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@andrewcaravello "⚙ Eden Was Built for $NWBO Boosters Like This: Inside the Patent That Proves It When people hear Flaskworks Eden they think: closed automated dendritic cell manufacturing. But thats only half the story. The real value of Eden is whats injected into the system the logic modules reagents and immune inputs that shape what the final dendritic cells become. And it turns out agents like ensifentrine (Mercks PDE3/4 inhibitor) and brensocatib (Baker Bros DPP1 inhibitor) arent just compatible with this platform Theyre what it was built for. 🔬 What the Eden Patent Actually Says The Eden patent"
@andrewcaravello on X 2025-07-24 23:22:14 UTC 1088 followers, 2448 engagements

"The Flux Capacitor let us travel through time. Eden lets us program the immune system in real-time. XX mph Try X L/min per inlet. Booster logic routed. Dendritic cells engaged. This is how you compile memory. 🧬⚡ 📎 US10647954B1 #Immunotherapy $NWBO $MRK"
@andrewcaravello on X 2025-07-24 23:28:12 UTC 1088 followers, 1537 engagements

"🧬 The vaccine produced helps protect individuals against diseases and related cancers. Merck 63A West Point Facility $MRK $NWBO $IBRX Thats not a generic statement. Its a quiet blueprint. Because in three Mayo Clinic trials Mercks own vaccines werent used to prevent cancer they were injected into tumors alongside dendritic cell vaccines to treat it. These werent theoretical experiments. They were full-phase human trials using a validated M7-style DC platform: Autologous monocyte-derived DCs matured ex vivo and injected into cryoablated tumor tissue. 🔁 Mayos Human Trials: DC Vaccines + Merck"
@andrewcaravello on X 2025-07-22 19:34:44 UTC 1088 followers, 2664 engagements

"continued $NWBO $MRK $BMY $AZN $JNJ $PFE $NVS $LLY $REGN $AMGN $GILD $RHHBY $ROG.VX $BIIB $SGEN $VRTX $NBIX $INCY $BGNE $MDGL $EXEL $ACAD 🧬 X. Replacing Chemoand Eventually Surgery DCVax is immunologically constructive. Chemo is destructive. And with DCVax-Direct intratumoral injections can: Cause in situ vaccination Shrink tumors Release danger signals that retrain the immune system Stacked with IL-7 cytokines or checkpoint inhibitors this platform could eliminate the need for debulking surgery in some settings. 🔄 The Self-Feeding Immune Loop DCVax sets in motion a loop: 1.Priming Trains"
@andrewcaravello on X 2025-06-06 02:32:36 UTC 1086 followers, 1313 engagements

"@TonyVerazzanno youre right that no collaborative agreement has been publicly disclosed with $NWBO. But the absence of a press release isnt the same as the absence of alignment. There are multiple functional operational and clinically validated links between WP50 and the DCVax platform that go well beyond theory. X. The booster agents Merck fills have already been used with dendritic cell vaccines Mercks own products (Prevnar XX and Pneumovax 23) were used as intratumoral immune primers in human trials alongside dendritic cells matured with the same cytokine and antigen-pulsing process DCVax"
@andrewcaravello on X 2025-07-24 12:09:27 UTC 1086 followers, XXX engagements

"🫆 The Traceability Engine Why $NWBO Flaskworks Eden May Be the Only Platform Truly Built for the Next Era of Immunotherapy In an age of regulatory transformation and decentralized manufacturing the immunotherapy landscape is quietly bifurcating: platforms that look scalable and platforms that are scalable. At the center of this divide sits Flaskworks Eden a modular cassette-based dendritic cell (DC) manufacturing system developed not as a generic automation tool but as a purpose-built infrastructure to support traceable autologous immunotherapy at scale. It is by many measures the only one"
@andrewcaravello on X 2025-07-25 03:32:39 UTC 1088 followers, XX engagements

"Tony Youre right that no collaborative agreement has been publicly disclosed. But the absence of a press release isnt the same as the absence of alignment. There are multiple functional operational and clinically validated links between WP50 and the DCVax platform that go well beyond theory. X. The booster agents Merck fills have already been used with dendritic cell vaccines Mercks own products (Prevnar XX and Pneumovax 23) were used as intratumoral immune primers in human trials alongside dendritic cells matured with the same cytokine and antigen-pulsing process DCVax uses today. Those same"
@andrewcaravello on X 2025-07-24 12:07:29 UTC 1080 followers, X engagements

