# ![@KarlPfleger Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1242572367928291330.png) @KarlPfleger Karl Pfleger

Karl Pfleger posts on X about in the, list, the most, health the most. They currently have [-----] followers and [---] posts still getting attention that total [--] engagements in the last [--] hours.

### Engagements: [--] [#](/creator/twitter::1242572367928291330/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1242572367928291330/c:line/m:interactions.svg)

- [--] Week [-----] +216%
- [--] Month [-----] +58%
- [--] Months [------] -83%
- [--] Year [-------] -66%

### Mentions: [--] [#](/creator/twitter::1242572367928291330/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1242572367928291330/c:line/m:posts_active.svg)

- [--] Week [--] no change
- [--] Month [--] +32%
- [--] Months [---] +22%
- [--] Year [---] +33%

### Followers: [-----] [#](/creator/twitter::1242572367928291330/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1242572367928291330/c:line/m:followers.svg)

- [--] Week [-----] +0.50%
- [--] Month [-----] +1.30%
- [--] Months [-----] +8.50%
- [--] Year [-----] +23%

### CreatorRank: undefined [#](/creator/twitter::1242572367928291330/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1242572367928291330/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[finance](/list/finance)  4% [stocks](/list/stocks)  3% [technology brands](/list/technology-brands)  2% [currencies](/list/currencies)  2% [celebrities](/list/celebrities)  1% [nhl](/list/nhl)  1% [social networks](/list/social-networks)  1%

**Social topic influence**
[in the](/topic/in-the) 17%, [list](/topic/list) 10%, [the most](/topic/the-most) 7%, [health](/topic/health) 6%, [ai](/topic/ai) 4%, [science](/topic/science) 4%, [to the](/topic/to-the) 4%, [this is](/topic/this-is) 4%, [talk](/topic/talk) 4%, [study](/topic/study) 4%

**Top accounts mentioned or mentioned by**
[@jpsenescence](/creator/undefined) [@aubreydegrey](/creator/undefined) [@bryanjohnson](/creator/undefined) [@randlongevity](/creator/undefined) [@recoverydoctor](/creator/undefined) [@maxunfried](/creator/undefined) [@gladyshevlab](/creator/undefined) [@michaelrossen](/creator/undefined) [@adamgries](/creator/undefined) [@elander777](/creator/undefined) [@ericdaibioe](/creator/undefined) [@erictopol](/creator/undefined) [@ukbiobank](/creator/undefined) [@scienceadvances](/creator/undefined) [@ajpendometab](/creator/undefined) [@gidmk](/creator/undefined) [@foresightinst](/creator/undefined) [@drjbhattacharya](/creator/undefined) [@francesconeri](/creator/undefined) [@nickschaum](/creator/undefined)

**Top assets mentioned**
[HCW Biologics Inc. (HCWB)](/topic/$hcwb) [Alphabet Inc Class A (GOOGL)](/topic/$googl)
### Top Social Posts
Top posts by engagements in the last [--] hours

"@bryan_johnson How heavy Many communities are studied for long healthy lifespans (eg Blue Zones). Do any of such cultures frequently lift heavy things Gardening & walking/hiking seems like common activities. Pumping iron Any communities known for heavy lifting known for long lifespans"  
[X Link](https://x.com/KarlPfleger/status/2020974336547619130)  2026-02-09T21:33Z [----] followers, [----] engagements


"Last week my shortest podcast interview dropped (Decoding Longevity). This week here's my longest just out (Free Radicals). Great wide-ranging conversation covering the aging biotech sector & companies getting to approvals but also how to think about stuff available now. For our 10th episode of the Free Radicals podcast @EricDai_BioE and I are excited to host @KarlPfleger After a decade as one of the first AI researchers at Google from [----] to [----] Karl dedicated himself to the cause of rejuvenation biotechnology. He is a philanthropist https://t.co/o6i9mfljqm For our 10th episode of the Free"  
[X Link](https://x.com/KarlPfleger/status/2021644088987234796)  2026-02-11T17:54Z [----] followers, [----] engagements


"@RecoveryDoctor [--] out of 250+ top people in the aging/longevity field appear in the files. See for a list of 248+ people who don't. Attia doesn't represent the field. He's a commentator who focuses too little on the stuff that really matters: new therapies yet to arrive. http://AgingBiotech.info/people http://AgingBiotech.info/people"  
[X Link](https://x.com/KarlPfleger/status/2021999420221575357)  2026-02-12T17:26Z [----] followers, [---] engagements


"@EricTopol @uk_biobank @ScienceAdvances [--] points: (A) BMIs 25.5-8. Lower BMIs would improve health more so looks like this only shows gain by changing what's eaten not how much. suggests overall gain bigger. (B) They compared quintiles so healthiest 10% or 5% may give even more gain. https://x.com/KarlPfleger/status/1632518657673945089 New paper shows that when you take into account BMI over the past [--] years not just at present time (and take into account confounders) then low-normal BMI looks healthiest with monotonic (roughly linear) increase in risk with increasing BMI. Here's the key"  
[X Link](https://x.com/KarlPfleger/status/2022394983433781471)  2026-02-13T19:38Z [----] followers, [---] engagements


"Just launched: The set of aging-related podcasts grew a lot recently w/ launches of Longevity Biotech Show Translating Aging Foresight's & BioVerge's. Worthy of being a list now. Good stuff that can be listened to while walking driving exercising etc. http://AgingBiotech.info/podcasts http://AgingBiotech.info/podcasts"  
[X Link](https://x.com/KarlPfleger/status/1418648559725858816)  2021-07-23T19:05Z [----] followers, [---] engagements


"Just launched: A steady trickle of popular books on aging/longevity the past decade+ turned to a steady stream past few years. I collected those popular enough (# ratings) & good enough (min avg rating). Most avail. as audio. Everyone should read a couple. http://AgingBiotech.info/books http://AgingBiotech.info/books"  
[X Link](https://x.com/KarlPfleger/status/1426947223007514634)  2021-08-15T16:41Z [----] followers, [--] engagements


"Aging causes 70+% of all deaths 100k+ deaths/day and tortures everyone after middle age w/ degeneration & multimorbidity. Also makes people susceptible to infection inc Covid. It is an URGENT problem. Fast research grants for it very appropriate. Great looking new program. Thrilled to announce the Longevity #Impetus Grants $21M+ towards basic research that could accelerate our understanding and control of human aging. We welcome proposals from researchers in- and outside the #Aging field. Please share More info: https://t.co/2fvZv96lL9 & this 🧵 Thrilled to announce the Longevity #Impetus"  
[X Link](https://x.com/KarlPfleger/status/1435384413374717961)  2021-09-07T23:28Z [----] followers, [--] engagements


