[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.] #  @Franca_ole Franca_ole Franca_ole posts on X about $sgmo, $sgmos, target, $4503t the most. They currently have XXX followers and XX posts still getting attention that total XXX engagements in the last XX hours. ### Engagements: XXX [#](/creator/twitter::558784211/interactions)  - X Week XXXXXX -XX% - X Month XXXXXXX +56% - X Months XXXXXXX +19% - X Year XXXXXXX +305% ### Mentions: XX [#](/creator/twitter::558784211/posts_active)  - X Week XX -XX% - X Month XXX +68% - X Months XXX +37% - X Year XXX +331% ### Followers: XXX [#](/creator/twitter::558784211/followers)  - X Week XXX +1% - X Month XXX +4.30% - X Months XXX +30% - X Year XXX +56% ### CreatorRank: XXXXXXXXX [#](/creator/twitter::558784211/influencer_rank)  ### Social Influence **Social category influence** [finance](/list/finance) XXXX% [cryptocurrencies](/list/cryptocurrencies) XXXX% [stocks](/list/stocks) XXXX% [countries](/list/countries) XXXX% **Social topic influence** [$sgmo](/topic/$sgmo) #6, [$sgmos](/topic/$sgmos) #1, [target](/topic/target) 5.88%, [$4503t](/topic/$4503t) 5.88%, [strong](/topic/strong) 2.94%, [$vrtx](/topic/$vrtx) 2.94%, [met](/topic/met) 2.94%, [food](/topic/food) 2.94%, [$aclx](/topic/$aclx) 2.94%, [rates](/topic/rates) XXXX% **Top accounts mentioned or mentioned by** [@reg0sce](/creator/undefined) [@researchitgg](/creator/undefined) [@justin48413386](/creator/undefined) [@yusufhameed](/creator/undefined) [@saltodellupo](/creator/undefined) [@octopusking77](/creator/undefined) [@sandymacrae23](/creator/undefined) [@bduclaux](/creator/undefined) [@gothamgirl_1](/creator/undefined) [@jawnzilla](/creator/undefined) [@auditor112017](/creator/undefined) [@zinselmeyerb](/creator/undefined) [@whitecollar86](/creator/undefined) [@tt_ma93127381](/creator/undefined) [@rjalagam9111](/creator/undefined) [@kaysaaa81](/creator/undefined) [@analysethat](/creator/undefined) [@behaviorfin](/creator/undefined) [@peter_paone](/creator/undefined) [@erayarc1846032](/creator/undefined) **Top assets mentioned** [Vertex Protocol (VRTX)](/topic/$vrtx) [Arcellx, Inc. Common Stock (ACLX)](/topic/$aclx) [Curate (XCUR)](/topic/$xcur) ### Top Social Posts Top posts by engagements in the last XX hours "$SGMO Sangamo Therapeutics Receives U.S. FDA Fast Track Designation for ST-503 for the Treatment of Small Fiber Neuropathy Strong Buy" [X Link](https://x.com/Franca_ole/status/1995843580527866098) 2025-12-02T13:12Z XXX followers, 4576 engagements "With good efficacy and high acceptance especially for chronic and neuropathic pain such an active ingredient could become a multi-billion-dollar blockbuster comparable to established painkillers/analgesics perhaps with market shares on a scale that would be attractive to pharmaceutical giants (eg $VRTX)" [X Link](https://x.com/Franca_ole/status/1996175497441464602) 2025-12-03T11:11Z XXX followers, XXX engagements "" $SGMO Therapeutics the therapys developer said it met with the U.S. Food and Drug Administration (FDA) and agreed on a proposed efficacy and safety data package to support an approval pathway for the treatment. The company said it expects to submit an application for accelerated approval as soon as early 2026."" [X Link](https://x.com/Franca_ole/status/1996946511914012732) 2025-12-05T14:15Z XXX followers, 1721 engagements "The CMC (Chemistry Manufacturing and Controls) for a gene therapy such as $SGMO s ST-920 is arguably the most critical part of the BLA. CMC encompasses all documentation and evidence related to how the product and manufacturing process are designedincluding product identity purity potency stability and consistency across different batches. For viral vectors (such as AAV for ST-920) many critical parameters are relevant e.g. the quantity and quality of the viral genomes the ratio of full vs. empty particles residual DNA or residual proteins from the cell culture purity stability sterility" [X Link](https://x.com/Franca_ole/status/1997619608807764411) 2025-12-07T10:50Z XXX followers, 2490 engagements "This $SGMO editing system is potentially less immunogenic than CRISPR because CRISPR systems originate from bacteria which are foreign proteins in humans and are often identified as invaders by the immune system. Zinc finger proteins on the other hand resemble natural human proteins (they occur regularly in the human genome) and therefore tend to cause fewer immune reactions. That's a major advantage" [X Link](https://x.com/Franca_ole/status/1993988612183011614) 2025-11-27T10:21Z XXX followers, 1293 engagements "$ACLX reported a XX% ORR and XX% CR/sCR with anito-cel in pivotal ph2 iMMagine-1 for relapsed/refrac MM with deep and durable responses XX% MRD negativity and 24m PFS and OS rates of XX% and 83%. BLA submission based on October 2025 cutoff" [X Link](https://x.com/Franca_ole/status/1998123213973307750) 2025-12-08T20:11Z XXX followers, XXX engagements "$SGMO has its own cGMP manufacturing facility in Brisbane California (USA). In addition Sangamo has access to capacity at Brammer Bio (now part of Thermo Fisher) particularly for large-scale AAV manufacturing (up to 2000-liter bioreactors). The contract with Brammer Bio covers bioreactors with volumes of up