_e_whyte WSJ why he resigned from FDA in December h/t filmmaker @WhitStillman. An unlocked link to the interview is in the reply: $XBI $IBB #immunooncology"
[X Link](https://x.com/PearlF/status/2022509060269261227) 2026-02-14T03:11Z [----] followers, [----] engagements
"Here's an unlocked link to Rick Pazdur's interview w/ WSJ's published tonight @l_e_whyte: #oncology #immunooncology https://www.wsj.com/health/healthcare/top-fda-scientist-explains-why-he-quit-after-getting-a-promotion-from-rfk-jr-2c85a510st=neKRLd&reflink=desktopwebshare_permalink https://www.wsj.com/health/healthcare/top-fda-scientist-explains-why-he-quit-after-getting-a-promotion-from-rfk-jr-2c85a510st=neKRLd&reflink=desktopwebshare_permalink"
[X Link](https://x.com/PearlF/status/2022511056204206255) 2026-02-14T03:19Z [----] followers, [---] engagements
"One of HHS Secretary Kennedy's spokespeople commented: to WSJ: "Dr. Makarywith his clinical experience in treating cancer patientsleads the agency with a profound sense of urgency in delivering cures to the American people.""
[X Link](https://x.com/PearlF/status/2022516192972513646) 2026-02-14T03:40Z [----] followers, [---] engagements
"Gr8 to read abt another Tillman Gerngross/Polaris innovative co in NH Kevin Isett is CEO/co-founder. OrbiMed in too https://x.com/BentheFidler/status/629275944822382592 Ex-Adimab Execs Startup Avitide Gets $7.6M For Drug Purifying Tech http://t.co/7nwULV9SE2 #startups #biotech https://x.com/BentheFidler/status/629275944822382592 Ex-Adimab Execs Startup Avitide Gets $7.6M For Drug Purifying Tech http://t.co/7nwULV9SE2 #startups #biotech"
[X Link](https://x.com/PearlF/status/629277874705596416) 2015-08-06T13:08Z [----] followers, [--] engagements
"@angelicalavito I think the Nashville airport has a clinic too I think I remember seeing one. Sounds like a good idea"
[X Link](https://x.com/PearlF/status/1049302966707126273) 2018-10-08T14:18Z [----] followers, [--] engagements
"Provocative post by @MassBio on the drug pricing debate & where is high % $ going The Fortune [--] list includes health insurers United Anthem Aetna; PBMs CVS Health & Express Scripts; drug distributors McKesson AmerisourceBergen & Cardinal Health. http://bit.ly/2Bx264c http://bit.ly/2Bx264c"
[X Link](https://x.com/PearlF/status/1095678969792397314) 2019-02-13T13:39Z [----] followers, [--] engagements
"The Bristol Myers Squibb-Pfizer Alliance is partnering with @fitbit "to develop 'educational content and guidance' that will help device owners recognize if they are at risk of atrial fibrillation as well as to seek appropriate support and diagnosis of the condition." 1/3 $PFE"
[X Link](https://x.com/PearlF/status/1184910726571462656) 2019-10-17T19:15Z [----] followers, [--] engagements
"Article said the specifics of the program are still under development but here's what the partners revealed: "It will rely on the atrial fibrillation detection feature that Fitbit is still developing for their wearables. Once this algorithm has been fully tested submitted to 2/3"
[X Link](https://x.com/PearlF/status/1184910727339020289) 2019-10-17T19:15Z [----] followers, [--] engagements
"@vishalgulati_ @OmicsOmicsBlog @LifeSciVC It sounds like an important metric to evaluate because timelines and failure rates on average haven't improved over [--] to [--] yrs. Some exceptions include Agios and Vertex. Pharma companies have been working with some form of AI for [--] years"
[X Link](https://x.com/PearlF/status/1207005779666096129) 2019-12-17T18:32Z [----] followers, [--] engagements
"New KRAS-focused drug licensing deal: Verastem Oncology pays $3M upfront to Tokyo-based Chugai Pharma for worldwide development & sales rights to RAF/MEK inhibitor CH5126766 (CKI27) which is in tests for KRAS mutant solid tumors $VSTM #oncology http://bit.ly/2QBas2q http://bit.ly/2QBas2q"
[X Link](https://x.com/PearlF/status/1215354758015463424) 2020-01-09T19:28Z [----] followers, [--] engagements
"Darren Carroll left Eli Lilly in Aug & he was SVP & VP Business Development ('10-'19) & VP New Ventures ('05-'10) incl head Lilly Ventures ($200M VC fund) & Lilly Asian Ventures. [--] yrs at Lilly. He has now joined @PolarisVC in Boston as partner. Congrats https://bwnews.pr/37VxjeO https://bwnews.pr/37VxjeO"
[X Link](https://x.com/PearlF/status/1215606689132621824) 2020-01-10T12:09Z [----] followers, [--] engagements
"Last month I mentioned that @polarisvc announced they recruited former Kleiner Perkins partner & former Atara Biotherapeutics CEO Isaac Ciechanover as a partner in their San Francisco office. https://bwnews.pr/2PmUW8B https://bwnews.pr/2PmUW8B"
[X Link](https://x.com/PearlF/status/1215608156023349248) 2020-01-10T12:15Z [----] followers, [--] engagements
"@ldtimmerman Hi Luke- consider doing the next Tweetchat w/@millennium_US CEO Deborah Dunsire. I know she's on Facebook"
[X Link](https://x.com/PearlF/status/121618805741977600) 2011-10-05T16:12Z [----] followers, [--] engagements
"@ldtimmerman @masterlongevity Did he discuss GVs investment in EQRx on the panel #JPM20"
[X Link](https://x.com/PearlF/status/1217222679125807106) 2020-01-14T23:11Z [----] followers, [--] engagements
"@WyomingScience I don't know if she supports open borders that admin deported a lot of ppl. I saw that she made a negative comment elsewhere about Bernie doing press with Marianne Williamson today because MW is an anti-vaxxer & he might be supporting anti-vaxxers now too (if he didn't before)"
[X Link](https://x.com/PearlF/status/1232058263279149057) 2020-02-24T21:42Z [----] followers, [--] engagements
"@ldtimmerman @OtelloVC What's also scary is that most of the rural areas probably don't have much intensive care capacity & staffing. Patient zero in NJ (not rural area) shared his harrowing story of doctors not knowing how to treat him & he almost died at age [--]. He's Chinese & had contacts advise him"
[X Link](https://x.com/PearlF/status/1245123089287065600) 2020-03-31T22:57Z [----] followers, [--] engagements
"@daviesbj @ldtimmerman https://www.businessinsider.com/trump-doctor-health-letter-who-wrote-it-2018-5 https://www.businessinsider.com/trump-doctor-health-letter-who-wrote-it-2018-5"
[X Link](https://x.com/PearlF/status/1248728790169198595) 2020-04-10T21:45Z [----] followers, [--] engagements
"Bay Area-based rare disease drug developer Ultragenyx received their 2nd FDA drug approval in [--] weeks. New approved drug is Dojolvi for the treatment of a rare set of genetic metabolic disorders which can occur in newborns. $RARE https://bit.ly/2AipOn8 https://bit.ly/2AipOn8"
[X Link](https://x.com/PearlF/status/1278336947484872707) 2020-07-01T14:37Z [----] followers, [--] engagements
"@zakkohane Have you seen this news about Tesla and CureVac https://endpts.com/tesla-chief-elon-musk-teams-up-with-covid-19-player-curevac-to-build-rna-microfactories/ https://endpts.com/tesla-chief-elon-musk-teams-up-with-covid-19-player-curevac-to-build-rna-microfactories/"
[X Link](https://x.com/PearlF/status/1278680448235982850) 2020-07-02T13:22Z [----] followers, [--] engagements
"Genome editing expert TJ Cradick @NucleaseLab has joined Excision BioTherapeutics as Chief Scientific Officer. He was previously Head of Genome Editing at CRISPR Therapeutics for close to [--] yrs. Congrats https://bit.ly/31lmr8r https://bit.ly/31lmr8r"
[X Link](https://x.com/PearlF/status/1290980052876828673) 2020-08-05T11:56Z [----] followers, [--] engagements
"@ldtimmerman @skathire Why aren't they being held accountable for plan that could have been implemented in April & "went poof into thin air" because they didn't want to help NY NJ WA CA & states considered "blue states." https://www.vanityfair.com/news/2020/07/how-jared-kushners-secret-testing-plan-went-poof-into-thin-air https://www.vanityfair.com/news/2020/07/how-jared-kushners-secret-testing-plan-went-poof-into-thin-air"
[X Link](https://x.com/PearlF/status/1293997505068314629) 2020-08-13T19:47Z [----] followers, [--] engagements
"MIT biology professor and pioneering researcher of cancer cell metabolism Matthew Vander Heiden @mvh_lab has been named the next director of MITs Koch Institute for Integrative Cancer Research @kochinstitute effective April [--]. Congrats https://news.mit.edu/2021/matthew-vander-heiden-koch-institute-0331 https://news.mit.edu/2021/matthew-vander-heiden-koch-institute-0331"
[X Link](https://x.com/PearlF/status/1377315691171360771) 2021-03-31T17:43Z [----] followers, [--] engagements
""While serving as director Vander Heiden plans to continue working as a medical oncologist at the Dana-Farber Cancer Institute where he treats prostate cancer patients." https://www.bostonglobe.com/2021/03/31/business/matthew-vander-heiden-named-new-director-mits-koch-institute-integrative-cancer-research/ https://www.bostonglobe.com/2021/03/31/business/matthew-vander-heiden-named-new-director-mits-koch-institute-integrative-cancer-research/"
[X Link](https://x.com/PearlF/status/1377317478896967681) 2021-03-31T17:50Z [----] followers, [--] engagements
"@sububoston @srikosuri @aaronmring I don't know where that information is from but see the below thread: https://x.com/DrSidMukherjee/status/1389243618360188931 I got a thousand replies to my questions but not any that I needed/wanted. [--]. I know the lab data. do we have HUMAN data on AZ/Covaxin vaccine effectiveness against B1618 etc in India [--]. And why aren't any of these studies in PEER REVIEWED JOURNALS https://x.com/DrSidMukherjee/status/1389243618360188931 I got a thousand replies to my questions but not any that I needed/wanted. [--]. I know the lab data. do we have HUMAN data on"
[X Link](https://x.com/PearlF/status/1390137882438815745) 2021-05-06T02:54Z [----] followers, [--] engagements
"VC @UcianeScarlett left Oxford Sciences Innovation & joined @MPMCapital as Principal last month. Congrats"
[X Link](https://x.com/PearlF/status/1450440124303646721) 2021-10-19T12:34Z [----] followers, [--] engagements
"Emanuele Ostuni has left Novartis Oncology to join a stealth early stage biotech focused on radioligand therapeutics as CEO + 1st full-time employee. He was prev NVS Oncology head of cell & gene therapy for Europe for [--] yrs Sandoz prior. He co-founded Enumeral Biomedical in '09"
[X Link](https://x.com/PearlF/status/1488609437870964741) 2022-02-01T20:25Z [----] followers, [--] engagements
"Novartis announced license option agreement w/ gene therapy company Voyager Therapeutics for [--] capsids to use in potential gene therapies for neurological diseases w/option to access capsids for [--] other targets. VYGR's next-gen AAV platform called https://www.novartis.com/news/media-releases/novartis-voyager-therapeutics-reach-license-option-agreement-next-generation-gene-therapy-vectors-neurological-diseases https://www.novartis.com/news/media-releases/novartis-voyager-therapeutics-reach-license-option-agreement-next-generation-gene-therapy-vectors-neurological-diseases"
[X Link](https://x.com/PearlF/status/1501242676464738311) 2022-03-08T17:05Z [----] followers, [--] engagements
"More on Novartis & Voyager Therapeutics deal. Glenn Pierce is VYGR's interim CSO & Michael Higgins is interim CEO https://endpts.com/novartis-takes-a-gamble-on-voyagers-new-aav-tech-inks-1-5b-gene-therapy-discovery-pact/ https://endpts.com/novartis-takes-a-gamble-on-voyagers-new-aav-tech-inks-1-5b-gene-therapy-discovery-pact/"
[X Link](https://x.com/PearlF/status/1501243510103724033) 2022-03-08T17:08Z [----] followers, [--] engagements
"Venrock & @BRobertsVC led $20M B round in next-gen PBM startup SmithRx. SF-based Founder & CEO is Anthem & Collective Health alum Jake Frenz. CVS/Caremark Cigna/ES & United are "Big Three" w/80% of market & "control drug prices." Story by @erinbrodwin https://www.axios.com/venrock-seriesb-smithrx-20-million-fbe764bd-ce04-478d-8af4-80154d375c19.html https://www.axios.com/venrock-seriesb-smithrx-20-million-fbe764bd-ce04-478d-8af4-80154d375c19.html"
[X Link](https://x.com/PearlF/status/1501992850216656897) 2022-03-10T18:46Z [----] followers, [--] engagements
"It might be early but I think it's exciting 2c a biotech VC firm Venrock invest in a next-generation PBM & potentially be part of a solution [--] disrupt status quo of Caremark Cigna & United using combined 80% market share to manipulate drug prices increase OOP & harm patients"
[X Link](https://x.com/PearlF/status/1501997086962761735) 2022-03-10T19:03Z [----] followers, [--] engagements
"@pandemona @goldman They're also the same firm that said they hadn't hired female VC partners because they couldn't find women that met their "standards." Moritz interview with @emilychangtv in '15: https://www.youtube.com/watchv=1i-RXdi15Bg https://www.youtube.com/watchv=1i-RXdi15Bg"
[X Link](https://x.com/PearlF/status/1594398741263417344) 2022-11-20T18:34Z [----] followers, [--] engagements
"FDA approved the 1st echinocandin drug in a decade--@CidaraThera & @MelintaTx announced that antifungal Rezzayo received approval under priority review for candidemia & invasive candidiasis in adults. Cidara's CEO is @jefflstein. Melinta's CEO is Christine Miller. Congrats Cidara is also conducting a Phase III trial w/Rezzayo for the prevention of invasive fungal diseases in adults undergoing allogeneic blood & marrow transplantation. Story by @KatherineMLewin https://endpts.com/fda-approves-cidaras-rezzayo-as-antifungal-treatment-for-candidemia-and-invasive-candidiasis/"
[X Link](https://x.com/PearlF/status/1638871785130151937) 2023-03-23T11:54Z [----] followers, [----] engagements
"Here's the press release w/FDA approval news for $CDTX & $MLNT and antifungal drug Rezzayo: https://www.businesswire.com/news/home/20230322005767/en/Cidara-Therapeutics-and-Melinta-Therapeutics-Announce-FDA-Approval-of-REZZAYO%E2%84%A2-rezafungin-for-injection-for-the-Treatment-of-Candidemia-and-Invasive-Candidiasis https://www.businesswire.com/news/home/20230322005767/en/Cidara-Therapeutics-and-Melinta-Therapeutics-Announce-FDA-Approval-of-REZZAYO%E2%84%A2-rezafungin-for-injection-for-the-Treatment-of-Candidemia-and-Invasive-Candidiasis"
[X Link](https://x.com/PearlF/status/1638872616034287617) 2023-03-23T11:57Z [----] followers, [---] engagements
"RIP to the archive of articles on the life sciences healthcare & technology industries across major hub cities in the US that used to be covered by media company Xconomy. Informa acquired Xconomy & it looks like the archives & links to stories are no longer easily findable online"
[X Link](https://x.com/PearlF/status/1638891094795595777) 2023-03-23T13:11Z [----] followers, [----] engagements
"Sanofi & Regeneron's Dupixent could also be the 1st biologic medicine to treat COPD/chronic obstructive pulmonary disease. Phase [--] data published in NEJM yesterday. 1st advance in COPD in close to [--] yrs Sanofi CEO said. Story by @AndrewE_Dunn w/ contributed reporting from @ArmstrongDrew https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/ https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/ https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/"
[X Link](https://x.com/PearlF/status/1660703031980072961) 2023-05-22T17:43Z [----] followers, [----] engagements
"Sanofi and Regeneron are also co-developing itepekimab an IL-33 antibody with a readout planned in [----] testing the drug in combination with Dupixent for COPD patients. More on this & the immunology pipeline in the above story"
[X Link](https://x.com/PearlF/status/1660703500156665856) 2023-05-22T17:45Z [----] followers, [---] engagements
"@AppleHelix And the personal relationship they have to say the least"
