@trikomes Nick Jikomes

Nick Jikomes posts on X about health, in the, human, science the most. They currently have [------] followers and [---] posts still getting attention that total [------] engagements in the last [--] hours.

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Social Influence

Social category influence countries 7% celebrities 5% finance 3% stocks 3% technology brands 2% products 1% travel destinations 1% cryptocurrencies 1%

Social topic influence health #4074, in the 9%, human #1718, science 4%, wrong #2024, his name #56, gain 4%, if you 3%, food 3%, this is 3%

Top accounts mentioned or mentioned by @anonemus349832 @tuckergoodrich @boudicca0000 @swipewright @mollymoon @pragmaticnurse @lennavelaryon @grifterlouie @michaelbyrne @heidijaneuk @densityinfinite @coachdango @thetinfoilcap @oliverventure @brianmuraresku @dominicdagosti2 @luv2read13 @noetechnesis @mdvilntfluid @hubermanlabs

Top assets mentioned Gigachad (GIGA) Alphabet Inc Class A (GOOGL)

Top Social Posts

Top posts by engagements in the last [--] hours

"🧵Wearing a glucose monitor for a few days to see what kind of responder profile I have. Ill put my first reading here soon and post results in this thread after meals and activities. This is how variable the glycemic response profiles to carb-rich foods of people are: https://t.co/v0JyTbqXY5 This is how variable the glycemic response profiles to carb-rich foods of people are: https://t.co/v0JyTbqXY5"
X Link 2026-02-03T01:09Z 11.2K followers, [----] engagements

"There are two isomers of MDMA ("ecstasy"). In rodents the effects of each isomer differ in terms of there effects on neural plasticity in the cerebral cortex depending on sex (male vs. female). S-MDMA behaves has a weak agonist of the 5-HT2A receptor (the one necessary for the hallucinogenic effects of psychedelics) and elicits the "head-twitch response" in mice which psychedelics like psilocybin and LSD elicit. The effects of S-MDMA on structural plasticity in the cortex depended on sex: dendritic spine density was enhanced in the frontal cortex of males but not females. The effects on the"
X Link 2026-02-03T17:50Z 11.2K followers, [---] engagements

"Even if health experts like Attia and Johnson didnt actually do anything overtly illegal or didnt really know any of the heinous things Epstein was up to beyond what was publicly known What their communications show is that they prioritize their own careers and business interests above truth-seeking. Willing to schmooze and network with anyone as long as it might serve them. Such individuals will sacrifice truth in favor of business if they need to. Of course if the truth happens to align with their business interests they will flaunt it as anyone would. But when its not aligned with their"
X Link 2026-02-04T00:01Z 11.2K followers, 30.8K engagements

"In summary: A bald protein bar salesman who DOES believe otherwise healthy young adults should take statins and who does NOT believe seed oils pose a risk to human health (right) tried and failed to cure the ultra-low testosterone levels of a human trafficker lacking a thymus gland (left) using a low-carb diet. Ladies and gentleman I give you Dr. Peter Attia health expert. 🚨NEW: Epstein's testosterone levels were only [---] ng/dL. The normal range is 250-827 ng/DL. Epstein was genetically a soyboy low T beta male. If he got on some TRT or 10G creatine a day would he have changed his ways or"
X Link 2026-02-04T21:23Z 11.1K followers, 10.5K engagements

"Can correcting a copper deficiency normalize high cholesterol A physician I spoke to described how his cholesterol levels were 250-30 but he nonetheless showed no signs of arterial plaque (CAC scan). He lowered his cholesterol by consuming liver instead of taking statins"
X Link 2026-02-07T03:40Z 11.2K followers, [----] engagements

"Thats basically what this is. If you think about it for a couple seconds youll realize that charts like this arent based on actual intake or verified measurements. Or did you think someone went to each country and carefully measured and verified seed oil intake for a whole bunch of people in each place And ensured the sample populations were representative Itd be sort of like running analysis on data built purely from nutrition facts labels on packaged food and peoples memory of what they ate last week. (Okay grandma tell me how many grams of chips you ate last week.) Come to think of it the"
X Link 2026-02-07T17:58Z 11.2K followers, [----] engagements

"Recently purchased a sleek sexy and expensive MacBook Pro laptop. And the new iOS update has more or less ruined my honeymoon phase with it"
X Link 2026-02-07T18:48Z 11.2K followers, [----] engagements

"Standing in solidarity with those who don't care about football. ✊"
X Link 2026-02-08T21:08Z 11.2K followers, [----] engagements

"David Attenborough voice: As a social primate female Homo sapiens are naturally drawn to infants and hyper-sensitive to social reinforcement by peers. With one touch a newborn can trigger an intense reflexive response sometimes called baby fever. It can be seen even in young females with no prior maternal experience. But competition for the best mates is fierce. To sabotage opponents some females have worked to undermine their rivals by minimizing their exposure to children and glamorizing office work and other childless modes of being. Biologists call this strategy mate suppression and its"
X Link 2026-02-08T22:18Z 11.2K followers, [---] engagements

"New podcast about a mysterious highly interconnected brain region called the claustrum. We cover recent science showing that the claustrum seems to be involved in switching the cerebral cortex between distinct states as well as how alcohol and psychedelics affect it"
X Link 2026-02-09T18:09Z 11.2K followers, [---] engagements

"I have reverse osmosis-filtered water at home. Recently asked a friend if he wanted a dash of salt in the glass of water he requested. He reacted like I was asking him to drink from the Dead Sea. Think salt causes high blood pressure Think again Studies show the opposite and that restricting sodium actually makes you more likely to die. Here I show the truth about salt and how many people have healed their fatigue simply by eating natural salt https://t.co/XSguj3Gaja Think salt causes high blood pressure Think again Studies show the opposite and that restricting sodium actually makes you more"
X Link 2026-02-09T20:53Z 11.2K followers, [----] engagements