to 2000 liters suitable for commercial production of ST-920 (source: 10K from 2020). Activities in Valbonne (France) have been discontinued. With its combination of in-house manufacturing and external CMO Sangamo appears well equipped to meet a very large portion of the global demand for" [X Link](https://x.com/Franca_ole/status/1991486307667685387) 2025-11-20T12:38Z XXX followers, 2476 engagements "Just bought 120000 $SGMO shares for = $0.42" [X Link](https://x.com/Franca_ole/status/1993353576198914501) 2025-11-25T16:18Z XXX followers, 3666 engagements "$SGMO's latest patent application US 20250361528 A1 describes a new type of base editorgenetic engineering tools that can target and modify individual DNA bases. The inventors are developing fusion proteins that combine two functional units namely zinc finger domains (zinc finger proteins) and cytidine deaminases i.e. enzymes that convert cytosine (C) into uracil (U) resulting in a targeted CT mutation in the genome. Among other things the patent claims novel combinations of zinc fingers + deaminase specific designs that improve accuracy and efficiency and applications in which individual" [X Link](https://x.com/Franca_ole/status/1993984316620067150) 2025-11-27T10:04Z XXX followers, 9335 engagements "$SGMO #ST503 Fast Track designation is an FDA program designed to accelerate the development and review of new drugs (or gene therapies etc.) intended for serious diseases and where there is a high medical need particularly when there are few or no good existing treatments. Fast Track allows a company to have more frequent and earlier communication with the FDA which can clarify questions or issues more quickly and thus make the development process more efficient. In addition under certain conditionsif the clinical trial is successfulfaster approval procedures are possible such as Accelerated" [X Link](https://x.com/Franca_ole/status/1995848162452386165) 2025-12-02T13:30Z XXX followers, 2219 engagements ""The most common adverse events reported during STAAR were fever COVID-19 the common cold and headache all of which were resolved with standard medical treatments."" [X Link](https://x.com/Franca_ole/status/1996696598714142974) 2025-12-04T21:42Z XXX followers, XXX engagements "When announcing the quarterly results Astellas management explicitly makes the following statement in the Q&A: In principle there is no change. Gene therapy is one of the important Primary Focus areas for us" [X Link](https://x.com/Franca_ole/status/1983939558719754726) 2025-10-30T16:50Z XXX followers, 4791 engagements "Astellas is looking for a Scientist Gene Regulation Technology" [X Link](https://x.com/Franca_ole/status/1982861791270187452) 2025-10-27T17:27Z XXX followers, 3559 engagements "I wouldn't have thought that prominent analysts would be so unfamiliar with FDA regulations $SGMO" [X Link](https://x.com/Franca_ole/status/1991947937983656013) 2025-11-21T19:12Z XXX followers, 3583 engagements "@Justin48413386 @yusufhameed @sandymacrae23 If no company is willing to even come close to recognizing the value of ST-920 then it would be better for $SGMO to bring this gene therapy to market on its own. Fabry seems to be a suitable candidate for this because demand can be met with just a few centers" [X Link](https://x.com/Franca_ole/status/1995957530368119150) 2025-12-02T20:45Z XXX followers, 1333 engagements "The MINT platform from $SGMO (Modular INTegrase) is a very exciting new technology for genome editing. MINT is designed to enable the targeted insertion of large DNA sequences (e.g. complete genes) into the genome. This is particularly important because many genetic diseases are caused by missing or defective genes. With MINT such genes could be completely integrated into the correct genome locus rather than just making small corrections. Traditional gene editing methods (e.g. CRISPR) often create double-strand breaks in the DNA which can be potentially risky (e.g. translocations or unwanted" [X Link](https://x.com/Franca_ole/status/1993074084096201136) 2025-11-24T21:47Z XXX followers, 3127 engagements ""One-time infusion with $SGMO ST-920 improved kidney function and stabilized heart function in people with Fabry disease trial data showed." The Fabry community is being informed about ST-920 through various patient organizations. This is beneficial for both those affected and the company" [X Link](https://x.com/Franca_ole/status/1996695852371661003) 2025-12-04T21:39Z XXX followers, 2708 engagements "$SGMO said it expects to submit an application for accelerated approval as soon as early 2026" [X Link](https://x.com/Franca_ole/status/1996697091335184495) 2025-12-04T21:44Z XXX followers, 1332 engagements "$XCUR reported ph2 results for burixafor plus propranolol and G-CSF in multiple myeloma patients undergoing autologous transplant with XXXX% achieving the primary endpoint of adequate CD34+ cell mobilization in X sessions" [X Link](https://x.com/Franca_ole/status/1998413495176511606) 2025-12-09T15:24Z XXX followers, XXX engagements
[GUEST ACCESS MODE: Data is scrambled or limited to provide examples. Make requests using your API key to unlock full data. Check https://lunarcrush.ai/auth for authentication information.]