[X Link](https://x.com/PearlF/status/1668722349930102786) 2023-06-13T20:49Z [----] followers, [----] engagements
"@AppleHelix It turns out even the companies she co-founded have a connection to her father since they are Polaris Partners portfolio companies according to the Stat story. Her dad has a long history with Polaris. Polaris is also known to hire new VCs who are related to other VCs at the firm"
[X Link](https://x.com/PearlF/status/1668731422918561794) 2023-06-13T21:25Z [----] followers, [----] engagements
"Other significant Texas biotech acquisitions/exits incl Dallas-founded AveXis acquired by Novartis in $8.7B deal in '18 Dallas-based Peloton Therapeutics (not the bike) acquired by Merck in '19 for $1.05B in cash & additional $1.15B if milestones met Houston-based Tanox acquired by Genentech in '06 for $919M Fort Worth-based Encore Vision bought by Novartis/Alcon for $375M in cash & additional $90M if milestones met Biogen to acquire Plano Texas-based Reata Pharmaceuticals in cash deal w/enterprise value of $7.3B. Largest M&A transaction in BIIB's history eclipsing '03 merger with Idec"
[X Link](https://x.com/PearlF/status/1684914886902415360) 2023-07-28T13:13Z [----] followers, 10K engagements
"Supreme Court temporarily blocked a nationwide settlement with OxyContin maker Purdue Pharma to emerge from bankruptcy as a different entity that would shield members of the Sackler family who own the company from civil lawsuits over the toll of opioids. https://apnews.com/article/supreme-court-opioid-crisis-purdue-bankruptcy-bd417e036d9f6db4b2916fdfbdb56252 https://apnews.com/article/supreme-court-opioid-crisis-purdue-bankruptcy-bd417e036d9f6db4b2916fdfbdb56252"
[X Link](https://x.com/PearlF/status/1689765275728556032) 2023-08-10T22:26Z [----] followers, [---] engagements
"News below on 1st-ever in vivo CRISPR-based gene editing therapy cleared by FDA to enter Phase [--] trials. One step closer to being the 1st single-dose treatment for rare & fatal genetic disease ATTR amyloidosis. Intellia Tx founded in [----] & NTLA-2001 trial collab with Regeneron We did it FDA IND clearance of NTLA-2001 Im so proud of our team. Congrats to all A big thank you to our clinical trial participants and sites as well as our investigators who are contributing to the advancement of our therapies. The future looks bright #OneIntellia We did it FDA IND clearance of NTLA-2001 Im so proud"
[X Link](https://x.com/PearlF/status/1714709433173848189) 2023-10-18T18:26Z [----] followers, [---] engagements
"In just [--] yrs base editing has moved from concept to [--] Phase I clinical studies incl BEAM-101 & [---] (@BeamTx) VERVE-101 (@VerveTx ) BRL-103 (Bioray in China) & [--] CAR-T trials led by Waseem Qasim (University College of London) said @davidrliu at #ESGCT2023 h/t @KevinADavies Its easy to publish papers using poorly chosen guide RNAs & older-generation editing tools. Scientists should strive to use currently available editing reagents in such studies- said @davidrliu during #esgct2023 keynote in Brussels h/t @KevinADavies tweets Its easy to publish papers using poorly chosen guide RNAs &"
[X Link](https://x.com/PearlF/status/1717142004008644918) 2023-10-25T11:32Z [----] followers, [----] engagements
"Amgen plans to lay off [---] workers at Horizon Therapeutics mostly in Deerfield IL following Amgens acquisition of Horizon [--] wks ago said @chicagotribune. Horizon had [---] of [----] employees based in Deerfield at time of sale. 20% of Horizon 2b laid off https://www.chicagotribune.com/business/ct-biz-horizon-layoffs-amgen-acquisition-20231024-2q3xnax74bf7ze7qieqjsxg2ie-story.html https://www.chicagotribune.com/business/ct-biz-horizon-layoffs-amgen-acquisition-20231024-2q3xnax74bf7ze7qieqjsxg2ie-story.html"
[X Link](https://x.com/PearlF/status/1717149409287217392) 2023-10-25T12:01Z [----] followers, [---] engagements
"Philadelphia-based rare genetic disease biotech Aro Biotherapeutics raised $41.5M B led by Cowen Healthcare Investments w/participation from J&J Innovation/JJDC Northpond Healthcap & BVF https://www.arobiotx.com/aro-bio-secures-41m-series-b-financing https://www.arobiotx.com/aro-bio-secures-41m-series-b-financing"
[X Link](https://x.com/PearlF/status/1729648178046083389) 2023-11-28T23:47Z [----] followers, [----] engagements
"Biotech VC @UcianeScarlett PhD of MPM Capital will discuss her career trajectory & answering Q&A today at 5:00 PM ET on @thebiotechclub Zoom below. Prior to MPM she was a VC at Atlas & Oxford Sciences Enterprise. Prior to that she was business development dir at Compass Tx Do you want to learn how to navigate a high-impact career in life sciences If so please join us for a conversation with @UcianeScarlett from @MPMCapital tomorrow November 29th at 5pm to learn about pursing a career in venture capital and biotech investment https://t.co/m0HnDSkUWX Do you want to learn how to navigate a"
[X Link](https://x.com/PearlF/status/1729907060546981998) 2023-11-29T16:55Z [----] followers, [----] engagements
"39% of biotech organizations report anticipating searching for executive talent. 17% anticipate using fractiona executives (outsourced as-needed or part-time execs)"
[X Link](https://x.com/PearlF/status/1750608565528629450) 2024-01-25T19:56Z [----] followers, [---] engagements
"Vertex plans to buy Seattle-based Alpine Immune Sciences$4.9B in cash incl investigational drug entering Phase [--] that's shown promise in treating IgA nephropathy autoimmune disorder of the kidney that can lead to end-stage renal disease & affects [------] people in US $ALPN $VRTX Congrats to all involved https://twitter.com/i/web/status/1778164597565825410 https://twitter.com/i/web/status/1778164597565825410"
[X Link](https://x.com/PearlF/status/1778164597565825410) 2024-04-10T20:54Z [----] followers, [----] engagements
"Here's the link to the @statnews story by @matthewherper $VRTX $ALPN https://www.statnews.com/2024/04/10/vertex-to-buy-alpine-immune-sciences/ https://www.statnews.com/2024/04/10/vertex-to-buy-alpine-immune-sciences/"
[X Link](https://x.com/PearlF/status/1778164967193075894) 2024-04-10T20:55Z [----] followers, [---] engagements
"The award for Clinical Research Team Of The Year went to Agios Pharmaceuticals team for the [---] ENERGIZE trial of mitapivat for thalassemia $AGIO. "The team exceeded enrollment targets and completed the pivotal Phase III study ahead of schedule. Proactively engaging with patient advocacy groups they ensured protocols reflected patient challenges culminating in historic results: meeting primary and secondary endpoints and demonstrating mitapivats potential to transform thalassemia treatment the firm said adding that their cross-functional collaboration has set a new standard in rare disease"
[X Link](https://x.com/PearlF/status/1788580218044551534) 2024-05-09T14:42Z [----] followers, [----] engagements
"SF-based extracellular protein degradation biotech & Lilly collaborator @LyciaTx is prepping to enter clinical trials w/ $106.6M C round led by Venrock w/participation from Versant RTW Cowen & more. Co-founder is Nobel laureate @CarolynBertozzi CEO is Aetna Wun Trombley. Congrats https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/ https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/ https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/"
[X Link](https://x.com/PearlF/status/1790106256859893942) 2024-05-13T19:46Z [----] followers, [----] engagements
""The FDA issued a Warning Letter to Cue Health on May [--] [----] after an inspection revealed the company made changes to these tests and these changes reduced the reliability of the tests.""
[X Link](https://x.com/PearlF/status/1790419551726743672) 2024-05-14T16:31Z [----] followers, [---] engagements
"With Calico's announcement today it looks like FDA's Operation Warp Speed program for rare diseases picked their initial [--] candidates: Moderna Denali Therapeutics Larimar Therapeutics Grace Science Neurogene Myrtelle & now Calico. Operation Warp Speed for Covid in '20 had 8"
[X Link](https://x.com/PearlF/status/1799193767297355832) 2024-06-07T21:36Z [----] followers, [----] engagements
""Recent discoveries have highlighted the role of microglial signaling & neuroinflammation in neurodegenerative diseases. TREM2 is a well credentialed microglia target in this context said Erik Wallstroem $SNY Sanofi's Global Head of Neurology Development. $VIGL In connection with the equity investment Vigil has granted Sanofi the exclusive right of first negotiation for an exclusive license grant or transfer of rights to research develop manufacture and commercialize the Vigils small molecule TREM2 agonist program including its clinical candidate VG-3927. VG-3927 is currently being evaluated"
[X Link](https://x.com/PearlF/status/1806291459680657473) 2024-06-27T11:40Z [----] followers, [----] engagements
"@Jasonmmast Interesting. if the data isn't very good will patients & parents (& payers) wait a little longer for Solid or Regenxbio"
[X Link](https://x.com/PearlF/status/1808129686767079573) 2024-07-02T13:24Z [----] followers, [--] engagements
"I wanted to note that the PBM situation became worse for consumers & independent pharmacies in recent yrs after the '18 mergers of CVS & Aetna (CVS/Aetna/Caremark) and Cigna & Express Scripts. (Cigna/Express Scripts/Accredo). Members of previous cabinet like Pompeo have been publicly speaking out against the FTC interim report https://twitter.com/i/web/status/1811116203345334359 https://twitter.com/i/web/status/1811116203345334359"
[X Link](https://x.com/PearlF/status/1811116203345334359) 2024-07-10T19:12Z [----] followers, [---] engagements
"This is @ADeAngelis_bio's story about Curie Bio when they announced their 2nd or 3rd fund [--] wks ago. If you're a scientist starting a company or thinking about itthey're a good group to talk to: https://www.statnews.com/2024/06/26/curie-bio-accelerator-new-fund/ https://www.statnews.com/2024/06/26/curie-bio-accelerator-new-fund/"
[X Link](https://x.com/PearlF/status/1811539614022135938) 2024-07-11T23:14Z [----] followers, [---] engagements
"This is @GabrielleMasso9's story in @FierceBiotech about Curie Bio also from [--] wks ago (open access): https://www.fiercebiotech.com/biotech/alexis-borisy-founded-vc-raises-380m-early-stage-biotechs https://www.fiercebiotech.com/biotech/alexis-borisy-founded-vc-raises-380m-early-stage-biotechs"
[X Link](https://x.com/PearlF/status/1811540469014200641) 2024-07-11T23:17Z [----] followers, [---] engagements
"New addition to clinical stage biotech's mgmt team incl EMD Serono & Alpine Immune Sciences alum Christof Marr as SVP Commercial.@VedantaBio is progressing Phase [--] & [--] trials for diseases below w/product engine incl large library of bacteria isolated from human microbiome $PRTC Today our Founded Entity @VedantaBio announced the expansion of its leadership team as the company progresses its Phase [--] trial for #Cdiff and Phase [--] trial for #ulcerativecolitis and builds its commercial function https://t.co/iyxH8gpk0B https://t.co/XeImsW0owt Today our Founded Entity @VedantaBio announced the"
[X Link](https://x.com/PearlF/status/1816603470822056090) 2024-07-25T22:36Z [----] followers, [---] engagements
"Royalty Pharma $RPRX announced in May that they had acquired an interest in Agios $AGIO royalty on Serviers vorasidenib for $905M in upfront cash contingent on FDA's approval of vorasidenib. The 1st targeted therapy in IDH-mutant glioma a progressive & incurable brain tumor"
[X Link](https://x.com/PearlF/status/1820938630916964546) 2024-08-06T21:42Z [----] followers, [----] engagements
"Royalty Pharma said at the time (May '24) that they projected $1B in peak sales annually for vorasidenib in US w/ potential to generate royalties exceeding $150M annually: https://www.royaltypharma.com/news/royalty-pharma-and-agios-pharmaceuticals-enter-into-vorasidenib-royalty-agreement-for-905-million/ https://www.royaltypharma.com/news/royalty-pharma-and-agios-pharmaceuticals-enter-into-vorasidenib-royalty-agreement-for-905-million/"
[X Link](https://x.com/PearlF/status/1820939128571068595) 2024-08-06T21:44Z [----] followers, [---] engagements
"Clinical stage gene editing biotech focused on CRISPR-based therapies recruited Alexion & Shire alum Maria Natale to be $NTLA's SVP Commercial. Most recently she was Galderma's Global Franchise Head of Immunology. At Shire/Takeda she was the US launch lead for hereditary angiodema drug Takhzyro & was the global commercial of the hematology franchise. You can read more about her hematology experience at Baxalta/Baxter & at the other employers on the website Excited to announce the newest member of our leadership team Maria Natale senior vice president of Commercial. With over [--] years of"
[X Link](https://x.com/PearlF/status/1826220234002383357) 2024-08-21T11:30Z [----] followers, [---] engagements
"Anthems demand for $ is highly unusual & seems weird said @jlevinscherz managing dir at Willis Towers Watson @WTWcorporate who advises employers on health coverage. Ive never heard of a carrier billing a physician for procedures or a medicine that was provided by someone else. https://twitter.com/i/web/status/1835479467520655422 https://twitter.com/i/web/status/1835479467520655422"
[X Link](https://x.com/PearlF/status/1835479467520655422) 2024-09-16T00:43Z [----] followers, [----] engagements
"This sounds like fun at the JPM healthcare conference in Jan but I also hope action has been taken since Jan '24 on making sure that nursing moms attending the conference (incl journalists) have a better experience this time. See below for @statnews story by @TaraBannow 1/n This year among a sea of black suits we are going to add a splash of color. You dont have to be one of the almost [---] #BiotechCEOSisters to wear pink at #JPM2025. Pink ties socks and scarves also welcome Tuesday January 14th [----] https://t.co/foiY5vk3Xe This year among a sea of black suits we are going to add a splash of"
[X Link](https://x.com/PearlF/status/1845585912006070544) 2024-10-13T22:02Z [----] followers, [----] engagements
"This is the story by @TaraBannow I referenced above. The suggestion that women in the biopharmaceutical industry who are nursing "need to stay home" needs to change: https://www.statnews.com/2024/01/11/jpm24-pumping-space-women-health-care-biotech/ https://www.statnews.com/2024/01/11/jpm24-pumping-space-women-health-care-biotech/"
[X Link](https://x.com/PearlF/status/1845586990814867567) 2024-10-13T22:06Z [----] followers, [----] engagements
""STAT6 is a historically undrugged essential transcription factor in the IL-4/IL-13 signaling pathways & the central driver of T helper type [--] (TH2) inflammation in allergic diseases.KT-621 is an investigational first-in-class once daily oral STAT6 degrader with dupilumab-like activity in preclinical models & the potential to address multiple allergic & atopic diseases including atopic dermatitis asthma and chronic obstructive pulmonary disease among others." Proud of the team @KymeraTx for this monumental milestone This is a great day for our industry: first in human for a STAT6 directed"
[X Link](https://x.com/PearlF/status/1849425311542210908) 2024-10-24T12:18Z [----] followers, [---] engagements
Limited data mode. Full metrics available with subscription: lunarcrush.com/pricing
@PearlF Pearl Freier
Pearl Freier posts on X about insurance, rfk, $abbv, ceo the most. They currently have [-------] followers and [----] posts still getting attention that total [-----] engagements in the last [--] hours.