"@CoachDanGo That's weird. When we look at data and evidence we see this:"
X Link 2026-02-09T22:42Z 11.2K followers, [----] engagements

"The flaw in this thinking is the implicit assumption that the grains widely consumed today are nutritionally interchangeable with those used by traditional cultures for centuries. "Bread is bad for you" "rice is bad for you"sorry I'm not subscribing to the idea that staple grains that have been integral to cultures for centuries are evil. I love you carbs. "Bread is bad for you" "rice is bad for you"sorry I'm not subscribing to the idea that staple grains that have been integral to cultures for centuries are evil. I love you carbs"
X Link 2026-02-09T22:58Z 11.2K followers, [----] engagements

"This is important. PUFAs go rancid both when they're sitting on the shelf and even after they enter your tissues. At some rate they will oxidize into cell toxins. The reason PUFAs in nature are always found packaged with antioxidants is because they go bad so easily. This is mistaken. Seed oils are never shelf-stable. They're used because they don't smell bad when they go rancid. But they are going rancid and that means toxic. They're in virtually everything processed because they're cheap shelf-stable and functionally versatile. This is mistaken. Seed oils are never shelf-stable. They're"
X Link 2026-02-10T19:03Z 11.2K followers, [----] engagements

"@Boudicca0000 @anonemus349832 Correct. Big difference between oxidation that happens "on purpose" in a regulated fashion (beta-oxidation) and oxidation that happens "on accident" in an unregulated fashion (lipid peroxidation)"
X Link 2026-02-10T19:26Z 11.2K followers, [--] engagements

"What exactly counts as "use" here How is "pot" defined For example is this THC use only or does someone taking a CBD tincture in the evening count as "pot use" If someone is hitting a dab rig every two hours and somebody else takes one [--] mg THC gummy daily do they both count as "daily users" and feed into the same line in the graph Most people are reacting to this graph without even asking themselves basic questions like this. [--] million Americans are smoking weed 21+ days a month This is a full blown addiction crisis that even the NYT now says: "Its Time for America to Admit That It Has a"
X Link 2026-02-10T22:54Z 11.2K followers, [----] engagements

"Apparently the most recent mass shooter in Canada was on not only a hefty dose of an SSRI but also sex hormone therapy and other psych meds AND potentially experimenting with DMT a potent psychedelics. Ive covered the effects of each of these things on the brain and behavior on several episodes of the podcast. Examples below. There is decades of evidence antidepressants cause mass shootings. From the start clinical trials showed SSRIs caused psychotic violence and suicides but industry hid it until lawsuits revealed it. This article shows just how far the FDA went to bury it"
X Link 2026-02-11T21:58Z 11.2K followers, [----] engagements

"If cannabis stocks had gone up instead down would the sentiment be the same We will never know for sure. All we can say for certain is that her marijuana investments didnt turn out how she hoped. Perhaps this a genuine change of heart or perhaps I worked in the marijuana industry for several years and noticed something. When capital was flowing in LOTS of people wanted in. And ALL of them had personal stories about how they loved the plant or whatever. The money waterfall eventually ended. And most of those people now have other stories. Coincidentally those stories align with all the places"
X Link 2026-02-12T02:21Z 11.2K followers, [----] engagements

"Was this unknown or did Vital Farms claim the chickens were NOT fed corn and soy feed My understanding is that pretty much all pastured chickens also always have access to supplemental feed. I prefer and would recommend eggs from chickens fed non-soy based feed for health reasons but if eggs arent explicitly labelled as such one should assume theyre getting supplemental feed which by default is likely corn/soy based. Did Vital Farms make claims that their chickens had soy-free diets even though they give them soy-based feed Vital Farms confirmed that its pasture-raised hens are routinely fed"
X Link 2026-01-18T17:38Z 11.2K followers, 17.3K engagements

"Glyphosate levels measured in a woman who eats all organic food. Reminder: glyphosate is metabolized into the toxin AMPA by the liver which drives neuroinflammation and stays in the brain long after exposure especially when choline deficient. To piggyback off of yesterdays bombshell glyphosate hearing in Floridahere is my recent lab work showing how much glyphosate is in my body as someone who eats ALL ORGANIC. This is a neurotoxin that Americans cannot escape from in our soil and water. It doesnt wash off https://t.co/u8TRr3bcr4 To piggyback off of yesterdays bombshell glyphosate hearing in"
X Link 2026-02-09T17:22Z 11.2K followers, 42.4K engagements

"My valentine this year. 💕 Dr. Simopoulos holds the distinction of being the oldest person ever on the podcast in her early 90s at the time of this interview. (Shes still alive). No notes. No questions in advance. No memory lapses in nearly two hours of continuous conversation. Shes long been one of the strongest proponents of eating a balanced -6:-3 fatty acid ratio minimizing [---] polyunsaturated fatty acid intake from seed oils and processed foods. A true OG in this area. https://twitter.com/i/web/status/2022726996544123280 https://twitter.com/i/web/status/2022726996544123280"
X Link 2026-02-14T17:37Z 11.2K followers, [----] engagements

"Analysis: true. A soon-to-be-published 16-week randomized controlled trial shows that consuming pasture-raised grass-fed beef actually decreases the -6:-3 ratio in humans (i.e. raises -3s relative to -6s). More detail in my recent conversation with the study author: Here's the simple reason why ruminant meat (beef lamb) is superior to monogastric meat (chicken pork). Monogastrics store whatever theyre fed. Grains in linoleic acid in their fat. Thats why pork fat = 20% PUFA chicken fat = 25% PUFA. They are literally swimming in Here's the simple reason why ruminant meat (beef lamb) is superior"
X Link 2026-02-14T18:49Z 11.2K followers, [----] engagements

"Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭 BTW the last citation below is a human trial that shows n-6 supplementation leads to an upregulation of inflammatory genes in human adipose tissue despite no increase in serum inflammatory markers. Virtually all the evidence that midwits like Colin cite relies on RCTs that only measure a small number of serum markers. Inflammation is multifaceted and often manifests in a tissue-specific manner. There is literally no evidence here really just means I am not familiar with"
X Link 2026-02-15T19:57Z 11.2K followers, [----] engagements

"@_OliverVenture https://x.com/trikomes/status/2023124521809830038 Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭 BTW the last citation below is a human trial that shows n-6 supplementation leads to an upregulation of inflammatory genes in human adipose tissue https://t.co/LUtuPhGOJc https://x.com/trikomes/status/2023124521809830038 Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭 BTW the last citation below is a human trial that shows n-6"
X Link 2026-02-15T20:24Z 11.2K followers, [---] engagements

"@SwipeWright He refuses to actually read any of the evidence to the contrary including human studies: Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭 BTW the last citation below is a human trial that shows n-6 supplementation leads to an upregulation of inflammatory genes in human adipose tissue https://t.co/LUtuPhGOJc Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭 BTW the last citation below is a human trial that shows n-6 supplementation"
X Link 2026-02-15T20:39Z 11.2K followers, [----] engagements

"This is plausible and related to why people are resort things like lower alcoholism on GLP-1s. Results so far are consistent with the interpretation that GLP-1s don't blunt hunger-for-food specifically but have a more general effect on reward processing. This fits with what we know about their effect on the pathway linking dietary [---] fats ("seed oils fat") to endogenous cannabinoid signaling. A previous generation of weight loss drug called Rimonabant more strongly inhibited cannabinoid signaling via CB1 receptor blockade. The result was weight loss. but also depression + suicidality in some"
X Link 2026-02-15T20:49Z 11.2K followers, [----] engagements

"Left: todays CGM data. First bump is two scoops of @mollymoon ice cream (during an outdoor walk). Second bump is a single large naval orange. Right: from a couple days ago. Basmati rice with eggs and mushrooms. The lowest glucose spike was from the ice cream. 🍨"
X Link 2026-02-05T23:14Z 11.2K followers, [----] engagements

"Two scoops of ice cream (@mollymoon mint brownie) gave me a glucose spike about half the size of a single naval orange. And much smaller than a meal with half cup of basmati rice (plus other things). Would popular store-bought ice creams have a different effect Left: todays CGM data. First bump is two scoops of @mollymoon ice cream (during an outdoor walk). Second bump is a single large naval orange. Right: from a couple days ago. Basmati rice with eggs and mushrooms. The lowest glucose spike was from the ice cream. 🍨 https://t.co/tzlaSBpv4U Left: todays CGM data. First bump is two scoops of"
X Link 2026-02-06T18:04Z 11.2K followers, [----] engagements

"Even just a few grams of glucose is enough to inhibit intense exercise-induced hypoglycemia which will greatly reduce feelings of fatigue. I personally put a couple teaspoons of dextrose (glucose) in my water bottle (plus electrolytes) for workouts. Works like a charm. More the data on this: https://twitter.com/i/web/status/2020195035896299542 https://twitter.com/i/web/status/2020195035896299542"
X Link 2026-02-07T17:56Z 11.2K followers, [----] engagements

"David Attenborough voice: As a social primate female Homo sapiens are naturally drawn to infants and hyper-sensitive to social reinforcement by peers. With one touch a newborn can trigger an intense reflexive response informally known as baby fever. It can be seen even in young females with no prior maternal experience. The experience triggers intense emotional reactions often stimulating females to aggregate together into groups sometimes numbering a dozen or more. But competition for the best mates is fierce. To sabotage opponents some females have worked to undermine their rivals by"
X Link 2026-02-08T22:22Z 11.2K followers, 83.9K engagements

"Psychedelics like psilocybin may reduce opioid-seeking behavior in animals by influencing neuroinflammation in key brain circuits involved in reward and addiction. That's covered in the newst M&M episode. Serotonergic psychedelics can have potent anti-inflammatory effects generally not just in the brain. M&M episode [--] covered this in detail. Link in bio. https://twitter.com/i/web/status/2022061604763054582 https://twitter.com/i/web/status/2022061604763054582"
X Link 2026-02-12T21:33Z 11.2K followers, [----] engagements

"Why has puberty onset shifted to younger and younger ages in girls over time At least part of the answer may be childhood obesity. Adipose (fat) tissue produces estrogen. Video clip below explains:"
X Link 2026-02-13T23:48Z 11.2K followers, [----] engagements

"Utilizing methods that would have been available in ancient Greece scientists were able to transform toxic alkaloids from the ergot fungus into non-toxic psychoactive compounds. Ergot is a fungus that infects cereal grains. LSD ("acid") is derived from ergot alkaloids. The results are consistent with the psychedelic Eleusis hypothesis about the Eleusinian Mysteries of ancient Greece. @BrianMuraresku wrote a fascinating book about this a few years back which was the subject of my very first podcast episode. https://twitter.com/i/web/status/2022486497602257079"
X Link 2026-02-14T01:42Z 11.2K followers, [----] engagements

"RT @trikomes: What you eat affects how sensitive your skin is to sunlight. Taking certain drugs or eating a certain diet can increase your"
X Link 2026-02-14T17:38Z 11.2K followers, [--] engagements