@Franca_ole Franca_ole
Franca_ole posts on X about $sgmo, $sgmos, target, $4503t the most. They currently have XXX followers and XX posts still getting attention that total XXX engagements in the last XX hours.
Engagements: XXX #
- X Week XXXXXX -XX%
- X Month XXXXXXX +56%
- X Months XXXXXXX +19%
- X Year XXXXXXX +305%
Mentions: XX #
- X Week XX -XX%
- X Month XXX +68%
- X Months XXX +37%
- X Year XXX +331%
Followers: XXX #
- X Week XXX +1%
- X Month XXX +4.30%
- X Months XXX +30%
- X Year XXX +56%
CreatorRank: XXXXXXXXX #
Social Influence
Social category influence finance XXXX% cryptocurrencies XXXX% stocks XXXX% countries XXXX%
Social topic influence $sgmo #6, $sgmos #1, target 5.88%, $4503t 5.88%, strong 2.94%, $vrtx 2.94%, met 2.94%, food 2.94%, $aclx 2.94%, rates XXXX%
Top accounts mentioned or mentioned by @reg0sce @researchitgg @justin48413386 @yusufhameed @saltodellupo @octopusking77 @sandymacrae23 @bduclaux @gothamgirl_1 @jawnzilla @auditor112017 @zinselmeyerb @whitecollar86 @tt_ma93127381 @rjalagam9111 @kaysaaa81 @analysethat @behaviorfin @peter_paone @erayarc1846032
Top assets mentioned Vertex Protocol (VRTX) Arcellx, Inc. Common Stock (ACLX) Curate (XCUR)
Top Social Posts
Top posts by engagements in the last XX hours
"$SGMO Sangamo Therapeutics Receives U.S. FDA Fast Track Designation for ST-503 for the Treatment of Small Fiber Neuropathy Strong Buy"
X Link 2025-12-02T13:12Z XXX followers, 4576 engagements
"With good efficacy and high acceptance especially for chronic and neuropathic pain such an active ingredient could become a multi-billion-dollar blockbuster comparable to established painkillers/analgesics perhaps with market shares on a scale that would be attractive to pharmaceutical giants (eg $VRTX)"
X Link 2025-12-03T11:11Z XXX followers, XXX engagements
"" $SGMO Therapeutics the therapys developer said it met with the U.S. Food and Drug Administration (FDA) and agreed on a proposed efficacy and safety data package to support an approval pathway for the treatment. The company said it expects to submit an application for accelerated approval as soon as early 2026.""
