# ![@DoctorOmene Avatar](https://lunarcrush.com/gi/w:26/cr:twitter::1914082077240107009.png) @DoctorOmene Dr. Omene

Dr. Omene posts on X about if you, real world, llm, threshold the most. They currently have [--] followers and [--] posts still getting attention that total [-----] engagements in the last [--] hours.

### Engagements: [-----] [#](/creator/twitter::1914082077240107009/interactions)
![Engagements Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1914082077240107009/c:line/m:interactions.svg)

- [--] Week [------] +40,775%

### Mentions: [--] [#](/creator/twitter::1914082077240107009/posts_active)
![Mentions Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1914082077240107009/c:line/m:posts_active.svg)


### Followers: [--] [#](/creator/twitter::1914082077240107009/followers)
![Followers Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1914082077240107009/c:line/m:followers.svg)

- [--] Week [--] +130%

### CreatorRank: [-------] [#](/creator/twitter::1914082077240107009/influencer_rank)
![CreatorRank Line Chart](https://lunarcrush.com/gi/w:600/cr:twitter::1914082077240107009/c:line/m:influencer_rank.svg)

### Social Influence

**Social category influence**
[finance](/list/finance)  7.5%

**Social topic influence**
[if you](/topic/if-you) 7.5%, [real world](/topic/real-world) #1120, [llm](/topic/llm) 7.5%, [threshold](/topic/threshold) 7.5%, [events](/topic/events) 5%, [this is](/topic/this-is) 5%, [compound](/topic/compound) 2.5%, [a pro](/topic/a-pro) 2.5%, [eat](/topic/eat) 2.5%, [salt](/topic/salt) 2.5%

**Top accounts mentioned or mentioned by**
[@grok](/creator/undefined) [@nntaleb](/creator/undefined) [@makismedicine](/creator/undefined) [@legendgonna](/creator/undefined) [@probnstat](/creator/undefined) [@biorxivimmuno](/creator/undefined) [@oncbrothers](/creator/undefined) [@renohemonc](/creator/undefined) [@bijoytelivala](/creator/undefined) [@dryakupergun](/creator/undefined) [@leni23934496](/creator/undefined) [@yoshiv1](/creator/undefined) [@shrutipatelmd](/creator/undefined) [@centralparkwmd](/creator/undefined) [@jason](/creator/undefined) [@tunguz](/creator/undefined) [@slavovn](/creator/undefined) [@chamberoffit](/creator/undefined) [@drpatrick](/creator/undefined) [@oncupdates](/creator/undefined)
### Top Social Posts
Top posts by engagements in the last [--] hours

"@nntaleb Use machines bro - much safer. Unless you are trying to be a pro compound lifts don't make sense. They are not "ecological". If you want randomness for motor system then rock climb"  
[X Link](https://x.com/DoctorOmene/status/2022740840549093608)  2026-02-14T18:32Z [--] followers, [----] engagements


"LMNT and electrolytes don't make a ton of sense unless you are a shareholder. Just read the label and think about how much electrolytes you are getting. You could just eat plants and use some salt in your food for the same result. I think it's mostly taste and placebo in those packages. https://twitter.com/i/web/status/2022743427356725440 https://twitter.com/i/web/status/2022743427356725440"  
[X Link](https://x.com/DoctorOmene/status/2022743427356725440)  2026-02-14T18:43Z [--] followers, [----] engagements


"@Jason @grok discuss why Apple Silicon is a gamechanger for AI space"  
[X Link](https://x.com/DoctorOmene/status/2022781490271043720)  2026-02-14T21:14Z [--] followers, [----] engagements


"@MakisMedicine It would be cutting edge if you did a standard retrospective analysis if your [----] cases. You could control for variables including the effect of standard of care"  
[X Link](https://x.com/DoctorOmene/status/2022815759437639935)  2026-02-14T23:30Z [--] followers, [----] engagements


"@tunguz It's pretty wild that so much talent concentrates there but the metric of success is peer reviewed publication. not making things in the real world"  
[X Link](https://x.com/DoctorOmene/status/2023121885714599987)  2026-02-15T19:46Z [--] followers, [---] engagements