"💣 The Silent Bomb: How Mercks Legacy Vaccines and Mayos Trials Quietly Validated $NWBO s Immune OS 🧵 TL;DR: Estimated Read Time: 1720 minutes $MRK Prevnar and Pneumovax werent just background vaccinations they were used intratumorally in Mayo Clinic dendritic cell trials to amplify immune responses alongside cryoablation and PD-1 inhibitors. The same vaccines are now likely under evaluation by NWBO via a Material Transfer Agreement while the company consolidates the lysate infrastructure dendritic cell maturation protocol and GMP automation needed to recreate that system at scale. With"
@andrewcaravello on X 2025-07-22 17:09:30 UTC 1088 followers, 3724 engagements

"📄 Why the July XX NICE Letter Strongly Suggests $NWBO Is in the Final Step: Labeling A step-by-step breakdown for those trying to decode the regulatory silence Lets walk through what the July XX NICE letter actually says what it doesnt say and why all roads point to one conclusion: MHRA labeling is happening right now. X What the Letter Says NWBO is still fully occupied and engaged in the Marketing Authorisation Application (MAA) process with the MHRA. The company is not yet in a position to provide their evidence submission This tells us two things: ✔ NWBO is still in active dialogue with"
@andrewcaravello on X 2025-07-15 20:44:28 UTC 1088 followers, 2088 engagements

"🔍 If the July XX NICE Letter Is Real Then MHRA Approval Is Functionally Complete Heres the Step-by-Step Explanation: ⚠ This analysis assumes the July XX 2025 letter from NICE is genuine and accurately reflects $NWBO current status in the UK regulatory process. As per the actual NICE submission manual. That document makes one thing clear beyond all doubt: The statement from NICE that NWBO is not yet in a position to submit does not signal delay or failure. It is exactly what we would expect at the very end of the regulatory process during the labeling phase. 📄 Direct link to the NICE"
@andrewcaravello on X 2025-07-15 18:11:38 UTC 1085 followers, 4026 engagements

"🧬 The Cancer Vaccine Revolution Wasnt Supposed to Look Like This Merck quietly tested it Mayo Clinic clinically proved it Now $NWBO owns the patents that make it possible Vaccines are no longer just for prevention Theyre becoming immune ignition switches inside tumors against viruses and soon at scale 🔄 Mayos Trials Showed the Method Dendritic cells injected into tumors Primed with tumor lysate and Prevnar13 or Pneumovax XX Layered with pembrolizumab Used in melanoma B-cell lymphoma and HIV-related cancers These werent theoretical experiments They were full-phase human trials using M7-style"
@andrewcaravello on X 2025-07-22 20:00:45 UTC 1088 followers, 1478 engagements

"💉 The Deployment Engine: How $MRK West Point Expansion May Plug Directly into $NWBO s Immune OS What if Mercks $1B vaccine infrastructure isnt just about pandemics or infectious disease What if its about cancer Mercks West Point campus in Pennsylvania isnt just massive its purpose-built for industrial-grade syringe filling packaging and formulation. Recent expansions include: B63 a facility approved in 2019 for large-scale pre-filled syringe output. B63A a sister facility completed by KeyPlants capable of XX million pre-filled syringes annually. And now a new expansion adding 175000 sq ft to"
@andrewcaravello on X 2025-07-22 18:14:59 UTC 1088 followers, 2105 engagements

"💣The Silent Bomb: How Mercks Legacy Vaccines and Mayos Trials Quietly Validated $NWBO s Immune OS 🧵 TL;DR: Estimated Read Time: 1720 minutes $MRK Prevnar and Pneumovax werent just background vaccinations they were used intratumorally in Mayo Clinic dendritic cell trials to amplify immune responses alongside cryoablation and PD-1 inhibitors. The same vaccines are now likely under evaluation by NWBO via a Material Transfer Agreement while the company consolidates the lysate infrastructure dendritic cell maturation protocol and GMP automation needed to recreate that system at scale. With"
@andrewcaravello on X 2025-07-22 16:52:46 UTC 1082 followers, XXX engagements

"🧬 The $NWBO Standard They Cant Reach Why #DCVax Is the Only Real Dendritic Cell Vaccine Platform TL;DR: 1922 min. Based on The Lancets 2025 review DCVax is the only dendritic cell platform to show Phase III survival benefit operate across GBM types use full lysate personalization and reach real patients under active regulatory pathways. It isnt theoretical. Its already workingand now finally seen. 🧘♂ X. The Gold Standard in a Fragmented Field Do you have the patience to wait till your mud settles and the water is clear Can you remain unmoving till the right action arises by itself Lao Tzu"
@andrewcaravello on X 2025-07-23 22:45:25 UTC 1088 followers, 2998 engagements