X Link 2025-12-05T14:15Z XXX followers, 1721 engagements
"The CMC (Chemistry Manufacturing and Controls) for a gene therapy such as $SGMO s ST-920 is arguably the most critical part of the BLA. CMC encompasses all documentation and evidence related to how the product and manufacturing process are designedincluding product identity purity potency stability and consistency across different batches. For viral vectors (such as AAV for ST-920) many critical parameters are relevant e.g. the quantity and quality of the viral genomes the ratio of full vs. empty particles residual DNA or residual proteins from the cell culture purity stability sterility"
X Link 2025-12-07T10:50Z XXX followers, 2490 engagements
"This $SGMO editing system is potentially less immunogenic than CRISPR because CRISPR systems originate from bacteria which are foreign proteins in humans and are often identified as invaders by the immune system. Zinc finger proteins on the other hand resemble natural human proteins (they occur regularly in the human genome) and therefore tend to cause fewer immune reactions. That's a major advantage"
X Link 2025-11-27T10:21Z XXX followers, 1293 engagements
"$ACLX reported a XX% ORR and XX% CR/sCR with anito-cel in pivotal ph2 iMMagine-1 for relapsed/refrac MM with deep and durable responses XX% MRD negativity and 24m PFS and OS rates of XX% and 83%. BLA submission based on October 2025 cutoff"
X Link 2025-12-08T20:11Z XXX followers, XXX engagements
"$SGMO has its own cGMP manufacturing facility in Brisbane California (USA). In addition Sangamo has access to capacity at Brammer Bio (now part of Thermo Fisher) particularly for large-scale AAV manufacturing (up to 2000-liter bioreactors). The contract with Brammer Bio covers bioreactors with volumes of up to 2000 liters suitable for commercial production of ST-920 (source: 10K from 2020). Activities in Valbonne (France) have been discontinued. With its combination of in-house manufacturing and external CMO Sangamo appears well equipped to meet a very large portion of the global demand for"
X Link 2025-11-20T12:38Z XXX followers, 2476 engagements
"Just bought 120000 $SGMO shares for = $0.42"
X Link 2025-11-25T16:18Z XXX followers, 3666 engagements
"$SGMO's latest patent application US 20250361528 A1 describes a new type of base editorgenetic engineering tools that can target and modify individual DNA bases. The inventors are developing fusion proteins that combine two functional units namely zinc finger domains (zinc finger proteins) and cytidine deaminases i.e. enzymes that convert cytosine (C) into uracil (U) resulting in a targeted CT mutation in the genome. Among other things the patent claims novel combinations of zinc fingers + deaminase specific designs that improve accuracy and efficiency and applications in which individual"
X Link 2025-11-27T10:04Z XXX followers, 9335 engagements
"$SGMO #ST503 Fast Track designation is an FDA program designed to accelerate the development and review of new drugs (or gene therapies etc.) intended for serious diseases and where there is a high medical need particularly when there are few or no good existing treatments. Fast Track allows a company to have more frequent and earlier communication with the FDA which can clarify questions or issues more quickly and thus make the development process more efficient. In addition under certain conditionsif the clinical trial is successfulfaster approval procedures are possible such as Accelerated"
X Link 2025-12-02T13:30Z XXX followers, 2219 engagements
""The most common adverse events reported during STAAR were fever COVID-19 the common cold and headache all of which were resolved with standard medical treatments.""
X Link 2025-12-04T21:42Z XXX followers, XXX engagements
"When announcing the quarterly results Astellas management explicitly makes the following statement in the Q&A: In principle there is no change. Gene therapy is one of the important Primary Focus areas for us"
X Link 2025-10-30T16:50Z XXX followers, 4791 engagements
"Astellas is looking for a Scientist Gene Regulation Technology"
X Link 2025-10-27T17:27Z XXX followers, 3559 engagements
"I wouldn't have thought that prominent analysts would be so unfamiliar with FDA regulations $SGMO"
X Link 2025-11-21T19:12Z XXX followers, 3583 engagements
"@Justin48413386 @yusufhameed @sandymacrae23 If no company is willing to even come close to recognizing the value of ST-920 then it would be better for $SGMO to bring this gene therapy to market on its own. Fabry seems to be a suitable candidate for this because demand can be met with just a few centers"
X Link 2025-12-02T20:45Z XXX followers, 1333 engagements
"The MINT platform from $SGMO (Modular INTegrase) is a very exciting new technology for genome editing. MINT is designed to enable the targeted insertion of large DNA sequences (e.g. complete genes) into the genome. This is particularly important because many genetic diseases are caused by missing or defective genes. With MINT such genes could be completely integrated into the correct genome locus rather than just making small corrections. Traditional gene editing methods (e.g. CRISPR) often create double-strand breaks in the DNA which can be potentially risky (e.g. translocations or unwanted"
X Link 2025-11-24T21:47Z XXX followers, 3127 engagements
""One-time infusion with $SGMO ST-920 improved kidney function and stabilized heart function in people with Fabry disease trial data showed." The Fabry community is being informed about ST-920 through various patient organizations. This is beneficial for both those affected and the company"
X Link 2025-12-04T21:39Z XXX followers, 2708 engagements
"$SGMO said it expects to submit an application for accelerated approval as soon as early 2026"
X Link 2025-12-04T21:44Z XXX followers, 1332 engagements
"$XCUR reported ph2 results for burixafor plus propranolol and G-CSF in multiple myeloma patients undergoing autologous transplant with XXXX% achieving the primary endpoint of adequate CD34+ cell mobilization in X sessions"
X Link 2025-12-09T15:24Z XXX followers, XXX engagements