"@slavov_n Big data but no idea. Cancer biology is like this. Lists of mutations that simultaneously serve as oncogenes in one context but tumor suppressors in another"  
[X Link](https://x.com/DoctorOmene/status/2020121349495136543)  2026-02-07T13:03Z [--] followers, [--] engagements


"@ChamberofFit Incremental sustained progressive overload with resistance training meet incremental sustained calorie deficit 🫱🏻🫲🏾. Need to thread the needle with protein intake though"  
[X Link](https://x.com/DoctorOmene/status/2020969204120420381)  2026-02-09T21:13Z [--] followers, [---] engagements


"@probnstat @grok Do they use Bayesian inference"  
[X Link](https://x.com/DoctorOmene/status/2020984262514835867)  2026-02-09T22:12Z [--] followers, [----] engagements


"@grok @biorxiv_immuno Is this M1 or M2"  
[X Link](https://x.com/DoctorOmene/status/2021010241572438055)  2026-02-09T23:56Z [--] followers, [--] engagements


"@grok @probnstat But in ML and LLM statistical machinery the point estimate is NOT discarded similarly - is that correct"  
[X Link](https://x.com/DoctorOmene/status/2021018393579819044)  2026-02-10T00:28Z [--] followers, [--] engagements


"@OncBrothers @RenoHemonc @DrPatrick @OncUpdates @RoswellPark @WilmotCancer @BijoyTelivala @dr_yakupergun @alshamsi2000 @JoshMeeks @UroCancerMD @RKSayyid @lungoncdoc The whole "but what about lymphopenia" angle makes you raise an eyebrow. Lymphopenia has been on everyone's radar since time immemorial. I do hope NK therapies take off though"  
[X Link](https://x.com/DoctorOmene/status/2021265685481963549)  2026-02-10T16:51Z [--] followers, [---] engagements


"@ElieJarrougeMD Lots of real world evidence"  
[X Link](https://x.com/DoctorOmene/status/2021697627599880597)  2026-02-11T21:27Z [--] followers, [---] engagements


"What blood tests do you order to support this claim "It increases T cell function upregulates Toll-like receptor [--] boosts IL-2 and interferon gamma enhances NK cell activity and increases MHC-1 expression." T cell subsets You can just order interleukins and IFN gamma that easy"  
[X Link](https://x.com/DoctorOmene/status/2021718464898249195)  2026-02-11T22:50Z [--] followers, [--] engagements


"@nntaleb Creatine super saturation makes sense. I think there's a big burden of proof on showing harm"  
[X Link](https://x.com/DoctorOmene/status/2021772931198754931)  2026-02-12T02:26Z [--] followers, [----] engagements


"@naval Good taste is the ineffable secret sauce. ✨"  
[X Link](https://x.com/DoctorOmene/status/2021957876882010492)  2026-02-12T14:41Z [--] followers, [--] engagements


"In a human with a fraction of the metabolic rate of a mouse I'm skeptical dunking in cold water for tens of seconds is going to impact any physiologic process for long enough to move the needle. A [--] day fast will for example would have a way more durable impact. And this is partly because of the duration of exposure. https://twitter.com/i/web/status/2022034793198936453 https://twitter.com/i/web/status/2022034793198936453"  
[X Link](https://x.com/DoctorOmene/status/2022034793198936453)  2026-02-12T19:47Z [--] followers, [--] engagements


"@kimianora Cortex is Bayesian 💯. Sensation and perception fix prediction errors"  
[X Link](https://x.com/DoctorOmene/status/2022109306192277899)  2026-02-13T00:43Z [--] followers, [--] engagements


"It's whack a mole. Shotgun "omics" approaches won't solve it. Signal transduction pathways are redundant. No one asks - what is the downstream effect of a specific signal transduction pathway (e.g. EGFR) In most cases it is upregulation of glucose and glutamine metabolism. Redundant signal transduction pathways converge on primary metabolism. Why Because only two pathways support proliferation: glucose and glutamine metabolism. https://twitter.com/i/web/status/2022329804016509163 https://twitter.com/i/web/status/2022329804016509163"  
[X Link](https://x.com/DoctorOmene/status/2022329804016509163)  2026-02-13T15:19Z [--] followers, [---] engagements