"This guy is highly religious. He places his faith in The Science. He posts these things because the topic is inflammatory (lol) and drives engagement. He does not actually read or scrutinize the meta-analyses he cites or the underlying RCTs. He takes what they say on faith. In this religion they worship the Great Pyramid of The Science. In this religion published papers are peer-reviewed and therefore must be Truth. If RCTs are published they must be rigorous and measure the correct things. Otherwise they wouldnt be published. The Science must work. Meta-analyses look at bunch of RCTs. They"
X Link 2026-02-15T18:12Z 11.2K followers, [----] engagements

"RT @TuckerGoodrich: He should speak to my wife. [--] years of untreatable pain from fibromyalgia gone in months. She gets a flair if she eat"
X Link 2026-02-15T18:12Z 11.2K followers, [--] engagements

"RT @trikomes: Analysis: true. Most modern neuroscience evidence is consistent with language being predominantly for communication not for"
X Link 2026-02-15T19:58Z 11.2K followers, [--] engagements

"RT @trikomes: Analysis: true. A soon-to-be-published 16-week randomized controlled trial shows that consuming pasture-raised grass-fed be"
X Link 2026-02-15T19:58Z 11.2K followers, [--] engagements

"RT @trikomes: Except of course for the evidence of this measured in human tissue. 🤷♂ This guy should change his name to Colin Wrong. 🤭"
X Link 2026-02-16T00:33Z 11.2K followers, [--] engagements

"RT @trikomes: @SwipeWright He refuses to actually read any of the evidence to the contrary including human studies:"
X Link 2026-02-16T00:34Z 11.2K followers, [--] engagements

"RT @trikomes: This is plausible and related to why people are resort things like lower alcoholism on GLP-1s. Results so far are consiste"
X Link 2026-02-16T01:04Z 11.2K followers, [--] engagements

"What you eat affects how sensitive your skin is to sunlight. Taking certain drugs or eating a certain diet can increase your sensitivity to sunburn and light-induced oxidative stress. Once you understand some basic things about the biology of oxidative stress this makes perfect sense. https://t.co/prvPVx0A2W https://t.co/prvPVx0A2W"
X Link 2026-02-13T20:51Z 11.2K followers, [----] engagements

"Analysis: true. Most modern neuroscience evidence is consistent with language being predominantly for communication not for thinking/reasoning. Brain damage can obliterate linguistic ability while leaving reasoning ability intact. Eve Fedorenko has done some of the best scientific work in this area. We literally know this isnt the case from brain damage patients who retain their reasoning abilities unaffected despite having their language center cooked and from all the living beings who have cognition despite not having language. But the techbro midwit is undeterred. We literally know this"
X Link 2026-02-14T23:42Z 11.2K followers, [----] engagements

"Imagine being a male prisoner in [----]. You start a fight in the cafeteria. Your punishment: they cut you down to [----] calories per day. In [----] ordinary male prisoners were fed [----] calories per day. With 550g() of carbs. [----] calories was considered a long term "Punishment diet". https://t.co/WBdU7JsMAt In [----] ordinary male prisoners were fed [----] calories per day. With 550g() of carbs. [----] calories was considered a long term "Punishment diet". https://t.co/WBdU7JsMAt"
X Link 2026-02-16T17:05Z 11.2K followers, [---] engagements

"Aura is real and probably has to do with the way energy emanates through tissues and mitochondria. Even raw anatomy (facial symmetry jawline etc.) depends on this. Gigachad has a highly efficient and unencumbered electron transport chain. Women dont care about muscles or even your face (per se). They care about overall presence: your confidence integrity competence values and the social proof that comes from living those things consistently. Women respond to how a mans energy makes them feel. Bioenergetics. Women dont care about muscles or even your face (per se). They care about overall"
X Link 2025-12-01T03:11Z 10.9K followers, [----] engagements

"Do you understand what alchemy is There's only [--] kind of people in life. Winners and Losers. https://t.co/k4mw7j2PQg There's only [--] kind of people in life. Winners and Losers. https://t.co/k4mw7j2PQg"
X Link 2025-12-01T03:31Z 10.9K followers, [----] engagements

"Wait until you find out how many billionaires and trillionaires there have been throughout history in places like Hungary and Zimbabwe. BREAKING: [--] in [--] adults in the US are millionaires. BREAKING: [--] in [--] adults in the US are millionaires"
X Link 2025-12-01T23:35Z 10.9K followers, [----] engagements

"You'll never guess what kind of dietary fatty acids promote gut inflammation gut dysbiosis and colon cancer"
X Link 2025-12-08T17:03Z 10.9K followers, [----] engagements

"Talking with @DominicDAgosti2 tomorrow in Tampa FL. We will cover: - Idea of preferred fuels for cellular energy transformation across behavioral and dietary contexts. - Ketogenic diet therapy for brain health & brain cancers. Post questions here"
X Link 2025-12-08T22:19Z 10.9K followers, [----] engagements

"Artemis Simopoulos is in her NINETIES. She does NOT wake up at 5am and lift weights. (She presumably does not dead lift at all). Talked to me for two hour straight. No notes. No questions in advance. Sharp as a tack. Her secret She knows how to read and interpret the literature better than most influencers. Guess what her view on seed oils is Twyla Tharp is tougher than you. Lifts weights 2hrs/day at 5am [--] days/week for 50+ years deadlifts 200lbs (2X her BW) then dance choreography other work rest of day. Eats no sugar no starches. [--] and sharp as a tack. Twyla Tharp on the Huberman Lab"
X Link 2025-12-09T01:34Z 10.9K followers, [----] engagements