Engagements: [-----] #
- [--] Week [------] +188%
- [--] Month [-------] +58%
- [--] Months [-------] +86%
- [--] Year [---------] -28%
Mentions: [--] #
- [--] Week [--] +27%
- [--] Month [---] +50%
- [--] Months [---] +64%
- [--] Year [---] -15%
Followers: [-------] #
- [--] Week [-----] +0.42%
- [--] Month [-----] +1.40%
- [--] Months [-----] +4.90%
- [--] Year [-----] +13%
CreatorRank: [-------] #
Social Influence
Social category influence stocks finance countries technology brands vc firms cryptocurrencies us election travel destinations social networks celebrities
Social topic influence insurance, rfk #515, $abbv, ceo, $pfe, acquisition, in the, investment, novartis, link #2613
Top accounts mentioned or mentioned by @statnews @endpts @fiercebiotech @ldtimmerman @matthewherper @devahaz @thebiotechclub @bijans @mikeisaac @mcuban @mroliverbarnes @daphnezohar @openai @andrewedunn @chrissyfarr @ddiamond @bradloncar @maxonwifi @samdavisesq @grok
Top assets mentioned AbbVie Inc (ABBV) Pfizer, Inc. (PFE) Novartis AG (NVS) Novo-Nordisk (NVO) Eli Lilly and Company (LLY) Johnson & Johnson (JNJ) Biogen Inc (BIIB) Bristol-Myers Squibb Co (BMY) CVS Health Corp (CVS) Regeneron Pharmaceuticals Inc (REGN) GSK plc (GSK) Sanofi (SNY) AstraZeneca PLC (AZN) Moderna Inc (MRNA) Basilisk (BSX) Vertex Protocol (VRTX) Merck & Co., Inc. (MRK) Microsoft Corp. (MSFT) Intellia Therapeutics, Inc (NTLA) Boston Scientific Corporation (BSX)
Top Social Posts
Top posts by engagements in the last [--] hours
"@tarahaelle @zeynep @apoorva_nyc It would have been [--] thing to tell the public not 2use n95 & medical grade masks because those are critical supplies [--] healthcare workers but anyone telling the public that masks in general (incl cloth masks) weren't needed or helpful was misleading people even if unintentional"
X Link 2020-08-15T15:54Z [----] followers, [--] engagements
"@tarahaelle @zeynep @apoorva_nyc Can you send the link please"
X Link 2020-08-15T21:04Z [----] followers, [--] engagements
"Merck/MSD's Otto Ritter announced the release of DyVE (Dynamics of Value Evolution) an open source Julia framework for computational value dynamics supporting complex decision makingparticularly in R&D and business he said. https://www.linkedin.com/feed/update/urn:li:activity:6995778196172337153/ http://GitHub.com/Merck https://www.linkedin.com/feed/update/urn:li:activity:6995778196172337153/ http://GitHub.com/Merck"
X Link 2022-11-08T19:25Z [----] followers, [--] engagements
"Cambridge MA-based biotech Codiak BioSciences filed for Chapter [--] & is up for sale. Founded in [----]. Story by @ky_lahucik https://endpts.com/codiak-files-for-chapter-11-bankruptcy-as-most-executives-head-for-the-exit/ https://endpts.com/codiak-files-for-chapter-11-bankruptcy-as-most-executives-head-for-the-exit/"
X Link 2023-03-27T15:38Z [----] followers, [----] engagements
"Investment firm General Atlantic filed for IPO. Some of the life sciences companies they've invested in incl CinCor PathAI Immunocore Karuna Royalty Pharma Ginkgo WuXi Biologics Akero Centessa Acelyrin Hutchmed Ultima Genomics Third Harmonic https://www.reuters.com/markets/deals/general-atlantic-confidentially-files-us-ipo-bloomberg-news-2023-12-11/ https://www.reuters.com/markets/deals/general-atlantic-confidentially-files-us-ipo-bloomberg-news-2023-12-11/"
X Link 2023-12-11T19:49Z [----] followers, [---] engagements
"@bcmerchant I don't know if it's a new era when I think most of the people you listed above were on his business advisory council in [----] which seemed to fall apart less than a year later. It's also unfair to compare Cook & Pichai with Musk's relationship with Trump"
X Link 2024-11-06T22:09Z [----] followers, [--] engagements
"Gilead is also one of Xilio Therapeutics collaborators & paid $43.5M upfront as part of deal announced in March [----] "for the rights to develop and commercialize the biotech's tumor-activated IL-12 candidate. $GILD $XLO"
X Link 2025-02-12T22:48Z [----] followers, [----] engagements
"Here's the Boston Business Journal story about Foghorn Therapeutics moving to Watertown $FHTX https://www.bizjournals.com/boston/news/2025/07/02/foghorn-cambridge-watertown-lease.htmlutm_source=st&utm_medium=en&utm_campaign=ae&utm_content=BO&j=40531126&senddate=2025-07-02&utm_term=ep1&empos=p1 https://www.bizjournals.com/boston/news/2025/07/02/foghorn-cambridge-watertown-lease.htmlutm_source=st&utm_medium=en&utm_campaign=ae&utm_content=BO&j=40531126&senddate=2025-07-02&utm_term=ep1&empos=p1"
X Link 2025-07-02T19:54Z [----] followers, [---] engagements
"Pfizer's EVP/CDO also described some of AI's impact on drug discovery incl identification of drug targets for cancer 50% faster than other methods she said $PFE: "our proprietary OncoScout cancer target identification engine helped us identify two actionable targets in breast & prostate cancer that are in experimental validation achieving this at least 50% faster than traditional methods." https://twitter.com/i/web/status/2011893730597359726 https://twitter.com/i/web/status/2011893730597359726"
X Link 2026-01-15T20:10Z [----] followers, [----] engagements
"Pfizer & N*vavax enter into a licensing agreement & pays $30M upfront w/milestones up to $500M. Pfizer will be able to use the Matrix-M adjuvant technology for up to [--] disease areas with its products. Link to the press release is in the reply"
X Link 2026-01-20T15:54Z [----] followers, [---] engagements
"Here's a link to the ARPA-H story in @FierceBiotech https://www.fiercebiotech.com/research/arpa-h-director-eyes-future-beyond-vaccines-and-winning-biotech-race-against-china https://www.fiercebiotech.com/research/arpa-h-director-eyes-future-beyond-vaccines-and-winning-biotech-race-against-china"
X Link 2026-01-20T16:38Z [----] followers, [----] engagements
""When do we get the 1st AI-developed drug" CNBC's @SaraEisen asked Pfizer CEO Albert Bourla. Bourla responded: "I think you will not see an AI-solely developed drug. But you will see a drug that is better & comes to the market faster because of the AI." $PFE A link to the CNBC video/interview is in the reply https://twitter.com/i/web/status/2013690916666519553 https://twitter.com/i/web/status/2013690916666519553"
X Link 2026-01-20T19:11Z [----] followers, [----] engagements
"Pfizer CEO on AI in his post below: "There were many conversations about AI's impact but I think we are often asking the wrong question. The question is not how we do the same with less. It is how we do much much more with more.""
X Link 2026-01-23T15:50Z [----] followers, [----] engagements
"Discussions are underway to boycott the World Cup when its in the US this year. This would be similar to when countries boycotted the Olympics when it was in Moscow in 1980: German soccer federation official wants World Cup boycott considered because of Trump https://t.co/GWisxWJSry German soccer federation official wants World Cup boycott considered because of Trump https://t.co/GWisxWJSry"
X Link 2026-01-24T03:27Z [----] followers, [----] engagements
"Siqi Chen's 6-year old daughter Mira was diagnosed w/ a rare brain tumor adamatinomatous craniopharyngioma in '24. Last night @blader shared an app/MRI viewer he built to track tumor progression & shared how others could use it too. Mira's been responding well to an experimental treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibits VEGF proteins). See Siqi's post: over the weekend i built an app that i sincerely hope you will never have a need for but if you do happen to need a friendly free private mri viewer"
X Link 2026-01-26T15:48Z [----] followers, [---] engagements
"Some advice for US from Novartis/Gal on being more competitive w/China on clinical trials: "Form a recognition system for hospitals which excel in trial leadership using objective measures (e.g. number of trials patients recruited etc) $NVS"
X Link 2026-01-26T18:06Z [----] followers, [----] engagements
"@lulumeservey @MikeIsaac Is it considered a slur to refer to someone like Margaret Hoover as a conservative-leaning author/commentator/podcaster"
X Link 2026-01-28T01:49Z [----] followers, [---] engagements
"And FP had a small/niche audience anyway it's not as if they were getting Alex Cooper or Joe Rogan numbers. It looks like Ellison hired BW hoping to pick up more of Fox News' audience Her 1st big interview was someone that mostly appeals to the Fox audience & the ratings were low. And the whole Twitter Files thing was it mostly a niche group that was interested in that https://twitter.com/i/web/status/2016937935132598524 https://twitter.com/i/web/status/2016937935132598524"
X Link 2026-01-29T18:14Z [----] followers, [--] engagements
"Aetna Wun Trombley left NGM Biopharmaceuticals in March to become CEO of targeted protein degradation company co-founded by @CarolynBertozzi & Versant Ventures' Clare Ozawa Lycia Therapeutics. $50M round. @BiotechFischer is Board director. LYTACS platform https://bit.ly/2BUTJT0 https://bit.ly/2BUTJT0"
X Link 2020-06-10T22:41Z [----] followers, [--] engagements
"GE Ventures alum @OliverKeownMD is Director & co-founder of Sunnyvale CA-based @IntuitiveSurg corporate venture capital arm Intuitive Ventures & announced $100M fund. Digital health precision diagnostics platform technologies & medtech. Congrats https://bit.ly/35CuU9v https://bit.ly/35CuU9v"
X Link 2020-10-27T14:40Z [----] followers, [--] engagements
"Risa Stack joined RA Capital as Venture Partner [--] expand West Coast presence & supporting newco formation/incubation. She was a partner at KPCB & co-founded Veracyte. Then GE Ventures' General Mgr of New Business Creation & involved w/ Evidation Health Vineti & more. Congrats"
X Link 2020-11-30T21:05Z [----] followers, [--] engagements
"NY-based Stablix Therapeutics launched last wk w/ $63M led by founding investor Versant Ventures w/participation from NEA Cormorant Euclidean &Alexandria. Research inspired by work in Henry Colecraft's lab/Columbia. Versant's @carlo_rizzuto is acting CEO https://bit.ly/3iBmjMA https://bit.ly/3iBmjMA"
X Link 2021-06-12T00:06Z [----] followers, [--] engagements
"Digital health/health analytics company Apervita has ceased operations as of 10/1 after having raised a total of $59.5M in VC financing from investors over the years including Optum Ventures GE Ventures Baird Capital & Pritzker.(Crunchase data) https://www.healthcareitnews.com/news/apervita-ceases-operations https://www.healthcareitnews.com/news/apervita-ceases-operations"
X Link 2021-10-07T19:14Z [----] followers, [--] engagements
"Pfizer was [--] of [--] bidders in bankruptcy court for Covid-flu at-home test developer Lucira Health with $21.2M & runner up Pearsanta filed an objection on Tuesday to the planned sale of the Emeryville CA company to Pfizer: Story by @rleuty_biotech https://www.bizjournals.com/sanfrancisco/news/2023/04/11/flu-covid-pfizer-lucira-pfe-pearsanta-aditxt-adtx.html https://www.bizjournals.com/sanfrancisco/news/2023/04/11/flu-covid-pfizer-lucira-pfe-pearsanta-aditxt-adtx.html"
X Link 2023-04-11T20:11Z [----] followers, [---] engagements
"Boulder CO-based clinical stage oncology company @OnKureTx announced $54M Series C round. Their pipeline includes a collaboration with Pfizer on Phase [--] trial with their oral Class [--] HDAC inhibitor for the treatment of NRAS melanoma & their lead discovery program is OKI-219 a selective PI3K alpha H1047R inhibitor. https://www.globenewswire.com/news-release/2023/05/23/2674144/0/en/OnKure-Therapeutics-Announces-54-Million-Series-C-Financing.html https://twitter.com/i/web/status/1661395834716540930"
X Link 2023-05-24T15:36Z [----] followers, [---] engagements
"Japanese pharma Astellas will license & develop new gene therapy from San Diego-based biotech startup co-founded by Boston Children's Hospital researcher Alan Beggs for a devastating rare muscle disorder (X-linked myotubular myopathy). Comments from @MCRPM https://www.statnews.com/2023/06/08/xlmtm-gene-therapy-astellas-pharma/ https://www.statnews.com/2023/06/08/xlmtm-gene-therapy-astellas-pharma/"
X Link 2023-06-08T11:50Z [----] followers, [----] engagements
"San Diego-based gene therapy Kate Therapeutics also announced $51M Series A co-led by Versant Ventures & Los Angeles-based VC Westlake Village BioPartners with participation from Osage University Partners & UF Innovate. CEO is @kforrestdna Congrats to all involved https://www.prnewswire.com/news-releases/kate-therapeutics-debuts-with-51-million-series-a-to-develop-next-generation-genetic-medicines-to-treat-muscle-and-heart-diseases-301844583.html"
X Link 2023-06-08T12:00Z [----] followers, [---] engagements
"Sharon Kedar co-founder & partner at Northpond Ventures @npv_vc posted on Linked In after the acquisition of one of their portfolio companies by Lilly for $2.4B was announced. On $DICE Therapeutics she said [--] yrs ago when they invested in the B round it https://www.linkedin.com/feed/update/urn:li:activity:7076964678630789121/updateEntityUrn=urn%3Ali%3Afs_feedUpdate%3A%28V2%2Curn%3Ali%3Aactivity%3A7076964678630789121%29 https://www.linkedin.com/feed/update/urn:li:activity:7076964678630789121/updateEntityUrn=urn%3Ali%3Afs_feedUpdate%3A%28V2%2Curn%3Ali%3Aactivity%3A7076964678630789121%29"
X Link 2023-06-21T18:46Z [----] followers, [----] engagements
"Biogen to acquire Plano Texas-based Reata Pharmaceuticals in cash deal w/enterprise value of $7.3B. Largest M&A transaction in BIIB's history eclipsing '03 merger with Idec ($6.8B) https://investors.biogen.com/news-releases/news-release-details/biogen-acquire-reata-pharmaceuticals https://investors.biogen.com/news-releases/news-release-details/biogen-acquire-reata-pharmaceuticals"
X Link 2023-07-28T11:40Z [----] followers, 12.1K engagements
"Ex Kleiner Perkins & ex GE Ventures partner Risa Stack ex Mohr Davidow & GE Ventures partner Rowan Chapman & ex B Capital's @Widya__Mulya started a new life sciences/tech VC firm story by @rleuty_biotech Congrats https://www.bizjournals.com/sanfrancisco/news/2023/12/21/bevc-uc-berkeley-biotech-startups.html https://www.bizjournals.com/sanfrancisco/news/2023/12/21/bevc-uc-berkeley-biotech-startups.html"
X Link 2023-12-22T00:46Z [----] followers, [----] engagements
""Platform companies may therefore have to be constructed differently with more tightly controlled spending. Leaner Rizzuto said with smaller staffs more outsourced functions and smaller physical footprints." Versant Ventures Managing Director @carlo_rizzuto #JPM24 New from #JPM24: A look at how #biotech #startups may be built in the aftermath of the sector's pullback. Newly optimistic biotech investors weigh lessons of sectors downturn https://t.co/wRcOJUwBwx New from #JPM24: A look at how #biotech #startups may be built in the aftermath of the sector's pullback. Newly optimistic biotech"
X Link 2024-01-11T20:40Z [----] followers, [---] engagements
""Christos Kyratsous Ph.D. co-head of Regeneron Genetic Medicines says the DB-OTO program was conceived in a brainstorming session between Regeneron & Decibel Therapeutics about six years ago where they considered what diseases they could make an impact in." #ASGCT2024 $REGN Two congenitally deaf children due to mutations of the otoferlin gene can now hear for the first time after being treated with Regeneron's investigational AAV gene therapy DB-OTO in CHORD clinical trial according to data presented at #ASGCT2024. https://t.co/s61j7aZnDJ $REGN https://t.co/NEFCipEzuU Two congenitally deaf"
X Link 2024-05-08T17:12Z [----] followers, [----] engagements
"Novartis's Chief Strategy & Growth Officer Ronny Gal wrote a post re: their collab w/ Versant Ventures to form a new Vancouver Canada-based biotech Biorealis Biosciences. Focused on developing next-generation xRNA-based medicines for kidney disease https://www.linkedin.com/posts/ronny-gal-a5b769_novartis-employs-creative-deal-structure-activity-7232360966888263681-AYCsutm_source=share&utm_medium=member_desktop https://www.linkedin.com/posts/ronny-gal-a5b769_novartis-employs-creative-deal-structure-activity-7232360966888263681-AYCsutm_source=share&utm_medium=member_desktop"
X Link 2024-08-22T14:11Z [----] followers, [----] engagements