"$NWBO 🧠 Why the XX Billion Dollar Merck and Daiichi Deal Might Be Just the Beginning of Something Much Larger: #DCVax In 2023 Merck paid XX billion dollars to co-develop three antibody drug conjugates from Daiichi Sankyo. That included X billion upfront XXX billion in options and the rest tied to milestones. The message was clear. Merck was assembling a next-generation cancer stack. But despite its size that deal did not include the most important layer the adaptive immune intelligence that tells you what to target in the first place. That layer is DCVax. 🎯 What ADCs Are Designed to Do and"
@andrewcaravello on X 2025-06-29 19:37:15 UTC 1088 followers, 5272 engagements

"$NWBO The Immune Engine That Teaches Itself Roswell Park has done extensive work optimizing dendritic cell (DC) vaccines using specific cytokines to guide how monocytes differentiate into potent mature dendritic cells. Their cocktail includes: GM-CSF + IL-4 Used to turn monocytes into immature DCs. DCVax already uses these. TNF- IL-1 IL-6 and IFN- Added to mature the DCs and boost immune-stimulating power. PGE2 Sometimes used to promote lymph node migration aiding T-cell activation. These generate Th1-polarizing DCscritical for initiating strong cytotoxic T-cell responses and building immune"
@andrewcaravello on X 2025-06-06 02:31:22 UTC 1086 followers, 5561 engagements

"$NWBO Paul Mulholland just cured GBM in a trial he led. But heres what they dont print: He also presented DCVax-Ls Phase X survival data. Same institution. Same immune model. DCVax teaches the immune system. Win-Glio removes its restraints. Liau built the primer. Mulholland triggers the release. This isnt overlap its orchestration. Dame Siobhain McDonagh didnt just raise 1M for Win-Glio. She pushed Parliament to act and SI 2025/87 followed. Now patient-specific therapies can be labeled shipped and administered under Specials law. And the only therapy that qualifies (right now) is DCVax-L. The"
@andrewcaravello on X 2025-07-21 12:03:06 UTC 1086 followers, 2309 engagements

"🔬 The Silence Was the Strategy and the Signal Was in the Cells TL;DR 🪶 This isnt a thread. Its a blueprint. $NWBO didnt stay silent by accident. It built and protected the first scalable platform to train dendritic cells against tumor vasculature and proved it in the largest glioblastoma trial ever run. Mayo Clinic helped validate the mechanism. Ivy quietly backed the science. But NWBO developed it licensed it and owns it. 🕰 Estimated reading time: XXX min Northwest Biotherapeutics has long been defined by what it didnt say. While most biotech companies rushed to publish splashy press"
@andrewcaravello on X 2025-07-10 17:49:52 UTC 1088 followers, 4479 engagements

"🧬 This Is How You Launch an Immune Engine in X Months #DCVax CNPV and the Rise of the Modular Cancer Vaccine $NWBO $MRK $PFE $BMY The FDA didnt just open a new review pathway They created a fast pass for therapies that can change medicine Its called the Commissioners National Priority Voucher (CNPV) and if executed correctly it could deliver full FDA approval for DCVax-L in X months or less DCVax-Direct isnt far behind And the Mayo Clinic already proved the method Heres how it works Step One: The Voucher That Changed the Game No BLA required to apply No need to restart trials Just submit a"
@andrewcaravello on X 2025-07-22 22:04:30 UTC 1084 followers, 3269 engagements

"🧠Strategic Convergence: Yorkville $NWBO Indaptus and Modular Immune Architecture 📡 TL;DR (22-25 min read): Yorkvilles dual financing of NWBO and $INDP reveals a deeper strategy: the rise of a programmable immunotherapy system. #DCVax DECOY20 and Eden form the core of an adaptive platform that integrates danger signals viral ignition and synthetic TLR boosters. Not a drug; a system. Not a company; a platform. In early 2025 Yorkville Advisors (YA II PN Ltd.) executed two sequential financing agreements: X. A $X million convertible note with Northwest Biotherapeutics announced on February 13"
@andrewcaravello on X 2025-07-14 08:56:09 UTC 1088 followers, 8696 engagements