"What lipidomics signatures predict preterm pregnancies Preterm births are associated with lipid imbalances and enrichment in PUFA metabolites"
X Link 2025-12-10T16:35Z 10.9K followers, [----] engagements

"In addition to being implicated in colon cancer high-fat diets rich in linoleic acid ("seed oil fat") but not other forms of fat lead to a dysregulated intestinal endocannabinoid system and inflammatory bowel disease. Dysregulation of endocannabinoid biology is also how high seed oil diets drive obesity in animals. Discussing this work on the podcast tomorrow. @luv2read13 Colon cancer is more about seed oils actually. https://t.co/65zymhOOrk @luv2read13 Colon cancer is more about seed oils actually. https://t.co/65zymhOOrk"
X Link 2025-12-15T01:09Z 11K followers, [----] engagements

"Can someone out there send me to the clearest examples of the Randle Cycle in action in vitro or in vivo I've struggled to find compelling work demonstrating the effect as I often see it described online. The Randle Cycle is often misunderstood. At the cellular level it describes how a single cell prioritizes burning either fat or carbohydrates at one time. This is a normal protective mechanism not a metabolic flaw. When you zoom out to the whole body different tissues use The Randle Cycle is often misunderstood. At the cellular level it describes how a single cell prioritizes burning either"
X Link 2025-12-15T17:35Z 11K followers, [----] engagements

"Loved this conversation with Dr. Sladek about the effects of soybean oil on obesity fatty liver and gut health. Among other things we talked about how animals can become obese + malnourished simultaneously including unpublished results on soybean oil & vitamin B1 deficiency Name one thing more relaxing than sitting next to a roaring fire on Sunday evening reading the literature on seed oil-induced gut dysbiosis and bowel inflammation. Ill wait. https://t.co/f58nVVJEL1 Name one thing more relaxing than sitting next to a roaring fire on Sunday evening reading the literature on seed oil-induced"
X Link 2025-12-15T21:16Z 11K followers, 21.1K engagements

"Weight gain fatty liver colon cancer gut dysbiosis etc. But sure some modern short-term trials (that almost always lack tissue-specific measurement of relevant markers) fail to find a problem and they lower LDL. Good luck with that. I don't know how so many people got suckered into the anti-seed oil position when they're clearly better for your health in trials. I feel very disappointed imagining that so many people can be convinced by arguments that ultimately boil down to the stuff not feeling natural. I don't know how so many people got suckered into the anti-seed oil position when they're"
X Link 2025-12-16T23:18Z 11K followers, [----] engagements

"Posts like this are mostly just an excuse for people to post pics of themselves without explicitly shouting "Look at me Look at me" I live near the International District in Seattle. Go to the Asian market all the time. Tons of old Asian guys who look like they survived the WWII era chain smoking cigs everyday. The argument below is as dumb as looking at cig-smoking nonagenarians and concluding that cigarettes can't be bad. Probably dumber than that actually as there's no way that ranchers working outside all day eat seed oils at the levels of the average American or with lifestyles that"
X Link 2025-12-17T03:11Z 11K followers, 37.8K engagements

"Psychonaut-philosopher Terence McKenna died from a aggressive form of brain cancer (glioblastoma) in [----]. A new animal study has found that the activity of serotonin neurons in the brain drives glioma proliferation. The effect is mediated by the serotonin 2A receptor the "psychedelic receptor" that psychedelics like psilocin act on. They found that serotonergic psychedelics promote malignant cell proliferation. The results imply that any drug that boosts serotonin signaling via the 2A receptor could have a similar effect. For example SSRIs boost synaptic serotonin generally some of which"
X Link 2025-12-17T13:00Z 11K followers, 27.7K engagements

"@noetechnesis Sometimes it's easy (for me) to forget that for many people "scientific consensus" is literally whatever turns up in the AI-generated top result of a Google search based on studies they haven't every looked at or scrutinized themselves"
X Link 2025-12-17T19:15Z 11K followers, [---] engagements

"Even for the claimed benefit for cardiovascular disease risk it turns out the result doesn't hold up if you're careful to sort the clinical trials based on whether they were adequately vs. inadequately controlled. In other words the "top-tier evidence" (meta-analyses) suggesting seed oil fats are good for heart health lumped together trials with variable levels of quality and control. If you look specifically at adequately controlled trials the supposed benefits go away This is why you should Check the Science not blindly Trust the Science. https://t.co/Mulqbp3NO0 https://t.co/Mulqbp3NO0"
X Link 2025-12-17T21:13Z 11K followers, [----] engagements

"I once ran into Noam Chomsky at Logan airport in Boston standing in the security line. He he told me he was off to New York. I wonder what he did there. The fall of man. Noam Chomsky the worlds most famous critic of power structures photographed at [-----] feet with Jeffrey Epstein. https://t.co/zi05lGSrfX The fall of man. Noam Chomsky the worlds most famous critic of power structures photographed at [-----] feet with Jeffrey Epstein. https://t.co/zi05lGSrfX"
X Link 2025-12-19T18:40Z 11K followers, [----] engagements

"Reminder that glyphosate is metabolized into the toxic compound AMPA which can persist and drive inflammation in the brain long after an animal's last glyphosate exposure. Sometimes you hear people argue that there's no evidence glyphosate is toxic to animals which is either ignorant of the metabolic reality or else a sleight-of-hand trick because AMPA is not glyphosate per se. Choline deficiency makes glyphosate-induced neuroinflammation worse as it does other health problems like fatty liver disease. Choline is found naturally in animal foods not plant foods. Deficiency leads to all sorts"
X Link 2025-12-21T20:55Z 11K followers, [----] engagements

