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@angryhacademic ""Neurons heavily rely on mitochondrial oxidative phosphorylation to meet their instant energy demands.in contrast to many cell types neurons have evolved to master altering mitochondrial functions by rapidly promoting mitochondrial plasticity in response to neuronal activity""
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements

""Mitochondrial DNAs lack protection from methylation & are exposed to high levels of ROS. Ca2+ & other ions neurotransmitters stressors & toxins that accumulate inside the synapses as a result of neuronal activity excitotoxicity & aging make synaptic mitochondria"
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements

"ME patients seem unable to tolerate many stressors - are these directly damaging nerves more so than in healthy people "mitochondria may undergo dynamic fission-and- fusion at the synapses like in most other types of cell to discard refresh or exchange their contents""
X Link @angryhacademic 2025-10-16T21:48Z 8756 followers, X engagements

"Luckily my dentist seems understandingwhilst the clinic (last time) no longer had any respirators due to gov rule changes and funding (🙄) they will at least wear a FFP3 if i bring one and they let me have my mini HEPA running near my face holes. But its still unduly risky 😭"
X Link @angryhacademic 2025-10-13T16:24Z 8755 followers, XXX engagements

""Therefore mitochondrial ROS serve as double-edged sword in host defense and pathological inflammation during infection" ROS = reactive oxygen species AKA oxidative stress ("opposite" of antioxidants which counteract this)"
X Link @angryhacademic 2025-10-14T22:55Z 8756 followers, XX engagements

"This clip to me was a microcosm of what many of us experience. We sound completely bonkers to drs who dont understand our reality the research the lived experience etc. They dont know what they dont know"
X Link @angryhacademic 2025-10-07T00:43Z 8756 followers, XX engagements

"The paper describes the non-uniform distribution of glucose transporters and that metabolic enzymes and mitochondria can be shuffled to response to nutrient flux and energy demands"
X Link @angryhacademic 2025-10-16T21:48Z 8756 followers, XX engagements

"Some more info/cautions here:"
X Link @angryhacademic 2025-10-14T21:31Z 8754 followers, XX engagements

"@TJerryfan @laura_skaife @NHSGrampian Indeed. Also hospitals have green targets and AI is an environmental disaster. And more widely if we scap a bunch of jobs the benefits bill rises. This is a bad idea on so many levels"
X Link @angryhacademic 2025-10-15T15:54Z 8757 followers, XX engagements

"Cognitive and mental health outcomes in long covid Rapid Response: Research must consider Post Exertional Malaise as a neurological event underpinning fluctuating cognitive dysfunction in Long Covid Excellent letter by Dr Selina Shaw"
X Link @angryhacademic 2025-10-14T20:57Z 8756 followers, XXX engagements

"Fun fact: pangolin scales are sharp along the edges and so strong that often even animals like lions cannot penetrate their armour - instead they leave the pangolin alone with their mouth maybe a bit cut up"
X Link @angryhacademic 2025-10-07T18:40Z 8755 followers, XXX engagements

"Equally some patients (like me) find sugar/carbs to actively help symptoms and maybe that's because there's greater demand for energy and/or less efficient metabolism in the neurons (and in this subgroup we don't have CNS insulin resistance/similar)"
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements

".prone to damage. Mitochondrial vulnerability is further exacerbated by the high energy requirements of neurons. Damaged mitochondria are not only detrimental locally at the synapse but can also trigger systemic immune responses""
X Link @angryhacademic 2025-10-16T21:48Z 8756 followers, XX engagements

"Has anyone who takes calcium channel blockers (e.g. for high blood pressure) found that their MCAS symptoms improved They seem to have some mast cell stabilising effects"
X Link @angryhacademic 2025-10-15T22:42Z 8757 followers, XXX engagements

"Has anyone tried vinpocetine Allegedly: 🧠 Enhance memory and brain metabolism 🩸 Used in ischaemia reperfusion injuries 🪖 Considered neuroprotective ❌ But not much research to support it's use in stroke dementia or other CNS diseases"
X Link @angryhacademic 2025-10-14T21:31Z 8756 followers, XXX engagements

"Inhibition of allergic & non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists Off label theyre also sometimes used for Raynaud's and psychiatric conditions like bipolar disorderboth may also have mast cell involvement"
X Link @angryhacademic 2025-10-15T22:42Z 8756 followers, XXX engagements

"Neuronal activity translocates glucose transporters to presynaptic plasma membrane and under stress metabolic enzyme colocalise to form metabolic pockets at the nerve terminal and this enhances glucose influx & promotes breakdown of glucose for energy"
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements

""Brain stimulation causes transient uncoupling between them which indicates the utilization of glucose through aerobic glycolysis" Many ME studies find problems specifically with aerobic metabolism - and with ME comes a raft of neurological problems"
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements

""Moderate levels of mtROS are often induced by danger signals such as bacterial endotoxin LPS which play a crucial role in regulating the inflammatory response. High levels of mtROS activation can initiate apoptosis & autophagy cell death pathways""
X Link @angryhacademic 2025-10-14T22:55Z 8756 followers, XX engagements

"SARS-CoV-2 may cause mitochondrial fission/fusion issues. This paper discusses the role of melatonin: Melatonin may aid in nerve repair via Parkin: And the paper discusses the role of Parkin in mitophagy:"
X Link @angryhacademic 2025-10-16T21:48Z 8757 followers, XX engagements