"🧬 How $MRK WP50 Became the Hidden Deployment Hub for $NWBO Programmable Immune System What began as a vaccine plant is now the staging ground for modular patient-specific immunotherapy kits built to deploy not mass-produce. Estimated Read Time: 24-28 minutes 🏗 The Facility That Quietly Changed Everything In early 2021 as global headlines focused on mRNA Merck quietly broke ground on a project that had nothing to do with COVID flu or Gardasil. The filing called it Building XX WP50 in internal terms and labeled it a vaccine and office expansion at the companys massive West Point campus in"
@andrewcaravello on X 2025-07-23 10:52:37 UTC 1088 followers, 6424 engagements

"🧬 $NWBO DCVax: The Platform That Owns the Mechanism 🕰 Est. Read Time: 2832 min 📌 TL;DR The Core in One Read DCVax is not just a vax its a programmable immune system. Built on autologous DCs pooled tumor lysate and plug-in TLR-based boosters it delivers personalized instruction without requiring pt-specific tumor samples. The DC maturation protocol developed by Dr. Kalinski (Roswell) and now exclusively licensed to NWBO has already been validated in real pts across GBM (Mayo) and melanoma (JITC 2021). TBVA logic drives tumor-agnostic targeting with the Bosch Matrix enabling immune"
@andrewcaravello on X 2025-07-17 13:20:12 UTC 1081 followers, 4178 engagements

"❓ Why wouldnt $MRK just buy Mill Creek Life Sciences to better position itself 🧬 X. Mill Creeks Utility Is Tied to $NWBO s IP Not Freestanding Mill Creek manufactures pooled lysate but that lysate only becomes clinically actionable when paired with a dendritic cell maturation protocol like the M7 method which is: Patented by Roswell Park Exclusively licensed by NWBO Core to the Mayo Clinic trials that used Mill Creek lysate 🧠 That means: Merck could own the lysate factory but not the right to use it with DCs the way Mayo did unless they license from NWBO. The lysate has no standalone value"
@andrewcaravello on X 2025-07-22 17:31:13 UTC 1086 followers, XXX engagements

"Ongoing discussion around $NWBO and $IBRX especially after @maveric92283613 post warrants clarity on what Dr. Makary actually said and what he was pointing to: Id like to see more cancer therapies that apply to stage X metastatic disease and cancer therapies that result in what we call in medicine a complete pathologic response. That is the cancer melts away eliminated without chemo surgery or radiation therapy. Makary wasnt speculating. He referenced therapies already in the pipeline. And his language eliminated without chemo surgery or radiation didnt just describe efficacy. It implied"
@andrewcaravello on X 2025-07-15 08:42:57 UTC 1086 followers, 3431 engagements

"🧬 Tumor Neutrophils Immune Reprogramming and the Silent Stack Behind It All $MRK Baker Bros and $NWBO are not competitors they are coding different layers of the same immune operating system. Estimated Read Time: XX minutes 🧬 TL;DR: Merck is targeting immune tone (PDE3/4). Baker is reprogramming neutrophil identity (DPP1). NWBO is the execution stack turning these signals into patient-specific deployable immune circuits. This isnt a pipeline its an operating system. 🧬 Introduction: The Hidden War for Immune Terrain For nearly a decade the frontline of immuno-oncology has been defined by"
@andrewcaravello on X 2025-07-24 21:27:25 UTC 1088 followers, 3820 engagements

"As mentioned in the two previous posts responding to this exact scenario the idea of Merck acquiring Mill Creek has already been addressed from multiple angles and the conclusions havent changed. Even if Merck were to buy Mill Creek it wouldnt alter the fundamental positioning. Mill Creek manufactures pooled lysate but that lysate only becomes therapeutically meaningful when paired with the M7 dendritic cell maturation protocol which is exclusively licensed to NWBO. Without that license Merck couldnt legally or clinically reproduce the Mayo trial structure nor could it generate a comparable"
@andrewcaravello on X 2025-07-22 17:55:40 UTC 1083 followers, XX engagements

"$NWBO s immune framework continues to play out in real time and what makes it even more remarkable is that ipilimumab $BMY the checkpoint used in WinGlio isnt just checkpoint therapy. Its a Matrix Class B booster Bosch had already tested with DCVax long before this trial ever began. WinGlio didnt use DCVax but it confirmed what Bosch had shown preclinically: 🔹 CTLA4 blockade enhances dendritic cell priming 🔹 It acts in the lymph nodes not the tumor 🔹 And it unlocks the front end of the immune cascade DCVax was built to drive So while the trial was DCVaxfree it was not outside the framework"
@andrewcaravello on X 2025-07-21 13:22:27 UTC 1088 followers, 1746 engagements