"NYC-based @formationbio recruited @DavidASteinberg to be their CBO. Prior to Formation DS was a GP at Longwood Fund for [--] yrs (after [--] yrs at PureTech) & was founding CEO of Pyxis Oncology Rectify Be Biopharma & more. Formation Bio is seeking to in-license non-oncology Phase II & III assets focusing on small molecules & biologic molecules (Abs peptides bispecifics oligos etc.). Formation's collaborators incl Sanofi & Open AI & they recently raised $372M Series D. Their investors incl Sanofi A16Z Thrive Capital Sequoia Emerson Collective & more. Congrats"
X Link 2024-10-29T22:27Z [----] followers, [---] engagements
"WuXi AppTec plans to sell the US & UK-based operations of their cell & gene therapy business to NY-based PE firm Altaris. Altaris acquired digital health company Sharecare in $518M deal in Oct. Story below: #WuXiAppTec which is among five Chinese #CDMOs targeted by the #BIOSECUREact is selling the U.S. and U.K.-based operations of #WuXiAdvancedTherapies its #cellandgenetherapy unit to New York-headquartered investment firm Altaris. https://t.co/TW7Ib13Eb6 #pharmamanufacturing #WuXiAppTec which is among five Chinese #CDMOs targeted by the #BIOSECUREact is selling the U.S. and U.K.-based"
X Link 2024-12-26T12:47Z [----] followers, [----] engagements
"AbbVie announced a new oncology R&D collab w/ Waltham MA-based clinical stage immunooncology Xilio Therapeutics. T-cell engagers. $52M upfront (incl $10M equity) & potential up to $2.1B. CEO is @OtherReneRusso $ABBV $XLO https://www.fiercebiotech.com/biotech/abbvie-pays-xilio-52m-upfront-latest-t-cell-engager-deal https://www.fiercebiotech.com/biotech/abbvie-pays-xilio-52m-upfront-latest-t-cell-engager-deal"
X Link 2025-02-12T22:47Z [----] followers, [----] engagements
"Piece by @JacobPlieth said that Xilio Therapeutics only had "just a few months' cash in the bank" until the AbbVie deal w/$52M upfront was announced today. "Importantly it buys the biotech some more time during which it might be able to generate more data and perhaps seek fresh cash from investors." 1/n https://twitter.com/i/web/status/1889810952381415533 https://twitter.com/i/web/status/1889810952381415533"
X Link 2025-02-12T22:56Z [----] followers, [----] engagements
"More about Xilio Therapeutics' deals and pipeline in @JacobPlieth piece below: $XLO #immunoonc https://www.oncologypipeline.com/apexonco/xilios-second-bailout https://www.oncologypipeline.com/apexonco/xilios-second-bailout"
X Link 2025-02-12T23:02Z [----] followers, [---] engagements
"Moderna's former longtime Chief Digital & Operational Officer Marcello Damiani ('15-'23) is joining John Oyler's senior leadership team as BeiGene's/BeOne Medicines Chief Technology Officer. Congrats $ONC & Marcello Welcome Marcello Damiani Marcello's expertise and vision will be a key part of our journey as we drive digital innovation to new heights. We look forward to the impact he will make as part of our growing team. Welcome Marcello Damiani Marcello's expertise and vision will be a key part of our journey as we drive digital innovation to new heights. We look forward to the impact he"
X Link 2025-05-05T16:35Z [----] followers, [----] engagements
"Another biotech leaving Cambridge for Watertown MA: [--] of Eli Lilly's collaborators Foghorn Therapeutics terminated its Cambridge/Tech Square lease [--] yrs early to lease [-----] sq ft at [--] Coolidge Ave in Watertown (another Alexandria building). Story by @hannah_reports $FHTX"
X Link 2025-07-02T19:48Z [----] followers, [----] engagements
"Japanese medical device company Terumo plans to acquire University of Oxford spinout OrganOx for 1.5B. OrganOx specializes in advanced organ preservation devices for Normothermic Machine Perfusion (NMP) & can preserve organs longer by "circulating oxygen and nutrient rich perfusate through the organ at near-body temperature" 1/n https://twitter.com/i/web/status/1960017551074656517 https://twitter.com/i/web/status/1960017551074656517"
X Link 2025-08-25T16:32Z [----] followers, [---] engagements
"Praxis Precision Medicines will discuss the epilepsy drug clinical trial results at the American Epilepsy Society Annual Meeting on Saturday @AmEpilepsySoc #AES2025"
X Link 2025-12-05T20:06Z [----] followers, [---] engagements
"Novo Nordisk has a car driving around Union Square advertising the new pill version of Wegovy according to @statnews @elaineywchen #JPM26 #JPM2026. $NVO"
X Link 2026-01-12T22:43Z [----] followers, [----] engagements
"Amgen & direct-to-patient healthcare company @ro announced a research collaboration to study insurance coverage of GLP-1 drugs #JPM26 #JPM2026. Ro's CEO & co-founder is @ZReitano. Millions of patients have used Ro to check their insurance & goals from the joint collab with Amgen will incl spotlighting where gaps in coverage for patients exist & how to expand access to treatment as the next generation of GLP-1s come to market. A link to the press release is in the reply. https://twitter.com/i/web/status/2011225728428171687 https://twitter.com/i/web/status/2011225728428171687"
X Link 2026-01-13T23:55Z [----] followers, [----] engagements
"Amgen's VP Center for Observational Research Brian Bradbury on the research & RWD collab w/@ro on GLP-1s #JPM26 #JPM2026 $AMGN: "Through this collaboration we aim to leverage Ros robust real-world data across the care ecosystem to better understand the patient experience & identify where limitations & unmet needs persist. Together we can translate those insights into future therapy development innovations in care delivery & greater patient outcomes." https://twitter.com/i/web/status/2011228297179299978 https://twitter.com/i/web/status/2011228297179299978"
X Link 2026-01-14T00:06Z [----] followers, [----] engagements
"Regeneron's co-founder & CSO on AI: "You @matthewherper mentioned that we created REGN-Cov that saved Trumps life. That was in the clinic in [--] or [--] months from initiating the project to going into a human being; AI cant compete with that." #JPM26 #JPM2026 Regeneron's chief scientist George Yancopoulos has some thoughts about the use of AI in medicine. https://t.co/DyxwvW06hw Regeneron's chief scientist George Yancopoulos has some thoughts about the use of AI in medicine. https://t.co/DyxwvW06hw"
X Link 2026-01-15T12:32Z [----] followers, [----] engagements
"Here's a link to the Boston Scientific/Penumbra story by @MedTechDive @EliseReuter $BSX #PEN #JPM26 #JPM2026 https://www.medtechdive.com/news/boston-scientific-acquire-penumbra/809734/ https://www.medtechdive.com/news/boston-scientific-acquire-penumbra/809734/"
X Link 2026-01-15T18:56Z [----] followers, [---] engagements
"1 of the reasons the #JPM26 conference will probably always be in SF is because Bay Area is #1 in AI medtech & VC & is always in the Top [--] for biotech. And CA has Nvidia Google Apple Amgen Genentech/Roche Gilead Illumina & BioMarin to name a few Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis https://t.co/Rv9tIvlYyZ Boston Scientific $BSX plans to acquire Alameda CA-based"
X Link 2026-01-15T19:23Z [----] followers, [----] engagements
"Misleading info by Bowden on vaccines. Many doctors' offices across the US were getting paid $40 for Covid vaccine shots in [----] for patients covered by United Health. Most people don't go to the hospital setting to get vaccinated & I don't know what Houston Methodist charges for hospitalized patients https://twitter.com/i/web/status/2012721912934248895 https://twitter.com/i/web/status/2012721912934248895"
X Link 2026-01-18T03:01Z [----] followers, [---] engagements
"Reportedly the largest autonomous lab in the world is in South Boston at @ginkgo. Can also work with their internal team remotely on "autonomous labs as a service" or cloud lab & CRO. They're down the street from Vertex. See below: What lab experiments would you like to run remotely on our autonomous lab How will you unlock biology if you can focus on hypotheses & data and leave the wet work to us Reach out to me if youd like to brainstorm What lab experiments would you like to run remotely on our autonomous lab How will you unlock biology if you can focus on hypotheses & data and"
X Link 2026-01-23T20:05Z [----] followers, [----] engagements
"If your startup announces a $1B + financing as its first round suggestions below are to refer to it as a coconut round or as an avocado round or something else instead of referring to it as a seed round. I can't relate personally but here's the article below: When a startup is born fully capitalized and worth billions seed no longer fits. Call it a coconut or avocado roundthe language hasnt caught up. Some data some thoughts some @beffjezos https://t.co/QQTRGIZKqU When a startup is born fully capitalized and worth billions seed no longer fits. Call it a coconut or avocado roundthe language"
X Link 2026-01-26T13:15Z [----] followers, [----] engagements
"Here's a link to Novartis $NVS senior exec Ronny Gal's Linked In post today w/ his suggestions for how the US system for clinical trials could get better & be more competitive with China: https://www.linkedin.com/pulse/early-clinical-trials-go-so-goes-innovation-us-risk-ronny-gal-ivtse/trackingId=N%2BViuFvljeSW7KhXPTjSYw%3D%3D https://www.linkedin.com/pulse/early-clinical-trials-go-so-goes-innovation-us-risk-ronny-gal-ivtse/trackingId=N%2BViuFvljeSW7KhXPTjSYw%3D%3D"
X Link 2026-01-26T17:57Z [----] followers, [----] engagements
"if the "zombie cell clearing cream" is a Weleda product it may be available at Erewhon or even Whole Foods :) Longevity going mainstream is mostly quite good for loyal But it is also.quite cringe at times zombie cell clearing cream https://t.co/2xXxWrer2h Longevity going mainstream is mostly quite good for loyal But it is also.quite cringe at times zombie cell clearing cream https://t.co/2xXxWrer2h"
X Link 2026-01-28T01:07Z [----] followers, [----] engagements
"AstraZeneca & Pfizer alum now Biorelate CSO made some suggestions for providing frameworks for making AI in drug discovery more of a measurable asset incl the use of well established value quantification methods like PTRS but without the R. "Traditionally applied to later-stage clinical assets we can reuse the concept (as straight PTS no R) to offer a structured approach in earlier phases of drug discovery. This would provide a quantifiable framework for target evaluation and crucially enable tracking of AI contributions. Expressed as a percentage (0100%) PTS as envisioned here would"
X Link 2026-01-31T00:54Z [----] followers, [---] engagements
"Here's a link to the op-ed in Biopharma Boardroom: https://www.biopharmaboardroom.com/opinion/1/4280/is-ai-pharmas-fools-gold-why-evidence-driven-metrics-will-define-real-roi.html https://www.biopharmaboardroom.com/opinion/1/4280/is-ai-pharmas-fools-gold-why-evidence-driven-metrics-will-define-real-roi.html"
X Link 2026-01-31T00:56Z [----] followers, [---] engagements
"@dbinthed @ramez The poll below suggests to me there is a messaging problem of some kind. I was speculating on what it might be even though it's surprising to me that the approval rating isn't much lower for thuggish tactics law-breaking & murder https://x.com/Noahpinion/status/2018730290991304994s=20 Yet another poll in which Americans trust REPUBLICANS more on immigration than Democrats. Even after the ICE murders. https://t.co/LW1wKBZdeJ https://x.com/Noahpinion/status/2018730290991304994s=20 Yet another poll in which Americans trust REPUBLICANS more on immigration than Democrats. Even"
X Link 2026-02-04T02:20Z [----] followers, [--] engagements
"@cremieuxrecueil How come it doesn't have to go through clinical trials & is there evidence that the pill is safe & that it works for weight loss Does the pill have side effects Why does Novo have to get FDA approval but Hims doesn't"
X Link 2026-02-05T16:30Z [----] followers, [----] engagements
"One more thing on Hims' new GLP-1 pill story below by @ZacharyBrennan confirms that the FDA holds Novo $NVO & Lilly $LLY to a higher standard than $HIMS. "Hims & Hers said all of its compounded active pharmaceutical ingredients 'are sourced exclusively from FDA-registered facilities' but pharmaceutical-grade pills are required to adhere to a higher level of safety assurances than compounded drugs." Our stull story: https://t.co/uTuduVRqKi Our stull story: https://t.co/uTuduVRqKi"
X Link 2026-02-05T17:11Z [----] followers, [----] engagements
"@NY_LBSS @cremieuxrecueil No Ro isn't selling the same pill that Hims announced today. Here's a link to Ro's announcement last month. They're selling Novo Nordisk's Wegovy pill in partnership with the drug's manufacturer & creatorNovo. https://ro.co/weight-loss/oral-wegovy/ https://ro.co/weight-loss/oral-wegovy/"
X Link 2026-02-05T17:41Z [----] followers, [--] engagements
"Novartis has a provocative [--] second ad airing during Super Bowl this weekend. It's an awareness ad for prostate cancer screening/blood testing. Gronk is in it & prostate cancer survivor Coach Arians. h/t @damiangarde @statnews. Link to story & video is in the reply $NVS #pcsm"
X Link 2026-02-06T00:04Z [----] followers, [--] engagements
"Here's a link to the @statnews story about commercials airing during the Super Bowl this weekend including pharmas Novartis Boehringer & Novo telehealth Ro & online pharmacy/compounder Hims https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/ https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/"
X Link 2026-02-06T00:08Z [----] followers, [--] engagements
"Here's the YouTube video & Novartis' Super Bowl ad $NVS https://www.youtube.com/watchv=lMTcZb48aVU https://www.youtube.com/watchv=lMTcZb48aVU"
X Link 2026-02-06T00:16Z [----] followers, [--] engagements
"Below is what Adweek said about Novartis's Super Bowl ad for '26"Novartis Gets Cheeky." $NVS It's a prostate cancer awareness ad to promote early detection & blood testing (which also supports brand awareness for the company.) Novartis is the maker of prostate cancer drug Pluvicto a targeted adioligand therapy (RLT) for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). A link to Adweek's story is in the reply: https://twitter.com/i/web/status/2019567712087797910 https://twitter.com/i/web/status/2019567712087797910"
X Link 2026-02-06T00:23Z [----] followers, [---] engagements
"Here's the Adweek story about the Novartis commercial planned to air during the Super Bowl: $NVS https://www.adweek.com/convergent-tv/novartis-super-bowl-ad-tight-ends/ https://www.adweek.com/convergent-tv/novartis-super-bowl-ad-tight-ends/"
X Link 2026-02-06T00:25Z [----] followers, [---] engagements
"Novartis has a provocative [--] second ad airing during Super Bowl this weekend. It's an awareness ad for prostate cancer screening/blood testing. Gronk & several football players are in it w/ prostate cancer survivor Coach Arians. h/t @damiangarde @statnews $NVS #pcsm Link to story & video is in the reply https://twitter.com/i/web/status/2019572476619964657 https://twitter.com/i/web/status/2019572476619964657"
X Link 2026-02-06T00:42Z [----] followers, [---] engagements
"Here's a link to the @statnews story about commercials airing during the Super Bowl this weekend including pharmas Novartis Boehringer & Novo telehealth Ro & online pharmacy/compounder Hims https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/ https://www.statnews.com/2026/02/05/drug-ads-super-bowl-sunday-fda/"
X Link 2026-02-06T00:44Z [----] followers, [---] engagements
"Mark Cuban said that IVF drugs are cheaper through TrumpRx or that's how I interpreted his comment below. I don't know which drugs he's talking about but for some patients TrumpRx might be a win"
X Link 2026-02-06T20:53Z [----] followers, [---] engagements
"The NIH had been moving forward w/ research for a vaccine against Epstein-Barr (EBV is linked to lymphoma MS & lupus) but federal vaccine initiatives are being stopped by HHS. A call for Congress below to intervene by directing $ to specific lines of vaccine researchw/ clear objectives enforceable milestones & mandatory reporting from HHS to ensure compliance: https://twitter.com/i/web/status/2019914604646707502 https://twitter.com/i/web/status/2019914604646707502"
X Link 2026-02-06T23:22Z [----] followers, [---] engagements