"July peer reviewed paper shows vitamin D metabolites directly inhibit SARS-CoV-2 replication. Now APS (Amer. Physiological Soc.) picks it as Sept APSselect article. Another in long line of science showing how D can influence Covid. When will authorities make officials D recs 1/ Congratulations to the @AJPEndoMetab September #APSselect winner Vitamin D and lumisterol novel metabolites can inhibit SARS-CoV-2 replication machinery enzymes by Qayyum et al. https://t.co/pThDkXzcGp https://t.co/wkszERgOaq Congratulations to the @AJPEndoMetab September #APSselect winner Vitamin D and lumisterol"  
[X Link](https://x.com/KarlPfleger/status/1436390675415584774)  2021-09-10T18:06Z [----] followers, [--] engagements


"@GidMK No bad studies invalidate undisputed facts: (1) D deficiency rates are 10x+ higher than they should be. (2) D regulates hundreds of genes involved in innate & adaptive immune function. (3) D correlates w/ Covid outcomes. (4) The NOAEL is 10k IU/d. Balance of risk seems clear"  
[X Link](https://x.com/KarlPfleger/status/1440072014119661568)  2021-09-20T21:54Z [----] followers, [--] engagements


"Mouse lemurs mouse-like primates a better model species than mice Lifespans like dogs. Quick breeding. Naturally suffer aging diseases: AD/dementias cancer strokes atherosclerosis. Time to check for senescent cells Who'll do a rapamycin study https://www.economist.com/science-and-technology/a-tiny-primate-may-join-the-ranks-of-the-worlds-model-organisms/21806681 https://www.economist.com/science-and-technology/a-tiny-primate-may-join-the-ranks-of-the-worlds-model-organisms/21806681"  
[X Link](https://x.com/KarlPfleger/status/1471247920674398210)  2021-12-15T22:36Z [----] followers, [--] engagements


"I invest in biotech startups in aging/longevity & had the pleasure of doing a Q&A on this hosted by the Foresight Institute @foresightinst. Here's the video: More background on why this is important & my motivation to work on this: https://agingbiotech.info/about/aging_motivation.html https://www.youtube.com/watchv=O2SrRjbwWJ4 https://agingbiotech.info/about/aging_motivation.html https://www.youtube.com/watchv=O2SrRjbwWJ4"  
[X Link](https://x.com/KarlPfleger/status/1484244809288073216)  2022-01-20T19:21Z [----] followers, [--] engagements


"At this point it is beyond question that Vitamin D Deficiency (VDD) is a significant risk factor for Covid just like age obesity comorbidities. Many dozens of studies show this & correlation-doesn't-imply-causation isn't a valid objection to classification as a risk factor. 🧵"  
[X Link](https://x.com/KarlPfleger/status/1486565564671692804)  2022-01-27T05:03Z [----] followers, [---] engagements


"CORONAVIT trial (vitamin D supplements for Covid prevention) results are negative but the implications are narrow and must not be misinterpreted. This was a well done trial in many ways. Here's what is reasonable to conclude from it & what isn't: https://www.medrxiv.org/content/10.1101/2022.03.22.22271707v1 https://www.medrxiv.org/content/10.1101/2022.03.22.22271707v1"  
[X Link](https://x.com/KarlPfleger/status/1506871284214337543)  2022-03-24T05:51Z [----] followers, [---] engagements


"1. Vitamin D supplements protect against having a severe Covid case (eg hospitalization ICU or death). A trial with vastly more hospitalization events would be required to examine this question"  
[X Link](https://x.com/KarlPfleger/status/1506871288568057862)  2022-03-24T05:51Z [----] followers, [--] engagements


"New vitamin D prophylactic RCT for Covid infection: 1st placebo controlled & 1st blinded such RCT. & multicenter (4 hospitals) so ticks all good RCT boxes. 4000IU/d Huge effect size: RR 0.23; 95% CI 0.090.55 77% reduction (95% confidence of 45% lower) 🧵 https://www.sciencedirect.com/science/article/pii/S0188440922000455 https://www.sciencedirect.com/science/article/pii/S0188440922000455"  
[X Link](https://x.com/KarlPfleger/status/1516918243390156800)  2022-04-20T23:14Z [----] followers, [---] engagements


"My most important threads a meta-thread list: (Many peoples' pinned Tweets should probably be a list of multiple pin-worthy threads.) I mostly talk about the aging/longevity/rejuvenation field vitamin D & Covid-19 and sometimes the intersections of these things"  
[X Link](https://x.com/KarlPfleger/status/1517275742786113538)  2022-04-21T22:55Z [----] followers, [--] engagements


"Yet another study shows vitamin D status predicts clinical Covid outcome: This doesn't prove D as a treatment but this & similar data justify testing all hospitalized Covid patients' D level to help predict severity. Test is cheap & fast & doesn't harm. https://pubmed.ncbi.nlm.nih.gov/35871942/ https://pubmed.ncbi.nlm.nih.gov/35871942/"  
[X Link](https://x.com/KarlPfleger/status/1553942178430320641)  2022-08-01T03:14Z [----] followers, [--] engagements


"There are now (at min) [--] big systematic meta-analyses of vitamin D & Covid since Dec'21. [--] study D levels & [--] supplementation. Newest both. Strong consistent & highly statistically significant results: Low D raises & supplementation lowers all stages of Covid risk by 1.5-3x 🧵"  
[X Link](https://x.com/KarlPfleger/status/1557814485070409728)  2022-08-11T19:41Z [----] followers, [---] engagements


"Highly recommend the most recent good review of mechanisms of action of vitamin D affecting Covid risk by notable Irish researchers who've published in the area throughout the pandemic. Notable: Directly addresses satisfying Hill's Criteria for causation. https://pubmed.ncbi.nlm.nih.gov/35308241/ https://pubmed.ncbi.nlm.nih.gov/35308241/"  
[X Link](https://x.com/KarlPfleger/status/1564748215512993792)  2022-08-30T22:53Z [----] followers, [---] engagements


"@DrJBhattacharya Booster requirements based on shot count w/o regard to recency of last dose are now indefensible as are rules not counting prior infections (for non elderly/immunocompromised). Good new Aug31 NEJM review No evidence boosting long ago reduces transmission. https://www.nejm.org/doi/full/10.1056/NEJMra2206573 https://www.nejm.org/doi/full/10.1056/NEJMra2206573"  
[X Link](https://x.com/KarlPfleger/status/1566076363160764416)  2022-09-03T14:51Z [----] followers, [---] engagements