"How would you explain this pattern Seem to be stuck at [---] lbs despite progressive strength gains. Body fat stable 13-14% Consuming [----] or so calories/day (whole foods) Naturally sleeping a bit more each night than I used to before resistance training this much (5x per week) sometimes with additional short nap during the day. Genuinely stuck or just being impatient Need to eat even more If the goal was [--] more pounds of lean mass what should I do to build and maintain naturally"
X Link 2025-12-21T22:49Z 11K followers, [---] engagements

"This happens A LOT in academic science. For example in otherwise great work by Blenis et al. they show that linoleic acid drives triple-negative breast cancer via an mTOR mechanism but. . in their explainer graphic they chose to use a bottle of seed oil (good representation of high linoleic acid) plus a beef steak (poor choice). When I asked about this they seemed to have little to no idea that lots of other foods have way higher linoleic acid content than beef fat including the fat of non-ruminant animals such as chicken (which people have shifted to way more over time). My impression was"
X Link 2025-12-23T19:08Z 11K followers, [----] engagements

"And what is resolution driven and constrained by This is why things like n-3:n-6 balance are crucial and why we consistently find "failure of resolution" when there's overconsumption of n-6 PUFAs. n-6s and n-3s are often functionally opposed and they are non-interconvertible in creatures like us. Hence relative ratio matters. When it's out of balance you get inflammatory states that fail to resolve"
X Link 2025-12-23T20:45Z 11K followers, [---] engagements

"If the United States was an animal what animal would it be Its not just daycares Somalis in Minnesota have been setting up fake medical centers and fraudulently diagnosing their children with autism to systematically steal billions of taxpayer dollars through Medicaid. Medicaid autism claims: [----] - $3 million [----] - $399 million https://t.co/Mg4anQmoLp Its not just daycares Somalis in Minnesota have been setting up fake medical centers and fraudulently diagnosing their children with autism to systematically steal billions of taxpayer dollars through Medicaid. Medicaid autism claims: [----] -"
X Link 2025-12-30T03:59Z 11K followers, [---] engagements

"New podcast episode is a deep dive into how exercise performance is affected by carbohydrate intake such as high-carb vs. ketogenic diets. Among other things we talk about how it's possible to exhibit signs of relatively poor metabolic health despite being lean and athletic. We also dig into the widespread belief that high-carb intake is needed for peak physical performance. Is this actually true https://twitter.com/i/web/status/2006157640523735291 https://twitter.com/i/web/status/2006157640523735291"
X Link 2025-12-31T00:17Z 11K followers, [----] engagements

"@MDVilntfluid That's tributyltin (TBT) a highly toxic organotin compound. See this work and episode:"
X Link 2026-01-05T20:17Z 11K followers, [--] engagements

"He's missing something big here. Omega-6 PUFAs (seed oil fat) are directly linked to eating more through a well-defined pathway that regulates food palatability and energy storage: endogenous cannabinoid signaling through the CB1 receptor. Blocking the increase in endogenous cannabinoid signaling driven by increased linoleic acid intake blocks many of the obesogenic effects of a high linoleic acid diet. The "Western diet" is a high linoleic acid diet. Signaling through CB1 drives metabolic changes throughout the body's tissue systems that favor energy intake and storage. There is a lot of"
X Link 2026-01-08T19:52Z 11.1K followers, [----] engagements

"The amino acid composition and digestibility of proteins varies quite a bit across individual protein sources as well as between plant vs. animal foods generally. As a result different anabolic responses will be stimulated in skeletal muscle depending on the protein source"
X Link 2026-01-08T23:30Z 11.1K followers, [----] engagements

"Which foods tend to result in the biggest glycemic responses Overall rice was the most glucose-elevating carbohydrate meal although there was A LOT of variability between individual responses. Ethnicity was also a factor: Asian and non-Asian people had different odds of being "rice spikers" (big glucose spikes to rice)"
X Link 2026-01-11T00:51Z 11.1K followers, 11.7K engagements

"@exfatloss Just from a general carb:fat:protein balance perspective the Standard American Diet is close to ideal for driving fat gain"
X Link 2026-01-11T16:11Z 11.1K followers, [---] engagements

"Neoteny is the retention of juvenile characteristics into adulthood. Commonly observed in domesticated species. When humans domesticate wild animals they tend to display more neoteny over time. Note that adult human skull shape more closely resembles juvenile chimpanzees than it does adult chimps. What is happening to men This cannot only be about the collapse in testosterone https://t.co/dq7rWDYakr What is happening to men This cannot only be about the collapse in testosterone https://t.co/dq7rWDYakr"
X Link 2026-01-11T18:45Z 11.1K followers, 70K engagements

"When I worked in the marijuana industry people made all sorts of cannabinoid gummies marketed for different effects: sleep energy stress etc. The non-THC stuff never caused a noticeable effect for me perhaps because most products contained low amounts (10mg) of cannabinoids. Someone convinced me to try a Cordyceps mushroom extract gummy product recently each with 300mg of mushroom extract. Two of these causes a noticeable "mental energy" affect in me. Looked into it and there is some literature on Cordyceps affecting both exercise performance in humans and cellular ATP production in rodents:"
X Link 2026-01-12T19:37Z 11.1K followers, [----] engagements

"Coincidentally these high carb diets are almost invariably high in something else 🤔 One of the biggest diet misconceptions is that carbohydrates are essential for health. In reality most chronic diseases in the United States are directly linked to high-carb diets. One of the biggest diet misconceptions is that carbohydrates are essential for health. In reality most chronic diseases in the United States are directly linked to high-carb diets"
X Link 2026-01-15T18:49Z 11.1K followers, [----] engagements