""The largest study to date of leucovorins effectiveness for treating autism traits has been retracted because of data inconsistencies and statistical issues according to a notice posted last week by the European Journal of Pediatrics." Largest leucovorin-autism trial retracted https://t.co/qSa1GKgs3K Largest leucovorin-autism trial retracted https://t.co/qSa1GKgs3K"
X Link 2026-02-07T19:08Z [----] followers, [---] engagements
""The retraction of this paper removes a significant portion of the already weak evidence supporting the value of folinic acid as a treatment for autism Thomas Challman a pediatrician at Geisinger College of Health Sciences who specializes in neurodevelopmental conditions wrote in an email to The Transmitter. Until we have acceptable evidence of safety and effectiveness folinic acid use as a treatment for autism is not appropriate outside of a well-designed clinical trial. https://twitter.com/i/web/status/2020213369056137273 https://twitter.com/i/web/status/2020213369056137273"
X Link 2026-02-07T19:09Z [----] followers, [---] engagements
"An updated FDA org chart from @biospace: nearly 90% of senior leaders who were at the FDA a year ago are no longer there. Most FDA employees are usually "career staff" who worked for multiple FDA commissioners & years of training to be knowledgeable incl cell & gene therapies. Pazdur had worked for the Bush Obama Trump [--] & Biden administrations. He wasn't a Biden appointee"
X Link 2025-12-03T21:33Z [----] followers, 111.7K engagements
"One of the world's most famous anti-vaxxers RFK Jr. is the HHS Secretary. His political appointee at the FDA unilaterally overruled FDA employees & vaccine experts & refused to review a vaccine that the EU Australia & Canada agreed to review. Here's an unlocked link to the WSJ story by @l_e_whyte https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=qiCiTx&reflink=desktopwebshare_permalink https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=qiCiTx&reflink=desktopwebshare_permalink"
X Link 2026-02-13T04:24Z [----] followers, [----] engagements
"Biogen announced a new collaboration w/ Israeli biotech NeuroSense Therapeutics to assess their Phase [--] ALS candidate PrimeC's impact on neurofilaments for which elevated levels are considered an ALS biomarker. Biogen will receive blood samples from [--] trial patients which will be used for a biomarker analysis study https://www.fiercebiotech.com/biotech/lookout-next-als-biomarker-success-biogen-pens-pact-israeli-biotech https://www.fiercebiotech.com/biotech/lookout-next-als-biomarker-success-biogen-pens-pact-israeli-biotech"
X Link 2023-06-14T16:24Z [----] followers, [----] engagements
"More below on Eli Lilly's acquisition of San Francisco-based biotech DICE Therapeutics for $2.4B in cash incl potential psoriasis drug & great to see win for DICE's CEO too who was prev Achaogen CEO. Story by @matthewherper $DICE $LLY https://www.statnews.com/2023/06/20/eli-lilly-to-acquire-dice-therapeutics-in-2-4-billion-deal/utm_campaign=twitter_organic&utm_source=twitter&utm_medium=social https://www.statnews.com/2023/06/20/eli-lilly-to-acquire-dice-therapeutics-in-2-4-billion-deal/utm_campaign=twitter_organic&utm_source=twitter&utm_medium=social"
X Link 2023-06-20T12:09Z [----] followers, [----] engagements
"Wow FTC is intervening in a small biotech collab w/ a French pharma that could potentially help patients living w/ Pompe disease. Biotech companies need collabs w/large cos & the $ to develop new drugs: https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html"
X Link 2023-12-11T22:07Z [----] followers, 88.3K engagements
"Genentech built on the experience when designing the CHIMES study for multiple sclerosis. Inozyme Pharma's COO commented: "African-American Hispanic patients with MS come to see their doctor & their doctors are actually able to show data in their population Winton said. The majority of the time thats the drug that theyre going to say I want to be on. https://twitter.com/i/web/status/1790451221590946286 https://twitter.com/i/web/status/1790451221590946286"
X Link 2024-05-14T18:36Z [----] followers, [----] engagements
"@CFLabsResearch @ChrisHeery @bradloncar @BioLabsNC Norbert Bischofberger's company Kronos Bio works with Chordoms Foundation Labs in Durham"
X Link 2024-05-20T03:08Z [----] followers, [--] engagements
"Mountain View CA-based biotech IGM Biosciences is the latest biotech to pivot from cancer to autoimmune disease. Their CEO CSO & Chief Medical Officer are also departing the company. Story by @JamesPharma $IGMS https://www.fiercebiotech.com/biotech/igm-completes-pivot-cancer-autoimmune-shaking-c-suite-and-hinting-layoffs https://www.fiercebiotech.com/biotech/igm-completes-pivot-cancer-autoimmune-shaking-c-suite-and-hinting-layoffs"
X Link 2024-10-01T19:41Z [----] followers, [---] engagements
"Physician scientist & cancer genomics expert Howard Y. Chang discovered a new class of genes termed long noncoding RNAs can control gene activity throughout the genome. He co-founded Boundless Bio Accent Tx Orbital Tx & Cartography Bio. He starts at $AMGN on 12/16 as CSO & SVP of Research. Chang succeeds Ray Deshaies the former senior vice president of Research whose departure was announced earlier this year. Chang will report to Jay BradnerAmgen's EVP of R&D https://twitter.com/i/web/status/1859371921525428614 https://twitter.com/i/web/status/1859371921525428614"
X Link 2024-11-20T23:03Z [----] followers, [----] engagements
"A Vida Ventures spokesperson told @endpts the firm is "preparing to raise a fourth fund." Fund [--] $825M was announced in mid [----] the story said. The remaining co-founder on the leadership team is Arie Belldegrun. Helen Kim & Rajul Jain are still listed as sr managing dir & managing director respectively [--] of Vida Ventures [--] co-founding managing dirs @arjun__goyal & Stefan Vitorovic left the firm h/t @ky_lahucik @maxonwifi. Biotech VC firm launched [--] yrs ago & $1.8B AUM. No word yet if theyre launching their own fund or joining another VC firm.https://t.co/Csy22cL7Df [--] of Vida Ventures 3"
X Link 2024-12-10T22:51Z [----] followers, [----] engagements
"Vida Ventures' portfolio includes Allogene AskBio Capstan Therapeutics Tectonic Therapeutic Centessa Dyne Kronos Bio Kyverna Neogene Peloton Therapeutics Scorpion Therapeutics ReCode Therapeutics Volastra Vigil Neuro"
X Link 2024-12-10T22:55Z [----] followers, [---] engagements
"This was the 1st sizable M&A deal of the #JPM25 news cycle2 days ago Michigan-based medtech company Stryker announced plans to buy Irvine CA-based Inari Medical in $4.9B deal. More below: #JPM2025"
X Link 2025-01-09T00:14Z [----] followers, [---] engagements
"On Vera Therapeutics's fusion protein (atacicept) for IgA nephropathy Derek wrote "the Phase II for that one looked very impressive and the next readout is from a Phase 3." $VERA Derek Lowe wrote a post on @NatureMedicine 's [--] Clinical Trials That Will Shape Medicine in '25. He said he's very interested in Arvinas/ $ARVN's Phase [--] data on their estrogen receptor degrader vepdegestrant (ARV-471) "a key test for targeted protein degradation" he said Derek Lowe wrote a post on @NatureMedicine 's [--] Clinical Trials That Will Shape Medicine in '25. He said he's very interested in Arvinas/ $ARVN's"
X Link 2025-01-24T18:43Z [----] followers, [----] engagements
"The US is projected to have [--] fewer new FDA-approved drugs annually & 18% fewer drugs entering clinical trials if the WH"s proposed NIH cuts are approved by Congress said Venrock VC @bobkocher & @USCSchaeffer professor @DanaPGoldman in op-ed. cc'ing @BRobertsVC"
X Link 2025-05-02T00:30Z [----] followers, [----] engagements
"M&A seemed to be a rare event at Regeneron until [----] when they acquired immunooncology biotech Checkmate Pharmaceuticals. More below: 2seventy Decibel now 23andMe Regeneron loves an opportunistic M&A move for some previous high-fliers in biotech: https://t.co/418FTv6c19 2seventy Decibel now 23andMe Regeneron loves an opportunistic M&A move for some previous high-fliers in biotech: https://t.co/418FTv6c19"
X Link 2025-05-19T12:08Z [----] followers, [---] engagements
"Alnylam Pharmaceuticals also raised around $26M in [----] in "Less-Than-Spectacular IPO" (from Genomeweb's headline in 6/04) I was curious how much Alnylam raised to get off the ground. It's unbelievable. $17M in combined series A and B funding back in '02. Kinda puts today's megarounds in perspective.you don't always need it if you build right. Of course costs have soared since then but still. I was curious how much Alnylam raised to get off the ground. It's unbelievable. $17M in combined series A and B funding back in '02. Kinda puts today's megarounds in perspective.you don't always need it"
X Link 2025-07-31T15:57Z [----] followers, [---] engagements
"Boston-based biotech Praxis $PRAX w/good news--announced an early end to its Embold clinical trial studying their epilepsy drug relutrigine in patients w/ genetic mutations SCN2A & SCN8A developmental and epileptic encephalopathies because the trial's data monitoring committee said "it was clear relutrigines efficacy had been demonstrated." A link to the @FierceBiotech story is in the reply"
X Link 2025-12-05T19:57Z [----] followers, [----] engagements
"Here's a link to the @fiercebiotech story about Praxis Precision Medicines $PRAX https://www.fiercebiotech.com/biotech/praxis-claims-efficacy-success-phase-2-seizure-trial-setting-approval-talks-fda https://www.fiercebiotech.com/biotech/praxis-claims-efficacy-success-phase-2-seizure-trial-setting-approval-talks-fda"
X Link 2025-12-05T19:59Z [----] followers, [----] engagements
"Biogen's ALS gene therapy received accelerated FDA approval in '23 for rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph [--] trial published in 12/22 @JAMANeuro said that drug not only delays disease progression also helps patients regain lost function $BIIB"
X Link 2025-12-29T17:16Z [----] followers, [----] engagements
""Stopping disease progression & making improvements over [--] to [--] years is unheard of in this type of ALS said 1st author Tim @MillerLabNeuro @WashUNeurology Professor & co-director of the WashU Medicine ALS Center. $BIIB Tofersen shows benefits compared with what we expect to see for these participants with about 25% of participants experiencing improvement. These results provide hope that we can change the trajectory of this devastating disease and we are optimistic we can do the same for other forms of ALS. https://twitter.com/i/web/status/2005690397633200617"
X Link 2025-12-29T17:20Z [----] followers, [---] engagements
""new data on the long-term use of tofersen suggest that over about [--] years of treatment roughly 1/4 of participants in [--] study group experienced stabilization of symptoms & even functional improvement in grip strength & respiratory function." $BIIB #ALS"
X Link 2025-12-29T17:22Z [----] followers, [----] engagements
"Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis"
X Link 2026-01-15T18:53Z [----] followers, [----] engagements
"In case anyone was concerned about JP Morgan investment bankers this week Boston Scientific came through on the last day of the conference with $14.5B acquisition of Penumbra. #JPM26 $BSX $PEN Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion #JPM26 #JPM2026 $PEN founded in '04 makes heart devices to remove clots from blood vessels treating conditions incl pulmonary embolism stroke & deep vein thrombosis https://t.co/Rv9tIvlYyZ Boston Scientific $BSX plans to acquire Alameda CA-based cardiovascular medtech Penumbra for $14.5 Billion"
X Link 2026-01-15T19:02Z [----] followers, [---] engagements
"Novartis Chief Strategy Officer Ronny Gal wrote that the US is at "risk of losing its edge" in early clinical trials to China. He explains some of China's advantages incl: "Chinese hospitals have stronger incentives to participate in trials. They are ranked & evaluated on participation in trials notably early trials." A link to his Linked In post is in the reply: https://twitter.com/i/web/status/2015845639804891605 https://twitter.com/i/web/status/2015845639804891605"
X Link 2026-01-26T17:53Z [----] followers, 46.3K engagements
"Novartis/Gal on advantages China has w/ their hospitals re: clinical trials: "They deliver well on commitments to patient recruiting & are motivated to be fairly compensated for their participation in trials to build their long-term reputation & scientific leadership. They also dont seek to maximize profits from trials as this is viewed as a potentially unhealthy practice." https://twitter.com/i/web/status/2015847218713133402 https://twitter.com/i/web/status/2015847218713133402"
X Link 2026-01-26T18:00Z [----] followers, [----] engagements
"they said they're going to issue nearly [-----] additional H-2B guest worker visas through September but are they going to have ICE lurking in the driveways or at bus stations & parking lots to send the workers to detention centers to meet detention/deportation numbers "The Trump administration has said it will issue nearly [-----] additional H-2B guest worker visas through September effectively doubling the maximum number that can be issued in a year." https://t.co/HEOzmPWFxJ "The Trump administration has said it will issue nearly [-----] additional H-2B guest worker visas through September"
X Link 2026-02-01T01:27Z [----] followers, [---] engagements
"From a few months ago after an ICE raid at a Hyundai plant in Georgia which grabbed [---] Asians who were in the US legally: "South Korean President Lee Jae Myung called for improvements in the U.S. visa system as he spoke about the Sept. [--] immigration raid that resulted in the arrest of more than [---] South Korean workers at at Hyundai's sprawling auto plant west of Savannah. https://www.pbs.org/newshour/nation/south-korean-workers-who-were-detained-in-a-hyundai-factory-raid-are-now-headed-home-heres-what-else-to-know"
X Link 2026-02-01T01:36Z [----] followers, [---] engagements
"Here's the YouTube video & Novartis' [----] Super Bowl ad for prostate cancer screening/blood testing $NVS $NVS https://www.youtube.com/watchv=lMTcZb48aVU https://www.youtube.com/watchv=lMTcZb48aVU"
X Link 2026-02-06T00:45Z [----] followers, [----] engagements
"@dr_coops Gronk is in it :)"
X Link 2026-02-09T02:47Z [----] followers, [---] engagements
""Trial designs will prioritize early mechanistic evidence of the drugs degrading their intended protein in patients & confirm the right ligase/target pairing alongside artificial intelligence-guided degrader design and patient stratification" said $BMY's EVP & Chief Medical Officer https://twitter.com/i/web/status/2020869945924481264 https://twitter.com/i/web/status/2020869945924481264"
X Link 2026-02-09T14:38Z [----] followers, [----] engagements
"@CJMacDonald @step @Beast @MrBeast Congratulations"
X Link 2026-02-09T22:19Z [----] followers, [---] engagements
"@SamDavisEsq @A_May_MD Their Chief Legal Officer is ex Jones Day & their Chief Policy Officer is an attorney who worked for the DOJ and worked at the FDA for over [--] yrs. Maybe they assumed the current FDA would do nothing or would just send another letter like last year"
X Link 2026-02-09T22:38Z [----] followers, [---] engagements
"@SamDavisEsq @A_May_MD They backed down really quickly on the oral pill though & maybe they were caught off guard by FDA's swift negative response & referral to DOJ within [--] hrs or so of Hims' announcement"
X Link 2026-02-09T23:59Z [----] followers, [--] engagements
"Has the FDA commented the retraction notice [--] the leucovorin & autism study was published on Jan [--]. $GSK had stopped manufacturing it in '97 (for toxic side effects of chemotherapy.) HHS & FDA announced in Sept that leucovorin was receiving a label update for autism: "This action establishes the first FDA-recognized therapeutic for children with cerebral folate deficiency & autistic symptoms." The largest trial on leucovorin was just retracted. Now there's basically no causal signal leucovorin works in the published literature. The likelihood this will help with autism is falling."