"Huge new US study (250+k patients 400+k controls): "When we extrapolate our results for vitamin D3 supplementation to the entire US population in [----] there would have been approximately [--] million fewer COVID-19 cases and [------] deaths avoided." https://www.nature.com/articles/s41598-022-24053-4 https://www.nature.com/articles/s41598-022-24053-4"  
[X Link](https://x.com/KarlPfleger/status/1602824529205596162)  2022-12-14T00:35Z [----] followers, [--] engagements


"New list of aging related databases just launched: collects over a dozen useful available datasets. Credit goes to @FrancescoNeri_ who compiled the table. What else belongs on this list that's missing http://AgingBiotech.info/databases http://AgingBiotech.info/databases"  
[X Link](https://x.com/KarlPfleger/status/1603543033584107520)  2022-12-16T00:10Z [----] followers, [----] engagements


"@Nick_Schaum @jpsenescence @ArtirKel @MaxUnfried @aubreydegrey So then it seems for the moment is the only org pushing full speed ahead on testing combos of aging interventions w/ specific intention of seeing how to get maximum effectiveness. @senstweet was going to do this. I wonder if they still will soon too. http://LEVF.org http://LEVF.org"  
[X Link](https://x.com/KarlPfleger/status/1603569776692903940)  2022-12-16T01:56Z [----] followers, [----] engagements


"Years in the works but much delayed new list of aging/longevity related nonprofits launched: lists 40+ nonprofits w/ 500+ people. [----] was a bad financial year & ends in [--] days. Many of these orgs could use more donations in [----]. Maybe this can help. 1/ http://AgingBiotech.info/nonprofits http://AgingBiotech.info/nonprofits"  
[X Link](https://x.com/KarlPfleger/status/1605235042241781760)  2022-12-20T16:13Z [----] followers, 11.5K engagements


"What investors have invested in multiple aging/longevity companies New table summarizes for repeat aging investors & companies. #JPM23 next week so seems a good time to launch. What repeat investors w/ public portfolios are missing Important notes: http://AgingBiotech.info/investorsXcompanies http://AgingBiotech.info/investorsXcompanies"  
[X Link](https://x.com/KarlPfleger/status/1611446701373652992)  2023-01-06T19:36Z [----] followers, [----] engagements


"People are working on this eg: The Last Generation to Die (2015) & documentaries like Longevity Hackers & Ron Howard's Age of Aging episode of Breakthrough. But right now these reach far fewer people than blockbusters like Avatar. That needs to change. https://www.longevityhackers.tv/ https://www.longevityhackers.tv/"  
[X Link](https://x.com/KarlPfleger/status/1616167649180016645)  2023-01-19T20:16Z [----] followers, [---] engagements


"Note also that unlike the survey mentioned in the article people do generally say they want to live longer when the question specifies good health as several of us including Kristen Fortney of BioAge and Joe Betts-LaCroix of Retro demonstrated in 2016: https://www.frontiersin.org/articles/10.3389/fgene.2015.00353/full https://www.frontiersin.org/articles/10.3389/fgene.2015.00353/full"  
[X Link](https://x.com/KarlPfleger/status/1616167650274717697)  2023-01-19T20:16Z [----] followers, [---] engagements


"New 10yr 12000-person study shows vitamin D reduces risk of dementia by 40% a huge effect size & very stat significant: HR 95%CI 0.550.65 WebMD's coverage summarized results as 75% who didnt take vitamin D got dementia in 10yrs vs 25% who took D. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12404 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12404"  
[X Link](https://x.com/KarlPfleger/status/1631810776020426753)  2023-03-04T00:16Z [----] followers, [----] engagements


"People in the field should stop wasting time on social media when Elon is negative on the aging field. He's been corrected & it hasn't changed his mind. Let him get on w/ EVs space etc & let's get on w/ the real work & stop wasting time on social after he comments on longevity"  
[X Link](https://x.com/KarlPfleger/status/1645532381481406467)  2023-04-10T21:01Z [----] followers, [----] engagements


"Announcing a categorization of [--] categories of aging/longevity companies & mappings between this the SENS areas Hallmarks & Pillars: Categorization is hard & often contentious but important enough to be worth trying even if the result is imperfect. A 🧵 https://docs.google.com/spreadsheets/d/1zU-jrPthw-aYLjlY_1gJ0eH8rFNeOlSSjJJT1altdq8/edit#gid=0 https://docs.google.com/spreadsheets/d/1zU-jrPthw-aYLjlY_1gJ0eH8rFNeOlSSjJJT1altdq8/edit#gid=0"  
[X Link](https://x.com/KarlPfleger/status/1650677266442252288)  2023-04-25T01:45Z [----] followers, [----] engagements


"Data from the new TargetD trial suggests that prior vitamin D trials were flawed: Many people even professionals still think vitamin D was a false profit that was disproven by big RCTs. This view is very flawed for several reasons. A brief history: https://www.news-medical.net/news/20231113/Current-vitamin-D-dosing-recommendations-not-high-enough-for-optimal-heart-health-studies-suggest.aspx https://www.news-medical.net/news/20231113/Current-vitamin-D-dosing-recommendations-not-high-enough-for-optimal-heart-health-studies-suggest.aspx"  
[X Link](https://x.com/KarlPfleger/status/1732514710715514883)  2023-12-06T21:37Z [----] followers, 41.4K engagements


"The aging field doesn't discuss enough the key top-level distinction between the [--] main therapeutic paradigms: slow aging or reverse it. I support slowing aging as much better than traditional medicine but it pains me to see many in the field disparage or ignore reversal & I think there should be more open discussion of this distinction. Aging is a slow progressive set of molecular changes. The differences between slowing it vs undoing it have important implications that aren't acknowledged enough. Many slow-aging therapies slow most/all the changes w/ [--] approach. In contrast rejuvenation is"  
[X Link](https://x.com/KarlPfleger/status/1736108328743489903)  2023-12-16T19:37Z [----] followers, 30.6K engagements


"Announcing a big update of a small list: List of podcasts in the aging/longevity biotech field at just overhauled: - several new shows added (up to [--] total now) - clearer description of to what extent each is topically on-target for aging biotech - global popularity score & counts of ratings on the major podcast platforms as backups - recency score based on months since last episode - aggregate ranking combining the above (default sort) Manually sortable by any column (like all the tables on the site). There's a tradeoff between topicality & popularity here: The hard science & biotech"  
[X Link](https://x.com/KarlPfleger/status/1747707749205750062)  2024-01-17T19:49Z [----] followers, 10.3K engagements