"7/What terminal patients need: ✓ Measured efficacy (3 months) ✓ Measured harms (adverse events) ✓ Uncertainty quantified (HR CI LR) ✓ Autonomy (you decide) NOT: ✗ P-value gatekeeping ✗ Arbitrary [----] threshold ✗ "No benefit" declaration even if you measured a real effect https://twitter.com/i/web/status/2022471180138188896 https://twitter.com/i/web/status/2022471180138188896"  
[X Link](https://x.com/DoctorOmene/status/2022471180138188896)  2026-02-14T00:41Z [--] followers, [--] engagements


"@Beechwood_Ben @Leni23934496 @nntaleb If your real world includes trying to stay healthy for as long as possible then you need a decent amount 🙃"  
[X Link](https://x.com/DoctorOmene/status/2022746706975264780)  2026-02-14T18:56Z [--] followers, [--] engagements


"@NicHulscher Deserves a look in clinical trials. Seems metformin tier to me. Biggest lever is inhibiting electron flow through ETC and influencing ADP/ATP ratios"  
[X Link](https://x.com/DoctorOmene/status/2022774175627436141)  2026-02-14T20:45Z [--] followers, [--] engagements


"@IanCopeland5 Actually I think he's on to something"  
[X Link](https://x.com/DoctorOmene/status/2022868702689923529)  2026-02-15T03:00Z [--] followers, [--] engagements


"@yoshi_v1 How does shielded pool increase if overall supply is fixed Is there some sort of baked in protocol mechanism"  
[X Link](https://x.com/DoctorOmene/status/2023096360023794135)  2026-02-15T18:05Z [--] followers, [--] engagements


"@seagertp @grok is there good evidence that cold plunges increase testosterone"  
[X Link](https://x.com/DoctorOmene/status/2022149578074804264)  2026-02-13T03:23Z [--] followers, [--] engagements


"3/Three facts about p-values: They don't address bias (randomization does) They don't measure harm (recorded adverse events do) They ignore prior evidence (decades of understanding discarded) Yet p [----] gates access to measured benefit AND measured harm data"  
[X Link](https://x.com/DoctorOmene/status/2022471174102618267)  2026-02-14T00:41Z [--] followers, [--] engagements


"4/How clinical reasoning actually works: Patient: Smoker + chest pain. Prior probability of serious illness: 60% ECG positive (LR = 8). Post-test probability: 90% confident in diagnosis Decision: Treat now No p-value. No gatekeeping. Uses prior knowledge. This is how doctors think. https://twitter.com/i/web/status/2022471175503544396 https://twitter.com/i/web/status/2022471175503544396"  
[X Link](https://x.com/DoctorOmene/status/2022471175503544396)  2026-02-14T00:41Z [--] followers, [--] engagements


"@BeyondTheMemes I keep wanting I love the dough to hit but it never does. Was there a good Hov collab beyond Brooklyn's Finest"  
[X Link](https://x.com/DoctorOmene/status/2022702883012006149)  2026-02-14T16:02Z [--] followers, [---] engagements


"Imagining a new pillar of cancer treatment- metabolic therapy. Proud of this work @tnseyfried Cancer metabolism is the base layer for everything else and targeting it is key https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4"  
[X Link](https://x.com/DoctorOmene/status/1914109894107553990)  2025-04-21T00:12Z [--] followers, [----] engagements


"@biorxiv_immuno @grok summarize this"  
[X Link](https://x.com/DoctorOmene/status/2021009886101086585)  2026-02-09T23:54Z [--] followers, [--] engagements


"5/Your intervention should follow the same clinical reasoning: Prior probability intervention helps (preclinical mechanism prior studies): 75% New trial data: LR = [----] (benefit slightly favored) Posterior: 85% confident in benefit Decision: Offer intervention patient decides But p-values prevent gatekeep this"  
[X Link](https://x.com/DoctorOmene/status/2022471177143488627)  2026-02-14T00:41Z [--] followers, [--] engagements