X Link 2026-02-10T21:41Z [----] followers, [----] engagements
"I started to read about Hawley/Warren bill to see if has potential solutions for reducing healthcare & drug spend in US & saw they told CBS News today that it's "Big Pharma" who "continue to gobble up every independent healthcare provider & pharmacy they can find." cc @mcuban"
X Link 2026-02-10T23:06Z [----] followers, [----] engagements
"Moderna's seasonal investigational influenza vaccine mRNA-1010 has been submitted & accepted for review in the EU Canada & Australia $MRNA. Kennedy's FDA in the US officially refused to review the vaccine & "the U.S. Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) has notified the Company that it will not initiate a review of the biologics license application (BLA) for its investigational influenza vaccine mRNA-1010 and has issued a Refusal-to-File (RTF) letter. Moderna had exercised a Priority Review Voucher to facilitate a timely review of the"
X Link 2026-02-10T23:33Z [----] followers, [----] engagements
"Moderna said as recently as August in a meeting before it submitted its application [--] approval of the vaccine "the FDA suggested that it would review the filing & assess issues with the comparator during that process." The EU Canada & Australia have all accepted $MRNA's application: The FDA has refused to accept an application from Moderna to review its first mRNA seasonal flu vaccine the company said. https://t.co/mBu4Up1Lh5 The FDA has refused to accept an application from Moderna to review its first mRNA seasonal flu vaccine the company said. https://t.co/mBu4Up1Lh5"
X Link 2026-02-11T00:36Z [----] followers, [----] engagements
"Interesting update re: national governors' meeting:"
X Link 2026-02-11T02:36Z [----] followers, [---] engagements
"Fox News wrote a story: https://www.foxnews.com/politics/national-governors-association-reportedly-cancels-meeting-trump-after-white-house-snubs-democrats https://www.foxnews.com/politics/national-governors-association-reportedly-cancels-meeting-trump-after-white-house-snubs-democrats"
X Link 2026-02-11T02:40Z [----] followers, [--] engagements
"The U.S. Attorney is "Judge Jeanine" from Fox News. Her ex husband Albert received a pardon from the president"
X Link 2026-02-11T03:35Z [----] followers, [---] engagements
"From Time Magazine's list of Time [---] Health honorees:"
X Link 2026-02-12T05:04Z [----] followers, [--] engagements
"One more screenshot from Time Magazine's list of Time [---] Health honorees in 2026:"
X Link 2026-02-12T05:08Z [----] followers, [--] engagements
"Johnson & Johnson announced last week that [-----] multiple myeloma/blood cancer patients globally have been treated with a $JNJ CAR-T cell therapy. J&J and Legend Biotech $LEGN received FDA approval for Carvykti in [----]. Link to J&J's writeup is in the reply: #mmsm #immunoonc"
X Link 2026-01-20T16:17Z [----] followers, [---] engagements
"Merck & BMS alum and ex Checkmate Pharmaceuticals (acquired by Regeneron) Chief Medical Officer Dave Mauro joins clinical stage "TechBio" company @RecursionPharma as CMO. He starts 6/1. $RXRX Congrats 1/n https://ir.recursion.com/news-releases/news-release-details/recursion-appoints-david-mauro-md-phd-chief-medical-officer https://ir.recursion.com/news-releases/news-release-details/recursion-appoints-david-mauro-md-phd-chief-medical-officer"
X Link 2023-05-16T15:26Z [----] followers, [----] engagements
"Clinical Trial Result Of The Year went to Karuna Therapeutics (now a Bristol Myers Squibb company) for "its pivotal Phase III trial of KarXT (xanomeline-trospium) in schizophrenia which showed impressive efficacy and differentiation from standard-of-care generic antipsychotics. KarXT is expected to be a first-in-class M1/M4-preferring muscarinic receptor agonist designed to preferentially stimulate muscarinic receptors in the central nervous system. Analysts deemed its efficacy comparable to prior antipsychotics but with a differentiated side effect profile. The judging panel also took note"
X Link 2024-05-09T14:36Z [----] followers, [---] engagements
"FDA issued a notice yesterday that said do not use Cue Health's Covid-19 diagnostic tests for home & OTC use & not in patient care settings"due to increased risk of false test results." https://www.fda.gov/medical-devices/safety-communications/do-not-use-cue-healths-covid-19-tests-due-risk-false-results-fda-safety-communication https://www.fda.gov/medical-devices/safety-communications/do-not-use-cue-healths-covid-19-tests-due-risk-false-results-fda-safety-communication"
X Link 2024-05-14T16:29Z [----] followers, [----] engagements
"Im at #CNSSummit2024 conf in Boston/Everett & the speakers are Bristol Myers Squibb EVP/Chief Medical Officer Samir Hirawat & former Karuna Therapeutics senior execs Steve Paul & Stephen Brennan talking w/ @CNSSummit chairman @akalali"
X Link 2024-11-12T14:28Z [----] followers, [---] engagements
"Bristol Myers Squibb announced a collaboration w/Microsoft to advance AI-driven early detection of lung cancer using FDA-cleared radiology AI algorithms via $MSFT's Precision Imaging Network. Using lung cancer-specific AI workflows they said. Press release is in the reply"
X Link 2026-01-20T15:39Z [----] followers, [----] engagements
"45% of major biopharma companies' data sciences leaders surveyed by BCG said they've seen "demonstrated proof-of- value" using generative AI for molecule design. 50% said they've started to use it routinely. (Surveyed incl AZ GILD PFE NVS MRK LLY SNY ABBV Roche Bayer). 5% had said it was in early pilots for them. The paper said "molecule design can involve a range of GenAI algorithms including generative adversarial networks recurrent neural networks variational autoencoders flow-based models & others." [--] data sciences leaders co-authored a paper to discuss how generative AI is reshaping"
X Link 2026-02-08T23:57Z [----] followers, [----] engagements
"Adaptive clinical trial designs will have broader adoption across the industry in '26 said Daiichi Sankyo's global head of R&D Ken Takeshita. Lundbeck's EVP of R&D Johan Luthman said: "Advances in adaptive trial designs will mark the beginning of the end for rigid clinical trial phases blurring the boundaries between Phases I-IV. Instead of sequential steps integrated continuous development models will emerge with proactive real-time analytics converging dynamically with integration of safety efficacy post-marketing insights & real-world evidence." From Scrip's R&D predictions for '26 issue"
X Link 2026-02-09T14:00Z [----] followers, [----] engagements
"Bristol Myers Squibb's EVP/CMO & Head of Development Cristian Massacesi said targeted protein degradation is poised to become the default therapeutic strategy for undruggable targets in '26. "Building on pioneering IMiD work advanced next-generation approaches such as CELMoD agents ligand-directed degraders& degrader antibody conjugates continue to transform outcomes in blood cancers & beyond as they are systematically integrated into discovery & development pipelines." https://twitter.com/i/web/status/2020869141767372965 https://twitter.com/i/web/status/2020869141767372965"
X Link 2026-02-09T14:35Z [----] followers, [----] engagements
""Recent pivotal trials & expansion into targets like BCL6 & GSPT1 indicate a tipping point that will reshape asset selection & regulatory dialogue across biopharma" said Bristol Myers Squibb's EVP & Chief Development Officer Cristian Massacesi $BMY"
X Link 2026-02-09T14:45Z [----] followers, [----] engagements
"Moderna's president Stephen Hoge said Blackstone $BX had invested $750M in the development of Modernas $MRNA flu vaccine including a 40700-person clinical trial. CNN story today: as recently as August FDA's meeting gave no indication they would refuse their application for review. EU Canada & Australia accepted the submitted application & are reviewing it: NEW: The F.D.A. refused to accept an application from Moderna for its mRNA flu vaccine. Its reason: The agency did not think Moderna compared the new vaccine to one of the best flu shots available. The company spent $750M+ on a [-----] person"
X Link 2026-02-11T00:51Z [----] followers, [----] engagements
"SF-based Maplight Therapeutics received $8.1M from @MichaelJFoxOrg 2undertake "investigation of brain circuits & mechanisms that are responsible for triggering psychiatric symptoms in Parkinsons disease" & potential therapeutic strategies incl depression https://www.prnewswire.com/news-releases/maplight-therapeutics-receives-8-1-million-for-parkinsons-disease-research-301180711.html https://www.prnewswire.com/news-releases/maplight-therapeutics-receives-8-1-million-for-parkinsons-disease-research-301180711.html"
X Link 2020-11-30T17:23Z [----] followers, [--] engagements
"Sanofi has now called off the deal w/Maze Therapeutics as a result of the FTC's injunction: What happens to the potential clinical trial for Pompe disease patients now https://www.globenewswire.com/news-release/2023/12/11/2794272/0/en/Press-Release-Statement-on-FTC-challenge-to-proposed-license-agreement-with-Maze-Therapeutics.html Wow FTC is intervening in a small biotech collab w/ a French pharma that could potentially help patients living w/ Pompe disease. Biotech companies need collabs w/large cos & the $ to develop new drugs: https://t.co/ASCRcKtxU7"
X Link 2023-12-11T22:11Z [----] followers, [----] engagements
"I missed the @FierceBiotech @JamesPharma story earlier today about @ClimbBio & their deal for the preclinical IgA antibody. It's not only large companies who are doing cash upfront deals & below is the link to the story 1/n"
X Link 2025-01-09T22:07Z [----] followers, [----] engagements
"Here's the link to Fierce Biotech story I reference above: https://www.fiercebiotech.com/biotech/climb-bio-ascends-eliem-legacy-9m-upfront-deal-preclinical-iga-antibody https://www.fiercebiotech.com/biotech/climb-bio-ascends-eliem-legacy-9m-upfront-deal-preclinical-iga-antibody"
X Link 2025-01-09T22:11Z [----] followers, [---] engagements
"More US clinical trials infrastructure advice from Novartis/Gal $NVS: "Establish guidelines on appropriate costs of trial participation" & "Adopt & adapt best business practices streamlining contract templates and implementing efficient regional review mechanisms for multi-center trials." https://twitter.com/i/web/status/2015849540763410541 https://twitter.com/i/web/status/2015849540763410541"
X Link 2026-01-26T18:09Z [----] followers, [----] engagements
"More on FDA from story below: "In November Prasad sent an email alleging that [--] childrens deaths were linked to Covid vaccines but he has yet to publicly produce data to back up the claim. The email also said that staff who disagreed with his operating principles should submit their resignations." New from me: The Moderna decision is part of a pattern of regulatory U-turns and overruling of FDA staff by Prasad a Covid-vaccine critic 🎁🔗https://t.co/BwzK5Fnvt5 New from me: The Moderna decision is part of a pattern of regulatory U-turns and overruling of FDA staff by Prasad a Covid-vaccine"
X Link 2026-02-12T02:57Z [----] followers, 10.3K engagements
"It's also not true that RFK is "pivoting away from vaccines" especially since just this week a political appointee at FDA who works for him overruled FDA career reviewers to prevent a seasonal flu vaccine from being reviewed that EU Canada & Australia accepted for review. Heres an unlocked to WSJ story last nigh. The political appointee sent a letter to Moderna that the FDA refused to review the vaccine: https://www.wsj.com/health/healthcare/why-the-fda-blocked-modernas-new-flu-shot-84fdaab6st=So4baV&reflink=desktopwebshare_permalink"
X Link 2026-02-12T16:04Z [----] followers, [---] engagements
"@jordixiol Did they hire a salesforce & spend money and time preparing for launch a year earlier than they needed to because of feedback they were given during the FDAs new voucher review process"
X Link 2026-02-13T22:38Z [----] followers, [---] engagements
"@grok @TAT001122TAT @jakescottMD Was Moderna's flu vaccine application to FDA incomplete"
X Link 2026-02-14T11:37Z [----] followers, [--] engagements
"@grok @TAT001122TAT @jakescottMD Hi Grok thanks for the responses to this question. An associate professor of law @david__simon sent the below information from Cornell Law School's website on [--] U.S. Code 706: https://www.law.cornell.edu/uscode/text/5/706 https://www.law.cornell.edu/uscode/text/5/706"
X Link 2026-02-14T14:55Z [----] followers, [--] engagements
"An update below on clinical stage biotech Maze Therapeutics @MazeInBiotech who reported positive first-in-human data [--] months ago from Phase [--] clinical trial evaluating MZE829 as a potential treatment for APOL1 kidney disease (AKD). Based in South San Francisco: Meet the company angling to be the Bay Area's first biotech IPO of [----] https://t.co/JkurssNoP6 via @SFBusinessTimes Meet the company angling to be the Bay Area's first biotech IPO of [----] https://t.co/JkurssNoP6 via @SFBusinessTimes"
X Link 2025-01-07T23:19Z [----] followers, [---] engagements
"Not just new medicines. FDA will likely also prevent updated flu vaccines for the fall in the UStaking away the choice to get a flu vaccine in the US in September. If you don't want to get a flu shot don't get one but don't prevent others who want one from getting the shot. The complete stunner here is at no point in any of this did anybody say that it was not adequate. An unacceptable level of uncertainty for innovators to bring new medicines to patients. https://t.co/8n3Sxn9ufk The complete stunner here is at no point in any of this did anybody say that it was not adequate. An unacceptable"
X Link 2026-02-11T01:49Z [----] followers, [----] engagements
"About Rick Pazdur: the founding director of the FDA's Oncology Center of Excellence explained to @l_e_whyte WSJ why he resigned from FDA in December h/t filmmaker @WhitStillman. An unlocked link to the interview is in the reply: $XBI $IBB #immunooncology"
X Link 2026-02-14T03:11Z [----] followers, [----] engagements
"Here's an unlocked link to Rick Pazdur's interview w/ WSJ's published tonight @l_e_whyte: #oncology #immunooncology https://www.wsj.com/health/healthcare/top-fda-scientist-explains-why-he-quit-after-getting-a-promotion-from-rfk-jr-2c85a510st=neKRLd&reflink=desktopwebshare_permalink https://www.wsj.com/health/healthcare/top-fda-scientist-explains-why-he-quit-after-getting-a-promotion-from-rfk-jr-2c85a510st=neKRLd&reflink=desktopwebshare_permalink"
X Link 2026-02-14T03:19Z [----] followers, [---] engagements
"One of HHS Secretary Kennedy's spokespeople commented: to WSJ: "Dr. Makarywith his clinical experience in treating cancer patientsleads the agency with a profound sense of urgency in delivering cures to the American people.""