"List of video channels about aging just fully updated at [--] total Importantly several are outlets for talk videos from aging conferences. [--] confs represented currently. Any other notable aging/longevity confs w/ videos online that this list misses http://AgingBiotech.info/videos http://AgingBiotech.info/videos"  
[X Link](https://x.com/KarlPfleger/status/1749832206594584869)  2024-01-23T16:31Z [----] followers, [----] engagements


"@enhanced_games How do the organizers encourage good-for-the-athlete's-long-term-health enhancements while discouraging terrible-fo-the-athlete's-health enhancements like steroids"  
[X Link](https://x.com/KarlPfleger/status/1752719575094104459)  2024-01-31T15:44Z [----] followers, 10.4K engagements


"Many of the level-headed folks advocating for age-reversal strategies over age-slowing ones including me would agree with you that claims of having accomplished age-reversal already are surprising. Part of the litmus test should be ability to re-apply the treatment repeatedly every so-many years (humans) or months (rodents) to repeatedly demonstrate reversal of many of the slowing accumulating biomolecular changes of aging. (And to his credit this is the way Aubrey has often described "damage repair 1.0" when discussing the hypothetical future achievement of longevity escape velocity which no"  
[X Link](https://x.com/KarlPfleger/status/1755788089870684373)  2024-02-09T02:57Z [----] followers, [----] engagements


"Obesity is the hot topic in biotech/pharma right now. Alas I fear this may be a bad thing for the aging field something that sidetracks the field. I'm prob one of the few not to fully celebrate BioAge's recent huge series D round. I'm good friends with the company & happy for its growth & funding but the accompanying pivot to obesity is disappointing to me. Obviously this helped unlock the money so maybe the tradeoff is worth it if it helps fund the field or catapult it to wider recognition & acceptance. Jury is still out on those. But I hate obesity & metabolic diseases (ie T2D) as"  
[X Link](https://x.com/KarlPfleger/status/1763007442487746715)  2024-02-29T01:05Z [----] followers, 36.1K engagements


"Want to track aging/longevity clinical trials Several sites have made lists. With @ScheibyeKnudsen's new AgingDB it's time for a meta-list to collect them all: Announcing Diffs noted in the columns. Hopefully a few of these will be updated regularly. http://AgingBiotech.info/trials http://AgingBiotech.info/trials"  
[X Link](https://x.com/KarlPfleger/status/1765049670362091578)  2024-03-05T16:20Z [----] followers, [----] engagements


"Looking for opportunities in the aging/longevity field Looking for fellowships internships summer programs undergrad research opportunities or other ways to contribute to the field Announcing a new table for these & other options (not quite jobs). http://AgingBiotech.info/opportunities http://AgingBiotech.info/opportunities"  
[X Link](https://x.com/KarlPfleger/status/1767200100017914241)  2024-03-11T14:45Z [----] followers, [----] engagements


"Apparent contradictions in aging research: More or less oxygen More or less taurine More or less protein Late-life mTOR/protein/rapamycin up or down What else A thread"  
[X Link](https://x.com/KarlPfleger/status/1769766685060337812)  2024-03-18T16:43Z [----] followers, 13.2K engagements


"Artificial Intelligence as a field has much in common with the aging/longevity field. I hadn't realized how many parallels until thinking about it this week. (These are my former & current fields respectively.) A list of similarities:"  
[X Link](https://x.com/KarlPfleger/status/1772690306523107619)  2024-03-26T18:21Z [----] followers, [----] engagements


"Much anxiety recently about overhype in aging/longevity esp disdain for sloppy language equating lower aging clocks (biological age estimates) w/ true rejuvenation. Sometimes it's useful to look at history & sometimes at other fields. Perhaps this might add perspective. A 🧵"  
[X Link](https://x.com/KarlPfleger/status/1772712738474676352)  2024-03-26T19:50Z [----] followers, [----] engagements


"Why I'm cautiouslyoptimistic on rejuvenation progress: The aging/longevity field's goal is best-possible healthfor as long as possible for as many people as possible. High level approaches are SLOW aging rate or REJUVenate (reverse) each of aging's molecular changes (damage)"  
[X Link](https://x.com/KarlPfleger/status/1775249561386455104)  2024-04-02T19:50Z [----] followers, [----] engagements


"Great week in aging biotech news thanks to Rubedo Repair & Gordian (🧵1/6): Rubedo raises $40M for its sophisticated senolytic platform w/ participation of many important investors (& me) notably being one of the first few investments by Hevolution. https://x.com/LongevityTech/status/1782379329155940365 Rubedo lands $40m to advance senescence-targeting therapeutics into clinical trials. Longevity biotech @LifeRubedo plans Phase [--] #senotherapeutics trial this year as it seeks to keep people biologically young. #longevity #investment #senescence https://t.co/dp07wVlvUV"  
[X Link](https://x.com/KarlPfleger/status/1783963517634379857)  2024-04-26T20:57Z [----] followers, [----] engagements


""Do no harm" & "safety first" should be abandoned in medicine due to inadequate consideration of the harms of inaction which can be substantial & also likely. A switch to decision theory or a similar form of optimization under uncertainty as overt guiding principle is overdue"  
[X Link](https://x.com/KarlPfleger/status/1785046981637001475)  2024-04-29T20:42Z [----] followers, [----] engagements


"@aubreydegrey & @fedichev debated whether rejuvenation (reversal of biological age) is possible or not on 2024/5/27. Below is my summary personal take & [--] suggested topics for further discussion plus a few more detailed notes. Full 3hr video: https://youtu.be/g7UwkfoLO5s https://youtu.be/g7UwkfoLO5s"  
[X Link](https://x.com/KarlPfleger/status/1795594992062497277)  2024-05-28T23:16Z [----] followers, [----] engagements


"Announcing: (beta) a table of most available (potential) aging therapeutics: supplements drugs lifestyle etc. The goal isn't to judge or rank them but to summarize other evaluations & link useful sources of details. Important notes: 🧵 http://AgingBiotech.info/therapeutics http://AgingBiotech.info/therapeutics"  
[X Link](https://x.com/KarlPfleger/status/1803578818596315286)  2024-06-20T00:01Z [----] followers, [----] engagements