"Something most people including smart people seem to forget over and over is that most exponential growth curves are just sigmoids that havent played out yet. Exponential growth slows. Infants dont weigh a trillion pounds in a few years. Ben Affleck gets it. Who knew. 🤷♂ Honestly Ben Affleck actually knowing AI and the landscape caught me off guard but as a writer makes sense. Great takes across the board. https://t.co/IcPe0n9302 Honestly Ben Affleck actually knowing AI and the landscape caught me off guard but as a writer makes sense. Great takes across the board. https://t.co/IcPe0n9302"
X Link 2026-01-18T18:08Z 11.1K followers, [----] engagements

"This is a consistent pattern in health "debates" like this. The so-called experts (Attia Norton) cannot accurately and honestly describe the studies they are themselves referring to. But to the average listener it all sounds like smart guys saying smart guy things. Geez. [--] minute in and Norton says one of the strongest studies is the Finnish Mental Hospitals Study. This is NOT a randomized controlled trial It is often FALSELY included in meta-analyses of RCTs. Layne calls it a crossover design. He says people were crossed over Geez. [--] minute in and Norton says one of the strongest studies"
X Link 2026-01-19T22:53Z 11.1K followers, [---] engagements

"Trying my best to book 2-3 podcast guests this week so that I can keep consistently publishing content through the next two weeks while traveling. Heading to Arizona + Mexico next weekend to escape the dreary PNW winter and get some strong unadulterated sunlight"
X Link 2026-01-19T23:16Z 11.1K followers, [---] engagements

"Taurine is an amazing fascinating compound. One of the few things I supplement with regularly. Taurine naturally declines with age and reversal of this decline with supplementation increases lifespan + healthspan in species as diverse as yeast worms rodents and primates. Taurine improves literally every metric of insulin resistance across multiple studies. New review finding taurine supplementation: Fasting blood glucose: [----] mg/dL HbA1c: 0.21% Fasting insulin: 10-20% HOMA-IR: [----] Triglycerides: [-----] mg/dL Total https://t.co/QwrLmlBhMw Taurine improves literally every metric of insulin"
X Link 2026-01-19T23:28Z 11.1K followers, [----] engagements

"Interesting. SoS actually tested various egg brands. Many still don't realize that nutrition labels on food packaging don't actually reflect genuine test results for that particular product. As you may have noticed at the grocery store all cartons of eggs have the same nutrition facts. We ACTUALLY analyzed every egg in Whole Foods to confirm if these results were the real deal Vital Farms eggs from [--] different producers were put head-to-head against the nation's best soy-free low omega [--] eggs Before you boycott some Vital Farms producers actually had the https://t.co/YsqAEyygli We ACTUALLY"
X Link 2026-01-20T19:20Z 11.1K followers, [----] engagements

"It still baffles me sometimes that people on both "sides" of this issue can't figure out how to hold multiple ideas in their head at once and integrate them. GLP-1 drugs are effective at weight loss. for many but NOT all people. It's something like an 80/20 split I believe. Caloric input/output is sufficient to explain obesity and weight loss. for many but NOT all people. SOME people do have a "broken metabolism" even though for many others calorie surplus is sufficient to explain their weight gain. There are many ways that metabolism can "break" such that the same level of calorie intake"
X Link 2026-01-20T20:53Z 11.1K followers, [--] engagements

"Imagine an individual who consume X calories with no weight/fat gain. After some type of metabolic disruption (e.g. BPA exposure leading to enhanced insulin signaling) the same exact input might now lead to weight/fat gain because the same input stimulus now drives an exaggerated hormonal signaling response. In at neither timepoint are the laws of thermodynamics violated but the same inputs drive different tissue outputs before vs. after the exposure. https://twitter.com/i/web/status/2013798299728552004 https://twitter.com/i/web/status/2013798299728552004"
X Link 2026-01-21T02:18Z 11.1K followers, [---] engagements

"If people want to learn the relevant biology here and not keep seeing the same four influencers talk about each other ad nauseum I recommend following @ChrisMasterjohn and @TuckerGoodrich. The following articles also lay out some of the biology with plenty of graphics data and primary sources. https://twitter.com/i/web/status/2014744687693987974 https://twitter.com/i/web/status/2014744687693987974"
X Link 2026-01-23T16:59Z 11.1K followers, [----] engagements

"Some people are more resistant to weight gain and obesity than others. Lots of variance in weight gain between individuals even when they consume same level of excess calories. Identical twins overfed [----] extra kcal/day for [--] months gained 4-13 kg. Variance mostly between pairs pointing to genetic differences. Talking with @jens_lund about this topic in a couple weeks"
X Link 2026-01-24T20:11Z 11.1K followers, [----] engagements

"The vast majority of studies linking "high-fat" diets to negative outcomes are preclinical studies in which mice are fed chow made of things like soybean oil and refined carbs. They are "high fat" in the sense that more calories are from fat compared to "standard chow" but are not ketogenic and often have substantial carbohydrate content. I can tell you from experience--both in my research days studying feeding behavior and talking to dozens of researchers on my podcast who work on this stuff--that the vast majority do not actually know what the nutrient content is of the "high fat" diets"
X Link 2025-01-27T02:47Z 11.1K followers, [----] engagements

"I did some contract work for a dating app startup last year. Exposed me to lots of interesting analytics. Everyone knows women tend to express a strong preference for taller men. At the same time they often misjudge height often perceiving a man to be taller than his actual height e.g. see a guy under [--] whos taller than them and when asked his height guess hes over [--]. Dating apps often now have height filters so women can filter out men under a certain threshold. Many apps are now adding height verification so men cant lie about their actual height. That combination of features means that"
X Link 2026-01-19T17:42Z 11.1K followers, [----] engagements