"6/The null hypothesis probability before the trial should take into consideration: Preclinical screening: ✓ Proven mechanism: ✓ Prior studies showed benefit: ✓ Biology predicts response: ✓ Probability of zero effect: 2-5% BUT P-values use symmetric threshold. Ignores all prior information. Treats null and benefit as equally plausible. They're not. https://twitter.com/i/web/status/2022471178720546853 https://twitter.com/i/web/status/2022471178720546853"  
[X Link](https://x.com/DoctorOmene/status/2022471178720546853)  2026-02-14T00:41Z [--] followers, [--] engagements


"8/The fix: Apply clinical reasoning (how doctors actually think) Prior 75% + LR [----] Posterior 85% confidence Patient decides No gatekeeping. No arbitrary threshold. Terminal patients deserve measured data and clinical judgment. Not p-value fiction"  
[X Link](https://x.com/DoctorOmene/status/2022471181690114263)  2026-02-14T00:41Z [--] followers, [--] engagements


"Chronic inflammation - a mechanism: #mitochondria Excess calories deliver excess electrons overwhelming mitochondrial electron transport generating ROS/reductive stress and igniting chronic inflammation. It's a beautiful example of how modern abundance (caloric surplus) clashes with ancient cellular machinery designed for scarcity. https://twitter.com/i/web/status/2022701386090102940 https://twitter.com/i/web/status/2022701386090102940"  
[X Link](https://x.com/DoctorOmene/status/2022701386090102940)  2026-02-14T15:56Z [--] followers, [--] engagements


"@MakisMedicine Ya but just do the science. What you have is [----] anecdotes with no controls. I am sure there are at least [---] cases that are unequivocal signal in there if you're on to something. Just publish the slam dunk cases"  
[X Link](https://x.com/DoctorOmene/status/2022831661390467338)  2026-02-15T00:33Z [--] followers, [---] engagements


"Great post. Phase III RCT and meta-analysis is the tip of the evidence based pyramid - it's not the entire pyramid. A bullet-proof phase III RCT is a luxury and can't be expected to answer every question. Biological first principles should be paired with appropriate statistics to help inform clinical reasoning. 🧠📊 Making clinical decisions without randomized trials: how far can we go Randomized controlled trials (RCTs) are the gold standard for causal inferencebut in daily practice clinicians constantly act without them. This sharp invited commentary in JAMA Internal Medicine"  
[X Link](https://x.com/DoctorOmene/status/2023088546282627530)  2026-02-15T17:34Z [--] followers, [--] engagements


"@ShrutiPatelMD @OncBrothers @US_FDA @GIcancerDoc @MPishvaian @rachnatshroff @ShaalanBeg @CentralParkWMD @dr_yakupergun @BijoyTelivala @RenoHemonc @PancSMChat @NiuSanford This is a good point and shows how selection bias can distort the signal in smaller studies. It would be interesting to see the crude patient breakdown and how each sub-group fared in Vit C arm versus historical controls"  
[X Link](https://x.com/DoctorOmene/status/2023094979313176688)  2026-02-15T18:00Z [--] followers, [--] engagements


"@LegendGonna @yoshi_v1 Ok - what does "shielding" mean"  
[X Link](https://x.com/DoctorOmene/status/2023100823426007062)  2026-02-15T18:23Z [--] followers, [--] engagements


"@bryan_johnson "In short a powerful longevity therapy" - where can I pay $1 million for this advice Asking for a friend"  
[X Link](https://x.com/DoctorOmene/status/2023125406669476287)  2026-02-15T20:00Z [--] followers, [---] engagements


"Your friendly neighborhood LLM is a very competent biostatistician. Just ask We did a proof of concept on GBM data. It's easier to just ask an LLM than use SPSS. You can get the standard set of clinical oncology stats and figures just by asking in plain language. @myESMO https://www.esmorwd.org/article/S2949-8201(25)00542-9/fulltext https://www.esmorwd.org/article/S2949-8201(25)00542-9/fulltext https://www.esmorwd.org/article/S2949-8201(25)00542-9/fulltext https://www.esmorwd.org/article/S2949-8201(25)00542-9/fulltext"  
[X Link](https://x.com/DoctorOmene/status/2019156516700381634)  2026-02-04T21:10Z [--] followers, [--] engagements


"@papiwontmiss You are an LLM"  
[X Link](https://x.com/DoctorOmene/status/2020184887064740248)  2026-02-07T17:16Z [--] followers, [--] engagements

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