"@samuel_spitz sleep: 8hrs/dy work: 50hr/wk lift: 120min/wk cardio: 150min/wk 10k steps: no extra time cook: 60min/dy dress: 30min/dy (2 changes to exercise) iron: zero (wrong clothes) read before bed: 10min/dy Leaves 18.8hr/wk for friends/fam dates chores rec. [----] even w/ 1hr/dy commute"  
[X Link](https://x.com/KarlPfleger/status/1805822279475249611)  2024-06-26T04:35Z [----] followers, 12.7K engagements


"I've now finished Michael Greger's big 640-page book How Not To Age It's now BY FAR my top rec of books on lifestyle for health & slowing aging. It's also a great intro to aging biology. Short 🧵 w/ a slightly more detailed review: https://www.amazon.com/How-Not-Age-Scientific-Healthier/dp/1250796334 https://www.amazon.com/How-Not-Age-Scientific-Healthier/dp/1250796334"  
[X Link](https://x.com/KarlPfleger/status/1806419016111812780)  2024-06-27T20:07Z [----] followers, [----] engagements


"Direct-to-consumer aging clocks give very inconsistent answers. I tried TruDiagnostic Elysium GlycanAge & reg blood draw for PhenoAge on same day in Feb & from same venous blood draw at LabCorp except Elysium's uses saliva which I did right before going to LabCorp. Notes: 🧵"  
[X Link](https://x.com/KarlPfleger/status/1807790438822387917)  2024-07-01T14:56Z [----] followers, 30.1K engagements


"Wondering who to follow in aging/longevity Or to read/listen-to Want to know the movers & shakers Announcing A list of noteworthy people in the field prob worth following objectively synthesized f/ several sources & signals. Key notes & details: http://AgingBiotech.info/people http://AgingBiotech.info/people"  
[X Link](https://x.com/KarlPfleger/status/1810354745833566255)  2024-07-08T16:46Z [----] followers, 11.1K engagements


"I signed the new petition to create the National Institute for Longevity and Aging Research (NILAR) I included the following comment: https://a4li.org/support-nilar/ https://a4li.org/support-nilar/"  
[X Link](https://x.com/KarlPfleger/status/1820848649355604039)  2024-08-06T15:45Z [----] followers, 19.2K engagements


"Aging directly causes most of these so let me fix the fig for you. Recent changes don't look too noteworthy when looked at this way: 2019: aging aging injuries aging aging aging aging aging mostly aging suicide aging 2021: aging aging aging injuries aging aging aging aging aging aging suicide mostly aging 2023: aging aging injuries aging aging aging aging aging aging aging suicide mostly aging"  
[X Link](https://x.com/KarlPfleger/status/1821948395361333489)  2024-08-09T16:35Z [----] followers, [----] engagements


"Problem: Mice die of cancer disproportionately more than humans so lifespan results are confounded by anti-cancer mechanisms (MoAs). How hard would it be to create a strain of mice mostly immune to cancer If we did how long would they live And what would they mostly die of"  
[X Link](https://x.com/KarlPfleger/status/1825291312826110002)  2024-08-18T21:58Z [----] followers, [----] engagements


"New study on UV benefits even covered by the Economist UV - 19-23% less CVD mortality & 12-14% less cancer death risk corrected for age gender smoking socio-economic status & exercise n=360000 https://www.economist.com/science-and-technology/2024/08/12/exposure-to-the-suns-uv-radiation-may-be-good-for-you https://www.economist.com/science-and-technology/2024/08/12/exposure-to-the-suns-uv-radiation-may-be-good-for-you"  
[X Link](https://x.com/KarlPfleger/status/1825529871847874753)  2024-08-19T13:46Z [----] followers, [----] engagements


"I'm overhauling (long overdue). Occasionally I'm noticing stuff I hadn't realized. Eg: HCW Biologics' lead is in ph.2 for cancer but they think the bispecific molecule is also both senolytic & SASP suppressing. So. http://AgingBiotech.info/companies http://AgingBiotech.info/companies"  
[X Link](https://x.com/KarlPfleger/status/1826014340153253959)  2024-08-20T21:51Z [----] followers, [----] engagements


"New PEARL rapamycin study vs CALERIE mild (12%) CR study 🧵: CR & rapa both mTOR. But frustrating the designs aren't more apples-apples. Many things improved by [--] not reported in other. (Also unfortunate for both we don't have more direct biomarkers of mTOR pathway activity.)"  
[X Link](https://x.com/KarlPfleger/status/1828071477033554435)  2024-08-26T14:06Z [----] followers, [----] engagements


"Super exciting: the safe repeat-dosable good-delivery-not-just-to-liver gene therapy platform of Entos (& underlying Oisin Bio) now published & in high profile journal. This platform will do great things. And aging applications already in development. https://www.cell.com/cell/fulltext/S0092-8674%2824%2900783-9 https://www.cell.com/cell/fulltext/S0092-8674%2824%2900783-9"  
[X Link](https://x.com/KarlPfleger/status/1833707579211751634)  2024-09-11T03:22Z [----] followers, [----] engagements


"Short report: The state of the mitochondria portion of the aging biotech field: [--] companies $1.4+B raised 700+ people 150+ clinical trials many MoAs/targets: mitophagy transplant fission NAD+ UrolithinA CD38 PINK1 PPAR DRP1 USP30 Complex [--] OMA1 & more Read on:"  
[X Link](https://x.com/KarlPfleger/status/1835808096364662939)  2024-09-16T22:28Z [----] followers, 26.3K engagements


"Not all the data on extreme human aging is rotten. Saul Justin Newman's recent Ig Nobel for noting faked blue zone birth certificates generated overblown news & social media response that lacked wider perspective on other relevant data. A short thread: https://theconversation.com/the-data-on-extreme-human-ageing-is-rotten-from-the-inside-out-ig-nobel-winner-saul-justin-newman-239023utm_term=Autofeed&utm_medium=Social&utm_source=Twitter#Echobox=1726257638"  
[X Link](https://x.com/KarlPfleger/status/1837535246256165250)  2024-09-21T16:51Z [----] followers, [----] engagements


"Proud of Daniel & the Shift team. He pivoted to novel cell rejuvenation tx that optimized for rejuvenation w/o de-differentiation before Altos NewLimit & Jacob Kimmel's Calico talks on it. One of the most important sub-areas of the aging field. This round is great validation of what they've built & I'm super happy to be aboard (since 2021) & participating again in this latest round. (Fun personal milestone: my 50th investment deal in biotech startups with a particularly narrow focus on aging/longevity companies.) Shift Bio lands $16m to identify safe #rejuvenation genes. @ShiftBiosciences"  
[X Link](https://x.com/KarlPfleger/status/1846254039794962794)  2024-10-15T18:17Z [----] followers, [----] engagements