"Recording a deep dive on AMP-activated protein kinase (AMPK) tomorrow. AMPK is an enzyme that senses nutrients and regulates metabolic activity across tissues timescales and cell types. Critical player in cell energy metabolism"
X Link 2026-01-20T19:35Z 11.1K followers, [---] engagements

"Analysis: true. Linoleic acid (seed oil fat) derivatives causally modulate pain sensitivity in animals. The same compounds are associated with chronic headache in humans and sufferers report fewer headaches after reducing dietary linoleic acid intake. Inflamed and itchy human tissue (skin) is also highly enriched in such PUFA derivatives. https://t.co/tKAI6FkATw https://t.co/tKAI6FkATw"
X Link 2026-01-25T17:04Z 11.1K followers, [----] engagements

"Lots of people out there seem to genuinely believe that unless something has been measured in one of the 8-12 week (short-term) RCTs theyre personally aware of it doesnt and cant exist. @PragmaticNurse @LennaVelaryon @trikomes I did plenty of research on the matter myself a podcast isnt evidence. If that pufa wildfire on a cellular basis were real in humans it would show up in rcts. But it doesnt all of this is just echanistic speculation that doesn't work when we analyze real health outcomes @PragmaticNurse @LennaVelaryon @trikomes I did plenty of research on the matter myself a podcast isnt"
X Link 2026-01-26T23:09Z 11.1K followers, [----] engagements

"@DamianMihaii @SeedOilDsrspctr @PragmaticNurse @LennaVelaryon Show us your favorite one whichever you find the most compelling and rigorous. Let's take a close look at their measurements controls etc"
X Link 2026-01-27T17:26Z 11.1K followers, [--] engagements

"ALA is poorly converted to EPA/DHA by our cells. Youll have to consume an ungodly mass of such foods to golden to hit your EPA/DHA requirements. Good luck with that. You dont need fish for omega-3s. 🐟🚫 Chia flax walnuts and algae supplements have you covered. #PlantBased #Omega3 https://t.co/UBKKAqB57q You dont need fish for omega-3s. 🐟🚫 Chia flax walnuts and algae supplements have you covered. #PlantBased #Omega3 https://t.co/UBKKAqB57q"
X Link 2026-01-28T23:45Z 11.1K followers, [----] engagements

"If you're interested in getting kidney stones then you should try eating lots of spinach. Spinach contains a lot of oxalates. Dr. Weimbs considers spinach to be a non-edible toxic plant. MYTH: high protein intake is harmful to kidneys. Kidney biologist @weimbslab explained the origins of this myth to me in a previous podcast (M&M 186). In short the guy who hypothesized this idea was also the guy who wrote the major kidney textbook used in medical schools. https://t.co/yNOoI7rtxE MYTH: high protein intake is harmful to kidneys. Kidney biologist @weimbslab explained the origins of this myth"
X Link 2026-02-03T19:49Z 11.1K followers, [----] engagements

"🤣😂😆 Protein bars are uncool and you're a loser if you eat them especially David bars. Dr. Peter Attia has stepped down from his role as Chief Science Officer at David. We remain focused on serving our customers. Dr. Peter Attia has stepped down from his role as Chief Science Officer at David. We remain focused on serving our customers"
X Link 2026-02-03T19:58Z 11.1K followers, [----] engagements

"If the Bill Gates STD thing is true it just blows my mind. The guy who pushed jabs and rapid PCR testing on the whole planet didnt get his hookers tested for the clap before awkwardly humping them. And THEN went home to Melinda. We are ruled by dweebs and imbeciles"
X Link 2026-02-03T22:36Z 11.1K followers, [----] engagements

"@BFuentes74571 Im not just doesnt make a whole lot of sense for someone with low testosterone. 🤷♂"
X Link 2026-02-05T00:38Z 11.1K followers, [---] engagements

"If everything gets better when the number gets lower why would our bodies produce LDL at all 🤔🤔🤔 Across trials genetic variants and longitudinal studies the more LDL goes down the lower the risk of heart disease falls. The evidence on this is extremely clear: get LDL down and heart disease risk declines with it. https://t.co/V3aDC36M6x Across trials genetic variants and longitudinal studies the more LDL goes down the lower the risk of heart disease falls. The evidence on this is extremely clear: get LDL down and heart disease risk declines with it. https://t.co/V3aDC36M6x"
X Link 2026-02-05T19:42Z 11.1K followers, 10.4K engagements

"Friendly reminder that people in developed countries have been eating 10% calories from linoleic acid for many years. Many consume more than that and probably have for a long time. Were talking an order or magnitude more than any known pre-industrial population. More than 10% of calories from a single molecule. And many fail to think about this when evaluating clinical trials or ever considering that it might affect the interpretation of results or what a change from baseline should be taken to mean. The baseline human diet has been becoming more and more high-linoleic acid for over a"
X Link 2025-11-01T21:37Z 11.2K followers, 27K engagements

"@grifterlouie This hints at another problem with many studies: our baseline is already a high linoleic acid diet. As a result one may fail to see and increase in certain markers because theyre already elevated from the start"
X Link 2025-11-01T20:50Z 11.2K followers, 27.1K engagements

"The body's sensitivity to the world depends on what you feed it. More hyperlinks to sources in original article. Not medical advice. Podcast episodes that informed this article: M&M 233: Feel the http://x.com/i/article/1940209330235871232 http://x.com/i/article/1940209330235871232"
X Link 2025-07-02T03:49Z 11.2K followers, 11.2K engagements

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