X Link 2026-02-14T03:40Z [----] followers, [---] engagements
"Gr8 to read abt another Tillman Gerngross/Polaris innovative co in NH Kevin Isett is CEO/co-founder. OrbiMed in too https://x.com/BentheFidler/status/629275944822382592 Ex-Adimab Execs Startup Avitide Gets $7.6M For Drug Purifying Tech http://t.co/7nwULV9SE2 #startups #biotech https://x.com/BentheFidler/status/629275944822382592 Ex-Adimab Execs Startup Avitide Gets $7.6M For Drug Purifying Tech http://t.co/7nwULV9SE2 #startups #biotech"
X Link 2015-08-06T13:08Z [----] followers, [--] engagements
"@angelicalavito I think the Nashville airport has a clinic too I think I remember seeing one. Sounds like a good idea"
X Link 2018-10-08T14:18Z [----] followers, [--] engagements
"Provocative post by @MassBio on the drug pricing debate & where is high % $ going The Fortune [--] list includes health insurers United Anthem Aetna; PBMs CVS Health & Express Scripts; drug distributors McKesson AmerisourceBergen & Cardinal Health. http://bit.ly/2Bx264c http://bit.ly/2Bx264c"
X Link 2019-02-13T13:39Z [----] followers, [--] engagements
"The Bristol Myers Squibb-Pfizer Alliance is partnering with @fitbit "to develop 'educational content and guidance' that will help device owners recognize if they are at risk of atrial fibrillation as well as to seek appropriate support and diagnosis of the condition." 1/3 $PFE"
X Link 2019-10-17T19:15Z [----] followers, [--] engagements
"Article said the specifics of the program are still under development but here's what the partners revealed: "It will rely on the atrial fibrillation detection feature that Fitbit is still developing for their wearables. Once this algorithm has been fully tested submitted to 2/3"
X Link 2019-10-17T19:15Z [----] followers, [--] engagements
"@vishalgulati_ @OmicsOmicsBlog @LifeSciVC It sounds like an important metric to evaluate because timelines and failure rates on average haven't improved over [--] to [--] yrs. Some exceptions include Agios and Vertex. Pharma companies have been working with some form of AI for [--] years"
X Link 2019-12-17T18:32Z [----] followers, [--] engagements
"New KRAS-focused drug licensing deal: Verastem Oncology pays $3M upfront to Tokyo-based Chugai Pharma for worldwide development & sales rights to RAF/MEK inhibitor CH5126766 (CKI27) which is in tests for KRAS mutant solid tumors $VSTM #oncology http://bit.ly/2QBas2q http://bit.ly/2QBas2q"
X Link 2020-01-09T19:28Z [----] followers, [--] engagements
"Darren Carroll left Eli Lilly in Aug & he was SVP & VP Business Development ('10-'19) & VP New Ventures ('05-'10) incl head Lilly Ventures ($200M VC fund) & Lilly Asian Ventures. [--] yrs at Lilly. He has now joined @PolarisVC in Boston as partner. Congrats https://bwnews.pr/37VxjeO https://bwnews.pr/37VxjeO"
X Link 2020-01-10T12:09Z [----] followers, [--] engagements
"Last month I mentioned that @polarisvc announced they recruited former Kleiner Perkins partner & former Atara Biotherapeutics CEO Isaac Ciechanover as a partner in their San Francisco office. https://bwnews.pr/2PmUW8B https://bwnews.pr/2PmUW8B"
X Link 2020-01-10T12:15Z [----] followers, [--] engagements
"@ldtimmerman Hi Luke- consider doing the next Tweetchat w/@millennium_US CEO Deborah Dunsire. I know she's on Facebook"
X Link 2011-10-05T16:12Z [----] followers, [--] engagements
"@ldtimmerman @masterlongevity Did he discuss GVs investment in EQRx on the panel #JPM20"
X Link 2020-01-14T23:11Z [----] followers, [--] engagements
"@WyomingScience I don't know if she supports open borders that admin deported a lot of ppl. I saw that she made a negative comment elsewhere about Bernie doing press with Marianne Williamson today because MW is an anti-vaxxer & he might be supporting anti-vaxxers now too (if he didn't before)"
X Link 2020-02-24T21:42Z [----] followers, [--] engagements
"@ldtimmerman @OtelloVC What's also scary is that most of the rural areas probably don't have much intensive care capacity & staffing. Patient zero in NJ (not rural area) shared his harrowing story of doctors not knowing how to treat him & he almost died at age [--]. He's Chinese & had contacts advise him"
X Link 2020-03-31T22:57Z [----] followers, [--] engagements
"@daviesbj @ldtimmerman https://www.businessinsider.com/trump-doctor-health-letter-who-wrote-it-2018-5 https://www.businessinsider.com/trump-doctor-health-letter-who-wrote-it-2018-5"
X Link 2020-04-10T21:45Z [----] followers, [--] engagements
"Bay Area-based rare disease drug developer Ultragenyx received their 2nd FDA drug approval in [--] weeks. New approved drug is Dojolvi for the treatment of a rare set of genetic metabolic disorders which can occur in newborns. $RARE https://bit.ly/2AipOn8 https://bit.ly/2AipOn8"
X Link 2020-07-01T14:37Z [----] followers, [--] engagements
"@zakkohane Have you seen this news about Tesla and CureVac https://endpts.com/tesla-chief-elon-musk-teams-up-with-covid-19-player-curevac-to-build-rna-microfactories/ https://endpts.com/tesla-chief-elon-musk-teams-up-with-covid-19-player-curevac-to-build-rna-microfactories/"
X Link 2020-07-02T13:22Z [----] followers, [--] engagements
"Genome editing expert TJ Cradick @NucleaseLab has joined Excision BioTherapeutics as Chief Scientific Officer. He was previously Head of Genome Editing at CRISPR Therapeutics for close to [--] yrs. Congrats https://bit.ly/31lmr8r https://bit.ly/31lmr8r"
X Link 2020-08-05T11:56Z [----] followers, [--] engagements
"@ldtimmerman @skathire Why aren't they being held accountable for plan that could have been implemented in April & "went poof into thin air" because they didn't want to help NY NJ WA CA & states considered "blue states." https://www.vanityfair.com/news/2020/07/how-jared-kushners-secret-testing-plan-went-poof-into-thin-air https://www.vanityfair.com/news/2020/07/how-jared-kushners-secret-testing-plan-went-poof-into-thin-air"
X Link 2020-08-13T19:47Z [----] followers, [--] engagements
"MIT biology professor and pioneering researcher of cancer cell metabolism Matthew Vander Heiden @mvh_lab has been named the next director of MITs Koch Institute for Integrative Cancer Research @kochinstitute effective April [--]. Congrats https://news.mit.edu/2021/matthew-vander-heiden-koch-institute-0331 https://news.mit.edu/2021/matthew-vander-heiden-koch-institute-0331"
X Link 2021-03-31T17:43Z [----] followers, [--] engagements
""While serving as director Vander Heiden plans to continue working as a medical oncologist at the Dana-Farber Cancer Institute where he treats prostate cancer patients." https://www.bostonglobe.com/2021/03/31/business/matthew-vander-heiden-named-new-director-mits-koch-institute-integrative-cancer-research/ https://www.bostonglobe.com/2021/03/31/business/matthew-vander-heiden-named-new-director-mits-koch-institute-integrative-cancer-research/"
X Link 2021-03-31T17:50Z [----] followers, [--] engagements
"@sububoston @srikosuri @aaronmring I don't know where that information is from but see the below thread: https://x.com/DrSidMukherjee/status/1389243618360188931 I got a thousand replies to my questions but not any that I needed/wanted. [--]. I know the lab data. do we have HUMAN data on AZ/Covaxin vaccine effectiveness against B1618 etc in India [--]. And why aren't any of these studies in PEER REVIEWED JOURNALS https://x.com/DrSidMukherjee/status/1389243618360188931 I got a thousand replies to my questions but not any that I needed/wanted. [--]. I know the lab data. do we have HUMAN data on"
X Link 2021-05-06T02:54Z [----] followers, [--] engagements
"VC @UcianeScarlett left Oxford Sciences Innovation & joined @MPMCapital as Principal last month. Congrats"
X Link 2021-10-19T12:34Z [----] followers, [--] engagements
"Emanuele Ostuni has left Novartis Oncology to join a stealth early stage biotech focused on radioligand therapeutics as CEO + 1st full-time employee. He was prev NVS Oncology head of cell & gene therapy for Europe for [--] yrs Sandoz prior. He co-founded Enumeral Biomedical in '09"
X Link 2022-02-01T20:25Z [----] followers, [--] engagements
"Novartis announced license option agreement w/ gene therapy company Voyager Therapeutics for [--] capsids to use in potential gene therapies for neurological diseases w/option to access capsids for [--] other targets. VYGR's next-gen AAV platform called https://www.novartis.com/news/media-releases/novartis-voyager-therapeutics-reach-license-option-agreement-next-generation-gene-therapy-vectors-neurological-diseases https://www.novartis.com/news/media-releases/novartis-voyager-therapeutics-reach-license-option-agreement-next-generation-gene-therapy-vectors-neurological-diseases"
X Link 2022-03-08T17:05Z [----] followers, [--] engagements
"More on Novartis & Voyager Therapeutics deal. Glenn Pierce is VYGR's interim CSO & Michael Higgins is interim CEO https://endpts.com/novartis-takes-a-gamble-on-voyagers-new-aav-tech-inks-1-5b-gene-therapy-discovery-pact/ https://endpts.com/novartis-takes-a-gamble-on-voyagers-new-aav-tech-inks-1-5b-gene-therapy-discovery-pact/"
X Link 2022-03-08T17:08Z [----] followers, [--] engagements
"Venrock & @BRobertsVC led $20M B round in next-gen PBM startup SmithRx. SF-based Founder & CEO is Anthem & Collective Health alum Jake Frenz. CVS/Caremark Cigna/ES & United are "Big Three" w/80% of market & "control drug prices." Story by @erinbrodwin https://www.axios.com/venrock-seriesb-smithrx-20-million-fbe764bd-ce04-478d-8af4-80154d375c19.html https://www.axios.com/venrock-seriesb-smithrx-20-million-fbe764bd-ce04-478d-8af4-80154d375c19.html"
X Link 2022-03-10T18:46Z [----] followers, [--] engagements
"It might be early but I think it's exciting 2c a biotech VC firm Venrock invest in a next-generation PBM & potentially be part of a solution [--] disrupt status quo of Caremark Cigna & United using combined 80% market share to manipulate drug prices increase OOP & harm patients"
X Link 2022-03-10T19:03Z [----] followers, [--] engagements
"@pandemona @goldman They're also the same firm that said they hadn't hired female VC partners because they couldn't find women that met their "standards." Moritz interview with @emilychangtv in '15: https://www.youtube.com/watchv=1i-RXdi15Bg https://www.youtube.com/watchv=1i-RXdi15Bg"
X Link 2022-11-20T18:34Z [----] followers, [--] engagements
"FDA approved the 1st echinocandin drug in a decade--@CidaraThera & @MelintaTx announced that antifungal Rezzayo received approval under priority review for candidemia & invasive candidiasis in adults. Cidara's CEO is @jefflstein. Melinta's CEO is Christine Miller. Congrats Cidara is also conducting a Phase III trial w/Rezzayo for the prevention of invasive fungal diseases in adults undergoing allogeneic blood & marrow transplantation. Story by @KatherineMLewin https://endpts.com/fda-approves-cidaras-rezzayo-as-antifungal-treatment-for-candidemia-and-invasive-candidiasis/"
X Link 2023-03-23T11:54Z [----] followers, [----] engagements
"Here's the press release w/FDA approval news for $CDTX & $MLNT and antifungal drug Rezzayo: https://www.businesswire.com/news/home/20230322005767/en/Cidara-Therapeutics-and-Melinta-Therapeutics-Announce-FDA-Approval-of-REZZAYO%E2%84%A2-rezafungin-for-injection-for-the-Treatment-of-Candidemia-and-Invasive-Candidiasis https://www.businesswire.com/news/home/20230322005767/en/Cidara-Therapeutics-and-Melinta-Therapeutics-Announce-FDA-Approval-of-REZZAYO%E2%84%A2-rezafungin-for-injection-for-the-Treatment-of-Candidemia-and-Invasive-Candidiasis"
X Link 2023-03-23T11:57Z [----] followers, [---] engagements
"RIP to the archive of articles on the life sciences healthcare & technology industries across major hub cities in the US that used to be covered by media company Xconomy. Informa acquired Xconomy & it looks like the archives & links to stories are no longer easily findable online"
X Link 2023-03-23T13:11Z [----] followers, [----] engagements
"Sanofi & Regeneron's Dupixent could also be the 1st biologic medicine to treat COPD/chronic obstructive pulmonary disease. Phase [--] data published in NEJM yesterday. 1st advance in COPD in close to [--] yrs Sanofi CEO said. Story by @AndrewE_Dunn w/ contributed reporting from @ArmstrongDrew https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/ https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/ https://endpts.com/touting-dupixent-win-in-copd-sanofi-execs-pitch-leading-immunologys-next-era/"
X Link 2023-05-22T17:43Z [----] followers, [----] engagements
"Sanofi and Regeneron are also co-developing itepekimab an IL-33 antibody with a readout planned in [----] testing the drug in combination with Dupixent for COPD patients. More on this & the immunology pipeline in the above story"
X Link 2023-05-22T17:45Z [----] followers, [---] engagements
"@AppleHelix And the personal relationship they have to say the least"
X Link 2023-06-13T20:49Z [----] followers, [----] engagements
"@AppleHelix It turns out even the companies she co-founded have a connection to her father since they are Polaris Partners portfolio companies according to the Stat story. Her dad has a long history with Polaris. Polaris is also known to hire new VCs who are related to other VCs at the firm"
X Link 2023-06-13T21:25Z [----] followers, [----] engagements