"The meme that senescent cells are sometimes good so we should be careful with senolytics is overdone. So far there's no good evidence of benefit from senescent cells (SnCs) that needs them to be long-lived.Thus applying too much caution to infrequent ablation by senolytics risks delaying substantial potential benefit. In showed periodic ablation of p16+ cells (an approximation of senescent cells) increased lifespan 25% w/ good health. This (& maybe a couple otherpapers around that time) kicked off the senolytics field. Since then there's been much work to develop senolytics & to characterize"  
[X Link](https://x.com/KarlPfleger/status/1846594154291515867)  2024-10-16T16:48Z [----] followers, [----] engagements


"Announcing version [---] a giant overhaul & update: - new columns - 50+ new companies - [---] companies fully up-to-date as of [----] inc. all of the most noteworthy - a new non-alphabetical default ordering based on rough significance (more on this below) . http://AgingBiotech.info/companies http://AgingBiotech.info/companies"  
[X Link](https://x.com/KarlPfleger/status/1848377862836937210)  2024-10-21T14:56Z [----] followers, [----] engagements


"There's controversy over whether aging should be classified as a disease. I'm doing a debate on it tonight. Complex question with many angles. Here's a document with thoughts from several perspectives to try to help move the global conversation forward: https://docs.google.com/document/d/1f5XF5FouhoLQTDmONHTwPmUbhXSJ2YHQDLl6p0wonm0/editusp=sharing https://docs.google.com/document/d/1f5XF5FouhoLQTDmONHTwPmUbhXSJ2YHQDLl6p0wonm0/editusp=sharing"  
[X Link](https://x.com/KarlPfleger/status/1849600707684667574)  2024-10-24T23:55Z [----] followers, 65.7K engagements


"Surprises me so many (n=57) agree a consensus def of aging is essential. Do they think AI field achieved consensus def of intelligence before its huge gains It didn't. No consensus porn def either. Famously only know-it-when-you-see-it. Didn't stop creating practical filters. Progress in most areas requires neither precise definitions nor consensus. They're nice & often help but 'essential' is a strong word"  
[X Link](https://x.com/KarlPfleger/status/1864792615159501065)  2024-12-05T22:03Z [----] followers, [----] engagements


"Consensus definitions are not typically 'essential' to progress in most science technology & engineering fields. Why should aging be any different @biogerontology @gladyshev_lab Surprises me so many (n=57) agree a consensus def of aging is essential. Do they think AI field achieved consensus def of intelligence before its huge gains It didn't. No consensus porn def either. Famously only know-it-when-you-see-it. Didn't stop creating practical filters. https://t.co/IBoUc30Z1K @biogerontology @gladyshev_lab Surprises me so many (n=57) agree a consensus def of aging is essential. Do they think AI"  
[X Link](https://x.com/KarlPfleger/status/1864819722140991756)  2024-12-05T23:50Z [----] followers, [----] engagements


"Aging is by far the leading cause of death but of non-age-related causes auto accidents are one of the top killers. Autonomous vehicles will change that. 10x safer than humans (90% reduction in bodily injury). Our mission is to be the world's most trusted driver and a new study by @SwissRe validates the exceptional safety record of the Waymo Driver. Learn more: https://t.co/aMTGDZqmtY https://t.co/NKRp93JeSv Our mission is to be the world's most trusted driver and a new study by @SwissRe validates the exceptional safety record of the Waymo Driver. Learn more: https://t.co/aMTGDZqmtY"  
[X Link](https://x.com/KarlPfleger/status/1870140757514039531)  2024-12-20T16:14Z [----] followers, [----] engagements


"@bryan_johnson My cult is same as yours plus investing in the companies making next-gen therapies better than just what you're currently doing. You should join me in doing that too. It's actually the most important piece"  
[X Link](https://x.com/KarlPfleger/status/1887230068076012029)  2025-02-05T20:01Z [----] followers, [----] engagements


"It's [----] & I'm getting excited & even optimistic for the next [--] years in the aging/longevity sector based on looking around at what's going on. It's not that the ultimate solutions will emerge that quickly but the seeds of huge change may be upon the world soon"  
[X Link](https://x.com/KarlPfleger/status/1887932058900828635)  2025-02-07T18:30Z [----] followers, [----] engagements


"An important longevity development is too-little discussed in the field for years: Despite many A trial failures (& little benefit of the few successes) there's another misfolded protein possibly as important in aging with much success: ATTR now has [--] FDA approved therapies"  
[X Link](https://x.com/KarlPfleger/status/1889001506512490500)  2025-02-10T17:20Z [----] followers, 11K engagements


"High vs low protein intake for long-term health & longevity remains controversial even among experts. Recs range from =0.8-2.2g/kg 10-30+% cals f/ protein. Here's a quick collection of refs thoughts & summaries synthesizing many prior conversations & lines of research"  
[X Link](https://x.com/KarlPfleger/status/1889439112823988342)  2025-02-11T22:19Z [----] followers, 26.1K engagements


"It's great that someone high up in politics gets it now. Kudos to Newt. We need people high up in all parties (esp in US but also other countries) to understand the importance of the aging/longevity field & to spread the message to everyone in government. I support @theA4LI Translating aging biology science into treatments would help transform our reactive single-disease focused model of health care to one focused on the prevention of diseases and the optimization of health. @theA4LI @dullunlivin https://t.co/cFldl6xknd Translating aging biology science into treatments would help transform"  
[X Link](https://x.com/KarlPfleger/status/1889723537046352101)  2025-02-12T17:09Z [----] followers, [----] engagements


"@DrSamuelBHume Now stratify by dose BMI baseline 25OHD whether study titrated dose to achieve 25OHD20ng/ml or ideally 30ng & whether outcomes only recorded after enough time for dose to achieve sufficiency. Meta-analyses of flawed studies give flawed answers. See https://x.com/KarlPfleger/status/1732514710715514883 Data from the new TargetD trial suggests that prior vitamin D trials were flawed: https://t.co/SVQVinhC40 Many people even professionals still think vitamin D was a false profit that was disproven by big RCTs. This view is very flawed for several reasons. A brief history:"  
[X Link](https://x.com/KarlPfleger/status/1895234000027074632)  2025-02-27T22:06Z [----] followers, 13.7K engagements


"China's recent biotech success demonstrates the importance of regulatory reforms of clinical trials & the overall speed of the trials. "In recent months Chinas progress in AI has stunned the world. A quieter yet equally significant shift is under way in biotech""  
[X Link](https://x.com/KarlPfleger/status/1896336281275363716)  2025-03-02T23:06Z [----] followers, [----] engagements


"A 2nd important recent longevity development that is too-little discussed in the field: The first [--] FDA approved allogeneic stem cell therapies both in past [--] years. - off-the-shelf - mass-producible - likely relevant for multiple age-related pathologies This is important"  
[X Link](https://x.com/KarlPfleger/status/1897003655137734963)  2025-03-04T19:18Z [----] followers, 16.5K engagements


"Why isn't thymus disease a valid indication for clinical trials Thymic involution significantly degrades immune function increases risk of multiple diseases & increases mortality. It involves fat accumulation & shrinking. Both also happen to the liver"  
[X Link](https://x.com/KarlPfleger/status/1898159647863062938)  2025-03-07T23:51Z [----] followers, [----] engagements


"I made a list of suggestions on how to minimize microplastics & nanoplastics (MNPs) for health. Open to anyone for commenting to help crowdsource improve it. The focus is personal health not environment (which would be a bigger list). Hope it helps. https://docs.google.com/spreadsheets/d/1OG-NJZZ4I587LxP4kvp0WhAUIWGC-yR6Ets0Flr7P5M/editusp=sharing https://docs.google.com/spreadsheets/d/1OG-NJZZ4I587LxP4kvp0WhAUIWGC-yR6Ets0Flr7P5M/editusp=sharing"  
[X Link](https://x.com/KarlPfleger/status/1899863502225092795)  2025-03-12T16:42Z [----] followers, [----] engagements


"The "geroscience hypothesis": Why is the word hypothesis still needed Ample science proves: [--]. Core aging molecular processes play a causal role in age-related diseases [--]. Treating these processes delays many age-related diseases & extends lifespan Why is hypothesis needed"  
[X Link](https://x.com/KarlPfleger/status/1900287372832735629)  2025-03-13T20:46Z [----] followers, [----] engagements


"The Economist this week has [--] articles on human enhancement inc longevity. It's even the cover story. Good But longevity islumped in w/ sport & cognitive enhancement & BCI. The label superhuman is used. So not the focus piece on aging's horrors the field deserves. Details:"  
[X Link](https://x.com/KarlPfleger/status/1903624103300563226)  2025-03-23T01:45Z [----] followers, 11.6K engagements


"Replacement vs repair as alternative strategies for fixing things only differ at the top level of granularity ie wrt replacing the whole vs fixing it. Part-whole granularity is key here. Eg repairing a car may involve replacing the engine or transmission but repairing the engine or transmission may involve replacing a subcomponent of those eg spark plugs or clutch. etc. down to repairing some small piece may involve replacing eg a screw In biological or clinical medical replacement vs repair we can discuss replacing a whole body (head/brain transplant) an organ some tissue cells organelles or"  
[X Link](https://x.com/KarlPfleger/status/1921961547011895707)  2025-05-12T16:11Z [----] followers, [----] engagements


"One of the most exciting thing happening in the aging/longevity field that too few people discuss is that the aggregate pipeline of the entire sector has hit the exciting point where things are trickling thru to FDA approval & many more are on the way. My talk recently posted"  
[X Link](https://x.com/KarlPfleger/status/1922658357481005230)  2025-05-14T14:20Z [----] followers, 14.7K engagements


"Why am I the one to surface this narrative Seems like a bug in the structure/organization of the field as a whole. Perhaps understandable since the aging/longevity subsector of biotech and the broader aging/longevity field isn't a top-down-organization that someone thought carefully about structuring in an organized way. It grew mostly organically. The primary news outlets covering the field @LongevityTech @LifespanIO's News & all cover pieces but usually in articles about a single company at a time occasionally about broader trends or with industry reports but usually those are focused on"  
[X Link](https://x.com/KarlPfleger/status/1929563640807764236)  2025-06-02T15:39Z [----] followers, [----] engagements


"Much focus on muscle & sarcopenia/frailty in aging. Not enough on cartilage+bone & osteoarthritis. Huge $ for muscle therapy R&D. Much less for OA. Good ways to track aging muscle loss across body. Not to track aging cartilage/bone/OA progression. This seems backwards: 🧵"  
[X Link](https://x.com/KarlPfleger/status/1932143796063797348)  2025-06-09T18:32Z [----] followers, [----] engagements


"I love Shift's platform & am a happy investor but finding a single factor isn't novel. @JanineSengstack's [----] preprint identified [--] single rejuv TFs. What's cool in Shift's new result is [--]. works in [--] cell types [--]. it's a gene not just TF [--]. more thorough rejuv demonstration (clock reversal) I think prospects for Shift & for Junevity the company Janine started based on her work (which was her UCSF PhD) are both great. https://www.biorxiv.org/content/10.1101/2022.11.20.517270v2 https://www.biorxiv.org/content/10.1101/2022.11.20.517270v2"  
[X Link](https://x.com/KarlPfleger/status/1932599558657487216)  2025-06-11T00:43Z [----] followers, 82.9K engagements


"LEV isn't a thing with a fixed year of arrival for all. People have to stop talking about it like that whether expressing the optimistic or pessimistic view. As more technologies to reverse diff aspects of the molecular aging process become avail gradually over many years later birth cohorts (people who are younger at the time) will benefit more than those who are older (later birth cohorts). It only makes sense to discuss what birth cohorts will make it to LEV not what year LEV "arrives""  
[X Link](https://x.com/KarlPfleger/status/1935177182328103144)  2025-06-18T03:26Z [----] followers, [----] engagements


"I strongly disagree with your last sentence & last [--] paragraphs taken literally. I wonder if we are using terms differently. There are [--] diff levels here: how much understanding is needed to fully cure aging vs how much is needed to start making good progress on things that treat important aspects of aging & that will likely be necessary components of a full solution. I claim no fundamental new understanding needed for the latter but I agree better understanding would help & is maybe needed to get to LEV eventually. But it seems to me clearly wrong to say some big new understanding is needed"  
[X Link](https://x.com/KarlPfleger/status/1936830015909568762)  2025-06-22T16:53Z [----] followers, [----] engagements


"Some smart knowledgeable people in the aging field (eg @jpsenescence @gladyshev_lab) have said fundamentally deeper understanding of aging is needed to make big progress. I & others (esp @aubreydegrey) disagree. Eg see https://x.com/KarlPfleger/status/1936830015909568762 @jpsenescence @MicahZoltu I strongly disagree with your last sentence & last [--] paragraphs taken literally. I wonder if we are using terms differently. There are [--] diff levels here: how much understanding is needed to fully cure aging vs how much is needed to start making good progress on things that treat"  
[X Link](https://x.com/KarlPfleger/status/1937216226360733954)  2025-06-23T18:28Z [----] followers, [----] engagements