"Other significant Texas biotech acquisitions/exits incl Dallas-founded AveXis acquired by Novartis in $8.7B deal in '18 Dallas-based Peloton Therapeutics (not the bike) acquired by Merck in '19 for $1.05B in cash & additional $1.15B if milestones met Houston-based Tanox acquired by Genentech in '06 for $919M Fort Worth-based Encore Vision bought by Novartis/Alcon for $375M in cash & additional $90M if milestones met Biogen to acquire Plano Texas-based Reata Pharmaceuticals in cash deal w/enterprise value of $7.3B. Largest M&A transaction in BIIB's history eclipsing '03 merger with Idec"
X Link 2023-07-28T13:13Z [----] followers, 10K engagements
"Supreme Court temporarily blocked a nationwide settlement with OxyContin maker Purdue Pharma to emerge from bankruptcy as a different entity that would shield members of the Sackler family who own the company from civil lawsuits over the toll of opioids. https://apnews.com/article/supreme-court-opioid-crisis-purdue-bankruptcy-bd417e036d9f6db4b2916fdfbdb56252 https://apnews.com/article/supreme-court-opioid-crisis-purdue-bankruptcy-bd417e036d9f6db4b2916fdfbdb56252"
X Link 2023-08-10T22:26Z [----] followers, [---] engagements
"News below on 1st-ever in vivo CRISPR-based gene editing therapy cleared by FDA to enter Phase [--] trials. One step closer to being the 1st single-dose treatment for rare & fatal genetic disease ATTR amyloidosis. Intellia Tx founded in [----] & NTLA-2001 trial collab with Regeneron We did it FDA IND clearance of NTLA-2001 Im so proud of our team. Congrats to all A big thank you to our clinical trial participants and sites as well as our investigators who are contributing to the advancement of our therapies. The future looks bright #OneIntellia We did it FDA IND clearance of NTLA-2001 Im so proud"
X Link 2023-10-18T18:26Z [----] followers, [---] engagements
"In just [--] yrs base editing has moved from concept to [--] Phase I clinical studies incl BEAM-101 & [---] (@BeamTx) VERVE-101 (@VerveTx ) BRL-103 (Bioray in China) & [--] CAR-T trials led by Waseem Qasim (University College of London) said @davidrliu at #ESGCT2023 h/t @KevinADavies Its easy to publish papers using poorly chosen guide RNAs & older-generation editing tools. Scientists should strive to use currently available editing reagents in such studies- said @davidrliu during #esgct2023 keynote in Brussels h/t @KevinADavies tweets Its easy to publish papers using poorly chosen guide RNAs &"
X Link 2023-10-25T11:32Z [----] followers, [----] engagements
"Amgen plans to lay off [---] workers at Horizon Therapeutics mostly in Deerfield IL following Amgens acquisition of Horizon [--] wks ago said @chicagotribune. Horizon had [---] of [----] employees based in Deerfield at time of sale. 20% of Horizon 2b laid off https://www.chicagotribune.com/business/ct-biz-horizon-layoffs-amgen-acquisition-20231024-2q3xnax74bf7ze7qieqjsxg2ie-story.html https://www.chicagotribune.com/business/ct-biz-horizon-layoffs-amgen-acquisition-20231024-2q3xnax74bf7ze7qieqjsxg2ie-story.html"
X Link 2023-10-25T12:01Z [----] followers, [---] engagements
"Philadelphia-based rare genetic disease biotech Aro Biotherapeutics raised $41.5M B led by Cowen Healthcare Investments w/participation from J&J Innovation/JJDC Northpond Healthcap & BVF https://www.arobiotx.com/aro-bio-secures-41m-series-b-financing https://www.arobiotx.com/aro-bio-secures-41m-series-b-financing"
X Link 2023-11-28T23:47Z [----] followers, [----] engagements
"Biotech VC @UcianeScarlett PhD of MPM Capital will discuss her career trajectory & answering Q&A today at 5:00 PM ET on @thebiotechclub Zoom below. Prior to MPM she was a VC at Atlas & Oxford Sciences Enterprise. Prior to that she was business development dir at Compass Tx Do you want to learn how to navigate a high-impact career in life sciences If so please join us for a conversation with @UcianeScarlett from @MPMCapital tomorrow November 29th at 5pm to learn about pursing a career in venture capital and biotech investment https://t.co/m0HnDSkUWX Do you want to learn how to navigate a"
X Link 2023-11-29T16:55Z [----] followers, [----] engagements
"39% of biotech organizations report anticipating searching for executive talent. 17% anticipate using fractiona executives (outsourced as-needed or part-time execs)"
X Link 2024-01-25T19:56Z [----] followers, [---] engagements
"Vertex plans to buy Seattle-based Alpine Immune Sciences$4.9B in cash incl investigational drug entering Phase [--] that's shown promise in treating IgA nephropathy autoimmune disorder of the kidney that can lead to end-stage renal disease & affects [------] people in US $ALPN $VRTX Congrats to all involved https://twitter.com/i/web/status/1778164597565825410 https://twitter.com/i/web/status/1778164597565825410"
X Link 2024-04-10T20:54Z [----] followers, [----] engagements
"Here's the link to the @statnews story by @matthewherper $VRTX $ALPN https://www.statnews.com/2024/04/10/vertex-to-buy-alpine-immune-sciences/ https://www.statnews.com/2024/04/10/vertex-to-buy-alpine-immune-sciences/"
X Link 2024-04-10T20:55Z [----] followers, [---] engagements
"The award for Clinical Research Team Of The Year went to Agios Pharmaceuticals team for the [---] ENERGIZE trial of mitapivat for thalassemia $AGIO. "The team exceeded enrollment targets and completed the pivotal Phase III study ahead of schedule. Proactively engaging with patient advocacy groups they ensured protocols reflected patient challenges culminating in historic results: meeting primary and secondary endpoints and demonstrating mitapivats potential to transform thalassemia treatment the firm said adding that their cross-functional collaboration has set a new standard in rare disease"
X Link 2024-05-09T14:42Z [----] followers, [----] engagements
"SF-based extracellular protein degradation biotech & Lilly collaborator @LyciaTx is prepping to enter clinical trials w/ $106.6M C round led by Venrock w/participation from Versant RTW Cowen & more. Co-founder is Nobel laureate @CarolynBertozzi CEO is Aetna Wun Trombley. Congrats https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/ https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/ https://endpts.com/carolyn-bertozzi-founded-lycia-therapeutics-raises-106m-to-enter-the-clinic/"
X Link 2024-05-13T19:46Z [----] followers, [----] engagements
""The FDA issued a Warning Letter to Cue Health on May [--] [----] after an inspection revealed the company made changes to these tests and these changes reduced the reliability of the tests.""
X Link 2024-05-14T16:31Z [----] followers, [---] engagements
"With Calico's announcement today it looks like FDA's Operation Warp Speed program for rare diseases picked their initial [--] candidates: Moderna Denali Therapeutics Larimar Therapeutics Grace Science Neurogene Myrtelle & now Calico. Operation Warp Speed for Covid in '20 had 8"
X Link 2024-06-07T21:36Z [----] followers, [----] engagements
""Recent discoveries have highlighted the role of microglial signaling & neuroinflammation in neurodegenerative diseases. TREM2 is a well credentialed microglia target in this context said Erik Wallstroem $SNY Sanofi's Global Head of Neurology Development. $VIGL In connection with the equity investment Vigil has granted Sanofi the exclusive right of first negotiation for an exclusive license grant or transfer of rights to research develop manufacture and commercialize the Vigils small molecule TREM2 agonist program including its clinical candidate VG-3927. VG-3927 is currently being evaluated"
X Link 2024-06-27T11:40Z [----] followers, [----] engagements
"@Jasonmmast Interesting. if the data isn't very good will patients & parents (& payers) wait a little longer for Solid or Regenxbio"
X Link 2024-07-02T13:24Z [----] followers, [--] engagements
"I wanted to note that the PBM situation became worse for consumers & independent pharmacies in recent yrs after the '18 mergers of CVS & Aetna (CVS/Aetna/Caremark) and Cigna & Express Scripts. (Cigna/Express Scripts/Accredo). Members of previous cabinet like Pompeo have been publicly speaking out against the FTC interim report https://twitter.com/i/web/status/1811116203345334359 https://twitter.com/i/web/status/1811116203345334359"
X Link 2024-07-10T19:12Z [----] followers, [---] engagements
"This is @ADeAngelis_bio's story about Curie Bio when they announced their 2nd or 3rd fund [--] wks ago. If you're a scientist starting a company or thinking about itthey're a good group to talk to: https://www.statnews.com/2024/06/26/curie-bio-accelerator-new-fund/ https://www.statnews.com/2024/06/26/curie-bio-accelerator-new-fund/"
X Link 2024-07-11T23:14Z [----] followers, [---] engagements
"This is @GabrielleMasso9's story in @FierceBiotech about Curie Bio also from [--] wks ago (open access): https://www.fiercebiotech.com/biotech/alexis-borisy-founded-vc-raises-380m-early-stage-biotechs https://www.fiercebiotech.com/biotech/alexis-borisy-founded-vc-raises-380m-early-stage-biotechs"
X Link 2024-07-11T23:17Z [----] followers, [---] engagements
"New addition to clinical stage biotech's mgmt team incl EMD Serono & Alpine Immune Sciences alum Christof Marr as SVP Commercial.@VedantaBio is progressing Phase [--] & [--] trials for diseases below w/product engine incl large library of bacteria isolated from human microbiome $PRTC Today our Founded Entity @VedantaBio announced the expansion of its leadership team as the company progresses its Phase [--] trial for #Cdiff and Phase [--] trial for #ulcerativecolitis and builds its commercial function https://t.co/iyxH8gpk0B https://t.co/XeImsW0owt Today our Founded Entity @VedantaBio announced the"
X Link 2024-07-25T22:36Z [----] followers, [---] engagements
"Royalty Pharma $RPRX announced in May that they had acquired an interest in Agios $AGIO royalty on Serviers vorasidenib for $905M in upfront cash contingent on FDA's approval of vorasidenib. The 1st targeted therapy in IDH-mutant glioma a progressive & incurable brain tumor"
X Link 2024-08-06T21:42Z [----] followers, [----] engagements
"Royalty Pharma said at the time (May '24) that they projected $1B in peak sales annually for vorasidenib in US w/ potential to generate royalties exceeding $150M annually: https://www.royaltypharma.com/news/royalty-pharma-and-agios-pharmaceuticals-enter-into-vorasidenib-royalty-agreement-for-905-million/ https://www.royaltypharma.com/news/royalty-pharma-and-agios-pharmaceuticals-enter-into-vorasidenib-royalty-agreement-for-905-million/"
X Link 2024-08-06T21:44Z [----] followers, [---] engagements
"Clinical stage gene editing biotech focused on CRISPR-based therapies recruited Alexion & Shire alum Maria Natale to be $NTLA's SVP Commercial. Most recently she was Galderma's Global Franchise Head of Immunology. At Shire/Takeda she was the US launch lead for hereditary angiodema drug Takhzyro & was the global commercial of the hematology franchise. You can read more about her hematology experience at Baxalta/Baxter & at the other employers on the website Excited to announce the newest member of our leadership team Maria Natale senior vice president of Commercial. With over [--] years of"
X Link 2024-08-21T11:30Z [----] followers, [---] engagements
"Anthems demand for $ is highly unusual & seems weird said @jlevinscherz managing dir at Willis Towers Watson @WTWcorporate who advises employers on health coverage. Ive never heard of a carrier billing a physician for procedures or a medicine that was provided by someone else. https://twitter.com/i/web/status/1835479467520655422 https://twitter.com/i/web/status/1835479467520655422"
X Link 2024-09-16T00:43Z [----] followers, [----] engagements
"This sounds like fun at the JPM healthcare conference in Jan but I also hope action has been taken since Jan '24 on making sure that nursing moms attending the conference (incl journalists) have a better experience this time. See below for @statnews story by @TaraBannow 1/n This year among a sea of black suits we are going to add a splash of color. You dont have to be one of the almost [---] #BiotechCEOSisters to wear pink at #JPM2025. Pink ties socks and scarves also welcome Tuesday January 14th [----] https://t.co/foiY5vk3Xe This year among a sea of black suits we are going to add a splash of"
X Link 2024-10-13T22:02Z [----] followers, [----] engagements
"This is the story by @TaraBannow I referenced above. The suggestion that women in the biopharmaceutical industry who are nursing "need to stay home" needs to change: https://www.statnews.com/2024/01/11/jpm24-pumping-space-women-health-care-biotech/ https://www.statnews.com/2024/01/11/jpm24-pumping-space-women-health-care-biotech/"
X Link 2024-10-13T22:06Z [----] followers, [----] engagements
""STAT6 is a historically undrugged essential transcription factor in the IL-4/IL-13 signaling pathways & the central driver of T helper type [--] (TH2) inflammation in allergic diseases.KT-621 is an investigational first-in-class once daily oral STAT6 degrader with dupilumab-like activity in preclinical models & the potential to address multiple allergic & atopic diseases including atopic dermatitis asthma and chronic obstructive pulmonary disease among others." Proud of the team @KymeraTx for this monumental milestone This is a great day for our industry: first in human for a STAT6 directed"
X Link 2024-10-24T12:18Z [----] followers, [---] engagements
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