"This is big: Aktiia (now renamed Hilo) gets FDA clearance for first (in US) cuffless continuous blood pressure (BP) monitoring. Product rollout expected in [----]. I'm excited for this. I've been waiting for it for some time. I think it's even more important than CGM"  
[X Link](https://x.com/KarlPfleger/status/1943104937078198624)  2025-07-10T00:28Z [----] followers, [----] engagements


"@DrGlorioso 25mo median ctrl lifespan doesn't come close to the Kennedy/Kaeberlein 900day rule & they didn't even go until 50% of treatment died. 28mo lifespan for treated is unimpressive so really bad they stopped there. Not really impressive life extension data. https://www.sciencedirect.com/science/article/abs/pii/S1568163724003301 https://www.sciencedirect.com/science/article/abs/pii/S1568163724003301"  
[X Link](https://x.com/KarlPfleger/status/1943338755773075800)  2025-07-10T15:57Z [----] followers, [---] engagements


"@rand_longevity @michaelrossen Reversing aging in multiple cells is not what people mostly think "Aging will be reversible in humans" means. Your 1st post in thread is sensationalisticly misleading. People mostly think that means systemic full reversal by equiv of at min several yrs. Not gonna happen quickly"  
[X Link](https://x.com/KarlPfleger/status/1949633542906163698)  2025-07-28T00:50Z [----] followers, [----] engagements


"A post started w/ misleading sensationalism (my reply: amplified w/ more misleading semantics. Epigenetic reprogramming is one of the most exciting areas of the aging field but calling its trials "human age reversal trials" is very misleading. This is not what the avg reader will interpret that phrase to mean. The Sinclair lab's results w/ optic nerve regeneration are great & Life Bio's preclinical data sounds good too but these are not systemic human age reversal in the way most people are probably interpreting you here. (1/2) https://x.com/KarlPfleger/status/1949633542906163698"  
[X Link](https://x.com/KarlPfleger/status/1949636212937113980)  2025-07-28T01:01Z [----] followers, [----] engagements


"All the talk of semaglutide (ozempic) slowing or reversing aging is too exaggerated for the tiny bit of only mildly interesting data reported in a recent preprint. Quick points to keep in mind:"  
[X Link](https://x.com/KarlPfleger/status/1952754912150135118)  2025-08-05T15:33Z [----] followers, [----] engagements


"@jpsenescence To find relevant biotechs: go to click on any cell do browser find-in-page for 'HSC' then do find-in-page for 'thym' HSCs: Retro ImmuneAGE Mogling thymus: LyGenisis FibroBiologics Thymmune Tx Intervene Immune Tolerance Bio Videregen Thymofox http://AgingBiotech.info/companies http://AgingBiotech.info/companies"  
[X Link](https://x.com/KarlPfleger/status/1997330201311867201)  2025-12-06T15:40Z [----] followers, [----] engagements


"@jpsenescence Possibly there are some others that these strings don't catch like maybe HCW Biologics. You can search also for 'immun' but this also pulls in a lot of other things that prob don't qualify for what the original question sought"  
[X Link](https://x.com/KarlPfleger/status/1997380525229486235)  2025-12-06T19:00Z [----] followers, [---] engagements


"@_selfhealthcare @ChrisVMDHealth @rand_longevity @bryan_johnson Slowing aging by 5% or maybe 10-15% is easy. Maybe 20-25% w/ big effort. Slowing by 50% not even achieved for mice or any vertebrate. Most experts agree age-slowing effect sizes will be (much) smaller in humans. This is not the path to 150yr lifespans or curing aging pathology"  
[X Link](https://x.com/KarlPfleger/status/2013745437895991733)  2026-01-20T22:48Z [----] followers, [--] engagements


"I've been thinking this way for a while. It's why my site is called not anything with 'longevity'. I posted related thoughts on this pref from a slightly different angle on LinkedIn (but evidently not on X) about a year ago here: https://www.linkedin.com/posts/karl-r-pfleger_perspective-on-the-aging-field-much-focus-activity-7188526689235173376-Meqk http://AgingBiotech.info https://www.linkedin.com/posts/karl-r-pfleger_perspective-on-the-aging-field-much-focus-activity-7188526689235173376-Meqk http://AgingBiotech.info"  
[X Link](https://x.com/KarlPfleger/status/2016197352605024607)  2026-01-27T17:11Z [----] followers, [--] engagements


"I'm not the only one though. I recently saw a nice discussion w/ similar thoughts by Colin Farrelly in (page [--] shown here). I don't know if others thought the same when choosing titles w/ aging not longevity (Ending Aging FightAging Ageless). https://pmc.ncbi.nlm.nih.gov/articles/PMC9644010/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9644010/"  
[X Link](https://x.com/KarlPfleger/status/2016197457651368072)  2026-01-27T17:11Z [----] followers, [---] engagements


"@MaxUnfried Yes and once we have therapies that can do that we won't need 10+ year clinical trials to show it. Though it will probably take a combination of many therapies to do it reasonably comprehensively"  
[X Link](https://x.com/KarlPfleger/status/2019219582863700101)  2026-02-05T01:20Z [----] followers, [---] engagements


"@davidasinclair You can't avoid damage. Cells will turn senescent & accumulate. Proteins will misfold & agglomerate. Crosslinks will form. Toxic molecules will form. Etc. These are unavoidable consequences of normal living & metabolism. These things must be repaired after the fact"  
[X Link](https://x.com/KarlPfleger/status/2019461901407961218)  2026-02-05T17:23Z [----] followers, [---] engagements


"@MasalaFry69 @SammyRArmstrong Lame ad hominem attack (without even a clear claim of why). Do you also dismiss Luigi Fontana Longo & Fontana are likely the [--] most respected experts in the world at the intersection of the fields of diet/nutrition & aging/longevity. https://x.com/LuigiFontanaMD/status/2017727635493949862 Rethinking frailty muscle and protein through the lens of aging biology The dominant narrative around aging and frailty is deceptively simple and wrong: eat more protein + resistance exercise activate mTOR build more muscle reduce frailty. https://t.co/C6g6HPgyze"  
[X Link](https://x.com/KarlPfleger/status/2019464917649104928)  2026-02-05T17:35Z [----] followers, [--] engagements

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